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https://www.readbyqxmd.com/read/29233030/hydrodynamic-cavitation-as-a-strategy-to-enhance-the-efficiency-of-lignocellulosic-biomass-pretreatment
#1
Ruly Terán Hilares, Lucas Ramos, Silvio Silvério da Silva, Giuliano Dragone, Solange I Mussatto, Júlio César Dos Santos
Hydrodynamic cavitation (HC) is a process technology with potential for application in different areas including environmental, food processing, and biofuels production. Although HC is an undesirable phenomenon for hydraulic equipment, the net energy released during this process is enough to accelerate certain chemical reactions. The application of cavitation energy to enhance the efficiency of lignocellulosic biomass pretreatment is an interesting strategy proposed for integration in biorefineries for the production of bio-based products...
December 12, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29231756/higher-levels-of-circulating-timp-4-in-preeclampsia-is-strongly-associated-with-clinical-parameters-and-microrna
#2
Valéria C Sandrim, Solange Diniz, Nibia Mariana Eleuterio, Karina B Gomes, Luci Maria S Dusse, Ricardo C Cavalli
BACKGROUND: Preeclampsia results in maternal and fetal complications and some studies have reported the role of MMPs and TIMPs in its pathophysiology. Therefore, the aim of this study was to compare plasma TIMP-4 levels in preeclampsia and healthy pregnant; and to correlate these levels with clinical parameters and expression of Let7a-5p (3´UTR post-transcriptionally regulation) Methods: TIMP-4 was measured by ELISA and miR-Let7a-5p expression by qPCR. RESULTS: Elevated plasma TIMP-4 levels in preeclampsia compared to healthy pregnant was found 1450 ± 411 vs...
December 12, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29225840/severe-thyrotoxicosis-in-an-infant-revealing-familial-nonautoimmune-hyperthyroidism-with-a-novel-c672w-stimulating-thyrotropin-receptor-germline-mutation
#3
Isabelle Oliver-Petit, Frédérique Savagner, Solange Grunenwald, Magaly Vialon, Thomas Edouard, Philippe Caron
We describe severe thyrotoxicosis in young members of a family with nonautoimmune hyperthyroidism caused by a C672W germline mutation in exon 10 of TSHR gene. In this family, lack of genotype-phenotype correlation and anticipation across generations could be linked to an increased iodine intake as recently observed in France.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29223537/rankl-signaling-sustains-primary-tumor-growth-in-genetically-engineered-mouse-models-of-lung-adenocarcinoma
#4
Julien Faget, Caroline Contat, Nadine Zangger, Solange Peters, Etienne Meylan
HYPOTHESIS: Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality. Recent retrospective clinical analyses suggest that blocking the receptor activator of NF-κB (RANK) signaling pathway inhibits the growth of NSCLC and might represent a new treatment strategy. METHODS: RANK and RANKL expression in human lung adenocarcinoma was interrogated from publicly available gene expression datasets. Several genetically engineered mouse models were used to evaluate treatment efficacy of RANK-Fc to block RANKL, with primary tumor growth measured longitudinally using micro-computed tomography...
December 6, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29223108/impacts-of-sugarcane-agriculture-expansion-over-low-intensity-cattle-ranch-pasture-in-brazil-on-greenhouse-gases
#5
Camila Bolfarini Bento, Solange Filoso, Leonardo Machado Pitombo, Heitor Cantarella, Raffaella Rossetto, Luiz Antonio Martinelli, Janaina Braga do Carmo
Sugarcane is a widespread bioenergy crop in tropical regions, and the growing global demand for renewable energy in recent years has led to a dramatic expansion and intensification of sugarcane agriculture in Brazil. Currently, extensive areas of low-intensity pasture are being converted to sugarcane, while management in the remaining pasture is becoming more intensive, i.e., includes tilling and fertilizer use. In this study, we assessed how such changes in land use and management practices alter emissions of greenhouse gases (GHG) such as CO2, N2O and CH4 by measuring in situ fluxes for one year after conversion from low-intensity pasture to conventional sugarcane agriculture and management-intensive pasture...
December 6, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29202086/strategies-and-governance-to-reduce-health-inequalities-evidences-from-a-cross-european-survey
#6
Sara Barsanti, Louis-Rachid Salmi, Yann Bourgueil, Antonio Daponte, Ewelina Pinzal, Solange Ménival
Background: The main objective of the paper is to identify the governance system related to policies to reduce health inequalities in the European regions. Considering the Action Spectrum of inequalities and the check list of health equity governance, we developed a survey in the framework of the AIR Project - Addressing Inequalities Intervention in Regions - was an European project funded by the Executive Agency of Health and Consumers. Methods: A web-based qualitative questionnaire was developed that collected information about practiced strategies to reduce health inequalities...
2017: Global Health Research and Policy
https://www.readbyqxmd.com/read/29193137/fatal-toxoplasmosis-in-a-southern-muriqui-brachyteles-arachnoides-from-s%C3%A3-o-paulo-state-brazil-pathological-immunohistochemical-and-molecular-characterization
#7
Stéfanie Vanessa Santos, Hilda F J Pena, Mauricio T Gomes, Rodrigo H F Teixeira, Cristina T Kanamura, Josué Diaz-Delgado, Solange M Gennari, José Luiz Catão-Dias
We report the pathological, immunohistochemical, and molecular features of fatal acute systemic toxoplasmosis in an adult, female, free-living southern muriqui (Brachyteles arachnoides) from São Paulo state, Brazil. PCR-RFLP genotyping analysis identified the #21 genotype of Toxoplasma gondii. This represents the first report of acute toxoplasmosis involving this genotype in humans and animals.
November 29, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/29191776/evaluation-of-ngs-and-rt-pcr-methods-for-alk-rearrangement-in-european-nsclc-patients-results-from-the-etop-lungscape-project
#8
Igor Letovanec, Stephen Finn, Panagiota Zygoura, Paul Smyth, Alex Soltermann, Lukas Bubendorf, Ernst-Jan Speel, Antonio Marchetti, Daisuke Nonaka, Kim Monkhorst, Henrik Hager, Miguel Martorell, Aleksandra Sejda, Richard Cheney, Javier Hernandez-Losa, Eric Verbeken, Walter Weder, Spasenija Savic, Alessia Di Lorito, Atilio Navarro, Enriqueta Felip, Arne Warth, Paul Baas, Peter Meldgaard, Fiona Blackhall, Anne-Marie Dingemans, Hendrik Dienemann, Rafal Dziadziuszko, Johan Vansteenkiste, Cathal O'Brien, Thomas Geiger, Jon Sherlock, Jeoffrey Schageman, Urania Dafni, Roswitha Kammler, Keith Kerr, Erik Thunnissen, Rolf Stahel, Solange Peters
INTRODUCTION: The reported prevalence of ALK rearrangement in NSCLC ranges from 2%-7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proven to be a reproducible and sensitive technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) has also been advocated and most recently the advent of targeted Next-Generation Sequencing (NGS) for ALK and other fusions has become possible. This study compares ALK evaluation with all 4 techniques in resected NSCLC from the large ETOP Lungscape cohort...
November 27, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29177980/cardiac-autonomic-responses-and-number-of-repetitions-maximum-after-led-irradiation-in-the-ipsilateral-and-contralateral-lower-limb
#9
Adalberto Ferreira Junior, Julio Cezar Schamne, Solange Marta Franzói de Moraes, Nilo Massaru Okuno
The aim of this study was to verify the maximum number of repetitions, fatigue index, blood lactate concentration ([Lac]), and cardiac autonomic responses after LED irradiation (LEDI) in the ipsilateral and contralateral limb. Twelve male subjects (22.0 ± 3.86 years; weight 82.94 ± 12.58 kg; height 1.77 ± 0.05 m), physically active, took part in this study. The subjects underwent a one repetition maximum (1RM) test and performed four randomly experimental sessions in the horizontal leg press exercise, which consisted in four sets of maximum repetitions at 80% of 1RM...
November 24, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29169873/modified-hypercvad-versus-bortezomib-hypercad-in-patients-with-relapsed-refractory-multiple-myeloma
#10
Megan M Saraceni, Emma Scott, Richard T Maziarz, Matthew B Siegel, Solange Bassale, Susie Jiing, Eva Medvedova
INTRODUCTION: Multiple myeloma (MM) is an incurable plasma cell malignancy, in which aggressive relapses might require salvage cytotoxic infusional chemotherapy. Several clinical trials that reported the efficacy of bortezomib led to institutional practice changes in which vincristine was replaced with bortezomib in the modified hyperCVAD regimen, creating a new treatment regimen, named "bortezomib-hyperCAD." PATIENTS AND METHODS: We retrospectively describe the effectiveness and tolerability of 2 chemotherapy regimens among 33 patients with relapsed and/or refractory MM...
November 2, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29168181/different-il-17-secreting-tlr-t-cell-subsets-are-associated-with-disease-activity-in-multiple-sclerosis
#11
Thais B Ferreira, Joana Hygino, Ana Cristina Wing, Taissa M Kasahara, Priscila M Sacramento, Solange Camargo, Fernanda Rueda, Soniza V Alves-Leon, Regina Alvarenga, Claudia Cristina Vasconcelos, Anshu Agrawal, Sudhir Gupta, Cleonice A M Bento
Signaling through toll-like receptors (TLRs) may play a role in the pathogenesis of autoimmune diseases, such as multiple sclerosis (MS). In the present study, the expression of TLR2, TLR4 and TLR9 was significantly higher on CD4(+) and CD8(+) T cells from MS patients as compared to healthy individuals. Following in vitro activation, the proportion of IL-17+ and IL-6+ CD4+ and CD8+ T cells was higher in the patients. In addition, the proportion of IFN-γ-secreting TLRs(+) CD8(+) T cells was increased in MS patients...
November 23, 2017: Immunology
https://www.readbyqxmd.com/read/29163795/oral-4-n-stearoyl-gemcitabine-nanoparticles-inhibit-tumor-growth-in-mouse-models
#12
Caixia Wang, Yuanqiang Zheng, Michael A Sand Oval, Solange A Valdes, Zhe Chen, Dharmika S Lansakara-P, Maolin Du, Yanchun Shi, Zhengrong Cui
In spite of recent advances in targeted tumor therapy, systemic chemotherapy with cytotoxic agents remains a vital cancer treatment modality. Gemcitabine is a nucleoside analog commonly used in the treatment of various solid tumors, but an oral gemcitabine dosage form remain unavailable. Previously, we developed the 4-(N)-stearoyl gemcitabine solid lipid nanoparticles (GemC18-SLNs) by incorporating 4-(N)-stearoyl gemcitabine (GemC18), an amide prodrug of gemcitabine, into solid lipid nanoparticles. GemC18-SLNs, when administered intravenously, showed strong antitumor activity against various human and mouse tumors in mouse models...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156447/pd-1-blockade-in-advanced-nsclc-a-focus-on-pembrolizumab
#13
REVIEW
Solange Peters, Keith M Kerr, Rolf Stahel
Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers and is responsible for a large proportion of all cancer-related deaths. Current treatment options are inadequate, reflecting a substantial unmet clinical need. Increasing knowledge regarding the mechanisms and genetic aberrations underlying tumor development and growth has heralded a new era of therapy in oncology, moving away from indiscriminate cytotoxic chemotherapy toward more finely focused, targeted medicine. The development of small-molecule drugs and monoclonal antibodies directed toward specific components of dysfunctional molecular or immune pathways, and mutated genes specific to particular cancer types, is leading the field to more personalized and less toxic treatment options, many of which have demonstrated greater efficacy and survival benefits than their chemotherapeutic counterparts...
October 23, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29155361/silver-nanoparticles-increase-bactericidal-activity-and-radical-oxygen-responses-against-bacterial-pathogens-in-human-osteoclasts
#14
Valerie Aurore, Fabienne Caldana, Marianne Blanchard, Solange Kharoubi Hess, Nils Lannes, Pierre-Yves Mantel, Luis Filgueira, Michael Walch
Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are not well equipped for killing bacteria and may serve as a reservoir for bacterial pathogens. Silver has been known for centuries for its bactericidal activity. Here, we investigated the bactericidal effects of nano-silver particles in bacteria infected human osteoclasts...
November 16, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29155337/photodynamic-therapy-in-fibrosarcoma-balb-c-animal-model-observation-of-the-rebound-effect
#15
Etcheverry María Eugenia, Pasquale Miguel Ángel, Gutiérrez Anabella, Bibé Solange, Ponzinibbio Carlos, Poteca Horacio, Garavaglia Mario
In vivo spectrofluorometric analysis during photodynamic therapy (PDT) is a fundamental tool to obtain information about the drug bleaching kinetics. Using a portable spectrofluorometer with an excitation source emitting at 400nm wavelength and a spectral analyzer ranging from 500nm to 800nm, the evolution of the meta-tetra(hydroxyphenyl) chlorin (m-THPC) photosensitizer fluorescence spectrum at the tumoral tissue of BALB/c murines with fibrosarcoma located at their flank was followed up. Ex vivo fluorescence measurements of the tumor and skin were also performed with the aim of better characterizing the in vivo signal at different parts of the tumor...
November 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29148957/aerobic-exercise-training-performed-by-parents-reduces-mice-offspring-adiposity
#16
Paulo Vitor da Silva Romero, Débora Alves Guariglia, Francielli Ferreira Da Rocha, Caroline de Carvalho Picoli, Gustavo Renan Gilio, Gabriel Sergio Fabricio, Paulo Cesar de Freitas Mathias, Solange Marta Franzói de Moraes, Sidney Barnabé Peres
The present study aimed to determine the effects of physical training performed by parents on mice offspring adiposity. Male and female parents underwent an aerobic training protocol for 7 weeks. The trained and sedentary parents were allowed to mate and the resultant offspring divided in: S (Offspring from Sedentary Parents), T (Offspring from Trained Parents), ST (Offspring from Sedentary Father and Trained Mother) and TS (Offspring from Trained Father and Sedentary Mother). After weaning, offspring was euthanized, blood collected and samples of mesenteric and inguinal fat pads used to isolate adipocytes for morphologic and histological analyses...
November 17, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29144172/disruptions-in-sleep-wake-cycles-in-community-dwelling-cancer-patients-receiving-palliative-care-and-their-correlates
#17
Marie Solange Bernatchez, Josée Savard, Hans Ivers
Significant disruptions in sleep-wake cycles have been found in advanced cancer patients in prior research. However, much remains to be known about specific sleep-wake cycle variables that are impaired in patients with a significantly altered performance status. More studies are also needed to explore the extent to which disrupted sleep-wake cycles are related to physical and psychological symptoms, time to death, maladaptive sleep behaviors, quality of life and 24-h light exposure. This study conducted in palliative cancer patients was aimed at characterizing patients' sleep-wake cycles using various circadian parameters (i...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29141165/immunotherapy-for-unresectable-stage-iii-non-small-cell-lung-cancer
#18
EDITORIAL
Naiyer A Rizvi, Solange Peters
New England Journal of Medicine, Volume 377, Issue 20, Page 1986-1988, November 2017.
November 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29128335/hereditary-angioedema-with-normal-c1-inhibitor-and-f12-mutations-in-42-brazilian-families
#19
Camila Lopes Veronez, Adriana S Moreno, Rosemeire Navickas Constantino-Silva, Luana S M Maia, Mariana P L Ferriani, Fábio F M Castro, Solange Rodrigues Valle, Victor Koji Nakamura, Nathália Cagini, Rozana Fátima Gonçalves, Eli Mansour, Faradiba Sarquis Serpa, Gabriela Andrade Coelho Dias, Miguel Alberto Piccirillo, Eliana Toledo, Marli de Souza Bernardes, Sven Cichon, Christiane Stieber, L Karla Arruda, João Bosco Pesquero, Anete Sevciovic Grumach
BACKGROUND: Hereditary angioedema (HAE) with normal C1 inhibitor (C1-INH) is a rare condition with clinical features similar to those of HAE with C1-INH deficiency. Mutations in the F12 gene have been identified in subsets of patients with HAE with normal C1-INH, mostly within families of European descent. OBJECTIVES: Our aim was to describe clinical characteristics observed in Brazilians from 42 families with HAE and F12 gene mutations (FXII-HAE), and to compare these findings with those from other populations...
November 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29128272/cytoprotection-of-lipoic-acid-against-toxicity-induced-by-saxitoxin-in-hippocampal-cell-line-ht-22-through-in-silico-modeling-and-in-vitro-assays
#20
Patrícia Ramos, Marcos Schmitz, Sibele Gama, Aline Portantiolo, Michael Gonzalez Durruthy, Ana Paula de Souza Votto, Luisa Rodrigues Cornetet, Karina Dos Santos Machado, Adriano Wehrli, Mariana Zancan Tonel, Solange Binotto Fagan, João Sarkis Yunes, José Maria Monserrat
Saxitoxins (STXs) are potent neurotoxins that block voltage-gated channels in neurons and induce cytotoxicity. These toxins not only can generate reactive oxygen species but also can alter antioxidant levels, promoting oxidative stress. Under this pro-oxidant situation, the use of the antioxidant lipoic acid (LA) can represent a chemoprotective alternative to minimize the deleterious effects induced by neurotoxins as STXs. P-glycoprotein (P-gp) is a well-known ATP-binding cassette (ABC) transporter that plays a crucial role in the extrusion of toxic substances, decreasing their accumulation and potential intracellular effects in virtue of its broad substrate specificity, its expression in many excretory tissues and its large efflux capacity...
November 8, 2017: Toxicology
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