Na Li, Yanli Li, Ting Yu, Mengzhuang Gou, Wenjin Chen, Xiaoying Wang, Jinghui Tong, Song Chen, Shuping Tan, Zhiren Wang, Baopeng Tian, Chiang-Shan R Li, Yunlong Tan
Schizophrenia patients with tardive dyskinesia (TD) are associated with accelerated biological aging, immunological dysfunction, and premature morbidity and mortality. Older individuals are particularly vulnerable to TD development. As a characteristic of immunosenescence, alterations in the relative proportions of naïve or memory T cell subpopulations may be negatively or positively associated with brain structure abnormalities; however, whether these changes are correlated with TD remains unclear. In this study, we investigated correlations between distributions of T cell phenotypes and brain structure abnormalities (especially white matter) in schizophrenia patients with (TD) and without (NTD) TD (n = 50 and 58, respectively) relative to healthy controls (HC, n = 41)...
May 8, 2024: Schizophrenia Research