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Idoia Arrizabalaga Aldalur, Beatriz García Martinez, Shahrazad Benabdellah Abouhammadi, María Del Carmen García Tirado, Alfredo Pardo Cabello, Pilar Parra Rosado
No abstract text is available yet for this article.
October 1, 2016: Revista Española de Geriatría y Gerontología
Arjun Poudel, Nancye M Peel, Lisa M Nissen, Charles A Mitchell, Leonard C Gray, Ruth E Hubbard
OBJECTIVE: To explore the relationship between polypharmacy and adverse outcomes among older hospital inpatients stratified according to their frailty status. DESIGN AND SETTING: A prospective study of 1418 patients, aged 70 and older, admitted to 11 hospitals across Australia. MEASUREMENTS: The interRAI Acute Care (AC) assessment tool was used for all data collection, including the derivation of a frailty index calculated using the deficit accumulation method...
August 1, 2016: Journal of the American Medical Directors Association
Jason A Gregg, Ronald L Tyson, Donna Cook
In the elderly, Potentially Inappropriate Prescriptions (PIPs) are quite common and connected with adverse drug events (ADEs), hospital stays, increased medical acuities, and inefficacious healthcare. Benzodiazepines as a class have been identified as an independent risk factor for ADE's and shown to be associated with sedation and impairments in cognition, memory, and balance, lending to an increased risk for falls. Clinically inappropriate medications continue to be prescribed and preferred by many clinicians over non-pharmacological strategies despite continued evidence demonstrating poor outcomes in older adults...
September 2016: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
Jennifer Zelmer
No abstract text is available yet for this article.
February 2016: Healthcare Policy, Politiques de Santé
Emily Reeve, Danijela Gnjidic, Janet Long, Sarah Hilmer
AIMS: The aim of this study was to identify what definitions have been published for the term 'deprescribing', and determine whether a unifying definition could be reached. A secondary aim was to uncover patterns between the published definitions which could explain any variation. METHODS: Systematic literature searches were performed (earliest records to February 2014) in MEDLINE, Embase, CINAHL, Informit, Scopus and Google Scholar. The terms deprescrib* or de-prescrib* were employed as a keyword search in all fields...
December 2015: British Journal of Clinical Pharmacology
Amit S Mutha, Vijay R Kulkarni, Sagar B Bhagat, Amit S Beldar, Sadiq B Patel
INTRODUCTION: Erectile dysfunction (ED) is a common occurrence and its incidence is expected to increase significantly along with the increase in various lifestyle diseases. The drug utilization for ED is very low. Also, studies describing the prescription pattern in ED are lacking. MATERIALS AND METHODS: We conducted a retrospective cross-sectional observational study, including a drug utilization analysis, of 606 prescriptions as per the standard guidelines (WHO and STROBE)...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
José Fernando de Macedo, Gustavo Capinzaiki de Macedo, Luciana Aparecida Campos, Ovidiu Constantin Baltatu
Patients with systemic lupus erythematosus have a poor prognosis of pregnancy, since it is associated with significant maternal and fetal morbidity, including spontaneous miscarriage, pre-eclampsia, intrauterine growth restriction, fetal death and pre-term delivery. We report a case with successful pregnancy in a patient with systemic lupus erythematosus and hypertension. A 39-year-old nulliparous woman presented with systemic lupus erythematosus with antinuclear and antiphospholipid antibodies, hypertension and recurrent pregnancy loss presented for assisted reproduction...
September 2015: Medicine (Baltimore)
Juliana Garcia, Vera M Costa, Alexandra Carvalho, Paula Baptista, Paula Guedes de Pinho, Maria de Lourdes Bastos, Félix Carvalho
Amanita phalloides, also known as 'death cap', is one of the most poisonous mushrooms, being involved in the majority of human fatal cases of mushroom poisoning worldwide. This species contains three main groups of toxins: amatoxins, phallotoxins, and virotoxins. From these, amatoxins, especially α-amanitin, are the main responsible for the toxic effects in humans. It is recognized that α-amanitin inhibits RNA polymerase II, causing protein deficit and ultimately cell death, although other mechanisms are thought to be involved...
December 2015: Food and Chemical Toxicology
Jenny Fairthorne, Geoff Hammond, Jenny Bourke, Nick de Klerk, Helen Leonard
Psychiatric disorders are more common in the mothers of children with autism spectrum disorder (ASD) or intellectual disability (ID) after the birth of their child. We aimed to assess the relationship between women's psychiatric contacts and subsequent offspring with ASD/ID. We linked three Western Australian registers to investigate pre-existing maternal outpatient psychiatric contacts and the odds of ASD/ID in a subsequent child. Women with a previous outpatient psychiatric contact were more than twice as likely to have a child with ASD [OR 2...
February 2016: Journal of Autism and Developmental Disorders
S Terraneo, M Ferrer, I Martín-Loeches, M Esperatti, M Di Pasquale, V Giunta, M Rinaudo, F de Rosa, G Li Bassi, S Centanni, A Torres
In immunocompetent patients with nosocomial pneumonia, the relationship between Candida spp. isolation in respiratory samples and outcomes or association with other pathogens is controversial. We therefore compared the characteristics and outcomes of patients with intensive care unit-acquired pneumonia (ICUAP), with or without Candida spp. isolation in the respiratory tract. In this prospective non-interventional study, we assessed 385 consecutive immunocompetent patients with ICUAP, according to the presence or absence of Candida spp...
January 2016: Clinical Microbiology and Infection
Marine Delobeau, Ahlam Abdou, Eve Puzenat, Elise Deveza, Caroline Biver-Dalle, Alison van de Laak, Blandine Roche-Kubler, Lucine Vuitton, Stéphane Koch, Daniel Wendling, François Aubin
INTRODUCTION: Although the efficacy of TNF blockers has been demonstrated in hidradenitis suppurativa (HS), many paradoxical effects have also been described with TNF antagonists. We wished to describe patients with adalimumab (ADA)-induced paradoxical HS. METHODS: This is a retrospective descriptive case series of four patients with ADA-induced paradoxical HS. RESULTS: All the patients had a good response to TNFa antagonist therapy at the time of HS occurrence...
2016: Journal of Dermatological Treatment
D Barberena, G Gatti, F De Zela
We present a simple device that works as a secondary source of light with prescribed polarization properties. The device has great versatility, allowing complete control over both the degree of polarization and the Stokes vector that belongs to the fully polarized component of partially polarized light beams. We report experimental results that illustrate the device's versatility, by showing how polarized states can be moved within the Poincaré ball along spiraling paths.
April 1, 2015: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Roi Piñeiro Pérez, Begoña Santiago García, Cecilia M Fernández Llamazares, Fernando Baquero Artigao, Antoni Noguera Julian, María José Mellado Peña
INTRODUCTION: There are no paediatric formulations of anti-tuberculous drugs in Spain, with the only exception being rifampicin. Some paediatricians often prescribe composite formulations (CF), while others prefer to give crushed tablets. Nevertheless, there is no consensus in this regard, or any pharmacokinetic studies validating these procedures. In this situation, the Spanish Network for the Study of Paediatric Tuberculosis (pTBred) has launched the Magistral Project, which has as its first phase aims to analyse the desirability of developing child-friendly pharmaceutical formulations and other aspects regarding the anti-tuberculous drug prescription in children...
July 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Delphine Berthod, Blaise Genton, Christoph Hatz, Johannes Blum, Serge de Vallière
BACKGROUND: Fever is a frequent cause of medical consultation among returning travelers. The objectives of this study were to assess whether physicians were able to identify patients with influenza and whether the use of an influenza rapid diagnostic test (iRDT) modified the clinical management of such patients. METHODS: Randomized controlled trial conducted at 2 different Swiss hospitals between December 2008 and November 2012. Inclusion criteria were 1) age ≥ 18 years, 2) documented fever of ≥ 38 °C or anamnestic fever + cough or sore throat within the last 4 days, 3) illness occurring within 14 days after returning from a trip abroad, 4) no definitive alternative diagnosis...
September 2015: Travel Medicine and Infectious Disease
Martin Heine, Ingrid van de Port, Marc B Rietberg, Erwin E H van Wegen, Gert Kwakkel
BACKGROUND: Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system affecting an estimated 1.3 million people worldwide. It is characterised by a variety of disabling symptoms of which excessive fatigue is the most frequent. Fatigue is often reported as the most invalidating symptom in people with MS. Various mechanisms directly and indirectly related to the disease and physical inactivity have been proposed to contribute to the degree of fatigue. Exercise therapy can induce physiological and psychological changes that may counter these mechanisms and reduce fatigue in MS...
2015: Cochrane Database of Systematic Reviews
Stefanie N Hofstede, Thea P M Vliet Vlieland, Cornelia H M van den Ende, Rob G H H Nelissen, Perla J Marang-van de Mheen, Leti van Bodegom-Vos
OBJECTIVES: National and international evidence-based guidelines for hip and knee osteoarthritis (OA) recommend to start with non-surgical treatments, followed by surgical intervention if a patient does not respond sufficiently to non-surgical treatments, but there are indications that these are not optimally used. The aim of this study was to assess the extent to which all recommended non-surgical treatments were used by patients with hip or knee OA who receive(d) a total hip or knee replacement, as reported by patients and orthopaedic surgeons...
2015: BMJ Open
Arlete Rita Penitente, Ana Luísa Junqueira Leite, Guilherme de Paula Costa, Deena Shrestha, Aline Luciano Horta, Antônio J Natali, Clóvis A Neves, Andre Talvani
The protozoan Trypanosoma cruzi triggers an inflammatory process in mammalian heart causing events such as fibrosis, changes in the architecture and functionality in this organ. Enalapril, an angiotensin II-converting enzyme inhibitor, is a drug prescribed to ameliorate this heart dysfunction, and appears to exert a potential role in immune system regulation. Our aim was to evaluate the chronic cardiac inflammatory parameters after therapeutic treatment with enalapril and benznidazole in C57BL/6 mice infected with the VL-10 strain of T...
November 2015: American Journal of Tropical Medicine and Hygiene
Amir Akbari, Reghan J Hill, Theo G M van de Ven
An elastocapillary model for drying-induced collapse is proposed. We consider a circular elastic membrane with a hole at the centre that is deformed by the capillary pressure of simply and doubly connected menisci. The membrane overlays a cylindrical cavity with rigid walls, trapping a prescribed volume of water. This geometry may be suitable for studying structural failures and stiction in micro-electromechanical systems during wet etching, where capillary surfaces experience catastrophic transitions. The dry state is determined using the dihedral-angle and volume-turning-point stability criteria...
July 8, 2015: Proceedings. Mathematical, Physical, and Engineering Sciences
Candice Estellat, Florence Tubach, Raphaèle Seror, Toni Alfaiate, David Hajage, Yann De Rycke, Philippe Ravaud
OBJECTIVES: Control treatments in randomized controlled trials (RCTs) should not deliberately disadvantage patients. The objectives of the study were to compare (1) willingness to include vs. (2) willingness to prescribe control treatment among physicians randomized to assess, respectively, either (1) enrollment in a trial or (2) appropriateness of control treatment in a care context for the same fictional patient. STUDY DESIGN AND SETTING: Physicians were authors of articles about rheumatoid arthritis (RA), involved in RA patient care, and used to enrolling patients in trials...
January 2016: Journal of Clinical Epidemiology
P David Halevi, Fernando Ramirez-de-Noriega, Yakov Fellig, J Moshe Gomori, José E Cohen, Eyal Itshayek
BACKGROUND CONTEXT: Pleomorphic liposarcoma (PLS) is a rare malignant soft tissue tumor comprising 5%-15% of liposarcomas and characterized by high malignant potential. To our knowledge only three cases of this entity have been reported in the spine. PURPOSE: We describe the only reported case of a purely epidural PLS with no macroscopic bone involvement at diagnosis. STUDY DESIGN/SETTING: A case presenting clinical evidence that PLS may arise from the epidural fat is reported...
December 1, 2015: Spine Journal: Official Journal of the North American Spine Society
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