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https://www.readbyqxmd.com/read/28107119/olfaction-new-understandings-diagnostic-applications
#1
Gabrielle F Ruggiero, Jeannette Y Wick
Estimates indicate that 14 million Americans have olfactory dysfunction. As with other senses, such as sight and hearing, olfaction frequently declines with age. Impaired olfaction can be a warning sign of Parkinson's disease, sometimes occurring before motor symptoms develop. It's also an initial symptom of Alzheimer's dementia (AD); the amyloid plaques and tangles characterizing AD invade the olfactory bulb and hippocampus early in its course, hampering odor identification. Olfactory dysfunction is associated with some serious problems, including inability to smell warning odors (fire, gas) and impaired ability to taste food...
November 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28103755/what-makes-a-better-smeller
#2
Asifa Majid, Laura Speed, Ilja Croijmans, Artin Arshamian
Olfaction is often viewed as difficult, yet the empirical evidence suggests a different picture. A closer look shows people around the world differ in their ability to detect, discriminate, and name odors. This gives rise to the question of what influences our ability to smell. Instead of focusing on olfactory deficiencies, this review presents a positive perspective by focusing on factors that make someone a better smeller. We consider three driving forces in improving olfactory ability: one's biological makeup, one's experience, and the environment...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28039314/olfaction-and-risk-of-dementia-in-a-biracial-cohort-of-older-adults
#3
Kristine Yaffe, Daniel Freimer, Honglei Chen, Keiko Asao, Andrea Rosso, Susan Rubin, Greg Tranah, Steve Cummings, Eleanor Simonsick
OBJECTIVE: Prior studies indicate that olfactory function may be an early marker for cognitive impairment, but the body of evidence has been largely restricted to white populations. METHODS: We studied 2,428 community-dwelling black and white older adults (baseline age 70-79 years) without dementia enrolled in the Health, Aging, and Body Composition (Health ABC) study. Olfaction was measured as odor identification (OI) with the 12-item Cross Cultural Smell Identification Test in year 3...
December 30, 2016: Neurology
https://www.readbyqxmd.com/read/28038387/on-the-nose-olfactory-disturbances-in-patients-with-transient-epileptic-amnesia
#4
Sharon A Savage, Christopher R Butler, Fraser Milton, Yang Han, Adam Z Zeman
OBJECTIVE: While olfactory hallucinations are relatively rare in epilepsy, a high prevalence (up to 42%) has been reported in one form - Transient Epileptic Amnesia (TEA). TEA is characterized by recurring amnestic seizures and is commonly associated with persistent interictal memory deficits. Despite reports of changes in smell, olfactory ability has not been objectively assessed in this group. The aim of this study was to measure olfactory ability in patients with TEA and explore whether olfactory symptoms relate to other clinical variables...
December 27, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28007787/factors-associated-with-inaccurate-self-reporting-of-olfactory-dysfunction-in-older-us-adults
#5
Dara R Adams, Kristen E Wroblewski, David W Kern, Michael J Kozloski, William Dale, Martha K McClintock, Jayant M Pinto
Self-reported olfactory function has poor sensitivity (i.e., people with measured olfactory dysfunction are unlikely to accurately report it). We aimed to identify factors associated with lack of awareness of smell dysfunction. Objective odor identification was evaluated using a validated 5-item test in respondents from the National Social Life, Health, and Aging Project, a representative sample of home-dwelling, US adults ages 57-85 (n = 1468). Self-reported olfaction was assessed with a 5-point Likert scale...
December 22, 2016: Chemical Senses
https://www.readbyqxmd.com/read/27868477/association-between-olfaction-and-higher-cortical-functions-in-alzheimer-s-disease-mild-cognitive-impairment-and-healthy-older-adults
#6
Amanda M Ward, Matthew Calamia, Erin Thiemann, Jamie Dunlap, Daniel Tranel
INTRODUCTION: Neural regions important for smell are proximal and closely connected to cortical areas that have been strongly implicated in higher order functions of value-based decision making and emotional memory. The integrity of these neural regions are affected in aging and neurodegenerative conditions. Two specific predictions follow from these neuroanatomical arrangements-namely, that olfaction would be associated with value-based decision making and with emotional memory. METHOD: To test these predictions, we measured these different capacities in participants with presumed varying degrees of integrity of the relevant brain structures: specifically, 13 patients with Alzheimer's disease, 8 patients with mild cognitive impairment, and 20 healthy older adults...
November 20, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27860366/the-effect-of-intranasal-sodium-citrate-on-olfaction-in-post-infectious-loss-results-from-a-prospective-placebo-controlled-trial-in-49-patients
#7
K L Whitcroft, M Ezzat, M Cuevas, P Andrews, T Hummel
OBJECTIVES: Free calcium plays an integral role in peripheral olfactory processing, including feedback inhibition. It has therefore been suggested that reduction of intranasal free calcium with buffer solutions such as sodium citrate may improve olfactory function in patients with smell impairment. Several previous studies have supported this hypothesis, particularly in post-infectious olfactory loss. We therefore aimed to determine whether treatment with intranasal sodium citrate improves olfactory function in patients with post-infectious impairment...
November 10, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27859959/when-preschoolers-follow-their-eyes-and-older-children-follow-their-noses-visuo-olfactory-social-affective-matching-in%C3%A2-childhood
#8
Annachiara Cavazzana, Christiane Wesarg, Julia Parish-Morris, Johan N Lundström, Valentina Parma
Recognition of emotional facial expressions is a crucial skill for adaptive behavior that most often occurs in a multi-sensory context. Affective matching tasks have been used across development to investigate how people integrate facial information with other senses. Given the relative affective strength of olfaction and its relevance in mediating social information since birth, we assessed olfactory-visual matching abilities in a group of 140 children between the ages of 3 and 11 years old. We presented one of three odor primes (rose, fish and no-odor, rated as pleasant or unpleasant by individual children) before a facial choice task (happy vs...
November 17, 2016: Developmental Science
https://www.readbyqxmd.com/read/27849216/olfactory-function-and-quality-of-life-after-olfaction-rehabilitation-in-total-laryngectomees
#9
Christiane Gouvêa Dos Santos, Anke Bergmann, Kaliani Lima Coça, Angela Albuquerque Garcia, Tânia Cristina de Oliveira Valente
Purpose: To evaluate the effects of olfaction rehabilitation in the olfactory function and quality of life of total laryngectomized patients. Methods: Pre-post intervention clinical study conducted with total laryngectomees submitted to olfaction rehabilitation by means of the Nasal Airflow-Inducing Maneuver (NAIM) using the University of Pennsylvania Smell Identification Test (UPSIT), Olfactory Acuity Questionnaires, a Monitoring Questionnaire, and the University of Washington Quality of Life Questionnaire (UW-QOL)...
November 2016: CoDAS
https://www.readbyqxmd.com/read/27830335/olfaction-and-sinonasal-symptoms-in-patients-with-crswnp-and-aerd-and-without-aerd-a-cross-sectional-and-longitudinal-study
#10
V Gudziol, M Michel, C Sonnefeld, D Koschel, T Hummel
Oral aspirin challenge (OAC) reveals aspirin-exacerbated respiratory disease (AERD) in approximately 50% of unselected patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). Smell loss is one factor that predicts the outcome of OAC. The present study aims to unveil differences in olfactory function between patients with CRSwNP with and without AERD by means of a validated reliable test for odor threshold, discrimination and identification. Additionally, Beck Depression Inventory (BDI) and Sinonasal Outcome Test 22 (SNOT 22) were applied...
November 9, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27681497/development-and-validation-of-a-food-associated-olfactory-test-faot
#11
Melanie Yvonne Denzer-Lippmann, Jonathan Beauchamp, Jessica Freiherr, Norbert Thuerauf, Johannes Kornhuber, Andrea Buettner
Olfactory tests are an important tool in human nutritional research for studying food preferences, yet comprehensive tests dedicated solely to food odors are currently lacking. Therefore, within this study, an innovative food-associated olfactory test (FAOT) system was developed. The FAOT comprises 16 odorant pens that contain representative food odors relating to different macronutrient classes. The test underwent a sensory validation based on identification rate, intensity, hedonic value, and food association scores...
January 2017: Chemical Senses
https://www.readbyqxmd.com/read/27659093/smelling-sulfur-copper-and-silver-regulate-the-response-of-human-odorant-receptor-or2t11-to-low-molecular-weight-thiols
#12
Shengju Li, Lucky Ahmed, Ruina Zhang, Yi Pan, Hiroaki Matsunami, Jessica L Burger, Eric Block, Victor S Batista, Hanyi Zhuang
Mammalian survival depends on ultrasensitive olfactory detection of volatile sulfur compounds, since these compounds can signal the presence of rancid food, O2 depleted atmospheres, and predators (through carnivore excretions). Skunks exploit this sensitivity with their noxious spray. In commerce, natural and liquefied gases are odorized with t-BuSH and EtSH, respectively, as warnings. The 100-million-fold difference in olfactory perception between structurally similar EtSH and EtOH has long puzzled those studying olfaction...
October 3, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27658749/are-people-who-have-a-better-smell-sense-more-affected-from-satiation
#13
Seckin Ulusoy, Mehmet Emre Dinc, Abdullah Dalgic, Murat Topak, Denizhan Dizdar, Abdulhalim İs
INTRODUCTION: The olfactory system is affected by the nutritional balance and chemical state of the body, serving as an internal sensor. All bodily functions are affected by energy loss, including olfaction; hunger can alter odour perception. OBJECTIVE: In this study, we investigated the effect of fasting on olfactory perception in humans, and also assessed perceptual changes during satiation. METHODS: The "Sniffin' Sticks" olfactory test was applied after 16h of fasting, and again at least 1h after Ramadan supper during periods of satiation...
September 12, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27594700/smelling-time-a-neural-basis-for-olfactory-scene-analysis
#14
REVIEW
Barry W Ache, Andrew M Hein, Yuriy V Bobkov, Jose C Principe
Behavioral evidence from phylogenetically diverse animals and from humans suggests that, by extracting temporal information inherent in the olfactory signal, olfaction is more involved in interpreting space and time than heretofore imagined. If this is the case, the olfactory system must have neural mechanisms capable of encoding time at intervals relevant to the turbulent odor world in which many animals live. Here, we review evidence that animals can use populations of rhythmically active or 'bursting' olfactory receptor neurons (bORNs) to extract and encode temporal information inherent in natural olfactory signals...
October 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27576679/olfactory-outcomes-after-endoscopic-sinus-surgery-for-chronic-rhinosinusitis-a-meta-analysis
#15
REVIEW
Preeti Kohli, Akash N Naik, Zachary Farhood, Adrian A Ong, Shaun A Nguyen, Zachary M Soler, Rodney J Schlosser
OBJECTIVE: To use combined pre- and postsurgical olfactory outcomes to assess the impact of endoscopic sinus surgery on chronic rhinosinusitis-related olfactory impairment. DATA SOURCES: CINAHL, Cochrane, OVID, EMBASE, PubMed, and SCOPUS. Each database was searched from inception up to October 2015. REVIEW METHODS: Studies were included that reported subjective or objective olfactory data in chronic rhinosinusitis patients before and after endoscopic sinus surgery...
December 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27552523/association-of-olfactory-dysfunction-in-chronic-rhinosinusitis-with-economic-productivity-and-medication-usage
#16
Rodney J Schlosser, Kristina A Storck, Luke Rudmik, Timothy L Smith, Jess C Mace, Jose Mattos, Zachary M Soler
BACKGROUND: Chronic rhinosinusitis (CRS) has significant impacts upon productivity, economic metrics, and medication usage; however, factors that are associated with these economic outcomes are unknown. METHODS: We evaluated olfactory dysfunction in 221 patients with CRS using the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS) and the 40-item Smell Identification Test (SIT) and assessed whether an association existed between these olfactory metrics and healthcare utilization, productivity, and medication usage over the preceding 90 days...
January 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27552396/smell-no-evil-copper-disrupts-the-alarm-chemical-response-in-a-diadromous-fish-galaxias-maculatus
#17
Oliver R B Thomas, Nicole C Barbee, Kathryn L Hassell, Stephen E Swearer
Fish, at all life stages, utilize olfactory information in the decision-making processes essential to survival. Olfaction is a sensitive sensory process, and toxicants within urban aquatic environments can have destructive or depreciating effects. In the present study, the authors exposed Galaxias maculatus, a native fish commonly found in urban waterways throughout southeastern Australia, to 1 of 5 ecologically relevant copper (II) chloride concentrations (<1 μg/L, 1 μg/L, 6 μg/L, 8 μg/L, 18 μg/L) for 16 h...
September 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27538667/the-combined-effect-of-rem-sleep-behavior-disorder-and-hyposmia-on-cognition-and-motor-phenotype-in-parkinson-s-disease
#18
Sung Hoon Kang, Hye Mi Lee, Woo-Keun Seo, Ji Hyun Kim, Seong-Beom Koh
BACKGROUND: Olfactory dysfunction and REM sleep behavior disorder (RBD) are recognized as pre-motor symptoms of Parkinson's disease (PD). Cognitive dysfunction is observed at a high rate even in the early stages of PD as an important non-motor symptom. PD has been classified in different subtypes and it is unknown if olfactory dysfunction and RBD occur more often in one particular subtype. We investigated the relationship between olfactory impairment, RBD, initial cognitive performance and motor phenotype in PD...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27527385/penguins-reduced-olfactory-receptor-genes-common-to-other-waterbirds
#19
Qin Lu, Kai Wang, Fumin Lei, Dan Yu, Huabin Zhao
The sense of smell, or olfaction, is fundamental in the life of animals. However, penguins (Aves: Sphenisciformes) possess relatively small olfactory bulbs compared with most other waterbirds such as Procellariiformes and Gaviiformes. To test whether penguins have a reduced reliance on olfaction, we analyzed the draft genome sequences of the two penguins, which diverged at the origin of the order Sphenisciformes; we also examined six closely related species with available genomes, and identified 29 one-to-one orthologous olfactory receptor genes (i...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27511295/odor-induced-recall-of-emotional-memories-in-ptsd-review-and-new-paradigm-for-research
#20
Judith K Daniels, Eric Vermetten
It is clinically well known that olfactory intrusions in PTSD can be a disabling phenomena due to the involuntary recall of odor memories. Odorants can trigger involuntary recall of emotional memories as well have the potential to help diminishing emotional arousal as grounding stimuli. Despite major advances in our understanding of the function of olfactory system, the study of the relation of olfaction and emotional memory is still relatively scarce. Odor memory is long thought to be different than other types of memories such as verbal or visual memories, being more strongly engraved and more closely related to strong emotions...
October 2016: Experimental Neurology
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