keyword
https://read.qxmd.com/read/38492997/a-molecular-typing-method-for-invasive-breast-cancer-by-serum-raman-spectroscopy
#1
JOURNAL ARTICLE
Jun Jiang, Lintao Li, Gang Yin, Huaichao Luo, Junjie Li
BACKGROUND: The incidence of breast cancer ranks highest among cancers and is exceedingly heterogeneous. Immunohistochemical staining is commonly used clinically to identify the molecular subtype for subsequent treatment and prognosis. PURPOSE: Raman spectroscopy and support vector machine (SVM) learning algorithm were utilized to identify blood samples from breast cancer patients in order to investigate a novel molecular typing approach. METHOD: Tumor tissue coarse needle aspiration biopsy samples, and peripheral venous blood samples were gathered from 459 invasive breast cancer patients admitted to the breast department of Sichuan Cancer Hospital between June 2021 and September 2022...
February 16, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38487727/contrast-enhanced-ultrasound-for-the-preoperative-prediction-of-pathological-characteristics-in-breast-cancer
#2
JOURNAL ARTICLE
Ling-Ling Li, Quan-Li Su, Yun-Xia Deng, Wen-Wen Guo, Hai-Mei Lun, Qiao Hu
OBJECTIVE: We aimed to investigate the value of contrast-enhanced ultrasound (CEUS) in the preoperative prediction of the histological grades and molecular subtypes of breast cancer. METHODS: A total of 183 patients with pathologically confirmed breast cancer were included. Contrast enhancement patterns and quantitative parameters were compared in different groups. The receiver operating characteristic (ROC) curve was used to analyze the efficacy of CEUS in the preoperative prediction of pathological characteristics, including histologic grade and molecular subtypes...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38485276/-68-ga-fapi-pet-ct-as-an-alternative-to-18-f-fdg-pet-ct-in-the-imaging-of-invasive-lobular-breast-carcinoma
#3
JOURNAL ARTICLE
Ertan Sahin, Tulay Kus, Alper Aytekin, Evren Uzun, Umut Elboga, Latif Yilmaz, Yusuf B Cayirli, Merve Okuyan, Vuslat Cimen, Ufuk Cimen
Accurate staging of invasive lobular carcinoma (ILC), a subtype of breast cancer, is vital for effective clinical management. Although 18 F-FDG PET/CT is a commonly used tool, its efficacy varies across different histologic subtypes. To mitigate this challenge, our investigation delves into the potential utility of 68 Ga-fibroblast activation protein inhibitor (FAPI) PET/CT as an alternative for staging ILC, aiming to address a significant research gap using a more expansive patient cohort than the smaller samples commonly found in the existing literature...
March 14, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38484209/comprehensive-analysis-identifies-variability-in-pi3k-pathway-alterations-in-triple-negative-breast-cancer-subtypes
#4
JOURNAL ARTICLE
Reva K Basho, Li Zhao, Jason B White, Lei Huo, Roland L Bassett, Elizabeth A Mittendorf, Alastair Thompson, Jennifer K Litton, Naoto Ueno, Banu Arun, Bora Lim, Vicente Valero, Debu Tripathy, Jianhua Zhang, Beatriz E Adrada, Lumarie Santiago, Elizabeth Ravenberg, Sahil Seth, Clinton Yam, Stacy L Moulder, Senthil Damodaran
PURPOSE: The PI3K pathway is frequently altered in triple-negative breast cancer (TNBC). Limited cell line and human data suggest that TNBC tumors characterized as mesenchymal (M) and luminal androgen receptor (LAR) subtypes have increased incidence of alterations in the PI3K pathway. The impact of PI3K pathway alterations across TNBC subtypes is poorly understood. METHODS: Pretreatment tumor was evaluated from operable TNBC patients enrolled on a clinical trial of neoadjuvant therapy (NAT; A Robust TNBC Evaluation fraMework to Improve Survival [ClinicalTrials...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38479682/a-dual-mode-biosensor-based-on-silica-inverse-opal-photonic-crystals-modulated-electrochemiluminescence-and-dye-displacement-colorimetry-for-the-sensitive-detection-of-synthetic-cathinone-in-water-environment
#5
JOURNAL ARTICLE
Meihua Dong, Ding Jiang, Wenchang Wang, Hiroshi Shiigi, Xiaohui Chen, Zhidong Chen
To address the challenges posed by signal capacity limitations and the reliance of sensing methods on single analytical information, this study developed an electrochemiluminescence (ECL) and colorimetric dual-mode sensing platform for the precise detection of 4-chloroethcathinone (4-CEC) in water environments. Firstly, the accurate alignment of the reflection wavelength of appropriately sized silica inverse opal photonic crystals (SIOPCs) with the ECL emission wavelength of luminescent metal-organic frameworks (PCN-224) has been achieved via diameter modulation...
March 11, 2024: Chemosphere
https://read.qxmd.com/read/38477161/b-flow-spatiotemporal-image-correlation-m-mode-ultrasound-provides-novel-method-to-quantify-spiral-artery-remodeling-during-normal-human-pregnancy
#6
JOURNAL ARTICLE
O M Turan, Y Liang, B Kelley, S Turan, G J Pepe, E D Albrecht
OBJECTIVES: During human pregnancy placental extravillous trophoblasts replace the vascular smooth muscle and elastic tissue within the walls of the uterine spiral arteries, thereby remodeling these arteries into distensible low resistance vessels to promote placental perfusion. The present study, determined whether B-flow/ spatio-temporal image correlation (STIC) M-mode ultrasonography provides an in vivo imaging method to digitally quantify spiral artery luminal distensibility, as a physiological index of spiral artery remodeling, during advancing stages of normal human pregnancy...
March 13, 2024: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38473874/clinical-relevance-of-tumour-infiltrating-immune-cells-in-her2-negative-breast-cancer-treated-with-neoadjuvant-therapy
#7
JOURNAL ARTICLE
Cristina Arqueros, Alberto Gallardo, Silvia Vidal, Rubén Osuna-Gómez, Ariadna Tibau, Olga Lidia Bell, Teresa Ramón Y Cajal, Enrique Lerma, Bárbara Lobato-Delgado, Juliana Salazar, Agustí Barnadas
Currently, therapy response cannot be accurately predicted in HER2-negative breast cancer (BC). Measuring stromal tumour-infiltrating lymphocytes (sTILs) and mediators of the tumour microenvironment and characterizing tumour-infiltrating immune cells (TIICs) may improve treatment response in the neoadjuvant setting. Tumour tissue and peripheral blood samples were retrospectively collected from 118 patients, and sTILs were evaluated. Circulating exosomes and myeloid-derived suppressor cells were determined by flow cytometry...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472594/aging-accumulated-methylmalonic-acid-serum-levels-at-breast-cancer-diagnosis-are-not-associated-with-distant-metastases
#8
JOURNAL ARTICLE
Qi Wu, Sigrid Hatse, Cindy Kenis, Juan Fernández-García, Patricia Altea-Manzano, Jaak Billen, Mélanie Planque, Anke Vandekeere, Yentl Lambrechts, François Richard, Kevin Punie, Patrick Neven, Ann Smeets, Ines Nevelsteen, Giuseppe Floris, Christine Desmedt, Ana P Gomes, Sarah-Maria Fendt, Hans Wildiers
PURPOSE: Recent evidence suggests that age-accumulated methylmalonic acid (MMA) promotes breast cancer progression in mice. This study aims to investigate the association between baseline serum MMA concentrations in patients with breast cancer and the development of subsequent distant metastases. METHODS: We included 32 patients with early Luminal B-like breast cancer (LumB, median age 62.4y) and 52 patients with early triple-negative breast cancer (TNBC, median age 50...
March 13, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38465486/-aortic-remodeling-in-uncomplicated-stanford-type-b-aortic-dissection-stratified-by-the-timing-of-thoracic-endovascular-aortic-repair-a-retrospective-cohort-study
#9
JOURNAL ARTICLE
Ikumi Osawa, Yasutoshi Tsuda, Atomu Hino, Takahito Yokoyama, Masato Nakajima
PURPOSE: We investigated the relationship between aortic remodeling and timing of thoracic endovascular aortic repair( TEVAR) in patients with uncomplicated Stanford type B aortic dissection. METHODS: 29 patients with sub-acute and early chronic uncomplicated Stanford type B aortic dissection underwent TEVAR between February 2019 and August 2022 in our hospital. We retrospectively compared aortic remodeling between 19 patients in the sub-acute( SA) group( 15-90 days from onset) and 10 patients in the early chronic( ECh) group( 91-365 days from onset) using the false luminal area reduction rate using computed tomography imagings...
March 2024: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/38454634/age-specific-differences-in-tumour-characteristics-between-screen-detected-and-non-screen-detected-breast-cancers-in-women-aged-40-74-at-diagnosis-in-sweden-from-2008-to-2017
#10
JOURNAL ARTICLE
Håkan Jonsson, Anne Andersson, Zheng Mao, Lennarth Nyström
OBJECTIVE: To analyze differences between screen-detected and non-screen-detected invasive breast cancers by tumour characteristics and age at diagnosis in the nationwide population-based mammography screening program in Sweden. METHODS: Data were retrieved from the National Quality Register for Breast Cancer for 2008-2017. Logistic regression analysis was used to estimate the likelihood for a tumour to be screen-detected by tumour characteristics and age group at diagnosis...
March 7, 2024: Journal of Medical Screening
https://read.qxmd.com/read/38453756/targeting-triple-negative-breast-cancer-stem-cells-using-nanocarriers
#11
REVIEW
Nagasen Dasari, Girija Sankar Guntuku, Sai Kiran S S Pindiprolu
Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, and treatment responses. Categorization of subtypes is based on the presence or absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), leading to subtypes such as luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC). TNBC, comprising around 20% of all breast cancers, lacks expression of ER, PR, and HER2 receptors, rendering it unresponsive to targeted therapies and presenting significant challenges in treatment...
March 7, 2024: Discov Nano
https://read.qxmd.com/read/38452311/b-cell-mediated-immunity-predicts-survival-of-patients-with-estrogen-receptor-positive-breast-cancer
#12
JOURNAL ARTICLE
Seungbok Lee, Byung-Hee Kang, Han-Byoel Lee, Bum-Sup Jang, Wonshik Han, In Ah Kim
PURPOSE: The estrogen receptor-positive (ER+) breast cancer (BC), which constitutes the majority of BC cases, exhibits highly heterogeneous clinical behavior. To aid precision treatments, we aimed to find molecular subtypes of ER+ BC representing the tumor microenvironment and prognosis. METHODS: We analyzed RNA-seq data of 113 patients with BC and classified them according to the PAM50 intrinsic subtypes using gene expression profiles. Among them, we further focused on 44 patients with luminal-type (ER+) BC for subclassification...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38452304/cost-effectiveness-analysis-of-denosumab-in-the-prevention-of-skeletal-related-events-among-patients-with-breast-cancer-with-bone-metastasis-in-india
#13
JOURNAL ARTICLE
Raina Wadhwa, Nidhi Gupta, Jyoti Dixit, Pankaj Malhotra, Pvm Lakshmi, Shankar Prinja
PURPOSE: Denosumab is clinically superior to zoledronic acid (ZA) for preventing and delaying time to first and subsequent skeletal-related events (SREs) among patients with breast cancer (BC) with bone metastases. We evaluated the cost and health benefits of denosumab and ZA (once every 4 weeks and once every 12 weeks) among four different molecular subtypes of BC with bone metastases in India. MATERIALS AND METHODS: A Markov model was developed in Microsoft Excel to estimate lifetime health consequences and resulting costs among cohort of 1,000 patients with BC with bone metastasis, for three intervention scenarios, namely denosumab (once every 4 weeks), ZA (once every 4 weeks), and ZA (once every 12 weeks)...
March 2024: JCO global oncology
https://read.qxmd.com/read/38452040/ai-luminating-artificial-intelligence-in-inflammatory-bowel-diseases-a-narrative-review-on-the-role-of-ai-in-endoscopy-histology-and-imaging-for-ibd
#14
JOURNAL ARTICLE
Phillip Gu, Oreen Mendonca, Dan Carter, Shishir Dube, Paul Wang, Xiuzhen Huang, Debiao Li, Jason H Moore, Dermot P B McGovern
Endoscopy, histology, and cross-sectional imaging serve as fundamental pillars in the detection, monitoring, and prognostication of inflammatory bowel disease (IBD). However, interpretation of these studies often relies on subjective human judgment, which can lead to delays, intra- and interobserver variability, and potential diagnostic discrepancies. With the rising incidence of IBD globally coupled with the exponential digitization of these data, there is a growing demand for innovative approaches to streamline diagnosis and elevate clinical decision-making...
March 7, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38448600/cell-cycle-inhibition-and-immune-microenvironment-in-breast-cancer-treated-with-ribociclib-and-letrozole-or-chemotherapy
#15
JOURNAL ARTICLE
Tomás Pascual, Aranzazu Fernandez-Martinez, Yash Agrawal, Adam D Pfefferle, Nuria Chic, Fara Brasó-Maristany, Blanca Gonzàlez-Farré, Laia Paré, Guillermo Villacampa, Cristina Saura, Cristina Hernando, Montserrat Muñoz, Patricia Galván, Xavier Gonzàlez-Farré, Mafalda Oliveira, Miguel Gil-Gil, Eva Ciruelos, Patricia Villagrasa, Joaquín Gavilá, Aleix Prat, Charles M Perou
In this study, we performed genomic analyses of cell cycle and tumor microenvironment changes during and after ribociclib and letrozole or chemotherapy in the CORALLEEN trial. 106 women with untreated PAM50-defined Luminal B early breast cancers were randomly assigned to receive neoadjuvant ribociclib and letrozole or standard-of-care chemotherapy. Ki67 immunohistochemistry, tumor-infiltrating lymphocytes quantification, and RNA sequencing were obtained from tissue biopsies pre-treatment, on day 14 of treatment, and tumor specimens from surgical resection...
March 6, 2024: NPJ Breast Cancer
https://read.qxmd.com/read/38446366/immunohistochemical-and-molecular-evaluation-of-tusc2-expression-in-breast-cancer
#16
JOURNAL ARTICLE
Leyla Tekin, Tuba Edgünlü, Deniz Genç
OBJECTIVE: Tumor suppressor candidate 2 has shown to be deleted in lung, colon, and bladder cancer types. In the present study, we aimed to investigate the expression of TUSC2 in breast cancer. MATERIALS AND METHODS: A total of thirty patients with breast cancer were included in the study. Normal and tumor tissue samples from fresh mastectomy materials were stored at -80 C until the number of cases was completed for gene expression analysis. Histopathological examination was carried out with routine hematoxylin & eosin method...
March 6, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38443227/bcar4-expression-as-a-predictive-biomarker-for-endocrine-therapy-resistance-in-breast-cancer
#17
JOURNAL ARTICLE
Muheng Liao, Jace Webster, Emily M Coonrod, Katherine N Weilbaecher, Christopher A Maher, Nicole M White
BACKGROUND: Breast cancer, particularly the estrogen receptor positive (ER+) subtype, remains a leading cause of cancer-related death among women. Endocrine therapy is the most effective treatment for ER+ breast cancer; however, the development of resistance presents a significant challenge. This study explored the role of the breast cancer antiestrogen resistance 4 (BCAR4) gene as a potential driver of resistance and a pivotal biomarker in breast cancer. PATIENTS AND METHODS: The researchers undertook a comprehensive analysis of 1743 patients spanning 6 independent cohorts...
February 16, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38439579/iga-mediated-control-of-host-microbial-interaction-during-weaning-reaction-influences-gut-inflammation
#18
JOURNAL ARTICLE
Wenjie Tang, Yusen Wei, Zhixiang Ni, Kangwei Hou, Xin M Luo, Haifeng Wang
The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138 + plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between Bacteroides uniformis ( B. uniformis ) and the host during the weaning period. The IgA-skewed response of CD138 + PCs is essential for B. uniformis to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, B. uniformis within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets...
2024: Gut Microbes
https://read.qxmd.com/read/38438630/balloon-neck-plasty-to-create-a-wide-necked-aneurysm-in-the-elastase-induced-rabbit-model
#19
JOURNAL ARTICLE
Dong-Sung Won, Ki Baek Lee, Jung-Hoon Park, Chu Hui Zeng, Mi Hyeon Kim, Deok Hee Lee
PURPOSE: The elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck size remains challenging. In this study, the technical feasibility and safety of balloon neck-plasty to create a wide-necked aneurysm in rabbit EIA model were investigated. METHODS: Male New Zealand White rabbits (N = 15) were randomly assigned to three groups: group A, EIA creation without neck-plasty; group B, neck-plasty immediately after EIA creation; group C, neck-plasty 4 weeks after EIA creation...
March 4, 2024: Neuroradiology
https://read.qxmd.com/read/38433215/the-proteome-of-the-blood-brain-barrier-in-rat-and-mouse-highly-specific-identification-of-proteins-on-the-luminal-surface-of-brain-microvessels-by-in-vivo-glycocapture
#20
JOURNAL ARTICLE
Tammy-Lynn Tremblay, Wael Alata, Jacqueline Slinn, Ewa Baumann, Christie E Delaney, Maria Moreno, Arsalan S Haqqani, Danica B Stanimirovic, Jennifer J Hill
BACKGROUND: The active transport of molecules into the brain from blood is regulated by receptors, transporters, and other cell surface proteins that are present on the luminal surface of endothelial cells at the blood-brain barrier (BBB). However, proteomic profiling of proteins present on the luminal endothelial cell surface of the BBB has proven challenging due to difficulty in labelling these proteins in a way that allows efficient purification of these relatively low abundance cell surface proteins...
March 4, 2024: Fluids and Barriers of the CNS
keyword
keyword
13420
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.