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https://www.readbyqxmd.com/read/29027715/diagnostic-performance-of-human-epididymis-protein-4-compared-to-a-combination-of-biophysical-and-biochemical-markers-to-differentiate-ovarian-endometriosis-from-epithelial-ovarian-cancer-in-premenopausal-women
#1
Tanja Nikolova, Radomir Zivadinovic, Nina Evtimovska, Violeta Klisarovska, Marko Stanojevic, Jadranka Georgievska, Natasha Nikolova
AIM: This study is a comparison of human epididymis protein 4 (HE4) with cancer antigen 125 (CA125), using the Risk of Ovarian Malignancy Algorithm (ROMA), Copenhagen Index (CPH-I), Risk of Malignancy Index (RMI) and Morphology Index (MI) to differentiate ovarian endometriosis from epithelial ovarian cancer (EOC) in premenopausal women. METHODS: The study was performed at the University Clinic of Obstetrics and Gynecology in Skopje. One hundred and sixty-four premenopausal patients were divided into three study groups, including ovarian endometriosis (37), other benign pelvic masses (57) and EOCs (11), and a control group (59)...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29027349/aerobic-exercise-training-lowers-platelet-reactivity-and-improves-platelet-sensitivity-to-prostacyclin-in-pre-and-postmenopausal-women
#2
M H Lundberg Slingsby, M Nyberg, J Egelund, C M Mandrup, R Frikke-Schmidt, N S Kirkby, Y Hellsten
BACKGROUND: The risk of atherothrombotic events increases after menopause. Regular physical activity has been shown to reduce platelet reactivity in younger women, but it is unknown how regular exercise affects platelet function after menopause. OBJECTIVES: To examine the effects of regular aerobic exercise in late pre- and recent postmenopausal women by testing basal platelet reactivity and platelet sensitivity to prostacyclin and nitric oxide. METHODS: 25 sedentary, but healthy, late premenopausal and 24 matched recently postmenopausal women, mean (95% confidence interval) 49...
October 12, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29024986/stromal-fibroblasts-from-perimenopausal-endometrium-exhibit-a-different-transcriptome-than-those-from-the-premenopausal-endometrium
#3
David W Erikson, Fatima Barragan, Terhi T Piltonen, Joseph C Chen, Shaina Balayan, Juan C Irwin, Linda C Giudice
Human endometrium undergoes extensive regeneration on a cyclic basis in premenopausal women and likely occurs through the contribution of stem/progenitor cells. Menopause results in the permanent cessation of menstrual cycles and is preceded by perimenopause, a period of several years in which endocrine and biological changes occur and is a period of risk for endometrial proliferative disorders. The objectives of this study were to identify mesenchymal stem cells (eMSC) and stromal fibroblasts (eSF) in endometrium of perimenopausal women and perform expression profile analysis of perimenopausal eMSC and eSF to gain insight into the biology of stem/progenitor and lineage cell populations during the transition to menopause...
August 19, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024822/pubertally-initiated-high-fat-diet-promotes-mammary-tumorigenesis-in-obesity-prone-fvb-mice-similarly-to-obesity-resistant-balb-c-mice
#4
Yirong Zhu, Mark D Aupperlee, Sandra Z Haslam, Richard C Schwartz
Premenopausal breast cancer is associated with increased animal fat consumption among normal-weight but not overweight women. Our previous findings in obesity-resistant BALB/c mice showed that a diet high in saturated animal fat (HFD) promotes mammary tumorigenesis in both DMBA carcinogenesis and Trp53-null transplant models. Having made these observations in BALB/c mice, which have very modest HFD weight gain, we determined the effects of HFD in FVB mice, which gain significant weight on HFD. Three-week-old FVB mice fed a low-fat diet or HFD were subjected to 7,12-dimethylbenz[a]anthracene-induced carcinogenesis...
October 9, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29023178/effect-of-calcium-derived-from-lithothamnion-sp-on-markers-of-calcium-metabolism-in-premenopausal-women
#5
John L Zenk, Joy L Frestedt, Michael A Kuskowski
A double-blind crossover pilot trial tested the hypothesis that botanically derived calcium could demonstrate greater influence over calcium metabolism markers compared with a nonplant-derived calcium carbonate supplement or placebo. Twelve fasting female subjects received a single oral dose of Aquamin F™ (derived from the marine algal Lithothamnion sp.), or calcium carbonate, or placebo. Blood and urine samples were collected at baseline and over 12 h to evaluate ionized and total calcium and parathyroid hormone (PTH)...
October 12, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29021083/fertility-preserving-surgery-for-advanced-stage-ovarian-germ-cell-tumors
#6
Dimitrios Nasioudis, Melissa K Frey, Eloise Chapman-Davis, Thomas A Caputo, Kevin Holcomb
OBJECTIVE: To evaluate the prevalence and safety of uterine preservation among premenopausal women diagnosed with a malignant ovarian germ-cell tumor (MOGCT) of advanced stage (stage II-IV). MATERIALS AND METHODS: The National Cancer Database was accessed and a cohort of women aged <40years, diagnosed with a MOGCT were identified. Those with stage II-IV disease who underwent cancer-directed surgery and received chemotherapy were selected for further analysis...
October 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29020786/-what-is-the-risk-of-pelvic-organ-prolapse-recurrence-after-vaginal-hysterectomy-with-colporrhaphy
#7
M Nováčková, Z Pastor, T Brtnický, R Chmel
OBJECTIVE: To determine the risk of prolapse recurrence in patients after vaginal hysterectomy with colporrhaphy. DESIGN: Retrospective clinical study. SETTING: Department of Obstetrics and Gynaecology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague. METHODS: The trial involved 220 women who underwent vaginal hysterectomy with anterior and posterior kolporrhaphy at our department for uterine prolapse at least grade 2...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29020170/breast-cancer-incidence-and-metalworking-fluid-exposure-in-a-cohort-of-female-autoworkers
#8
Erika Garcia, Patrick T Bradshaw, Ellen A Eisen
Breast cancer is the leading cancer diagnosed among women and environmental studies have produced few leads on modifiable risk factors. Following an Institute of Medicine recommendation for occupational studies of highly exposed women, we took advantage of an existing cohort of 4,503 female hourly autoworkers in Michigan exposed to metalworking fluid (MWF), complex mixtures of oils and chemicals widely used in metal manufacturing worldwide. Cox proportional hazards models were fit to estimate hazard ratios (HR) for incident breast cancer (follow-up 1985-2013) and cumulative exposure (20-year lag) to straight mineral oils (a known human carcinogen), and water-based soluble and synthetic MWF...
August 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29018923/is-drug-induced-bone-loss-acceptable-in-premenopausal-women-a-practical-fracture-risk-modeling-exercise
#9
N Binkley, R Besuyen, T Fuerst, L Skillern, D Hans
Premenopausal bone loss increases fracture risk later in life. Depending on peak values, varying degrees of bone mass and microarchitectural loss can be tolerated. We suggest that risk-benefit assessments of drugs that cause premenopausal bone loss be individualized considering baseline status and subsequent BMD and TBS loss. INTRODUCTION: It is logical that drug-induced loss of bone mass and microarchitecture in young adults increase fracture risk later in life. However, no existing data quantify how drug-induced bone loss in younger adults impacts fracture risk later in life...
October 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29017023/maternal-iron-nutriture-as-a-critical-modulator-of-fasd-risk-in-alcohol-exposed-pregnancies
#10
Kaylee K Helfrich, Nipun Saini, Pamela J Kling, Susan M Smith
Alcohol consumption during pregnancy places the fetus at risk for permanent physical, cognitive, and behavioral impairments, collectively termed fetal alcohol spectrum disorders (FASD). However, prenatal alcohol exposure (PAE) outcomes vary widely, and growing evidence suggests that maternal nutrition is a modifying factor. Certain nutrients, such as iron, may modulate FASD outcomes. Untreated gestational iron deficiency (ID) causes persistent neurodevelopmental deficits in the offspring that affect many of the same domains damaged by PAE...
October 10, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29016679/perimenopause-and-emergence-of-an-alzheimer-s-bioenergetic-phenotype-in-brain-and-periphery
#11
Lisa Mosconi, Valentina Berti, Crystal Guyara-Quinn, Pauline McHugh, Gabriella Petrongolo, Ricardo S Osorio, Christopher Connaughty, Alberto Pupi, Shankar Vallabhajosula, Richard S Isaacson, Mony J de Leon, Russell H Swerdlow, Roberta Diaz Brinton
After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The biological mechanisms underlying the increased AD risk in women remain largely undetermined. Preclinical studies identified the perimenopause to menopause transition, a neuroendocrine transition state unique to the female, as a sex-specific risk factor for AD. In animals, estrogenic regulation of cerebral glucose metabolism (CMRglc) falters during perimenopause. This is evident in glucose hypometabolism and decline in mitochondrial efficiency which is sustained thereafter...
2017: PloS One
https://www.readbyqxmd.com/read/28993358/novel-management-of-a-giant-cervical-myoma-in-a-premenopausal-patient
#12
Jolene Wong, Grace Hwei Ching Tan, Ravichandran Nadarajah, Melissa Teo
Cervical myomas are rare and account for <1% of uterine leiomyomas. Clinical complications include bulk-related symptoms of pelvic pain, abnormal bleeding and infertility. While hysterectomies may be readily performed for postmenopausal women; the management of women with cervical myomas of childbearing age remains a challenge.Traditionally described fertility-preserving procedures such as myomectomy, endometrial ablation or myolysis may only be applied to leiomyomas within the uterine corpus. Little is known about the surgical management of its cervical counterpart...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28992246/dietary-protein-intake-and-early-menopause-in-the-nurses-health-study-ii
#13
Maegan E Boutot, Alexandra Purdue-Smithe, Brian W Whitcomb, Kathleen L Szegda, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Elizabeth R Bertone-Johnson
Early menopause, the cessation of ovarian function prior to age 45, affects 5-10% of Western women and is associated with an increased risk of adverse health outcomes. Literature suggests that high vegetable protein intake may prolong female reproductive function. We evaluated the relation of long-term intake of vegetable protein, animal protein, and specific protein-rich foods with incidence of early natural menopause in the Nurses' Health Study II cohort. Women included in analyses (n = 85,682) were premenopausal at baseline (1991) and followed until 2011 for onset of natural menopause...
June 24, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28990664/hormone-receptors-analysis-in-idiopathic-progressive-subglottic-stenosis
#14
Ivana Fiz, Zeid Bittar, Cesare Piazza, Jan Constantin Koelmel, Federico Gatto, Diego Ferone, Francesco Fiz, Diana Di Dio, Alexander Bosse, Giorgio Peretti, Christian Sittel
OBJECTIVE: Idiopathic subglottic stenosis predominantly affects fertile and perimenopausal women. Estrogens and/or progesterone have been proposed as mediators of its pathogenesis by stimulating collagen deposition within the upper airway. We evaluated the presence and expression of estrogen-alpha (ER-α), estrogen-beta (ER-β), and progesterone receptors (PR) in idiopathic stenotic patients. STUDY DESIGN: A retrospective analysis on 42 surgical specimens from idiopathic stenosis female patients (mean age, 52...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28989133/gingival-crevicular-fluid-turnover-markers-in-premenopausal-vs-postmenopausal-women-receiving-orthodontic-treatment
#15
Anusha Bitra, B Jhansi Rani, Sanket S Agarkar, Anuj S Parihar, Gopinath P Vynath, Shekhar Grover
BACKGROUND: Orthodontic treatment is one of the commonly used dental treatments. Orthodontic forces act on the bone by modulating the biomolecules, chiefly the osteoprotegerin (OPG), osteopontin (OPN), receptor activator of nuclear factor kappa-B (RANK), and RANK ligand (RANKL) (OPG ligand). Hormonal changes are known to cause marked alteration in the levels of these biomolecules. Hence, we planned this study to evaluate the response of bone biomarkers in the gingival crevicular fluid (GCF) in postmenopausal women undergoing fixed orthodontic therapy...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28984395/the-cost-of-reproduction-in-women-reproductive-effort-and-oxidative-stress-in-premenopausal-and-postmenopausal-american-women
#16
Anna Ziomkiewicz, Amara Frumkin, Yawei Zhang, Amelia Sancilio, Richard G Bribiescas
OBJECTIVES: Life history theory predicts a trade-off between female investment in reproduction and somatic maintenance, which can result in accelerated senescence. Oxidative stress has been shown to be a causal physiological mechanism for accelerated aging and a possible contributor to this trade-off. We aimed to test the hypothesis for the existence of significant associations between measures of reproductive effort and the level of oxidative stress biomarkers in premenopausal and postmenopausal American women...
October 6, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28984174/the-effect-of-menopause-on-the-relationship-between-hyperlipidemia-and-periodontal-disease-via-salivary-8-hydroxy-2-deoxyguanosine-and-myeloperoxidase-levels
#17
Esra Sinem Kemer Doğan, Fatma Yeşim Kırzıoğlu, Burak Doğan, Özlem Fentoğlu, Banu Kale
OBJECTIVE: Impairment of the lipid metabolism could affect the periodontal disease; increased oxidative stress may have a role in this relationship. The aim of the present study was to evaluate the role of menopause in the relationship between hyperlipidemia and periodontal disease via oxidative stress markers in saliva. MATERIALS AND METHODS: Sixty-seven women were enrolled in the study and divided into four groups as systemically healthy and premenopause (C) (n = 18), hyperlipidemia and premenopause (H) (n = 16), systemically healthy and postmenopause (M) (n = 17), and hyperlipidemia and postmenopause (MH) (n = 16)...
October 6, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28983852/autism-spectrum-disorder-and-li-fraumeni-syndrome-purely-coincidental-or-mechanistically-associated
#18
Michaela Kuhlen, Julia Taeubner, Dagmar Wieczorek, Arndt Borkhardt
BACKGROUND: Autism spectrum disorders (ASDs) are neurodevelopmental disorders with impaired social interactions and communication and restrictive, repetitive patterns of behaviors, interests, and activities. A recent epidemiological study suggests that children with ASD might have an increased cancer risk. CASE PRESENTATION: The 14.5-year-old boy, previously diagnosed with ASD, was referred with persistent bone pain. Diagnostic work-up confirmed diagnosis of acute lymphoblastic leukemia (ALL); cytogenetic analysis revealed low hypodiploid karyotype with a mutation (c...
October 5, 2017: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/28983157/obesity-and-associated-cardiometabolic-risk-among-women-from-tripura-a-northeastern-state-of-india
#19
Purnajita Sen, Sandeep Das, Samrat Hore, Surajit Bhattacharjee, Dipayan Choudhuri
INTRODUCTION: Cardiometabolic health status of women is a serious public health concern. Markers of body fat content and their distribution are important indicators of cardiometabolic health risk in participants. In addition, socio-demographic status plays a determinant role. The aim of the study was to evaluate the influence of adiposity markers and socio-demographic determinants on various cardiovascular and metabolic risk factors in Indian women. MATERIALS AND METHODS: The study was conducted on 388 women (age 25-65 years) from Tripura, a Northeastern state of India...
July 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28983080/biomarkers-of-inflammation-and-breast-cancer-risk-a-case-control-study-nested-in-the-epic-varese-cohort
#20
Claudia Agnoli, Sara Grioni, Valeria Pala, Alessandra Allione, Giuseppe Matullo, Cornelia Di Gaetano, Giovanna Tagliabue, Sabina Sieri, Vittorio Krogh
Breast cancer (BC) is the leading cause of cancer death in women. Adipokines, and other inflammation molecules linked to adiposity, are suspected to be involved in breast carcinogenesis, however prospective findings are inconclusive. In a prospective nested case-control study within the EPIC-Varese cohort, we used conditional logistic regression to estimate rate ratios (RRs) for BC, with 95% confidence intervals (CI), in relation to plasma levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6, leptin, and adiponectin, controlling for BC risk factors...
October 5, 2017: Scientific Reports
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