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https://www.readbyqxmd.com/read/29929212/pharmacological-therapies-for-management-of-opium-withdrawal
#1
REVIEW
Afarin Rahimi-Movaghar, Jaleh Gholami, Laura Amato, Leila Hoseinie, Reza Yousefi-Nooraie, Masoumeh Amin-Esmaeili
BACKGROUND: Pharmacologic therapies for management of heroin withdrawal have been studied and reviewed widely. Opium dependence is generally associated with less severe dependence and milder withdrawal symptoms than heroin. The evidence on withdrawal management of heroin might therefore not be exactly applicable for opium. OBJECTIVES: To assess the effectiveness and safety of various pharmacologic therapies for the management of the acute phase of opium withdrawal...
June 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29929186/increased-fatty-acid-oxidation-in-differentiated-proximal-tubular-cells-surviving-a-reversible-episode-of-acute-kidney-injury
#2
Aurélien Bataille, Pierre Galichon, Nadjim Chelghoum, Badreddine Mohand Oumoussa, Marie-Julia Ziliotis, Iman Sadia, Sophie Vandermeersch, Noémie Simon-Tillaux, David Legouis, Raphaël Cohen, Yi-Chun Xu-Dubois, Morgane Commereuc, Eric Rondeau, Stéphane Le Crom, Alexandre Hertig
BACKGROUND/AIMS: Fatty acid oxidation (FAO), the main source of energy produced by tubular epithelial cells in the kidney, was found to be defective in tubulo-interstitial samples dissected out in kidney biopsies from patients with chronic kidney disease (CKD). Experimental data indicated that this decrease was a strong determinant of renal fibrogenesis, hence a focus for therapeutic interventions. Nevertheless, whether persistently differentiated renal tubules, surviving in a pro-fibrotic environment, also suffer from a decrease in FAO, is currently unknown...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929182/long-term-evaluation-of-community-health-promotion-using-capacity-building-as-an-intermediate-outcome-measure
#3
S Nickel, W Süß, C Lorentz, A Trojan
OBJECTIVES: Between 2001 and 2012, the health authority of Hamburg-Eimsbüttel carried out a health promotion programme for children and their parents in a disadvantaged neighbourhood called Lenzsiedlung. The programme consisted of different action fields aiming at sustainable establishment of community capacities. STUDY DESIGN: The research goal was the long-term assessment of community capacities with a newly developed instrument 'KEQ' (KEQ = Kapazitätsentwicklung im Quartier/capacity building in small areas/neighbourhoods)...
June 18, 2018: Public Health
https://www.readbyqxmd.com/read/29929174/lacosamide-efficacy-and-tolerability-in-clinical-practice-post-marketing-analysis-from-a-single-dedicated-epilepsy-center
#4
Mark D Baker, Bassel W Abou-Khalil, Amir Arain, Pavan Tummala, Nabil J Azar, Kevin F Haas, Hasan H Sonmezturk
OBJECTIVES: Post marketing analysis of anti-epileptic drug (AED) efficacy and tolerability is of great value to the clinician since it is more representative of clinical practice than clinical trial data. We analyzed our experience with lacosamide (LCM) in patients treated after marketing. PATIENTS AND METHODS: We identified all patients who were treated with LCM during the four year period after marketing, excluding patients who were in clinical trials. We recorded demographic data and analyzed efficacy and tolerability in patients who had at least one follow up visit or telephone call 3 months after the initiation of LCM...
June 13, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29929173/influence-of-tranexamic-acid-on-cerebral-hemorrhage-a-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
Beilei Huang, Qiusheng Xu, Ru Ye, Jun Xu
Tranexamic acid might be beneficial for cerebral hemorrhage. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the influence of tranexamic acid on cerebral hemorrhage. PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of tranexamic acid on cerebral hemorrhage were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies...
June 12, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29929153/pain-and-anxiety-and-their-relationship-with-medication-doses-in-the-intensive-care-unit
#6
Sunyoung Park, Se Hee Na, Jooyoung Oh, Jong Seok Lee, Seung-Taek Oh, Jae-Jin Kim, Jin Young Park
PURPOSE: Pain and anxiety are understudied despite their importance to the general medical condition. The aim of the present study was to examine the effects of pain and anxiety and their relationship to the doses of opioids and anxiolytics administered in intensive care unit (ICU) patients. METHODS: The subjects included 1349 conscious, critically ill patients admitted to an ICU. Psychiatrists evaluated the patients daily for pain and anxiety. Data regarding the doses of opioids and benzodiazepines administered were gathered...
June 2, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29929135/modeling-the-effect-of-adsorption-on-the-degradation-rate-of-propiconazole-in-profiles-of-polish-luvisols
#7
Tadeusz Paszko, Monika Jankowska
Laboratory adsorption and degradation studies were carried out to determine the effect of time-dependent adsorption on propiconazole degradation rates in samples from three Polish Luvisols. Strong propiconazole adsorption (organic carbon normalized adsorption coefficients Koc in the range of 1217-7777 mL/g) was observed in batch experiments, with a typical biphasic mechanism with a fast initial step followed by the time-dependent step, which finished within 48 h in the majority of soils. The time-dependent step observed in incubation experiments was longer (duration from 5 to 23 d), and its contribution to total adsorption was from 20% to 34%...
June 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29929086/positive-and-negative-social-support-and-hpa-axis-hyperactivity-evidence-from-glucocorticoids-in-human-hair
#8
Eleonora Iob, Clemens Kirschbaum, Andrew Steptoe
INTRODUCTION: While positive social support is associated with lower prevalence of disease and better treatment outcomes, negative social relationships can instead have unfavourable consequences for several physical and mental health conditions. However, the specific mechanisms by which this nexus might operate remain poorly understood. Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity owing to psychosocial stress has been proposed as a potential pathway underlying the link between social support and health...
June 12, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29929076/updating-energy-security-and-environmental-policy-energy-security-theories-revisited
#9
L Proskuryakova
The energy security theories are based on the premises of sufficient and reliable supply of fossil fuels at affordable prices in centralized supply systems. Policy-makers and company chief executives develop energy security strategies based on the energy security theories and definitions that dominate in the research and policy discourse. It is therefore of utmost importance that scientists revisit these theories in line with the latest changes in the energy industry: the rapid advancement of renewables and smart grid, decentralization of energy systems, new environmental and climate challenges...
June 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29929069/a-novel-electron-microscopic-method-for-measurement-of-mineral-content-in-enamel-lesions
#10
C Fowler, R J M Lynch, D Shingler, D Walsh, C Carson, A Neale, R J Willson, A Brown
OBJECTIVE: To assess Scanning Electron Microscopy in Back-Scattered Emission mode (BSE-SEM) for measurement of lesion mineral content as a function of depth. Direct comparison is made with Transverse Micro-Radiography (TMR) and Surface Micro-Hardness (SMH) on carious and erosive lesions. DESIGN: Caries lesions prepared from sound bovine enamel at 37 °C and pH 4.6 in unsaturated (7d) or part-saturated (8d, 4.1 mM Ca2+ , 8 mM Pi) lactic acid /methyl cellulose gel system, followed by TMR analysis...
June 13, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29929059/evaluation-of-forensic-genetics-findings-given-activity-level-propositions-a-review
#11
REVIEW
Duncan Taylor, Bas Kokshoorn, Alex Biedermann
The evaluation of results of forensic genetic analyses given activity level propositions is an emerging discipline in forensic genetics. Although it is a topic with a long history, it has never been considered to be such a critically important topic for the field, as today. With the increasing sensitivity of analysis techniques, and advances in data interpretation using probabilistic models ('probabilistic genotyping'), there is an increasing demand on forensic biologists to share specialised knowledge to help recipients of expert information address mode and timing of transfer and persistence of traces in court...
June 7, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29929053/curvelet-transform-based-volume-fusion-for-correcting-signal-loss-artifacts-in-time-of-flight-magnetic-resonance-angiography-data
#12
Ahmadreza Baghaie, Susanne Schnell, Ali Bakhshinejad, Mojtaba F Fathi, Roshan M D'Souza, Vitaliy L Rayz
Flow fields in cerebral aneurysms can be measured in vivo with phase-contrast MRI (4D Flow MRI), providing 3D anatomical magnitude images as well as 3-directional velocities through the cardiac cycle. The low spatial resolution of the 4D Flow MRI data, however, requires the images to be co-registered with higher resolution angiographic data for better segmentation of the blood vessel geometries to adequately quantify relevant flow descriptors such as wall shear stress or flow residence time. Time-of-Flight Magnetic Resonance Angiography (TOF MRA) is a non-invasive technique for visualizing blood vessels without the need to administer contrast agent...
June 15, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29929047/isolated-hypospadias-the-impact-of-prenatal-exposure-to-pesticides-as-determined-by-meconium-analysis
#13
Elodie Haraux, Pierre Tourneux, Christelle Kouakam, Erwan Stephan-Blanchard, Bernard Boudailliez, Andre Leke, Celine Klein, Karen Chardon
Although endocrine-disrupting chemicals (EDCs, including pesticides) are thought to increase the risk of hypospadias, no compounds have been formally identified in this context. Human studies may now be possible via the assessment of meconium as a marker of chronic prenatal exposure. The objective of the present study was to determine whether or not prenatal exposure to pesticides (as detected in meconium) constitutes a risk factor for isolated hypospadias. In a case-control study performed between 2011 and 2014 in northern France, male newborns with isolated hypospadias (n = 25) were matched at birth with controls (n = 58)...
June 18, 2018: Environment International
https://www.readbyqxmd.com/read/29929043/mutations-in-the-neuroblastoma-amplified-sequence-gene-in-a-family-affected-by-acrofrontofacionasal-dysostosis-type-1
#14
Eleonora Palagano, Giulia Zuccarini, Paolo Prontera, Renato Borgatti, Gabriela Stangoni, Sandro Elisei, Stefano Mantero, Ciro Menale, Antonella Forlino, Paolo Uva, Manuela Oppo, Paolo Vezzoni, Anna Villa, Giorgio R Merlo, Cristina Sobacchi
Acrofrontofacionasal Dysostosis type 1 (AFFND1) is an extremely rare, autosomal recessive syndrome, comprising facial and skeletal abnormalities, short stature and intellectual disability. We analyzed an Indian family with two affected siblings by exome sequencing and identified a novel homozygous truncating mutation in the Neuroblastoma-Amplified Sequence (NBAS) gene in the patients' genome. Mutations in the NBAS gene have recently been associated with different phenotypes mainly involving skeletal formation, liver and cognitive development...
June 18, 2018: Bone
https://www.readbyqxmd.com/read/29929040/global-analysis-of-ubiquitome-in-prrsv-infected-pulmonary-alveolar-macrophages
#15
Huan Zhang, Liurong Fang, Xinyu Zhu, Dang Wang, Shaobo Xiao
Protein lysine ubiquitination is a dynamic reversible post-translational modification that plays key roles in modulating different cellular processes. Porcine reproductive and respiratory syndrome virus (PRRSV) is a notorious pathogen, causing tremendous economic losses for the global swine industry. The possible involvement of ubiquitination in PRRSV infection is unclear. So anti-ubiquitination-based enrichment and LC-MS were performed to investigate the global ubiquitination events triggered by PRRSV infection in pulmonary alveolar macrophages...
June 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29929026/surgical-treatment-of-middle-cerebral-artery-aneurysms-the-aneurysm-location-and-size-ratio-as-risk-factors-for-the-neurological-worsening-and-ischemic-complications
#16
Hidetoshi Matsukawa, Hiroyasu Kamiyama, Takanori Miyazaki, Yu Kinoshita, Nakao Ota, Kosumo Noda, Takaharu Shonai, Osamu Takahashi, Sadahisa Tokuda, Rokuya Tanikawa
OBJECT: Regardless of acceptable surgical results of middle cerebral artery aneurysms (MCAs), MCA territory infarction (MCATI) is still one of major problems needing to be solved to archive the better outcome. Authors aimed to investigate the MCATI in patients with surgically treated MCA aneurysms. METHODS: The data of 286 consecutive patients with 322 MCA aneurysms was retrospectively evaluated. The aneurysm location was classified into the early frontal cortical branch (EFCB), early temporal cortical branch (ETCB), bi- or trifurcation (M1-2), and distal aneurysms on the insular, opercular, or cortical segments of MCA (distal MCA)...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929001/carriage-of-blastocystis-spp-in-travellers-a-prospective-longitudinal-study
#17
Jarne M van Hattem, Maris S Arcilla, Constance Schultsz, Martin C Bootsma, Nienke Verhaar, Sjoerd P Rebers, Abraham Goorhuis, Martin P Grobusch, John Penders, Menno D de Jong, Tom van Gool, Aldert Bart
INTRODUCTION: A lack of prospective and longitudinal data on pre- and post-travel carriage of Blastocystis spp. complicates interpretation of a positive test post-travel. Therefore we studied dynamics of Blastocystis carriage in a cohort of Dutch travellers. METHODS: From the prospective, multicentre COMBAT study among 2001 Dutch travellers, a subset of 491 travellers was selected based on travel destination to 7 subregions (70 or 71 travellers each). Faecal samples taken directly before and after travel were screened for Blastocystis with qPCR, followed, when positive, by sequence analysis to determine subtypes...
June 18, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29928977/the-melas-mutation-m-3243a-g-promotes-reactivation-of-fetal-cardiac-genes-and-an-epithelial-mesenchymal-transition-like-program-via-dysregulation-of-mirnas
#18
Salvador Meseguer, Joaquin Panadero, Carmen Navarro-González, Magda Villarroya, Rachid Boutoual, Giacomo Pietro Comi, M-Eugenia Armengod
The pathomechanisms underlying oxidative phosphorylation (OXPHOS) diseases are not well-understood, but they involve maladaptive changes in mitochondria-nucleus communication. Many studies on the mitochondria-nucleus cross-talk triggered by mitochondrial dysfunction have focused on the role played by regulatory proteins, while the participation of miRNAs remains poorly explored. MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is mostly caused by mutation m.3243A>G in mitochondrial tRNALeu(UUR) gene...
June 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29928972/metabolic-profiling-and-correlation-analysis-for-the-determination-of-killer-compounds-of-proliferating-and-clonogenic-hrt-18-colon-cancer-cells-from-lafoensia-pacari
#19
Cristiane Loiva Reichert, Denise Brentan da Silva, Carlos Alexandre Carollo, Almeriane Maria Weffort-Santos, Cid Aimbiré de Moraes Santos
ETHNOPHARMACOLOGICAL RELEVANCE: Lafoensia pacari A. St.-Hil., belonging to the family Lythraceae and popularly known as 'dedaleira' and 'mangava-brava,' is a native tree of the Brazilian Cerrado, and its barks have been traditionally used as a tonic to treat inflammatory conditions, particularly related to gastric ulcers, wounds or fevers and various types of cancer. AIM OF THE STUDY: We have previously demonstrated the apoptogenic effects of the methanolic extract of L...
June 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29928963/replication-and-reproducibility-issues-in-the-relationship-between-c-reactive-protein-and-depression-a-systematic-review-and-focused-meta-analysis
#20
REVIEW
Sarah R Horn, Madison M Long, Benjamin W Nelson, Nicholas B Allen, Philip A Fisher, Michelle L Byrne
One of the most common inflammatory markers examined in depression is C-reactive protein (CRP). However, the magnitude of the association between CRP and depression when controlling for potentially confounding factors such as age, sex, socio-economic status, body mass index, medication and other substance use, and medical illness, is unclear. Inconsistencies in other methodological practices, such as sample collection, assaying, and data cleaning and transformation, may contribute to variations in results. We aggregate studies that examined the association between CRP and depression in two ways...
June 18, 2018: Brain, Behavior, and Immunity
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