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https://www.readbyqxmd.com/read/29036779/barriers-to-effective-conversations-regarding-overweight-and-obesity-in-regional-victoria
#1
Kristen M Glenister, Christina Ar Malatzky, Julian Wright
BACKGROUND: General practitioners (GPs) have a crucial role to play in engaging patients in discussions about overweight and obesity. However, such discussions are currently uncommon. The aim of this study was to examine how GPs in rural areas talk about overweight and obesity with their patients, specifically to identify key barriers to effective conversations. METHODS: This study used a qualitative methodology. Semi-structured interviews were conducted with GPs (n = 7) and patients (n = 7) across two rural areas...
October 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29036435/the-wuschel-related-homeobox-5a-ptowox5a-is-involved-in-adventitious-root-development-in-poplar
#2
Jianbo Li, Jin Zhang, Huixia Jia, Bobin Liu, Pei Sun, Jianjun Hu, Lijuan Wang, Mengzhu Lu
Adventitious rooting is an essential step in vegetative propagation. Currently, the mechanism that regulates adventitious root (AR) development in woody plants is poorly understood. This work demonstrates that Populus tomentosa WUSCHEL-related homeobox 5a (PtoWOX5a) transcription factor is involved in AR development in poplar. PtoWOX5a was specifically expressed in the AR tip and lateral root tip during AR and lateral root regeneration from the stem segment. Phenotypic complementation experiments indicated that the PtoWOX5a can functionally complement AtWOX5 in quiescent center (QC) cells...
September 26, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29036294/realityconvert-a-tool-for-preparing-3d-models-of-biochemical-structures-for-augmented-and-virtual-reality
#3
Alexandre Borrel, Denis Fourches
Motivation: There is a growing interest for the broad use of Augmented Reality (AR) and Virtual Reality (VR) in the fields of bioinformatics and cheminformatics to visualize complex biological and chemical structures. AR and VR technologies allow for stunning and immersive experiences, offering untapped opportunities for both research and education purposes. However, preparing 3D models ready to use for AR and VR is time-consuming and requires a technical expertise that severely limits the development of new contents of potential interest for structural biologists, medicinal chemists, molecular modellers and teachers...
August 2, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29035859/gastrointestinal-nematodes-infections-and-anthelmintic-resistance-in-grazing-sheep-in-the-eastern-inner-mongolia-in-china
#4
Tianlong Han, Min Wang, Guanghe Zhang, Dongsheng Han, Xinwei Li, Guowen Liu, Xiaobing Li, Zhe Wang
Gastrointestinal nematodes (GIN) are a crucial restraint to grazing sheep production worldwide. This study was conducted to determine the infections and anthelmintic resistance (AR) of GIN in pasture-based sheep in the Eastern Inner Mongolia, China. GIN eggs were tested from 600 grazing sheep feces of 10 farms using saturated saline flotation method and McMaster's method. The egg hatch test (EHT) and the faecal egg count reduction test (FECRT) were used to evaluate resistance of GIN to anthelmintics. We found that the average infection rate was 79...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/29034424/interaction-mechanisms-between-polycyclic-aromatic-hydrocarbons-pahs-and-organic-soil-washing-agents
#5
Sarah Greish, Åsmund Rinnan, Helle Marcussen, Peter E Holm, Jan H Christensen
Understanding interaction mechanisms between polycyclic aromatic hydrocarbons (PAHs) and soil-washing agents can help in choosing efficient agents which are able to desorb and solubilize PAHs. This study investigated interaction mechanisms between pyrene and four washing agents including: two dissolved organic matters (DOM) F-DOM and CRC-DOM, and two commercial bio-based surfactants BBE-1000 and Supersolv using fluorescence spectroscopy combined with multivariate curve resolution alternating regression (MCR-AR)...
October 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29033804/second-language-word-learning-through-repetition-and-imitation-functional-networks-as-a-function-of-learning-phase-and-language-distance
#6
Ladan Ghazi-Saidi, Ana Ines Ansaldo
Introduction and Aim: Repetition and imitation are among the oldest second language (L2) teaching approaches and are frequently used in the context of L2 learning and language therapy, despite some heavy criticism. Current neuroimaging techniques allow the neural mechanisms underlying repetition and imitation to be examined. This fMRI study examines the influence of verbal repetition and imitation on network configuration. Integration changes within and between the cognitive control and language networks were studied, in a pair of linguistically close languages (Spanish and French), and compared to our previous work on a distant language pair (Ghazi-Saidi et al...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29033586/targeting-the-androgen-receptor-in-triple-negative-breast-cancer-current-perspectives
#7
REVIEW
Alain Mina, Rachel Yoder, Priyanka Sharma
Triple-negative breast cancer (TNBC) is an aggressive subtype associated with frequent recurrence and metastasis. Unlike hormone receptor-positive subtypes, treatment of TNBC is currently limited by the lack of clinically available targeted therapies. Androgen signaling is necessary for normal breast development, and its dysregulation has been implicated in breast tumorigenesis. In recent years, gene expression studies have identified a subset of TNBC that is enriched for androgen receptor (AR) signaling. Interference with androgen signaling in TNBC is promising, and AR-inhibiting drugs have shown antitumorigenic activity in preclinical and proof of concept clinical studies...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29033449/symptomatology-patterns-in-children-with-allergic-rhinitis
#8
Michael Katotomichelakis, Theodoros Iliou, Ioannis Karvelis, Evangelos Giotakis, Gerasimos Daniilides, Eleni Erkotidou, Christos Lazaridis, George K Anastassopoulos
BACKGROUND Although allergic rhinitis (AR) is recognized as a growing global health disease with considerable importance for patients' lives, especially among children and adolescents, there is a lack of population studies concerning symptomatology patterns of the disease. The present study aimed to explore symptoms prevalence among school-aged children, to detect any correlation between allergen sensitivities with symptomatology patterns, and, finally, to evaluate the association of the sensitivity grade score with symptoms severity or seasonality...
October 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29032717/bet-inhibitors-in-metastatic-prostate-cancer-therapeutic-implications-and-rational-drug-combinations
#9
Mark C Markowski, Angelo M De Marzo, Emmanuel S Antonarakis
The bromodomain and extra-terminal (BET) family of proteins are epigenetic readers of acetylated histones regulating a vast network of protein expression across many different cancers. Therapeutic targeting of BET is an attractive area of clinical development for metastatic castration-resistant prostate cancer (mCRPC), particularly due to its putative effect on c-MYC expression and its interaction with the androgen receptor (AR). Areas Covered: We speculate that a combination approach using BET inhibition with other targeted therapies may be required to improve the therapeutic index of BET inhibition in the management of prostate cancer...
October 16, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29032008/3-iodothyroacetic-acid-ta1-a-by-product-of-thyroid-hormone-metabolism-reduces-the-hypnotic-effect-of-ethanol-without-interacting-at-gaba-a-receptors
#10
Annunziatina Laurino, Elisa Landucci, Francesco Resta, Gaetano De Siena, Rosanna Matucci, Alessio Masi, Laura Raimondi
3-iodothyroacetic acid (TA1) is among the by-products of thyroid hormone metabolism suspected to mediate the non-genomic effects of the hormone (T3). We aim to investigate whether TA1 systemically administered to mice stimulated mice wakefulness, an effect already described for T3 and for another T3 metabolite (i.e. 3-iodothryonamine; T1AM), and whether TA1 interacted at GABA-A receptors (GABA-AR). Mice were pre-treated with either saline (vehicle) or TA1 (1.32, 4 and 11 μg/kg) and, after 10 min, they received ethanol (3...
October 11, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29031444/in-situ-synthesis-of-tio2-rutile-anatase-heterostructure-by-dc-magnetron-sputtering-at-room-temperature-and-thickness-effect-of-outermost-rutile-layer-on-photocatalysis
#11
Wang Hui, Shi Guodong, Zhang Xiaoshu, Zhang Wei, Huang Lin, Yu Ying
TiO2 rutile/anatase heterostructure thin films with varying rutile thickness have been in-situ synthesized via DC magnetron sputtering with Ar gas at room temperature. The crystal texture, surface morphology, energy gap and optical properties of the films have been investigated by X-ray diffraction meter, grazing incidence X-ray diffraction meter, Raman spectroscopy, scanning electron microscopy, and UV-visible spectrophotometer, which indicates that the rutile/anatase heterostructure films are successfully fabricated...
October 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29030886/genetics-of-acute-rejection-after-kidney-transplantation
#12
REVIEW
Casey R Dorr, William S Oetting, Pamala A Jacobson, Ajay K Israni
Treatment of acute rejection (AR) following kidney transplantation has improved in recent years, but there are still limitations to successful outcomes. This review article covers literature in regards to recipient and donor genetics of AR kidney and secondarily of liver allografts. Many candidate gene and some genome wide association studies (GWAS) have been conducted for AR in kidney transplantation. Genetic associations with AR in kidney and liver are mostly weak and in most cases the associations have not been reproducible...
October 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29030639/androgen-receptor-increases-hematogenous-metastasis-yet-decreases-lymphatic-metastasis-of-renal-cell-carcinoma
#13
Qingbo Huang, Yin Sun, Xin Ma, Yu Gao, Xintao Li, Yuanjie Niu, Xu Zhang, Chawnshang Chang
Clear cell renal cell carcinoma (ccRCC) is a gender-biased tumor. Here we report that there is also a gender difference between pulmonary metastasis and lymph node metastasis showing that the androgen receptor (AR)-positive ccRCC may prefer to metastasize to lung rather than to lymph nodes. A higher AR expression increases ccRCC hematogenous metastasis yet decreases ccRCC lymphatic metastases. Mechanism dissection indicates that AR enhances miR-185-5p expression via binding to the androgen response elements located on the promoter of miR-185-5p, which suppresses VEGF-C expression via binding to its 3' UTR...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29030564/dynamic-annealing-in-ge-studied-by-pulsed-ion-beams
#14
J B Wallace, L B Bayu Aji, L Shao, S O Kucheyev
The formation of radiation damage in Ge above room temperature is dominated by complex dynamic annealing processes, involving migration and interaction of ballistically-generated point defects. Here, we study the dynamics of radiation defects in Ge in the temperature range of 100-160 °C under pulsed beam irradiation with 500 keV Ar ions when the total ion fluence is split into a train of equal square pulses. By varying the passive portion of the beam duty cycle, we measure a characteristic time constant of dynamic annealing, which rapidly decreases from ~8 to 0...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030409/clinical-relevance-of-androgen-receptor-alterations-in-prostate-cancer
#15
REVIEW
Emma Jernberg, Anders Bergh, Pernilla Wikström
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite continuously improved treatment strategies. Patients with metastatic disease are treated by androgen deprivation therapy (ADT) that with time results in the development of castration-resistant prostate cancer (CRPC) usually established as metastases within bone tissue. The androgen receptor (AR) transcription factor is the main driver of CRPC development and of acquired resistance to drugs given for treatment of CRPC, while a minority of patients have CRPC that is non-AR driven...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29030338/estrogen-replacement-attenuates-stress-induced-pressor-responses-through-vasorelaxation-via-%C3%AE-2-adrenoceptor-in-peripheral-arteries-of-ovariectomized-rats
#16
Shoko Tazumi, Sayo Omoto, Yu Nagatomo, Mariko Kawahara, Naoko Yokota, Mizuho Kawakami, Akira Takamata, Keiko Morimoto
We examined whether chronic estrogen replacement has an inhibitory effect on stress-induced pressor responses via activation of β2-adrenoceptor (AR) in peripheral arteries of ovariectomized rats. Female Wistar rats aged 9 weeks were ovariectomized. After 4 weeks, pellets containing either 17β-estradiol (E2) or placebo (Pla) were subcutaneously implanted into the rats. After 4 weeks of treatment, the rats underwent cage-switch stress and, in a separate experiment, a subset received an infusion of isoproterenol (ISO), with or without pretreatment with β1-AR blocker, atenolol or β2-AR blocker, butoxamine...
October 13, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29029868/does-severe-osteoarthritis-in-knees-with-varus-deformity-alter-the-adductor-ratio
#17
Hakan Boya, S Şükrü Araç
OBJECTIVE: In our retrospective study, we aimed to investigate the differences between the adductor ratio (AR) in knees with and without osteoarthritis, and its validity in determining the articular level. METHODS: Data from 80 knees of 80 patients were retrospectively evaluated. Anteroposterior weight-bearing knee radiographs of the patients with and without osteoarthritis (40 knees in each group) were obtained. The adductor ratio was determined using the following formula: ATJL/FW (adductor tubercle-joint line distance/femoral width)...
October 10, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29029836/uranium-in-agricultural-soils-and-drinking-water-wells-on-the-swiss-plateau
#18
Moritz Bigalke, Lorenz Schwab, Agnes Rehmus, Patrick Tondo, Markus Flisch
Mineral phosphorus fertilizers are regularly applied to agricultural sites, but their uranium (U) content is potentially hazardous to humans and the environment. Fertilizer-derived U can accumulate in the soil, but might also leach to ground-, spring and surface waters. We sampled 19 mineral fertilizers from the canton of Bern and soils of three arable and one forest reference sites at each of four locations with elevated U concentrations (7-28 μg L(-1)) in nearby drinking water wells. The total U concentrations of the fertilizers were measured...
October 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29029785/a-single-dose-of-cocaine-potentiates-glutamatergic-synaptic-transmission-onto-locus-coeruleus-neurons
#19
Feipeng Zhu, Qihui Wu, Jie Li, Katarzyna Grycel, Bing Liu, Xiaoxuan Sun, Li Zhou, Ruiyin Jiao, Rui Song, Younus M Khan, Qinglong Wang, Lun Wang, Yongxin Xu, Jin Li, Bo Zhang, Zhuan Zhou
The brainstem locus coeruleus (LC), the primary norepinephrinergic (NE) nucleus in the brain, has been implicated in the abuse of drugs such as opioids. However, whether and how the LC-NE system is involved in cocaine addiction remains elusive. Here, we demonstrated cocaine-evoked synaptic plasticity of glutamatergic transmission onto LC neurons as one of the earliest traces occurring after a single injection of cocaine. Twenty-four hours after mice were injected intraperitoneally with cocaine, the evoked α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) mediated synaptic transmission onto LC neurons were strongly potentiated without major effect on N-methyl-d-aspartate receptor (NMDAR) mediated synaptic transmission...
November 2017: Cell Calcium
https://www.readbyqxmd.com/read/29029006/large-scale-assessment-of-aortic-stenosis-facing-the-next-cardiac-epidemic
#20
Javier Ramos, Juan Manuel Monteagudo, Teresa González-Alujas, María Eugenia Fuentes, Marta Sitges, María Luisa Peña, Fernando Carrasco-Chinchilla, Tomás Echeverría, Alberto Bouzas, José Francisco Forteza Alberti, Dolores Mesa, Jesús María De La Hera, José Luis Zamorano
Aims: Aortic stenosis (AS) is the most frequent valvular disease in developed countries. As society grows older, the prevalence of AS increases. However, the real burden, current aetiology, severity distribution, and echocardiographic patterns of AS are not fully clear. The aim of the present study is to provide an accurate overall picture of AS, focusing on its epidemiology, aetiology, and echocardiographic features. Methods and results: A total of 29 502 consecutive echocardiograpies were prospectively included in this multicentre study...
September 28, 2017: European Heart Journal Cardiovascular Imaging
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