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https://www.readbyqxmd.com/read/27898575/rate-of-decline-in-nontreponemal-antibody-titers-and-seroreversion-after-treatment-of-early-syphilis
#1
Arlene C Seña, Mark Wolff, Frieda Behets, David H Martin, Peter Leone, Carol Langley, Linda McNeil, Edward W Hook
BACKGROUND: Syphilis management is complex and demonstration of treatment response requires monitoring of nontreponemal antibody titers for a ≥ 4-fold decline and/or seroreversion to nonreactive titers. METHODS: We evaluated data from a multicenter clinical trial of syphilis treatment conducted from 2000 to 2009 involving human immunodeficiency virus (HIV)-negative patients 18 years or older with early syphilis. To assess the rate of titer decline and seroreversion after effective therapy, rapid plasma reagin (RPR) titers were analyzed at 1, 3, 6, 9, and 12 months among patients with an appropriate treatment response...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27847752/screw-in-forces-during-instrumentation-by-various-file-systems
#2
Jung-Hong Ha, Sang Won Kwak, Sung-Kyo Kim, Hyeon-Cheol Kim
OBJECTIVES: The purpose of this study was to compare the maximum screw-in forces generated during the movement of various Nickel-Titanium (NiTi) file systems. MATERIALS AND METHODS: Forty simulated canals in resin blocks were randomly divided into 4 groups for the following instruments: Mtwo size 25/0.07 (MTW, VDW GmbH), Reciproc R25 (RPR, VDW GmbH), ProTaper Universal F2 (PTU, Dentsply Maillefer), and ProTaper Next X2 (PTN, Dentsply Maillefer, n = 10). All the artificial canals were prepared to obtain a standardized lumen by using ProTaper Universal F1...
November 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27843564/bleeding-events-and-maintenance-dose-of-prasugrel-bless-pilot-study
#3
Nazario Carrabba, Guido Parodi, Rossella Marcucci, Renato Valenti, Anna Maria Gori, Angela Migliorini, Vincenzo Comito, Benedetta Bellandi, Rosanna Abbate, Gian Franco Gensini, David Antoniucci
OBJECTIVE: To evaluate changes in residual platelet reactivity (RPR) over time, and bleeding and ischaemic events rate using 5 vs 10 mg maintenance dose (MD) regimens of prasugrel 1 month after acute coronary syndrome (ACS). BACKGROUND: The optimal level of RPR with prasugrel may change over time after an ACS. METHODS: After 60 mg loading dose of prasugrel (T0) followed by 10 mg/day for 1 month, patients were randomised to receive prasugrel 10 mg/day (n=95, group A) or 5 mg/day MD (n=98, group B) up to 1 year...
2016: Open Heart
https://www.readbyqxmd.com/read/27822608/expression-of-anoctamins-in-retinal-pigment-epithelium-rpe
#4
Rainer Schreiber, Karl Kunzelmann
The anoctamin (ANO, TMEM16) family of Ca(2+)-activated Cl(-) channels consists of ten members with different cellular functions (ANO1-10). ANO1 is a Ca(2+)-activated Cl(-) channel in secretory epithelial cells of exocrine pancreas, salivary glands, or enterocytes. Expression of ANO1 also promotes cell proliferation and migration of tumor cells. ANO6 is essential for Ca(2+)-dependent scrambling of membrane phospholipids in platelets, red blood cells, and lymphocytes. ANO10 modulates Ca(2+) signals in macrophages and has a role in cerebellar ataxia and other neurological disorders...
November 7, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27787876/effect-of-a-long-term-physical-activity-intervention-on-resting-pulse-rate-in-older-persons-results-from-the-lifestyle-interventions-and-independence-for-elders-study
#5
Bríain Ó Hartaigh, Laura C Lovato, Marco Pahor, Thomas W Buford, John A Dodson, Daniel E Forman, Matthew P Buman, Jamehl L Demons, Adam J Santanasto, Christine Liu, Michael E Miller, Mary McGrae McDermott, Thomas M Gill
OBJECTIVES: To assess the utility of a long-term physical activity (PA) intervention for reducing resting pulse rate (RPR) in older persons. DESIGN: Community. SETTING: Lifestyle Interventions and Independence for Elders Study. PARTICIPANTS: Individuals aged 70 to 89 (N = 1,635, 67.2% women) were randomized to a moderate-intensity PA intervention (n = 818) or a health education-based successful aging (SA) intervention (n = 817)...
October 27, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27773873/performance-characteristics-of-the-reverse-syphilis-screening-algorithm-in-a-population-with-a-moderately-high-prevalence-of-syphilis
#6
Angela R Rourk, Frederick S Nolte, Christine M Litwin
OBJECTIVES: With the recent introduction of automated treponemal tests, a new reverse syphilis algorithm has been proposed and now used by many clinical laboratories. We analyzed the impact of instituting the reverse screening syphilis algorithm in a laboratory that serves a geographic area with a moderately high prevalence of syphilis infection. METHODS: Serum samples sent for syphilis testing were tested using a treponemal enzyme immunoassay (EIA) as the screening assay...
October 22, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27751728/macrophage-migration-inhibitory-factor-as-a-novel-cerebrospinal-fluid-marker-for-neurosyphilis-among-hiv-negative-patients
#7
Li-Rong Lin, Dan-Hong Lin, Man-Li Tong, Li-Li Liu, Jin-Yi Fan, Xiao-Zhen Zhu, Kun Gao, Mei-Jun Chen, Wei-Hong Zheng, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Jian-Jun Niu, Tian-Ci Yang
BACKGROUND: Neurosyphilis (NS) is difficult to diagnose, especially in syphilis patients with negative cerebrospinal fluid (CSF) rapid plasma reagin (RPR) or Venereal Disease Research Laboratory (VDRL) tests. METHODS: We conducted a cross-sectional study and an analysis of macrophage migration inhibitory factor (MIF) in syphilitic patients to identify a novel marker for the diagnosis of NS, with a focus on probable NS (NS with negative VDRL/RPR tests). For this purpose, CSF and serum MIF concentrations were determined in 43 NS and 43 syphilis/non-NS (N-NS) patients at the Zhongshan Hospital of the Medical College of Xiamen University from July 2014 to June 2015...
October 15, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27725694/three-dimensional-reconstruction-of-single-cell-chromosome-structure-using-recurrence-plots
#8
Yoshito Hirata, Arisa Oda, Kunihiro Ohta, Kazuyuki Aihara
Single-cell analysis of the three-dimensional (3D) chromosome structure can reveal cell-to-cell variability in genome activities. Here, we propose to apply recurrence plots, a mathematical method of nonlinear time series analysis, to reconstruct the 3D chromosome structure of a single cell based on information of chromosomal contacts from genome-wide chromosome conformation capture (Hi-C) data. This recurrence plot-based reconstruction (RPR) method enables rapid reconstruction of a unique structure in single cells, even from incomplete Hi-C information...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27723157/improving-the-screening-of-blood-donors-with-syphilis-rapid-diagnostic-test-rdt-and-rapid-plasma-reagin-rpr-in-low-and-middle-income-countries-lmic
#9
F Sarkodie, O Hassall, E Owusu-Dabo, S Owusu-Ofori, I Bates, I C Bygbjerg, A Owusu-Ofori, L H Harritshøj, H Ullum
BACKGROUND: Syphilis testing conventionally relies on a combination of non-treponemal and treponemal tests. The primary objective of this study was to describe the positive predictive value (PPV) of a screening algorithm in a combination of a treponemal rapid diagnostic test (RDT) and rapid plasma reagin (RPR) test at Komfo Anokye Teaching Hospital (KATH), Ghana. MATERIALS AND METHODS: From February 2014 to January 2015, 5 mL of venous blood samples were taken from 16 016 blood donors and tested with a treponemal RDT; 5 mL of venous blood was taken from 526 consenting initial syphilis sero-reactive blood donors...
October 10, 2016: Transfusion Medicine
https://www.readbyqxmd.com/read/27709684/diagnostic-validity-of-hematologic-parameters-in-evaluation-of-massive-pulmonary-embolism
#10
Hale Ates, Ihsan Ates, Harun Kundi, Fatma Meric Yilmaz
BACKGROUND: The aim of this study was to determine the hematologic parameter with the highest diagnostic differentiation in the identification of massive acute pulmonary embolism (APE). METHODS: A retrospective study was performed on patients diagnosing with APE between June 2014 and June 2016. All radiological and laboratory parameters of patients were scanned through the electronic information management system of the hospital. PLR was obtained from the ratio of platelet count to lymphocyte count, NLR was obtained from the ratio of neutrophil count to lymphocyte count, WMR was obtained from white blood cell in mean platelet volume ratio, MPR was obtained from the ratio of mean platelet volume to platelet count, and RPR was obtained from the ratio of red distribution width to platelet count...
October 6, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27669643/the-regrowth-kinetic-of-the-surviving-population-is-independent-of-acute-and-chronic-responses-to-temozolomide-in-glioblastoma-cell-lines
#11
Andrew Oliveira Silva, Eloisa Dalsin, Giovana Ravizzoni Onzi, Eduardo Cremonese Filippi-Chiela, Guido Lenz
Chemotherapy acts on cancer cells by producing multiple effects on a cell population including cell cycle arrest, necrosis, apoptosis and senescence. However, often a subpopulation of cells survives and the behavior of this subpopulation, which is responsible for cancer recurrence, remains obscure. Here we investigated the in vitro short- and long-term responses of six glioblastoma cell lines to clinically relevant doses of temozolomide for 5 days followed by 23 days of recovery, mimicking the standard schedule used in glioblastoma patient for this drug...
September 23, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27631362/associations-between-internalized-homophobia-and-sexual-risk-behaviors-among-young-black-men-who-have-sex-with-men
#12
Richard A Crosby, Laura F Salazar, Leandro Mena, Angelica Geter
OBJECTIVE: To assess internalized homophobia (IH) and its relationship to sexual risk behaviors and prevalence of sexually transmitted infection (STIs) in a clinic-based sample of young black men who have sex with men (YBMSM). METHODS: Six hundred YBMSM completed a self-interview and provided specimens for testing. A 7-item scale assessed IH, and 19 sexual risk behaviors were assessed. RESULTS: In adjusted models, compared with men with less IH, those with greater IH were more likely to report: any condomless anal receptive sex (P = 0...
October 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27618117/inhibition-of-bacterial-rnase-p-rna-by-phenothiazine-derivatives
#13
Shiying Wu, Guanzhong Mao, Leif A Kirsebom
There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities. Here, we show that different phenothiazine derivatives and pyronine G inhibited the activities of three structurally different bacterial RNase P RNAs (RPRs), including that from Mycobacterium tuberculosis, with Ki values in the lower μM range. Interestingly, three antipsychotic phenothiazines (chlorpromazine, thioridazine, and trifluoperazine), which are known to have antibacterial activities, also inhibited the activity of bacterial RPRs, albeit with higher Ki values than methylene blue...
September 8, 2016: Biomolecules
https://www.readbyqxmd.com/read/27602569/risk-factors-associated-with-incident-syphilis-in-a-cohort-of-high-risk-men-in-peru
#14
Hayoung Park, Kelika A Konda, Chelsea P Roberts, Jorge L Maguiña, Segundo R Leon, Jesse L Clark, Thomas J Coates, Carlos F Caceres, Jeffrey D Klausner
BACKGROUND: Syphilis is concentrated among high-risk groups, but the epidemiology of syphilis reinfection is poorly understood. We characterized factors associated with syphilis incidence, including reinfection, in a high-risk cohort in Peru. METHODS: Participants in the NIMH CPOL trial were assessed at baseline and 2 annual visits with HIV/STI testing and behavioral surveys. Participants diagnosed with syphilis also attended 4- and 9-month visits. All participants underwent syphilis testing with RPR screening and TPPA confirmation...
2016: PloS One
https://www.readbyqxmd.com/read/27566775/immune-reconstitution-inflammatory-syndrome-associated-with-secondary-syphilis
#15
Simona Frunza-Stefan, Gyanendra Acharya, Viktoryia Kazlouskaya, Paunel Vukasinov, Yushan Chiou, Zeyar Thet
Immune reconstitution inflammatory syndrome (IRIS) is a condition associated with paradoxical worsening and/or new onset of an opportunistic infection in HIV patients following the initiation of anti-retroviral therapy or switching to more potent antiretroviral therapy (ART) regimen. Although IRIS associated with many opportunistic infections (OIs) has been well reported, syphilis has very rarely been mentioned in this regard. A 52-year-old male, diagnosed with AIDS six weeks ago, presented with the disseminated non-pruritic painless skin rash...
August 26, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27551787/prevalence-of-active-and-latent-yaws-in-the-solomon-islands-18-months-after-azithromycin-mass-drug-administration-for-trachoma
#16
Michael Marks, Oliver Sokana, Eli Nachamkin, Elliot Puiahi, Georgina Kilua, Allan Pillay, Christian Bottomley, Anthony W Solomon, David C Mabey
INTRODUCTION: Both yaws and trachoma are endemic in the Pacific. Mass treatment with azithromycin is the mainstay of the WHO strategy for both the eradication of yaws and the elimination of trachoma as a public health problem, but the dose recommended for trachoma is lower than that for yaws. In countries where both diseases are endemic, there is a potential for synergy between yaws and trachoma control programs if mass treatment with the lower dose of azithromycin was shown to be effective for the treatment of yaws...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27531187/recall-of-symptoms-and-treatment-of-syphilis-and-yaws-by-healthy-blood-donors-screening-positive-for-syphilis-in-kumasi-ghana
#17
Francis Sarkodie, Ellis Owusu-Dabo, Oliver Hassall, Imelda Bates, Ib C Bygbjerg, Henrik Ullum
OBJECTIVE: To describe the recalled medical history, clinical manifestations, and treatment of yaws and syphilis by syphilis seroreactive blood donors in Kumasi, Ghana. METHODS: Of the blood donors at Komfo Anokye Teaching Hospital, Kumasi, Ghana tested with the syphilis rapid diagnostic test (RDT) and later by rapid plasma reagin (RPR) test, 526 were seroreactive. Four hundred and seventy-one (89.5%) of these subjects were confirmed with the Ortho-Vitros Syphilis TP test as the gold standard and were interviewed to determine past or present clinical manifestations of yaws and syphilis...
September 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27521818/characterization-and-quantification-of-monoterpenoids-in-different-types-of-peony-root-and-the-related-paeonia-species-by-liquid-chromatography-coupled-with-ion-trap-and-time-of-flight-mass-spectrometry
#18
Yan-Hong Shi, Shu Zhu, Yue-Wei Ge, Kazufumi Toume, Zhengtao Wang, Javzan Batkhuu, Katsuko Komatsu
Monoterpenoids with "cage-like" pinane skeleton are the unique and main bioactive constituents in peony root, the root of Paeonia lactiflora. A liquid chromatography coupled with ion trap and time-of-flight mass spectrometry (LC-IT-TOF-MS) method was developed for characterization and quantification of monoterpenoids in different types of peony root and the roots of related Paeonia species. MS/MS fragmentation patterns of monoterpenoids with paeoniflorin-, albiflorin- and sulfonated paeoniflorin-type of skeletons were elucidated, which provided basic clues enabling subsequent identification of 35 monoterpenoids in LC-MS profiles of Paeonia species...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27514511/the-availability-and-functional-status-of-focused-antenatal-care-laboratory-services-at-public-health-facilities-in-addis-ababa-ethiopia
#19
Daniel Melese Desalegn, Serebe Abay, Bineyam Taye
BACKGROUND: Provision of quality laboratory services is an essential aspect of a promoting safe motherhood and better outcomes for newborn. Therefore; this study was intended to assess status of focused antenatal care (FANC) laboratory services at public health facilities in Addis Ababa, Ethiopia. METHODS: Institution based, descriptive cross-sectional study was conducted from April to May 2015. The study included 13 randomly selected health facilities and 13 purposively selected laboratory service providers...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27476170/a-guide-for-the-analysis-of-long-term-population-growth-in-cancer
#20
Andrew O Silva, Karina B Felipe, Emilly S Villodre, Patricia L C Lopez, Guido Lenz
Although cancer is a chronic disease, most of the in vitro experiments to assess the effectiveness of intervention are performed in hours or a few days. Moreover, none of the available methodologies to measure cell proliferation are adapted to provide information about the growth kinetic during and after treatment. Thus, the objective of this work is to provide a guide to assess long-term changes in cell population size to be used mainly in cancer research. Cumulative population doubling (CPD) graphs based on cell counting for in vitro or tumor volume for in vivo assays were used to calculate four parameters: relative end CPD (RendCPD), to quantify the end point analysis of proliferation; relative area under curve (rAUC), to describe the global chronic effect of a treatment; relative time to cross a threshold (RTCT), to indicate the delay in cell population recovery produced by a treatment; and relative proliferation rate (RPR), to describe the relative regrowth velocity of the cells that survived after treatment...
July 31, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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