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https://www.readbyqxmd.com/read/29138654/syphilis-and-hiv-infections-among-pregnant-women-attending-antenatal-clinics-in-republic-of-congo
#1
Roch Fabien Niama, Nadia Claricelle Loukabou Bongolo, Edith Sophie Bayonne Kombo, Ruth Yengo, Pembe Issamou Mayengue, Etoka-Beka Mandingha Kosso, Igor Louzolo, Lucette Macosso, Ghislain Dzeret, Angélie Serge Patrick Dzabatou Babeaux, Marie-Francke Puruehnce, Henri Joseph Parra
Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. Methods: A study was conducted in 44 selected ANCs from 12 departments (5 urban and 7 rural). Pregnant women who accepted to participate in the study, attending selected sentinel ANCs sites for the first time between September and December 2011 were enrolled...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29136161/trends-and-predictors-of-syphilis-prevalence-in-the-general-population-global-pooled-analyses-of-1103-prevalence-measures-including-136-million-syphilis-tests
#2
Alex Smolak, Jane Rowley, Nico Nagelkerke, Nicholas J Kassebaum, R Matthew Chico, Eline L Korenromp, Laith J Abu-Raddad
Background: This study assessed levels, trends, and associations of observed syphilis prevalence in the general adult population using global pooled analyses. Methods: A standardized database of syphilis prevalence was compiled by pooling systematically-gathered data. Random-effects meta-analyses and meta-regressions were conducted using data from 1990-2016 to estimate pooled measures and assess predictors and trends. Countries were classified by World Health Organization regions...
November 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29133821/incidence-of-asymptomatic-neurosyphilis-in-serofast-chinese-syphilis-patients
#3
Sheng Nan Cai, Jing Long, Chen Chen, Gang Wan, Wen Hui Lun
More new diagnosed syphilis cases were reported in china, the incidence and relevant factors of asymptomatic neurosyphilis (ANS) in serofast syphilis patients were unclear. Clinical and laboratory data of 402 Human Immunodeficiency Virus (HIV) negative, serofast syphilis patients, who underwent lumbar puncture at the Peking University Ditan Teaching Hospital between September 2008 and August 2016, were collected. Incidence of ANS was verified and the relevant factors were further analyzed. According to the ANS criteria, 139 (34...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29107589/metamizole-and-platelet-inhibition-by-aspirin-following-on-pump-coronary-artery-bypass-grafting
#4
Mirosław Wilczyński, Maciej T Wybraniec, Marek Sanak, Joanna Góral, Katarzyna Mizia-Stec
OBJECTIVE: The purpose of the study was to evaluate the impact of intravenous metamizole on platelet inhibition by aspirin in patients with coronary artery disease early after on-pump coronary artery bypass grafting (CABG). DESIGN: Prospective, single-blind, randomized trial. SETTING: Tertiary referal hospital. PARTICIPANTS: The study comprised 43 patients with multivessel coronary artery disease undergoing CABG. INTERVENTIONS: Patients were randomized to postoperative intravenous metamizole ± opioids (study group; n = 23) or opioids alone (control group; n = 20)...
June 7, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29076438/stevens-johnson-syndrome-versus-jarisch-herxheimer-reaction-in-an-hiv-positive-patient-with-secondary-syphilis
#5
Sarah Micozzi, Patricia Rojas Perez-Ezquerra, Cristina Morales-Cabeza, Cristina Diez, Manuel De Barrio
BACKGROUND: HIV positive patients can suffer many complications due to infectious diseases. A severe reaction to some of the drugs involved in the treatment can overlap with the symptoms of infections, making diagnosis very difficult. We present the case of an HIV positive 28-year-old-man, , with secondary syphilis, who developed a Stevens Johnson Syndrome (SJS) caused by one of the many drugs he was receiving. The SJS overlapped with a possible Jarisch Herxheimer Reaction, which complicated diagnosis of the skin reaction...
October 26, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29057939/prognostic-values-of-red-blood-cell-distribution-width-platelet-count-and-red-cell-distribution-width-to-platelet-ratio-for-severe-burn-injury
#6
Le Qiu, Chen Chen, Shi-Ji Li, Chao Wang, Feng Guo, April Peszel, Sheng Liu, Fei Wang, Ye-Xiang Sun, Yong-Jie Wang, Xu-Lin Chen
Red blood cell distribution width (RDW), platelet count (PLT), and a RDW-to-PLT ratio (RPR) have been associated with inflammatory activity and adverse outcomes in many diseases. This study has aimed to investigate the association between these indicators and the mortality rate of severe burn patients. From 2008 to 2014, 610 cases of severe burn patients from two burn centers in eastern China were enrolled in this study. Eighty-eight patients died within 90 days after admission. The RDW, PLT, and RPR were studied through Cox regression analysis on the 3rd and 7th day...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29053397/combined-intravitreal-and-systemic-antibiotic-therapy-in-a-patient-with-syphilitic-uveitis
#7
Arjun B Sood, William A Pearce, Kimberly A Workowski, James Lockwood, Steven Yeh
PURPOSE: To report the novel use of combined intravitreal and systemic antibiotic therapy in a patient with syphilitic panuveitis and discuss the management of ocular syphilis. METHODS: Case report Results: A 45-year old heterosexual male with human immunodeficiency virus (HIV) presented with 1 month of blurry vision in both eyes. Clinical examination revealed a bilateral panuveitis. The patient denied history of genital lesions or rash, but did complain of difficulty hearing bilaterally...
October 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29046410/correlation-of-treponemal-immunoassay-signal-strength-values-with-reactivity-of-confirmatory-treponemal-testing
#8
Yetunde F Fakile, Heather Jost, Karen W Hoover, Kathleen J Gustafson, Susan M Novak-Weekley, Jeff M Schapiro, Anthony Tran, Joan M Chow, Ina U Park
Automated treponemal immunoassays are used for syphilis screening with the reverse sequence algorithm; discordant results (e.g., enzyme immunoassay [EIA]-reactive, reactive plasma reagin [RPR]-non-reactive) are resolved with a second treponemal test. We conducted a study to determine automated immunoassay signal strength values consistently correlating with reactive confirmatory treponemal testing.We conducted a cross-sectional analysis of four automated immunoassays: BioPlex 2200 microbead immunoassay (MBIA), LIAISON chemiluminesence immunoassay (CIA), ADVIA-Centaur CIA, and TrepSure EIA, and three manual assays: Treponema Pallidum Particle Agglutination (TP-PA), Fluorescent Treponemal Antibody-Absorption (FTA-ABS) test, INNO-LIA line immunoassay...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29026177/divergent-drivers-of-the-spatial-and-temporal-variations-of-cropland-carbon-transfer-in-liaoning-province-china
#9
Xian-Jin Zhu, Han-Qi Zhang, Tian-Hong Zhao, Jian-Dong Li, Hong Yin
Spatial and temporal variations are important points of focus in ecological research. Analysing their differences improves our understanding on the variations of ecological phenomena. Using data from the Liaoning Statistical Yearbook, we investigated the spatial and temporal variations of cropland carbon transfer (CCT), an important ecological phenomenon in quantifying the regional carbon budget, in particular, the influencing factors and difference. The results showed that, from 1992 to 2014, the average CCT in Liaoning province was 18...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021408/repeat-syphilis-has-a-different-immune-response-compared-with-initial-syphilis-an-analysis-of-biomarker-kinetics-in-two-cohorts
#10
Chris Kenyon, Achilleas Tsoumanis, Kara Osbak, Marjan Van Esbroeck, Eric Florence, Tania Crucitti, Luc Kesten
OBJECTIVE: We aimed to asses if there are differences in the clinical presentation and immune response of repeat as compared with initial syphilis. METHODS: Prospective study: we prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for a range of cytochemokines and rapid plasma reagin (RPR) at baseline pretreatment and 6 months following therapy. Retrospective study: we compared RPR assay response kinetics between initial and repeat syphilis in persons attending our HIV/STI clinic from 1993 to 2016...
October 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29020150/a-multicenter-study-evaluating-ceftriaxone-and-benzathine-penicillin-g-as-treatment-agents-for-early-syphilis-in-jiangsu-china
#11
Yuping Cao, Xiaohong Su, Qianqiu Wang, Huazhong Xue, Xiaofeng Zhu, Chuanfu Zhang, Juan Jiang, Shuzhen Qi, Xiangdong Gong, Xiaofang Zhu, Min Pan, Hong Ren, Wenlong Hu, Zhiping Wei, Meihua Tian, Weida Liu
Background: The aim of this study was to assess the efficacy of ceftriaxone and benzathine penicillin G (BPG) in nonpregnant, immunocompetent adults with early syphilis because there is a lack of clinical evidence supporting ceftriaxone as an alternative treatment for early syphilis without an human immunodeficiency virus coinfection. Methods: A randomized, open-label controlled study evaluating the efficacy of ceftriaxone and BPG was conducted in 4 hospitals in Jiangsu Province...
July 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28985653/response-surface-methodology-modeling-to-improve-degradation-of-chlorpyrifos-in-agriculture-runoff-using-tio2-solar-photocatalytic-in-a-raceway-pond-reactor
#12
Hoda Amiri, Ramin Nabizadeh, Susana Silva Martinez, Seyed Jamaleddin Shahtaheri, Kamyar Yaghmaeian, Alireza Badiei, Shahrokh Nazmara, Kazem Naddafi
This paper deals with the use of a raceway pond reactor (RPR) as an alternative photoreactor for solar photocatalytic applications. Raceway pond reactors are common low-cost reactors which can treat large volumes of water. The experiments were carried out with TiO2 in the agriculture effluent spiked with Chlorpyrifos (CPF) at circumneutral pH. The Response Surface Methodology (RSM) was used to find the optimum process parameters to maximize CPF oxidation from the mathematical model equations developed in this study using R software...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28948451/a-diagnostic-approach-to-stroke-in-young-adults
#13
REVIEW
Christopher A Stack, John W Cole
Optimal diagnosis and management of stroke in young adults benefit from a multidisciplinary team, including a vascular neurology specialist. In addition to the "standard" vascular risk factors including smoking, hypertension, diabetes, and hyperlipidemia, one needs to consider alternative etiologies including substance abuse, carotid/vertebral artery dissections, and rare genetic conditions among others. Once a young patient is determined to have had a stroke, the next question a clinician should ask is why did this patient have a stroke? A "heart to head" diagnostic approach is recommended...
September 25, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28944186/the-surgical-management-of-obstructive-hypertrophic-cardiomyopathy-the-rpr-procedure-resection-plication-release
#14
REVIEW
Daniel G Swistel, Mark V Sherrid
No abstract text is available yet for this article.
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28942420/unique-manifestations-and-risk-factors-of-jarisch-herxheimer-reaction-during-treatment-of-child-congenital-syphilis
#15
Caiying Wang, Shuxin He, Hongling Yang, Yuhuan Liu, Yang Zhao, Lin Pang
OBJECTIVES: The objective of this retrospective study was to summarise the clinical manifestations of, and to analyse the incidence and risk factors of, Jarisch-Herxheimer reaction (JHR) during the treatment of children with symptomatic congenital syphilis. METHODS: Clinical data of 60 children with clinically and laboratory diagnosed congenital syphilis, hospitalised in Beijing Ditan Hospital between January 2010 and November 2015, were collected and analysed. RESULTS: A total of 11 patients with congenital syphilis (11/60, 18...
September 23, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28938634/a-novel-predictive-model-using-routinely-clinical-parameters-to-predict-liver-fibrosis-in-patients-with-chronic-hepatitis-b
#16
Jian Wang, Xiaomin Yan, Yue Yang, Haiyan Chang, Bei Jia, Xiang-An Zhao, Guangmei Chen, Juan Xia, Yong Liu, Yuxin Chen, Guiyang Wang, Li Wang, Zhaoping Zhang, Weimao Ding, Rui Huang, Chao Wu
OBJECTIVES: Noninvasive models have been established for the assessment of liver fibrosis in patients with chronic hepatitis B(CHB). However, the predictive performance of these established models remains inconclusive. We aimed to develop a novel predictive model for liver fibrosis in CHB based on routinely clinical parameters. RESULTS: Platelets(PLT), the standard deviation of red blood cell distribution width(RDW-SD), alkaline phosphatase(ALP) and globulin were independent predictors of significant fibrosis by multivariable analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28893207/hepatitis-b-virus-and-hiv-co-infection-among-pregnant-women-in-rwanda
#17
Mwumvaneza Mutagoma, Helene Balisanga, Samuel S Malamba, Dieudonné Sebuhoro, Eric Remera, David J Riedel, Steve Kanters, Sabin Nsanzimana
BACKGROUND: Hepatitis B virus (HBV) affects people worldwide but the local burden especially in pregnant women and their new born babies is unknown. In Rwanda HIV-infected individuals who are also infected with HBV are supposed to be initiated on ART immediately. HBV is easily transmitted from mother to child during delivery. We sought to estimate the prevalence of chronic HBV infection among pregnant women attending ante-natal clinic (ANC) in Rwanda and to determine factors associated with HBV and HIV co-infection...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28878003/evaluation-of-the-lumipulse-g-tp-n-chemiluminescent-immunoassay-as-a-syphilis-screening-test
#18
Daniel A Ortiz, Michael J Loeffelholz
A syphilis diagnosis is often aided by the detection of treponemal and nontreponemal antibodies. Automated treponemal antibody detection systems enable high-volume clinical laboratories to perform syphilis screening at a faster pace with lower labor costs. The Lumipulse G TP-N chemiluminescent immunoassay is an automated system that qualitatively detects IgG and IgM antibodies against Treponema pallidum antigens in human serum and plasma. To assess performance characteristics and workflow efficiency, the Lumipulse G TP-N assay was compared to the Bioplex 2200 Syphilis IgG multiplex flow immunoassay...
November 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28876300/what-is-the-role-of-paired-rapid-plasma-reagin-testing-simultaneous-testing-of-acute-and-convalescent-samples-in-the-diagnosis-of-repeat-syphilis-and-the-follow-up-of-syphilis
#19
Chris R Kenyon, Kara Krista Osbak, Marjan Van Esbroek, Lutgarde Lynen, Tania Crucitti
BACKGROUND: Repeat syphilis is playing an increasing role in syphilis transmission in several populations. The assessment of repeat syphilis and response to treatment depends on accurately measuring intraindividual changes in non-treponemal tests. For a 0- to 6-month delta rapid plasma reagin (RPR) to be determined by routine individual RPR testing, samples are tested 6 months apart with differences in reagent batches, environmental conditions, and observers all leading to measurement errors...
July 20, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28868128/design-of-peptides-interfering-with-iron-dependent-regulator-ider-and-evaluation-of-mycobacterium-tuberculosis-growth-inhibition
#20
Himen Salimizand, Saeid Amel Jamehdar, Leila Babaei Nik, Hamid Sadeghian
OBJECTIVES: Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (Mtb), stayed a global health thread with high mortality rate. Since TB has a long-term treatment, it leads high risk of drug resistant development, and there is an urgent to find new drugs. The aim of this study was designing new inhibitors for a new drug target, iron dependent regulator, IdeR. MATERIALS AND METHODS: Based on the interaction most populated amino acids of IdeR to the related gene operators, 50 short peptides were modeled...
June 2017: Iranian Journal of Basic Medical Sciences
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