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https://www.readbyqxmd.com/read/28088055/marijuana-use-disorder-symptoms-among-recent-onset-marijuana-users
#1
Lisa Dierker, William Mendoza, Renee Goodwin, Arielle Selya, Jennifer Rose
BACKGROUND: With recreational marijuana having recently been legalized in a growing number of U.S. states, as well as the increasing support for its legalization among substantial segments of the American public, an understanding of the development of symptoms associated with marijuana use disorders will assist in guiding both education and policy. METHODS: This study examined the prevalence of marijuana use disorder symptoms among a nationally representative sample of recent onset marijuana users ages 12-21 drawn from the National Survey of Drug Use and Health (N=9697)...
January 6, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28087895/crohn-disease-risk-prediction-best-practices-and-pitfalls-with-exome-data
#2
Manuel Giollo, David T Jones, Marco Carraro, Emanuela Leonardi, Carlo Ferrari, Silvio C E Tosatto
The Critical Assessment of Genome Interpretation (CAGI) experiment is the first attempt to evaluate the state-of-the-art in genetic data interpretation. Among the proposed challenges, Crohn disease (CD) risk prediction has become the most classic problem spanning three editions. The scientific question is very hard: can anybody assess the risk to develop CD given the exome data alone? This is one of the ultimate goals of genetic analysis, which motivated most CAGI participants to look for powerful new methods...
January 13, 2017: Human Mutation
https://www.readbyqxmd.com/read/28087779/genomics-of-parallel-experimental-evolution-in-drosophila
#3
J L Graves, K L Hertweck, M A Phillips, M V Han, L G Cabral, T T Barter, L F Greer, M K Burke, L D Mueller, M R Rose
What are the genomic foundations of adaptation in sexual populations? We address this question using fitness-character and whole-genome sequence data from 30 Drosophila laboratory populations. These 30 populations are part of a nearly forty-year laboratory radiation featuring three selection regimes, each shared by ten populations for up to 837 generations, with moderately large effective population sizes. Each of three sets of ten populations that shared a selection regime consist of five populations that have long been maintained under that selection regime, paired with five populations that had only recently been subjected to that selection regime...
January 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28087770/article-discoveries
#4
Anke Konrad, Owen Thompson, Robert H Waterston, Donald G Moerman, Peter D Keightley, Ulfar Bergthorsson, Vaishali Katju
Mitochondrial genomes of metazoans, given their elevated rates of evolution, have served as pivotal markers for phylogeographic studies and recent phylogenetic events. In order to determine the dynamics of spontaneous mitochondrial mutations in small populations in the absence and presence of selection, we evolved mutation accumulation (MA) lines of Caenorhabditis elegans in parallel over 409 consecutive generations at three varying population sizes of N = 1, 10 and 100 hermaphrodites. The N =1 populations should have a minimal influence of natural selection to provide the spontaneous mutation rate and the expected rate of neutral evolution, whereas larger population sizes should experience increasing intensity of selection...
January 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28087661/disturbance-by-an-endemic-rodent-in-an-arid-shrubland-is-a-habitat-filter-effects-on-plant-invasion-and-taxonomical-functional-and-phylogenetic-community-structure
#5
Víctor M Escobedo, Rodrigo S Rios, Cristian Salgado-Luarte, Gisela C Stotz, Ernesto Gianoli
BACKGROUND AND AIMS: Disturbance often drives plant invasion and may modify community assembly. However, little is known about how these modifications of community patterns occur in terms of taxonomic, functional and phylogenetic structure. This study evaluated in an arid shrubland the influence of disturbance by an endemic rodent on community functional divergence and phylogenetic structure as well as on plant invasion. It was expected that disturbance would operate as a habitat filter favouring exotic species with short life cycles...
January 12, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28087658/are-winter-and-summer-dormancy-symmetrical-seasonal-adaptive-strategies-the-case-of-temperate-herbaceous-perennials
#6
REVIEW
Lauren M Gillespie, Florence A Volaire
BACKGROUND: Dormancy in higher plants is an adaptive response enabling plant survival during the harshest seasons and has been more explored in woody species than in herbaceous species. Nevertheless, winter and summer shoot meristem dormancy are adaptive strategies that could play a major role in enhancing seasonal stress tolerance and resilience of widespread herbaceous plant communities. SCOPE: This review outlines the symmetrical aspects of winter and summer dormancy in order to better understand plant adaptation to severe stress, and highlight research priorities in a changing climate...
January 13, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28087455/correlation-between-antigenicity-and-variability-in-the-vls-antigenic-variation-system-of-borrelia-burgdorferi
#7
Wei Zhou, Dustin Brisson
Many parasites have evolved antigenic variation systems that alter surface proteins in order to evade recognition by presently expressed antibodies and subsequent death. Although the amino acid positions in antigens to which antibodies most commonly target are expected to be the most variable, this assumption has not been investigated. Using the vls antigenic variation system of Borrelia burgdorferi as a model, we first investigated this assumption computationally and then developed a sensitive immunoassay to experimentally validate the computational results...
January 10, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28087255/unknown-face-of-known-drugs-what-else-can-we-expect-from-angiotensin-converting-enzyme-inhibitors
#8
REVIEW
Anna Wzgarda, Robert Kleszcz, Monika Prokop, Katarzyna Regulska, Milosz Regulski, Jaroslaw Paluszczak, Beata J Stanisz
The renin-angiotensin system (RAS) is one of important systems among homeostatic mechanisms that controls the function of cardiovascular, renal and adrenal systems. As RAS has a very complex nature, it has been also found as related to the control of cell migration and apoptosis. Angiotensin-converting enzyme inhibitors (ACEI) are drugs most commonly used in the modulation of RAS activity. ACEI have been extensively described as effective in the treatment of hypertension among adults, but also as drugs delaying progression in diabetic nephropathy and reducing mortality in left ventricular dysfunction and congestive heart failure...
January 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28087147/immune-responses-to-in-ovo-vaccine-formulations-containing-inactivated-fowl-adenovirus-8b-with-poly-di-sodium-carboxylatoethylphenoxy-phosphazene-pcep-and-avian-beta-defensin-as-adjuvants-in-chickens
#9
Mishal Sarfraz, Muhammed Suleman, Suresh K Tikoo, Colette Wheler, Andrew A Potter, Volker Gerdts, Arshud Dar
Inclusion body hepatitis (IBH) is one of the major viral infections causing substantial economic loss to the global poultry industry. The disease is characterized by a sudden onset of mortality (2-30%) and high morbidity (60-70%). IBH is caused by a number of serotypes of fowl adenovirus with substantially low levels of serotype cross protection. Thus far, there is no effective and safe vaccine commercially available in the North America for the control of IBH in chickens. Poly[di(sodium carboxylatoethylphenoxy)]phosphazene (PCEP) is a high molecular weight, biodegradable water soluble polymer that has been well characterized as a safe and effective adjuvant for a number of experimental veterinary vaccines...
January 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28086967/translation-cross-cultural-adaption-and-measurement-properties-of-the-evidence-based-practice-profile
#10
Kristine Berg Titlestad, Anne Kristin Snibsoer, Hilde Stromme, Monica Wammen Nortvedt, Birgitte Graverholt, Birgitte Espehaug
BACKGROUND: The evidence-based practice profile (EBP(2)) questionnaire assesses students' self-reported knowledge, behaviour and attitudes related to evidence-based practice. The aim of this study was to translate and cross-culturally adapt EBP(2) into Norwegian and to evaluate the reliability, validity and responsiveness of the Norwegian version. METHODS: EBP(2) was translated and cross-culturally adapted using recommended methodology. Face validity and feasibility were evaluated in a pilot on bachelor students and health and social workers (n = 18)...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28086898/the-intergenerational-production-of-depression-in-south-korea-results-from-a-cross-sectional-study
#11
B G Jeong, G Veenstra
BACKGROUND: Although a number of studies have uncovered relationships between parental capital and the manifestation of depression in their children, little is known about the mechanisms that undergird the relationships. This study investigates the intergenerational effects of the cultural and economic capitals of South Korean parents on depressive symptoms in their adult children and the degree to which the capitals of the adult children explain them. METHODS: We employed nationally representative cross-sectional survey data from the 2006 Korea Welfare Panel Study...
January 13, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28086895/design-optimization-of-stent-and-its-dilatation-balloon-using-kriging-surrogate-model
#12
Hongxia Li, Tao Liu, Minjie Wang, Danyang Zhao, Aike Qiao, Xue Wang, Junfeng Gu, Zheng Li, Bao Zhu
BACKGROUND: Although stents have great success of treating cardiovascular disease, it actually undermined by the in-stent restenosis and their long-term fatigue failure. The geometry of stent affects its service performance and ultimately affects its fatigue life. Besides, improper length of balloon leads to transient mechanical injury to the vessel wall and in-stent restenosis. Conventional optimization method of stent and its dilatation balloon by comparing several designs and choosing the best one as the optimal design cannot find the global optimal design in the design space...
January 11, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28086817/cost-of-shingles-population-based-burden-of-disease-analysis-of-herpes-zoster-and-postherpetic-neuralgia
#13
Kevin J Friesen, Dan Chateau, Jamie Falk, Silvia Alessi-Severini, Shawn Bugden
BACKGROUND: Around 30% of the population will experience herpes zoster (HZ), 10% of whom develop postherpetic neuralgia (PHN). Together, these illnesses produce a significant economic burden to the healthcare system. METHODS: Administrative healthcare data collected over the period of April 1(st) 1997 to March 31(st) 2014 were analyzed to determine the healthcare system burden of HZ using direct medical costs. Episodes of HZ were identified using international classification of disease (ICD) codes...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28086803/compendium-of-tcdd-mediated-transcriptomic-response-datasets-in-mammalian-model-systems
#14
Stephenie D Prokopec, Kathleen E Houlahan, Ren X Sun, John D Watson, Cindy Q Yao, Jamie Lee, Christine P'ng, Renee Pang, Alexander H Wu, Lauren C Chong, Ashley B Smith, Nicholas J Harding, Ivy D Moffat, Jere Lindén, Sanna Lensu, Allan B Okey, Raimo Pohjanvirta, Paul C Boutros
BACKGROUND: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of toxic outcomes, ranging from chloracne to acute lethality. The severity of toxicity is highly dependent on the aryl hydrocarbon receptor (AHR). Binding of TCDD to the AHR leads to changes in transcription of numerous genes. Studies evaluating the transcriptional changes brought on by TCDD may provide valuable insight into the role of the AHR in human health and disease...
January 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28086800/relevance-of-fxr-p62-sqstm1-pathway-for-survival-and-protection-of-mouse-hepatocytes-and-liver-especially-with-steatosis
#15
Sanae Haga, Yimin, Michitaka Ozaki
BACKGROUND: Liver injury and regeneration involve complicated processes and are affected by various physio-pathological conditions. Surgically, severe liver injury after surgical resection often leads to fatal liver failure, especially with some underlying pathological conditions such as steatosis. Therefore, protection from the injury of hepatocytes and liver is a serious concern in various clinical settings. METHODS: We studied the effects of the farnesoid X receptor (FXR) on cell survival and steatosis in mouse hepatocytes (AML12 mouse liver cells) and investigated their molecular mechanisms...
January 13, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28086766/psychoeducational-preventive-treatment-for-women-at-risk-of-postpartum-depression-study-protocol-for-a-randomized-controlled-trial-progea
#16
Amaia Ugarte Ugarte, Purificación López-Peña, Carmen Serrulla Vangeneberg, Julia Gemma Torregaray Royo, Maria Asunción Arrieta Ugarte, Maria Teresa Zabalza Compains, Maria Pilar Riaño Medrano, Nerea Muñoz Toyos, Edurne Arenaza Lamo, Maria Begoña Beneitez Dueñas, Ana González-Pinto
BACKGROUND: Postpartum depression is a disease with a prevalence of 20% that has deleterious consequences not only for the mother but also for the baby and can cause delays in physical, social and cognitive development. In this context, the European Union Committee on Public Health has declared it essential that preventative measures are taken by centres providing care for women with a multidisciplinary approach. PROGEA is a multicentre, single-blind randomized, 3-year, longitudinal clinical trial aiming to evaluate the efficacy of a psychoeducational programme in preventing postpartum depression in at-risk women, based on a range of clinical variables, and explore prognostic factors...
January 13, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28081566/a-novel-phytophthora-sojae-resistance-rps12-gene-mapped-to-a-genomic-region-that-contains-several-rps-genes
#17
Dipak K Sahoo, Nilwala S Abeysekara, Silvia R Cianzio, Alison E Robertson, Madan K Bhattacharyya
Phytophthora sojae Kaufmann and Gerdemann, which causes Phytophthora root rot, is a widespread pathogen that limits soybean production worldwide. Development of Phytophthora resistant cultivars carrying Phytophthora resistance Rps genes is a cost-effective approach in controlling this disease. For this mapping study of a novel Rps gene, 290 recombinant inbred lines (RILs) (F7 families) were developed by crossing the P. sojae resistant cultivar PI399036 with the P. sojae susceptible AR2 line, and were phenotyped for responses to a mixture of three P...
2017: PloS One
https://www.readbyqxmd.com/read/28081550/ninth-grade-school-performance-in-danish-childhood-cancer-survivors
#18
Klaus Kaae Andersen, Anne Katrine Duun-Henriksen, Marie Hoffmann Frederiksen, Jeanette Falck Winther
BACKGROUND: Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. METHODS: We analysed nationwide Danish registries on school grades for Danish children during 2001-2014. Applying a matched design we compared grades of childhood cancer survivors to children without cancer at ninth grade. We estimated grade differences by subject and its correlation to cancer site and age at diagnosis...
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28081187/perceptual-space-of-superimposed-dual-frequency-vibrations-in-the-hands
#19
Inwook Hwang, Jeongil Seo, Seungmoon Choi
The use of distinguishable complex vibrations that have multiple spectral components can improve the transfer of information by vibrotactile interfaces. We investigated the qualitative characteristics of dual-frequency vibrations as the simplest complex vibrations compared to single-frequency vibrations. Two psychophysical experiments were conducted to elucidate the perceptual characteristics of these vibrations by measuring the perceptual distances among single-frequency and dual-frequency vibrations. The perceptual distances of dual-frequency vibrations between their two frequency components along their relative intensity ratio were measured in Experiment I...
2017: PloS One
https://www.readbyqxmd.com/read/28081011/spectrum-reconstruction-method-based-on-the-detector-response-model-calibrated-by-x-ray-fluorescence
#20
Ruizhe Li, Liang Li, Zhiqiang Chen
Accurate estimation of distortion-free spectra is important but difficult in various applications, especially for spectral computed tomography. Two key problems must be solved to reconstruct the incident spectrum. One is the acquisition of the detector energy response. It can be calculated by Monte Carlo simulation, which requires detailed modeling of the detector system and a high computational power. It can also be acquired by establishing a parametric response model and be calibrated using monochromatic x-ray sources, such as synchrotron sources or radioactive isotopes...
January 12, 2017: Physics in Medicine and Biology
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