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T. pallidum

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https://www.readbyqxmd.com/read/28323127/bi-phase-age-related-brain-gray-matter-magnetic-resonance-t1%C3%AF-relaxation-time-change-in-adults
#1
Yáo T Li, Hua Huang, Zhizheng Zhuo, Pu-Xuan Lu, Weitian Chen, Yì Xiáng J Wáng
OBJECTIVES: To investigate normative value and age-related change of brain magnetic resonance T1ρ relaxation at 1.5T. METHODS: This study was approved by the local ethical committee with participants' written consent obtained. There were 42 adults healthy volunteers, including 20 males (age: 41±16 (mean±standard deviation) years, range: 22-68years,) and 22 females (age: 39±15years, range: 21-62years). MRI was performed at 1.5T using 3D fluid suppressed turbo spin echo sequence...
March 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28321594/disrupted-functional-connectivity-of-periaqueductal-gray-subregions-in-episodic-migraine
#2
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Lin Ma, Shengyuan Yu
BACKGROUND: The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered functional connectivity of PAG subregions in EM patients. METHODS: The brain structural images and resting state functional MR imaging (rs-fMRI) data were obtained from 18 normal controls (NC) and 18 EM patients on 3.0 T MR system. Seven subregions of PAG were classified as bilateral ventrolateral PAG (vlPAG), lateral PAG (lPAG), dorsolateral PAG (dlPAG) and dorsomedial PAG (dmPAG)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28282646/point-of-care-sexually-transmitted-infection-diagnostics-proceedings-of-the-star-sexually-transmitted-infection-clinical-trial-group-programmatic-meeting
#3
Anthony D Cristillo, Claire C Bristow, Rosanna Peeling, Barbara Van Der Pol, Sasha Herbst de Cortina, Ivan K Dimov, Nitika Pant Pai, Dong Jin Shin, Ricky Y T Chiu, Catherine Klapperich, Purnima Madhivanan, Sheldon R Morris, Jeffrey D Klausner
The goal of the point-of-care (POC) sexually transmitted infection (STI) Diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of POC STI diagnostics. Experts from academia, government, nonprofit, and industry discussed POC diagnostics for STIs such as Chlamydia trachomatis, human papillomavirus, Neisseria gonorrhoeae, Trichomonas vaginalis, and Treponema pallidum. Key objectives included a review of current and emerging technologies, clinical and public health benefits, POC STI diagnostics in developing countries, regulatory considerations, and future areas of development...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28282487/establishment-of-multiplex-solid-phase-strip-pcr-test-for-detection-of-24-ocular-infectious-disease-pathogens
#4
Satoko Nakano, Sunao Sugita, Yasuhiro Tomaru, Ayumi Hono, Takako Nakamuro, Toshiaki Kubota, Hiroshi Takase, Manabu Mochizuki, Masayo Takahashi, Norio Shimizu
Purpose: To establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip PCR) for concurrent detection of common ocular infectious disease pathogens. Methods: A new multiplex strip PCR was established to detect 24 common ocular infectious disease pathogens: herpes simplex virus (HSV) 1, HSV2, varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpes virus (HHV) 6, HHV7, HHV8, human T-cell lymphotropic virus (HTLV)-1, adenovirus, Mycobacterium tuberculosis, Treponema pallidum, Propionibacterium acnes (P...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28266263/case-report-of-three-consecutive-lues-maligna-infections-in-an-hiv-infected-patient
#5
Stefanie Sammet, Rika Draenert
Lues maligna is a rare presentation of an infection with Treponema pallidum. Here we report three lues maligna infections with severe dermatological manifestations in a single HIV-1 infected individual. Despite the start of highly active antiretroviral therapy and a substantial increase in CD4 cell count after the first episode, he developed consecutive episodes. We assume a specific immunological predisposition to react to T. pallidum in this patient.
April 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28240386/genetic-and-environmental-influences-on-mean-diffusivity-and-volume-in-subcortical-brain-regions
#6
Nathan A Gillespie, Michael C Neale, Donald J Hagler, Lisa T Eyler, Christine Fennema-Notestine, Carol E Franz, Michael J Lyons, Linda K McEvoy, Anders M Dale, Matthew S Panizzon, William S Kremen
Increased mean diffusivity (MD) is hypothesized to reflect tissue degeneration and may provide subtle indicators of neuropathology as well as age-related brain changes in the absence of volumetric differences. Our aim was to determine the degree to which genetic and environmental variation in subcortical MD is distinct from variation in subcortical volume. Data were derived from a sample of 387 male twins (83 MZ twin pairs, 55 DZ twin pairs, and 111 incomplete twin pairs) who were MRI scanned as part of the Vietnam Era Twin Study of Aging...
February 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28223097/the-roles-of-the-orbitofrontal-cortex-via-the-habenula-in-non-reward-and-depression-and-in-the-responses-of-serotonin-and-dopamine-neurons
#7
Edmund T Rolls
Cortical regions such as the orbitofrontal cortex involved in reward and in non-reward and which are implicated in depression, and the amygdala, are connected to the habenula via the striatum and pallidum, and via subcortical limbic structures. The habenula in turn projects to the raphe nuclei, the source of the serotonin-containing neurons that project to the forebrain. It is proposed that this provides a route for cortical signals related to reward, and to not obtaining expected rewards, to influence the serotonin-containing neuronal system that is influenced by many antidepressant treatments...
February 14, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28222792/seroprevalence-of-hepatitis-b-hepatitis-c-human-immunodeficiency-virus-treponema-pallidum-and-co-infections-among-blood-donors-in-kyrgyzstan-a-retrospective-analysis-2013-2015
#8
Bakyt B Karabaev, Nurgul J Beisheeva, Aiganysh B Satybaldieva, Aikul D Ismailova, Frank Pessler, Manas K Akmatov
BACKGROUND: Post-Soviet Kyrgyzstan has experienced a major surge in blood-borne infections, but data from adequately powered, up-to-date studies are lacking. We thus examined a) the seroprevalences of hepatitis B virus surface antigen (HBsAg), HIV-1 p24 antigen and antibodies against hepatitis C virus (anti-HCV), human immunodeficiency viruses (anti-HIV-1/2, HIV-1 group O), and Treponema pallidum among blood donors in Kyrgyzstan and assess their distribution according to sex, age, and provinces of residence; b) trends in the respective seroprevalences; and c) co-infection rates among the pathogens studied...
February 21, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28220718/the-big-imitator-strikes-again-a-case-report-of-neurosyphilis-in-a-patient-with-newly-diagnosed-hiv
#9
Sévérine de Bruijn, Chris Kenyon, Nicolas Léonard, Erika Vlieghe
BACKGROUND: Neurosyphilis is the result of an infection of the central nervous system caused by the spirochete Treponema pallidum. Its clinical presentation includes meningovascular syphilis, tabes dorsalis, and dementia paralytica, resulting in a wide range of symptoms such as psychosis, Parkinsonism, and depression. CASE REPORT: A 49-year-old male was admitted to a psychiatric hospital because of social withdrawal and self-neglect, indicative of a major depression...
February 21, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28219628/subcortical-brain-volume-differences-in-participants-with-attention-deficit-hyperactivity-disorder-in-children-and-adults-a-cross-sectional-mega-analysis
#10
Martine Hoogman, Janita Bralten, Derrek P Hibar, Maarten Mennes, Marcel P Zwiers, Lizanne S J Schweren, Kimm J E van Hulzen, Sarah E Medland, Elena Shumskaya, Neda Jahanshad, Patrick de Zeeuw, Eszter Szekely, Gustavo Sudre, Thomas Wolfers, Alberdingk M H Onnink, Janneke T Dammers, Jeanette C Mostert, Yolanda Vives-Gilabert, Gregor Kohls, Eileen Oberwelland, Jochen Seitz, Martin Schulte-Rüther, Sara Ambrosino, Alysa E Doyle, Marie F Høvik, Margaretha Dramsdahl, Leanne Tamm, Theo G M van Erp, Anders Dale, Andrew Schork, Annette Conzelmann, Kathrin Zierhut, Ramona Baur, Hazel McCarthy, Yuliya N Yoncheva, Ana Cubillo, Kaylita Chantiluke, Mitul A Mehta, Yannis Paloyelis, Sarah Hohmann, Sarah Baumeister, Ivanei Bramati, Paulo Mattos, Fernanda Tovar-Moll, Pamela Douglas, Tobias Banaschewski, Daniel Brandeis, Jonna Kuntsi, Philip Asherson, Katya Rubia, Clare Kelly, Adriana Di Martino, Michael P Milham, Francisco X Castellanos, Thomas Frodl, Mariam Zentis, Klaus-Peter Lesch, Andreas Reif, Paul Pauli, Terry L Jernigan, Jan Haavik, Kerstin J Plessen, Astri J Lundervold, Kenneth Hugdahl, Larry J Seidman, Joseph Biederman, Nanda Rommelse, Dirk J Heslenfeld, Catharina A Hartman, Pieter J Hoekstra, Jaap Oosterlaan, Georg von Polier, Kerstin Konrad, Oscar Vilarroya, Josep Antoni Ramos-Quiroga, Joan Carles Soliva, Sarah Durston, Jan K Buitelaar, Stephen V Faraone, Philip Shaw, Paul M Thompson, Barbara Franke
BACKGROUND: Neuroimaging studies have shown structural alterations in several brain regions in children and adults with attention deficit hyperactivity disorder (ADHD). Through the formation of the international ENIGMA ADHD Working Group, we aimed to address weaknesses of previous imaging studies and meta-analyses, namely inadequate sample size and methodological heterogeneity. We aimed to investigate whether there are structural differences in children and adults with ADHD compared with those without this diagnosis...
February 16, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28216574/an-in-silico-identification-of-common-putative-vaccine-candidates-against-treponema-pallidum-a-reverse-vaccinology-and-subtractive-genomics-based-approach
#11
Arun Kumar Jaiswal, Sandeep Tiwari, Syed Babar Jamal, Debmalya Barh, Vasco Azevedo, Siomar C Soares
Sexually transmitted infections (STIs) are caused by a wide variety of bacteria, viruses, and parasites that are transmitted from one person to another primarily by vaginal, anal, or oral sexual contact. Syphilis is a serious disease caused by a sexually transmitted infection. Syphilis is caused by the bacterium Treponema pallidum subspecies pallidum. Treponema pallidum (T. pallidum) is a motile, gram-negative spirochete, which can be transmitted both sexually and from mother to child, and can invade virtually any organ or structure in the human body...
February 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28168761/functional-clues-from-the-crystal-structure-of-an-orphan-periplasmic-ligand-binding-protein-from-treponema-pallidum
#12
Chad A Brautigam, Ranjit K Deka, Wei Z Liu, Diana R Tomchick, Michael V Norgard
The spirochete Treponema pallidum is the causative agent of syphilis, a sexually transmitted infection of major global importance. Other closely related subspecies of Treponema also are the etiological agents of the endemic treponematoses, such as yaws, pinta, and bejel. The inability of T. pallidum and its close relatives to be cultured in vitro has prompted efforts to characterize T. pallidum's proteins structurally and biophysically, particularly those potentially relevant to treponemal membrane biology, with the goal of possibly revealing the functions of those proteins...
February 7, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28161356/a-retrospective-cross-sectional-quantitative-molecular-approach-in-biological-samples-from-patients-with-syphilis
#13
Miguel Pinto, Minia Antelo, Rita Ferreira, Jacinta Azevedo, Irene Santo, Maria José Borrego, João Paulo Gomes
Syphilis is the sexually transmitted disease caused by Treponema pallidum, a pathogen highly adapted to the human host. As a multistage disease, syphilis presents distinct clinical manifestations that pose different implications for diagnosis. Nevertheless, the inherent factors leading to diverse disease progressions are still unknown. We aimed to assess the association between treponemal loads and dissimilar disease outcomes, to better understand syphilis. We retrospectively analyzed 309 DNA samples distinct anatomic sites associated with particular syphilis manifestations...
March 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28145405/a-defined-syphilis-vaccine-candidate-inhibits-dissemination-of-treponema-pallidum-subspecies-pallidum
#14
Karen V Lithgow, Rebecca Hof, Charmaine Wetherell, Drew Phillips, Simon Houston, Caroline E Cameron
Syphilis is a prominent disease in low- and middle-income countries, and a re-emerging public health threat in high-income countries. Syphilis elimination will require development of an effective vaccine that has thus far remained elusive. Here we assess the vaccine potential of Tp0751, a vascular adhesin from the causative agent of syphilis, Treponema pallidum subsp. pallidum. Tp0751-immunized animals exhibit a significantly reduced bacterial organ burden upon T. pallidum challenge compared with unimmunized animals...
February 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28126263/treponema-pallidum-flagellins-elicit-proinflammatory-cytokines-from-human-monocytes-via-tlr5-signaling-pathway
#15
Man Xu, Yafeng Xie, Chuanhao Jiang, Yongjian Xiao, Xingxing Kuang, Yating Wen, Yuan Tan, Manyi Tan, Feijun Zhao, Tiebing Zeng, Yimou Wu
The tissue damage caused by syphilis infection may be associated with inflammation. However, the virulence factors of Treponema pallidum are still unclear, nor are the molecular mechanisms for leading to the productions of proinflammatory cytokines. Flagellin, a classic pathogen-associated molecular pattern (PAMP), is a potent immunogen that induces inflammation. In the present study, we have demonstrated that stimulations of human monocytes with Treponema pallidum FlaB1, FlaB2, and FlaB3 result in the up regulation of interleukin (IL)-6 and IL-8...
January 21, 2017: Immunobiology
https://www.readbyqxmd.com/read/28122879/18f-av-1451-positron-emission-tomography-in-alzheimer-s-disease-and-progressive-supranuclear-palsy
#16
Luca Passamonti, Patricia Vázquez Rodríguez, Young T Hong, Kieren S J Allinson, David Williamson, Robin J Borchert, Saber Sami, Thomas E Cope, W Richard Bevan-Jones, P Simon Jones, Robert Arnold, Ajenthan Surendranathan, Elijah Mak, Li Su, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Rowe
The ability to assess the distribution and extent of tau pathology in Alzheimer's disease and progressive supranuclear palsy in vivo would help to develop biomarkers for these tauopathies and clinical trials of disease-modifying therapies. New radioligands for positron emission tomography have generated considerable interest, and controversy, in their potential as tau biomarkers. We assessed the radiotracer (18)F-AV-1451 with positron emission tomography imaging to compare the distribution and intensity of tau pathology in 15 patients with Alzheimer's pathology (including amyloid-positive mild cognitive impairment), 19 patients with progressive supranuclear palsy, and 13 age- and sex-matched controls...
January 24, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28093460/a-double-edged-sword-does-highly-active-antiretroviral-therapy-contribute-to-syphilis-incidence-by-impairing-immunity-to-treponema-pallidum
#17
REVIEW
Michael L Rekart, Wilfred Ndifon, Robert C Brunham, Jonathan Dushoff, Sang Woo Park, Sanjana Rawat, Caroline E Cameron
BACKGROUND AND HYPOTHESIS: Recently, the world has experienced a rapidly escalating outbreak of infectious syphilis primarily affecting men who have sex with men (MSM); many are taking highly active antiretroviral therapy (HAART) for HIV-1 infection. The prevailing hypothesis is that HAART availability and effectiveness have led to the perception among both individuals who are HIV-1 infected and those who are uninfected that HIV-1 transmission has become much less likely, and the effects of HIV-1 infection less deadly...
January 16, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28079920/serum-microrna-profiles-in-patients-with-syphilis
#18
Ping Lu, Chang Fang, Qing Cheng, Wu-Jian Ke, Tao Huang, Jun Zhang, He-Ping Zheng, Bin Yang
Syphilis is an acute and chronic inflammatory disorder caused by the non-cultivatable spirochete Treponema pallidum subsp. pallidum (T. pallidum).(1,2) T. pallidum does not produce any known toxic proteins; therefore, most of the symptoms and tissue damage related to syphilis are caused by activation of the host's inflammatory and immune responses,(3) thus suggesting that host genetics play an important role in regulating the progression of syphilis infection. MiRNAs are a class of 19- to 24-nt noncoding RNAs that influence many biological systems, including development, cellular differentiation, proliferation, apoptosis, metabolism, and the immune response;(4-6) they also play crucial roles during microbial infection...
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28019101/subtypes-and-risk-behaviors-among-incident-hiv-cases-in-the-bangkok-men-who-have-sex-with-men-cohort-study-thailand-2006-2014
#19
Caitlin R Lam, Timothy H Holtz, Wanna Leelawiwat, Philip A Mock, Wannee Chonwattana, Wipas Wimonsate, Anchalee Varangrat, Warunee Thienkrua, Charles Rose, Anupong Chitwarakorn, Marcel E Curlin
HIV-1 incidence and prevalence remain high among men who have sex with men (MSM), and transgender women (TGW), in Thailand. To examine the link between epidemiologic factors and HIV-1 subtype transmission among Thai MSM, we compared covariates of infection with HIV CRF01_AE and other HIV strains among participants in the Bangkok MSM Cohort Study (BMCS). The BMCS was an observational cohort study of Thai MSM and TGW with up to 60 months of follow-up at 4 monthly intervals. Participants underwent HIV/sexually transmitted infections testing and provided behavioral data at each visit...
January 27, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28009086/1-2-diacylglycerol-choline-phosphotransferase-catalyzes-the-final-step-in-the-unique-treponema-denticola-phosphatidylcholine-biosynthesis-pathway
#20
Miguel Ángel Vences-Guzmán, M Paula Goetting-Minesky, Ziqiang Guan, Santiago Castillo-Ramirez, Luz América Córdoba-Castro, Isabel M López-Lara, Otto Geiger, Christian Sohlenkamp, J Christopher Fenno
Treponema denticola synthesizes phosphatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Treponema. However, the mechanism of conversion of CDP-choline to phosphatidylcholine remained unclear. We report here characterization of TDE0021 (herein designated cpt) encoding a 1,2-diacylglycerol choline phosphotransferase homologous to choline phosphotransferases that catalyze the final step of the highly conserved Kennedy pathway for phosphatidylcholine synthesis in eukaryotes...
December 23, 2016: Molecular Microbiology
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