Garabed Eknoyan, Gerald J Beck, Alfred K Cheung, John T Daugirdas, Tom Greene, John W Kusek, Michael Allon, James Bailey, James A Delmez, Thomas A Depner, Johanna T Dwyer, Andrew S Levey, Nathan W Levin, Edgar Milford, Daniel B Ornt, Michael V Rocco, Gerald Schulman, Steve J Schwab, Brendan P Teehan, Robert Toto
BACKGROUND: The effects of the dose of dialysis and the level of flux of the dialyzer membrane on mortality and morbidity among patients undergoing maintenance hemodialysis are uncertain. METHODS: We undertook a randomized clinical trial in 1846 patients undergoing thrice-weekly dialysis, using a two-by-two factorial design to assign patients randomly to a standard or high dose of dialysis and to a low-flux or high-flux dialyzer. RESULTS: In the standard-dose group, the mean (+/-SD) urea-reduction ratio was 66...
December 19, 2002: New England Journal of Medicine