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https://www.readbyqxmd.com/read/29475090/elevated-intragraft-expression-of-innate-immunity-and-cell-death-related-markers-is-a-risk-factor-for-adverse-graft-outcome
#1
Jianxin Yang, Malou L H Snijders, Geert W Haasnoot, Cees van Kooten, Marko Mallat, Johan W de Fijter, Marian C Clahsen-van Groningen, Frans H J Claas, Michael Eikmans
BACKGROUND: Molecules of the innate immune response are increasingly recognized as important mediators in allograft injury during and after kidney transplantation. We therefore aimed to establish the relationship between the expression of these genes at implantation, during an acute rejection (AR) and on graft outcome. METHODS: A total of 19 genes, including Toll like receptors (TLRs), complement components and regulators, and apoptosis-related genes were analyzed at the mRNA level by qPCR in 123 biopsies with acute rejection and paired pre-transplantation tissue (n = 75)...
February 20, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29474983/an-in-depth-evaluation-of-the-validity-and-logistics-surrounding-the-testing-of-ar-v7-mrna-expression-in-circulating-tumor-cells
#2
Anieta M Sieuwerts, Bianca Mostert, Michelle van der Vlugt-Daane, Jaco Kraan, Corine Beaufort, Mai Van, Wendy J C Prager, Bram De Laere, Nick Beije, Paul Hamberg, Hans M Westgeest, Metin Tascilar, Luc Y Dirix, Wendy Onstenk, Ronald de Wit, Martijn P Lolkema, Ron H J Mathijssen, John W M Martens, Stefan Sleijfer
Recent reports have emphasized the clinical relevance of detecting the androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTCs). Our aim was to set up a validated multicenter pipeline to measure AR-V7 by RT-qPCR in RNA isolated from CellSearch-enriched CTCs to provide an AR-V7 positive/negative score in a clinically acceptable time range. CellSearch-enirched CTCs from metastatic castration-resistant prostate cancer patients were characterized by RT-qPCR. After optimization it was prospectively tested whether it was possible to report the AR-V7 status within 11 days (PRELUDE study)...
February 20, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29473182/the-androgen-receptor-malignancy-shift-in-prostate-cancer
#3
REVIEW
Ben T Copeland, Sumanta K Pal, Eric C Bolton, Jeremy O Jones
BACKGROUND: Androgens and the androgen receptor (AR) are necessary for the development, function, and homeostatic growth regulation of the prostate gland. However, once prostate cells are transformed, the AR is necessary for the proliferation and survival of the malignant cells. This change in AR function appears to occur in nearly every prostate cancer. We have termed this the AR malignancy shift. METHODS: In this review, we summarize the current knowledge of the AR malignancy shift, including the DNA-binding patterns that define the shift, the transcriptome changes associated with the shift, the putative drivers of the shift, and its clinical implications...
February 23, 2018: Prostate
https://www.readbyqxmd.com/read/29472733/androgen-interacts-with-exercise-through-the-mtor-pathway-to-induce-skeletal-muscle-hypertrophy
#4
Fanxing Zeng, Hua Zhao, Jingwen Liao
This study was designed to investigate the effects of exogenous androgen and resistance exercise on skeletal muscle hypertrophy and the role of the mammalian target of rapamycin (mTOR) signalling during the process. A total of 24 male Sprague-Dawley rats were randomly assigned to sham operation and dihydrotestosterone (DHT) implantation groups with subgroups subjected to sedentary conditions or resistance exercise (SHAM+SED, SHAM+EX, DHT+SED, and DHT+EX). The experimental procedure lasted for 10 days. The mRNA expression of androgen receptor (AR) and insulin-like growth factor I (IGF-I), the expression of myosin heavy chain (MHC), as well as the phosphorylation statuses of AR, mTOR, p70 ribosomal S6 kinase (p70S6K ), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) were determined in the white gastrocnemius muscle...
December 2017: Biology of Sport
https://www.readbyqxmd.com/read/29472025/aortic-stenosis-and-aortic-regurgitation-express-different-titin-isoforms-differences-and-relationships-with-functional-and-geometric-characteristics
#5
Vito Mannacio, Luigi Mannacio, Anita Antignano, Vincenzo De Amicis, Francesco Musumeci, Gabriele Iannelli
Background-Titin represents an important biomechanical sensor which determines compliance and diastolic/systolic function of the left ventricle (LV). To assess the different titin-isoform expression and the relationships with functional and geometric patterns, we analyzed titin-isoform expression and cardiomyocytes contractile function in myocardial biopsy samples of patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) and for aortic regurgitation (AR). Method -Specimens, collected from the LV of 35 with AS and 35 with AR undergoing AVR were analyzed for titin-isoform expression and cardiomyocytes force measurement...
February 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29471652/formation-and-identification-of-borane-radical-anions-isolated-in-solid-argon
#6
Meng-Yeh Lin, Tzu-Ping Huang, Chih-Hao Chin, Yu-Jong Wu
The infrared (IR) spectrum of borane(3) anions (BH3 - ) isolated in solid Ar was recorded; two vibrational modes were observed at 2259.4 and 606.6 cm-1 , which were assigned to the BH2 stretching (ν3 ) and out-of-plane large-amplitude (ν2 ) modes, respectively. These anions were produced by the electron bombardment of an Ar matrix sample containing a small proportion of B2 H6 and H2 during matrix deposition or by the photolysis of single-bridged-B2 H5 - in an Ar matrix with the selected ultraviolet light...
February 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29471636/semiclassical-analysis-of-jm-%C3%A2-j-m-transitions-in-rotationally-inelastic-collisions-in-cell-experiments
#7
T J Price, A P Hickman
Recent quantum calculations of rotationally inelastic collisions of NaK (A1 Σ+ ) with He or Ar in a cell experiment are analyzed using semiclassical approximations valid for large quantum numbers. The results suggest a physical interpretation of jm → j'm' transitions based on the vector model and lead to expressions that explicitly involve the initial and final polar angles of the angular momentum of the target molecule. The relation between the polar angle θ and the azimuthal quantum number m links the semiclassical results for the change in polar angle (θ → θ') to quantum results for an m → m' transition...
February 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29471620/augmented-reality-for-breast-imaging
#8
Alberto Rancati, Claudio Angrigiani, Maurizio B Nava, Giuseppe Catanuto, Nicola Rocco, Fernando Ventrice, Julio Dorr
BACKGROUND: Augmented reality (AR) enables the superimposition of virtual reality reconstructions onto clinical images of a real patient, in real time. This allows visualization of internal structures through overlying tissues, thereby providing a virtual transparency vision of surgical anatomy. AR has been applied to neurosurgery, which utilizes a relatively fixed space, frames, and bony references; the application of AR facilitates the relationship between virtual and real data. Augmented Breast imaging (ABI) is described...
February 21, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29471436/antiandrogen-treatment-ameliorates-reproductive-and-metabolic-phenotypes-in-the-letrozole-induced-mouse-model-of-pcos
#9
Genevieve E Ryan, Shaddy Malik, Pamela L Mellon
Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women of reproductive age, is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Although its etiology is unknown, excess androgens are thought to be a critical factor driving the pathology of PCOS. We previously demonstrated that continuous exposure to the aromatase inhibitor letrozole (LET) in mice produces many hallmarks of PCOS, including elevated testosterone (T) and luteinizing hormone (LH), anovulation, and obesity...
February 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29471302/socs3-is-upregulated-and-targeted-by-mir30a-5p-in-allergic-rhinitis
#10
Chun Yuan Zhao, Wei Wang, Hong Chao Yao, Xin Wang
BACKGROUND: Suppressor of cytokine signaling 1 (SOCS1) and SOCS3 play important roles in T helper cell differentiation, which is involved with the pathologic mechanisms of allergic rhinitis (AR). The aim of this study was to evaluate the expression of SOCS1 and SOCS3 in AR and find their regulatory microRNAs (miRNAs) to provide a basis for the treatment of AR. METHODS: The expression of SOCS1 and SOCS3 were analyzed by real-time PCR, immunohistochemistry, and Western blot...
February 22, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29470537/microsomal-prostaglandin-e-synthase-1-gene-deletion-impairs-neuro-immune-circuitry-of-the-cholinergic-anti-inflammatory-pathway-in-endotoxaemic-mouse-spleen
#11
Priya Revathikumar, Johanna Estelius, Utsa Karmakar, Erwan Le Maître, Marina Korotkova, Per-Johan Jakobsson, Jon Lampa
The cholinergic anti-inflammatory pathway (CAP) is an innate neural reflex where parasympathetic and sympathetic nerves work jointly to control inflammation. Activation of CAP by vagus nerve stimulation (VNS) has paved way for novel therapeutic strategies in treating inflammatory diseases. Recently, we discovered that VNS mediated splenic acetylcholine (ACh) release and subsequent immunosuppression in response to LPS associated inflammation is impaired in mice lacking microsomal prostaglandin E synthase-1 (mPGES-1) expression, a key enzyme responsible for prostaglandin E2 synthesis...
2018: PloS One
https://www.readbyqxmd.com/read/29470134/the-effect-of-aronia-berry-on-type-1-diabetes-in-vivo-and-in-vitro
#12
Yong-Deok Jeon, Sa-Haeng Kang, Kwang-Hyun Moon, Jeong-Ho Lee, Dae-Geun Kim, Wook Kim, Jong-Sung Kim, Byung-Yong Ahn, Jong-Sik Jin
The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two types according to the etiopathogenic mechanism and insulin dependence. Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia. Aronia berry has been used as a medicinal food in Europe...
February 22, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29468829/disease-progression-and-variation-in-clinical-practice-for-isolated-bicuspid-aortic-valve-in-children
#13
Melissa S W Yamauchi, Michael D Puchalski, Hsin Ti Weng, Nelangi M Pinto, Susan P Etheridge, Angela P Presson, Lloyd Y Tani, L LuAnn Minich, Richard V Williams
BACKGROUND: Disease progression of an isolated bicuspid aortic valve (BAV) in children is poorly understood and adult management guidelines may not be applicable. Thus, we sought to evaluate disease progression of pediatric isolated BAV and its relationship to current management practices. METHODS: Children with a BAV and ≤mild aortic stenosis (AS) and/or aortic regurgitation (AR) at the time of initial evaluation were included in this retrospective cohort study (1/2005-12/2014)...
February 21, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29468811/robotic-rectal-surgery-in-korea-analysis-of-a-nationwide-registry
#14
Se-Jin Baek, Jung-Myun Kwak, Jin Kim, Seon-Hahn Kim, Sungsoo Park
BACKGROUND: The aim of this study is to analyze the progress and the present state of application of robotic rectal surgery in Korea. METHODS: We used data from patients who underwent robotic, laparoscopic or open approaches for four types of operative procedures between 2006 and 2014: (1) anterior resection (AR), (2) low anterior resection (LAR), (3) intersphincteric resection (ISR) and (4) abdominoperineal resection (APR). RESULTS: The number of hospitals performing robotic rectal surgery has increased...
February 22, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29468239/living-ring-opening-polymerization-of-%C3%AE%C2%B5-caprolactone-catalyzed-by-%C3%AE-quinolyl-enamino-aluminium-complexes-ligand-electronic-effects
#15
Peng Wang, Jianbin Chao, Xia Chen
A series of β-quinolyl-enamino aluminium complexes [AlLMe2 ] 1-7 {L = [(2-C9 H6 N)-CH[double bond, length as m-dash]C(4-MeC6 H4 )-N(Ar)-], Ar = C6 H5 (1), 4-FC6 H4 (2), 3,4,5-F3 C6 H2 (3), C6 F5 (4), 5-t BuC6 H4 (5), 2,6-Me2 C6 H3 (6), and 2,6-i Pr2 C6 H3 (7)} were synthesized by the reaction of AlMe3 with the corresponding β-quinolyl-enamine ligands. All the complexes were characterized by1 H and13 C NMR spectroscopy and elemental analysis. The molecular structures of complexes 1-3 and 7 were confirmed by single-crystal X-ray diffraction, which revealed that all the Al atoms adopt a distorted tetrahedral geometry...
February 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29467668/identification-and-functional-analysis-of-the-first-aquaporin-from-striped-stem-borer-chilo-suppressalis
#16
Ming-Xing Lu, Dan-Dan Pan, Jing Xu, Yang Liu, Gui-Rong Wang, Yu-Zhou Du
Aquaporins are integral membrane proteins some of which form high capacity water-selective channels, promoting water permeation across cell membranes. In this study, we isolated the aquaporin transcript ( Cs Drip1) of Chilo suppressalis , one of the important rice pests. Cs Drip1 included two variants, Cs Drip1_v1 and Cs Drip1_v2. Although Cs Drip1_v2 sequence (>409 bp) was longer than Cs Drip1_v1, they possessed the same open reading frame (ORF). Protein structure and topology of Cs Drip1 was analyzed using a predicted model, and the results demonstrated the conserved properties of insect water-specific aquaporins, including 6 transmembrane domains, 2 NPA motifs, ar/R constriction region (Phe69 , His194 , Ser203 , and Arg209 ) and the C-terminal peptide sequence ending in "SYDF...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29466694/lipid-pathway-deregulation-in-advanced-prostate-cancer
#17
REVIEW
Laura Galbraith, Hing Y Leung, Imran Ahmad
The link between prostate cancer (PC) development and lipid metabolism is well established, with AR intimately involved in a number of lipogenic processes involving SREBP1, PPARG, FASN, ACC, ACLY and SCD1. Recently, there is growing evidence implicating the role of obesity and peri-prostatic adipose tissue (PPAT) in PC aggressiveness and related mortality, suggesting the importance of lipid pathways in both localised and disseminated disease. A number of promising agents are in development to target the lipogenic axis in PC, and the likelihood is that these agents will form part of combination drug strategies, with targeting of multiple metabolic pathways (e...
February 18, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29466489/moderate-continuous-aerobic-exercise-training-improves-cardiomyocyte-contractility-in-%C3%AE-1-adrenergic-receptor-knockout-mice
#18
Aurora Corrêa Rodrigues, Antônio José Natali, Daise Nunes Queiroz da Cunha, Alexandre Jayme Lopes Dantas Costa, Anselmo Gomes de Moura, Miguel Araújo Carneiro-Júnior, Leonardo Bonato Félix, Patrícia Chakur Brum, Thales Nicolau Prímola-Gomes
BACKGROUND: The lack of cardiac β1-adrenergic receptors (β1-AR) negatively affects the regulation of both cardiac inotropy and lusitropy, leading, in the long term, to heart failure (HF). Moderate-intensity aerobic exercise (MCAE) is recommended as an adjunctive therapy for patients with HF. OBJECTIVE: We tested the effects of MCAE on the contractile properties of left ventricular (LV) myocytes from β1 adrenergic receptor knockout (β1ARKO) mice. METHODS: Four- to five-month-old male wild type (WT) and β1ARKO mice were divided into groups: WT control (WTc) and trained (WTt); and β1ARKO control (β1ARKOc) and trained (β1ARKOt)...
February 19, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29465816/classical-n-heterocyclic-carbenes-derived-crystalline-radicals
#19
Rajendra Ghadwal, Dennis Rottschäfer, Beate Neumann, Hans-Georg Stammler, Maurice van Gastel, Diego Andrada
One electron reduction of C2-arylated 1,3-imidazoli(ni)um salts (IPrAr)Br (Ar = Ph, 3a; 4-DMP, 3b; 4-DMP = 4-Me2NC6H4) and (SIPrAr)I (Ar = Ph, 4a; 4-Tol, 4b) derived from classical NHCs (IPr = :C{N(2,6-iPr2C6H3)}2CHCH, 1; SIPr = :C{N(2,6- iPr2C6H3)}2CH2CH2, 2) gives radicals [(IPrAr)]* (Ar = Ph, 5a; 4-DMP, 5b) and [(SIPrAr)]* (Ar = Ph, 6a; 4-Tol, 6b). Each of 5a,b and 6a,b exhibits a doublet EPR signal, a characteristic of monoradical species. The first solid-state characterization of NHC-derived carbon-centered radicals 6a,b by single crystal X-ray diffraction is reported...
February 21, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29464943/molecular-profiling-of-pooled-circulating-tumor-cells-from-prostate-cancer-patients-using-dual-antibody-functionalized-microfluidic-device
#20
Changqing Yin, Yuhui Wang, Jia Ji, Bo Cai, Hao Chen, Zhonghua Yang, Kun Wang, Changliang Luo, Wu-Wen Zhang, Chunhui Yuan, Fubing Wang
Here, we constructed a novel dual-antibody-functionalized microfluidic device by employing antibodies against PSMA and EpCAM to capture CTCs from PCa patients in order to capture multiple subpopulations of CTCs at different metastatic stages. In vitro experiments with dual capture system for capturing both LnCAP and LnCAP-EMT cells have shown significantly enhanced capture efficiency as compared to that of EpCAM single capture system. Furthermore, dual capture system could successfully identify CTCs in 20 out of 24 (83...
February 21, 2018: Analytical Chemistry
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