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Treponema pallidum

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https://www.readbyqxmd.com/read/29325576/reanalysis-of-chinese-treponema-pallidum-samples-all-chinese-samples-cluster-with-ss14-like-group-of-syphilis-causing-treponemes
#1
Michal Strouhal, Jan Oppelt, Lenka Mikalová, Natasha Arora, Kay Nieselt, Fernando González-Candelas, David Šmajs
OBJECTIVE: Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis. Genetic analyses of TPA reference strains and human clinical isolates have revealed two genetically distinct groups of syphilis-causing treponemes, called Nichols-like and SS14-like groups. So far, no genetic intermediates, i.e. strains containing a mixed pattern of Nichols-like and SS14-like genomic sequences, have been identified. Recently, Sun et al. (Oncotarget 2016. https://doi.org/10.18632/oncotarget...
January 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29318719/crystal-structures-of-mglb-2-tp0684-a-topologically-variant-d-glucose-binding-protein-from-treponema-pallidum-reveal-a-ligand-induced-conformational-change
#2
Chad A Brautigam, Ranjit K Deka, Wei Z Liu, Michael V Norgard
Previously, we determined the crystal structure of apo-TpMglB-2, a D-glucose-binding component of a putative ABC transporter from the syphilis spirochete Treponema pallidum. The protein had an unusual topology for this class of proteins, raising the question of whether the D-glucose-binding mode would be different in TpMglB-2. Here, we present the crystal structures of a variant of TpMglB-2 with and without D-glucose bound. The structures demonstrate that, despite its aberrant topology, the protein undergoes conformational changes and binds D-glucose similarly to other Mgl-type proteins, likely facilitating D-glucose uptake in T...
January 10, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29309603/a-non-human-primate-model-for-rectally-transmitted-syphilis
#3
Cassandra Tansey, Chunxia Zhao, Andre Hopkins, Jana M Ritter, Yetunde F Fakile, Allan Pillay, Samantha S Katz, Lara Pereira, James Mitchell, Frank Deyounks, Ellen N Kersh, Janet M McNicholl, Sundaram Ajay Vishwanathan
Men, diagnosed with syphilis or other rectal sexually transmitted infections (STIs), who have sex with men (MSM) are at a higher risk for HIV acquisition, which is concerning given the large increase in recently reported syphilis cases in the United States. We have developed the first non-human primate model for rectally transmitted syphilis by exposing SHIV-infected and naïve rhesus macaques to Treponema pallidum in the rectum. All animals showed mucosal lesions, systemic dissemination, and seroconversion (treponemal antibodies)...
December 22, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29304083/combined-evaluation-of-sexually-transmitted-infections-in-hiv-infected-pregnant-women-and-infant-hiv-transmission
#4
Kristina Adachi, Jiahong Xu, Nava Yeganeh, Margaret Camarca, Mariza G Morgado, D Heather Watts, Lynne M Mofenson, Valdilea G Veloso, Jose Henrique Pilotto, Esau Joao, Glenda Gray, Gerhard Theron, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Mariana Ceriotto, Daisy Maria Machado, Yvonne J Bryson, Beatriz Grinsztejn, Jack Moye, Jeffrey D Klausner, Claire C Bristow, Ruth Dickover, Mark Mirochnick, Karin Nielsen-Saines
BACKGROUND: Sexually transmitted infections (STIs) including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and cytomegalovirus (CMV) may lead to adverse pregnancy and infant outcomes. The role of combined maternal STIs in HIV mother-to-child transmission (MTCT) was evaluated in mother-infant pairs from NICHD HPTN 040. METHODOLOGY: Urine samples from HIV-infected pregnant women during labor were tested by polymerase chain reaction (PCR) for CT, NG, and CMV...
2018: PloS One
https://www.readbyqxmd.com/read/29281641/development-of-a-multilocus-sequence-typing-mlst-scheme-for-treponema-pallidum-subsp-pertenue-application-to-yaws-in-lihir-island-papua-new-guinea
#5
Charmie Godornes, Lorenzo Giacani, Alyssa E Barry, Oriol Mitja, Sheila A Lukehart
BACKGROUND: Yaws is a neglected tropical disease, caused by Treponema pallidum subsp. pertenue. The disease causes chronic lesions, primarily in young children living in remote villages in tropical climates. As part of a global yaws eradication campaign initiated by the World Health Organization, we sought to develop and evaluate a molecular typing method to distinguish different strains of T. pallidum subsp. pertenue for disease control and epidemiological purposes. METHODS AND PRINCIPAL FINDINGS: Published genome sequences of strains of T...
December 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29277436/-the-key-role-of-the-pathologist-in-the-diagnosis-of-syphilis-a-case-report
#6
Cécile Picard, Juliette Fontaine, Brigitte Chouvet, Brigitte Balme, Alexandra Traverse-Glehen
Syphilis is a resurging sexually transmitted infection linked to Treponema Pallidum. Syphilitic lymphadenitis can be present during the 3 stages of the disease. Its histological diagnosis remains challenging for the pathologist given its possible misleading aspect and its ability to mimic as well as reactional as tumoral conditions. We report the case of an HIV-infected young patient referred for suspicion of an aggressive lymphoma. Histological and immunohistochemical analysis of cervical lymphadenopathy revealed secondary syphilis...
December 22, 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/29240636/the-etiology-of-genital-ulcer-disease-and-coinfections-with-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-zimbabwe-results-from-the-zimbabwe-sti-etiology-study
#7
More Mungati, Anna Machiha, Owen Mugurungi, Mufuta Tshimanga, Peter H Kilmarx, Justice Nyakura, Gerald Shambira, Vitalis Kupara, David A Lewis, Elizabeth Gonese, Beth A Tippett Barr, H Hunter Handsfield, Cornelis A Rietmeijer
BACKGROUND: In many countries, sexually transmitted infections (STIs) are treated syndromically. Thus, patients diagnosed as having genital ulcer disease (GUD) in Zimbabwe receive a combination of antimicrobials to treat syphilis, chancroid, lymphogranuloma venereum (LGV), and genital herpes. Periodic studies are necessary to assess the current etiology of GUD and assure the appropriateness of current treatment guidelines. MATERIALS AND METHODS: We selected 6 geographically diverse clinics in Zimbabwe serving high numbers of STI cases to enroll men and women with STI syndromes, including GUD...
January 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29236656/secondary-syphilis-associated-with-membranous-nephropathy-and-acute-hepatitis-in-a-patient-with-hiv-a-case-report
#8
Zhou Zhang, Aviv Hever, Nitin Bhasin, Dean A Kujubu
INTRODUCTION: We present a case of membranous nephropathy associated with a secondary syphilis infection in a patient with HIV. CASE PRESENTATION: A 37-year-old white man with HIV who was receiving highly active antiretroviral therapy presented to the Emergency Department with 6 weeks of rectal pain. He had a CD3-CD4 count of 656 cells/mm3 and an undetectable viral load. On admission, he was found to have an anal ulcer, a serum creatinine of 1.4 mg/dL (baseline 0...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29229275/frequency-of-treponema-pallidum-invasion-into-cerebrospinal-fluid-in-primary-or-secondary-early-stage-syphilis
#9
Mao Hagihara, Yuka Yamagishi, Hideo Kato, Yuichi Shibata, Arufumi Shiota, Daisuke Sakanashi, Hiroyuki Suematsu, Hiroki Watanabe, Nobuhiro Asai, Yusuke Koizumi, Tatsuro Furui, Seiichiro Takahashi, Koji Izumi, Hiroshige Mikamo
Frequency of Treponema pallidum invasion into cerebrospinal fluid (CSF) has not been clear at this present. Since it is impossible to culture T. pallidum in vitro at this present, we need molecular based-approach to detect it in CSF. Additionally, neurosyphilis is usually a late sequela, however it might result in asymptomatic neurosyphilis even at primary or secondary syphilis. This study was to reveal the frequency of T. pallidum invasion into CSF especially at primary or secondary syphilis with polymerase chain reaction (PCR) test...
December 8, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29228176/screening-and-identification-of-immunoactive-flab-protein-fragments-of-treponema-pallidum-for-the-serodiagnosis-of-syphilis
#10
Manyi Tan, Man Xu, Yongjian Xiao, Yafeng Xie, Chuanhao Jiang, Kang Zheng, Qian Chen, Feijun Zhao, Tiebing Zeng, Yimou Wu
Flagellin is a classical pathogen-associated molecular pattern that can evoke robust immune response. We have demonstrated previously that three full-length flagellins of Treponema pallidum, namely FlaB1, FlaB2 and FlaB3, did have diagnostic value in serodiagnosis of syphilis. Here, we selected and constructed three recombinant fragments of each complete FlaB, both the conserved N-terminal and the C-terminal region, and the middle variable part, with the goal of exploring fragment unique to Treponema pallidum for use as antigen target in a fragment based serological test...
December 5, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29225977/double-morphology-tertiary-syphilis-and-acquired-immunodeficiency-syndrome-a-rare-association
#11
R M Ngwanya, B Kakande, N P Khumalo
Background: Human immunodeficiency virus (HIV) and Treponema pallidum coinfection is relatively common and accounts for about 25% of primary and secondary syphilis. Tertiary syphilis in HIV-uninfected and HIV-infected patients is vanishingly rare. This is most likely due to early treatment of cases of primary and secondary syphilis. There is rapid progression to tertiary syphilis in HIV-infected patients. Case Presentation: A 49-year-old woman diagnosed with HIV Type 1 infection and cluster of differentiation 4 (CD4) count of 482 presented with a four-week history of multiple crusted plaques, nodules, and ulcers on her face, arms, and abdomen...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29223963/field-evaluation-of-two-point-of-care-tests-for-syphilis-among-men-who-have-sex-with-men-verona-italy
#12
Antonella Zorzi, Maddalena Cordioli, Lorenzo Gios, Paola Del Bravo, Igor Toskin, Rosanna W Peeling, Karel Blondeel, Giuseppe Cornaglia, James Kiarie, Ronald Ballard, Massimo Mirandola
OBJECTIVES: The incidence of HIV and syphilis among men who have sex with men (MSM) in Europe has recently increased. Rapid point-of-care tests (POCTs) for syphilis can improve access to screening. The purpose of this study was to evaluate the performance of two syphilis POCTs compared with laboratory tests among MSM. METHODS: The study was undertaken in Verona, Italy. Asymptomatic MSM, potentially exposed to syphilis, were enrolled prospectively. The POCTs evaluated were SD Bioline Syphilis 3...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29201173/serological-evaluation-of-antigen-tp0693-for-diagnosis-of-syphilis
#13
Li Zhang, Meixia Deng, Xiaohong Zhang, Weiguo Yin, Wen Liu, Xi Luo, Jie Yang, Fei Chen, Feijun Zhao
The aim of the present study was to evaluate the diagnostic value of the Treponema pallidum (Tp) antigen Tp0693 for syphilis. ELISA was used to examine the serum levels of Tp0693. The sample-to-cutoff ratio (S/CO) value was used to generate a receiver operating characteristic (ROC) curve. A correlation analysis was performed to compare the detection efficacy of Tp0693-specific ELISA, Treponema pallidum Particle Agglutination (TPPA), Tolulized Red Unheated Serum test (TRUST) and LiZhu™ Tp-ELISA. The area under the ROC curve was 0...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29199801/relevance-in-biology-and-mechanisms-of-immune-and-treatment-evasion-of-treponema-pallidum-a-review
#14
Francesco Drago, Sanja Javor, Aurora Parodi
INTRODUCTION: During syphilis a compelling fight is engaged between the host's humoral and cellular immune responses that work to eliminate the infection and Treponema pallidum (T. pallidum) that manages to evade eradication and cause chronic infection. Different mechanisms are utilized by treponemes to overcome immunological response. Although penicillin (BPG) proved to be effective in quelling the early manifestations of the disease and consequently its contagiousness, questions remain about its ability to prevent the late complications and to provide a microbiological eradication in vivo...
December 1, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29198180/converging-epidemics-of-sexually-transmitted-infections-and-bacterial-vaginosis-in-southern-african-female-adolescents-at-risk-of-hiv
#15
Shaun L Barnabas, Smritee Dabee, Jo-Ann S Passmore, Heather B Jaspan, David A Lewis, Shameem Z Jaumdally, Hoyam Gamieldien, Lindi Masson, Etienne Muller, Venessa D Maseko, Nonhlanhla Mkhize, Zizipho Mbulawa, Anna-Lise Williamson, Clive M Gray, Thomas J Hope, Francesca Chiodi, Janan Dietrich, Glenda Gray, Linda-Gail Bekker
Adolescents in Africa are at high risk for HIV infection, other sexually transmitted infections (STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence HIV risk, behavioral risk factors and prevalence of STIs/BV were compared in HIV-seronegative adolescent females (n = 298; 16-22 years) from two South African communities (Soweto and Cape Town). STIs ( Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, herpes simplex virus (HSV)-1, HSV-2, Treponema pallidum, and Haemophilus ducreyi) were detected by multiplex polymerase chain reaction, human papillomavirus (HPV) by Roche Linear Array, and BV by Nugent scoring...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29196305/multiple-simultaneous-infections-in-a-patient-with-well-controlled-hiv-when-occam-s-razor-fails
#16
Miranda Sherley, Sarah Jane Martin
Multiple concurrent infectious processes have previously been reported in the context of advanced HIV with significant immunosuppression. Here we report a case of multiple infections in a 56-year-old man with well-controlled HIV diagnosed 5 years earlier. Soon after returning to Australia following 12 years living in Thailand, he became unwell with fevers, night sweats, arthralgia and myalgia. There were no localising symptoms and examination was unremarkable. Investigations revealed positive syphilis (Treponema pallidum) serology with an RPR of 16, a positive urine culture (Klebsiella pneumoniae), a pulmonary nodule, a liver abscess and colitis (Entamoeba histolytica)...
December 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29194668/is-an-endoscopic-examination-associated-with-transfusion-transmissible-infections-a-systematic-review-and-meta-analysis
#17
REVIEW
Hans Van Remoortel, Vere Borra, Emmy De Buck, Veerle Compernolle, Philippe Vandekerckhove
BACKGROUND: The purpose of a donor medical questionnaire is to identify the blood donor's history relative to the current known blood-safety risks. A temporary deferral from blood donation after an endoscopic examination is enforced because of the reusable nature of the endoscope and close contact with the inner body. The objective of this systematic review was to find the best available evidence on the association between an endoscopic examination and the risk of transfusion-transmissible infections...
November 30, 2017: Transfusion
https://www.readbyqxmd.com/read/29184321/rapid-response-to-syphilis-outbreak-among-female-sex-workers
#18
Shaily B Surti, J K Kosambiya, Neeta Khokhar, Mohamedanas Mohamedfaruk Patni, Alpesh H Gohil, Zeel N Kamdar, Dipak Umrigar, Ragini Verma, Summaiya Mulla
Background: Outbreak of syphilis, i.e., 16 cases of rapid plasma reagin (RPR) reactive cases of syphilis was reported in Community Based Organization (CBO) Sahyog of Surat, India, from April to August 2014. The aim of the study was to find risk factors and take immediate actions to prevent spread. Materials and Methods: Outbreak investigation of 16 Female Sex Workers of CBO Sahyog in Surat who were found Rapid Plasma Reagin (RPR) and Treponema Pallidum Hemagglutination Assay (TPHA) positive from April to August 2014; was carried out...
October 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29168582/diagnostic-value-of-trait-antinuclear-antibodies-and-multiple-immunoglobulin-production-in-autoimmune-diseases
#19
Liping Wan, Hong Zhu, Yanan Gu, Hui Liu
BACKGROUND: Our article aims to evaluate the proportion of monospecific antinuclear antibodies (ANA) and polyclonal ANAs in patients with autoimmune diseases based on the results of an ANA panel and to evaluate the efficiency of trait ANAs as a novel diagnostic tool. This study also aims to investigate immunoglobulin production in autoimmune diseases by detecting different antibodies. METHODS: The serum ANA profile of 634 patients with autoimmune diseases was analyzed using the immunoblot method...
November 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29167762/lncrna-expression-in-cd4-t-cells-in-neurosyphilis-patients
#20
Li-Li Liu, Shao-Gang Zhu, Xiao-Yong Jiang, Jun Ren, Yong Lin, Ning-Ning Zhang, Man-Li Tong, Hui-Lin Zhang, Wei-Hong Zheng, Hua-Jun Fu, Hai-Juan Luo, Li-Rong Lin, Jiang-Hua Yan, Tian-Ci Yang
Recent studies have shown that several long noncoding RNAs (lncRNAs) are involved in regulating the immune response to cope with pathogenic invasion. To date, the roles of lncRNAs in the CD4+ T cell response to Treponema pallidum (T. pallidum) infection in neurosyphilis patients remain unknown. The mRNA and lncRNA expression profiles of CD4+ T cells that were isolated from neurosyphilis patients and healthy controls were analyzed by microarray. A total of 2258 lncRNAs and 1728 mRNAs were identified as over-expressed or under-expressed, respectively (fold change > 1...
2017: Frontiers in Cellular and Infection Microbiology
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