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https://www.readbyqxmd.com/read/29251384/aspartate-transaminase-to-platelet-ratio-index-and-gamma-glutamyl-transpeptidase-to-platelet-ratio-outweigh-fibrosis-index-based-on-four-factors-and-red-cell-distribution-width-platelet-ratio-in-diagnosing-liver-fibrosis-and-inflammation-in-chronic-hepatitis
#1
Xiaojuan Wu, Bei Cai, Zhenzhen Su, Yamei Li, Jin Xu, Rong Deng, Lanlan Wang
BACKGROUND: The benefits of using serum markers to diagnose stages of liver disease in chronic hepatitis B (CHB) patients are controversial. We conducted a study to compare the clinical significance of four markers in evaluating liver inflammation and fibrosis in CHB patients. METHODS: A total of 323 treatment-naive CHB patients who received a liver biopsy and routine laboratory testing were enrolled in our study. We used the Scheuer scoring system as a pathological standard for diagnosing liver inflammation and fibrosis...
December 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29223963/field-evaluation-of-two-point-of-care-tests-for-syphilis-among-men-who-have-sex-with-men-verona-italy
#2
Antonella Zorzi, Maddalena Cordioli, Lorenzo Gios, Paola Del Bravo, Igor Toskin, Rosanna W Peeling, Karel Blondeel, Giuseppe Cornaglia, James Kiarie, Ronald Ballard, Massimo Mirandola
OBJECTIVES: The incidence of HIV and syphilis among men who have sex with men (MSM) in Europe has recently increased. Rapid point-of-care tests (POCTs) for syphilis can improve access to screening. The purpose of this study was to evaluate the performance of two syphilis POCTs compared with laboratory tests among MSM. METHODS: The study was undertaken in Verona, Italy. Asymptomatic MSM, potentially exposed to syphilis, were enrolled prospectively. The POCTs evaluated were SD Bioline Syphilis 3...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29200971/vwf-adamts13-is-associated-with-on-aspirin-residual-platelet-reactivity-and-clinical-outcome-in-patients-with-stable-coronary-artery-disease
#3
Ellen M K Warlo, Alf-Åge R Pettersen, Harald Arnesen, Ingebjørg Seljeflot
Background: The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated levels of von Willebrand factor (vWF). ADAMTS13 is a metalloprotease cleaving ultra large vWF multimers into less active fragments.Our aim was to investigate whether ADAMTS13 and vWF/ADAMTS13 ratio were associated with high RPR, and further with clinical endpoints after 2 years...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/29200767/serologic-response-to-treatment-in-human-immunodeficiency-virus-negative-syphilis-patients-using-automated-serological-tests-proposals-for-new-guidelines
#4
Jung-In Kim, Ji-Hye Park, Ju-Yeon Choi, Ga-Young Lee, Won-Serk Kim
Background: Automated analyzer-based nontreponemal serological tests for syphilis (STS) have been used for several decades. Objective: In this study, we evaluated serological responses to treatment and proposed clinical guidelines for automated STS. Methods: This retrospective cohort study analyzed human immunodeficiency virus-negative syphilis patients who were diagnosed with automated rapid plasma reagin (auto RPR) tests as a nontreponemal STS, and who also received the fluorescent treponemal antibody-absorption test as a confirmatory test...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29196305/multiple-simultaneous-infections-in-a-patient-with-well-controlled-hiv-when-occam-s-razor-fails
#5
Miranda Sherley, Sarah Jane Martin
Multiple concurrent infectious processes have previously been reported in the context of advanced HIV with significant immunosuppression. Here we report a case of multiple infections in a 56-year-old man with well-controlled HIV diagnosed 5 years earlier. Soon after returning to Australia following 12 years living in Thailand, he became unwell with fevers, night sweats, arthralgia and myalgia. There were no localising symptoms and examination was unremarkable. Investigations revealed positive syphilis (Treponema pallidum) serology with an RPR of 16, a positive urine culture (Klebsiella pneumoniae), a pulmonary nodule, a liver abscess and colitis (Entamoeba histolytica)...
December 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29184321/rapid-response-to-syphilis-outbreak-among-female-sex-workers
#6
Shaily B Surti, J K Kosambiya, Neeta Khokhar, Mohamedanas Mohamedfaruk Patni, Alpesh H Gohil, Zeel N Kamdar, Dipak Umrigar, Ragini Verma, Summaiya Mulla
Background: Outbreak of syphilis, i.e., 16 cases of rapid plasma reagin (RPR) reactive cases of syphilis was reported in Community Based Organization (CBO) Sahyog of Surat, India, from April to August 2014. The aim of the study was to find risk factors and take immediate actions to prevent spread. Materials and Methods: Outbreak investigation of 16 Female Sex Workers of CBO Sahyog in Surat who were found Rapid Plasma Reagin (RPR) and Treponema Pallidum Hemagglutination Assay (TPHA) positive from April to August 2014; was carried out...
October 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29138654/syphilis-and-hiv-infections-among-pregnant-women-attending-antenatal-clinics-in-republic-of-congo
#7
Roch Fabien Niama, Nadia Claricelle Loukabou Bongolo, Edith Sophie Bayonne Kombo, Ruth Yengo, Pembe Issamou Mayengue, Etoka-Beka Mandingha Kosso, Igor Louzolo, Lucette Macosso, Ghislain Dzeret, Angélie Serge Patrick Dzabatou Babeaux, Marie-Francke Puruehnce, Henri Joseph Parra
Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. Methods: A study was conducted in 44 selected ANCs from 12 departments (5 urban and 7 rural). Pregnant women who accepted to participate in the study, attending selected sentinel ANCs sites for the first time between September and December 2011 were enrolled...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29136161/trends-and-predictors-of-syphilis-prevalence-in-the-general-population-global-pooled-analyses-of-1103-prevalence-measures-including-136-million-syphilis-tests
#8
Alex Smolak, Jane Rowley, Nico Nagelkerke, Nicholas J Kassebaum, R Matthew Chico, Eline L Korenromp, Laith J Abu-Raddad
Background: This study assessed levels, trends, and associations of observed syphilis prevalence in the general adult population using global pooled analyses. Methods: A standardized database of syphilis prevalence was compiled by pooling systematically-gathered data. Random-effects meta-analyses and meta-regressions were conducted using data from 1990-2016 to estimate pooled measures and assess predictors and trends. Countries were classified by World Health Organization regions...
November 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29133821/incidence-of-asymptomatic-neurosyphilis-in-serofast-chinese-syphilis-patients
#9
Sheng Nan Cai, Jing Long, Chen Chen, Gang Wan, Wen Hui Lun
More new diagnosed syphilis cases were reported in china, the incidence and relevant factors of asymptomatic neurosyphilis (ANS) in serofast syphilis patients were unclear. Clinical and laboratory data of 402 Human Immunodeficiency Virus (HIV) negative, serofast syphilis patients, who underwent lumbar puncture at the Peking University Ditan Teaching Hospital between September 2008 and August 2016, were collected. Incidence of ANS was verified and the relevant factors were further analyzed. According to the ANS criteria, 139 (34...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29107589/metamizole-and-platelet-inhibition-by-aspirin-following-on-pump-coronary-artery-bypass-grafting
#10
Mirosław Wilczyński, Maciej T Wybraniec, Marek Sanak, Joanna Góral, Katarzyna Mizia-Stec
OBJECTIVE: The purpose of the study was to evaluate the impact of intravenous metamizole on platelet inhibition by aspirin in patients with coronary artery disease early after on-pump coronary artery bypass grafting (CABG). DESIGN: Prospective, single-blind, randomized trial. SETTING: Tertiary referal hospital. PARTICIPANTS: The study comprised 43 patients with multivessel coronary artery disease undergoing CABG. INTERVENTIONS: Patients were randomized to postoperative intravenous metamizole ± opioids (study group; n = 23) or opioids alone (control group; n = 20)...
June 7, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29076438/stevens-johnson-syndrome-versus-jarisch-herxheimer-reaction-in-an-hiv-positive-patient-with-secondary-syphilis
#11
Sarah Micozzi, Patricia Rojas Perez-Ezquerra, Cristina Morales-Cabeza, Cristina Diez, Manuel De Barrio
BACKGROUND: HIV positive patients can suffer many complications due to infectious diseases. A severe reaction to some of the drugs involved in the treatment can overlap with the symptoms of infections, making diagnosis very difficult. We present the case of an HIV positive 28-year-old-man, , with secondary syphilis, who developed a Stevens Johnson Syndrome (SJS) caused by one of the many drugs he was receiving. The SJS overlapped with a possible Jarisch Herxheimer Reaction, which complicated diagnosis of the skin reaction...
October 26, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29057939/prognostic-values-of-red-blood-cell-distribution-width-platelet-count-and-red-cell-distribution-width-to-platelet-ratio-for-severe-burn-injury
#12
Le Qiu, Chen Chen, Shi-Ji Li, Chao Wang, Feng Guo, April Peszel, Sheng Liu, Fei Wang, Ye-Xiang Sun, Yong-Jie Wang, Xu-Lin Chen
Red blood cell distribution width (RDW), platelet count (PLT), and a RDW-to-PLT ratio (RPR) have been associated with inflammatory activity and adverse outcomes in many diseases. This study has aimed to investigate the association between these indicators and the mortality rate of severe burn patients. From 2008 to 2014, 610 cases of severe burn patients from two burn centers in eastern China were enrolled in this study. Eighty-eight patients died within 90 days after admission. The RDW, PLT, and RPR were studied through Cox regression analysis on the 3rd and 7th day...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29053397/combined-intravitreal-and-systemic-antibiotic-therapy-in-a-patient-with-syphilitic-uveitis
#13
Arjun B Sood, William A Pearce, Kimberly A Workowski, James Lockwood, Steven Yeh
PURPOSE: To report the novel use of combined intravitreal and systemic antibiotic therapy in a patient with syphilitic panuveitis and discuss the management of ocular syphilis. METHODS: Case report Results: A 45-year old heterosexual male with human immunodeficiency virus (HIV) presented with 1 month of blurry vision in both eyes. Clinical examination revealed a bilateral panuveitis. The patient denied history of genital lesions or rash, but did complain of difficulty hearing bilaterally...
October 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29046410/correlation-of-treponemal-immunoassay-signal-strength-values-with-reactivity-of-confirmatory-treponemal-testing
#14
Yetunde F Fakile, Heather Jost, Karen W Hoover, Kathleen J Gustafson, Susan M Novak-Weekley, Jeff M Schapiro, Anthony Tran, Joan M Chow, Ina U Park
Automated treponemal immunoassays are used for syphilis screening with the reverse sequence algorithm; discordant results (e.g., enzyme immunoassay [EIA]-reactive, reactive plasma reagin [RPR]-non-reactive) are resolved with a second treponemal test. We conducted a study to determine automated immunoassay signal strength values consistently correlating with reactive confirmatory treponemal testing.We conducted a cross-sectional analysis of four automated immunoassays: BioPlex 2200 microbead immunoassay (MBIA), LIAISON chemiluminesence immunoassay (CIA), ADVIA-Centaur CIA, and TrepSure EIA, and three manual assays: Treponema Pallidum Particle Agglutination (TP-PA), Fluorescent Treponemal Antibody-Absorption (FTA-ABS) test, INNO-LIA line immunoassay...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29026177/divergent-drivers-of-the-spatial-and-temporal-variations-of-cropland-carbon-transfer-in-liaoning-province-china
#15
Xian-Jin Zhu, Han-Qi Zhang, Tian-Hong Zhao, Jian-Dong Li, Hong Yin
Spatial and temporal variations are important points of focus in ecological research. Analysing their differences improves our understanding on the variations of ecological phenomena. Using data from the Liaoning Statistical Yearbook, we investigated the spatial and temporal variations of cropland carbon transfer (CCT), an important ecological phenomenon in quantifying the regional carbon budget, in particular, the influencing factors and difference. The results showed that, from 1992 to 2014, the average CCT in Liaoning province was 18...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021408/repeat-syphilis-has-a-different-immune-response-compared-with-initial-syphilis-an-analysis-of-biomarker-kinetics-in-two-cohorts
#16
Chris Kenyon, Achilleas Tsoumanis, Kara Osbak, Marjan Van Esbroeck, Eric Florence, Tania Crucitti, Luc Kesten
OBJECTIVE: We aimed to asses if there are differences in the clinical presentation and immune response of repeat as compared with initial syphilis. METHODS: Prospective study: we prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for a range of cytochemokines and rapid plasma reagin (RPR) at baseline pretreatment and 6 months following therapy. Retrospective study: we compared RPR assay response kinetics between initial and repeat syphilis in persons attending our HIV/STI clinic from 1993 to 2016...
October 11, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29020150/a-multicenter-study-evaluating-ceftriaxone-and-benzathine-penicillin-g-as-treatment-agents-for-early-syphilis-in-jiangsu-china
#17
Yuping Cao, Xiaohong Su, Qianqiu Wang, Huazhong Xue, Xiaofeng Zhu, Chuanfu Zhang, Juan Jiang, Shuzhen Qi, Xiangdong Gong, Xiaofang Zhu, Min Pan, Hong Ren, Wenlong Hu, Zhiping Wei, Meihua Tian, Weida Liu
Background: The aim of this study was to assess the efficacy of ceftriaxone and benzathine penicillin G (BPG) in nonpregnant, immunocompetent adults with early syphilis because there is a lack of clinical evidence supporting ceftriaxone as an alternative treatment for early syphilis without an human immunodeficiency virus coinfection. Methods: A randomized, open-label controlled study evaluating the efficacy of ceftriaxone and BPG was conducted in 4 hospitals in Jiangsu Province...
October 30, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28985653/response-surface-methodology-modeling-to-improve-degradation-of-chlorpyrifos-in-agriculture-runoff-using-tio2-solar-photocatalytic-in-a-raceway-pond-reactor
#18
Hoda Amiri, Ramin Nabizadeh, Susana Silva Martinez, Seyed Jamaleddin Shahtaheri, Kamyar Yaghmaeian, Alireza Badiei, Shahrokh Nazmara, Kazem Naddafi
This paper deals with the use of a raceway pond reactor (RPR) as an alternative photoreactor for solar photocatalytic applications. Raceway pond reactors are common low-cost reactors which can treat large volumes of water. The experiments were carried out with TiO2 in the agriculture effluent spiked with Chlorpyrifos (CPF) at circumneutral pH. The Response Surface Methodology (RSM) was used to find the optimum process parameters to maximize CPF oxidation from the mathematical model equations developed in this study using R software...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28948451/a-diagnostic-approach-to-stroke-in-young-adults
#19
REVIEW
Christopher A Stack, John W Cole
Optimal diagnosis and management of stroke in young adults benefit from a multidisciplinary team, including a vascular neurology specialist. In addition to the "standard" vascular risk factors including smoking, hypertension, diabetes, and hyperlipidemia, one needs to consider alternative etiologies including substance abuse, carotid/vertebral artery dissections, and rare genetic conditions among others. Once a young patient is determined to have had a stroke, the next question a clinician should ask is why did this patient have a stroke? A "heart to head" diagnostic approach is recommended...
September 25, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28944186/the-surgical-management-of-obstructive-hypertrophic-cardiomyopathy-the-rpr-procedure-resection-plication-release
#20
REVIEW
Daniel G Swistel, Mark V Sherrid
No abstract text is available yet for this article.
July 2017: Annals of Cardiothoracic Surgery
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