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https://www.readbyqxmd.com/read/28220718/the-big-imitator-strikes-again-a-case-report-of-neurosyphilis-in-a-patient-with-newly-diagnosed-hiv
#1
Sévérine de Bruijn, Chris Kenyon, Nicolas Léonard, Erika Vlieghe
BACKGROUND: Neurosyphilis is the result of an infection of the central nervous system caused by the spirochete Treponema pallidum. Its clinical presentation includes meningovascular syphilis, tabes dorsalis, and dementia paralytica, resulting in a wide range of symptoms such as psychosis, Parkinsonism, and depression. CASE REPORT: A 49-year-old male was admitted to a psychiatric hospital because of social withdrawal and self-neglect, indicative of a major depression...
February 21, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28196838/screening-for-asymptomatic-neurosyphilis-in-hiv-patients-after-treatment-of-early-syphilis-an-observational-study
#2
Andrew Tomkins, Shazaad Ahmad, Darren E Cousins, Caroline M Thng, Francisco Javier Vilar, Stephen P Higgins
OBJECTIVE: To determine the prevalence of asymptomatic neurosyphilis (ANS) in HIV-positive individuals after treatment of early syphilis with single-dose benzathine penicillin G (BPG) or oral antibiotic alternatives. METHODS: Patients at high risk of neurosyphilis (defined by serum rapid plasma reagin (RPR) titre ≥1:32 and/or peripheral blood CD4 lymphocyte count ≤350/μL) underwent lumbar puncture (LP) at a median time of 8.2 months post treatment. ANS was diagnosed by a reactive cerebrospinal fluid (CSF) RPR test or CSF white blood cells (WBC) >20/μL plus a reactive CSF Treponema pallidum particle agglutination (TPPA) ≥1:640...
February 14, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28130852/a-novel-noninvasive-algorithm-for-the-assessment-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b-virus-infection
#3
Ming-Yu Zhu, Xia Zou, Qiang Li, De-Min Yu, Zhi-Tao Yang, Dao Huang, Jie Chen, Qi-Ming Gong, Dong-Hua Zhang, Yan Zhang, Liang Chen, Pei-Zhan Chen, Xin-Xin Zhang
Several noninvasive blood biomarkers have been established for the assessment of liver fibrosis in patients with chronic hepatitis B virus (HBV) infection, but their clinical performance remains inconclusive. Here, we compared the diagnostic performance of these biomarkers and developed a novel algorithm for assessing liver fibrosis. Six hundred and sixteen chronic HBV-infected and treatment-naïve patients who underwent liver biopsy were enrolled and randomly divided into training (N = 410) and internal validation cohorts (N = 206)...
January 27, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28121915/moderate-exercise-increases-endotoxin-concentration-in-hypoxia-but-not-in-normoxia-a-controlled-clinical-trial
#4
RANDOMIZED CONTROLLED TRIAL
Paola Machado, Aline Caris, Samile Santos, Edgar Silva, Lila Oyama, Sergio Tufik, Ronaldo Santos
BACKGROUND: Hypoxia and high altitudes affect various organs, which impairs important physiological functions, such as a disruption of the intestinal barrier mediated by increased translocation of bacteria and increased circulating endotoxin levels. Physical exercise can alter endotoxin concentration in normoxia. The aim of this study is to evaluate the effects of moderate exercise on endotoxin concentration in normobaric hypoxia. METHODS: Nine healthy male volunteers exercised on a treadmill for 60 minutes at an intensity of 50% VO2peak in normoxic or hypoxic conditions (4200 m)...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072863/a-single-dose-oral-azithromycin-versus-intramuscular-benzathine-penicillin-for-the-treatment-of-yaws-a-randomized-non-inferiority-trial-in-ghana
#5
Cynthia Kwakye-Maclean, Nsiire Agana, John Gyapong, Priscilia Nortey, Yaw Adu-Sarkodie, Esther Aryee, Kingsley Asiedu, Roland Ballard, Fred Binka
BACKGROUND: Yaws is a treponemal infection that was almost eradicated fifty years ago; however, the disease has re-emerged in a number of countries including Ghana. A single-dose of intramuscular benzathine penicillin has been the mainstay of treatment for yaws. However, intramuscular injections are painful and pose safety and logistical constraints in the poor areas where yaws occurs. A single center randomized control trial (RCT) carried out in Papua New Guinea in 2012 demonstrated the efficacy of a single-dose of oral azithromycin for the treatment of yaws...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28048025/tu-d-201-09-is-the-ms-degree-still-a-viable-option-for-clinical-medical-physics-education-and-training
#6
B Loughery, J Burmeister
PURPOSE: Recent publications have questioned the value of the MS degree and its future in medical physics education. This study investigates the residency placement rate (RPR) for CAMPEP-accredited MS programs as a metric to evaluate this degree as judged by residency programs. METHODS: By CAMPEP Standard 2.10, accredited graduate programs must present placement data on their program webpage and update it annually. We used these data to calculate the RPR of 43 programs into CAMPEP-accredited residency programs over a five year period (2010-2014)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28018688/nigerian-female-with-skin-lesions-in-the-leg-and-face-herpetic-sycosis-folliculitis
#7
Dominique Dilorenzo, Naganna Channaveeraiah, Patricia Gilford, Bruce Deschere
Nongenital HSV 1 presents outside the mucus membrane. Our patient had unusual presentation that caused diagnostic dilemma. 30-year-old native Nigerian female coming with fiancée to the United States presented to our service one day after arrival through ER with a lesion on her right ankle. She was diagnosed with cellulitis, started on antibiotics, and admitted to hospital. She had fever of 39.1°C. Head and neck exam showed multiple sized lesions over tongue and palate and inner aspect of lower lip. Abdomen and genital exam was normal...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27998453/-clinical-features-of-neurosyphilis-with-optic-neuritis-as-an-initial-finding
#8
S S Cao, H Y Li, Q G Xu, S Y Tan, S H Wei
Objective: To study the characteristics of neurosyphilis with optic neuritis as an initial finding. Methods: Retrospective analysis of clinical data and laboratory testing results of 16 cases (27 eyes) with optic neuritis as an initial finding of neurosyphilis from October 2010 to March 2015 in General Hospital of People's Liberation Army was made. Results: Six-teen patients (12 males, 4 females) were collected, the median age of patients was 47 (range 33 to 65) years ,the mean age was (49.63±9.05) years. Treponema pallidum particle agglutination assay (TPPA) analysis was positive in all of the patients and rapid plasma reagin (RPR) test was positive in 14 patients (2 patients did not test)...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27992604/incidence-and-risk-factors-for-incident-syphilis-among-hiv-1-infected-men-who-have-sex-with-men-in-a-large-urban-hiv-clinic-in-tokyo-2008-2015
#9
Takeshi Nishijima, Katsuji Teruya, Satoshi Shibata, Yasuaki Yanagawa, Taiichiro Kobayashi, Daisuke Mizushima, Takahiro Aoki, Ei Kinai, Hirohisa Yazaki, Kunihisa Tsukada, Ikumi Genka, Yoshimi Kikuchi, Shinichi Oka, Hiroyuki Gatanaga
BACKGROUND: The epidemiology of incident syphilis infection among HIV-1-infected men who have sex with men (MSM) largely remains unknown. METHODS: The incidence and risk factors for incident syphilis (positive TPHA and RPR> = 1:8) among HIV-1-infected MSM who visited a large HIV clinic in Tokyo for the first time between 2008 and 2013 were determined, using clinical data and stored blood samples taken every three months for screening and determination of the date of incident syphilis...
2016: PloS One
https://www.readbyqxmd.com/read/27920885/cloning-and-expression-of-soluble-recombinant-hiv-1-crf35-protease-hp-thioredoxin-fusion-protein
#10
Asaad Azarnezhad, Zohreh Sharifi, Rahmatollah Seyedabadi, Arshad Hosseini, Behrooz Johari, Mahsa Sobhani Fard
BACKGROUND: As a drug target and an antigenic agent, HIV-1 protease (HIV-1 PR) is at the center of attention for designing anti-AIDS inhibitors and diagnostic tests. In previous studies, the production of the recombinant protease has been faced with several difficulties; therefore, the aims of this study were the easy production, purification of the soluble form of protease in E. coli and investigation of its immunoreactivity. METHODS: Protease coding region was isolated from the serum of an infected individual, amplified by RT-PCR and cloned into PTZ57R using TA-cloning...
October 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27898575/rate-of-decline-in-nontreponemal-antibody-titers-and-seroreversion-after-treatment-of-early-syphilis
#11
Arlene C Seña, Mark Wolff, Frieda Behets, David H Martin, Peter Leone, Carol Langley, Linda McNeil, Edward W Hook
BACKGROUND: Syphilis management is complex and demonstration of treatment response requires monitoring of nontreponemal antibody titers for a ≥ 4-fold decline and/or seroreversion to nonreactive titers. METHODS: We evaluated data from a multicenter clinical trial of syphilis treatment conducted from 2000 to 2009 involving human immunodeficiency virus (HIV)-negative patients 18 years or older with early syphilis. To assess the rate of titer decline and seroreversion after effective therapy, rapid plasma reagin (RPR) titers were analyzed at 1, 3, 6, 9, and 12 months among patients with an appropriate treatment response...
January 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27847752/screw-in-forces-during-instrumentation-by-various-file-systems
#12
Jung-Hong Ha, Sang Won Kwak, Sung-Kyo Kim, Hyeon-Cheol Kim
OBJECTIVES: The purpose of this study was to compare the maximum screw-in forces generated during the movement of various Nickel-Titanium (NiTi) file systems. MATERIALS AND METHODS: Forty simulated canals in resin blocks were randomly divided into 4 groups for the following instruments: Mtwo size 25/0.07 (MTW, VDW GmbH), Reciproc R25 (RPR, VDW GmbH), ProTaper Universal F2 (PTU, Dentsply Maillefer), and ProTaper Next X2 (PTN, Dentsply Maillefer, n = 10). All the artificial canals were prepared to obtain a standardized lumen by using ProTaper Universal F1...
November 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27843564/bleeding-events-and-maintenance-dose-of-prasugrel-bless-pilot-study
#13
Nazario Carrabba, Guido Parodi, Rossella Marcucci, Renato Valenti, Anna Maria Gori, Angela Migliorini, Vincenzo Comito, Benedetta Bellandi, Rosanna Abbate, Gian Franco Gensini, David Antoniucci
OBJECTIVE: To evaluate changes in residual platelet reactivity (RPR) over time, and bleeding and ischaemic events rate using 5 vs 10 mg maintenance dose (MD) regimens of prasugrel 1 month after acute coronary syndrome (ACS). BACKGROUND: The optimal level of RPR with prasugrel may change over time after an ACS. METHODS: After 60 mg loading dose of prasugrel (T0) followed by 10 mg/day for 1 month, patients were randomised to receive prasugrel 10 mg/day (n=95, group A) or 5 mg/day MD (n=98, group B) up to 1 year...
2016: Open Heart
https://www.readbyqxmd.com/read/27822608/expression-of-anoctamins-in-retinal-pigment-epithelium-rpe
#14
Rainer Schreiber, Karl Kunzelmann
The anoctamin (ANO, TMEM16) family of Ca(2+)-activated Cl(-) channels consists of ten members with different cellular functions (ANO1-10). ANO1 is a Ca(2+)-activated Cl(-) channel in secretory epithelial cells of exocrine pancreas, salivary glands, or enterocytes. Expression of ANO1 also promotes cell proliferation and migration of tumor cells. ANO6 is essential for Ca(2+)-dependent scrambling of membrane phospholipids in platelets, red blood cells, and lymphocytes. ANO10 modulates Ca(2+) signals in macrophages and has a role in cerebellar ataxia and other neurological disorders...
November 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27787876/effect-of-a-long-term-physical-activity-intervention-on-resting-pulse-rate-in-older-persons-results-from-the-lifestyle-interventions-and-independence-for-elders-study
#15
Bríain Ó Hartaigh, Laura C Lovato, Marco Pahor, Thomas W Buford, John A Dodson, Daniel E Forman, Matthew P Buman, Jamehl L Demons, Adam J Santanasto, Christine Liu, Michael E Miller, Mary McGrae McDermott, Thomas M Gill
OBJECTIVES: To assess the utility of a long-term physical activity (PA) intervention for reducing resting pulse rate (RPR) in older persons. DESIGN: Community. SETTING: Lifestyle Interventions and Independence for Elders Study. PARTICIPANTS: Individuals aged 70 to 89 (N = 1,635, 67.2% women) were randomized to a moderate-intensity PA intervention (n = 818) or a health education-based successful aging (SA) intervention (n = 817)...
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27773873/performance-characteristics-of-the-reverse-syphilis-screening-algorithm-in-a-population-with-a-moderately-high-prevalence-of-syphilis
#16
Angela R Rourk, Frederick S Nolte, Christine M Litwin
OBJECTIVES: With the recent introduction of automated treponemal tests, a new reverse syphilis algorithm has been proposed and now used by many clinical laboratories. We analyzed the impact of instituting the reverse screening syphilis algorithm in a laboratory that serves a geographic area with a moderately high prevalence of syphilis infection. METHODS: Serum samples sent for syphilis testing were tested using a treponemal enzyme immunoassay (EIA) as the screening assay...
October 22, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27751728/macrophage-migration-inhibitory-factor-as-a-novel-cerebrospinal-fluid-marker-for-neurosyphilis-among-hiv-negative-patients
#17
Li-Rong Lin, Dan-Hong Lin, Man-Li Tong, Li-Li Liu, Jin-Yi Fan, Xiao-Zhen Zhu, Kun Gao, Mei-Jun Chen, Wei-Hong Zheng, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Jian-Jun Niu, Tian-Ci Yang
BACKGROUND: Neurosyphilis (NS) is difficult to diagnose, especially in syphilis patients with negative cerebrospinal fluid (CSF) rapid plasma reagin (RPR) or Venereal Disease Research Laboratory (VDRL) tests. METHODS: We conducted a cross-sectional study and an analysis of macrophage migration inhibitory factor (MIF) in syphilitic patients to identify a novel marker for the diagnosis of NS, with a focus on probable NS (NS with negative VDRL/RPR tests). For this purpose, CSF and serum MIF concentrations were determined in 43 NS and 43 syphilis/non-NS (N-NS) patients at the Zhongshan Hospital of the Medical College of Xiamen University from July 2014 to June 2015...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27725694/three-dimensional-reconstruction-of-single-cell-chromosome-structure-using-recurrence-plots
#18
Yoshito Hirata, Arisa Oda, Kunihiro Ohta, Kazuyuki Aihara
Single-cell analysis of the three-dimensional (3D) chromosome structure can reveal cell-to-cell variability in genome activities. Here, we propose to apply recurrence plots, a mathematical method of nonlinear time series analysis, to reconstruct the 3D chromosome structure of a single cell based on information of chromosomal contacts from genome-wide chromosome conformation capture (Hi-C) data. This recurrence plot-based reconstruction (RPR) method enables rapid reconstruction of a unique structure in single cells, even from incomplete Hi-C information...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27723157/improving-the-screening-of-blood-donors-with-syphilis-rapid-diagnostic-test-rdt-and-rapid-plasma-reagin-rpr-in-low-and-middle-income-countries-lmic
#19
F Sarkodie, O Hassall, E Owusu-Dabo, S Owusu-Ofori, I Bates, I C Bygbjerg, A Owusu-Ofori, L H Harritshøj, H Ullum
BACKGROUND: Syphilis testing conventionally relies on a combination of non-treponemal and treponemal tests. The primary objective of this study was to describe the positive predictive value (PPV) of a screening algorithm in a combination of a treponemal rapid diagnostic test (RDT) and rapid plasma reagin (RPR) test at Komfo Anokye Teaching Hospital (KATH), Ghana. MATERIALS AND METHODS: From February 2014 to January 2015, 5 mL of venous blood samples were taken from 16 016 blood donors and tested with a treponemal RDT; 5 mL of venous blood was taken from 526 consenting initial syphilis sero-reactive blood donors...
October 10, 2016: Transfusion Medicine
https://www.readbyqxmd.com/read/27709684/diagnostic-validity-of-hematologic-parameters-in-evaluation-of-massive-pulmonary-embolism
#20
Hale Ates, Ihsan Ates, Harun Kundi, Fatma Meric Yilmaz
BACKGROUND: The aim of this study was to determine the hematologic parameter with the highest diagnostic differentiation in the identification of massive acute pulmonary embolism (APE). METHODS: A retrospective study was performed on patients diagnosing with APE between June 2014 and June 2016. All radiological and laboratory parameters of patients were scanned through the electronic information management system of the hospital. PLR was obtained from the ratio of platelet count to lymphocyte count, NLR was obtained from the ratio of neutrophil count to lymphocyte count, WMR was obtained from white blood cell in mean platelet volume ratio, MPR was obtained from the ratio of mean platelet volume to platelet count, and RPR was obtained from the ratio of red distribution width to platelet count...
October 6, 2016: Journal of Clinical Laboratory Analysis
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