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T. pallidum

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https://www.readbyqxmd.com/read/28525592/neurosyphilis-increases-hiv-associated-central-nervous-system-inflammation-but-does-not-explain-cognitive-impairment-in-hiv-infected-individuals-with-syphilis
#1
Emily L Ho, Clare L Maxwell, Shelia B Dunaway, Sharon K Sahi, Lauren C Tantalo, Sheila A Lukehart, Christina M Marra
Background: HIV-infected individuals with previous syphilis have cognitive impairment. We tested the hypothesis that neurosyphilis causes cognitive impairment in HIV by amplifying HIV-related CNS inflammation. Methods: 132 HIV-infected participants enrolled in a study of CSF abnormalities in syphilis underwent the mental alternation test (MAT), venipuncture and lumbar puncture. CSF concentrations of chemokine (C-X-C motif) ligand 10 (CXCL10), chemokine (C-C motif) ligand 2 (CCL2) and neurofilament light (NFL) were determined by commercial assays...
May 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28523273/novel-treponema-pallidum-recombinant-antigens-for-syphilis-diagnostics-current-status-and-future-prospects
#2
REVIEW
Aleksey Kubanov, Anastassia Runina, Dmitry Deryabin
The recombinant protein technology considerably promoted the development of rapid and accurate treponema-specific laboratory diagnostics of syphilis infection. For the last ten years, the immunodominant recombinant inner membrane lipoproteins are proved to be sensitive and specific antigens for syphilis screening. However, the development of an enlarged T. pallidum antigen panel for diagnostics of early and late syphilis and differentiation of syphilis stages or cured syphilis remains as actual goal of multidisciplinary expertise...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28498277/influence-of-visceral-interoceptive-experience-on-the-brain-s-response-to-food-images-in-anorexia-nervosa
#3
Kara L Kerr, Scott E Moseman, Jason A Avery, Jerzy Bodurka, W Kyle Simmons
OBJECTIVE: To determine how visceral sensations affect responses to food stimuli in anorexia nervosa (AN). METHODS: Twenty weight-restored, unmedicated adolescent and young adult women with AN and twenty healthy control participants completed an interoceptive attention task during which they focused on sensations from the heart, stomach, and bladder and made ratings of these sensations. They then underwent fMRI scanning while viewing pictures of food and non-food objects...
May 12, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28489855/haemophilus-ducreyi-dna-is-detectable-on-the-skin-of-asymptomatic-children-flies-and-fomites-in-villages-of-papua-new-guinea
#4
Wendy Houinei, Charmie Godornes, August Kapa, Sascha Knauf, Eric Q Mooring, Camila González-Beiras, Ronald Watup, Raymond Paru, Paul Advent, Sivauk Bieb, Sergi Sanz, Quique Bassat, Stanley M Spinola, Sheila A Lukehart, Oriol Mitjà
BACKGROUND: Haemophilus ducreyi and Treponema pallidum subsp. pertenue are major causes of leg ulcers in children in Africa and the Pacific Region. We investigated the presence of DNA (PCR positivity) from these bacteria on asymptomatic people, flies, and household linens in an endemic setting. METHODOLOGY/PRINCIPAL FINDINGS: We performed a cross-sectional study in rural villages of Lihir Island, Papua New Guinea during a yaws elimination campaign. Participants were asymptomatic subjects recruited from households with cases of leg ulcers, and from households without cases of leg ulcers...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28484511/reducing-risks-of-transfusion-transmitted-infections-in-a-resource-limited-hospital-based-blood-bank-the-case-of-the-yaound%C3%A3-university-teaching-hospital-cameroon
#5
C T Tagny, A Ndoumba, S Laperche, E Murphy, D Mbanya
BACKGROUND AND OBJECTIVES: Although interest in assessing risk of TTIs, very few trends in blood safety epidemiological data from resource-limited blood services are reported in the literature. This analysis aims at reporting trends in seroprevalences of TTIs in blood donations in the Yaoundé University Teaching Hospital (UTH) from 2011 to 2015 and to describe reasons for these changes. MATERIALS AND METHODS: All donations of 2015 were tested for HIV 1&2 antibodies and the P24 antigen, HBsAg, HCV antibody and the Treponema pallidum antibody...
August 2016: ISBT Science Series
https://www.readbyqxmd.com/read/28484210/identification-of-tp0751-pallilysin-as-a-treponema-pallidum-vascular-adhesin-by-heterologous-expression-in-the-lyme-disease-spirochete
#6
Wei-Chien Andrew Kao, Helena Pětrošová, Rhodaba Ebady, Karen V Lithgow, Pablo Rojas, Yang Zhang, Yae-Eun Kim, Yae-Ram Kim, Tanya Odisho, Nupur Gupta, Annette Moter, Caroline E Cameron, Tara J Moriarty
Treponema pallidum subsp. pallidum, the causative agent of syphilis, is a highly invasive spirochete pathogen that uses the vasculature to disseminate throughout the body. Identification of bacterial factors promoting dissemination is crucial for syphilis vaccine development. An important step in dissemination is bacterial adhesion to blood vessel surfaces, a process mediated by bacterial proteins that can withstand forces imposed on adhesive bonds by blood flow (vascular adhesins). The study of T. pallidum vascular adhesins is hindered by the uncultivable nature of this pathogen...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28484042/a-proteomic-signature-of-dormancy-in-an-actinobacterium-micrococcus-luteus
#7
Sujina Mali, Morgan Mitchell, Spencer Havis, Abiodun Bodunrin, Jonathan Rangel, Gabriella Olson, William R Widger, Steven J Bark
Dormancy is a protective state where diverse bacteria including M. tuberculosis, S. aureus, T. pallidum (syphilis), and B. burgdorferi (Lyme Disease) curtail metabolic activity to survive external stresses including antibiotics. Evidence suggests dormancy consists of a continuum of interrelated states including viable but nonculturable (VBNC) and persistence states. VBNC and persistence contribute to antibiotic tolerance, reemergence from latent infections, and even quorum sensing and biofilm formation. Previous studies indicate that the protein mechanisms regulating persistence and VBNC states are not well understood...
May 8, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28456488/secondary-syphilis-mimicking-malignancy-a-case-report-and-review-of-literature
#8
Claudio Cerchione, Alberto Enrico Maraolo, Luana Marano, Novella Pugliese, Davide Nappi, Grazia Tosone, Ilaria Cimmino, Imma Cozzolino, Vincenzo Martinelli, Fabrizio Pane, Marco Picardi
A 56-year-old man developed disseminate lymphadenopathies, associated with hepato-splenomegaly, fever, nocturnal sweating and weight loss. Imaging studies in particular FDG-PET/CT raised the suspicion of a malignant disease. But blood flow cytometry assay for B/T cell clonality was negative and fine-needle biopsy of enlarged laterocervical lymph node showed a not specific "reactive hyperplasia". Four months later, the patient developed a non-itching rash; since a further anamnestic investigation revealed an history of high-risk sexual intercourse, the patient underwent serological tests for Treponema pallidum that were positive at high titer, after a first negative screening...
April 26, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28411158/intrinsic-membrane-properties-and-cholinergic-modulation-of-mouse-basal-forebrain-glutamatergic-neurons-in-vitro
#9
Chun Yang, James T McKenna, Ritchie E Brown
The basal forebrain (BF) controls sleep-wake cycles, attention and reward processing. Compared to cholinergic and GABAergic neurons, BF glutamatergic neurons are less well understood, due to difficulties in identification. Here, we use vesicular glutamate transporter 2 (vGluT2)-tdTomato mice, expressing a red fluorescent protein (tdTomato) in the major group of BF glutamatergic neurons (vGluT2+) to characterize their intrinsic electrical properties and cholinergic modulation. Whole-cell, patch-clamp recordings were made from vGluT2+ neurons in coronal BF slices...
June 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28410389/molecular-subtyping-of-treponema-pallidum-and-associated-factors-of-serofast-status-in-early-syphilis-patients-identified-novel-genotype-and-cytokine-marker
#10
Rui-Li Zhang, Qian-Qiu Wang, Jin-Ping Zhang, Li-Jia Yang
Serofast, a persistent nontreponemal serological response observed in early syphilis patients after conventional treatment, remains a concern of clinicians and syphilis patients. No consensus has been established, however, that defines an effective treatment strategy and clarifies the pathogenesis. In this study, 517 patients with early syphilis were enrolled and treated. Twelve months after treatment, 79.3% (410/517) of patients achieved serological cure, 20.1% (104/517) were serofast, and 0.6% (3/517) were serological failures...
2017: PloS One
https://www.readbyqxmd.com/read/28399709/treponema-pallidum-ssp-pallidum-identification-by-real-time-pcr-targetting-the-pola-gene-in-paraffin-embedded-samples-positive-by-immunohistochemistry
#11
A Gama, E M Carrillo-Casas, R Hernández-Castro, V A Vázquez-Aceituno, S Toussaint-Caire, J Xicohtencatl-Cortes, R Fernández-Martínez, G Moreno-Coutiño
Syphilis is a systemic and sexually transmitted infection caused by Treponema pallidum ssp. pallidum. This spirochete causes different clinical and subclinical stages depending on the duration of infection and immune status of the host. Several tests have been developed for diagnosis, and are classified into direct and indirect methods. The first one includes dark field microscopy, direct fluorescent antibody test in fluids or tissue, and molecular biology techniques. In the indirect method (serologic), the routine tests are used, and are divided in two categories: non-treponemal and treponemal ones...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28381602/cerebrospinal-fluid-treponema-pallidum-particle-agglutination-assay-for-neurosyphilis-diagnosis
#12
Christina M Marra, Clare L Maxwell, Shelia B Dunaway, Sharon K Sahi, Lauren C Tantalo
BACKGROUND: Limited data suggest that the cerebrospinal fluid (CSF) Treponema pallidum particle agglutination assay (TPPA) is sensitive and a CSF Treponema pallidum hemagglutination assay (TPHA) titer ≥1:640 is specific for neurosyphilis diagnosis. METHODS: CSF-TPPA reactivity and titer were determined for a convenience sample of 191 CSFs from individuals enrolled in a study of CSF abnormalities in syphilis (training dataset). Sensitivity of a reactive test and specificity for reactivity at serial higher CSF dilutions was determined...
April 5, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28357375/syphilis-re-emergence-of-an-old-foe
#13
REVIEW
Lola V Stamm
Syphilis is caused by infection with Treponema pallidum subsp. pallidum, a not-yet-cultivable spiral-shaped bacterium that is usually transmitted by sexual contact with an infected partner or by an infected pregnant woman to her fetus. There is no vaccine to prevent syphilis. Diagnosis and treatment of infected individuals and their contacts is key to syphilis control programs that also include sex education and promotion of condom use to prevent infection. Untreated syphilis can progress through four stages: primary (chancre, regional lymphadenopathy), secondary (disseminated skin eruptions, generalized lymphadenopathy), latent (decreased re-occurrence of secondary stage manifestations, absence of symptoms), and tertiary (gummas, cardiovascular syphilis and late neurological symptoms)...
June 27, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28346380/constituents-of-the-roots-of-dichapetalum-pallidum-and-their-anti-proliferative-activity
#14
Dorcas Osei-Safo, Godwin Akpeko Dziwornu, Regina Appiah-Opong, Mary Anti Chama, Isaac Tuffour, Reiner Waibel, Richard Amewu, Ivan Addae-Mensah
As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, Dichapetalum pallidum, led to the isolation of the newly occurring 7-hydroxydichapetalin P (1) and the known dichapetalins A (2) and X (3). Also isolated were the known compounds friedelin-2,3-lactone (4), friedelan-3-one (6), friedelan-3β-ol (7) and pomolic (8), as well as the dipeptide aurantiamide acetate (5). The compounds were characterized by direct interpretation of their IR, 1D NMR and 2D NMR spectral data and by comparison of their physico-chemical data, including their chromatographic profiles, with the literature and authentic samples in our compound library for the genus Dichapetalum...
March 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28323127/bi-phase-age-related-brain-gray-matter-magnetic-resonance-t1%C3%AF-relaxation-time-change-in-adults
#15
Yáo T Li, Hua Huang, Zhizheng Zhuo, Pu-Xuan Lu, Weitian Chen, Yì Xiáng J Wáng
OBJECTIVES: To investigate normative value and age-related change of brain magnetic resonance T1ρ relaxation at 1.5T. METHODS: This study was approved by the local ethical committee with participants' written consent obtained. There were 42 adults healthy volunteers, including 20 males (age: 41±16 (mean±standard deviation) years, range: 22-68years,) and 22 females (age: 39±15years, range: 21-62years). MRI was performed at 1.5T using 3D fluid suppressed turbo spin echo sequence...
June 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28321594/disrupted-functional-connectivity-of-periaqueductal-gray-subregions-in-episodic-migraine
#16
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma, Shengyuan Yu
BACKGROUND: The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered functional connectivity of PAG subregions in EM patients. METHODS: The brain structural images and resting state functional MR imaging (rs-fMRI) data were obtained from 18 normal controls (NC) and 18 EM patients on 3.0 T MR system. Seven subregions of PAG were classified as bilateral ventrolateral PAG (vlPAG), lateral PAG (lPAG), dorsolateral PAG (dlPAG) and dorsomedial PAG (dmPAG)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28282646/point-of-care-sexually-transmitted-infection-diagnostics-proceedings-of-the-star-sexually-transmitted-infection-clinical-trial-group-programmatic-meeting
#17
Anthony D Cristillo, Claire C Bristow, Rosanna Peeling, Barbara Van Der Pol, Sasha Herbst de Cortina, Ivan K Dimov, Nitika Pant Pai, Dong Jin Shin, Ricky Y T Chiu, Catherine Klapperich, Purnima Madhivanan, Sheldon R Morris, Jeffrey D Klausner
The goal of the point-of-care (POC) sexually transmitted infection (STI) Diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of POC STI diagnostics. Experts from academia, government, nonprofit, and industry discussed POC diagnostics for STIs such as Chlamydia trachomatis, human papillomavirus, Neisseria gonorrhoeae, Trichomonas vaginalis, and Treponema pallidum. Key objectives included a review of current and emerging technologies, clinical and public health benefits, POC STI diagnostics in developing countries, regulatory considerations, and future areas of development...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28282487/establishment-of-multiplex-solid-phase-strip-pcr-test-for-detection-of-24-ocular-infectious-disease-pathogens
#18
Satoko Nakano, Sunao Sugita, Yasuhiro Tomaru, Ayumi Hono, Takako Nakamuro, Toshiaki Kubota, Hiroshi Takase, Manabu Mochizuki, Masayo Takahashi, Norio Shimizu
Purpose: To establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip PCR) for concurrent detection of common ocular infectious disease pathogens. Methods: A new multiplex strip PCR was established to detect 24 common ocular infectious disease pathogens: herpes simplex virus (HSV) 1, HSV2, varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpes virus (HHV) 6, HHV7, HHV8, human T-cell lymphotropic virus (HTLV)-1, adenovirus, Mycobacterium tuberculosis, Treponema pallidum, Propionibacterium acnes (P...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28266263/case-report-of-three-consecutive-lues-maligna-infections-in-an-hiv-infected-patient
#19
Stefanie Sammet, Rika Draenert
Lues maligna is a rare presentation of an infection with Treponema pallidum. Here we report three lues maligna infections with severe dermatological manifestations in a single HIV-1 infected individual. Despite the start of highly active antiretroviral therapy and a substantial increase in CD4 cell count after the first episode, he developed consecutive episodes. We assume a specific immunological predisposition to react to T. pallidum in this patient.
April 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28240386/genetic-and-environmental-influences-on-mean-diffusivity-and-volume-in-subcortical-brain-regions
#20
Nathan A Gillespie, Michael C Neale, Donald J Hagler, Lisa T Eyler, Christine Fennema-Notestine, Carol E Franz, Michael J Lyons, Linda K McEvoy, Anders M Dale, Matthew S Panizzon, William S Kremen
Increased mean diffusivity (MD) is hypothesized to reflect tissue degeneration and may provide subtle indicators of neuropathology as well as age-related brain changes in the absence of volumetric differences. Our aim was to determine the degree to which genetic and environmental variation in subcortical MD is distinct from variation in subcortical volume. Data were derived from a sample of 387 male twins (83 MZ twin pairs, 55 DZ twin pairs, and 111 incomplete twin pairs) who were MRI scanned as part of the Vietnam Era Twin Study of Aging...
February 27, 2017: Human Brain Mapping
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