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Raynell Lang, Ron Read, Hartmut B Krentz, Soheil Ramazani, Mingkai Peng, Jennifer Gratrix, M John Gill
BACKGROUND: Syphilis is a global health concern disproportionately affecting HIV-infected populations. In Alberta, Canada, the incidence of syphilis in the general population has recently doubled with 25% of these infections occurring in HIV-infected patients. The Southern Alberta HIV Clinic (SAC) and Calgary STI Program (CSTI) analyzed the epidemiologic characteristics of incident syphilis infections in our well-defined, HIV-infected population over 11 years. METHODS: Since 2006, as routine practice of both the Southern Alberta Clinic (SAC) and Calgary STI Programs (CSTI), syphilis screening has accompanied HIV viral load measures every four months...
March 13, 2018: BMC Infectious Diseases
Xihui Jiang, Ya Wang, Zhengyan Su, Fang Yang, Houning Lv, Lin Lin, Chao Sun
We aimed to investigate the relationship between the histologic severity and red blood cell distribution width to platelet ratio (RPR) in patients with primary biliary cholangitis (PBC). One hundred and seven consecutive patients with liver biopsy-proven and as yet treatment-naïve PBC were enrolled as the primary and validation cohort. The histologic stages were divided into early stage (Scheuer's stage 1 & 2) and late stage (Scheuer's stage 3 & 4). The overall patient demographics, clinical manifestations, hematological tests and biochemical profile were retrospectively collected from our database...
March 13, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
(no author information available yet)
Chris S Earl, Teh Wooi Keong, Shi-qi An, Sarah Murdoch, Yvonne McCarthy, Junkal Garmendia, Joseph Ward, J Maxwell Dow, Liang Yang, George A O'Toole & Robert P RyanThe above article, published May 20 2015 in EMBO Molecular Medicine , has been retracted by agreement between the authors of the study, CSE, TWK, SQA, SM, YMcC, JG, JW, JMD, LY, RPR, the journal Chief Editor and the EMBO Head of Scientific Publications in accordance with the outcomes of independent investigations conducted by the University of Dundee and University College Cork...
March 12, 2018: EMBO Molecular Medicine
Calleb George Onyango, Lilian Ogonda, Bernard Guyah, Peter Okoth, Clement Shiluli, Felix Humwa, Vallarie Opollo
OBJECTIVE: Since the implementation of a series of blood donation safety improvements in Kenya, information about seroprevalence and determinants of transfusion transmissible infections among voluntary blood donors especially in high HIV burden regions of Homabay, Kisumu and Siaya counties remain scanty. A cross-sectional study examining HIV, syphilis, hepatitis B and C virus sero-markers and associated determinants was conducted among voluntary blood donors. Their demographic characteristics and previous risk exposure were recorded in a pre-donation questionnaire, while blood samples collected were screened for hepatitis B, hepatitis C, human immunodeficiency viruses by ELISA and RPR (syphilis), then confirmed using CMIA...
March 12, 2018: BMC Research Notes
Fatemeh Jahanbakhsh, Fahimeh Bagheri Amiri, Abbas Sedaghat, Noushin Fahimfar, Ehsan Mostafavi
BACKGROUND: This study investigated the prevalence for hepatitis A virus (HAV), hepatitis E virus (HEV), herpes simplex virus type 2 (HSV2) and syphilis among homeless in the city of Tehran. METHODS: In this cross-sectional study, 596 homeless were recruited in Tehran. A researcher-designed questionnaire was used to study demographic data. Using enzyme-linked immunoassay, and rapid plasma reagin (RPR) test, we evaluated the seroprevalence of HAV anti-body, HEV IgG, herpes, HSV2 IgG, and syphilis among sheltered homeless in Tehran...
July 8, 2017: International Journal of Health Policy and Management
Anteneh Amsalu, Getachew Ferede, Demissie Assegu
BACKGROUND: Despite availability of effective treatment and the implementation of focused antenatal care (ANC), still the prevalence of syphilis persists in Ethiopia. Yet, data is not found in southern Ethiopia. Therefore, this study was conducted to determine the seroprevalence and associated factors of syphilis among pregnant women in Yiregalem Hospital, Southern Ethiopia. METHODS: A cross-sectional study was conducted among pregnant women from October 2015 to August 2016...
March 6, 2018: BMC Infectious Diseases
Guanzhong Mao, Abhishek S Srivastava, Shiying Wu, David Kosek, Magnus Lindell, Leif A Kirsebom
The natural trans-acting ribozyme RNase P RNA (RPR) is composed of two domains in which the catalytic (C-) domain mediates cleavage of various substrates. The C-domain alone, after removal of the second specificity (S-) domain, catalyzes this reaction as well, albeit with reduced efficiency. Here we provide experimental evidence indicating that efficient cleavage mediated by the Escherichia coli C-domain (Eco CP RPR) with and without the C5 protein likely depends on an interaction referred to as the "P6-mimic"...
2018: PloS One
Yukiko Komeno, Yasunori Ota, Tomohiko Koibuchi, Yoichi Imai, Kuniko Iihara, Tomiko Ryu
BACKGROUND Syphilis is a sexually transmitted disease caused by the pathogen Treponema pallidum. Prevalence continues to rise, especially among men who have sex with men (MSM). Due to changes in patterns of sexual activity, manifestations of the disease are highly variable. CASE REPORT A 27-year-old male visited the hospital for a low-grade fever and tender 5-cm mass in the right side of his neck. His right tonsil was swollen and covered with a white coating. Levofloxacin was prescribed, but ineffective. The patient's levels of liver function enzymes increased gradually...
March 4, 2018: American Journal of Case Reports
Justin A Kraft, Matthew L Laurent, James Matthew Green, Jessica Helm, Cooper Roberts, Swan Holt
Monitoring training and recovery are essential for exercise programming. Athletes can validly assess training load (TL) via the session rating of perceived exertion (SRPE) technique. However, it is unclear if coaches can successfully use this model. PURPOSE: This study compared coach and athlete perceptions of effort and recovery and evaluated the efficacy of perceptually-based TL monitoring. METHODS: Participants included 56 athletes (Women's volleyball, soccer, and basketball and Men's basketball) and their coaches (n = 4)...
February 27, 2018: Journal of Strength and Conditioning Research
Anna Brischetto, Ian Gassiep, David Whiley, Robert Norton
There has been a resurgence of syphilis diagnoses in Australia. We investigated whether our Treponema pallidum polymerase chain reaction (PCR) test provides any additional diagnostic information over syphilis serology (chemi-luminescence immunoassay (CMIA), Treponema pallidum particle agglutination (TPPA) and rapid reagin (RPR) flocculation test). A retrospective audit was conducted of all T. pallidum PCR requests that came through our laboratory from January 2010 to June 2017; data collected included age, gender, site of swab, T...
February 14, 2018: Journal of Clinical Microbiology
Zhongfeng Wang, Xu Liu, Hongqin Xu, Limei Qu, Dezhi Zhang, Pujun Gao
The aim of this study was to evaluate the ability of noninvasive markers to identify the histological severity of primary biliary cholangitis (PBC).Fifty-eight treatment-naïve PBC patients who had undergone liver biopsy were enrolled in our study. The patients' histological stages were based on the classifications of Ludwig and Scheuer. Aspartate aminotransferase-to-platelet ratio index (APRI), fibrosis index based on the 4 factors (FIB-4), red blood cell distribution width to platelet ratio (RPR), and platelet count to spleen thickness (PC/ST) ratio were calculated...
February 2018: Medicine (Baltimore)
Mohammed Tag-Adeen, Maha Zeinelabedin Omar, Fatma Mohamed Abd-Elsalam, Ali Hasaneen, Mohamed Ahmed Mohamed, Hala Mohamed Elfeky, Ebada Mohamed Said, Badawy Abdul-Aziz, Amira Hefney Osman, Enas Sebaey Ahmed, Ghada Sidky Osman, Taghreed Abdul-Samie
Fibrosis assessment in chronic hepatitis B (CHB) is essential for prediction of long-term prognosis and proper treatment decision. This study was conducted to assess predictability of 5 simple noninvasive fibrosis indexes in comparison to liver biopsy in CHB patients.A total of 200 CHB adult Egyptian patients were consecutively included in this study, all were subjected to liver biopsy with staging of fibrosis using METAVIR scoring system. Fibrosis indexes including S-index, red cell distribution width to platelets ratio index (RPR), fibrosis-4 index (Fib-4), AST to platelets ratio index (APRI), and AST/ALT ratio index (AAR) were compared to biopsy result and their predictabilities for the different fibrosis stages were assessed using area under receiver operating characteristic curve (AUROC) analysis...
February 2018: Medicine (Baltimore)
David Haldrup, Sara Heebøll, Karen Louise Thomsen, Kasper Jarlhelt Andersen, Michelle Meier, Frank Viborg Mortensen, Jens Randel Nyengaard, Stephen Hamilton-Dutoit, Henning Grønbæk
AIM: To evaluate the liver regeneration capacity (LRC) after partial hepatectomy (PH) in experimental non-alcoholic steatohepatitis (NASH). METHODS: Fifty-four female rats were fed a high-fat, high-cholesterol diet (HFCD, 65% fat, 1% cholesterol) or standard diet (STD) for 16 wk. A 70% PH was performed and the animals were euthanised before PH or 2 or 5 d post-PH. LRC was evaluated using: The total number of Ki-67 positive hepatocytes in the caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, the regenerated protein ratio (RPR), prothrombin-proconvertin ratio (PP), and mRNA expression of genes related to regeneration...
January 27, 2018: World Journal of Hepatology
Tanmoy Mondal, Indira Bag, Pushpavalli Sncvl, Koteswara Rao Garikapati, Utpal Bhadra, Manika Pal Bhadra
Argonaute family proteins are well conserved among all organisms. Its role in mitotic cell cycle progression and apoptotic cell elimination is poorly understood. Earlier we have established the contribution of Ago-1 in cell cycle control related to G2/M cyclin in Drosophila. Here we have extended our study in understanding the relationship of Ago-1 in regulating apoptosis during Drosophila development. Apoptosis play a critical role in controlling organ shape and size during development of multi cellular organism...
2018: PloS One
Xiaojuan Wu, Bei Cai, Zhenzhen Su, Yamei Li, Jin Xu, Rong Deng, Lanlan Wang
BACKGROUND: The benefits of using serum markers to diagnose stages of liver disease in chronic hepatitis B (CHB) patients are controversial. We conducted a study to compare the clinical significance of four markers in evaluating liver inflammation and fibrosis in CHB patients. METHODS: A total of 323 treatment-naive CHB patients who received a liver biopsy and routine laboratory testing were enrolled in our study. We used the Scheuer scoring system as a pathological standard for diagnosing liver inflammation and fibrosis...
December 18, 2017: Journal of Clinical Laboratory Analysis
Antonella Zorzi, Maddalena Cordioli, Lorenzo Gios, Paola Del Bravo, Igor Toskin, Rosanna W Peeling, Karel Blondeel, Giuseppe Cornaglia, James Kiarie, Ronald Ballard, Massimo Mirandola
OBJECTIVES: The incidence of HIV and syphilis among men who have sex with men (MSM) in Europe has recently increased. Rapid point-of-care tests (POCTs) for syphilis can improve access to screening. The purpose of this study was to evaluate the performance of two syphilis POCTs compared with laboratory tests among MSM. METHODS: The study was undertaken in Verona, Italy. Asymptomatic MSM, potentially exposed to syphilis, were enrolled prospectively. The POCTs evaluated were SD Bioline Syphilis 3...
December 2017: Sexually Transmitted Infections
Ellen M K Warlo, Alf-Åge R Pettersen, Harald Arnesen, Ingebjørg Seljeflot
Background: The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated levels of von Willebrand factor (vWF). ADAMTS13 is a metalloprotease cleaving ultra large vWF multimers into less active fragments.Our aim was to investigate whether ADAMTS13 and vWF/ADAMTS13 ratio were associated with high RPR, and further with clinical endpoints after 2 years...
2017: Thrombosis Journal
Jung-In Kim, Ji-Hye Park, Ju-Yeon Choi, Ga-Young Lee, Won-Serk Kim
Background: Automated analyzer-based nontreponemal serological tests for syphilis (STS) have been used for several decades. Objective: In this study, we evaluated serological responses to treatment and proposed clinical guidelines for automated STS. Methods: This retrospective cohort study analyzed human immunodeficiency virus-negative syphilis patients who were diagnosed with automated rapid plasma reagin (auto RPR) tests as a nontreponemal STS, and who also received the fluorescent treponemal antibody-absorption test as a confirmatory test...
December 2017: Annals of Dermatology
Miranda Sherley, Sarah Jane Martin
Multiple concurrent infectious processes have previously been reported in the context of advanced HIV with significant immunosuppression. Here we report a case of multiple infections in a 56-year-old man with well-controlled HIV diagnosed 5 years earlier. Soon after returning to Australia following 12 years living in Thailand, he became unwell with fevers, night sweats, arthralgia and myalgia. There were no localising symptoms and examination was unremarkable. Investigations revealed positive syphilis ( Treponema pallidum ) serology with an RPR of 16, a positive urine culture ( Klebsiella pneumoniae ), a pulmonary nodule, a liver abscess and colitis ( Entamoeba histolytica )...
December 1, 2017: BMJ Case Reports
Shaily B Surti, J K Kosambiya, Neeta Khokhar, Mohamedanas Mohamedfaruk Patni, Alpesh H Gohil, Zeel N Kamdar, Dipak Umrigar, Ragini Verma, Summaiya Mulla
Background: Outbreak of syphilis, i.e., 16 cases of rapid plasma reagin (RPR) reactive cases of syphilis was reported in Community Based Organization (CBO) Sahyog of Surat, India, from April to August 2014. The aim of the study was to find risk factors and take immediate actions to prevent spread. Materials and Methods: Outbreak investigation of 16 Female Sex Workers of CBO Sahyog in Surat who were found Rapid Plasma Reagin (RPR) and Treponema Pallidum Hemagglutination Assay (TPHA) positive from April to August 2014; was carried out...
October 2017: Indian Journal of Community Medicine
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