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Katja Zerbe, Kerstin Moehle, John A Robinson
Protein epitope mimetics provide powerful tools to study biomolecular recognition in many areas of chemical biology. They may also provide access to new biologically active molecules and potentially to new classes of drug and vaccine candidates. Here we highlight approaches for the design of folded, structurally defined epitope mimetics, by incorporating backbone and side chains of hot residues onto a stable constrained scaffold. Using robust synthetic methods, the structural, biological, and physical properties of epitope mimetics can be optimized, by variation of both side chain and backbone chemistry...
June 1, 2017: Accounts of Chemical Research
János Sinkó
Invasive fungal diseases represent an ever changing field within infectology, profoundly affecting daily clinical activities of specialists in haematology. The dynamic development seen in oncohaematology creates novel risk groups of patients, consequently necessitating a re-evaluation of principles in antifungal therapy from time to time. Not even in 2017 may achievements of fungal diagnostics and therapy become a substitute for clinical thinking and adaptation of general guidelines according to local experience...
March 8, 2017: Magyar Onkologia
A Anula-Morales, B Martin-Giner, M Hernández-Cabrera, C Carranza-Rodríguez, E Pisos-Álamo, N Jaén-Sánchez, J L Pérez-Arellano
OBJECTIVE: The aim was to analyse those syndromes without fever in travellers who return from tropical regions evaluated at our Department of Infectology and Tropical Medicine. Clarifying these conditions intends to reach earlier diagnoses and, perhaps, to avoid the emergence and spread of imported diseases, as well as to establish appropriate preventive measures. METHODS: An observational descriptive transversal study was performed, selecting those patients who returned from tropical regions without fever (n = 281), amongst all travellers evaluated in our department between 1998 and 2013...
April 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Miguel Guzmán
No abstract text is available yet for this article.
April 19, 2016: Biomédica: Revista del Instituto Nacional de Salud
Paul Franz, Heike Betat, Mario Mörl
BACKGROUND: To allow an immediate treatment of an infection with suitable antibiotics and bactericides or fungicides, there is an urgent need for fast and precise identification of the causative human pathogens. Methods based on DNA sequence comparison like 16S rRNA analysis have become standard tools for pathogen verification. However, the distinction of closely related organisms remains a challenging task. To overcome such limitations, we identified a new genomic target sequence located in the single copy gene for tRNA nucleotidyltransferase fulfilling the requirements for a ubiquitous, yet highly specific DNA marker...
March 18, 2016: BMC Microbiology
Carolina Arias Arias, Maria Carolina Tamayo Betancur, Miguel Alejandro Pinzón, Doris Cardona Arango, Cesar Antonio Capataz Taffur, Edgar Correa Prada
Osteomyelitis is a heterogeneous infection with regard to etiology and treatment, and currently no single management protocol exists. Management of the condition is typically an interdisciplinary approach between orthopedics and infectious disease; however, the orthopedist is often the person who manages treatment. The aim of the study was to determine differences in the outcome of osteomyelitis according to its treating specialty and to identify factors associated with the recurrence of the disease. An ambispective cohort study of 129 patients with osteomyelitis was conducted and the proportions for qualitative variables and central tendency and dispersion measures for quantitative variables were calculated; the latter were tested for normality using the Shapiro-Wilk test...
2015: PloS One
Marcelo Corti
In this review, the intention is to present the four clinical models of HIV-1-brain damage, named with the diffuse category of HIV-encephalopathy. It contains the past three decades, since the first static-infectological model of Snider WD, developed in 1983, based in a great neuropathological trial with AIDS patients. The second one, maybe the most compact of them, was the AIDS-dementia complex, published by the Navia BA group, in two notable papers published in 1986. This resulted in a consistent HIV-neuropsychiatric condition, till 1996, when HAART era begun...
May 2015: Vertex: Revista Argentina de Psiquiatriá
N Sarsekeyeva, B Kosherova, N Tabagari-Bregvadze
At present, an infection caused by the hepatitis C virus is common among HIV-infected patients. The rapid growth of drug addiction, sexual route of infection transmission, HIV and HCV infection among young people, low efficiency of treatment and lack of specific means of prevention clearly means that this pathology is to be listed among the first in the modern infectology. The aim of the study was to investigate the characteristics of the course of chronic hepatitis C in HIV-infected patients, depending on the route of infection...
October 2015: Georgian Medical News
Rosa Polo Rodriguez, Fernando Lozano, Pedro González de Castro, Ma Alonso Jiménez, Oscar Miró, Jose Ramón Blanco, David Moreno, Carlos Dueñas, Enriqueta Muñoz Platón, Marina Fernández Escribano, Jesús Sanz Sanz, Carmina Fumaz, Ignacio Santos, Federico García, Ma Jesús Téllez, Raúl González Montero, Ma Victoria Vals Jimenez, Juan Emilio Losa, Ma Luisa Valle Robles, Jose Antonio Iribarren, Enrique Ortega
Post-exposure prophylaxis (PEP) can be a secondary measure to prevent infection by human immunodeficiency virus (HIV) when primary prevention has failed. PEP is advised for people with sporadic and exceptional risk exposure to HIV. This consensus document about occupational and non-occupational PEP recommendations aims to be a technical document for healthcare professionals. Its main objective is to facilitate the appropriate use of PEP. To this end, some recommendations have been established to assess the risk of transmission in different types of exposure, situations where PEP should be recommended, special circumstances to take into account, antiretroviral (ARV) guidelines including start and end of the treatment, early monitoring of tolerance and adherence to the treatment, subsequent monitoring of people exposed, independently of having received PEP or not, and need of psychological support...
February 2016: Enfermedades Infecciosas y Microbiología Clínica
Bruno Bonnemain
At the beginning of the 1910's period, several scientists and pharmaceutical companies are working actively on colloids, which were discovered in 1845. The pharmaceutical use of"electrical colloids" was the subject of publications and researches for a therapeutic usage, mainly in infectology and oncology. One hun- dred years later, it is under the name ofnanoparticles that the same subject comes to light-and is the source of new works for a potential use for cancer treatment. The example of selenium, which was introduced under a colloidal form in medicine in 1912, is studied here, but other metals could have given the same result: metallic nanoparticles evaluation in pharmacy is not new!...
January 2014: Revue D'histoire de la Pharmacie
Gabor Gazdag, Zsuzsa Szabo, Janos Szlavik
It is essential for the psychiatrist working in the consultation-liaison field or with comorbid patients to be familiar with the psychiatric aspects of central nervous infectious diseases or infectious diseases with psychiatric symptoms. Authors have reviewed the most important psychiatric aspects of common infectious diseases. Essential knowledge for setting up a diagnosis and starting appropriate treatment has been summarized. The most important interactions of infectological and psychiatric treatments have also been discussed...
December 2014: Neuropsychopharmacologia Hungarica
N N Kostiukova, V A Bekhalo
Owing to rapid development of molecular-biological and genetic methods of research in infectology as well as use of adequate models (tissue colonization of human respiratory epithelium, mice models of colonization, sepsis and meningitis), a significant progress in the field of pneumococcus pathogenicity factors has been made in the last decades. Aside from the well-known pathogenicity factor--capsule polysaccharide, to date several dozens of surface proteins providing adhesion, colonization and invasion have been detected in pneumococcus...
May 2014: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Alfredo Prado, Nhora L Arias, Mónica Chávez, Cristina E Cabrera, Romel F Gómez
INTRODUCTION: Phenotypic characterization of the Acinetobacter genus bacteria through biochemical and microscopic tests is possible. Studies have shown that the isolates from health-care associated infections show high resistance to first-line antibiotics. OBJECTIVE: To describe the resistance patterns of the A. baumannii isolates obtained in a health care institution, the phenotypic characteristics of the isolates, and the possible resistance mechanisms. MATERIALS AND METHODS: A descriptive cross-sectional study was conducted with 28 reports of samples taken from patients hospitalized with infection by A...
April 2014: Biomédica: Revista del Instituto Nacional de Salud
Miguel A Guzmán
No abstract text is available yet for this article.
April 2014: Biomédica: Revista del Instituto Nacional de Salud
L Balke, A Günther, R Zeuner, B Bewig
Eosinophilia presents a challenge to differential diagnostics due to the multitude of possible causes. An initial difficulty is often to distinguish between threatening disease symptoms and relatively harmless secondary reactions. A highly dynamic clinical progression with severe impairment of the vital functions, like breathing, for example, can make swift action necessary. An example of this is known as acute eosinophile pneumonia, which can often only be controlled with the rapid use of high steroid doses...
May 2014: Deutsche Medizinische Wochenschrift
V F Uchaĭkin, O V Shamsheva
In this article a concept of infectious disease pathogenesis as consisted with clinical symptoms is provided. The course of disease, immediate and long-term consequences depend on the mode of entry. If the infection comes via oropharynx, airway, gastrointestinal tract or via skin, the immune system provides adequate immune response. This leads to typical symptoms, cyclical clinic progression and usually to the recovery with the formation of full sterile immunity. In case of parenteral way of infection, which includes perinatal way, there is no full mode of entry, the disease takes chronic course involving visceral organs because of different mechanisms of affinity and new tropic organ involving...
2013: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Iu V Lobzin, K V Zhdanov
Russian first department of infectious diseases, which has great traditions and achievements, as of right is a brilliant constellation of national researchers and practitioners military infectology, not only brought the Kirov Military Medical Academy into repute, but also made a huge contribution to the development of the science of infectious diseases and the establishment of an effective system treatment and prevention of these diseases. This article outlines the main historical stages of infectology in the armed forces of our country, summed up the contribution of members of the Department of Infectious Diseases of the Military Medical Academy in medical science, marked modern progress and prospects of development of military infectology...
December 2013: Voenno-medit︠s︡inskiĭ Zhurnal
Izet Masic, Nada Koluder-Cimic, Sead Ahmetagic, Rusmir Baljic
The 4th Congress of Infectiologists of Bosnia-Herzegovina with international participation was held in Konjic, on 30. May to 02. June 2012. In addition to the prominent infectious disease experts from almost all university centers in B&H, the teachers at medical schools in Bosnia-Herzegovina, infectious disease specialists who work in health institutions in B&H, this Congress was attended by infectious disease experts from Serbia (12 participants), Turkey (3 participants), Croatia (3 participants), Macedonia (3 participants), Germany (2 participants) and Montenegro (2 participants)...
2012: Materia Socio-medica
Nada Koluder-Cimic, Izet Masic
none declared There is a relatively low amount of historical data about development of infectology in Bosnia and Herzegovina, but that does not mean that these medical disciplines didn't have important events and actors that are important for the development of this medical discipline in B&H. In this review we intent to show your several characteristic events and important persons, which left a lasting impression in the development of infectology service in BIH and especially in Sarajevo. Development center for this discipline was in Sarajevo...
2012: Materia Socio-medica
K Chakalaroski
The chair of internal medicine in Republic of Macedonia was created in 1947. The Department of Internal Medicine (CIM) is the most numerous at Skopje's medical faculty (currently 56 members). According to the archive material from the first session of the Scientific Teaching Council of the Faculty of Medicine (17.03.1947), Mr Mario Krmpotic (Professor of Internal Medicine) was proposed as the first Director of the Internal Clinic (1947). For reasons unknown, Mr Krmpotic never came to Skopje to accept the post...
2013: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
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