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vitamin d premature rupture

Song Yi Kook, Kyo Hoon Park, Ji Ae Jang, Yu Mi Kim, Hyunsoo Park, Se Jeong Jeon
OBJECTIVE: To determine whether vitamin D-binding protein (VDBP) in cervicovaginal fluid (CVF) is independently predictive of intra-amniotic infection and imminent spontaneous preterm delivery (SPTD, delivery within 48 hours) in women with preterm labor with intact membranes (PTL) or preterm premature rupture of membranes (PPROM). METHOD: This was a single-center retrospective cohort study. CVF samples for VDBP assays were obtained along with serum C-reactive protein (CRP) levels immediately after amniocentesis in consecutive women with PTL (n = 148) or PPROM (n = 103) between 23...
2018: PloS One
Maria Manuel Costa, Sandra Belo, Pedro Souteiro, João S Neves, Daniela Magalhães, Rita B Silva, Sofia C Oliveira, Paula Freitas, Ana Varela, Joana Queirós, Davide Carvalho
AIM: We aimed to evaluate the impact of bariatric surgery (BS) on maternal and fetal outcomes. METHODS: A retrospective, descriptive, observational study of 39 pregnant women who underwent BS in our institution between 2010 and 2014 was carried out. A sample of women who became pregnant after BS was evaluated, based on data concerning pregnancy, childbirth, and newborns. RESULTS: Of the 1182 patients who underwent BS at our institution during the study period, 1016 (85...
April 2018: Journal of Obstetrics and Gynaecology Research
Sook-Hyun Park, Gi-Min Lee, Jung-Eun Moon, Heng-Mi Kim
PURPOSE: We investigated the vitamin D status of preterm infants to determine the incidence of vitamin D deficiency. METHODS: A total of 278 preterm infants delivered at Kyungpook National University Hospital between January 2013 and May 2015 were enrolled. The serum concentrations of calcium, phosphorous, alkaline phosphatase, and 25-hydroxyvitamin D (25-OHD) were measured at birth. We collected maternal and neonatal data such as maternal gestational diabetes, premature rupture of membranes, maternal preeclampsia, birth date, gestational age, and birth weight...
November 2015: Korean Journal of Pediatrics
J Zhou, L Su, M Liu, Y Liu, X Cao, Z Wang, H Xiao
BACKGROUND/OBJECTIVES: Observational studies relating 25-hydroxyvitamin D (25(OH)D) and pregnancy outcomes have reported conflicting results. The aim was to assess maternal 25(OH)D status and its association with pregnancy outcomes. A prospective observational study was carried out in Guangzhou city (23 ºN), China. SUBJECTS/METHODS: Pregnant women (n=2960) and healthy controls (n=100) were recruited at a teaching hospital. Maternal 25(OH)D levels were measured at 16-20-week gestation...
August 2014: European Journal of Clinical Nutrition
Michel A Makhlouf, Rebecca G Clifton, James M Roberts, Leslie Myatt, John C Hauth, Kenneth J Leveno, Michael W Varner, John M Thorp, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Jay D Iams, Anthony Sciscione, Jorge E Tolosa, Yoram Sorokin
OBJECTIVE: The aim of the article is to determine whether prior spontaneous abortion (SAB) or induced abortion (IAB), or the interpregnancy interval are associated with subsequent adverse pregnancy outcomes in nulliparous women. METHODS: We performed a secondary analysis of data collected from nulliparous women enrolled in a completed trial of vitamins C and E or placebo for preeclampsia prevention. Adjusted odds ratios (ORs) for maternal and fetal outcomes were determined for nulliparous women with prior SABs and IABs as compared with primigravid participants...
October 2014: American Journal of Perinatology
Stella Liong, Megan K W Di Quinzio, Yujing J Heng, Gabrielle Fleming, Michael Permezel, Gregory E Rice, Harry M Georgiou
A significant obstetric complication facing contemporary materno-fetal medicine is preterm premature rupture of the fetal membranes (preterm PROM), which occurs in 30% of all preterm births. The objective of this study was to identify differentially expressed proteins in the cervicovaginal fluid of asymptomatic women before the clinical manifestation of preterm PROM. The preterm PROM group comprised of women with samples collected 6-23 days before PROM, who subsequently delivered preterm (n=5). Women who spontaneously delivered at term served as gestation-matched controls (n=10)...
February 2013: Reproduction: the Official Journal of the Society for the Study of Fertility
Daphna K Dror, Lindsay H Allen
The water-soluble vitamins B6, B12 and C play important roles in maternal health as well as fetal development and physiology during gestation. This systematic review evaluates the risks and benefits of interventions with vitamins B6, B12 and C during pregnancy on maternal, neonatal and child health and nutrition outcomes. Relevant publications were identified by searching PubMed, Popline and Web of Science databases. Meta-analyses were conducted for outcomes where results from at least three controlled trials were available...
July 2012: Paediatric and Perinatal Epidemiology
Sunethra Devika C Thomas, Andrew N Fudge, Malcolm Whiting, Penelope S Coates
BACKGROUND: Although vitamin D insufficiency is prevalent in the community, only a few population-based studies have measured serum 25-hydroxy-vitamin D (25OHD) levels during pregnancy and in newborns. Maternal vitamin D deficiency has been linked to pregnancy complications, as well as hypocalcaemia and rickets in the newborn. Here, the authors report third-trimester maternal and newborn-serum 25OHD concentrations in 101 neonates whose serum samples were sent for testing. METHODS: The newborn 25OHD levels were correlated with the third-trimester maternal serum 25OHD levels using a least-square regression analysis...
January 1, 2011: BMJ Open
Charles S Algert, Jennifer R Bowen, Samantha L Lain, Hugh D Allen, Josephine M Vivian-Taylor, Christine L Roberts
BACKGROUND: There is increasing interest in the potential for in utero exposures to affect the risk of asthma. We used population data to explore the associations between perinatal conditions and the risk of hospital admission with asthma between the 2nd and 5th birthday. METHODS: The study population was 240,511 singleton infants born during 2001-2003. Birth records and longitudinally linked hospital admissions were used to identify asthma admissions and to model potential risk factors...
December 2011: Pediatric Allergy and Immunology
L Blanchon, G Marceau, V Borel, C Prat, A Herbet, D Bouvier, D Gallot, V Sapin
Retinoids (active derivatives of vitamin A) were already demonstrated to be important morphogenes and their implication at the placental and fetal level was already established. A new field of research is now developed in order to show their role on fetal membranes constituted by amnion and chorion. To describe the role of retinoids on these membranes, our studies were focused on target gene research. Firstly, all metabolism enzymes needed to vitamin A pathways were demonstrated to be present and active in signal transduction...
June 2011: Gynécologie, Obstétrique & Fertilité
John C Hauth, Rebecca G Clifton, James M Roberts, Catherine Y Spong, Leslie Myatt, Kenneth J Leveno, Gail D Pearson, Michael W Varner, John M Thorp, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Anthony Sciscione, Margaret Harper, Jorge E Tolosa, George Saade, Yoram Sorokin, Garland B Anderson
OBJECTIVE: To estimate whether maternally administered vitamins C and E lower the risk of spontaneous preterm birth. METHODS: This is a secondary analysis of a randomized, double-masked, placebo-controlled trial in nulliparous women at low-risk administered 1,000 mg vitamin C and 400 international units vitamin E or placebo daily from 9 to 16 weeks of gestation until delivery. Outcomes include preterm birth attributable to premature rupture of membranes (PROM) and total spontaneous preterm births (spontaneous preterm birth attributable to PROM or spontaneous labor)...
September 2010: Obstetrics and Gynecology
Hairong Xu, Ricardo Perez-Cuevas, Xu Xiong, Hortensia Reyes, Chantal Roy, Pierre Julien, Graeme Smith, Peter von Dadelszen, Line Leduc, François Audibert, Jean-Marie Moutquin, Bruno Piedboeuf, Bryna Shatenstein, Socorro Parra-Cabrera, Pierre Choquette, Stephanie Winsor, Stephen Wood, Alice Benjamin, Mark Walker, Michael Helewa, Johanne Dubé, Georges Tawagi, Gareth Seaward, Arne Ohlsson, Laura A Magee, Femi Olatunbosun, Robert Gratton, Roberta Shear, Nestor Demianczuk, Jean-Paul Collet, Shuqin Wei, William D Fraser
OBJECTIVE: We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high- and low-risk women. STUDY DESIGN: In a multicenter randomized controlled trial, women were stratified by the risk status and assigned to daily treatment (1 g vitamin C and 400 IU vitamin E) or placebo. The primary outcome was GH and its adverse conditions. RESULTS: Of the 2647 women randomized, 2363 were included in the analysis...
March 2010: American Journal of Obstetrics and Gynecology
S Borna, H Borna, B Daneshbodie
OBJECTIVE: To determine whether supplementation with vitamins C and E after preterm premature rupture of membranes (PPROM) is associated with an increased latency period. METHODS: In this double-blind, randomized, controlled trial, 60 women with singleton pregnancies of 26 to 34 weeks' duration and PPROM were randomly assigned to vitamin C (500 mg/day) and vitamin E (400 IU/day) or placebo until delivery. All women received 2 doses of betamethasone in the first 24 h after admission as well as broad-spectrum antibiotic prophylaxis...
July 2005: International Journal of Gynaecology and Obstetrics
Esther Casanueva, Carmina Ripoll, Maricruz Tolentino, Rosa Maria Morales, Frania Pfeffer, Pablo Vilchis, Felipe Vadillo-Ortega
BACKGROUND: Vitamin C is involved in the synthesis and degradation of collagen and is important for maintenance of the chorioamniotic membranes. Inadequate availability of ascorbic acid during pregnancy has been proposed as a risk factor for premature rupture of the chorioamniotic membranes (PROM). OBJECTIVE: The objective of the study was to evaluate the effectiveness of 100 mg vitamin C/d in preventing PROM. DESIGN: A controlled double-blind trial was performed...
April 2005: American Journal of Clinical Nutrition
E Casanueva, C Ripoll, C Meza-Camacho, B Coutiño, J Ramírez-Peredo, A Parra
The precise etiologic mechanisms involved in the premature rupture of membranes (PROM) during pregnancy, the main cause of preterm delivery worldwide, are unknown. Previous studies have shown that: (a) the rupture of chorioamniotic membranes is related to an imbalance between synthesis and degradation of collagen induced by the overexpression/activity of various matrix metalloproteinases (MMP); (b) during human labor and delivery the expression of prolactin receptors (PRL-R) increases in chorioamniotic membranes, decidua and placenta; (c) prolactin (PRL) can influence the synthesis of prostaglandins, the expression of some MMP (MMP-2, MMP-9 and decysin) and tissue inhibitors of MMP in general; (d) vitamin C deficiency induces the expression/activity of extracellular MMP and is considered a risk factor for PROM; and (e) vitamin C potentiates the dopamine-mediated inhibition of PRL in rats...
2005: Medical Hypotheses
Peter D Wall, Eva K Pressman, James R Woods
AIM: To discuss the role of oxidant stress in preterm, premature rupture of the membranes (PPROM). RESULTS: There is evidence to suggest that preterm, premature rupture of the membranes occurs secondary to focal collagen damage in the fetal membranes. CONCLUSION: Oxidant stress caused by increased ROS formation and/or antioxidant depletion may disrupt collagen and cause premature membrane rupture. We propose that supplementation with vitamins C and E may synergistically protect the fetal membranes, and decrease the risks of PPROM...
2002: Journal of Perinatal Medicine
T D Myles, R Espinoza, W Meyer, A Bieniarz
The purpose of this study was to evaluate the clinical characteristics and pregnancy outcomes of twin and singleton pregnancies complicated by preterm premature rupture of membranes (PROM) and to compare the groups to evaluate for differences in these areas. In this retrospective study, patients with a gestational age of < 36 weeks admitted between 1993 and 1996 with PROM were evaluated for their clinical characteristics and pregnancy outcomes. Twin and singleton pregnancies were compared and the results were evaluated for significant differences...
May 1997: Journal of Maternal-fetal Medicine
B L Greenberg, R D Semba, P E Vink, J J Farley, M Sivapalasingam, R W Steketee, D M Thea, E E Schoenbaum
OBJECTIVE: To determine whether vitamin A deficiency is associated with maternal-infant HIV transmission among HIV-infected pregnant women in two United States cities. METHODS: Third trimester serum vitamin A levels were evaluated using high-performance liquid chromatography in 133 HIV-infected women who delivered livebirths during May 1986 to May 1994 and whose infants had known HIV infection status. RESULTS: Sixteen per cent (seven out of 44) of the transmitting mothers and 6% (five out of 89) of the non-transmitting mothers had severe vitamin A deficiency (< 0...
March 1997: AIDS
J D Aplin, S Campbell, P Donnai, J B Bard, T D Allen
Collagenous matrix in amnion accounts for most of the dry weight of the tissue and provides its mechanical strength and resistance to rupture. Cell and organ culture techniques have been utilized to study the influence of vitamin C upon the synthesis and deposition of extracellular matrix by cells of normal amnion at term. The cultures have been examined using light and electron microscopy and metabolic labelling. These studies show that both epithelial cells and fibroblasts of the deeper stromal layer are active in the production of fibrillar matrix at this time...
September 1986: Placenta
D Rush, N L Sloan, J Leighton, J M Alvir, D G Horvitz, W B Seaver, G C Garbowski, S S Johnson, R A Kulka, M Holt
The major associations with the Special Supplemental Food Program for Women, Infants, and Children (WIC) in pregnancy were increased intake of protein, iron, calcium, and vitamin C (four of five targeted nutrients) and of energy, magnesium, phosphorus, thiamin, riboflavin, niacin, vitamin B-6, and vitamin B-12; reversal of low weight gain in early pregnancy; smaller fat stores in late pregnancy; reduced frequency of premature rupture of the uterine membranes; larger infant head circumference with no effect on birth weight and length; increased birth weight and head circumference with better program quality; and lower fetal mortality of appreciable but not significant magnitude...
August 1988: American Journal of Clinical Nutrition
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