keyword
https://read.qxmd.com/read/38442740/development-and-external-validation-of-a-home-based-risk-prediction-model-of-natural-onset-of-menopause-teuta
#21
JOURNAL ARTICLE
Lum Kastrati, Pedro Marques Vidal, Klodian Dhana, Lia Bally, Irene Lambrinoudaki, Dion Groothof, Stephan J L Bakker, Michele F Eisenga, Taulant Muka
OBJECTIVE: To develop and externally validate a 10-year risk prediction model of natural onset of menopause using ready-to-use predictors. DESIGN: Population-based prospective cohort study. PARTICIPANTS: Community-dwelling, premenopausal women aged 28 years and older enrolled in the Swiss (CoLaus) and Dutch (PREVEND) study. MAIN OUTCOME MEASURE: Incidence of self-reported natural menopause. MODEL DEVELOPMENT: Based on existing literature, 11 predictors were tested in this study...
March 5, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38442312/association-between-neighborhood-poverty-and-ovarian-reserve-the-ovarian-aging-study
#22
JOURNAL ARTICLE
Anwesha Pan, Kyle D Crowder, Marcelle I Cedars, Maria E Bleil
OBJECTIVE: This study aimed to examine the association between neighborhood poverty and ovarian reserve. METHODS: Among 1,019 healthy premenopausal women in the Ovarian Aging Study, aggregate exposure to neighborhood poverty was examined in relation to biomarkers of ovarian reserve, antimüllerian hormone (AMH) and antral follicle count (AFC). Specifically, the interaction of age-x-neighborhood poverty was assessed cross-sectionally to determine whether AMH and AFC declines across women may be greater in women exposed to more neighborhood poverty...
March 5, 2024: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/38442308/body-composition-physical-activity-and-menopause-symptoms-how-do-they-relate
#23
JOURNAL ARTICLE
Sam R Moore, Hannah E Cabre, Abbie E Smith-Ryan
OBJECTIVE: This study characterized the impact of physical activity (light, moderate, and vigorous [VIG] active minutes per day) and body composition (percent body fat [%BF] and fat-free mass index) on total menopausal symptoms (TMSs) in 72 premenopausal, perimenopausal (PERI), or postmenopausal women. METHODS: Activity minutes were collected from wearable fitness trackers. Body composition was evaluated using a whole-body dual-energy x-ray absorptiometry scan. TMSs were quantified using The North American Menopause Society Questionnaire...
March 5, 2024: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/38441520/characteristics-of-systemic-testosterone-therapy-for-female-hypoactive-sexual-desire-disorder-a-claims-database-analysis
#24
JOURNAL ARTICLE
Pranjal Agrawal, Yeonsoo Sara Lee, Aurora J Grutman, Kathryn Dumas, Taylor Kohn, Jaden Kohn, Alyssa M Yee, Marisa Clifton
BACKGROUND: Testosterone therapy (TTh) is recommended for postmenopausal women with hypoactive sexual desire disorder (HSDD); however, there remain insufficient data to support use of TTh in premenopausal women with sexual dysfunction. AIM: In this study, we used a large national database to evaluate prescribing trends of TTh for women with HSDD. METHODS: We conducted a cohort analysis of information from electronic health records acquired from the data network TriNetX Diamond...
March 5, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38430610/characteristics-treatment-patterns-and-outcomes-in-patients-with-high-risk-locally-advanced-cervical-cancer
#25
JOURNAL ARTICLE
Francesca Coutinho, Mugdha Gokhale, Charlotte Doran, Matthew Monberg, Karin Yamada, Lei Chen
OBJECTIVE: To characterize the real-world treatment patterns and outcomes of patients with high-risk locally advanced cervical cancer (HR-LACC). METHODS: This retrospective study identified and randomly selected adults diagnosed between 2010 and 2018 from the ConcertAI Oncology Dataset. For patients initially treated with concurrent chemoradiotherapy (CCRT), we estimated real-world progression-free survival (rwPFS) among those with persistent disease, real-world time on CCRT, and recurrence-free survival (rwRFS) using Kaplan-Meier methods...
February 25, 2024: Cancer Treatment and Research Communications
https://read.qxmd.com/read/38423806/should-surgeons-reconsider-the-role-of-intraoperative-sentinel-lymph-node-evaluation-for-premenopausal-breast-cancer-patients-in-the-era-of-rxponder
#26
EDITORIAL
Chandler S Cortina, Amanda L Kong
No abstract text is available yet for this article.
February 17, 2024: American Journal of Surgery
https://read.qxmd.com/read/38422502/pregnancy-outcomes-after-laparoscopic-radiofrequency-ablation-of-uterine-leiomyomas-compared-with-myomectomy
#27
JOURNAL ARTICLE
Antoinette Allen, Michael Schembri, Ram Parvataneni, L Elaine Waetjen, Shira Varon, Naghmeh Salamat-Saberi, Shawn Tassone, Nicole Williams, Kimberly A Kho, Vanessa L Jacoby
OBJECTIVE: To compare pregnancy outcomes after laparoscopic radiofrequency ablation and myomectomy. METHODS: The ULTRA (Uterine Leiomyoma Treatment With Radiofrequency Ablation) study is an ongoing multicenter prospective cohort study with longitudinal follow-up up to 5 years comparing outcomes of radiofrequency ablation with myomectomy in premenopausal women older than age 21 years with symptomatic uterine leiomyomas. Participants were queried every 6 months after surgery to assess the incidence of pregnancy and pregnancy outcomes...
March 1, 2024: Obstetrics and Gynecology
https://read.qxmd.com/read/38421154/a-rare-case-of-metaplastic-breast-carcinoma-from-india-towards-precision-oncology
#28
Soirindhri Banerjee, Ishika Mahajan, Aruni Ghose, Stergios Boussios, Shivam Chakraborty
BACKGROUND: Metaplastic Breast Cancer (MpBC) is an exceedingly rare entity, accounting for less than 1% of all malignant breast tumours. Predominantly triple-negative, they are notorious for their chemoresistance, high rates of recurrence and decreased disease-free survival (DFS). All this contributes significantly to BC mortality and results in poor prognostic implications. Limited evidence has led to a lacuna of specific treatment guidelines for this entity and hence remains an uncharted territory for clinicians...
March 2024: Cancer reports
https://read.qxmd.com/read/38419670/bridging-information-gaps-in-menopause-status-classification-through-natural-language-processing
#29
JOURNAL ARTICLE
Hannah Eyre, Patrick R Alba, Carolyn J Gibson, Elise Gatsby, Kristine E Lynch, Olga V Patterson, Scott L DuVall
OBJECTIVE: To use natural language processing (NLP) of clinical notes to augment existing structured electronic health record (EHR) data for classification of a patient's menopausal status. MATERIALS AND METHODS: A rule-based NLP system was designed to capture evidence of a patient's menopause status including dates of a patient's last menstrual period, reproductive surgeries, and postmenopause diagnosis as well as their use of birth control and menstrual interruptions...
April 2024: JAMIA Open
https://read.qxmd.com/read/38416913/diabetic-fibrous-mastopathy-imaging-features-with-histopathologic-correlation
#30
JOURNAL ARTICLE
Priya B Patel, Gloria J Carter, Wendie A Berg
Diabetic fibrous mastopathy (DFM) is a rare benign fibrotic disease of the breast that develops in patients with longstanding and often uncontrolled diabetes mellitus. Clinically, patients may present with an irregular, firm, palpable mass, which may be solitary or multiple, occurring in one or both breasts. Diabetic fibrous mastopathy occurs most often in premenopausal women with heterogeneously or extremely dense breasts; mammography may show focal asymmetry or, less often, a noncalcified mass with indistinct or obscured margins, but there are usually no discrete findings...
September 22, 2023: Journal of breast imaging
https://read.qxmd.com/read/38414373/relationship-between-serum-total-testosterone-concentration-and-metabolic-syndrome-in-premenopausal-obese-women
#31
JOURNAL ARTICLE
Kyu-Jin Kim, Jun-Ho Lee, Seong-Ju Kim, Byung-Yeon Yu, Jee-Hyun Kang
BACKGROUND: Men with low testosterone levels are at an increased risk of developing metabolic syndrome, irrespective of age or obesity. However, the relationship between metabolic syndrome and testosterone levels in women remains unclear. We compared the total testosterone concentrations between premenopausal obese women with and without metabolic syndrome and identified the factors affecting these concentrations. METHODS: A single-center retrospective analysis was conducted using the medical records of 580 premenopausal women with obesity...
February 28, 2024: Korean Journal of Family Medicine
https://read.qxmd.com/read/38414048/estrogen-modulating-treatment-among-mid-life-women-and-covid-19-morbidity-and-mortality-a-multiregister-nationwide-matched-cohort-study-in-sweden
#32
JOURNAL ARTICLE
Evangelia Elenis, Helena Kopp Kallner, Maria A Karalexi, David Hägg, Marie Linder, Katja Fall, Fotios C Papadopoulos, Alkistis Skalkidou
BACKGROUND: It has been repeatedly shown that men infected by SARS-CoV-2 face a twofold higher likelihood of dying, being hospitalized or admitted to the intensive care unit compared to women, despite taking into account relevant confounders. It has been hypothesized that these discrepancies are related to sex steroid hormone differences with estrogens being negatively correlated with disease severity. The objective of this study was therefore to evaluate COVID-19-related mortality and morbidity among peri- and postmenopausal women in relation to estrogen-containing menopause hormonal treatments (MHT)...
February 27, 2024: BMC Medicine
https://read.qxmd.com/read/38413424/high-serum-levels-of-leucine-rich-%C3%AE-2-glycoprotein-1-lrg-1-are-associated-with-poor-survival-in-patients-with-early-breast-cancer
#33
JOURNAL ARTICLE
Andy Göbel, Tilman D Rachner, Oliver Hoffmann, Daniel Martin Klotz, Sabine Kasimir-Bauer, Rainer Kimmig, Lorenz C Hofbauer, Ann-Kathrin Bittner
BACKGROUND: Leucine-rich α-2 glycoprotein 1 (LRG-1) is a secreted glycoprotein that is mainly produced in the liver. Elevated levels of LRG-1 are found in a multitude of pathological conditions including eye diseases, diabetes, infections, autoimmune diseases, and cancer. In patients with early breast cancer (BC), high intratumoral LRG-1 protein expression levels are associated with reduced survival. In this study, we assessed serum levels of LRG-1 in patients with early BC and investigated its correlation with the presence of disseminated tumor cells (DTCs) in the bone marrow and survival outcomes...
February 28, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38407720/the-vaginal-microbiota-human-papillomavirus-infection-and-cervical-carcinogenesis-a-systematic-review-in-the-latina-population
#34
JOURNAL ARTICLE
Vianney Mancilla, Nicole R Jimenez, Naomi S Bishop, Melissa Flores, Melissa M Herbst-Kralovetz
BACKGROUND: Latina women experience disproportionately higher rates of HPV infection, persistence, and progression to cervical dysplasia and cancer compared to other racial-ethnic groups. This systematic review explores the relationship between the cervicovaginal microbiome and human papillomavirus infection, cervical dysplasia, and cervical cancer in Latinas. METHODS: The review abides by the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines...
February 26, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38406843/chronic-intermittent-hypoxia-induced-hypertension-the-impact-of-sex-hormones
#35
REVIEW
Cephas B Appiah, Jennifer J Gardner, George E Farmer, Rebecca L Cunningham, J Thomas Cunningham
Obstructive sleep apnea, a common form of sleep-disordered breathing, is characterized by intermittent cessations of breathing that reduce blood oxygen levels and contribute to the development of hypertension. Hypertension is a major complication of obstructive sleep apnea that elevates the risk of end-organ damage. Premenopausal women have a lower prevalence of obstructive sleep apnea and cardiovascular disease than men and postmenopausal women, suggesting that sex hormones play a role in the pathophysiology of sleep apnea-related hypertension...
February 26, 2024: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://read.qxmd.com/read/38403333/-mechanism-of-mitochondrial-dysfunction-in-polycystic-ovary-syndrome-and-traditional-chinese-medicine-intervention-a-review
#36
REVIEW
Ling-Jing Lu, Jiao Zhang, Yue Jiang, Yan-Hua Han, Yue-Hui Zhang
Polycystic ovary syndrome(PCOS) is a highly prevalent endocrine and reproductive disorder characterized by ovulatory dysfunction, hyperandrogenism(HA), and polycystic ovarian morphology(PCOM). It is often accompanied by insulin resistance(IR), obesity, and metabolic disorders and can lead to cardiovascular diseases, endometrial carcinoma and many other late complications, seriously affecting the physical and mental health and quality of life in premenopausal women. The etiology of PCOS is still unknown and many scholars assume that mitochondrial dysfunction may represent a major pathogenic factor in PCOS in recent years...
January 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38398165/prediction-of-a-multi-gene-assay-oncotype-dx-and-mammaprint-recurrence-risk-group-using-machine-learning-in-estrogen-receptor-positive-her2-negative-breast-cancer-the-brain-study
#37
JOURNAL ARTICLE
Jung-Hwan Ji, Sung Gwe Ahn, Youngbum Yoo, Shin-Young Park, Joo-Heung Kim, Ji-Yeong Jeong, Seho Park, Ilkyun Lee
This study aimed to develop a machine learning-based prediction model for predicting multi-gene assay (MGA) risk categories. Patients with estrogen receptor-positive (ER+)/HER2- breast cancer who had undergone Oncotype DX (ODX) or MammaPrint (MMP) were used to develop the prediction model. The development cohort consisted of a total of 2565 patients including 2039 patients tested with ODX and 526 patients tested with MMP. The MMP risk prediction model utilized a single XGBoost model, and the ODX risk prediction model utilized combined LightGBM, CatBoost, and XGBoost models through soft voting...
February 13, 2024: Cancers
https://read.qxmd.com/read/38397923/association-of-four-interleukin-8-polymorphisms-251-a-t-781-c-t-1633-c-t-2767-a-t-with-ovarian-cancer-risk-focus-on-menopausal-status-and-endometriosis-related-subtypes
#38
JOURNAL ARTICLE
Rafał Watrowski, Eva Schuster, Gerda Hofstetter, Michael B Fischer, Sven Mahner, Toon Van Gorp, Stefan Polterauer, Robert Zeillinger, Eva Obermayr
Interleukin-8 (IL-8) is involved in the regulation of inflammatory processes and carcinogenesis. Single-nucleotide polymorphisms (SNPs) within the IL-8 gene have been shown to alter the risks of lung, gastric, or hepatocellular carcinomas. To date, only one study examined the role of IL-8 SNPs in ovarian cancer (OC), suggesting an association between two IL-8 SNPs and OC risk. In this study, we investigated four common IL-8 SNPs, rs4073 (-251 A>T), rs2227306 (+781 C>T), rs2227543 (+1633 C>T), and rs1126647 (+2767 A>T), using the restriction fragment length polymorphism (PCR-RFLP) technique...
January 30, 2024: Biomedicines
https://read.qxmd.com/read/38396906/sex-dependent-differences-in-the-ischemia-reperfusion-induced-expression-of-ampa-receptors
#39
JOURNAL ARTICLE
Lindsay M Achzet, Darrell A Jackson
Following ischemia/reperfusion, AMPA receptors (AMPARs) mediate pathologic delayed neuronal death through sustained expression of calcium-permeable AMPARs, leading to excitotoxicity. Preventing the surface removal of GluA2-containing AMPARs may yield new therapeutic targets for the treatment of ischemia/reperfusion. This study utilized acute organotypic hippocampal slices from aged male and female Sprague Dawley rats and subjected them to oxygen-glucose deprivation/reperfusion (OGD/R) to examine the mechanisms underlying the internalization and degradation of GluA2-containing AMPARs...
February 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38396183/sexual-health-in-belgian-cervical-cancer-survivors-an-exploratory-qualitative-study
#40
JOURNAL ARTICLE
Eline Naert, Hans Van Hulle, Emiel A De Jaeghere, Marjolein R P Orije, Sarah Roels, Rawand Salihi, Koen J Traen, Kristien Watty, Lise-Marie Kinnaer, Hans Verstraelen, Philippe Tummers, Katrien Vandecasteele, Hannelore G Denys
PURPOSE: To assess experiences of sexuality and of receiving sexual healthcare in cervical cancer (CC) survivors. METHODS: A qualitative phenomenological study using semistructured one-on-one interviews was conducted with 15 Belgian CC survivors recruited in 5 hospitals from August 2021 to February 2022. The interviews were audiotaped and transcribed verbatim. Data were analyzed using inductive thematic analysis. COREQ and SRQR reporting guidelines were applied...
February 24, 2024: Quality of Life Research
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