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https://www.readbyqxmd.com/read/28915682/systematic-review-and-meta-analysis-of-the-efficacy-of-breast-conservation-therapy-followed-by-radiotherapy-in-four-breast-cancer-subtypes
#1
Xin-Bin Pan, Rou-Jun Chen, Shi-Ting Huang, Yan-Ming Jiang, Xiao-Dong Zhu
The different molecular subtypes of breast cancer are associated with distinct outcomes. We assessed the efficacy of breast conservation therapy (BCT) followed by radiotherapy for patients with different breast cancer subtypes. We searched the MEDLINE, EMBASE, and Cochrane Library databases to identify studies published prior to April 30, 2016 that assessed the efficacy of BCT followed by radiotherapy in breast cancer patients with different molecular subtypes. A meta-analysis of seven studies that included 3,798 luminal A, 770 luminal B, 344 human epidermal growth factor receptor 2 (Her-2), and 767 triple-negative breast cancer (TNBC) patients was performed...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912475/the-impact-of-young-age-for-prognosis-by-subtype-in-women-with-early-breast-cancer
#2
Weibin Lian, Fangmeng Fu, Yuxiang Lin, Minjun Lu, Boyang Chen, Peidong Yang, Bangwei Zeng, Meng Huang, Chuan Wang
Young age (≤40 years) use to be considered an independent risk factor for the prognosis of women with early-stage breast cancer. We conducted a retrospective analysis to investigate this claim in a population of young patients who were stratified by molecular subtype. We identified 2,125 women with stage I to III breast cancer from the Fujian Medical University Union Hospital. Multivariable Cox proportional hazards models were used to analyze the relationship between age groups stratified by molecular subtype and 5-year disease-free survival (DFS), 5-year distant metastasis-free survival (DMFS), and 5-year breast cancer-specific survival (BCSS)...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911862/fatty-acid-binding-protein-fabp-5-interacts-with-the-calnexin-cytoplasmic-domain-at-the-endoplasmic-reticulum
#3
Joanna Jung, Jessica Wang, Jody Groenendyk, Dukgyu Lee, Marek Michalak, Luis B Agellon
Calnexin is a type 1 integral endoplasmic reticulum membrane molecular chaperone with an endoplasmic reticulum luminal chaperone domain and a highly conserved C-terminal domain oriented to the cytoplasm. Fabp5 is a cytoplasmic protein that binds long-chain fatty acids and other lipophilic ligands. Using a yeast two-hybrid screen, immunoprecipitation, microscale thermophoresis analysis and cellular fractionation, we discovered that Fabp5 interacts with the calnexin cytoplasmic C-tail domain at the endoplasmic reticulum...
September 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28911169/obesity-induced-infertility-in-male-mice-is-associated-with-disruption-of-crisp4-expression-and-sperm-fertilization-capacity
#4
Beatriz C Borges, David Garcia-Galiano, Sanseray da Silveira Cruz-Machado, Xingfa Han, Galina B Gavrilina, Thomas L Saunders, Richard J Auchus, Saher S Hammoud, Gary D Smith, Carol F Elias
Approximately 15% of human couples of reproductive age have impaired fertility, and the male component accounts for about half of these cases. The etiology is usually unknown, but high correlation with the increase in obesity rates is documented. In this study, we show that diet-induced and genetically obese mice display copulatory behavior comparable to controls, but the number of females impregnated by obese males is remarkably low. Screening for changes in gene expression in the male reproductive tract showed decreased Crisp4 expression in testis and epididymis of obese mice...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28903439/lymph-node-status-in-different-molecular-subtype-of-breast-cancer-triple-negative-tumours-are-more-likely-lymph-node-negative
#5
Ning Liu, Zhigang Yang, Xiaozhen Liu, Yun Niu
BACKGROUND AND OBJECTIVES: To investigate the association between different molecular subtype (MST) and the axillary lymph nodal (ALN) status. MATERIALS AND METHODS: A total of 528 female patients with primary breast cancer were collected. Survival estimates were calculated using the Kaplan-Meier method, univariate and multivariate logistic regression models. RESULTS: Triple negative and Luminal A breast cancers were more frequently node-negative (N0) when compared to Luminal B and Her-2 positive cancers (77...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900476/breast-cancer-in-angola-molecular-subtypes-a-first-glance
#6
Fernando Miguel, Lygia Vieira Lopes, Eduardo Ferreira, Emília Ribas, Alexis Fuentes Pelaez, Conceição Leal, Teresina Amaro, Paula Lopes, Cristina Mendes Santos, Carlos Lopes, Lúcio Lara Santos
PURPOSE: The aim of this study was to investigate the breast cancer (BC) molecular subtypes according to its surrogate immunohistochemistry (IHC) markers. We conducted a preliminary study, to correlate the clinical pathological profiles and molecular subtypes of breast cancer in Luanda, Angola. METHODS: From January 2011 to 30 December 2014, 140 consecutive cases of microscopically confirmed invasive breast carcinoma were classified regarding histology and IHC (ER, PR, HER2, and Ki-67)...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28899737/expression-of-yes-associated-protein-yap-and-its-clinical-significance-in-breast-cancer-tissues
#7
Lanqing Cao, Ping-Li Sun, Min Yao, Meng Jia, Hongwen Gao
The transcriptional co-activator YES-associated protein (YAP) has been reported to act as both an oncogene and tumor suppressor in breast cancers. In this study, we evaluated YAP expression immunohistochemically in 324 breast cancer tissues and correlated the expression with clinicopathological findings and patient survival data. Additionally, we reviewed the literature to clarify the role of YAP in breast cancer. We detected YAP, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth receptor-2 (HER2) expression and a Ki67 labeling index >20% in 53...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28898983/ki-67-expression-in-breast-cancer-tissue-microarrays-assessing-tumor-heterogeneity-concordance-with-full-section-and-scoring-methods
#8
Thaer Khoury, Gary Zirpoli, Stephanie M Cohen, Joseph Geradts, Angela Omilian, Warren Davis, Wiam Bshara, Ryan Miller, Michelle M Mathews, Melissa Troester, Julie R Palmer, Christine B Ambrosone
Objectives: Ki-67 has been proposed to be used as a surrogate marker to differentiate luminal breast carcinomas (BCs). The purpose of this study was to determine the utility of and best approaches for using tissue microarrays (TMAs) and Ki-67 staining to distinguish luminal subtypes in large epidemiology studies of luminal/human epidermal growth factor receptor 2 (HER2)-negative BC. Methods: Full-section and TMA (three 0.6-mm cores and two 1.0-mm cores) slides of 109 cases were stained with Ki-67 antibody...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28890304/hemodynamic-parameters-that-may-predict-false-lumen-growth-in-type-b-aortic-dissection-after-endovascular-repair-a-preliminary-study-on-long-term-multiple-follow-ups
#9
Huanming Xu, Zhenfeng Li, Huiwu Dong, Yilun Zhang, Jianyong Wei, Paul N Watton, Wei Guo, Duanduan Chen, Jiang Xiong
Thoracic endovascular aortic repair (TEVAR) is commonly applied in type-B aortic dissection. For patients with dissection affects descending aorta and extends downward to involve abdominal aorta and possibly iliac arteries, false lumen (FL) expansion might occur post-TEVAR. Predictions of dissection development may assist in medical decision on re-intervention or surgery. In this study, two patients are selected with similar morphological features at initial presentation but with different long-term FL development post-TEVAR (stable and enlarged FL)...
September 7, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28887760/sialadenoma-papilliferum-analysis-of-seven-new-cases-and-review-of-the-literature
#10
Craig B Fowler, Douglas D Damm
Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm that comprises from 0.4 to 1.2% of all salivary gland tumors. The tumor is so named because of its microscopic resemblance to the syringocystadenoma papilliferum, an uncommon benign tumor of sweat gland origin. The purpose of this paper is to report the clinical and microscopic features of seven new cases of SP and combine them with cases previously reported in the English language literature to further define this unusual lesion. Combining our cases with acceptable cases from the literature, the palate (especially the hard palate) was the most common site, with 80% of the cases occurring in this location...
September 8, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28886748/erbb3-drives-mammary-epithelial-survival-and-differentiation-during-pregnancy-and-lactation
#11
Michelle M Williams, David B Vaught, Meghan Morrison Joly, Donna J Hicks, Violeta Sanchez, Philip Owens, Bushra Rahman, David L Elion, Justin M Balko, Rebecca S Cook
BACKGROUND: During pregnancy, as the mammary gland prepares for synthesis and delivery of milk to newborns, a luminal mammary epithelial cell (MEC) subpopulation proliferates rapidly in response to systemic hormonal cues that activate STAT5A. While the receptor tyrosine kinase ErbB4 is required for STAT5A activation in MECs during pregnancy, it is unclear how ErbB3, a heterodimeric partner of ErbB4 and activator of phosphatidyl inositol-3 kinase (PI3K) signaling, contributes to lactogenic expansion of the mammary gland...
September 8, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28886403/increased-mapk1-3-phosphorylation-in-luminal-breast-cancer-related-with-pik3ca-hotspot-mutations-and-prognosis
#12
Diana Ramirez-Ardila, A Mieke Timmermans, Jean A Helmijr, John W M Martens, Els M J J Berns, Maurice P H M Jansen
INTRODUCTION: While mutations in PIK3CA are most frequently (45%) detected in luminal breast cancer, downstream PI3K/AKT/mTOR pathway activation is predominantly observed in the basal subtype. The aim was to identify proteins activated in PIK3CA mutated luminal breast cancer and the clinical relevance of such a protein in breast cancer patients. MATERIALS AND METHODS: Expression levels of 171 signaling pathway (phospho-)proteins established by The Cancer Genome Atlas (TCGA) using reverse phase protein arrays (RPPA) were in silico examined in 361 breast cancers for their relation with PIK3CA status...
September 5, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28884749/comprehensive-clinical-and-molecular-analyses-of-neuroendocrine-carcinomas-of-the-breast
#13
Marion Lavigne, Emmanuelle Menet, Jean-Christophe Tille, Marick Lae, Laetitia Fuhrmann, Claire Bonneau, Gabrielle Deniziaut, Samia Melaabi, Charlotte C K Ng, Caterina Marchiò, Roman Rouzier, Ivan Bièche, Anne Vincent-Salomon
Neuroendocrine breast carcinomas represent a rare subtype of breast cancer. Their definition, prevalence, and prognosis remain controversial in the literature. The 2012 WHO classification of breast cancer categorizes neuroendocrine carcinomas into three morphologically distinct subtypes: well-differentiated neuroendocrine tumors, poorly differentiated neuroendocrine carcinomas, and invasive breast carcinomas with neuroendocrine differentiation. We aimed to gain insight into the clinical, morphologic, phenotypic, and molecular features of 47 neuroendocrine breast carcinomas...
September 8, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28882485/zinc-chloride-rapidly-stimulates-efflux-transporters-in-renal-proximal-tubules-of-killifish-fundulus-heteroclitus
#14
Alexander Zaremba, David S Miller, Gert Fricker
Multidrug resistance-related protein 2 (Mrp2) is an ATP-driven efflux pump at the luminal membrane in renal proximal tubules. It acts as detoxification mechanism by transporting xenobiotics and metabolic products into urine. The trace element zinc is essential for cellular growth, differentiation and survival. It modulates immune response and is used as dietary supplement. Here, we found that 0.1-10μM ZnCl2 rapidly stimulated transport of the Mrp2 probe substrate Texas Red (TR) in isolated killifish renal proximal tubules, which provide an established model system to measure efflux transporter activity by using fluorescent probe substrates, confocal microscopy and image analysis...
September 4, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28881673/bromodomain-inhibition-shows-antitumoral-activity-in-mice-and-human-luminal-breast-cancer
#15
Montserrat Pérez-Salvia, Laia Simó-Riudalbas, Pere Llinàs-Arias, Laura Roa, Fernando Setien, Marta Soler, Manuel Castro de Moura, James E Bradner, Eva Gonzalez-Suarez, Catia Moutinho, Manel Esteller
BET bromodomain inhibitors, which have an antitumoral effect against various solid cancer tumor types, have not been studied in detail in luminal breast cancer, despite the prevalence of this subtype of mammary malignancy. Here we demonstrate that the BET bromodomain inhibitor JQ1 exerts growth-inhibitory activity in human luminal breast cancer cell lines associated with a depletion of the C-MYC oncogene, but does not alter the expression levels of the BRD4 bromodomain protein. Interestingly, expression microarray analyses indicate that, upon JQ1 administration, the antitumoral phenotype also involves downregulation of relevant breast cancer oncogenes such as the Breast Carcinoma-Amplified Sequence 1 (BCAS1) and the PDZ Domain-Containing 1 (PDZK1)...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877889/alcohol-physical-activity-smoking-and-breast-cancer-subtypes-in-a-large-nested-case-control-study-from-the-norwegian-breast-cancer-screening-program
#16
Merete Ellingjord-Dale, Linda Vos, Kirsti Vik Hjerkind, Anette Hjartåker, Hege G Russnes, Steinar Tretli, Solveig Hofvind, Isabel Dos-Santos-Silva, Giske Ursin
BACKGROUND: To what extent alcohol, smoking and physical activity are associated with the various subtypes of breast cancer is not clear. We took advantage of a large population-based screening cohort to determine whether these risk factors also increase the risk of the poor prognosis subtypes. METHODS: We conducted a matched case-control study nested within the Norwegian Breast Cancer Screening Program during 2006-2014. A total of 4 402 breast cancer cases with risk factor and receptor data were identified...
September 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28877888/a-novel-18-marker-panel-predicting-clinical-outcome-in-breast-cancer
#17
Jana Biermann, Szilárd Nemes, Toshima Z Parris, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Gunnar Steineck, Per Karlsson, Khalil Helou
BACKGROUND: Gene expression profiling has made considerable contributions to our understanding of cancer biology and clinical care. This study describes a novel gene expression signature for breast cancer-specific survival that was validated using external datasets. METHODS: Gene expression signatures for invasive breast carcinomas (mainly Luminal B subtype) corresponding to 136 patients were analysed using Cox regression and the effect of each gene on disease-specific survival (DSS) was estimated...
September 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28876589/reconstruction-in-locally-advance-breast-cancer-who-what-and-when
#18
L Van Schalkwyk, C Benn, K Bergstrom
BACKGROUND: Locally advanced breast cancer (LABC) is defined as the most advanced stage of non-metastatic breast cancer. While breast reconstruction is not contraindicated in this subset of patients, the decision-making process is influenced by several considerations, including recurrence risk and the need for and timing of adjuvant therapy such as radiotherapy. This retrospective analysis investigates the reconstructive procedures performed on women presenting with locally advanced breast cancer at the Netcare Breast Care Centre (NCBC) in Johannesburg...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876586/is-ki67-predictive-of-tumour-response-to-neoadjuvant-chemotherapy-and-to-long-term-disease-outcome-in-breast-cancer-patients-at-dr-george-mukhari-academic-hospital-a-preliminary-report
#19
D Mokone, B Ratlabala, M Z Koto, J H R Becker, M Bida
BACKGROUND: The difference in tumour response to neoadjuvant chemotherapy has been attributed to difference in tumour biology. Ki67, a proliferative protein, is one of the molecular markers that are used to predict tumour response to chemotherapy. A high Ki67 index and or a decrease in Ki67 index after a short-term of NAC is said to predict clinical and pathological response and thus disease free survival but not over-all survival. METHOD: A prospective study. Core needle biopsy is repeated after 2 cycles of NAC (8 weeks) in Stage IIb and Stage III breast cancer patients and is compared to base-line biopsy...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28872717/role-of-the-bridging-group-in-bis-pyridyl-ligands-enhancing-both-photo-and-electro-luminescent-features-of-cationic-ipr-cu-i-complexes
#20
Margaux Elie, Michael D Weber, Florent Di Meo, Fabien Sguerra, Jean-François Lohier, Robert B Pansu, Jean-Luc Renaud, Matthieu Hamel, Mathieu Linares, Rubén D Costa, Sylvain Gaillard
We report on the benefits of changing the bridging group X of bis-pyridyl ligands - i.e., Py-X-Py where X is NH, CH2, C(CH3)2 and PPh - on the photo- and electro-luminescent properties of a new family of luminescent cationic NHC copper(I) complexes (NHC : N-Heterocyclic Carbene). A joint experimental and theoretical study demonstrates that the bridging group rules the molecular conformation from a planar-like structure (X is NH and CH2) to a boat-like structure (X is C(CH3)2 and PPh), leading to i) 4-fold enhancement of the photoluminescence quantum yield (φem) without affecting the thermally activated delayed fluorescence mechanism, and ii) one order of magnitude reduction of the ionic conductivity (σ) of thin films...
September 5, 2017: Chemistry: a European Journal
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