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https://www.readbyqxmd.com/read/28738852/tertiary-syphilis-in-the-lumbar-spine-a-case-report
#1
Yang Bai, Feng Niu, Lidi Liu, Hui Sha, Yimei Wang, Song Zhao
BACKGROUND: The incidence of tertiary syphilis involvement in the spinal column with destructive bone lesions is very rare. It is difficult to establish the correct diagnosis from radiographs and histological examination alone. Limited data are available on surgical treatment to tertiary syphilitic spinal lesions. In this article, we report a case of tertiary syphilis in the lumbar spine with osteolytic lesions causing cauda equina compression. CASE PRESENTATION: A 44-year-old man who suffered with low back pain for 6 months and progressive radiating pain at lower extremity for 1 week...
July 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28606185/non-malarial-infectious-diseases-of-antenatal-care-in-pregnant-women-in-franceville-gabon
#2
Irene Pegha Moukandja, Edgard Brice Ngoungou, Guy Joseph Lemamy, Ulrick Bisvigou, Antoine Gessain, Fousseyni S Toure Ndouo, Mirdad Kazanji, Jean Bernard Lekana-Douki
BACKGROUND: In sub-tropical countries, infectious diseases remain one of the main causes of mortality. Because of their lack of active immunity, pregnant women and their unborn children represent the most susceptible people. In Gabon, data on infectious diseases of pregnant women such as syphilis and rubella are either scarce or very old. Few studies have assessed T. gondii infection during pregnancy in the country. Here, we evaluate seroprevalence of HIV, HTVL-1, syphilis and T. gondii and rubella infection during antenatal care among women living in Franceville, Gabon...
June 12, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28559923/prevalence-and-risk-factors-associated-with-sexually-transmitted-infections-stis-among-women-of-reproductive-age-in-swaziland
#3
Themba G Ginindza, Cristina D Stefan, Joyce M Tsoka-Gwegweni, Xolisile Dlamini, Pauline E Jolly, Elisabete Weiderpass, Nathalie Broutet, Benn Sartorius
BACKGROUND: Sexually transmitted infections (STIs) remain an important public health problem with approximately half a billion new cases annually among persons aged 15-49 years. Epidemiological data on STIs among women of reproductive age in Swaziland are limited. The availability of epidemiological data on STIs and associated risk factors in this population is essential for the development of successful prevention, diagnosis and management strategies in the country. The study aimed to determine the prevalence and risk factors associated with STIs...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28557682/an-infant-presenting-with-failure-to-thrive-and-hyperkalaemia-owing-to-transient-pseudohypoaldosteronism-case-report
#4
Marieke De Clerck, Johan Vande Walle, Evelyn Dhont, Joke Dehoorne, Werner Keenswijk
A 3-month-old boy presented with failure to thrive and a history of a prenatally detected unilateral hydroureteronephrosis which was confirmed after birth. His growth and developmental milestones had been normal during the first 2 months but in the third month his appetite was poor with reduced intake but no vomiting. At presentation, his temperature was normal, there was mild dehydration and there was weight loss (his weight had decreased by 270 g in the past month). Haemoglobin was 11.9 g/dL, total white cell count 20...
May 30, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28507905/gastric-syphilis
#5
Jianfei Cai, Danian Ji, Jian-Long Guan
Syphilis is a chronic systemic infectious disease. Gastric involvement is uncommon. We report of a 55-year-old female patient with a history of epigastric pain and a diagnosis of Syphilis confirmed by main clinical symptoms, tolulized red unheated serum test(TRUST) and treponema pallidum hemagglutination assay(TPHA). At the same time, we still reported gastric involvement about syphilis in this patient with gastroscopy and pathology.
2017: IDCases
https://www.readbyqxmd.com/read/28484511/reducing-risks-of-transfusion-transmitted-infections-in-a-resource-limited-hospital-based-blood-bank-the-case-of-the-yaound%C3%A3-university-teaching-hospital-cameroon
#6
C T Tagny, A Ndoumba, S Laperche, E Murphy, D Mbanya
BACKGROUND AND OBJECTIVES: Although interest in assessing risk of TTIs, very few trends in blood safety epidemiological data from resource-limited blood services are reported in the literature. This analysis aims at reporting trends in seroprevalences of TTIs in blood donations in the Yaoundé University Teaching Hospital (UTH) from 2011 to 2015 and to describe reasons for these changes. MATERIALS AND METHODS: All donations of 2015 were tested for HIV 1&2 antibodies and the P24 antigen, HBsAg, HCV antibody and the Treponema pallidum antibody...
August 2016: ISBT Science Series
https://www.readbyqxmd.com/read/28381602/cerebrospinal-fluid-treponema-pallidum-particle-agglutination-assay-for-neurosyphilis-diagnosis
#7
Christina M Marra, Clare L Maxwell, Shelia B Dunaway, Sharon K Sahi, Lauren C Tantalo
Limited data suggest that the cerebrospinal fluid Treponema pallidum particle agglutination assay (CSF-TPPA) is sensitive and a CSF Treponema pallidum hemagglutination assay (CSF-TPHA) titer of ≥1:640 is specific for neurosyphilis diagnosis. CSF-TPPA reactivity and titer were determined for a convenience sample of 191 CSF samples from individuals enrolled in a study of CSF abnormalities in syphilis (training data set). The sensitivity of a reactive test and the specificity for reactivity at serial higher CSF dilutions were determined...
June 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28220718/the-big-imitator-strikes-again-a-case-report-of-neurosyphilis-in-a-patient-with-newly-diagnosed-hiv
#8
Sévérine de Bruijn, Chris Kenyon, Nicolas Léonard, Erika Vlieghe
BACKGROUND: Neurosyphilis is the result of an infection of the central nervous system caused by the spirochete Treponema pallidum. Its clinical presentation includes meningovascular syphilis, tabes dorsalis, and dementia paralytica, resulting in a wide range of symptoms such as psychosis, Parkinsonism, and depression. CASE REPORT: A 49-year-old male was admitted to a psychiatric hospital because of social withdrawal and self-neglect, indicative of a major depression...
February 21, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27992604/incidence-and-risk-factors-for-incident-syphilis-among-hiv-1-infected-men-who-have-sex-with-men-in-a-large-urban-hiv-clinic-in-tokyo-2008-2015
#9
Takeshi Nishijima, Katsuji Teruya, Satoshi Shibata, Yasuaki Yanagawa, Taiichiro Kobayashi, Daisuke Mizushima, Takahiro Aoki, Ei Kinai, Hirohisa Yazaki, Kunihisa Tsukada, Ikumi Genka, Yoshimi Kikuchi, Shinichi Oka, Hiroyuki Gatanaga
BACKGROUND: The epidemiology of incident syphilis infection among HIV-1-infected men who have sex with men (MSM) largely remains unknown. METHODS: The incidence and risk factors for incident syphilis (positive TPHA and RPR> = 1:8) among HIV-1-infected MSM who visited a large HIV clinic in Tokyo for the first time between 2008 and 2013 were determined, using clinical data and stored blood samples taken every three months for screening and determination of the date of incident syphilis...
2016: PloS One
https://www.readbyqxmd.com/read/27833516/utility-of-laboratory-diagnosis-for-confirmation-of-the-syndromic-case-management-in-married-indian-women-with-vaginal-discharge
#10
Prabhav Aggarwal, Sonali Bhattar, Satyendra Kumar Sahani, Preena Bhalla
OBJECTIVE: WHO and NACO recommend treatment of STIs/RTIs on the basis syndromic case management (SCM), even without laboratory confirmation, which may lead to over-treatment. Thus, this study was conducted to evaluate the utility of laboratory diagnosis for confirmation of patients with vaginal discharge diagnosed on the basis of SCM. METHODOLOGY: 234 married women in reproductive age group, diagnosed as having vaginal discharge syndrome were included. Normal saline wet-mount slide preparations were made for detection of motile trichomonads...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27646571/-skin-and-mucosal-erosions-revealing-secondary-syphilis-with-otologic-and-eye-disorders
#11
D Guedes de Carvalho, J Bouleau, M Pichenot, S Dive, L Duthoit, E Auxenfants, O Carpentier
BACKGROUND: The clinical polymorphism of syphilis leads to diagnostic issues. We report a case of secondary syphilis revealed by skin and mucosal erosions, and responsible for sensorineural hearing loss and asymptomatic papillitis. PATIENTS AND METHODS: A 55-year-old man presented oral and peri-anal erosions as the initial symptoms of secondary syphilis. He reported hypoacusis and a pure-tone audiogram revealed bilateral sensorineural hearing loss. Ophthalmological investigation revealed isolated right papillitis and superior temporal scotoma with blind-spot enlargement...
November 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27631356/clinical-evaluation-of-2-point-of-care-lateral-flow-tests-for-the-diagnosis-of-syphilis
#12
Edith Nakku-Joloba, Agnes Kiragga, Joshua Kimeze Mbazira, Fred Kambugu, Mary Jett-Goheen, Rosalind Parkes Ratanshi, Charlotte Gaydos, Yukari C Manabe
A diagnostic performance study comparing the only Food and Drug Administration-approved, point-of-care (POC) treponemal test (Syphilis Health Check) and the World Health Organization pre-qualified SD Bioline POC treponemal test against a treponemal hemagglutination test (TPHA) and a sequential algorithm of nontreponemal rapid plasma reagin and TPHA found both POC tests had >85% sensitivity compared with the TPHA and >85% sensitivity and >95% specificity compared with the rapid plasma reagin and TPHA standards...
October 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27567281/-the-role-of-reflectance-confocal-microscopy-in-the-diagnosis-of-secondary-syphilis-of-the-vulva-and-anus-a-first-case-report
#13
A Leclercq, E Cinotti, B Labeille, B Cribier, A C Biron, C Vermersch, J Montlouis, F Cambazard, J L Perrot
PATIENTS AND METHODS: Herein we report the case of an 18-year-old pregnant patient presenting with plantar and ano-genital lesions of syphilis, pharyngitis, erythematosus and scalynasolabial intertrigo and angular cheilitis. REFLECTANCE CONFOCAL MICROSCOPY: In vivo reflectance confocal microscopy examination (Vivascope 3000(®); Caliber Inc, Rochester, NY, USA, distributed in France by Mavig, Munich) of ano-genital lesions enabled us to identify hyper-reflective elongated rods in the papillary dermis suggesting spirochetes...
November 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27412978/seroepidemiology-of-hiv-syphilis-and-hepatitis-b-and-c-viruses-among-blood-donors-in-bangui-central-african-republic
#14
W S Nambei, D Rawago-Mandjiza, E Gbangbangai
The aim of this study was to determine the seroprevalence of HIV, the hepatitis B and C viruses, and syphilis as well the risk factors for these diseases among blood donors in Bangui, Central Africa Republic. This cross-sectional study examined samples from donors giving blood in August and September, 2013. HIV1/2 antibodies was screened with the Determine and Unigold HIV tests. Hepatitis B surface antigens were detected by sandwich immunochromatographic methods (DIAspot HBsAg test), and antibodies to HCV by the DIAspot test strip...
May 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/27400713/clinical-and-neuropsychological-characteristics-of-general-paresis-misdiagnosed-as-primary-psychiatric-disease
#15
Wang Yanhua, Shi Haishan, Hou Le, Zhong Xiaomei, Chen Xinru, Li Ling, Wu Zhangying, Zheng Dong, Zhang Yuefen, Tan Yan, Luo Xinni, Liu Sha, Ning Yuping
BACKGROUND: Neurosyphilis is caused by the invasion of Treponema pallidum into the central nervous system. General paresis (GP) is a type of neurosyphilis. The main manifestation of general paresis is dementia; however, this is different from the other types of dementia, which can be cured by adequate doses of penicillin in the early stage. Neurosyphilis is the "great imitator" because it can mimic many types of medical disorders. In addition, the manifestations of neurosyphilis are not typical...
July 11, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27030921/comparison-of-performance-of-two-treponema-pallidum-automated-chemiluminescent-immunoassays-in-blood-donors
#16
COMPARATIVE STUDY
Linda Sommese, Chiara Sabia, Antonella Esposito, Carmela Iannone, Maria Lourdes Montesano, Claudio Napoli
The recrudescence of syphilis is leading to the development of new serological tests. The goal of this study was to compare the performance of the more recent Elecsys Syphilis assay, the Electro Chemiluminescence Immunoassay (ECLIA), with the former Architect Syphilis TP assay, the Chemiluminescent Microparticle Immunoassay (CMIA), for the detection of antibodies against Treponema pallidum in blood donors. Serum samples of 5543 voluntary blood donors were screened in parallel with two tests. All repeatedly reactive (RR) samples by one or both assays were further analysed for confirmation by immmunoblot INNO-LIA and TPHA...
2016: Infectious Diseases
https://www.readbyqxmd.com/read/27013811/evaluation-of-sd-bioline-syphilis-3-0-for-rapid-diagnosis-of-syphilis-report-from-a-regional-sexually-transmitted-infection-reference-laboratory-in-north-india
#17
Bhanu Mehra, Sonali Bhattar, Shikhar Saxena, Deepti Rawat, Preena Bhalla
BACKGROUND: Serology is considered the mainstay of syphilis diagnosis. The limitations of the traditional serological methods and the advent and availability of novel immunochromatographic assays have led to the widespread application of rapid point-of-care procedures as screening tools for syphilis. However, these tests have not been extensively evaluated. This study was designed to evaluate the performance of a rapid syphilis diagnostic test known as SD BIOLINE Syphilis 3.0 (SD Biostandard Diagnostics Private Limited, Gurgaon, Haryana, India)...
January 2016: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/26982990/cerebrospinal-fluid-examination-may-be-useful-in-diagnosing-neurosyphilis-in-asymptomatic-hiv-patients-with-syphilis
#18
Ronald Salamano, Raquel Ballesté, Abayubá Perna, Natalia Rodriguez, Diego Lombardo, Natalia García, Pablo López, Pablo Cappuccio
Lumbar puncture in neurologically asymptomatic HIV+ patients is still under debate. There are different criteria for detecting neurosyphilis through cerebrospinal fluid (CSF), especially in cases that are negative through the Venereal Disease Research Laboratory (VDRL), regarding cellularity and protein content. However, a diagnosis of neurosyphilis can still exist despite negative VDRL. Treponema pallidum hemagglutination assay (TPHA) titers and application of the TPHA index in albumin and IgG improve the sensitivity, with a high degree of specificity...
February 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/26962086/evaluation-of-multiplex-based-antibody-testing-for-use-in-large-scale-surveillance-for-yaws-a-comparative-study
#19
COMPARATIVE STUDY
Gretchen M Cooley, Oriol Mitja, Brook Goodhew, Allan Pillay, Patrick J Lammie, Arnold Castro, Penias Moses, Cheng Chen, Tun Ye, Ronald Ballard, Diana L Martin
WHO has targeted yaws for global eradication by 2020. The program goals are to interrupt the transmission in countries where yaws is endemic and to certify countries as yaws free where yaws was endemic in the past. No new rapid plasmin reagin (RPR) seroreactivity in young children is required for certification of elimination at a country level. We sought to evaluate whether antibody responses to specific treponemal antigens measured in a high-throughput multiplex bead array (MBA) assay differentiate past versus current infection and whether a nontreponemal lipoidal antigen test can be incorporated into the MBA...
May 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26866391/oxidation-of-tetraphenylhexaazaanthracene-accessing-a-scissor-dimer-of-a-16%C3%AF-biscyanine
#20
Georgia A Zissimou, Christos P Constantinides, Maria Manoli, Galatia K Pieridou, Sophia C Hayes, Panayiotis A Koutentis
Tetraphenylhexaazaanthracene (TPHA), a fluorescent zwitterionic biscyanine with a closed-shell singlet ground state, on treatment with manganese dioxide or phenyliodine bis(trifluoroacetate) (PIFA), undergoes oxidative dimerization to give a near-zero dipole scissor 5,5'-dimer DI-TPHA. Both acene components of the new dimer DI-TPHA maintain their biscyanine closed-shell singlet ground state motifs, as judged by analysis of both single crystal X-ray crystallographic and density functional theory computational studies; however, unlike TPHA, DI-TPHA is only very weakly fluorescent...
March 4, 2016: Organic Letters
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