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https://www.readbyqxmd.com/read/29677309/vitamin-d-calcium-or-combined-supplementation-for-the-primary-prevention-of-fractures-in-community-dwelling-adults-us-preventive-services-task-force-recommendation-statement
#1
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005, and annual incidence is projected to increase to more than 3 million fractures by 2025. Within 1 year of experiencing a hip fracture, many patients are unable to walk independently, more than half require assistance with activities of daily living, and 20% to 30% of patients will die...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29674762/current-multidisciplinary-approach-to-fertility-preservation-for-breast-cancer-patients
#2
Yuko Takahashi, Tadahiko Shien, Ai Sakamoto, Yuko Tsuyumu, Ryo Yoshioka, Maya Uno, Minami Hatono, Mariko Kochi, Kengo Kawada, Takahiro Tsukioki, Takayuki Iwamoto, Hirokuni Ikeda, Naruto Taira, Junji Matsuoka, Mikiya Nakatsuka, Hiroyoshi Doihara
Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29673835/effects-of-ovarian-reserve-and-hormone-therapy-on-hearing-in-premenopausal-and-postmenopausal-women-a-cross-sectional-study
#3
Jingfei Zhang, Tingyue Zhang, Lisheng Yu, Qianying Ruan, Lingxue Yin, Dong Liu, Haicheng Zhang, Wenpei Bai, Zhenghong Ren
OBJECTIVES: To observe the hearing function around menopause, to analyze the effects of ovarian reserve and hormone therapy on hearing, and to study factors related to hearing loss among women around menopause. STUDY DESIGN: In this cross-sectional study, we evaluated 109 women around menopause aged 45-55 years, including 40 women with ovarian failure, 48 with ovarian non-failure, and 21 receiving hormone therapy. All women underwent an audiologic evaluation, and hormone blood testing was performed...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29673834/severity-and-duration-of-menopausal-symptoms-after-risk-reducing-salpingo-oophorectomy
#4
A Stuursma, C M G van Driel, N J Wessels, G H de Bock, M J E Mourits
OBJECTIVES: To reduce the risk of ovarian cancer, women with BRCA1/2 mutations are advised to undergo risk-reducing salpingo-oophorectomy (RRSO) at a premenopausal age. Premenopausal RRSO results in acute menopause and is associated with various menopausal symptoms. This study investigates the severity and duration of subjective menopausal symptoms after premenopausal RRSO and associated factors. METHODS: We included 199 women who had undergone RRSO before age 52 in this cross-sectional study...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29673111/comparison-of-epidemiological-features-clinicopathological-features-and-treatments-between-premenopausal-and-postmenopausal-female-breast-cancer-patients-in-western-china-a-retrospective-multicenter-study-of-15-389-female-patients
#5
REVIEW
Fan Feng, Yuxian Wei, Ke Zheng, Yujing Li, Lu Zhang, Tielin Wang, Yanli Zhang, Hongyuan Li, Guosheng Ren, Fan Li
Premenopausal and postmenopausal breast cancers are considered different types. Thus, this study aimed to explore differences in risk factors, epidemiological features, clinicopathological features, and treatment modes of premenopausal breast cancer compared to postmenopausal patients in western China. This was a hospital-based, retrospective, multicenter epidemiological study of patients with breast cancer. Using the Western China Clinical Cooperation Group database, we obtained the records of 15,389 female breast cancers between January 2010 and April 2017...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29670473/determination-of-the-reference-values-of-the-tumor-marker-he4-in-female-population-of-canton-sarajevo
#6
Lejla Hasanbegovic, Nedeljka Sljivo
Introduction: Ovarian cancer has the highest mortality rate of all gynecological tumors and represent fifth leading cause of cancer death in women, due to the absence of early symptoms of the disease and the lack of screening tests. A new HE4 ovarian cancer biomarker was found in various studies, with different populations having quite different sensitivity and specificity values as well as reference values. The tumor marker HE4 is a useful marker for ovarian cancer detection with only minimal expression in normal ovarian tissue...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29670382/clinical-outcomes-and-health-care-utilization-pre-and-post-laparoscopic-radiofrequency-ablation-of-symptomatic-fibroids-and-laparoscopic-myomectomy-a-randomized-trial-of-uterine-sparing-techniques-trust-in-canada
#7
Darrien D Rattray, Laura Weins, Lexy C Regush, James M Bowen, Daria O'Reilly, John A Thiel
Objective: The objective of this study was to compare laparoscopic ultrasound-guided radiofrequency ablation of fibroids (Lap-RFA) and laparoscopic myomectomy in terms of 1) health care utilization and 2) serious complication rates. The secondary objectives were comparison of subject responses to validated symptom and quality-of-life questionnaires. We hypothesized that Lap-RFA health care utilization and clinical outcomes would not be worse than those of laparoscopic myomectomy in the aggregate...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29662718/is-the-measurement-of-the-size-of-uterine-lesions-with-positron-emission-tomography-consistent-in-pre-and-postmenopausal-periods-in-endometrioid-type-endometrial-cancer
#8
Varol Gülseren, Mustafa Kocaer, Özgü Çelikkol Güngördük, İsa Aykut Özdemir, Muzaffer Sancı, Kemal Güngördük
Objective: We aimed to investigate the correlation of the size and volume of uterine tumors obtained using positron emission tomography/computed tomography (PET/CT) and pathology specimens in patients with endometrioid-type endometrial cancer (EEC) in the premenopausal period, and to compare the results with those of postmenopausal women. In the premenopausal period, the endometrium uses more glucose than in the postmenopausal period. Therefore, the measurement of uterine tumor size using PET/CT in the premenopausal period may normally be different...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29661801/anti-ca15-3-and-anti-ca125-antibodies-and-ovarian-cancer-risk-results-from-the-epic-cohort
#9
Daniel W Cramer, Raina N Fichorova, Kathryn L Terry, Hidemi S Yamamoto, Allison F Vitonis, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Jenny Brändstedt, Marie-Christine Boutron-Ruault, Maria-Dolores Chirlaque, Miren Dorronsoro, Laure Dossus, Eric J Duell, Inger T Gram, Marc J Gunter, Louise Hansen, Annika Idahl, Theron Johnson, Kay-Tee Khaw, Vittorio Korgh, Marina Kvaskoff, Amalia Mattiello, Giuseppe Matullo, Melissa A Merritt, Björn Nodin, N Charlotte Onland-Moret, Philippos Orfanos, Domenico Palli, Eleni Peppa, J Ramón Quirós, Maria-José Sànchez-Pérez, Gianluca Severi, Ruth C Travis, Antonia Trichopoulou, Rosario Tumino, Elisabete Weiderpass, Renée Turzanski Fortner, Rudolf Kaaks
BACKGROUND: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3 and CA125, and generate antibodies against them; but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined. METHODS: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression...
April 16, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29659835/anti-m%C3%A3-llerian-hormone-levels-and-incidence-of-early-natural-menopause-in-a-prospective-study
#10
Elizabeth R Bertone-Johnson, JoAnn E Manson, Alexandra C Purdue-Smithe, Anne Z Steiner, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Brian W Whitcomb
STUDY QUESTION: Are anti-Müllerian hormone (AMH) levels assessed in women aged 32-44 associated with risk of incident early natural menopause? SUMMARY ANSWER: We observed strong, significant associations between lower AMH levels and higher risk of early menopause. WHAT IS KNOWN ALREADY: The ability to predict risk early menopause, defined as menopause before age 45, prior to fertility decline would improve options for family planning and cardiovascular disease prevention...
April 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29658110/prenatal-diethylstilbestrol-des-exposure-and-mammographic-density
#11
William C Strohsnitter, Kimberly A Bertrand, Rebecca Troisi, Christopher G Scott, Andrea L Cheville, Robert N Hoover, Julie R Palmer, Celine M Vachon
In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort of DES-exposed and unexposed women was assembled at the Mayo Clinic in 1975, and followed through 2012 as part of the National Cancer Institute's DES Follow-up Study. Mammographic density from 3,637 mammograms for 332 (222 DES-exposed, 110 unexposed) women in this cohort screened at the Mayo Clinic, Rochester between 1996 and 2015 were determined clinically using the Breast Imaging Reporting and Data System (BI-RADS)...
April 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29657446/assessment-of-the-risk-of-low-bone-mineral-density-in-premenopausal-japanese-female-patients-with-systemic-lupus-erythematosus
#12
Yu Mori, Kazuyoshi Baba, Atsushi Kogure, Takuya Izumiyama, Michiharu Matsuda, Naoko Mori, Tomonori Ishii, Eiji Itoi
Background: The aim of this study was to assess the relationships between clinical parameters and bone mineral density (BMD) in Japanese female patients with systemic lupus erythematosus (SLE). Methods: A total of female 136 SLE patients without menopause were retrospectively assessed to identify associations between age, disease duration, body mass index (BMI), glucocorticoid usage and disease activity and BMD based on the treatment with or without bisphosphonate...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656764/prescribing-habits-for-androgenic-alopecia-among-dermatologists-in-spain-in-2017-a-cross-sectional-study
#13
C Pindado-Ortega, D Saceda-Corralo, D Buendía-Castaño, P Fernández-González, Ó M Moreno-Arrones, P Fonda-Pascual, A Alegre-Sánchez, A R Rodrigues-Barata, S Vañó-Galván
BACKGROUND: Topical minoxidil and oral finasteride are the only drugs approved for the treatment of androgenetic alopecia (AGA) in Spain. However, the management of this condition is highly variable because numerous treatments are used off-label. The main aim of this study was to describe the prescribing habits of dermatologists in Spain for male AGA (MAGA) and female AGA (FAGA). MATERIAL AND METHODS: Descriptive cross-sectional study using online questionnaires completed by dermatologists working in Spain...
April 12, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29649080/investigating-changes-in-weight-and-body-composition-among-women-in-adjuvant-treatment-for-breast-cancer-a-scoping-review
#14
Birgith Pedersen, Charlotte Delmar, Tamás Lörincz, Ursula Falkmer, Mette Grønkjær
BACKGROUND: Despite several investigations, findings on weight changes during and after adjuvant treatment for breast cancer are diverse and point in several directions. OBJECTIVE: The aims of this study were to investigate changes in weight and body composition associated with contemporary anticancer medication and to examine factors that might influence the assessment and diversity of the findings. METHODS: This article used the method of a scoping review to map the body of literature...
April 12, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29644960/glucosinolate-and-isothiocyanate-intakes-are-inversely-associated-with-breast-cancer-risk-a-case-control-study-in-china
#15
Nai-Qi Zhang, Suzanne C Ho, Xiong-Fei Mo, Fang-Yu Lin, Wu-Qing Huang, Hong Luo, Jing Huang, Cai-Xia Zhang
Although previous studies have investigated the association of cruciferous vegetable consumption with breast cancer risk, few studies focused on the association between bioactive components in cruciferous vegetables, glucosinolates (GSL) and isothiocyanates (ITC), and breast cancer risk. This study aimed to examine the association between consumption of cruciferous vegetables and breast cancer risk according to GSL and ITC contents in a Chinese population. A total of 1485 cases and 1506 controls were recruited into this case-control study from June 2007 to March 2017...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29642332/re-non-alcoholic-fatty-liver-disease-as-a-risk-factor-for-female-sexual-dysfunction-in-premenopausal-women
#16
Allen D Seftel
No abstract text is available yet for this article.
April 2018: Journal of Urology
https://www.readbyqxmd.com/read/29629038/the-association-between-fat-mass-lean-mass-and-bone-mineral-density-in-premenopausal-women-in-korea-a-cross-sectional-study
#17
Jeehyun Kim, Hyuktae Kwon, Bo-Kyoung Heo, Hee-Kyung Joh, Cheol Min Lee, Seung-Sik Hwang, Danbee Park, Jae-Hong Park
Background: We investigated the association between body composition, especially truncal or non-truncal fat mass (FM), and bone mineral density (BMD) in premenopausal women in Korea. Methods: A cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey IV and V (2008-2011). Total lean mass (LM), total FM (TFM), truncal FM, and non-truncal FM, and BMD of the total femur, femoral neck (FN), and lumbar spine were measured using dual-energy X-ray absorptiometry...
March 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29627127/the-action-of-estrogens-and-progestogens-in-the-young-female-breast
#18
Irene Zolfaroli, Juan J Tarín, Antonio Cano
Evidence from different sources sustains a pro-oncogenic role of hormones, estrogens and progestogens, on the breast. The issue is of interest for young women, who are exposed to the hormonal changes imposed by the ovarian cycle and, often, take hormones with contraceptive purposes. Experimental and clinical studies show that both estrogens and progesterone are involved in mammary development during puberty and lactation, the changes being observed across mammalian species, including humans. Estrogen receptors, and more particularly the alpha isoform, participate in molecular processes of stem cells differentiation and epithelial proliferation through paracrine actions implicating growth factors...
March 28, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29626678/ulipristal-acetate-improves-clinical-symptoms-in-women-with-adenomyosis-and-uterine-fibroids
#19
Meritxell Gracia, Marta Alcalà, Janisse Ferreri, Mariona Rius, Cristina Ros, María Adela Saco, María Ángeles Martínez-Zamora, Francisco Carmona
STUDY OBJECTIVE: To study the effects of ulipristal acetate (UPA) on adenomyosis-associated clinical symptoms. DESIGN: A retrospective, single-center observational study. (Canadian Task Force Classification II-2). SETTING: A university tertiary referral center. PATIENTS: Premenopausal women (163) with adenomyosis and symptomatic uterine fibroids (41 patients, A+F group) versus a control group with only fibroids (122 patients, F group) treated with the first course of UPA...
April 4, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29626240/mammographic-density-changes-following-discontinuation-of-tamoxifen-in-premenopausal-women-with-oestrogen-receptor-positive-breast-cancer
#20
Won Hwa Kim, Nariya Cho, Young-Seon Kim, Ann Yi
OBJECTIVES: To evaluate the changes in mammographic density after tamoxifen discontinuation in premenopausal women with oestrogen receptor-positive breast cancers and the underlying factors METHODS: A total of 213 consecutive premenopausal women with breast cancer who received tamoxifen treatment after curative surgery and underwent three mammograms (baseline, after tamoxifen treatment, after tamoxifen discontinuation) were included. Changes in mammographic density after tamoxifen discontinuation were assessed qualitatively (decrease, no change, or increase) by two readers and measured quantitatively by semi-automated software...
April 6, 2018: European Radiology
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