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https://www.readbyqxmd.com/read/29778677/growth-impacts-of-saharan-dust-mineral-nutrients-and-co-2-on-a-planktonic-herbivore-in-southern-mediterranean-lakes
#1
Manuel Villar-Argaiz, Marco J Cabrerizo, Juan Manuel González-Olalla, Macarena S Valiñas, Sanja Rajic, Presentación Carrillo
Rising levels of CO2 can boost plant biomass but reduce its quality as a food source for herbivores. However, significant uncertainties remain as to the degree to which the effect is modulated by other environmental factors and the underlying processes causing these responses in nature. To address these questions, we carried out CO2 -manipulation experiments using natural seston from three lakes under nutrient-enriched conditions (mimicking eutrophication and atmospheric dust-input processes) as a food source for the planktonic Daphnia pulicaria...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29778506/quality-of-life-symptoms-and-care-needs-in-patients-with-persistent-or-recurrent-platinum-resistant-ovarian-cancer-an-nrg-oncology-gynecologic-oncology-group-study
#2
Vivian E von Gruenigen, Helen Q Huang, David Cella, MichaelA Zevon, Jason A LaChance, Joan L Walker, Ritu Salani, Susan C Modesitt, Robert T Morris, William H Bradley, Matthew P Boente, Lari Wenzel
OBJECTIVES: The goals of treating recurrent platinum-resistant ovarian cancer are palliative, aimed at reducing symptoms and improving progression free survival. A prospective trial was conducted to determine the prevalence and severity of symptoms, and associated care needs. METHODS: Eligible women included those with persistent or recurrent platinum-resistant ovarian cancer with an estimated life expectancy of at least 6 months. The Needs at the End-of-Life Screening Tool (NEST), FACIT-Fatigue (FACIT-F), NCCN-FACT Ovarian Symptom Index [NFOSI-18]; Disease Related Symptoms (DRS), Treatment Side Effects (TSE), and Function/Well Being (F/WB) were collected at study entry, 3 and 6 months...
May 17, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29778461/average-ovarian-hormone-levels-rather-than-daily-values-and-their-fluctuations-are-related-to-facial-preferences-among-women
#3
Urszula M Marcinkowska, Gwenael Kaminski, Anthony C Little, Grazyna Jasienska
Hormones are of crucial importance for human behavior. Cyclical changes of ovarian hormones throughout women's menstrual cycle are suggested to underlie fluctuation in masculinity preference for both faces and bodies. In this study we tested this hypothesis based on daily measurements of estradiol and progesterone throughout menstrual cycle, and multiple measurements of women's preference towards masculinity of faces and bodies of men. We expected that due to a large variation among daily hormonal levels we would not observe a direct effect of daily hormone levels, but rather that average levels of ovarian hormones throughout the cycle (a reliable marker of a probability of conception) would better predict women's preferences...
May 17, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29778042/reliability-and-validity-of-the-dymus-questionnaire-for-the-assessment-of-dysphagia-in-multiple-sclerosis-greek-version-and-proposed-modification
#4
Athanasia Printza, Maria Kalaitzi, Christos Bakirtzis, Ioannis Nikolaidis, Hariklia Proios, Nikolaos Grigoriadis
BACKGROUND: Recent research confirmed that at least a third of people with multiple sclerosis (MS) are suffering from swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, and has profound impact on physical ability and quality of life. Dysphagia related complications can be prevented through an effective screening protocol. The Dysphagia in Multiple Sclerosis (DYMUS) questionnaire is the first dysphagia questionnaire developed specifically for patients with MS...
May 10, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29777864/effectiveness-on-maternal-and-offspring-metabolic-control-of-a-home-based-dietary-counseling-intervention-and-dha-supplementation-in-obese-overweight-pregnant-women-might-study-a-randomized-controlled-trial-study-protocol
#5
María Luisa Garmendia, Camila Corvalán, Paola Casanello, B Marcela Araya, Marcela Flores, Alfredo Bravo, Juan Pedro Kusanovic, Pablo Olmos, Ricardo Uauy
BACKGROUND: Lifestyle interventions are the primary prevention strategy for gestational diabetes (GDM) in obese/overweight women; however, these interventions have shown limited effectiveness. Omega-3 polyunsaturated fatty acids (PUFAs) intake has shown beneficial effects on glucose metabolism, lipid fractions and inflammatory factors in women who already have GDM. Combining PUFAs supplementation with a lifestyle intervention could achieve lower increase of glucose levels by improving insulin sensitivity...
May 16, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29777843/underexpansion-of-wallstents%C3%A2-in-the-treatment-of-nonthrombotic-iliac-vein-lesions
#6
Jacob E Mandel, Yuriy Ostrozhynskyy, Anil Hingorani, Natalie Marks, Enrico Ascher
OBJECTIVE: Iliac vein stenting is increasingly being used in the treatment of venous insufficiency for patients with nonthrombotic iliac vein lesions (NIVL). We have noticed that many stents do not deploy to the expected stent area as designated by the manufactured diameter. The purpose of this study was to evaluate the dynamics of Wallstent® expansion in the iliocaval system. METHODS: Retrospective analysis of all patients with NIVL who were treated with iliac vein stenting using Wallstents®...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777741/effect-of-exposure-to-similar-flavours-in-sensory-specific-satiety-implications-for-eating-behaviour
#7
Ana González, Sergio Andrés Recio, Jesús Sánchez, Marta Gil, Isabel de Brugada
Sensory-specific satiety (SSS) refers to a decline in pleasantness of eaten foods in comparison to other non-ingested meals. Although SSS is specific to the eaten food, it can also generalize to other meals that share similar properties to the satiated food. It is possible that this phenomenon could become more specific after extensive experience, as repeated exposure to an assortment of similar food could cause perceptual learning (i.e. an increase in the distinctiveness of each specific item). This in turn would reduce generalization from the consumed food to other similar products, so they will be more readily consumed...
May 16, 2018: Appetite
https://www.readbyqxmd.com/read/29777740/rapid-response-systems
#8
REVIEW
Patrick G Lyons, Dana P Edelson, Matthew M Churpek
INTRODUCTION: Rapid response systems are commonly employed by hospitals to identify and respond to deteriorating patients outside of the intensive care unit. Controversy exists about the benefits of rapid response systems. AIMS: We aimed to review the current state of the rapid response literature, including evolving aspects of afferent (risk detection) and efferent (intervention) arms, outcome measurement, process improvement, and implementation. DATA SOURCES: Articles written in English and published in PubMed...
May 16, 2018: Resuscitation
https://www.readbyqxmd.com/read/29777620/vegetation-growth-enhancement-in-urban-environments-of-the-conterminous-united-states
#9
Wenxiao Jia, Shuqing Zhao, Shuguang Liu
Cities are natural laboratories for studying vegetation responses to global environmental changes because of their climate, atmospheric, and biogeochemical conditions. However, few holistic studies have been conducted on the impact of urbanization on vegetation growth. We decomposed the overall impacts of urbanization on vegetation growth into direct (replacement of original land surfaces by impervious built-up) and indirect (urban environments) components, using a conceptual framework and remotely-sensed data for 377 metropolitan statistical areas (MSAs) in the conterminous United States (CONUS) in 2001, 2006, and 2011...
May 19, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29777614/enhancing-the-detection-of-injuries-and-near-misses-among-patient-care-staff-in-a-large-pediatric-hospital
#10
Maurizio Macaluso, Lauren A Summerville, Meredith E Tabangin, Nancy M Daraiseh
Objectives Compared to other industries, healthcare has one of the highest rates of non-fatal occupational injury/illness. Evidence indicates these rates are underestimated, highlighting the need for improved injury surveillance. This study aims to demonstrate the feasibility of integrating active data collection in a passive injury surveillance system to improve detection of injuries in a healthcare establishment. Methods Using digital voice recorders (DVR), pediatric healthcare providers prospectively recorded events throughout their shift for two weeks...
May 7, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29777569/improving-metabolic-stability-with-deuterium-the-discovery-of-hwl-066-a-potent-and-long-acting-free-fatty-acid-receptor-1-agonists
#11
Chunxia Liu, Zheng Li, Wei Shi, Huilan Li, Nasi Wang, Yuxuan Dai, Chen Liao, Wenlong Huang, Hai Qian
The free fatty acid receptor 1 (FFA1) is a potential target due to its function in enhancing of glucose-stimulated insulin secretion. The FFA1 agonist GW9508 has great potential for the treatment of type 2 diabetes mellitus, but it has been suffering from high plasma clearance probably because the phenylpropanoic acid is vulnerable to β-oxidation. To identify orally available analog without influence on the unique pharmacological mechanism of GW9508, we tried to interdict the metabolically labile group by incorporating two deuterium atoms at the α-position of phenylpropionic acid affording compound 4 (HWL-066)...
May 18, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29777501/expression-of-endogenous-proteins-in-maize-hybrids-in-a-multi-location-field-trial-in-india
#12
Linga R Gutha, Divakar Purushottam, Aruna Veeramachaneni, Sarita Tigulla, Vikas Kodappully, Chandana Enjala, Hitendrasinh Rajput, Jennifer Anderson, Bonnie Hong, Jean Schmidt, Shveta Bagga
Genetically modified (GM) crops undergo large scale multi-location field trials to characterize agronomics, composition, and the concentration of newly expressed protein(s) [herein referred to as transgenic protein(s)]. The concentration of transgenic proteins in different plant tissues and across the developmental stages of the plant is considered in the safety assessment of GM crops. Reference or housekeeping proteins are expected to maintain a relatively stable expression pattern in healthy plants given their role in cellular functions...
May 17, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29777437/the-impact-of-anatomical-and-spatial-distance-between-responses-on-response-conflict
#13
Peter Wühr, Herbert Heuer
Different features of objects can be associated with different responses, so that their concurrent presence results in conflict. The Simon effect is a prominent example of this type of response conflict. In two experiments, we ask whether it is modulated by the anatomical or spatial relation between responses. Predictions were derived from an extended variant of the leaky, competing accumulator (LCA) model proposed by Usher and McClelland (Psychological Review, 108, 550-592, 2001). The relation between responses was represented by the lateral-inhibition parameter of the model...
May 17, 2018: Memory & Cognition
https://www.readbyqxmd.com/read/29777372/cardiac-surgery-2017-reviewed
#14
REVIEW
Torsten Doenst, Hristo Kirov, Alexandros Moschovas, David Gonzalez-Lopez, Rauf Safarov, Mahmoud Diab, Steffen Bargenda, Gloria Faerber
For the year 2017, more than 21,000 published references can be found in PubMed when entering the search term "cardiac surgery". This review focusses on conventional cardiac surgery, considering the new interventional techniques only if they were directly compared to classic techniques but also entails aspects of perioperative intensive care management. The publications last year provided a plethora of new and interesting information that helped to quantify classic surgical treatment effects and provided new guidelines for the management of structural heart disease, which made comparisons to interventional techniques easier...
May 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29777174/how-does-blood-regulate-cerebral-temperatures-during-hypothermia
#15
Stephen Blowers, Ian Marshall, Michael Thrippleton, Peter Andrews, Bridget Harris, Iain Bethune, Prashant Valluri
Macro-modeling of cerebral blood flow can help determine the impact of thermal intervention during instances of head trauma to mitigate tissue damage. This work presents a bioheat model using a 3D fluid-porous domain coupled with intersecting 1D arterial and venous vessel trees. This combined vascular porous (VaPor) model resolves both cerebral blood flow and energy equations, including heat generated by metabolism, using vasculature extracted from MRI data and is extended using a tree generation algorithm...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29777005/predictors-of-survival-in-211-patients-with-stage-iv-pulmonary-and-gastroenteropancreatic-mibg-positive-neuroendocrine-tumors-treated-with-i-131-mibg
#16
Ari Kane, Matthew P Thorpe, Jorge D Oldan, Brandon A Howard, Jason Zhu, Michael A Morse, Terence Wong, Neil A Petry, Robert Reiman, Salvador Borges-Neto
Purpose: This retrospective analysis identifies predictors of survival in a cohort of patients with mIBG positive stage IV pulmonary and gastroenteropancreatic neuroendocrine tumor (P/GEP-NET) treated with I-131 mIBG therapy, in order to inform treatment selection and post-treatment monitoring. Methods: Survival, symptoms, imaging, and biochemical response were extracted via chart review from n = 211 P/GEP-NET patients treated with mIBG between 1991-2014. For patients with computed tomography (CT) follow up ( n = 125), imaging response was assessed by Response Evaluation Criteria on Solid Tumors (RECIST) 1...
May 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29776953/the-landscape-of-actionable-genomic-alterations-in-cell-free-circulating-tumor-dna-from-21-807-advanced-cancer-patients
#17
Oliver A Zill, Kimberly C Banks, Stephen R Fairclough, Stefanie Mortimer, James V Vowles, Reza Mokhtari, David R Gandara, Philip C Mack, Justin I Odegaard, Rebecca J Nagy, Arthur M Baca, Helmy Eltoukhy, Darya I Chudova, Richard B Lanman, AmirAli Talasaz
PURPOSE: Cell-free DNA (cfDNA) sequencing provides a non-invasive method for obtaining actionable genomic information to guide personalized cancer treatment, but the presence of multiple alterations in circulation related to treatment and tumor heterogeneity complicate the interpretation of the observed variants. Experimental Design: We describe the somatic mutation landscape of 70 cancer genes from cfDNA deep-sequencing analysis of 21,807 patients with treated, late-stage cancers across >50 cancer types...
May 18, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29776887/satisfaction-fulfillment-of-expectations-and-adherence-to-subcutaneous-biological-drugs-in-patients-with-rheumatoid-arthritis-arco-study
#18
Jaime Calvo-Alén, Paloma Vela, Sagrario Bustabad, Francisco Maceiras, Loreto Carmona, Luis Cea-Calvo
OBJECTIVES: In the ARCO study, adherence to subcutaneous biological agents by patients with rheumatoid arthritis improved with monthly administration. We assess whether adherence can be related to fulfillment of expectations and satisfaction with treatment. PATIENTS AND METHODS: Adherence was assessed by calculating the Medication Possession Ratio, and satisfaction and fulfillment of expectations using the «EXPRESAR» group questionnaire. RESULTS: In 346 patients, those who were satisfied/very satisfied with efficacy and tolerability were ≥80% and 64...
May 15, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29776689/on-the-nexus-of-air-pollution-and-health-expenditures-new-empirical-evidence
#19
Carla Blázquez-Fernández, David Cantarero-Priento, Marta Pascual-Sáez
OBJECTIVE: To analyse the impact of per capita income and environmental air quality variables on health expenditure determinants. METHOD: In this study, we analyse the relationship between air pollution and health expenditure in 29 OECD countries over the period 1995-2014. In addition, we test whether our findings differ between countries with higher or lower incomes. RESULTS: The econometric results show that per capita income has a positive effect on health expenditure, but is not as statistically significant as expected when lag-time is incorporated...
May 15, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29776527/is-there-agreement-between-worker-self-and-supervisor-assessment-of-worker-safety-performance-an-examination-in-the-construction-industry
#20
Nini Xia, Mark A Griffin, Xueqing Wang, Xing Liu, Dan Wang
INTRODUCTION: Individual safety performance (behavior) critically influences safety outcomes in high-risk workplaces. Compared to the study of generic work performance on different measurements, few studies have investigated different measurements of safety performance, typically relying on employees' self-reflection of their safety behavior. This research aims to address this limitation by including worker self-reflection and other (i.e., supervisor) assessment of two worker safety performance dimensions, safety compliance and safety participation...
June 2018: Journal of Safety Research
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