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Gladys Pinilla, Lesly Campos, Andrea Durán, Jeannette Navarrete, Liliana Muñoz
Introducción. La sífilis es una enfermedad producida por Treponema pallidum subespecie pallidum cuya incidencia mundial es de 12 millones de casos por año, aproximadamente; de estos, más de dos millones se presentan en mujeres gestantes, siendo la sífilis congénita la complicación más grave de esta infección en el embarazo.Objetivo. Detectar la presencia de T. pallidum subespecie pallidum en muestras clínicas para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa (PCR) anidada y determinar su concordancia con las pruebas serológicas...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
Arjun B Sood, William A Pearce, Kimberly A Workowski, James Lockwood, Steven Yeh
PURPOSE: To report the novel use of combined intravitreal and systemic antibiotic therapy in a patient with syphilitic panuveitis and discuss the management of ocular syphilis. METHODS: Case report Results: A 45-year old heterosexual male with human immunodeficiency virus (HIV) presented with 1 month of blurry vision in both eyes. Clinical examination revealed a bilateral panuveitis. The patient denied history of genital lesions or rash, but did complain of difficulty hearing bilaterally...
October 20, 2017: Ocular Immunology and Inflammation
P S Wozniak, J B Cantey, F Zeray, N K Leos, J S Sheffield, G D Wendel, P J Sánchez
OBJECTIVE: Infants whose mothers had syphilis during pregnancy were studied to determine how often exposed newborns with normal physical examinations and nonreactive nontreponemal serologic tests had abnormal laboratory or radiographic studies. STUDY DESIGN: Retrospective analysis of prospectively collected data from infants born to mothers with syphilis and had a normal examination and a nonreactive nontreponemal test. Some infants had IgM immunoblotting, PCR testing or rabbit infectivity testing (RIT) performed...
October 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
Thuy T Trinh, Mary L Kamb, Minh Luu, D Cal Ham, Freddy Perez
OBJECTIVE: To present the findings of the Pan American Health Organization's 2014 survey on syphilis testing policies and practices in the Americas. METHODS: Representatives of national/regional reference and large, lower-level laboratories from 35 member states were invited to participate. A semi-structured, electronically administered questionnaire collected data on syphilis tests, algorithms, equipment/commodities, challenges faced and basic quality assurance (QA) strategies employed (i...
September 2017: Tropical Medicine & International Health: TM & IH
M Walker, R Wisler, J Simmons, A Johnson
INTRODUCTION: Neurosyphilis is an infection of the central nervous system by Treponema pallidum, which can occur after the initial syphilis infection. Although commonly associated with late stage disease, patients with early neurosyphilis may present with acute syphilitic meningitis, meningovascular syphilis, or uveitis. CASE: A 28 year old man with a past medical history of HIV (CD4 364);, and recent diagnosis of uveitis presented to the Emergency Department with a positive RPR result...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
Li-Rong Lin, Dan-Hong Lin, Man-Li Tong, Li-Li Liu, Jin-Yi Fan, Xiao-Zhen Zhu, Kun Gao, Mei-Jun Chen, Wei-Hong Zheng, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Jian-Jun Niu, Tian-Ci Yang
BACKGROUND: Neurosyphilis (NS) is difficult to diagnose, especially in syphilis patients with negative cerebrospinal fluid (CSF) rapid plasma reagin (RPR) or Venereal Disease Research Laboratory (VDRL) tests. METHODS: We conducted a cross-sectional study and an analysis of macrophage migration inhibitory factor (MIF) in syphilitic patients to identify a novel marker for the diagnosis of NS, with a focus on probable NS (NS with negative VDRL/RPR tests). For this purpose, CSF and serum MIF concentrations were determined in 43 NS and 43 syphilis/non-NS (N-NS) patients at the Zhongshan Hospital of the Medical College of Xiamen University from July 2014 to June 2015...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Emine Ünal, Müzeyyen Gönül, Seray Çakmak, Ayşegül Yalçınkaya Iyidal, Arzu Kılıç, Ülker Gül, Pinar Doner
INTRODUCTION: Human papillomavirus (HPV) is one of the most common causes of sexually transmitted diseases (STD). The incidence of condyloma acuminata (CA) has increased in recent years. AIM: To determine demographical features and serological test results of STD in patients with CA. MATERIAL AND METHODS: A cross-sectional survey was conducted on 94 patients presenting to a dermatology clinic in Ankara, Middle Anatolia, Turkey. Dermatological examinations were made and the patients completed a questionnaire which consisted of questions about their marital status, partners and condom use...
August 2015: Postȩpy Dermatologii i Alergologii
Sun Young Lee, Vincent Cheng, Damien Rodger, Narsing Rao
BACKGROUND: Ocular syphilis is reemerging as an important cause of uveitis in the new era of common co-infection with HIV. This study will reveal the clinical and laboratory characteristics in the group of individuals co-infected with ocular syphilis and HIV compared with HIV-negative individuals. In this retrospective observational case series, medical records of patients diagnosed with ocular syphilis with serologic support from 2008 to 2014 were reviewed. Ocular and systemic manifestation and laboratory profiles were reviewed...
December 2015: Journal of Ophthalmic Inflammation and Infection
Sufiyan I Shaikh, Jyotirmay Biswas, Pukhraj Rishi
BACKGROUND: Scleritis may be the initial or only presenting feature of systemic, autoimmune, or infectious disorders. Corticosteroids are the mainstay of treatment for immune-mediated scleritis. However, steroids could prove detrimental when used to treat infectious scleritis. Hence, infectious causes of scleritis should be ruled out. FINDINGS: A 47-year-old male from central India presented with swelling, pain, and redness in the left eye since 2 months. The patient was diagnosed elsewhere as having an extraocular extension of intraocular tumor and advised radiation brachytherapy for the same...
2015: Journal of Ophthalmic Inflammation and Infection
Nobuyasu Yukimasa, Keisuke Miura, Yukiko Miyagawa, Kunihiko Fukuchi
BACKGROUND: Automated nontreponemal and treponemal test reagents based on the latex agglutination method (immunoticles auto3 RPR: ITA3RPR and immunoticles auto3 TP: ITA3TP) have been developed to improve the issues of conventional manual methods such as their subjectivity, a massive amount of assays, and so on. We evaluated these reagents in regards to their performance, reactivity to antibody isotype, and their clinical significance. METHODS: ITA3RPR and ITA3TP were measured using a clinical chemistry analyzer...
January 2015: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Vineet Punia, Appaji Rayi, Adithya Sivaraju
Introduction. Syphilis incidence has increased in the US in the last decade. Jarisch-Herxheimer reaction (JHR) is a well-documented adverse effect of penicillin treatment in syphilis. Stroke has not been reported as part of its phenomenology. Case Report. A 57-year-old man presented with worsening memory. His minimental status examination score was 14/30. Serum RPR test was positive and VDRL test in the CSF was reactive. Within six hours of first dose of IV crystalline penicillin G, he was found to have hemineglect and difficulty moving the left leg...
2014: Case Reports in Neurological Medicine
Asim K Bag, Jake J Davenport, James R Hackney, Rasmoni Roy, Hassan M Fathallah-Shaykh
History A previously healthy 23-year-old white man presented to the emergency department of our hospital with a 2-month history of dysarthria, progressively worsening vertigo, and difficulty walking. A diagnosis of retinitis pigementosa was made in this patient's childhood. He did not have any history of congenital syphilis. He did not have a history of nausea or vomiting, fever, weight loss, headache, photophobia, seizure, extremity weakness, or sensory disturbance. Physical examination revealed dysarthria, dysmetria, and ataxia...
December 2014: Radiology
Sangeeta Pahuja, Santosh Kumar Gupta, Mukta Pujani, Manjula Jain
BACKGROUND: The aim of the present study was to determine the prevalence of syphilis infection by Treponema pallidum hemagglutination assay (TPHA) among blood donors in Delhi and to study their correlation with other markers of transfusion transmitted infections such as hepatitis C virus (HCV), human immunodeficiency virus (HIV) and hepatitis B surface antigen (HBsAg) so as to establish the utility of TPHA over and above venereal diseases research laboratory test (VDRL), not only as a marker for testing T...
July 2014: Asian Journal of Transfusion Science
Ki-Ho Park, Mi Suk Lee, Il Ki Hong, Ji-Youn Sung, Sang-Ho Choi, Sang Ok Park, Myung Jin Shin, Hye Won Chung, Sang Hoon Lee
Bone involvement is an unusual manifestation of secondary syphilis, but little information is available in the English-language literature. We carried out a systematic review of the English-language literature from 1964 to 2013, describing cases of secondary syphilis with bone involvement. We also describe a case of secondary syphilis with multiple osteolytic lesions, mimicking metastatic cancer or myeloma, which was included in an analysis of 37 eligible cases of secondary syphilis with bone involvement. Of these 37 patients, 28 (76%) patients were male, and the median age was 32 years (range, 12-64 years)...
September 2014: Sexually Transmitted Diseases
M Bala, V Singh, S Muralidhar, V Ramesh
In India, many state reference centres for sexually transmitted infections perform only a single screening assay for syphilis diagnosis. In this study, Treponema pallidum haemagglutination (TPHA) was performed on 1115 Venereal Disease Research Laboratory (VDRL)/rapid plasma regain (RPR) non-reactive and 107 reactive sera out of 10,489 tested by VDRL/RPR according to the National AIDS Control Organisation syphilis testing protocol. A total of 47 Specimens reactive in TPHA and non-reactive with VDRL test were subjected to fluorescent treponemal antibody absorption and enzyme-immunoassay...
July 2013: Indian Journal of Medical Microbiology
Smilja Kalenić, Ana Budimir
Organ/tissue/cell transplantation carries the risk of infection transfer from donor to recipient. Consecutive infections can be severe, lethal, and proceed to chronic condition without possibility of treating, treatable with known antimicrobial drugs. The possible consequences and infection development should be taken in consideration on planning the procedure. The risk of infectious disease transmission is estimated from patient history, evaluation of clinical documentation and microbiological test results...
December 2007: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
V Kotnik, K Jordan, S Stopinsek, S Simcic, M Potocnik
BACKGROUND: Laboratory detection of intrathecal synthesis of specific antitreponemal antibodies remains a challenge. Traditional syphilis serology is unable to provide a satisfactory result; therefore, several other diagnostic procedures were used to demonstrate central nervous system (CNS) involvement in this disease. The introduction of molecular methods makes today's laboratory testing easier. OBJECTIVE: Our study used a new commercially available test, the INNO-LIA Syphilis Score, intended for use on serum samples, to detect specific antitreponemal antibodies in the cerebrospinal fluid (CSF) of patients with the tertiary stage of syphilis...
December 2007: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
A Luger
The demonstration of Treponema pallidum in early specimens is still the most important procedure for definite diagnosis of the disease. Nonspecific lipoidal antigen tests, as well as assays using T. pallidum antigen, are used for the detection of antibodies in sera. The techniques, the interpretation of the results, the onset and limits of reactivity, as well as the sources of error of the VDRL (RPR), FTA-ABS, TPHA (MHA-TP, AMHA-TP), IgM FTA-ABS, I9S IgM-FTA-ABS, and IgM-SPHA tests are described. The presence of 19S IgM antibodies against T...
1981: Bulletin of the World Health Organization
M Guttenplan, R A Hendrix
The diagnosis and management of patients with suspected treponemal infection of the temporal bone pose some challenges. The following points deserve emphasis: 1) the MHA-TP or FTA-Abs is recommended over the reagin serologic tests (VDRL, RPR); 2) one should regard this process as an attempt to define a subgroup of patients with sensorineural hearing loss who will benefit from a combination of antibiotics and steroid therapy rather than explicitly diagnosing infection of the temporal bone. The response rate to therapy is limited; but, otosyphilis, as one of the few treatable causes of sensorineural hearing loss, must be suspected in the differential diagnosis of a wide range of otologic patients...
1989: Transactions—Pennsylvania Academy of Ophthalmology and Otolaryngology
H E Menke, J Veldkamp, E A Brunings, P L Niemel, A Notowicz, E Stolz
Results of the Veneral Disease Research Laboratory (VDRL), rapid plasma reagin (RPR), Treponema pallidum haemagglutination (TPHA), T. pallidum immobilisation (TPI), and fluorescent treponemal antibody absorption (FTA-ABS) tests on sera of 661 children from a region where yaws is hypoendemic are compared. For 107 (16.2%) out of 661 sera the FTA-ABS test was the only one showing reactivity; in these instances the test was weakly reactive (intensity of fluorescence scored as +) and the children had no history and no signs or symptoms of treponemal disease...
April 1979: British Journal of Venereal Diseases
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