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Hayoung Park, Kelika A Konda, Chelsea P Roberts, Jorge L Maguiña, Segundo R Leon, Jesse L Clark, Thomas J Coates, Carlos F Caceres, Jeffrey D Klausner
BACKGROUND: Syphilis is concentrated among high-risk groups, but the epidemiology of syphilis reinfection is poorly understood. We characterized factors associated with syphilis incidence, including reinfection, in a high-risk cohort in Peru. METHODS: Participants in the NIMH CPOL trial were assessed at baseline and 2 annual visits with HIV/STI testing and behavioral surveys. Participants diagnosed with syphilis also attended 4- and 9-month visits. All participants underwent syphilis testing with RPR screening and TPPA confirmation...
2016: PloS One
Michael Marks, Oliver Sokana, Eli Nachamkin, Elliot Puiahi, Georgina Kilua, Allan Pillay, Christian Bottomley, Anthony W Solomon, David C Mabey
INTRODUCTION: Both yaws and trachoma are endemic in the Pacific. Mass treatment with azithromycin is the mainstay of the WHO strategy for both the eradication of yaws and the elimination of trachoma as a public health problem, but the dose recommended for trachoma is lower than that for yaws. In countries where both diseases are endemic, there is a potential for synergy between yaws and trachoma control programs if mass treatment with the lower dose of azithromycin was shown to be effective for the treatment of yaws...
August 2016: PLoS Neglected Tropical Diseases
F Xia, Y H Xu, X L Wang
OBJECTIVE: To explore the clinical value of five methods commonly used for the detection of clinical syphilis antibody. METHODS: A total of 160 confirmed syphilis cases were chosen as the experimental group while 200 non-syphilis cases were set as the control group. Serum specimens were detected by methods as Treponema pallidum particle agglutination assay (TPPA), chemiluminescent microparticle immune assay (CMIA), enzyme linked immunosorbent assay (ELISA), emulsion method (TP-AD) and toluidine red unheated serum test (TRUST)...
June 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Ronald Labonté, Ashley Schram, Arne Ruckert
BACKGROUND: In early October 2015, 12 nations signed the Trans-Pacific Partnership Agreement (TPPA), promoted as a model '21(st) century' trade and investment agreement that other countries would eventually join. There are growing concerns amongst the public health community about the potential health implications of such WTO+ trade and investment agreements, but little existing knowledge on their potential health impacts. METHODS AND RESULTS: We conducted a health impact review which allows for a summary estimation of the most significant health impacts of a set of policies, in our case the TPPA...
2016: Globalization and Health
Amphiwan Boonchaoy, Piya Wongchampa, Nattiya Hirankarn, Surasith Chaithongwongwatthana
OBJECTIVE: This study evaluated the diagnostic performance of chemiluminescent microparticle immunoassay (CMIA) in screening for syphilis in Asian pregnant women. MATERIAL AND METHOD: This study retrospectively reviewed the CMA results of pregnant women attending the antenatal care clinic, King Chulalongkorn Memorial Hospital. Women with reactive CMA results were extracted from the laboratory database and further analyzed. A reactive/positive result for Treponema pallidum was defined as having a sample/cut-off absorbance ratio of ≥ 1...
February 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Susan Hornsby-Geluk
No abstract text is available yet for this article.
March 2016: Nursing New Zealand, Kai Tiaki
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Nursing New Zealand, Kai Tiaki
Vivian Black, Brian G Williams, Venessa Maseko, Frans Radebe, Helen V Rees, David A Lewis
BACKGROUND: Point-of-care tests provide immediate results with the opportunity for same-day interventions with improved public health outcomes. A dual HIV/syphilis test enables early treatment of both diseases. METHODS: We conducted a field evaluation of the Standard Diagnostics' SD Bioline HIV/Syphilis Duo test (SD Bioline) among female sex workers. SD Bioline was conducted on finger-prick blood according to manufacturer's instructions and compared with (i) Genscreen HIV1/2 (third generation) and Vironostika Ag/Ab (fourth generation) assays for HIV, and (ii) Treponema pallidum particle agglutination (TPPA) and rapid plasma reagin (RPR) assays for syphilis...
May 6, 2016: Sexually Transmitted Infections
Elisabeth Grube, Cathrine H Olesen, Dorthe B Ravnsbæk, Torben R Jensen
Here we report the synthesis, mechanism of formation, characterization and thermal decomposition of new barium borohydride chlorides prepared by mechanochemistry and thermal treatment of MBH4-BaCl2, M = Li, Na or K in ratios 1 : 1 and 1 : 2. Initially, orthorhombic barium chloride, o-BaCl2 transforms into o-Ba(BH4)xCl2-x, x ∼ 0.15. Excess LiBH4 leads to continued anion substitution and a phase transformation into hexagonal barium borohydride chloride h-Ba(BH4)xCl2-x, which accommodates higher amounts of borohydride, possibly x ∼ 0...
May 10, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
(no author information available yet)
No abstract text is available yet for this article.
February 2016: Nursing New Zealand, Kai Tiaki
Gretchen M Cooley, Oriol Mitja, Brook Goodhew, Allan Pillay, Patrick J Lammie, Arnold Castro, Penias Moses, Cheng Chen, Tun Ye, Ronald Ballard, Diana L Martin
WHO has targeted yaws for global eradication by 2020. The program goals are to interrupt the transmission in countries where yaws is endemic and to certify countries as yaws free where yaws was endemic in the past. No new rapid plasmin reagin (RPR) seroreactivity in young children is required for certification of elimination at a country level. We sought to evaluate whether antibody responses to specific treponemal antigens measured in a high-throughput multiplex bead array (MBA) assay differentiate past versus current infection and whether a nontreponemal lipoidal antigen test can be incorporated into the MBA...
May 2016: Journal of Clinical Microbiology
Gay Keating, Joshua Freeman, Alex Macmillan, Pat Neuwelt, Eric Monasterio
No abstract text is available yet for this article.
February 19, 2016: New Zealand Medical Journal
Bishnu P Biswal, Harshal D Chaudhari, Rahul Banerjee, Ulhas K Kharul
Highly flexible, TpPa-1@PBI-BuI and TpBD@PBI-BuI hybrid membranes based on chemically stable covalent organic frameworks (COFs) could be obtained with the polymer. The loading obtained was substantially higher (50 %) than generally observed with MOFs. These hybrid membranes show an exciting enhancement in permeability (about sevenfold) with appreciable separation factors for CO2/N2 and CO2/CH4. Further, we found that with COF pore modulation, the gas permeability can be systematically enhanced.
March 24, 2016: Chemistry: a European Journal
Sunil Sethi, Abhishek Mewara, Vinaykumar Hallur, Amber Prasad, Kusum Sharma, Atul Raj
BACKGROUND AND OBJECTIVES: Syphilis is a classical sexually transmitted disease (STD), caused by Treponema pallidum subsp. pallidum. In this retrospective study, we analyzed trends of syphilis prevalence in patient groups attending our tertiary care center. MATERIALS AND METHODS: The data was obtained by reviewing laboratory records of the STD laboratory from January 1, 2006 to December 31, 2011. Cases positive by both Venereal Disease Research Laboratory (VDRL) and Treponema pallidum particle agglutination (TPPA) tests were analyzed for seroprevalence of syphilis in different groups, and to analyze the rising or falling trends, if any...
July 2015: Indian Journal of Sexually Transmitted Diseases
Zhiyan Li, Zhenru Feng, Ping Liu, Cunling Yan
BACKGROUND: Traditionally, testing for syphilis has consisted of initial screening with a non-treponemal test, then retesting reactive specimens with a treponemal test. Recent availability of a chemiluminescent microparticle immunoassay for detecting antibodies against Treponema pallidum has led several laboratories in China to adopt chemiluminescent microparticle immunoassay for screening of syphilis, with subsequent testing of reactive serum samples with non-treponemal tests. We evaluated the utility of chemiluminescent microparticle immunoassay for routine screening of syphilis...
September 2016: Annals of Clinical Biochemistry
(no author information available yet)
No abstract text is available yet for this article.
October 2015: Nursing New Zealand, Kai Tiaki
Hee Jin Huh, Jae Woo Chung, Seong Yeon Park, Seok Lae Chae
BACKGROUND: Automated Mediace Treponema pallidum latex agglutination (TPLA) and Mediace rapid plasma reagin (RPR) assays are used by many laboratories for syphilis diagnosis. This study compared the results of the traditional syphilis screening algorithm and a reverse algorithm using automated Mediace RPR or Mediace TPLA as first-line screening assays in subjects undergoing a health checkup. METHODS: Samples from 24,681 persons were included in this study. We routinely performed Mediace RPR and Mediace TPLA simultaneously...
January 2016: Annals of Laboratory Medicine
X Song, L Tian, H Zou, H Sun
OBJECTIVE: To analyze the clinical testing data of syphilis suspected children, to give more comprehensive detection information and offer experimental basis for the clinical diagnosis of syphilis. METHODS: From April 2010 to December 2012, 141 suspected syphilis children, 0-3 years old in XuZhou Children's Hospital were selected and divided into two groups: infants group (0-<1 years old, 119 cases) and children group (1-3 years old, 22 cases). Blood samples were collected from these children and following experimental detection methods were used: the rapid plasma reagin (RPR) test, the colloidal gold test (SYP), the enzyme-linked immuno-sorbent assay (ELISA) and the Treponema pallidum particle agglutination (TPPA) test...
September 11, 2015: Minerva Pediatrica
Na-Li Huang, Lei Ye, Marion E Schneider, Yi-Xin Du, Yuan-Hong Xu, Li-Bin Fan, Wei-Dong Du
In this study, we developed a novel protein biochip methodology that was characterized by dithiobis (succinimidyl undecanoate) (DSU) and specialized for detection of serum IgG and IgM antibodies against Treponema pallidum pathogens in the patients with syphilis, respectively. The biochips were validated by a dimension of atomic force microscope (AFM). The visualized detection limit of IgG antibody on the biochip was 0.39μg/ml. Finally, 286 serum samples from the patients with syphilis were simultaneously tested on the rTpN15-17-47 coated biochips...
January 15, 2016: Biosensors & Bioelectronics
Ke-Di Wang, Dong-Jiang Xu, Jian-Rong Su
BACKGROUND: With the rapid expansion of infectious syphilis all over the world, optimal procedures for screening syphilis are urgently required. Conventional methods for the diagnosis of syphilis are time- and labor-consuming. We compared automated chemiluminescent micro-particle immunoassay (CLIA) with conventional methods to verify whether CLIA is feasible for syphilis screening. METHODS: A cross-sectional assay was conducted on 3962 serum samples tested by CLIA, rapid plasma reagin test (RPR), and Treponema pallidum particle agglutination (TPPA)...
2016: Infectious Diseases
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