keyword
MENU ▼
Read by QxMD icon Read
search

Premenopausal

keyword
https://www.readbyqxmd.com/read/28339573/augmented-h2s-production-via-cystathionine-beta-synthase-upregulation-plays-a-role-in-pregnancy-associated-uterine-vasodilation%C3%A2
#1
Lili Sheibani, Thomas J Lechuga, Honghai Zhang, Afshan Hameed, Deborah A Wing, Sathish Kumar, Charles R Rosenfeld, Dong-Bao Chen
Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor. The objectives of this study were to determine if human uterine artery (UA) H2S production increases with augmented expression and/or activity of CBS and/or CSE during the menstrual cycle and pregnancy and whether exogenous H2S dilates UA. Uterine arteries from nonpregnant (NP) premenopausal proliferative (pPRM) and secretory (sPRM) phases of the menstrual cycle and pregnant (P) women were studied...
January 24, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28337704/analysis-of-traditional-and-emerging-risk-factors-in-premenopausal-women-with-coronary-artery-disease-a-pilot-scale-study-from-north-india
#2
Rajesh Vijayvergiya, Divya Kapoor, Ajay Aggarwal, Sonal Sangwan, Vanita Suri, Veena Dhawan
Premenopausal women are known to have less heart disease than their menopausal counterparts and men. However, there is a rising prevalence of coronary artery disease (CAD) in premenopausal females, which necessitates determination of risk factors that negate the effects of hormonal protection. There are few studies describing the prevalence of traditional and emerging risk factors in premenopausal women with CAD. Thus, our objective was to explore the prevalence of traditional and emerging risk factors and features of coronary lesions in premenopausal women with CAD in an Indian population...
March 23, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28333842/review-article-sexuality-and-risk-reducing-salpingo-oophorectomy
#3
Paige E Tucker, Paul A Cohen
INTRODUCTION: Women with familial cancer syndromes such as hereditary breast and ovarian cancer syndrome (BRCA1 and BRCA2) and Lynch syndrome are at a significantly increased risk of developing ovarian cancer and are advised to undergo prophylactic removal of their ovaries and fallopian tubes at age 35 to 40 years, after childbearing is complete. METHODS: A comprehensive literature search of studies on risk-reducing salpingo-oophorectomy (RRSO), sexuality, and associated issues was conducted in MEDLINE databases...
March 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28333356/the-safety-and-efficacy-of-controlled-ovarian-hyperstimulation-for-fertility-preservation-in-women-with-early-breast-cancer-a-systematic-review
#4
Rachael J Rodgers, Geoffrey D Reid, Juliette Koch, Rebecca Deans, William L Ledger, Michael Friedlander, Robert B Gilchrist, Kirsty A Walters, Jason A Abbott
STUDY QUESTION: Can controlled ovarian hyperstimulation (COH) for fertility preservation be effectively conducted in women with breast cancer without worsening their prognosis? SUMMARY ANSWER: COH with co-administration of letrozole suppresses oestradiol levels without significantly impacting oocyte yield or decreasing disease-free survival rates. WHAT IS KNOWN ALREADY: Oestradiol has the capacity to stimulate the proliferation of breast cancer cells...
February 27, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333318/a-phase-iii-randomized-controlled-trial-comparing-the-efficacy-safety-and-tolerability-of-oral-dydrogesterone-versus-micronized-vaginal-progesterone-for-luteal-support-in-in-vitro-fertilization
#5
Herman Tournaye, Gennady T Sukhikh, Elke Kahler, Georg Griesinger
STUDY QUESTION: Is oral dydrogesterone 30 mg daily (10 mg three times daily [TID]) non-inferior to micronized vaginal progesterone (MVP) 600 mg daily (200 mg TID) for luteal support in in vitro fertilization (IVF), assessed by the presence of fetal heartbeats determined by transvaginal ultrasound at 12 weeks of gestation? SUMMARY ANSWER: Non-inferiority of oral dydrogesterone versus MVP was demonstrated at 12 weeks of gestation, with a difference in pregnancy rate and an associated confidence interval (CI) that were both within the non-inferiority margin...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28331765/background-parenchymal-enhancement-and-fibroglandular-tissue-proportion-on-breast-mri-correlation-with-hormone-receptor-expression-and-molecular-subtypes-of-breast-cancer
#6
Mesut Öztürk, Ahmet Veysel Polat, Yurdanur Süllü, Leman Tomak, Ayfer Kamalı Polat
OBJECTIVE: To assess the relationship between background parenchymal enhancement (BPE) and fibroglandular tissue (FGT) proportion on breast magnetic resonance imaging (MRI) and hormone receptor expression and molecular subtypes in invasive breast cancer. MATERIALS AND METHODS: This retrospective study enrolled 75 breast cancer patients who underwent breast MRI before treatment. T1-weighted images were reviewed to determine the FGT proportion, and contrast-enhanced fat-suppressed T1-weighted images were reviewed to determine BPE...
January 2017: J Breast Health (2013)
https://www.readbyqxmd.com/read/28329428/the-diagnosis-and-lived-experience-of-polycystic-ovary-syndrome-a-qualitative-study
#7
Julie Tomlinson, Jonathan Pinkney, Linda Adams, Elizabeth Stenhouse, Alison Bendall, Oonagh Corrigan, Gayle Letherby
AIMS: To explore the impact of the diagnosis of polycystic ovary syndrome on health/ill health identity, how women experience this diagnosis and their health beliefs. BACKGROUND: polycystic ovary syndrome is a common and heterogeneous condition, giving rise to a wide range of different health concerns. Previous research on polycystic ovary syndrome has been dominated by the medical perspective and less is known about the experiences and needs of women. DESIGN: A qualitative study of 32 premenopausal adult women with polycystic ovary syndrome (diagnosis confirmed by Rotterdam criteria), aged between 18-45 years, recruited from a primary and secondary care setting...
March 22, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28329133/bilateral-oophorectomy-and-accelerated-aging-cause-or-effect
#8
Walter A Rocca, Liliana Gazzuola Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, James L Kirkland, Elizabeth A Stewart, Virginia M Miller
Background: The cause-effect relationship between bilateral oophorectomy and accelerated aging remains controversial. We conducted new analyses to further address this controversy. Methods: The Rochester Epidemiology Project records-linkage system was used to identify all premenopausal women who underwent bilateral oophorectomy for a noncancerous condition before age 50 years between 1988 and 2007 in Olmsted County, MN. Each woman was randomly matched to a referent woman born in the same year (±1 year) who had not undergone bilateral oophorectomy...
February 28, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28325536/self-reported-neuropathic-pain-characteristics-of-women-with-provoked-vulvar-pain-a-preliminary-investigation
#9
Emma Dargie, Ian Gilron, Caroline F Pukall
BACKGROUND: Provoked vestibulodynia (PVD) is a common chronic genital pain condition affecting approximately 12% of premenopausal women. Although parallels have been drawn between PVD and neuropathic pain (NP), no studies have examined self-reported NP characteristics in PVD. AIM: To explore pain symptoms that resemble NP reported by those with PVD and compare responses with those with an established NP condition. METHODS: Women with provoked vulvar pain (PVP; n = 65) completed online questionnaires designed to assess characteristics of NP...
March 15, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28323981/ovarian-lipid-metabolism-modulates-circulating-lipids-in-premenopausal-women
#10
Jeffrey T Jensen, Ilana B Addis, Jon D Hennebold, Randy L Bogan
Context: The premenopausal circulating lipid profile may be linked to the hormonal profile and ovarian lipid metabolism. Objective: Assess how estradiol, progesterone, and ovarian lipid metabolism contribute to the premenopausal lipid profile. Also, evaluate the acute effects of a common hormonal oral contraceptive (OC) on circulating lipids. Design: Experimental crossover with repeated measures. Setting: Academic hospitals...
January 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323948/dose-dependent-suppression-of-gonadotropins-and-ovarian-hormones-by-elagolix-in-healthy-premenopausal-women
#11
Juki Ng, Kristof Chwalisz, David C Carter, Cheri E Klein
Context: Elagolix is a nonpeptide, oral gonadotropin-releasing hormone (GnRH) antagonist being developed for sex-hormone dependent diseases in women. Objective: To evaluate the pharmacokinetics and pharmacodynamics of elagolix. Design, Setting, and Participants: Randomized, double-blind, placebo-controlled, multiple-ascending dose study in 45 healthy premenopausal women at a research unit. Interventions: Elagolix 150 mg once daily or 100, 200, 300 or 400 mg twice daily or placebo for 21 days...
February 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323926/psychological-distress-is-more-prevalent-in-fertile-age-and-premenopausal-women-with-pcos-symptoms-15-yr-follow-up
#12
Salla Karjula, Laure Morin-Papunen, Juha Auvinen, Aimo Ruokonen, Katri Puukka, Stephen Franks, Marjo-Riitta Järvelin, Juha S Tapanainen, Jari Jokelainen, Jouko Miettunen, Terhi T Piltonen
Context: Polycystic ovary syndrome (PCOS) is associated with increased psychological distress; obesity and hyperandrogenism being suggested as key promoters. Objectives: To investigate the prevalence of anxiety/depression and their coexistence in women with PCOS/PCOS symptoms at ages 31 and 46. The roles of obesity, hyperandrogenism and awareness of PCOS on psychological distress were also assessed. Design: Population based follow-up. Setting: Northern Finland Birth Cohort 1966 with 15-year follow-up...
February 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323914/menopause-is-a-determinant-of-breast-aromatase-expression-and-its-associations-with-bmi-inflammation-and-systemic-markers
#13
Kristy A Brown, Neil M Iyengar, Xi Kathy Zhou, Ayca Gucalp, Kotha Subbaramaiah, Hanhan Wang, Dilip D Giri, Monica Morrow, Domenick J Falcone, Nils K Wendel, Lisle A Winston, Michael Pollak, Anneloor Dierickx, Clifford A Hudis, Andrew J Dannenberg
CONTEXT: Most estrogen-dependent breast cancers occur after menopause despite low levels of circulating estrogens. Breast expression of the estrogen-biosynthetic enzyme, aromatase, is proposed to drive breast cancer development after menopause. However, the effects of menopause on breast aromatase expression are unknown. OBJECTIVE: To determine the effect of menopause on breast aromatase expression in relation to body mass index (BMI), white adipose tissue inflammation (WATi) and systemic markers of metabolic dysfunction...
February 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323624/conventional-or-natural-pharmacotherapy-and-the-prevalence-of-anxiety-and-depression-during-menopause
#14
Dorota Kopciuch, Anna Paczkowska, Tomasz Zaprutko, Michał Michalak, Elżbieta Nowakowska
Context • Psychoneurological symptoms are present in nearly all women in the perimenopausal period. Key elements of care in the period may include hormone replacement therapy (HRT). Alternatively, phytoestrogens, antidepressant pharmacotherapy, or a combination of hormonal and antidepressant therapies may be recommended. Objective • The study intended to verify whether women who are menopausal believe that a reduction in their symptoms of anxiety and depression depends on the type of pharmacotherapy used...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28321018/coronary-artery-disease-in-premenopausal-and-postmenopausal-women
#15
Lu Yihua, Jiang Yun, Zhao Dongshen
The purpose was to determine the differences between premenopausal and postmenopausal coronary artery disease (CAD) risk factors, clinical manifestation, cardiovascular features, rates of recurrence, and influencing factors.Premenopausal (n = 57) and postmenopausal (n = 178) CAD women hospitalized during the same period were enrolled. All patients were followed-up, and the combined recurrence of major adverse cardiovascular events was recorded as the clinical outcome. Differences were compared between the 2 groups...
March 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28320479/correlates-of-circulating-ovarian-cancer-early-detection-markers-and-their-contribution-to-discrimination-of-early-detection-models-results-from-the-epic-cohort
#16
Renée T Fortner, Allison F Vitonis, Helena Schock, Anika Hüsing, Theron Johnson, Raina N Fichorova, Titilayo Fashemi, Hidemi S Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Carlo La Vecchia, Domenico Palli, Sabina Sieri, Rosario Tumino, Giuseppe Matullo, Amalia Mattiello, N Charlotte Onland-Moret, Petra H Peeters, Elisabete Weiderpass, Inger Torhild Gram, Mie Jareid, J Ramón Quirós, Eric J Duell, Maria-Jose Sánchez, María Dolores Chirlaque, Eva Ardanaz, Nerea Larrañaga, Björn Nodin, Jenny Brändstedt, Annika Idahl, Kay-Tee Khaw, Naomi Allen, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A Merritt, Elio Riboli, Daniel W Cramer, Rudolf Kaaks, Kathryn L Terry
BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases)...
March 20, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28318328/estrogen-induces-cxcr4-overexpression-and-cxcr4-cxl12-pathway-activation-in-lung-adenocarcinoma-cells-in-vitro
#17
Vianey Rodriguez-Lara, González-Sánchez Ignacio, Marco A Cerbón Cervantes
PURPOSE: This study was designed to investigate whether estradiol is related to the expression of the chemokine receptor CXCR4 and its activation in lung adenocarcinoma in vitro, since lung adenocarcinomas from premenopausal women have shown high levels of CXCR4, and this expression has been associated with worse prognosis and poor survival. METHODS: The effect of 17-β-estradiol (E2) (0.03 nM-10 nM) on CXCR4 expression was analyzed in lung adenocarcinoma cell lines (SK-LU-1, H1435, H23, A549) by immunofluorescence after 24 and 72-h poststimulation...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28317900/hypertension-and-breast-cancer-risk-a-systematic-review-and-meta-analysis
#18
Hedong Han, Wei Guo, Wentao Shi, Yamei Yu, Yunshuo Zhang, Xiaofei Ye, Jia He
Observational studies examining the relationship between hypertension and breast cancer risk have reported conflicting findings. We conducted this systematic review and meta-analysis to summarize the evidence regarding the association between hypertension and risk of breast cancer. Eligible studies were identified through a comprehensive literature search of PubMed, EMBASE, and the Cochrane library until August 2016. We included observational studies that reported relative risks (RR) with corresponding 95% confidence intervals (CIs)...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28315227/insulin-like-growth-factor-1-gene-polymorphism-in-women-with-breast-cancer
#19
Danylo Rafhael Costa-Silva, Maria da Conceição Barros-Oliveira, Rafael Soares Borges, Larysse Maira Campos-Verdes, João Paulo da Silva-Sampaio, Carla Solange Escorcio-Dourado, Luana Mota Martins, Airlane Pereira Alencar, Edmund Chada Baracat, Vladimir Costa Silva, Benedito Borges da Silva
Breast cancer is a disease of unknown etiology; however, the major risk factors are genetic alterations. Studies have demonstrated an association between insulin-like growth factor 1 (IGF-1) gene polymorphism and cell proliferation and reduced apoptosis, in addition to its role in breast cancer growth and aggressiveness. Two polymorphic variants of the IGF-1 gene are highlighted in association with breast cancer, rs6220 and rs7136446, although controversy exists as to this relationship. The current study included 137 women (68 breast cancer cases and 69 controls without breast cancer) who had 3 ml of peripheral blood drawn for the study of genomic DNA extracted from leukocytes using the genotyping technique by real-time polymerase chain reaction...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28314254/synchronous-endometrial-and-ovarian-cancer-in-young-women-case-report-and-review-of-the-literature
#20
REVIEW
Askin Dogan, Beate Schultheis, Günther A Rezniczek, Ziad Hilal, Cem Cetin, Günther Häusler, Clemens B Tempfer
BACKGROUND: Young women with endometrial cancer (EC) have an increased risk of synchronous ovarian cancer. The prognosis of women with synchronous endometrial and ovarian cancer (SEOC) is good. A high proportion of affected women have hereditary non-polyposis colon cancer syndrome (HNPCC). CASE PRESENTATION: We present the case of a 45-year-old woman with histologically proven endometrioid adenocarcinoma of the endometrium (pT1B, G2, R0 without lymphovascular space invasion)...
March 2017: Anticancer Research
keyword
keyword
13421
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"