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https://www.readbyqxmd.com/read/29693378/the-positively-charged-hyperbranched-polymers-with-tunable-fluorescence-and-the-cell-imaging-application
#1
Hengchang Ma, Yanfang Qin, Zenming Yang, Manyi Yang, Yucheng Ma, Pei Yin, Yuan Yang, Tao Wang, Ziqiang Lei, Xiaoqiang Yao
Fluorescence-tunable materials are becoming increasingly attractive for their potential application in optics, electronics, and biomedical technology. Herein, a multi-color molecular pixel system is realized using simple copolymerization method. Bleeding both of complementary colors from blue and yellow fluorescence segments, reproduced a serious multicolor fluorescence materials. Interestingly, the emission colors of the polymers can be fine-tuned in solid state, solution phase, and in hydrogel state. More importantly, the positive fluorescent polymers exhibited cell-membrane permeable ability, and were found to accumulate on the cell nucleus, exhibiting remarkable selectivity to give bright fluorescence...
April 25, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29676865/detecci%C3%A3-n-de-treponema-pallidum-subespecie-pallidum-para-el-diagn%C3%A3-stico-de-s%C3%A3-filis-cong%C3%A3-nita-mediante-reacci%C3%A3-n-en-cadena-de-la-polimerasa-anidada
#2
Gladys Pinilla, Lesly Campos, Andrea Durán, Jeannette Navarrete, Liliana Muñoz
Introducción. La sífilis es una enfermedad producida por Treponema pallidum subespecie pallidum cuya incidencia mundial es de 12 millones de casos por año, aproximadamente; de estos, más de dos millones se presentan en mujeres gestantes, siendo la sífilis congénita la complicación más grave de esta infección en el embarazo.Objetivo. Detectar la presencia de T. pallidum subespecie pallidum en muestras clínicas para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa (PCR) anidada y determinar su concordancia con las pruebas serológicas...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29606102/the-performance-of-rapid-plasma-reagin-rpr-titer-in-hiv-negative-general-paresis-after-neurosyphilis-therapy
#3
Ying Jiang, Ruihui Weng, Yuefeng Zhang, Rong Fan, Yulun Liu, Zhigang Chen, Fuhua Peng, Yong Chen, Xiaohong Chen
BACKGROUND: Repeated nontreponemal serologic test for syphilis titers is recommended to evaluate treatment response. However, it is unknown whether serum rapid plasma reagin (RPR) titer can serve as a surrogate for determining the efficacy of treatment in general paresis (GP) remains unknown. METHODS: We retrospectively reviewed data from 105 GP patients, who were divided into two groups (62 CSF RPR+ patients and 43 CSF RPR- patients) according to reactive RPR test status in CSF...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29533608/bifunctional-porphyrin-based-nano-metal-organic-frameworks-catalytic-and-chemosensing-studies
#4
Carla F Pereira, Flávio Figueira, Ricardo F Mendes, João Rocha, Joseph T Hupp, Omar K Farha, Mário M Q Simões, João P C Tomé, Filipe A Almeida Paz
The use of 5,10,15,20-tetrakis( p-phenylphosphonic acid)porphyrin (H10 TPPA) as a linker in the preparation of porphyrin-based metal-organic frameworks (Por-MOFs) through coordination to lanthanides cations is reported. The resulting unprecedented materials, formulated as [M(H9 TPPA)(H2 O) x ]Cl2 · yH2 O [ x + y = 7; M3+ = La3+ (1), Yb3+ (2), and Y3+ (3)], prepared using hydrothermal synthesis, were extensively characterized in the solid-state, for both their structure and thermal robustness, using a myriad of solid-state advanced techniques...
April 2, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29465737/a-novel-panchromatic-shutter-based-on-an-ambipolar-electrochromic-system-without-supporting-electrolyte
#5
Jung-Tsu Wu, Guey-Sheng Liou
Two triphenylamine derivatives, N,N,N',N'-tetrakis(4-methoxyphenyl)-1,4-phenylenediamine TPPA and N,N,N',N'-tetrakis(4-methoxyphenyl)-1,1'-biphenyl-4,4'-diamine TPB, were successfully prepared and combined with HV to fabricate the electrochromic device as a panchromatic shutter for the application of transparent display. The obtained electrochromic device exhibits exceptional novel electrochromic properties, including enhanced color contrast, switching time, and long-term stability. Furthermore, it is worth mentioning that the most important contribution of this ambipolar system approach is that no supporting electrolyte is added into the device...
March 8, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29444835/retrospective-review-of-treponema-pallidum-pcr-and-serology-results-are-both-tests-necessary
#6
Anna Brischetto, Ian Gassiep, David Whiley, Robert Norton
There has been a resurgence of syphilis diagnoses in Australia. We investigated whether our Treponema pallidum PCR test provides any additional diagnostic information over syphilis serology (chemiluminescence immunoassay [CMIA], Treponema pallidum particle agglutination [TPPA] assay, and the rapid plasma reagin [RPR] flocculation test). A retrospective audit of all T. pallidum PCR requests that came through our laboratory from January 2010 to June 2017 was conducted; data collected included age, gender, site of swab, and results from T...
May 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29223963/field-evaluation-of-two-point-of-care-tests-for-syphilis-among-men-who-have-sex-with-men-verona-italy
#7
Antonella Zorzi, Maddalena Cordioli, Lorenzo Gios, Paola Del Bravo, Igor Toskin, Rosanna W Peeling, Karel Blondeel, Giuseppe Cornaglia, James Kiarie, Ronald Ballard, Massimo Mirandola
OBJECTIVES: The incidence of HIV and syphilis among men who have sex with men (MSM) in Europe has recently increased. Rapid point-of-care tests (POCTs) for syphilis can improve access to screening. The purpose of this study was to evaluate the performance of two syphilis POCTs compared with laboratory tests among MSM. METHODS: The study was undertaken in Verona, Italy. Asymptomatic MSM, potentially exposed to syphilis, were enrolled prospectively. The POCTs evaluated were SD Bioline Syphilis 3...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29201173/serological-evaluation-of-antigen-tp0693-for-diagnosis-of-syphilis
#8
Li Zhang, Meixia Deng, Xiaohong Zhang, Weiguo Yin, Wen Liu, Xi Luo, Jie Yang, Fei Chen, Feijun Zhao
The aim of the present study was to evaluate the diagnostic value of the Treponema pallidum (Tp) antigen Tp0693 for syphilis. ELISA was used to examine the serum levels of Tp0693. The sample-to-cutoff ratio (S/CO) value was used to generate a receiver operating characteristic (ROC) curve. A correlation analysis was performed to compare the detection efficacy of Tp0693-specific ELISA, Treponema pallidum Particle Agglutination (TPPA), Tolulized Red Unheated Serum test (TRUST) and LiZhu™ Tp-ELISA. The area under the ROC curve was 0...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29117430/biological-false-positive-venereal-disease-research-laboratory-test-in-cerebrospinal-fluid-in-the-diagnosis-of-neurosyphilis-a-case-control-study
#9
S Zheng, R J Lin, Y H Chan, C C L Ngan
BACKGROUND: There is no clear consensus on the diagnosis of neurosyphilis. The Venereal Disease Research Laboratory (VDRL) test from cerebrospinal fluid (CSF) has traditionally been considered the gold standard for diagnosing neurosyphilis but is widely known to be insensitive. OBJECTIVE: In this study, we compared the clinical and laboratory characteristics of true-positive VDRL-CSF cases with biological false-positive VDRL-CSF cases. METHODS: We retrospectively identified cases of true and false-positive VDRL-CSF across a 3-year period received by the Immunology and Serology Laboratory, Singapore General Hospital...
March 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29050149/-accuracy-analysis-and-comparison-of-different-serological-detection-methods-in-syphilis
#10
M Hu, N Liu, Y Y Cai, T Lei, M Zhang
Objective: To compare the accuracy of different methods by reviewing syphilis serologic screening external quality assessment (EQA) data of Chinese primary health care institutions. Methods: The EQA was based on one or two distinct shipments from 2011 to 2016. Each shipment consisted of five serum samples. The laboratories performed the EQA and sent back the results by the deadline. The results were analyzed using the standard procedures and methods. Results: Six different methods were used for syphilis serologic screening: enzyme linked immunosorbent assay, colloidal gold method, Treponema pallidum particle agglutination (TPPA) test, rapid plasma reagin card test, toluidine red unheated serum reagin test and chemiluminescence immunoassay...
September 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28855625/serological-response-predicts-normalization-of-cerebrospinal-fluid-abnormalities-at-six-months-after-treatment-in-hiv-negative-neurosyphilis-patients
#11
Yao Xiao, Man-Li Tong, Li-Rong Lin, Li-Li Liu, Kun Gao, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Tian-Ci Yang, Jian-Jun Niu
This study aimed to determine whether a serological response could predict the normalization of cerebrospinal fluid (CSF) abnormalities at 6 months after treatment in human immunodeficiency virus (HIV)-negative neurosyphilis patients. A total of 123 neurosyphilis patients were recruited at baseline, 58 of these patients undergoing treatment, repeated CSF examinations and serological tests for syphilis at 6 months after treatment were included in the follow-up study. Before treatment, the CSF rapid plasma reagin (RPR) titer, CSF Treponema pallidum particle agglutination (TPPA) titer, CSF leukocyte count, and CSF protein concentration were correlated with both serum RPR and TPPA titers...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28768925/reduction-sensitive-poly-ethylenimine-nanogel-bearing-dithiodipropionic-acid
#12
Huangying Guo, Jin-Chul Kim
Reduction-sensitive nanogel was developed by including dithiodipropionic acid (DTPA) in tripolyphosphoric acid (TPPA) cross-linked poly(ethylenimine) (PEI) nanogel. According to the light scattering measurement, DTPA (a disulfide compound) seemed to cross-link PEI chains in a cooperative manner with TPPA (a multi-valent anion). Nanogels composed of TPPA, PEI, and DTPA exhibited negative zeta potential and the absolute value increased with the amount of TPPA and DTPA. TPPA and DTPA were found to be contained in the nanogel, evidenced by Fourier transform (FT)-IR spectroscopy and Raman spectroscopy, respectively...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28765847/highly-efficient-enrichment-of-n-linked-glycopeptides-using-a-hydrophilic-covalent-organic-framework
#13
Yu-Fang Ma, Fang Yuan, Xiao-Hui Zhang, Ying-Lin Zhou, Xin-Xiang Zhang
The enrichment of glycopeptides plays an important role in glycoproteomics. In this paper, a covalent-organic framework called TpPa-1, synthesized by the Schiff base reaction of 1,3,5-triformylphloroglucinol and paraphenylenediamine, was first successfully utilized as a hydrophilic porous material for N-linked glycopeptide enrichment. Using this material, interference from non-glycopeptides could be efficiently eliminated, which facilitated the mass spectrometry detection of glycopeptides. By capturing N-linked glycopeptides from tryptic digests of human IgG, our method was proved to have high sensitivity at the femtomole level...
August 2, 2017: Analyst
https://www.readbyqxmd.com/read/28727773/the-tradition-algorithm-approach-underestimates-the-prevalence-of-serodiagnosis-of-syphilis-in-hiv-infected-individuals
#14
COMPARATIVE STUDY
Bin Chen, Xiuming Peng, Tiansheng Xie, Changzhong Jin, Fumin Liu, Nanping Wu
Currently, there are three algorithms for screening of syphilis: traditional algorithm, reverse algorithm and European Centre for Disease Prevention and Control (ECDC) algorithm. To date, there is not a generally recognized diagnostic algorithm. When syphilis meets HIV, the situation is even more complex. To evaluate their screening performance and impact on the seroprevalence of syphilis in HIV-infected individuals, we conducted a cross-sectional study included 865 serum samples from HIV-infected patients in a tertiary hospital...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28661234/an-evaluation-of-the-sd-bioline-hiv-syphilis-duo-test
#15
Jeffrey Holden, Joshua Goheen, Mary Jett-Goheen, Mathilda Barnes, Yu-Hsiang Hsieh, Charlotte A Gaydos
Many health agencies now recommend routine HIV and syphilis testing for pregnant women and most-at-risk populations such as men who have sex with men. With the increased availability of highly sensitive, low cost rapid point-of-care tests, the ability to meet those recommendations has increased, granting wider access to quick and accurate diagnoses. Using blood specimens collected from a Baltimore City Health Department (BCHD) sexually transmitted infection clinic, we evaluated the SD Bioline HIV/Syphilis Duo, a rapid test that simultaneously detects antibodies to HIV and syphilis and has the potential to further benefit clinics and patients by reducing costs, testing complexity, and patient wait times...
January 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28660379/hiv-incidence-and-care-linkage-among-msm-first-time-testers-in-shenyang-china-2012-2014
#16
Jing Zhang, Jun-Jie Xu, Wei Song, Shi Pan, Zhen-Xing Chu, Qing-Hai Hu, Huan Yu, Xiang Mao, Yong-Jun Jiang, Wen-Qing Geng, Hong Shang, Ning Wang
HIV testing is the first step to the fulfillment of Treat as Prevention (TasP) and reaching the 90-90-90 goal in HIV control. However, there are still a large number of Men who have Sex with Men (MSM) have never been tested for HIV before, and little is known about the HIV incidence and care linkage among this population. A Mixed method was used to recruit MSM who had never tested for HIV before from January 2012 to December 2014 in Shenyang, China. Potential MSM participants were invited to attend the enrollment for HIV and syphilis testing at a general hospital-based voluntary counseling and test (VCT)...
March 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/28614239/the-analyzation-and-clinical-evaluation-of-eclia-and-cmia-in-the-detection-of-treponema-pallidum
#17
COMPARATIVE STUDY
Jiansuo Zhou, Yongming Liang, Jie Zhang, Liyan Cui
To evaluate the clinical application value of electrochemiluminescence immunoassay analyzer (ECLIA) and chemiluminescent magnetic microparticle immunoassay (CMIA) in the detection of Treponema pallidum (TP).A total of 1225 patients in Peking University Third Hospital was enrolled from June 2014 to October 2014. ECLIA and CMIA were applied to detect the serum anti-TP. The positive rate was analyzed. RIBA was taken as a golden standard to evaluate the sensitivity, the specificity, the positive predictive value, the negative predictive value, and the accuracy of ECLIA and CMIA...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28446129/novel-predictors-of-neurosyphilis-among-hiv-negative-syphilis-patients-with-neurological-symptoms-an-observational-study
#18
Yao Xiao, Man-Li Tong, Li-Li Liu, Li-Rong Lin, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Hui-Qin Xing, Jian-Jun Niu, Tian-Ci Yang
BACKGROUND: Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteristics, particularly those with neurological symptoms. This study aimed to identify novel predictors of HIV-negative symptomatic neurosyphilis (S-NS). METHODS: From June 2005 to June 2015, 370 HIV-negative syphilis patients with neurological symptoms were recruited, consisting of 191 S-NS patients (including 123 confirmed neurosyphilis and 68 probable neurosyphilis patients) and 179 syphilis/non-neurosyphilis (N-NS) patients...
April 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28400821/the-great-impostor-transaminitis-masking-the-coinfection-of-syphilis-and-human-immunodeficiency-virus
#19
Sunit Tolia, Hassan Kassem, Ana Capatina-Rata
Introduction. The incidence of syphilis continues to rise in the United States over the past 15 years. This disease process is classified into stages and may present with a coinfection of Human Immunodeficiency Virus (HIV). Case Report. We present a case of a 32-year-old African American male who presented with cutaneous manifestations of secondary syphilis and transaminitis. A workup revealed that the transaminitis was secondary to underlying syphilitic hepatitis in the presence of HIV coinfection. The patient had a reactive rapid plasma reagin (RPR) of 1 : 64 TU and reactive Treponema pallidum particle agglutination assay (TPPA)...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28381602/cerebrospinal-fluid-treponema-pallidum-particle-agglutination-assay-for-neurosyphilis-diagnosis
#20
Christina M Marra, Clare L Maxwell, Shelia B Dunaway, Sharon K Sahi, Lauren C Tantalo
Limited data suggest that the cerebrospinal fluid Treponema pallidum particle agglutination assay (CSF-TPPA) is sensitive and a CSF Treponema pallidum hemagglutination assay (CSF-TPHA) titer of ≥1:640 is specific for neurosyphilis diagnosis. CSF-TPPA reactivity and titer were determined for a convenience sample of 191 CSF samples from individuals enrolled in a study of CSF abnormalities in syphilis (training data set). The sensitivity of a reactive test and the specificity for reactivity at serial higher CSF dilutions were determined...
June 2017: Journal of Clinical Microbiology
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