keyword
https://read.qxmd.com/read/38431780/treatment-and-prognosis-of-male-breast-cancer-a-multicentric-retrospective-study-over-11-years-in-the-czech-republic
#21
JOURNAL ARTICLE
Zuzana Bielcikova, Milos Holanek, Iveta Selingerova, Ondrej Sorejs, Iveta Kolarova, Renata Soumarova, Jan Proks, Lucie Reifova, Vlastimila Cmejlova, Lenka Linkova, Michaela Zabojnikova, Martina Chodacka, Lucie Janovska, Lenka Lisnerova, Karolina Kasparova, Denisa Pohankova, Lubos Petruzelka
PURPOSE: Male breast cancer (MBC) is a rare, but increasingly common disease, and lacks prospective studies. Collaborative efforts are needed to understand and address MBC, including its prognosis, in different countries. METHODS: We retrospectively reviewed the clinical, histopathological, and molecular-genetic characteristics, treatments, and survival outcomes of MBC diagnosed between 2007 and 2017 in the Czech Republic. Prognostic factors of overall survival (OS), recurrence-free interval (RFi), and breast cancer-specific mortality (BCSM) were analyzed and indirectly compared to international data...
March 2, 2024: Oncologist
https://read.qxmd.com/read/38424277/a-multiparametric-mri-based-radiomics-model-for-stratifying-postoperative-recurrence-in-luminal-b-breast-cancer
#22
JOURNAL ARTICLE
Kepei Xu, Meiqi Hua, Ting Mai, Xiaojing Ren, Xiaozheng Fang, Chunjie Wang, Min Ge, Hua Qian, Maosheng Xu, Ruixin Zhang
This study aims to develop an MRI-based radiomics model to assess the likelihood of recurrence in luminal B breast cancer. The study analyzed medical images and clinical data from 244 patients with luminal B breast cancer. Of 244 patients, 35 had experienced recurrence and 209 had not. The patients were randomly divided into the training set (51.5 ± 12.5 years old; n = 171) and the test set (51.7 ± 11.3 years old; n = 73) in a ratio of 7:3...
February 29, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38417630/global-interactome-mapping-reveals-pro-tumorigenic-interactions-of-nf-%C3%AE%C2%BAb-in-breast-cancer
#23
JOURNAL ARTICLE
Petr Lapcik, R Greg Stacey, David Potesil, Petr Kulhanek, Leonard J Foster, Pavel Bouchal
NF-κB pathway is involved in inflammation, however, recent data shows its role also in cancer development and progression, including metastasis. To understand the role of NF-κB interactome dynamics in cancer, we study the complexity of breast cancer interactome in luminal A breast cancer model and its rearrangement associated with NF-κB modulation. Liquid chromatography-mass spectrometry measurement of 160 size exclusion chromatography (SEC) fractions identifies 5460 protein groups. 7568 interactions among these proteins have been reconstructed by PrInCE algorithm, of which 2564 have been validated in independent datasets...
February 26, 2024: Molecular & Cellular Proteomics: MCP
https://read.qxmd.com/read/38416927/pure-mucinous-carcinoma-of-the-breast-radiologic-pathologic-correlation
#24
JOURNAL ARTICLE
Cherie M Kuzmiak, Benjamin C Calhoun
Mucinous carcinoma (MC) of the breast is a rare, specialized subtype of invasive breast carcinoma (IBC) accounting for approximately 1% to 4% of all primary breast malignancies. Mucinous carcinoma occurs predominantly in patients who are postmenopausal or elderly. It is usually detected on screening mammography, but occasionally the patient may present with a palpable mass. The most common mammographic appearance is an equal to high density, oval or round mass with circumscribed or indistinct margins; MC can mimic a benign lesion...
March 20, 2023: Journal of breast imaging
https://read.qxmd.com/read/38416305/effect-of-eccentric-fixation-on-the-steady-state-pattern-electroretinogram
#25
JOURNAL ARTICLE
Evelyn B N Friedel, Julia Haldina, Kathrin Nickel, Michael Bach, Ludger Tebartz van Elst, Sven P Heinrich
PURPOSE: The steady-state pattern electroretinogram (ssPERG) is used to assess retinal ganglion cell function in a variety of research contexts and diagnostic applications. In certain groups of patients or study participants, stable central fixation of the stimulus is not guaranteed. The present study aimed at assessing the effects of misfixation on the ssPERG response to checkerboard reversal stimuli. METHODS: Using two check sizes (0.8° and 15°), we compared ssPERG responses for several amounts of fixation deviation, ranging from 0° to 19° horizontally and from 0° to 14° diagonally...
February 28, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38403109/clinical-sequencing-defines-the-somatic-and-germline-mutation-landscapes-of-chinese-her2-low-breast-cancer
#26
JOURNAL ARTICLE
Bo-Yue Han, Chao Chen, Hong Luo, Cai-Jin Lin, Xiang-Chen Han, Javaria Nasir, Jin-Xiu Shi, Wei Huang, Zhi-Ming Shao, Hong Ling, Xin Hu
More than half of the breast cancer initially labeled as human epidermal growth factor receptor 2 (HER2)-negative actually exhibited low HER2 levels (IHC 1+ or IHC 2+/FISH-) and were classified as HER2-low breast cancer. Previous research emphasized the significant biological heterogeneity in HER2-low breast cancer, highlighting the importance of accurately characterizing HER2-low tumors to promote the precise management of antibody‒drug conjugates. In this study, we established a large-scale targeted sequencing cohort (N = 1907) representing Chinese HER2-low breast cancer patients with detailed clinical annotation...
February 23, 2024: Cancer Letters
https://read.qxmd.com/read/38401854/detection-of-retinal-dysfunction-induced-by-hcn-channel-inhibitors-using-multistep-light-stimulus-and-long-duration-light-stimulus-erg-in-rats
#27
JOURNAL ARTICLE
Naohisa Umeya, Yuki Yoshizawa, Kosuke Fukuda, Keigo Ikeda, Mami Kamada, Hiroshi Inada, Toru Usui, Izuru Miyawaki
Ivabradine, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel inhibitor, has been reported to induce photosensitivity-related visual disturbances such as phosphene in humans. Ivabradine-induced visual disturbances are caused by inhibition of HCN channels in the retina, and the mechanisms have been verified using HCN channel knockout mice and electroretinography (ERG). However, in rats, classical ERG using single flash light stimulus with standard analyses of waveform amplitude and latency has not revealed abnormal retinal function after administration of ivabradine...
February 22, 2024: Experimental Eye Research
https://read.qxmd.com/read/38400758/multi-tissue-transcriptome-wide-association-studies-identified-235-genes-for-intrinsic-subtypes-of-breast-cancer
#28
JOURNAL ARTICLE
James L Li, Julian C McClellan, Haoyu Zhang, Guimin Gao, Dezheng Huo
BACKGROUND: Although genome-wide association studies (GWAS) of breast cancer (BC) identified common variants which differ between intrinsic subtypes, genes through which these variants act to impact BC risk have not been fully established. Transcriptome-wide association studies (TWAS) have identified genes associated with overall BC risk, but subtype-specific differences are largely unknown. METHODS: We performed two multi-tissue TWASs for each BC intrinsic subtype including an expression-based approach that collated TWAS signals from expression quantitative trait loci (eQTLs) across multiple tissues and a novel splicing-based approach that collated signals from splicing QTLs (sQTLs) across intron clusters and subsequently across tissues...
February 23, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38390870/anastrozole-and-tamoxifen-impact-on-igg-glycome-composition-dynamics-in-luminal-a-and-luminal-b-breast-cancers
#29
JOURNAL ARTICLE
Borna Rapčan, Matko Fančović, Tea Pribić, Iva Kirac, Mihaela Gaće, Frano Vučković, Gordan Lauc
This study examines the intricate relationship between protein glycosylation dynamics and therapeutic responses in Luminal A and Luminal B breast cancer subtypes, focusing on anastrozole and tamoxifen impacts. The present methods inadequately monitor and forecast patient reactions to these treatments, leaving individuals vulnerable to the potential adverse effects of these medications. This research investigated glycan structural changes by following patients for up to 9 months. The protocol involved a series of automated steps including IgG isolation, protein denaturation, glycan labelling, purification, and final analysis using capillary gel electrophoresis with laser-induced fluorescence...
February 1, 2024: Antibodies
https://read.qxmd.com/read/38387487/tissue-specific-compensatory-mechanisms-maintain-tissue-architecture-and-body-size-independent-of-cell-size-in-polyploid-zebrafish
#30
JOURNAL ARTICLE
C D Small, T J Benfey, B D Crawford
Genome duplications and ploidy transitions have occurred in nearly every major taxon of eukaryotes, but they are far more common in plants than in animals. Due to the conservation of the nuclear:cytoplasmic volume ratio increased DNA content results in larger cells. In plants, polyploid organisms are larger than diploids as cell number remains relatively constant. Conversely, vertebrate body size does not correlate with cell size and ploidy as vertebrates compensate for increased cell size to maintain tissue architecture and body size...
February 20, 2024: Developmental Biology
https://read.qxmd.com/read/38385473/arterial-involvement-of-lower-limbs-in-peripheral-artery-disease-the-difference-between-diabetics-and-non-diabetics
#31
JOURNAL ARTICLE
Tanzeela Khan, Naheed Khan, Sajida Qureshi
OBJECTIVE: To detect peripheral artery disease in diabetic and non-diabetic individuals. METHODS: The case-control study was conducted from October 2018 to September 2019 at Ruth K.M. Pfau Civil Hospital, Karachi, and comprised diagnosed diabetic patients with random blood sugar ≥200mg/dl in group A, and healthy non-diabetic subjects in group B. Ankle brachial pressure index was measured and mean luminal diameters of lower limb arteries were compared using colour Doppler ultrasonography...
February 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38384489/use-of-the-gene-expression-test-prosigna-%C3%A2-in-premenopausal-patients-with-hr-her2-early-breast-cancer-correlation-of-the-results-with-the-proliferation-marker-ki-67
#32
JOURNAL ARTICLE
Cordula Ziegler, Karl Sotlar, Daniel Maria Hofmann, Thomas Kolben, Nadia Harbeck, Rachel Wuerstlein
INTRODUCTION: In hormone receptor-positive (ER+/PR+) and human epidermal growth factor receptor 2-negative (HER2-) early-stage breast cancer (EBC), gene expression tests such as the Prosigna are increasingly used since classic clinicopathological parameters and the proliferation factor Ki-67 often do not allow a definite therapy decision regarding an adjuvant chemotherapy. While the Prosigna test has been validated for postmenopausal patients, few data are available regarding its use in premenopausal patients...
February 2024: Breast Care
https://read.qxmd.com/read/38380225/breast-cancer-in-young-women-is-it-different-a-single-center-retrospective-cohort-study
#33
JOURNAL ARTICLE
Omalkhair Abulkhair, Ahmad Omair, Dorothy Makanjuola, Manal Al Zaid, Lolwah Al Riyees, Nafisa Abdelhafiez, Emad Masuadi, Ghaida Alamri, Fatinah Althan, Abdulmohsen Alkushi, Ann Partridge
INTRODUCTION: Breast cancer (BC) is one of the commonest cancers among women worldwide. Differences regarding tumor biology, presentation, genetics, and molecular subtypes may contribute to the relatively poorer prognosis among younger women. Limited information exists regarding pathologic characteristics and long-term outcomes among this group. METHODS: This retrospective cohort study included 695 BC patients diagnosed over a 10-year period and investigated the clinicopathological characteristics and long-term disease outcomes among patients diagnosed at age less than or equal to 40 years compared with older ones...
2024: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38378446/proposal-and-practicality-of-an-alternative-blue-light-hazard-risk-assessment-method-for-high-intensity-white-light-sources-at-workplaces
#34
JOURNAL ARTICLE
Stefan Bauer, Maxime Berget, Massimo Borra, Damien Brissinger, Martin Brose, Steffen Görlich, Werner Halbritter, Timo Heepenstrick, Marco Janßen, Emmerich Kitz, Jacek M Kubica, Marta Łowcewicz, Michele Marro, Andrea Militello, Marcin Pelko, Andrzej Rybczyński, Marko Weber, Agnieszka Wolska
Objective . It is prescribed to determine BLH weighted radiances, <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mrow><mml:mi>B</mml:mi></mml:mrow></mml:mrow></mml:msub></mml:math>, for an assessment of spotlights with an angular subtense <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mi>α</mml:mi><mml:mo>≥</mml:mo><mml:mrow><mml:mn>11</mml:mn></mml:mrow><mml:mrow><mml:mi>mrad</mml:mi></mml:mrow></mml:math>...
February 20, 2024: International Journal of Occupational Safety and Ergonomics: JOSE
https://read.qxmd.com/read/38376160/-listeria-adhesion-protein-orchestrates-caveolae-mediated-apical-junctional-remodeling-of-epithelial-barrier-for-listeria-monocytogenes-translocation
#35
JOURNAL ARTICLE
Rishi Drolia, Donald B Bryant, Shivendra Tenguria, Zuri A Jules-Culver, Jessie Thind, Breanna Amelunke, Dongqi Liu, Nicholas L F Gallina, Krishna K Mishra, Manalee Samaddar, Manoj R Sawale, Dharmendra K Mishra, Abigail D Cox, Arun K Bhunia
UNLABELLED: The cellular junctional architecture remodeling by Listeria adhesion protein-heat shock protein 60 (LAP-Hsp60) interaction for Listeria monocytogenes ( Lm ) passage through the epithelial barrier is incompletely understood. Here, using the gerbil model, permissive to internalin (Inl) A/B-mediated pathways like in humans, we demonstrate that Lm crosses the intestinal villi at 48 h post-infection. In contrast, the single isogenic ( lap - or Δ inlA ) or double ( lap - Δ inlA ) mutant strains show significant defects...
March 13, 2024: MBio
https://read.qxmd.com/read/38354833/a-high-black-hole-to-host-mass-ratio-in-a-lensed-agn-in-the-early-universe
#36
JOURNAL ARTICLE
Lukas J Furtak, Ivo Labbé, Adi Zitrin, Jenny E Greene, Pratika Dayal, Iryna Chemerynska, Vasily Kokorev, Tim B Miller, Andy D Goulding, Anna de Graaff, Rachel Bezanson, Gabriel B Brammer, Sam E Cutler, Joel Leja, Richard Pan, Sedona H Price, Bingjie Wang, John R Weaver, Katherine E Whitaker, Hakim Atek, Ákos Bogdán, Stéphane Charlot, Emma Curtis-Lake, Pieter van Dokkum, Ryan Endsley, Robert Feldmann, Yoshinobu Fudamoto, Seiji Fujimoto, Karl Glazebrook, Stéphanie Juneau, Danilo Marchesini, Micheal V Maseda, Erica Nelson, Pascal A Oesch, Adèle Plat, David J Setton, Daniel P Stark, Christina C Williams
Early JWST observations have uncovered a new population of red sources that might represent a previously overlooked phase of supermassive black hole growth1--3 . One of the most intriguing examples is an extremely red, point-like object that was found to be triply-imaged by the strong lensing (SL) cluster Abell 27444 . Here we present deep JWST/NIRSpec observations of this object, Abell2744-QSO1. The spectroscopy confirms that the three images are of the same object, and that it is a highly reddened (AV  ≃ 3) broad emission line Active Galactic Nucleus (AGN) at a redshift of zspec  = 7...
February 14, 2024: Nature
https://read.qxmd.com/read/38349232/fully-printable-and-reconfigurable-hufu-type-electroluminescent-devices-for-visualized-encryption
#37
JOURNAL ARTICLE
Ziqing Luo, Wenfu Chen, Mengnan Lai, Shiyang Shi, Pengyu Chen, Xiaolong Yang, Zhan Chen, Ben Wang, Yaokang Zhang, Xuechang Zhou
Hufu, serving as evidence of imperial authorization in ancient China, comprises two parts in the form of tiger-shaped tallies that only become effective when matched. Drawing inspiration from the concept of Hufu, a reconfigurable electroluminescent (EL) device is designed by separating conventional integral devices into two parts that contain the EL layer (part A) and the transparent electrode (part B), respectively. The key to realizing such strategy is employing an adhesive and stretchable polymer gel composite as the transparent electrodes for the EL devices...
February 13, 2024: Advanced Materials
https://read.qxmd.com/read/38339428/macrophages-promote-subtype-conversion-and-endocrine-resistance-in-breast-cancer
#38
JOURNAL ARTICLE
Xiaoyan Zhang, Fengyu Yang, Zhijian Huang, Xiaojun Liu, Gan Xia, Jieye Huang, Yang Yang, Junchen Li, Jin Huang, Yuxin Liu, Ti Zhou, Weiwei Qi, Guoquan Gao, Xia Yang
BACKGROUND: The progression of tumors from less aggressive subtypes to more aggressive states during metastasis poses challenges for treatment strategies. Previous studies have revealed the molecular subtype conversion between primary and metastatic tumors in breast cancer (BC). However, the subtype conversion during lymph node metastasis (LNM) and the underlying mechanism remains unclear. METHODS: We compared clinical subtypes in paired primary tumors and positive lymph nodes (PLNs) in BC patients and further validated them in the mouse model...
February 5, 2024: Cancers
https://read.qxmd.com/read/38335869/nonvisual-system-mediated-body-color-change-in-fish-reveals-nonvisual-function-of-opsin-3-in-skin
#39
JOURNAL ARTICLE
Zihao Zhang, Chenchen Shi, Jian Han, Xiaoyu Ge, Na Li, Yang Liu, Jing Huang, Shixi Chen
Body-color changes in many poikilothermic animals can occur quickly. This color change is generally initiated by visual system, followed by neuromuscular or neuroendocrine control. We have previously showed that the ventral skin color of the large yellow croaker (Larimichthys crocea) presents golden yellow in dark environment and quickly changes to silvery white in light environment. In the present study, we found that the light-induced whitening of ventral skin color was independent of visual input. Using light-emitting diode sources of different wavelength with same luminance (150 lx) but different absolute irradiance (0...
February 4, 2024: Journal of Photochemistry and Photobiology. B, Biology
https://read.qxmd.com/read/38335419/her2-positive-is-an-independent-indicator-for-predicting-pathological-complete-response-to-neoadjuvant-therapy-and-ki67-changed-after-neoadjuvant-chemotherapy-predicts-favorable-prognosis-in-chinese-women-with-locally-advanced-breast-cancer
#40
JOURNAL ARTICLE
Yutong Fang, Qunchen Zhang, Yuan Wu, Jundong Wu
The growing body of evidence suggests that breast cancer (BC) who achieve pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) may experience a more favorable prognosis. The objective of this study is to investigate the correlation between clinicopathologic parameters of locally advanced breast cancer (LABC) patients and the outcomes of NAC, with the aim of identifying predictive indicators for pCR. Additionally, we seek to examine the conversion of IHC markers in pCR patients following NAC and its impact on the prognosis of BC patients...
February 9, 2024: Medicine (Baltimore)
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