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https://www.readbyqxmd.com/read/28719827/mixed-evidence-for-the-potential-of-non-invasive-transcutaneous-vagal-nerve-stimulation-to-improve-the-extinction-and-retention-of-fear
#1
A M Burger, B Verkuil, H Fenlon, L Thijs, L Cools, H C Miller, B Vervliet, I Van Diest
Extinction memories are fragile and their formation has been proposed to partially rely on vagus nerve activity. We tested whether stimulating the auricular branch of the vagus (transcutaneous VNS; tVNS) accelerates extinction and reduces spontaneous recovery of fear. Forty-two healthy students participated in a 3-day fear conditioning study, where we tested fear acquisition (day 1), fear extinction (day 2) and the retention of the extinction memory (day 3). During extinction, participants were randomly allocated to receive tVNS or sham stimulation concurrently with each CS presentation...
July 8, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28719745/highly-efficient-water-decontamination-by-using-sub-10-nm-feooh-confined-within-millimeter-sized-mesoporous-polystyrene-beads
#2
Xiaolin Zhang, Cheng Cheng, Jieshu Qian, Zhenda Lu, Siyuan Pan, Bing-Cai Pan
Millimeter-sized polymer-based FeOOH nanoparticles (NPs) provide a promising option to overcome the bottlenecks of direct use of NPs in scaled-up water purification, and decreasing the NP size below 10 nm is expected to improve the decontamination efficiency of the polymeric nanocomposites due to the size and surface effect. However, it is still challenging to control the dwelled FeOOH NP sizes to sub-10 nm, mainly due to the wide pore size distribution of the currently available polymeric hosts. Herein, we synthesized mesoporous polystyrene beads (MesoPS) via flash freezing to assemble FeOOH NPs...
July 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28719658/optisampletm-open-web-based-application-to-optimize-sampling-strategies-for-active-surveillance-activities-at-the-herd-level-illustrated-using-porcine-respiratory-reproductive-syndrome-prrs
#3
Anna Alba, Robert E Morrison, Ann Cheeran, Albert Rovira, Julio Alvarez, Andres M Perez
Porcine reproductive and respiratory syndrome virus (PRRSv) infection causes a devastating economic impact to the swine industry. Active surveillance is routinely conducted in many swine herds to demonstrate freedom from PRRSv infection. The design of efficient active surveillance sampling schemes is challenging because optimum surveillance strategies may differ depending on infection status, herd structure, management, or resources for conducting sampling. Here, we present an open web-based application, named 'OptisampleTM', designed to optimize herd sampling strategies to substantiate freedom of infection considering also costs of testing...
2017: PloS One
https://www.readbyqxmd.com/read/28719607/stress-induced-mutagenesis-stress-diversity-facilitates-the-persistence-of-mutator-genes
#4
Marta Lukačišinová, Sebastian Novak, Tiago Paixão
Mutator strains are expected to evolve when the availability and effect of beneficial mutations are high enough to counteract the disadvantage from deleterious mutations that will inevitably accumulate. As the population becomes more adapted to its environment, both availability and effect of beneficial mutations necessarily decrease and mutation rates are predicted to decrease. It has been shown that certain molecular mechanisms can lead to increased mutation rates when the organism finds itself in a stressful environment...
July 18, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28719223/from-bench-to-bedside-converting-placebo-research-into-belief-activation
#5
Jen Green, Heather Wright
Research on the placebo effect contains important elements that can be harnessed to improve clinical care. This paper proposes a new term, "Belief Activation," to describe the deliberate use of placebo effect tools by both patients and clinicians to catalyze healing. Belief Activation includes, but is not limited to, maximizing patient and practitioner expectations, classical and social conditioning, spirituality and prayer/intention, therapeutic relationship, healing environments, and minimizing the nocebo effect...
July 18, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28719081/drought-induced-mortality-patterns-and-rapid-biomass-recovery-in-a-terra-firme-forest-in-the-colombian-amazon
#6
Daniel Zuleta, Alvaro Duque, Dairon Cardenas, Helene C Muller-Landau, Stuart Davies
Extreme climatic events affecting the Amazon region are expected to become more frequent under ongoing climate change. In this study, we assessed the responses to the 2010 drought of over 14,000 trees ≥ 10 cm dbh in a 25 ha lowland forest plot in the Colombian Amazon and how these responses varied among topographically defined habitats, with tree size, and with species wood density. Tree mortality was significantly higher during the 2010-2013 period immediately after the drought than in 2007-2010. The post-drought increase in mortality was stronger for trees located in valleys (+243%) than for those located on slopes (+67%) and ridges (+57%)...
July 18, 2017: Ecology
https://www.readbyqxmd.com/read/28718816/complex-dna-damage-a-route-to-radiation-induced-genomic-instability-and-carcinogenesis
#7
REVIEW
Ifigeneia V Mavragani, Zacharenia Nikitaki, Maria P Souli, Asef Aziz, Somaira Nowsheen, Khaled Aziz, Emmy Rogakou, Alexandros G Georgakilas
Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly damaging since radiation can perturb all important components of the cell, from the membrane to the nucleus, due to alteration of different biological molecules ranging from lipids to proteins or DNA. Regarding DNA damage, which is the main focus of this review, as well as its repair, all current knowledge indicates that IR-induced DNA damage is always more complex than the corresponding endogenous damage resulting from endogenous oxidative stress...
July 18, 2017: Cancers
https://www.readbyqxmd.com/read/28718729/the-novel-autophagy-inhibitor-elaiophylin-exerts-antitumor-activity-against-multiple-myeloma-with-mutant-tp53-in-part-through-endoplasmic-reticulum-stress-induced-apoptosis
#8
Wang Gaoxiang, Zhou Pan, Chen Xing, Lei Zhao, Tan Jiaqi, Yang Yang, Yong Fang, Jianfeng Zhou
Elaiophylin is a natural compound and a novel and potent inhibitor of late stage autophagy with outstanding antitumor activity in human ovarian cancer cells. However, the possible biological effects and functional linkage between elaiophylin and multiple myeloma (MM) have not been explored. This study aimed to assess the effect of elaiophylin on MM cells with mutant TP53 and the possible molecular mechanism. The results suggested that elaiophylin exerted anti-myeloma activity by inducing apoptosis and proliferation arrest...
July 18, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28718649/ensemble-and-single-particle-fluorescence-characterization-of-dye-labeled-cellulose-nanocrystals
#9
Tianyang Leng, Zygmunt J Jakubek, Mahyar Mazloumi, Alfred C W Leung, Linda J Johnston
Cellulose nanocrystals (CNCs) have been covalently labeled with both fluorescein and rhodamine and studied by a combination of UV-Vis absorption spectroscopy and ensemble and single molecule fluorescence spectroscopy. For all samples the fluorescence anisotropy and lifetimes were consistent with effects expected for covalently bound dye molecules. Low dye loading levels (~ 0.1 dye/particle) were estimated for the fluorescein-labeled CNC which coupled with the strong pH dependence make this a less suitable fluorophore for most applications...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28718354/mercury-induced-motor-and-sensory-neurotoxicity-systematic-review-of-workers-currently-exposed-to-mercury-vapor
#10
Cheryl A Fields, Jonathan Borak, Elan D Louis
The neurotoxicity of elemental mercury (Hg(0)) is well-recognized, but it is uncertain whether and for how long neurotoxicity persists; among studies that evaluated previously exposed workers, only one examined workers during and also years after exposure ceased. The aim of this review is to document the type, frequency, and dose-relatedness of objective neurological effects in currently exposed mercury workers and thereby provide first approximations of the effects one would have expected in previously exposed workers evaluated during exposure...
July 18, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28718326/cns-anticancer-drug-discovery-and-development-2016-conference-insights
#11
Victor A Levin, Lauren E Abrey, Timothy P Heffron, Peter J Tonge, Arvin C Dar, William A Weiss, James M Gallo
CNS Anticancer Drug Discovery and Development November 2016, AZ, USA The 2016 second CNS Anticancer Drug Discovery and Development Conference addressed diverse viewpoints about why new drug discovery/development focused on CNS cancers has been sorely lacking. Despite more than 70,000 individuals in the USA being diagnosed with a primary brain malignancy and 151,669-286,486 suffering from metastatic CNS cancer, in 1999, temozolomide was the last drug approved by the US FDA as an anticancer agent for high-grade gliomas...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28718174/object-substitution-masking-weakens-but-does-not-eliminate-shape-interactions
#12
Timothy D Sweeny, Larissa C D'Abreu, Elric Elias, Lauren Padama
At any moment, some objects in the environment are seen clearly, whereas others go unnoticed. Whether or not these gaps in awareness are actually problematic may depend on the extent that information about unseen objects is lost. Determining when and how visual awareness and visual processing become linked is thus of great importance. Previous research using object-substitution masking (OSM) demonstrated that relatively simple visual features, such as size or orientation, are still processed even when they are not visible...
July 17, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28718058/cultural-biases-in-current-medical-practices-with-a-specific-attention-to-orthopedic-surgery-a-review
#13
Gracia Etienne, Todd P Pierce, Anton Khlopas, Morad Chughtai, Carlos J Lavernia, Teva Y Vogelstein, Craig M Thomas, Charles S Modlin, Michael A Mont
Due to the increasing diversity within the United States population, there is an ever-increasing need for increased education on cultural literacy and tolerance in medical schools and residency programs. The purpose of this article was to review how a person's culture can play a substantive role in effecting and influencing (1) medical diagnosis, (2) patient and health provider medical decision-making, (3) the patient's perception of disease, and (4) the doctor-patient relationships. Many of the decisions we make as orthopedic surgeons must account for the patient's cultural needs, as much of our work impacts patients' daily activities and function...
July 17, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28717880/environmental-exposure-does-not-explain-putative-maladaptation-in-road-adjacent-populations
#14
Steven P Brady
While the ecological consequences of roads are well described, little is known of their role as agents of natural selection, which can shape adaptive and maladaptive responses in populations influenced by roads. This knowledge gap persists despite a growing appreciation for the influence of evolution in human-altered environments. There, insights indicate that natural selection typically results in local adaptation. Thus, populations influenced by road-induced selection should evolve fitness advantages in their local environment...
July 17, 2017: Oecologia
https://www.readbyqxmd.com/read/28717871/sleeve-gastrectomy-telementoring-a-sages-multi-institutional-quality-improvement-initiative
#15
Ninh T Nguyen, Allan Okrainec, Mehran Anvari, Brian Smith, Oz Meireles, Denise Gee, Erin Moran-Atkin, Evelyn Baram-Clothier, Diego R Camacho
BACKGROUND: Sleeve gastrectomy is a relatively new procedure that developed as a result of rapid innovation in the field of bariatric surgery. As with any newly developed operation, there is a learning curve that potentially can be associated with higher morbidity. Real-time surgical mentoring reduces the learning curve effect but can be time intensive for the mentor. The aim of this initiative was to evaluate the feasibility, effectiveness, and satisfaction of surgical telementoring for laparoscopic sleeve gastrectomy...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28717860/performance-of-the-diarem-score-for-predicting-diabetes-remission-in-two-health-systems-following-bariatric-surgery-procedures-in-hispanic-and-non-hispanic-white-patients
#16
G Craig Wood, Daniel Horwitz, Christopher D Still, Tooraj Mirshahi, Peter Benotti, Manish Parikh, Annemarie G Hirsch
OBJECTIVE: The objective of this study was to determine whether the DiaRem, a score that predicts type 2 diabetes (T2D) remission following roux-en-y gastric bariatric surgery (RYGB), also predicts remission following laparoscopic adjustable gastric banding (LAGB) and laparoscopic sleeve gastrectomy (LSG) in white and Hispanic patients. BACKGROUND: While bariatric surgery is highly effective in reversing insulin resistance, there are patients for whom surgery will not lead to remission...
July 17, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28717514/gyrations-in-african-mortality-and-their-effect-on-economic-growth
#17
David N Weil
I examine recent changes in African mortality and discuss their potential economic and demographic effects. Growth in life expectancy sharply departed from its trend after 1990, and then experienced a sharp acceleration after 2005. This latter acceleration was due overwhelmingly to improvements in HIV and malaria. Economists differ in their estimates of how large the structural effect of health on income is, with many estimates being relatively small. Taking seriously the delays built into many plausible causal channels would lead one to expect that any economic effects of these mortality changes, if they are detectable at all, will not appear for several decades...
March 2017: Journal of Demographic Economics
https://www.readbyqxmd.com/read/28717111/usefulness-of-cardiotoxicity-assessment-using-calcium-transient-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#18
Hitoshi Watanabe, Yayoi Honda, Jiro Deguchi, Toru Yamada, Kiyoko Bando
Monitoring dramatic changes in intracellular calcium ion levels during cardiac contraction and relaxation, known as calcium transient, in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) would be an attractive strategy for assessing compounds on cardiac contractility. In addition, as arrhythmogenic compounds are known to induce characteristic waveform changes in hiPSC-CMs, it is expected that calcium transient would allow evaluation of not only compound-induced effects on cardiac contractility, but also compound arrhythmogenic potential...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28717108/isoflurane-is-a-suitable-alternative-to-ether-for-anesthetizing-rats-prior-to-euthanasia-for-gene-expression-analysis
#19
Noriyuki Nakatsu, Yoshinobu Igarashi, Taiki Aoshi, Isao Hamaguchi, Masumichi Saito, Takuo Mizukami, Haruka Momose, Ken J Ishii, Hiroshi Yamada
Diethyl ether (ether) had been widely used in Japan for anesthesia, despite its explosive properties and toxicity to both humans and animals. We also had used ether as an anesthetic for euthanizing rats for research in the Toxicogenomics Project (TGP). Because the use of ether for these purposes will likely cease, it is required to select an alternative anesthetic which is validated for consistency with existing TGP data acquired under ether anesthesia. We therefore compared two alternative anesthetic candidates, isoflurane and pentobarbital, with ether in terms of hematological findings, serum biochemical parameters, and gene expressions...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28716892/which-dengue-vaccine-approach-is-the-most-promising-and-should-we-be-concerned-about-enhanced-disease-after-vaccination-questions-raised-by-the-development-and-implementation-of-dengue-vaccines-example-of-the-sanofi-pasteur-tetravalent-dengue-vaccine
#20
Bruno Guy
Dengue is a still-growing public health concern in many tropical and subtropical regions of the world. The development and implementation of an effective dengue vaccine in these regions is a high priority. This insight focuses on the expected characteristics of a safe and efficacious vaccine, referring to the clinical experience obtained during the development of the first tetravalent dengue vaccine from Sanofi Pasteur, now licensed in several endemic countries. Safety and efficacy data from both short- and long-term follow-up of large-scale efficacy studies will be discussed, as well as the next steps following vaccine introduction...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
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