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https://www.readbyqxmd.com/read/29770281/intestinal-spirochetosis-in-an-immunocompetent-patient
#1
Patricia Guzman Rojas, Jelena Catania, Jignesh Parikh, Tran C Phung, Glenn Speth
Intestinal spirochetosis (IS) is an infestation defined by the presence of spirochetes on the surface of the colonic mucosa. The implicated organisms can be Brachyspira aalborgi or Brachyspira pilosicoli . We present the case of a 66-year-old man with a past medical history of diabetes mellitus, hypertension, morbid obesity, and gastroesophageal reflux. The patient was sent to the gastroenterology clinic for a screening colonoscopy due to a prior history of colonic polyps. The patient was completely asymptomatic as he denies any abdominal pain, diarrhea, melena, or hematochezia...
March 15, 2018: Curēus
https://www.readbyqxmd.com/read/29740769/degradation-of-carbendazim-in-water-via-photo-fenton-in-raceway-pond-reactor-assessment-of-acute-toxicity-and-transformation-products
#2
Elizângela Pinheiro da Costa, Sue Ellen C Bottrel, Maria Clara V M Starling, Mônica M D Leão, Camila Costa Amorim
This study aimed at investigating the degradation of fungicide carbendazim (CBZ) via photo-Fenton reactions in artificially and solar irradiated photoreactors at laboratory scale and in a semi-pilot scale Raceway Pond Reactor (RPR), respectively. Acute toxicity was monitored by assessing the sensibility of bioluminescent bacteria (Aliivibrio fischeri) to samples taken during reactions. In addition, by-products formed during solar photo-Fenton were identified by liquid chromatography coupled to mass spectrometry (UFLC-MS)...
May 8, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29739928/sensitive-detection-of-treponema-pallidum-dna-from-the-whole-blood-of-patients-with-syphilis-by-the-nested-pcr-assay
#3
Cuini Wang, Yuanyuan Cheng, Biao Liu, Yuanyuan Wang, Weiming Gong, Yihong Qian, Zhifang Guan, Haikong Lu, Xin Gu, Mei Shi, Pingyu Zhou
The aim of this work was to investigate the application of the nested PCR assay for the detection of Treponema pallidum (TP) DNA from the blood of patients with different stages of syphilis. In this study, a nested PCR method targeting the Tpp47 and polA genes (Tpp47-Tp-PCR and polA-Tp-PCR) was developed to detect TP-DNA in whole blood samples collected from 262 patients with different stages of syphilis (84 primary syphilis, 97 secondary syphilis, and 81 latent syphilis patients). The PCR assay detected T...
May 9, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29719831/a-30-year-old-man-with-hiv-fever-and-a-rash
#4
Radhika Shah, Saami Khalifian, Lyn Duncan, Daniela Kroshinsky, Bonnie Mackool
Patients who present with papular rashes have a wide differential diagnosis particularly in the setting of immune compromise. A 30-year-old male diagnosed with HIV since 2009, never on antiretroviral therapy, with a nadir CD4 count of 333 cells/mm3 and a current viral load of 44,300 copies/mL, presented with a diffuse monomorphic papular eruption that began on his trunk and extremities and subsequently spread to the penis and scrotum, sparing the distal acral sites. A thorough infectious workup revealed a positive rapid plasma reagin (RPR) and varicella IgM and IgG antibodies...
January 2018: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29688864/radix-paeoniae-rubra-stimulates-osteoclast-differentiation-by-activation-of-the-nf-%C3%AE%C2%BAb-and-mitogen-activated-protein-kinase-pathways
#5
Huey-En Tzeng, Chun-Hao Tsai, Tin-Yun Ho, Chin-Tung Hsieh, Shen-Chieh Chou, Yi-Ju Lee, Gregory J Tsay, Po-Hao Huang, Yi-Ying Wu
BACKGROUND: Radix Paeoniae Rubra (RPR), a traditional Chinese herb, has anti-inflammatory and immuno-regulatory properties. This study explored the effects of RPR on stimulation of osteoclast differentiation in RAW264.7 cells and peripheral blood mononuclear cells (PBMC)s. METHODS: The mature osteoclasts were measured by bone resorption assays and TRAP staining. JNK, ERK, p38 and NF-κB inhibitors were used applied in order to verify their contribution in RPR-induced osteoclast differentiation...
April 23, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29676865/detecci%C3%A3-n-de-treponema-pallidum-subespecie-pallidum-para-el-diagn%C3%A3-stico-de-s%C3%A3-filis-cong%C3%A3-nita-mediante-reacci%C3%A3-n-en-cadena-de-la-polimerasa-anidada
#6
Gladys Pinilla, Lesly Campos, Andrea Durán, Jeannette Navarrete, Liliana Muñoz
Introducción. La sífilis es una enfermedad producida por Treponema pallidum subespecie pallidum cuya incidencia mundial es de 12 millones de casos por año, aproximadamente; de estos, más de dos millones se presentan en mujeres gestantes, siendo la sífilis congénita la complicación más grave de esta infección en el embarazo.Objetivo. Detectar la presencia de T. pallidum subespecie pallidum en muestras clínicas para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa (PCR) anidada y determinar su concordancia con las pruebas serológicas...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29629652/utility-of-antitreponemal-igm-testing-in-the-diagnosis-of-early-and-repeat-syphilis-among-hiv-infected-and-non-infected-patients
#7
Maciej Pastuszczak, Agnieszka Kotnis-Gąska, Bernadetta Jakubowicz, Iwona Martyka, Monika Bociaga-Jasik, Anna Wojas-Pelc
Until now only non-treponemal tests (e.g. rapid plasma reagin [RPR]) have been used to monitor syphilis activity (e.g. distinguishing between treated, untreated and repeat disease) and efficacy of treatment. However, they usually require manual operation and are less specific than treponemal tests. The aim of the current study was to evaluate the use of the antitreponemal IgM testing in the diagnosis of early and repeat syphilis in HIV-infected and non-infected patients. One hundred and seventeen patients with early syphilis were included in this prospective study...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29618500/comparison-of-manual-and-fully-automated-aix1000-rapid-plasma-reagin-assays-for-the-laboratory-diagnosis-of-syphilis
#8
Alan M Sanfilippo, Kristie Freeman, John L Schmitz
The analytic performance of the AIX1000, a fully automated and recently FDA cleared rapid plasma reagin (RPR) system, was evaluated by comparison to a manual RPR test in a traditional syphilis testing algorithm. 1,028 consecutive serum samples submitted for syphilis testing to the University of North Carolina Hospitals Clinical Immunology Laboratory were tested per each manufacturer's instructions. 996 samples were nonreactive and 20 were reactive using both the ASI RPR Card System and the AIX1000. Of the 12 discrepant specimens, 11 were AIX1000 reactive and ASI Card nonreactive while 1 specimen was ASI Card reactive and AIX1000 nonreactive...
April 4, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29615297/is-there-synergy-in-syndemics-psychosocial-conditions-and-sexual-risk-among-men-who-have-sex-with-men-in-india
#9
Cecilia Tomori, Allison M McFall, Sunil S Solomon, Aylur K Srikrishnan, Santhanam Anand, P Balakrishnan, Shruti H Mehta, David D Celentano
Syndemic theory describes the clustering and synergistic interaction of disease driven by contextual and social factors, which worsen health outcomes for a population, and has been applied to men who have sex with men (MSM) and their risk for HIV and other sexually transmitted infections. Recent reviews, however, have critiqued prevailing approaches in syndemic studies that assess only additive associations without evaluation of synergy. Following these suggestions, we compared the traditional additive approach with a test for synergistic association of 5 syndemic conditions (alcohol dependence, illicit drug use, depression, intimate partner violence (IPV), and childhood sexual abuse (CSA)) with unprotected anal intercourse (UAI) and active syphilis infection among 11,771 MSM recruited through respondent driven sampling from 12 cities in India...
March 23, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29606102/the-performance-of-rapid-plasma-reagin-rpr-titer-in-hiv-negative-general-paresis-after-neurosyphilis-therapy
#10
Ying Jiang, Ruihui Weng, Yuefeng Zhang, Rong Fan, Yulun Liu, Zhigang Chen, Fuhua Peng, Yong Chen, Xiaohong Chen
BACKGROUND: Repeated nontreponemal serologic test for syphilis titers is recommended to evaluate treatment response. However, it is unknown whether serum rapid plasma reagin (RPR) titer can serve as a surrogate for determining the efficacy of treatment in general paresis (GP) remains unknown. METHODS: We retrospectively reviewed data from 105 GP patients, who were divided into two groups (62 CSF RPR+ patients and 43 CSF RPR- patients) according to reactive RPR test status in CSF...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29603401/platelet-to-lymphocyte-ratio-in-acute-aortic-dissection
#11
Eftihia Sbarouni, Panagiota Georgiadou, Elias Kosmas, Antonis Analitis, Vassilis Voudris
BACKGROUND: Inflammation plays an important role in the initiation and progression of acute aortic dissection (AAD). New inflammatory indices derived from full cell blood count and its differential may be associated with increased risk. We evaluated platelet-lymphocyte (PLR), red cell distribution width (RDW) and RDW/PLT's (platelets) (RPR) in AAD. METHODS: We studied 120 consecutive patients with AAD type I admitted for emergency surgery (group I), 121 consecutive patients with aortic aneurysms of the ascending aorta prior to elective repair (group II) and 121 controls (group III), age and sex matched...
March 30, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29596225/use-of-oral-fluid-with-a-rapid-treponemal-test-for-syphilis-evaluation
#12
Claire C Bristow, Chelsea Shannon, Sasha Herbst de Cortina, Jeffrey D Klausner
We aimed to determine if rapid treponemal tests intended for whole blood specimens could be used to detect treponemal antibody in oral fluid. We found a high sensitivity of oral fluid rapid testing, which increased with increasing RPR titer, suggesting potential for the development of accurate rapid oral syphilis tests.
March 29, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29590085/factors-affecting-mortality-in-elderly-patients-who-underwent-surgery-for-gastric-cancer
#13
Selami Ilgaz Kayılıoglu, Ufuk Utku Göktug, Tolga Dinc, Isa Sozen, Zeynep Yavuz, Faruk Coskun
AIM: The aim of this study was to determine factors affecting overall mortality in patients over 60 years of age who underwent surgery for gastric cancer in our clinic. MATERIAL AND METHODS: Data on histopathological diagnosis (tumor size, lymph node status, and number), pathological stage, serum albumin level, tumor markers, complete blood count, and demographic information of 109 patients over 60 years of age who had surgery for gastric cancer between January 2011 and July 2016 were obtained retrospectively from the patient files...
March 5, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29582222/pre-analytical-factors-influence-accuracy-of-urine-spot-iodine-assessment-in-epidemiological-surveys
#14
Radhouene Doggui, Myriam El Ati-Hellal, Pierre Traissac, Jalila El Ati
Urinary iodine concentration (UIC) is commonly used to assess iodine status of subjects in epidemiological surveys. As pre-analytical factors are an important source of measurement error and studies about this phase are scarce, our objective was to assess the influence of urine sampling conditions on UIC, i.e., whether the child ate breakfast or not, urine void rank of the day, and time span between last meal and urine collection. A nationwide, two-stage, stratified, cross-sectional study including 1560 children (6-12 years) was performed in 2012...
March 26, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29547908/an-emergency-department-presentation-of-secondary-syphilis
#15
Simon A Sarkisian, Daniel Brillhart
In the United States, the rate of primary and secondary syphilis has increased by 18% in 2016, the highest rate since 1993. These patients can often present to the emergency department (ED) in various stages. Although syphilis is well described in the literature, there is a paucity of ED reports of atypical cases. A 22-yr-old male presented to the ED complaining of neck pain. The patient was found to have right-sided tender cervical lymphadenopathy causing neck pain. A thorough physical exam revealed diffuse lymphadenopathy...
March 14, 2018: Military Medicine
https://www.readbyqxmd.com/read/29547628/changing-seroprevalence-of-hepatitis-c-virus-infection-among-hiv-positive-patients-in-taiwan
#16
Chia-Wen Li, Chia-Jui Yang, Hsin-Yun Sun, Mao-Song Tsai, Shih-Ping Lin, Te-Yu Lin, Chien-Yu Cheng, Yi-Chien Lee, Yu-Shan Huang, Chun-Eng Liu, Yuan-Ti Lee, Hung-Jen Tang, Ning-Chi Wang, Shu-Hsing Cheng, Wen-Chien Ko, Chien-Ching Hung
OBJECTIVE: The study aimed to describe the evolution of the seroprevalence of hepatitis C virus (HCV) among human immunodeficiency virus (HIV)-positive patients included in two cohorts in Taiwan. METHODS: We retrospectively collected the information on demographic and clinical characteristics of 4,025 and 3,856 HIV-positive Taiwanese, who were aged 18 years or older at designated hospitals around Taiwan in 2004-2007, when an outbreak of HIV infection was occurring, and 2012-2016, when the outbreak was controlled with the implementation of harm reduction program, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29534681/increasing-incidence-of-syphilis-among-patients-engaged-in-hiv-care-in-alberta-canada-a-retrospective-clinic-based-cohort-study
#17
Raynell Lang, Ron Read, Hartmut B Krentz, Soheil Ramazani, Mingkai Peng, Jennifer Gratrix, M John Gill
BACKGROUND: Syphilis is a global health concern disproportionately affecting HIV-infected populations. In Alberta, Canada, the incidence of syphilis in the general population has recently doubled with 25% of these infections occurring in HIV-infected patients. The Southern Alberta HIV Clinic (SAC) and Calgary STI Program (CSTI) analyzed the epidemiologic characteristics of incident syphilis infections in our well-defined, HIV-infected population over 11 years. METHODS: Since 2006, as routine practice of both the Southern Alberta Clinic (SAC) and Calgary STI Programs (CSTI), syphilis screening has accompanied HIV viral load measures every four months...
March 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29533114/red-blood-cell-distribution-width-to-platelet-ratio-levels-in-assessment-of-histologic-severity-in-patients-with-primary-biliary-cholangitis
#18
Xihui Jiang, Ya Wang, Zhengyan Su, Fang Yang, Houning Lv, Lin Lin, Chao Sun
We aimed to investigate the relationship between the histologic severity and red blood cell distribution width to platelet ratio (RPR) in patients with primary biliary cholangitis (PBC). One hundred and seven consecutive patients with liver biopsy-proven and as yet treatment-naïve PBC were enrolled as the primary and validation cohort. The histologic stages were divided into early stage (Scheuer's stage 1 & 2) and late stage (Scheuer's stage 3 & 4). The overall patient demographics, clinical manifestations, hematological tests and biochemical profile were retrospectively collected from our database...
March 13, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29531022/retraction-haemophilus-influenzae-responds-to-glucocorticoids-used-in-asthma-therapy-by-modulation-of-biofilm-formation-and-antibiotic-resistance
#19
(no author information available yet)
Chris S Earl, Teh Wooi Keong, Shi-qi An, Sarah Murdoch, Yvonne McCarthy, Junkal Garmendia, Joseph Ward, J Maxwell Dow, Liang Yang, George A O'Toole & Robert P RyanThe above article, published May 20 2015 in EMBO Molecular Medicine , has been retracted by agreement between the authors of the study, CSE, TWK, SQA, SM, YMcC, JG, JW, JMD, LY, RPR, the journal Chief Editor and the EMBO Head of Scientific Publications in accordance with the outcomes of independent investigations conducted by the University of Dundee and University College Cork...
April 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29530086/seroprevalence-and-determinants-of-transfusion-transmissible-infections-among-voluntary-blood-donors-in-homabay-kisumu-and-siaya-counties-in-western-kenya
#20
Calleb George Onyango, Lilian Ogonda, Bernard Guyah, Peter Okoth, Clement Shiluli, Felix Humwa, Vallarie Opollo
OBJECTIVE: Since the implementation of a series of blood donation safety improvements in Kenya, information about seroprevalence and determinants of transfusion transmissible infections among voluntary blood donors especially in high HIV burden regions of Homabay, Kisumu and Siaya counties remain scanty. A cross-sectional study examining HIV, syphilis, hepatitis B and C virus sero-markers and associated determinants was conducted among voluntary blood donors. Their demographic characteristics and previous risk exposure were recorded in a pre-donation questionnaire, while blood samples collected were screened for hepatitis B, hepatitis C, human immunodeficiency viruses by ELISA and RPR (syphilis), then confirmed using CMIA...
March 12, 2018: BMC Research Notes
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