keyword
https://read.qxmd.com/read/38413296/risk-factors-for-mortality-in-children-with-hemorrhagic-cystitis-after-hematopoietic-transplant
#21
JOURNAL ARTICLE
Daniel Salevitz, Lucia Mirea, Gwen M Grimsby
INTRODUCTION: Hemorrhagic cystitis (HC) is a devastating complication of bone marrow (BMT) and stem cell transplant (SCT). Much of the literature has focused on exclusively adult patient populations, with limited evidence regarding risk factors for mortality and morbidity among pediatric HC patients. OBJECTIVE: To examine factors associated with all-cause mortality in children with HC after BMT/SCT. METHODS: The Pediatric Health Information System database was queried for patients with ICD-9/10 codes for hematopoietic transplant and gross hematuria, hematuria unspecified, or cystitis with hematuria...
February 15, 2024: Journal of Pediatric Urology
https://read.qxmd.com/read/38396090/association-of-continuous-kidney-replacement-therapy-timing-and-mortality-in-critically-ill-children
#22
JOURNAL ARTICLE
Maureen A Banigan, Garrett Keim, Danielle Traynor, Nadir Yehya, Robert B Lindell, Julie C Fitzgerald
BACKGROUND: Acute kidney injury (AKI) is a common complication of critical illness and associated with high morbidity and mortality. Optimal timing of continuous kidney replacement therapy (CKRT) in children is unknown. We aimed to measure the association between timing of initiation and mortality. METHODS: This is a single-center retrospective cohort study of pediatric patients receiving CKRT from 2013 to 2019. The primary exposure, time to CKRT initiation, was measured from onset of stage 3 AKI during hospitalization (defined using Kidney Disease: Improving Global Outcomes creatinine and urine output criteria) and analyzed as both a continuous and categorical variable...
February 23, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38393726/major-adverse-kidney-events-in-pediatric-continuous-kidney-replacement-therapy
#23
JOURNAL ARTICLE
Dana Y Fuhrman, Erin K Stenson, Issa Alhamoud, Rashid Alobaidi, Gabriella Bottari, Sarah Fernandez, Francesco Guzzi, Taiki Haga, Ahmad Kaddourah, Eleonora Marinari, Tahagod H Mohamed, Catherine J Morgan, Theresa Mottes, Tara M Neumayr, Nicholas J Ollberding, Valeria Raggi, Zaccaria Ricci, Emily See, Natalja L Stanski, Huaiyu Zang, Emily Zangla, Katja M Gist
IMPORTANCE: Continuous kidney replacement therapy (CKRT) is increasingly used in youths with critical illness, but little is known about longer-term outcomes, such as persistent kidney dysfunction, continued need for dialysis, or death. OBJECTIVE: To characterize the incidence and risk factors, including liberation patterns, associated with major adverse kidney events 90 days after CKRT initiation (MAKE-90) in children, adolescents, and young adults. DESIGN, SETTING, AND PARTICIPANTS: This international, multicenter cohort study was conducted among patients aged 0 to 25 years from The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) registry treated with CKRT for acute kidney injury or fluid overload from 2015 to 2021...
February 5, 2024: JAMA Network Open
https://read.qxmd.com/read/38374576/racial-and-ethnic-composition-of-populations-served-by-free-standing-children-s-hospitals-and-disparities-in-outcomes-of-pediatric-lupus
#24
JOURNAL ARTICLE
Joyce C Chang, Jessica P Liu, Laura M Berbert, Mia T Chandler, Pooja N Patel, Emily A Smitherman, Edie A Weller, Mary Beth F Son, Karen H Costenbader
OBJECTIVE: Health disparities may be driven by hospital-level factors. We assessed whether racial and ethnic composition of populations hospitals serve explain or modify disparities in hospital outcomes of children with systemic lupus erythematosus (SLE). METHODS: In this retrospective cohort study of patients 5-26 years old with SLE at 47 children's hospitals in the Pediatric Health Information System (2006-2021), race and ethnicity were assessed at the patient-level and hospital-level (proportion of total admissions comprised by Black or Hispanic patients, respectively)...
February 19, 2024: Arthritis Care & Research
https://read.qxmd.com/read/38364956/continuous-kidney-replacement-therapy-and-survival-in-children-and-young-adults-findings-from-the-multi-national-we-rock-collaborative
#25
JOURNAL ARTICLE
Michelle C Starr, Katja M Gist, Huaiyu Zang, Nicholas J Ollberding, Shanthi Balani, Andrea Cappoli, Eileen Ciccia, Catherine Joseph, Aadil Kakajiwala, Aaron Kessel, Melissa Muff-Luett, María J Santiago Lozano, Matthew Pinto, Stephanie Reynaud, Sonia Solomon, Cara Slagle, Rachana Srivastava, Weiwen V Shih, Tennille Webb, Shina Menon
RATIONALE & OBJECTIVE: There are limited studies describing the epidemiology and outcomes of children and young adults receiving continuous kidney replacement therapy (CKRT). We aimed to describe associations between patient characteristics, CKRT prescription, and survival. STUDY DESIGN: Retrospective multicenter cohort study. SETTING: & Participants: 980 patients aged birth-25 years old who received CKRT between 2015 and 2021 at 1 of 32 centers in 7 countries participating in the Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Diseases (WE-ROCK)...
February 14, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38347283/hemodiafiltration-for-children-with-stage-5-chronic-kidney-disease-technical-aspects-and-outcomes
#26
JOURNAL ARTICLE
Charlotte Ahlmann, Lynsey Stronach, Kathryn Waters, Kate Walker, Jun Oh, Claus Peter Schmitt, Bruno Ranchin, Rukshana Shroff
Despite significant medical and technical improvements in the field of dialysis, the morbidity and mortality among patients with chronic kidney disease (CKD) stage 5 on dialysis remains extremely high. Hemodiafiltration (HDF), a dialysis method that combines the two main principles of hemodialysis (HD) and hemofiltration-diffusion and convection-has had a positive impact on survival when delivered with a high convective dose. Improved outcomes with HDF have been attributed to the following factors: HDF removes middle molecular weight uremic toxins including inflammatory cytokines, increases hemodynamic stability, and reduces inflammation and oxidative stress compared to conventional HD...
February 13, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38347282/the-effect-of-gastrostomy-tube-feeding-on-growth-in-children-with-chronic-kidney-disease-and-on-dialysis
#27
JOURNAL ARTICLE
Abdulelah Alshaiban, Adebola Osuntoki, Shelley Cleghorn, Antonia Loizou, Rukshana Shroff
BACKGROUND: Gastrostomy tube (GT) feeding is used to promote nutrition and growth in children with chronic kidney disease (CKD). We explored the relationship between gastrostomy feeding and growth parameters in children with CKD, looking specifically at the nutritional composition of feeds. METHODS: Children with CKD stages 3-5 or on dialysis in a tertiary children's kidney unit were studied. Data on anthropometry, biochemistry, and nutritional composition of feeds were collected from the time of GT insertion for 3 years or until transplantation...
February 13, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38344624/a-systematic-review-of-pediatric-dialysis-in-asia-unveiling-demographic-trends-clinical-representation-and-outcomes
#28
REVIEW
Tanzir I Britto, Mohammad E Hoque, Shaikh A Fattah
Dialysis in pediatric groups is complicated by a wide range of factors that can affect long-term prognosis. The purpose of this meta-analysis and systematic review is to better understand the demographic and clinical factors that affect dialysis success in children. We searched a variety of databases for relevant articles and included 14 reports that dealt with the case studies of pediatric patients undergoing dialysis for a wide range of renal diseases. Patients' demographics, clinical presentations, laboratory findings, and treatment outcomes were the primary areas of data collection...
January 2024: Curēus
https://read.qxmd.com/read/38341276/management-of-adult-patients-with-podocytopathies-an-update-from-the-era-immunonephrology-working-group
#29
JOURNAL ARTICLE
Safak Mirioglu, Lisa Daniel-Fischer, Ilay Berke, Syed Hasan Ahmad, Ingeborg M Bajema, Annette Bruchfeld, Gema M Fernandez-Juarez, Jürgen Floege, Eleni Frangou, Dimitrios Goumenos, Megan Griffith, Sarah M Moran, Cees van Kooten, Stefanie Steiger, Kate I Stevens, Kultigin Turkmen, Lisa C Willcocks, Andreas Kronbichler
The histopathological lesions, minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), are entities without immune complex deposits which can cause podocyte injury, thus frequently grouped under the umbrella of podocytopathies. Whether MCD and FSGS may represent a spectrum of the same disease remains a matter of conjecture. Both frequently require repeated high-dose glucocorticoid therapy with alternative immunosuppressive treatments reserved for relapsing or resistant cases and response rates are variable...
February 10, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38336457/national-study-on-the-risks-of-covid-19-infection-for-paediatric-kidney-transplant-recipients-a-retrospective-cross-sectional-study
#30
JOURNAL ARTICLE
Charlotte Withers, Rishil Patel, Ben C Reynolds, Martin Christian, Mordi Muorah, Yincent Tse, Liz Edwards, Pallavi Yadav, Shuman Haq, Shivaram Hegde, Chris J Callaghan, Alasdair Bamford, Stephen D Marks
INTRODUCTION: During the COVID-19 pandemic, evidence emerged that immunosuppressed children were less affected by COVID-19 infections compared with immunosuppressed adults. The aim of our study was to investigate how COVID-19 infections affected paediatric kidney transplant recipients (pKTR) in the UK. METHODS: Questionnaires regarding COVID-19 infection data and care of pKTR during the COVID-19 pandemic were sent to all 13 UK paediatric nephrology centres examining asymptomatic and symptomatic pKTR with positive COVID-19 PCR testing from 1 April 2020 to 1 December 2021...
February 9, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38334438/outcomes-of-prophylactic-peritoneal-dialysis-catheter-insertion-in-children-undergoing-cardiac-surgery-a-systematic-review-and-meta-analysis
#31
JOURNAL ARTICLE
Emma H Ulrich, Prabhjot K Bedi, Rashid Alobaidi, Catherine J Morgan, Mike Paulden, Michael Zappitelli, Sean M Bagshaw
OBJECTIVES: The objective of this Prospective Register of Systematic Reviews (CRD42022384192) registered systematic review and meta-analysis was to determine whether prophylactic peritoneal dialysis (PD) catheter insertion at the time of pediatric cardiac surgery is associated with improved short-term outcomes. DATA SOURCES: Databases search of the MEDLINE, EMBASE, CINAHL, and Cochrane Library completed in April 2021 and updated October 2023. STUDY SELECTION: Two reviewers independently completed study selection, data extraction, and bias assessment...
February 9, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38327222/pediatric-kidney-care-experience-after-the-2023-turkey-syria-earthquake
#32
JOURNAL ARTICLE
Sevcan A Bakkaloğlu, Ali Delibaş, Serra Sürmeli Döven, Sevgin Taner, Sevgi Yavuz, Gökçen Erfidan, Esra Danacı Vatansever, Fatma Aynacı, Kenan Yilmaz, Mehmet Taşdemir, Okan Akacı, Nurver Akıncı, Serçin Güven, Neslihan Çiçek, Ismail Dursun, Emre Keleşoğlu, Muhammet Sancaktar, Demet Alaygut, Seha Saygılı, Önder Yavaşcan, Alev Yılmaz, Kaan Gülleroğlu, Pelin Ertan, Belde Kasap Demir, Hakan Poyrazoğlu, Seda Pınarbaşı, Aylin Gençler, Funda Baştuğ, Neslihan Günay, Kübra Çeleğen, Aytül Noyan, Gönül Parmaksız, Begüm Avcı, Fatma Şemsa Çaycı, Umut Bayrakçı, Sare Gülfem Özlü, Özlem Yüksel Aksoy, Sibel Yel, Güldane Aylin İnal, Seçil Köse, Aysun Karabay Bayazıt, Bahriye Atmış, Emel Sarıbaş, Çağla Çağlı, Yılmaz Tabel, Ahmet Taner Elmas, Şenay Zırhlı Selçuk, Beltinge Demircioğlu Kılıç, Mehtap Akbalık Kara, Mithat Büyükçelik, Ayşe Balat, Betül Durucu Tiryaki, Bilge Erdoğdu, Bağdagül Aksu, Günay Mahmudova, Hasan Dursun, Cengiz Candan, Nilüfer Göknar, Fatma Mutlubaş, Seçil Arslansoyu Çamlar, Cemaliye Başaran, Burcu Bulum Akbulut, Ali Düzova, Bora Gülhan, Çiğdem Oruç, Harun Peru, Harika Alpay, Özde Nisa Türkkan, Rüveyda Gülmez, Mehtap Çelakıl, Kenan Doğan, Ilmay Bilge, Cemile Pehlivanoğlu, Bahar Büyükkaragöz, Emre Leventoğlu, Nuray Alpman, Cengiz Zeybek, Sebahat Tülpar, Rümeysa Yasemin Çiçek Gülşan, Aslıhan Kara, Metin Kaya Gürgöze, Esra Nagehan Önder Akyol, Yeşim Özdemir Atikel, Serim Pul, Ferah Sönmez, Gizem Yıldız, Sema Akman, Midhat Elmacı, Nuran Küçük, Selçuk Yüksel, Aslı Kavaz, Hülya Nalçacıoğlu, Caner Alparslan, Nida Dinçel, Atilla H Elhan, Lale Sever
BACKGROUND/AIMS: Two earthquakes on February 6th, 2023 destroyed ten cities in Türkiye. We report our experience with pediatric victims during these catastrophes, with a focus on crush syndrome related-acute kidney injury (Crush-AKI) and death. METHOD: A web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, and kidney and overall outcomes were asked. RESULTS: 903 injured children (median age: 11...
February 7, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38320362/heart-transplantation-for-adults-with-congenital-heart-disease-can-be-performed-at-adult-or-pediatric-hospitals-with-comparable-outcomes
#33
JOURNAL ARTICLE
Krishna Bhandari, Khaled Shorbaji, Curry Sherard, Sarah Chen, Brett Welch, Arman Kilic
INTRODUCTION: The goal of this study was to evaluate the relationship between hospital-related factors and hospital type on outcomes of heart transplantation for patients with adult congenital heart disease (ACHD). METHODS: Patients with ACHD who underwent heart transplant between 2010 and 2021 were identified using the United Network for Organ Sharing data registry. The primary outcome was post-transplant mortality. Kaplan-Meier unadjusted survival curves were compared using the log-rank test...
February 5, 2024: Journal of Surgical Research
https://read.qxmd.com/read/38317757/intradialytic-hypotension-and-mortality-in-adolescents-and-young-adults-with-kidney-failure-receiving-maintenance-hemodialysis
#34
JOURNAL ARTICLE
Xixi Zhao, Tara I Chang, Wolfgang C Winkelmayer, Jin Long, Sai Liu, Olivera Marsenic
RATIONALE & OBJECTIVE: Intradialytic hypotension (IDH) is associated with mortality in adults with kidney failure requiring hemodialysis (HD); however, large-scale pediatric studies are lacking. Moreover, there is no evidence-based consensus definition of IDH in pediatric literature. We aimed to examine the association of commonly used definitions of IDH with mortality in adolescents and young adults. STUDY DESIGN: This was a retrospective observational cohort study...
February 2024: Kidney medicine
https://read.qxmd.com/read/38317228/a-retrospective-analysis-of-acute-kidney-injury-in-children-with-post-covid-19-multisystem-inflammatory-syndrome-insights-into-promising-outcomes
#35
JOURNAL ARTICLE
Hanan El-Halaby, Riham Eid, Ahmed Elagamy, Ahmed El-Hussiny, Fatma Moustafa, Ayman Hammad, Mayada Zeid
BACKGROUND: Acute kidney injury (AKI) in patients with multisystem inflammatory syndrome (MIS), COVID-19 related infection has been increasingly recognized with a paucity of data on AKI incidence, related mortality, and the requirement of renal replacement therapy in children with MIS (MIS-C). METHODS: This is a retrospective study evaluating the prevalence, severity, management and outcomes of AKI in a cohort of Egyptian children with MIS-children (MIS-C) post-COVID infection...
February 5, 2024: Italian Journal of Pediatrics
https://read.qxmd.com/read/38303642/survival-of-infants-with-severe-congenital-kidney-disease-after-ecmo-and-kidney-support-therapy
#36
JOURNAL ARTICLE
Kara Short, Martha McBride, Scott Anderson, Rachel Miller, Daryl Ingram, Carl Coghill, Brian Sims, David Askenazi
Congenital kidney failure not only affects the homeostatic functions of the kidney, but also affects neonatal respiratory integrity. Until recently, extracorporeal membrane oxygenation (ECMO) support was not used in this population because the need for ECMO clearly established nonviability. Since 2016, 31 neonates have been admitted to the NICU at Children's of Alabama with congenital kidney failure. Five patients were placed on ECMO for severe respiratory distress unresponsive to conventional interventions...
February 2, 2024: Pediatrics
https://read.qxmd.com/read/38285058/neurodevelopmental-profile-of-infants-and-toddlers-awaiting-a-kidney-transplant
#37
JOURNAL ARTICLE
Danielle Glad, Christopher Anzalone, Finola Kane-Grade, Lidan Gu, Michael Evans, Sarah Kizilbash
BACKGROUND: Infants and toddlers with kidney failure are susceptible to neurodevelopmental delays due to medical comorbidities and rapid brain development in early childhood. However, research on the neuropsychological development of this patient population has been limited over the past 10 years. METHODS: We performed a retrospective study to evaluate the neurodevelopmental functioning of infants/toddlers with kidney failure who completed the Bayley Scales of Infant and Toddler Development (3rd and 4th Edition) as part of a pretransplant evaluation between 2010 and 2022 (n = 23; Mage  = 18 months, SD = 8...
January 29, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38267590/use-of-clearguard-hd-caps-in-pediatric-hemodialysis-patients
#38
JOURNAL ARTICLE
Amy Nau, Troy Richardson, Diana Cardwell, Jennifer Ehrlich, Jyothsna Gattineni, Melisha Hanna, Mahima Keswani, Emily Neibauer, Kelly Nitz, Raymond Quigley, Michelle Rheault, Rebekah Sims, Mayna Woo, Bradley A Warady
BACKGROUND: Bloodstream infections (BSIs) are a leading cause of hospitalizations and mortality among patients receiving hemodialysis (HD) therapy, especially those with a central venous catheter (CVC) for dialysis access. The use of chlorhexidine impregnated catheter caps (ClearGuard) has been associated with a decrease in the rate of HD catheter-related BSIs (CA-BSIs) in adults; similar data have not been published for children. METHODS: We compared CA-BSI data from participating centers within the Standardizing Care to Improve Outcomes in Pediatric Endstage Kidney Disease (SCOPE) collaborative based on the center's use of ClearGuard caps for patients with HD catheter access...
January 25, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38265486/wt1-exon-10-missense-variant-in-a-pediatric-patient-with-focal-segmental-glomerulosclerosis-with-embryonal-hyperplasia
#39
JOURNAL ARTICLE
Mari Kurokawa, Manao Nishimura, Kei Nishiyama, Kentaro Matsuoka, China Nagano, Yoshitsugu Kaku
A 6-year-old boy was diagnosed with chromosomal abnormalities (48,XYY, + 21[11]/46,XY[19]) at 4 months of age after a physical examination revealed an undescended testis and a dwarf penis. He also had mild renal dysfunction and severe proteinuria, and kidney biopsy at 2 years of age revealed focal segmental glomerulosclerosis. Genetic analysis to investigate suspected WT1 gene abnormalities revealed a novel variant in NM_024426.6:exon10:c.1506 T > A (p.(Asp502Glu))...
January 24, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38261064/epidemiology-and-outcomes-of-pediatric-autosomal-recessive-polycystic-kidney-disease-in-the-middle-east-and-north-africa
#40
REVIEW
Mohamed A Salman, Ahmed Elgebaly, Neveen A Soliman
The incidence of rare diseases is expected to be comparatively higher in the Middle East and North Africa (MENA) region than in other parts of the world, attributed to the high prevalence of consanguinity. Most MENA countries share social and economic statuses, cultural relativism, religious beliefs, and healthcare policies. Polycystic kidney diseases (PKDs) are the most common genetic causes of kidney failure, accounting for nearly 8.0% of dialysis cases. The development of PKDs is linked to variants in several genes, including PKD1, PKD2, PKHD1, DZIP1L, and CYS1...
January 23, 2024: Pediatric Nephrology
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