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Treponema pallidum

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https://www.readbyqxmd.com/read/29788937/seroprevalence-of-transfusion-transmissible-infections-hbv-hcv-syphilis-and-hiv-among-prospective-blood-donors-in-a-tertiary-health-care-facility-in-calabar-nigeria-an-eleven-years-evaluation
#1
Henshaw Uchechi Okoroiwu, Ifeyinwa Maryann Okafor, Enosakhare Aiyudubie Asemota, Dorathy Chioma Okpokam
BACKGROUND: Provision of constant and safe blood has been a public health challenge in Sub-Saharan Africa with high prevalence of transfusion-transmissible infections (TTIs). This study was aimed at determining the trend and seroprevalence of HBV, HCV, syphilis and HIV across the years within study among prospective blood donors at blood bank in University of Calabar Teaching Hospital (UCTH), Calabar, Nigeria. METHODS: A retrospective analysis of blood donor data from January 2005 to December 2016 was conducted in Blood Bank/Donor Clinic of University of Calabar Teaching Hospital, Calabar, Nigeria...
May 22, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29774840/widespread-treponema-pallidum-infection-in-nonhuman-primates-tanzania
#2
Idrissa S Chuma, Emmanuel K Batamuzi, D Anthony Collins, Robert D Fyumagwa, Luisa K Hallmaier-Wacker, Rudovick R Kazwala, Julius D Keyyu, Inyasi A Lejora, Iddi F Lipende, Simone Lüert, Filipa M D Paciência, Alexander Piel, Fiona A Stewart, Dietmar Zinner, Christian Roos, Sascha Knauf
We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015-2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Our findings indicate that T. pallidum infection is geographically widespread in Tanzania and occurs in several species (olive baboons, yellow baboons, vervet monkeys, and blue monkeys)...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29770281/intestinal-spirochetosis-in-an-immunocompetent-patient
#3
Patricia Guzman Rojas, Jelena Catania, Jignesh Parikh, Tran C Phung, Glenn Speth
Intestinal spirochetosis (IS) is an infestation defined by the presence of spirochetes on the surface of the colonic mucosa. The implicated organisms can be Brachyspira aalborgi or Brachyspira pilosicoli . We present the case of a 66-year-old man with a past medical history of diabetes mellitus, hypertension, morbid obesity, and gastroesophageal reflux. The patient was sent to the gastroenterology clinic for a screening colonoscopy due to a prior history of colonic polyps. The patient was completely asymptomatic as he denies any abdominal pain, diarrhea, melena, or hematochezia...
March 15, 2018: Curēus
https://www.readbyqxmd.com/read/29769048/functional-insights-from-proteome-wide-structural-modeling-of-treponema-pallidum-subspecies-pallidum-the-causative-agent-of-syphilis
#4
Simon Houston, Karen Vivien Lithgow, Kara Krista Osbak, Chris Richard Kenyon, Caroline E Cameron
BACKGROUND: Syphilis continues to be a major global health threat with 11 million new infections each year, and a global burden of 36 million cases. The causative agent of syphilis, Treponema pallidum subspecies pallidum, is a highly virulent bacterium, however the molecular mechanisms underlying T. pallidum pathogenesis remain to be definitively identified. This is due to the fact that T. pallidum is currently uncultivatable, inherently fragile and thus difficult to work with, and phylogenetically distinct with no conventional virulence factor homologs found in other pathogens...
May 16, 2018: BMC Structural Biology
https://www.readbyqxmd.com/read/29767349/-primary-ophthalmological-diagnosis-of-treponema-pallidum-infection-a-case-series
#5
D Grassl, V Brandi Falcone, K Gorte, G Sauder
This report is on five patients (four men and one woman) between the age of 24 and 66 years old who presented with unclear visual impairment in our clinic between 2009 and 2016 for co-evaluation. The clinical picture included intermediate uveitis, chorioretinitis, panuveitis and bilateral spontaneous cystoid macular edema. None of the patients reported systemic or dermatological symptoms. In all five patients, serological testing revealed a Treponema pallidum infection as the reason for ocular inflammation...
May 16, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29758067/correction-identification-of-functional-candidates-amongst-hypothetical-proteins-of-treponema-pallidum-ssp-pallidum
#6
Ahmad Abu Turab Naqvi, Mohd Shahbaaz, Faizan Ahmad, Md Imtaiyaz Hassan
[This corrects the article DOI: 10.1371/journal.pone.0124177.].
2018: PloS One
https://www.readbyqxmd.com/read/29739928/sensitive-detection-of-treponema-pallidum-dna-from-the-whole-blood-of-patients-with-syphilis-by-the-nested-pcr-assay
#7
Cuini Wang, Yuanyuan Cheng, Biao Liu, Yuanyuan Wang, Weiming Gong, Yihong Qian, Zhifang Guan, Haikong Lu, Xin Gu, Mei Shi, Pingyu Zhou
The aim of this work was to investigate the application of the nested PCR assay for the detection of Treponema pallidum (TP) DNA from the blood of patients with different stages of syphilis. In this study, a nested PCR method targeting the Tpp47 and polA genes (Tpp47-Tp-PCR and polA-Tp-PCR) was developed to detect TP-DNA in whole blood samples collected from 262 patients with different stages of syphilis (84 primary syphilis, 97 secondary syphilis, and 81 latent syphilis patients). The PCR assay detected T...
May 9, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29737273/treatment-outcomes-of-brazilian-inmates-with-treponema-pallidum-and-human-immunodeficiency-virus-infection-a-prospective-cohort-study
#8
Graciela Mendonça Dos Santos Bet, Gleyce Hellen de Almeida de Souza, Júlio Croda, Maísa Estopa Correa, Romário Oliveira de Sales, Ruthe Aline da Silva Santos, Renata Viebrantz Enne Sgarbi, Renata Terumi Shiguematsu Yassuda, Ana Rita Castro Mota Coimbra, Maurício Antônio Pompílio, Simone Simionatto
A prospective cohort study was conducted to evaluate the incidence and treatment outcomes of syphilis and human immunodeficiency virus (HIV) in inmates from Central Brazil. In 2013, 3,363 inmates from 12 prisons in the state of Mato Grosso do Sul were recruited, and 1,614 remained incarcerated after 1 year. The inmates were interviewed, and blood samples were collected for serological testing for Treponema pallidum and HIV infections. Inmates infected with T. pallidum or HIV within the first year were assessed for treatment using prison medical record data, based on Venereal Disease Research Laboratory test results, HIV-1 viral load, and CD4 counts...
May 7, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29730886/primary-syphilis-occurring-as-extensive-ulceration-on-the-palatal-gingival-mucosa-diagnosed-by-immunohistochemical-stain
#9
Norberto Sugaya, Paulo H Braz-Silva, Mariana L Bergamini, Dante Migliari
Syphilis is an infectious disease caused by Treponema pallidum, a spirochete microorganism that is pathogenic only to humans. Its transmission occurs predominantly by sexual contact. Clinically, it has four stages: primary, secondary, latent, and tertiary. In most instances, the diagnosis is made during the secondary stage, on which lesions are more numerous, symptomatic, and may affect skin and mucosa areas simultaneously. On the other hand, the primary stage manifests by single, usually painless, ulceration that goes into spontaneously healing between 2 to 4 weeks after its appearance...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29721241/syphilis-infection-in-an-hiv-patient-presenting-with-leukemoid-reaction-case-report-and-review-of-the-literature
#10
Athina Lioni, Markela-Pagonitsa Zorzou, Christina Kollia, Dimitrios Loulakis, Fotini Ntziora, Fotini Stergiou, Maria Boboli, Maria Chini
Leukemoid reaction (LR) is an uncommon though dreadful sign for the treating physician, as it is related to increased mortality. In the few series that have addressed its incidence and clinical significance, infectious causes count for about half of the cases of LR, the rest accounting for cancer, drugs or rarer causes. In the HIV setting, it represents an even rarer event, owing probably to the impaired granulocytic response of AIDS patients to bacterial agents. However no report exists as to the incidence of LR to the immune-restored HIV patients adequately treated with antiretroviral therapy (ART)...
March 29, 2018: Infectious Disease Reports
https://www.readbyqxmd.com/read/29706150/neurosyphilis-mighty-imitator-forays-with-benign-presentation-and-unique-neuroimaging-findings
#11
Harmanpreet Tiwana, Aiesha Ahmed
Background: Common causes of temporal lobe hyper intensities are central nervous system infections like herpes simplex encephalitis, Lyme disease, limbic encephalitis and vascular pathology like Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy. Methods: Personal assessment, laboratory data analysis and neuroimaging for the patient who was admitted to a central Pennsylvania tertiary care referral centre were conducted. Results: A 52-year-old male presented with a 1-year history of diffuse dysesthesia in upper and lower extremities with associated intermittent headaches and neck stiffness...
April 30, 2018: Sexual Health
https://www.readbyqxmd.com/read/29701849/origin-of-nontreponemal-antibodies-during-treponema-pallidum-infection-evidence-from-a-rabbit-model
#12
Kun Gao, Xu Shen, Yong Lin, Xiao-Zhen Zhu, Li-Rong Lin, Man-Li Tong, Yao Xiao, Hui-Lin Zhang, Xian-Ming Liang, Jian-Jun Niu, Li-Li Liu, Tian-Ci Yang
The origin of nontreponemal antibodies during syphilis infection is hotly debated. Here, we analysed the immune response in rabbits immunized with various antigens. Inactivated treponemes elicited the production of low-titre nontreponemal antibodies in some rabbits. Cardiolipin combined with bovine serum albumin also induced anti-cardiolipin antibody production. These findings indicate that T. pallidum contained a cardiolipin antigen with weak immunogenicity. However, active T.pallidum induced higher nontreponemal antibody production with strong immunogenicity at an earlier time point, and the antibody titre was consecutive, suggesting the high nontreponemal antibody titre resulted from the combined effects of both the T...
April 25, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29701397/syphilitic-aortitis-diagnosis-in-clinical-setting
#13
Bruno Fernandes, Arsénio Santos, Lina Carvalho
INTRODUCTION: Cardiovascular syphilis can manifest as aortic aneurysms, aortic regurgitation and coronary ostial stenosis. Tertiary syphilis was the most commom reported cause of thoracic aortic aneurysm in the pre-antibiotic era, contributing to 5- 10% of cardiovascular deaths. However, in the 21st century, it has virtually disappered from the devoloping nations. Tertiay syphilis may develop in about one third of cases of untreated syphilis. In the pre-penicilin era, it was calculated that cardiovascular syphilis was responsible for 10-15% of clinical syphilis...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29676865/detecci%C3%A3-n-de-treponema-pallidum-subespecie-pallidum-para-el-diagn%C3%A3-stico-de-s%C3%A3-filis-cong%C3%A3-nita-mediante-reacci%C3%A3-n-en-cadena-de-la-polimerasa-anidada
#14
Gladys Pinilla, Lesly Campos, Andrea Durán, Jeannette Navarrete, Liliana Muñoz
Introducción. La sífilis es una enfermedad producida por Treponema pallidum subespecie pallidum cuya incidencia mundial es de 12 millones de casos por año, aproximadamente; de estos, más de dos millones se presentan en mujeres gestantes, siendo la sífilis congénita la complicación más grave de esta infección en el embarazo.Objetivo. Detectar la presencia de T. pallidum subespecie pallidum en muestras clínicas para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa (PCR) anidada y determinar su concordancia con las pruebas serológicas...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29670780/syphilis-related-eye-disease-presenting-as-bilateral-papilledema-retinal-nerve-fiber-layer-hemorrhage-and-anterior-uveitis-in-a-penicillin-allergic-patient
#15
Jamie Dietze, Shane Havens
Purpose . Treponema pallidum is known as the "great masquerader" for its many presentations and ocular findings in patients who are infected and develop secondary and tertiary stage of syphilis. Syphilitic ocular manifestations include uveitis, chorioretinitis, retinitis, vasculitis, vitritis, and panuveitis all with or without decreased visual acuity. Human immunodeficiency virus (HIV) is known to expedite the progression of syphilis when patients are coinfected, thus compounding the potential ophthalmic presentations...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29656208/akt-mtor-and-nf-%C3%AE%C2%BAb-pathway-activation-in-treponema-pallidum-stimulates-m1-macrophages
#16
Li-Rong Lin, Zheng-Xiang Gao, Yong Lin, Xiao-Zhen Zhu, Wei Liu, Dan Liu, Kun Gao, Man-Li Tong, Hui-Lin Zhang, Li-Li Liu, Yao Xiao, Jian-Jun Niu, Fan Liu, Tian-Ci Yang
The polarization of macrophages and the molecular mechanism involved during the early process of syphilis infection remain unknown. This study was conducted to explore the influence of Treponema pallidum (T. pallidum) treatment on macrophage polarization and the Akt-mTOR-NFκB signaling pathway mechanism involved in this process. M0 macrophages derived from the phorbol-12-myristate-13-acetate-induced human acute monocytic leukemia cell line THP-1 were cultured with T. pallidum. T. pallidum induced inflammatory cytokine (IL-1β and TNF-α) expression in a dose- and time-dependent manner...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29650059/labyrinthitis-ossificans-in-a-cynomolgus-macaque-macaca-fascicularis
#17
Gayathriy Balamayooran, Hannah M Atkins, Christopher T Whitlow, Samuel T Aycock, Michael A Nader, J Mark Cline, David L Caudell
Labyrinthitis is inflammation of the membranous and bony labyrinth of the inner ear. Typical portals of entry includehematogenous spread from the cochlear vasculature, passage of otitis media pathogens through the round window, and mostcommonly, meningogenic spread from the subarachnoid space. The sequela of chronic inner ear inflammation is labyrinthitisossificans, in which inner ear structures are replaced by fibrous and osseous tissues. Labyrinthitis in humans has been reportedconcurrently with infection due to various viruses (for example, varicella-zoster, measles, mumps) and bacteria (for example,Treponema pallidum, Streptococcus pneumoniae) and may be associated with vertebrobasilar ischemia and meningitis...
April 12, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29649256/gene-target-selection-for-loop-mediated-isothermal-amplification-for-rapid-discrimination-of-treponema-pallidum-subspecies
#18
Sascha Knauf, Simone Lüert, David Šmajs, Michal Strouhal, Idrissa S Chuma, Sieghard Frischmann, Mohammed Bakheit
We show proof of concept for gene targets (polA, tprL, and TP_0619) that can be used in loop-mediated isothermal amplification (LAMP) assays to rapidly differentiate infection with any of the three Treponema pallidum subspecies (pallidum (TPA), pertenue (TPE), and endemicum (TEN)) and which are known to infect humans and nonhuman primates (NHPs). Four TPA, six human, and two NHP TPE strains, as well as two human TEN strains were used to establish and validate the LAMP assays. All three LAMP assays were highly specific for the target DNA...
April 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29629652/utility-of-antitreponemal-igm-testing-in-the-diagnosis-of-early-and-repeat-syphilis-among-hiv-infected-and-non-infected-patients
#19
Maciej Pastuszczak, Agnieszka Kotnis-Gąska, Bernadetta Jakubowicz, Iwona Martyka, Monika Bociaga-Jasik, Anna Wojas-Pelc
Until now only non-treponemal tests (e.g. rapid plasma reagin [RPR]) have been used to monitor syphilis activity (e.g. distinguishing between treated, untreated and repeat disease) and efficacy of treatment. However, they usually require manual operation and are less specific than treponemal tests. The aim of the current study was to evaluate the use of the antitreponemal IgM testing in the diagnosis of early and repeat syphilis in HIV-infected and non-infected patients. One hundred and seventeen patients with early syphilis were included in this prospective study...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29624562/congenital-syphilis-prevention-strategies-evidence-and-future-directions
#20
Rosalyn E Plotzker, Ryan D Murphy, Juliet E Stoltey
BACKGROUND: Congenital syphilis (CS) - the preventable transmission of Treponema pallidum from infected mother to fetus - remains a significant problem worldwide. METHODS: From July through November 2017, 239 articles relevant to CS prevention were identified via keyword searches in PubMed and Google Scholar, ancestry searches, and expert recommendation. Articles were then assessed for 1) measurement of a specified CS or adverse pregnancy outcome (APOs) and 2) geographic setting in high/upper middle income countries according to United Nations criteria...
April 5, 2018: Sexually Transmitted Diseases
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