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https://www.readbyqxmd.com/read/28809778/reprimo-a-potential-p53-dependent-tumor-suppressor-gene-is-frequently-hypermethylated-in-estrogen-receptor-%C3%AE-positive-breast-cancer
#1
Kurt Buchegger, Ismael Riquelme, Tamara Viscarra, Carmen Ili, Priscilla Brebi, Tim Hui-Ming Huang, Juan Carlos Roa
Aberrant DNA methylation is a hallmark of many cancers. Currently, there are four intrinsic molecular subtypes in breast cancer (BC): Luminal A, B, Her2-positive, and triple negative (TNBC). Recently, The Cancer Genome Atlas (TCGA) project has revealed that Luminal subtypes have higher levels of genome-wide methylation that may be a result of Estrogen/Estrogen receptor α (E2/ERα) signaling pathway activation. In this study, we analyze promoter CpG-island (CGIs) of the Reprimo (RPRM) gene in breast cancers (n = 77), cell lines (n = 38), and normal breast tissue (n = 10) using a MBDCap-seq database...
August 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28808804/identification-of-a-new-liver-specific-c-type-mrna-transcriptional-variant-for-mouse-st3gal5-gm3-gm4-synthase
#2
Fumi Shishido, Satoshi Uemura, Takahiro Nitta, Jin-Ichi Inokuchi
GM3, a major lipid component of the plasma membrane outer leaflet in mammalian cells, is synthesized in the luminal side of Golgi by ST3GAL5 protein (ST3G5), a type II membrane protein. Two strains of St3Gal5 knockout mice have been established for studies of GM3 physiological function: St3Gal5-Ex5-KO (lacking exon 5, which contains the catalytic domain of ST3G5), and St3Gal5-Ex3-KO (lacking exon 3, which contains the initiation codons). Results of the present study demonstrate that GM3 synthesis is still present, at a low level, in liver of St3Gal5-Ex3-KO mice...
August 14, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28801774/bcl-2-antigen-expression-in-luminal-a-and-triple-negative-breast-cancer
#3
Carla Solange Escórcio-Dourado, Luana Mota Martins, Camila Maria Simplício-Revoredo, Fabiane Araújo Sampaio, Cléciton Braga Tavares, João Paulo da Silva-Sampaio, Umbelina Soares Borges, Francisco Adelton Alves-Ribeiro, Pedro Vitor Lopes-Costa, José Charles Lima-Dourado, Benedito Borges da Silva
Biomarkers for the prognosis of breast cancer have been routinely used in clinical practice, including the expression of hormone receptors, Ki-67 and HER-2. More recently, Bcl-2 has been recognized as an important prognostic factor in breast cancer, although controversies persist with respect to the significance of its expression. The aim of the present study was to evaluate Bcl-2 antigen expression in luminal A and triple-negative breast cancer. Sixty women with invasive ductal carcinoma were included in the study and divided into two groups: Group A (luminal A) and Group B (triple-negative), with 30 cases in each group...
August 11, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28798279/the-role-of-luminal-ca-regulation-in-ca-signaling-refractoriness-and-cardiac-arrhythmogenesis
#4
REVIEW
Sándor Györke, Andriy E Belevych, Bin Liu, Igor V Kubasov, Cynthia A Carnes, Przemysław B Radwański
No abstract text is available yet for this article.
August 10, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28798125/microbiota-activated-ppar-%C3%AE-signaling-inhibits-dysbiotic-enterobacteriaceae-expansion
#5
Mariana X Byndloss, Erin E Olsan, Fabian Rivera-Chávez, Connor R Tiffany, Stephanie A Cevallos, Kristen L Lokken, Teresa P Torres, Austin J Byndloss, Franziska Faber, Yandong Gao, Yael Litvak, Christopher A Lopez, Gege Xu, Eleonora Napoli, Cecilia Giulivi, Renée M Tsolis, Alexander Revzin, Carlito B Lebrilla, Andreas J Bäumler
Perturbation of the gut-associated microbial community may underlie many human illnesses, but the mechanisms that maintain homeostasis are poorly understood. We found that the depletion of butyrate-producing microbes by antibiotic treatment reduced epithelial signaling through the intracellular butyrate sensor peroxisome proliferator-activated receptor γ (PPAR-γ). Nitrate levels increased in the colonic lumen because epithelial expression of Nos2, the gene encoding inducible nitric oxide synthase, was elevated in the absence of PPAR-γ signaling...
August 11, 2017: Science
https://www.readbyqxmd.com/read/28797035/protein-expression-patterns-of-cell-cycle-regulators-in-operable-breast-cancer
#6
Flora Zagouri, Vassiliki Kotoula, George Kouvatseas, Maria Sotiropoulou, Triantafyllia Koletsa, Theofani Gavressea, Christos Valavanis, Helen Trihia, Mattheos Bobos, Georgios Lazaridis, Angelos Koutras, George Pentheroudakis, Pantelis Skarlos, Dimitrios Bafaloukos, Niki Arnogiannaki, Sofia Chrisafi, Christos Christodoulou, Pavlos Papakostas, Gerasimos Aravantinos, Paris Kosmidis, Charisios Karanikiotis, George Zografos, Christos Papadimitriou, George Fountzilas
BACKGROUND-AIM: To evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, cyclin E1, p21, p27 and p53 in the context of various breast cancer subtypes. METHODS: Cyclin E1, cyclin D1, p53, p21 and p27 were evaluated with immunohistochemistry in 1077 formalin-fixed paraffin-embedded tissues from breast cancer patients who had been treated within clinical trials. Jaccard distances were computed for the markers and the resulted matrix was used for conducting unsupervised hierarchical clustering, in order to identify distinct groups correlating with prognosis...
2017: PloS One
https://www.readbyqxmd.com/read/28796549/association-of-brca-mutation-types-imaging-features-and-pathologic-findings-in-patients-with-breast-cancer-with-brca1-and-brca2-mutations
#7
Su Min Ha, Eun Young Chae, Joo Hee Cha, Hak Hee Kim, Hee Jung Shin, Woo Jung Choi
OBJECTIVE: The purpose of this study is to retrospectively evaluate the relationships between the BRCA mutation types, imaging features, and pathologic findings of breast cancers in BRCA1 and BRCA2 mutation carriers. MATERIALS AND METHODS: We identified patients with breast cancer with BRCA gene mutations from January 2000 to December 2014. After excluding patients who underwent lesion excision before MRI, 99 BRCA1 and 103 BRCA2 lesions in 187 women (mean age, 39...
August 10, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28795861/lnc00673-errlr01-is-a-prognostic-indicator-of-overall-survival-in-breast-cancer
#8
Ubaidat Abdul-Rahman, Balázs Gyoörffy, Brian D Adams
LncRNAs are novel noncoding RNAs involved in the epigenetic regulation of gene expression by recruiting ribonucleoprotein complexes to specific genomic loci to initiate histone methylation and/or other chromatin modifications. LncRNAs themselves function as tumor suppressors or oncogenes, depending on the gene regulatory networks they govern. We identified lnc00673 (ERRLR01) as a marker of overall survival (OS) in breast cancer patients. Specifically, ERRLR01 levels were elevated in triple-negative breast cancer (TNBC) as compared to Luminal- A, Luminal-B, and HER2 breast cancer subtypes...
August 10, 2017: Transcription
https://www.readbyqxmd.com/read/28795272/pet-imaging-on-dynamic-metabolic-changes-after-combination-therapy-of-paclitaxel-and-the-traditional-chinese-medicine-in-breast-cancer-bearing-mice
#9
Yao Chen, Ling Wang, Hao Liu, Fahuan Song, Caiyun Xu, Kai Zhang, Qing Chen, Shuang Wu, Yunqi Zhu, Ying Dong, Min Zhou, Hong Zhang, Mei Tian
PURPOSE: The aim of the study was to non-invasively evaluate the anticancer activity of a traditional Chinese medicine-Huaier, combined with paclitaxel (PTX) in breast cancer bearing mice by detecting dynamic metabolic changes with positron emission tomography (PET). PROCEDURES: Balb/c nude mice were randomly divided into one of the four groups: Huaier, PTX, PTX + Huaier, or the control. PET imaging with 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) was performed to monitor the metabolic changes in BT474 (luminal B) and MDA-MB-231 (triple-negative) breast cancer xenografts...
August 9, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28794686/tumor-infiltrating-leukocyte-density-is-independent-of-tumor-grade-and-molecular-subtype-in-aggressive-breast-cancer-of-western-kenya
#10
Rispah T Sawe, Simeon K Mining, Ayub V Ofulla, Kirtika Patel, Bernard Guyah, David Chumba, Jenifer R Prosperi, Maggie Kerper, Zonggao Shi, Mayra Sandoval-Cooper, Katherine Taylor, Sunil Badve, M Sharon Stack, Laurie E Littlepage
BACKGROUND: Tumors commonly are infiltrated by leukocytes, or tumor infiltrating leukocytes (TILs). It remains unclear, however, if the density and type of individual TILs has a direct or simply correlative role in promoting poor prognosis in breast cancer patients. Breast cancer in Kenyan women is aggressive with presentation at a young age, with advanced grade (grade III), large tumor size (>2.0 cm), and poor prognosis. We previously observed that the tumors were predominantly estrogen receptor positive (ER+) but also included both a high percentage of triple negative tumors and also increased immune cell infiltration within the tumors...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28791482/assessment-of-ki67-expression-for-breast-cancer-subtype-classification-and-prognosis-in-the-nurses-health-study
#11
Megan A Healey, Kelly A Hirko, Andrew H Beck, Laura C Collins, Stuart J Schnitt, A Heather Eliassen, Michelle D Holmes, Rulla M Tamimi, Aditi Hazra
PURPOSE: Ki67 is a proliferation marker commonly assessed by immunohistochemistry in breast cancer, and it has been proposed as a clinical marker for subtype classification, prognosis, and prediction of therapeutic response. However, the clinical utility of Ki67 is limited by the lack of consensus on the optimal cut point for each application. METHODS: We assessed Ki67 by immunohistochemistry using Definiens digital image analysis (DIA) in 2653 cases of incident invasive breast cancer diagnosed in the Nurses' Health Study from 1976 to 2006...
August 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28789929/commentary-on-comprehensive-transcriptional-analysis-of-early-stage-urothelial-carcinoma-hedegaard-j-lamy-p-nordentoft-i-algaba-f-h%C3%A3-yer-s-ulh%C3%A3-i-bp-vang-s-reinert-t-hermann-gg-mogensen-k-thomsen-mb-nielsen-mm-marquez-m-segersten-u-aine-m-h%C3%A3-glund-m-birkenkamp
#12
Byron H Lee
Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into 3 major classes with basal- and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Analysis of transcript variants revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions...
August 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28783154/informed-proteomics-open-source-software-package-for-top-down-proteomics
#13
Jungkap Park, Paul D Piehowski, Christopher Wilkins, Mowei Zhou, Joshua Mendoza, Grant M Fujimoto, Bryson C Gibbons, Jared B Shaw, Yufeng Shen, Anil K Shukla, Ronald J Moore, Tao Liu, Vladislav A Petyuk, Nikola Tolić, Ljiljana Paša-Tolić, Richard D Smith, Samuel H Payne, Sangtae Kim
Top-down proteomics, the analysis of intact proteins in their endogenous form, preserves valuable information about post-translation modifications, isoforms and proteolytic processing. The quality of top-down liquid chromatography-tandem MS (LC-MS/MS) data sets is rapidly increasing on account of advances in instrumentation and sample-processing protocols. However, top-down mass spectra are substantially more complex than conventional bottom-up data. New algorithms and software tools for confident proteoform identification and quantification are needed...
August 7, 2017: Nature Methods
https://www.readbyqxmd.com/read/28781022/determinants-of-last-line-treatment-in-metastatic-breast-cancer
#14
Marika Cinausero, Lorenzo Gerratana, Elisa De Carlo, Donatella Iacono, Marta Bonotto, Valentina Fanotto, Vanessa Buoro, Debora Basile, Maria Grazia Vitale, Karim Rihawi, Gianpiero Fasola, Fabio Puglisi
BACKGROUND: In metastatic breast cancer (MBC) patients, the identification of factors helping clinicians in the choice between active therapy versus best supportive care is needed clinically. The aim of the present study was to identify the clinicopathologic factors that could improve the prognostic valuation of MBC patients and clinical decision-making at the end of life. PATIENTS AND METHODS: The present study analyzed data from a retrospective series of 522 MBC patients treated at the oncology department (University Hospital of Udine) from January 2004 to June 2014...
July 14, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28776547/a-retrospective-survival-analysis-of-anatomic-and-prognostic-stage-group-based-on-the-american-joint-committee-on-cancer-8th-edition-cancer-staging-manual-in-luminal-b-human-epidermal-growth-factor-receptor-2-negative-breast-cancer
#15
Ling Xu, Jiang-Hong Li, Jing-Ming Ye, Xue-Ning Duan, Yuan-Jia Cheng, Ling Xin, Qian Liu, Bin Zhou, Yin-Hua Liu
BACKGROUND: Current understanding of tumor biology suggests that breast cancer is a group of diseases with different intrinsic molecular subtypes. Anatomic staging system alone is insufficient to provide future outcome information. The American Joint Committee on Cancer (AJCC) expert panel updated the 8th edition of the staging manual with prognostic stage groups by incorporating biomarkers into the anatomic stage groups. In this study, we retrospectively analyzed the data from our center in China using the anatomic and prognostic staging system based on the AJCC 8th edition staging manual...
August 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28770103/subclonal-analysis-in-a-lobular-breast-cancer-with-classical-and-solid-growth-pattern-mimicking-a-solid-papillary-carcinoma
#16
Matthias Christgen, Stephan Bartels, Jana Lisa van Luttikhuizen, Maximilian Schieck, Stefanie Pertschy, Sudip Kundu, Ulrich Lehmann, Bjoern Sander, Enrico Pelz, Florian Länger, Brigitte Schlegelberger, Doris Steinemann, Hans Kreipe
Recently, a new variant of invasive lobular breast cancer (ILBC) with solid-papillary-like growth pattern has been described. We present a case of ILBC with solid-papillary-like growth pattern in the main tumour mass and classical invasive lobular growth pattern in adjacent satellite foci. The two tumour components were subjected to comprehensive molecular analyses. Both components were ER/PR-positive, HER2-negative, and showed a complete loss of E-cadherin and beta-catenin protein expression, as determined by immunohistochemistry...
July 2017: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/28768217/randomised-open-label-phase-ii-study-comparing-the-efficacy-and-the-safety-of-cabazitaxel-versus-weekly-paclitaxel-given-as-neoadjuvant-treatment-in-patients-with-operable-triple-negative-or-luminal-b-her2-negative-breast-cancer-genevieve
#17
Sherko Kümmel, Stefan Paepke, Jens Huober, Christian Schem, Michael Untch, Jens Uwe Blohmer, Wolfgang Eiermann, Bernd Gerber, Claus Hanusch, Jörn Hilfrich, Christian Jackisch, Andreas Schneeweiss, Carsten Denkert, Knut Engels, Peter Klare, Peter A Fasching, Gunter von Minckwitz, Nicole Burchardi, Sibylle Loibl
BACKGROUND: The GENEVIEVE study compared the pathological complete response (pCR) rate (ypT0/is ypN0/+) in patients with operable human epidermal growth factor receptor 2 (HER2)-negative breast cancer (BC) treated with either cabazitaxel or paclitaxel. METHODS: GENEVIEVE was a prospective, multicentre, randomised, open-label, phase II study comparing the efficacy and the safety of four 3-weekly cycles cabazitaxel versus 12 weeks of paclitaxel given as neoadjuvant treatment...
July 30, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28766130/detection-of-multicentric-and-contralateral-breast-cancers-on-mri-based-on-primary-cancer-biomarker-status-will-this-change-surgical-or-medical-management
#18
Arti R Jonna, Kenny Q Sam, Lilian O Ebuoma, Emily L Sedgwick, Tao Wang, Ana P Benveniste
PURPOSE: The utilization of staging preoperative breast MRI in biopsy-proven cancer patients varies based on institution and individual clinicians. It is unclear whether primary breast cancer subtype influences a clinician's decision to obtain a preoperative breast MRI based on likelihood of multicentric or contralateral disease, which may change surgical or medical management. Our purpose was to compare the four main breast cancer subtypes in our patient population (i.e., luminal A, luminal B, HER2 enriched and triple-negative) who underwent pretreatment staging MRIs to determine whether certain breast cancer subtypes are more likely to have multicentric or contralateral disease...
August 1, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28764784/e-cadherin-expression-phenotypes-associated-with-molecular-subtypes-in-invasive-non-lobular-breast-cancer-evidence-from-a-retrospective-study-and-meta-analysis
#19
Jiang-Bo Liu, Chen-Yi Feng, Miao Deng, Dong-Feng Ge, De-Chun Liu, Jian-Qiang Mi, Xiao-Shan Feng
BACKGROUND: This retrospective study and meta-analysis was designed to explore the relationship between E-cadherin (E-cad) expression and the molecular subtypes of invasive non-lobular breast cancer, especially in early-stage invasive ductal carcinoma (IDC). METHODS: A total of 156 post-operative cases of early-stage IDCs were retrospectively collected for the immunohistochemistry (IHC) detection of E-cad expression. The association of E-cad expression with molecular subtypes of early-stage IDCs was analyzed...
August 1, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28761685/two-year-clinical-outcomes-of-patients-treated-with-the-dual-therapy-stent-in-a-1000-patient-all-comers-registry
#20
Deborah N Kalkman, Pier Woudstra, Ian B A Menown, Peter den Heijer, Arnoud Wj Van't Hof, Andrejs Erglis, Harry Suryapranata, Karin E Arkenbout, Andrés Iñiguez, Philippe Muller, Jan G Tijssen, Marcel A M Beijk, Robbert J de Winter
OBJECTIVE: The dual-therapy stent combines an abluminal biodegradable drug-eluting coating, with a 'pro-healing' luminal layer. This bioengineered layer attracts circulating endothelial progenitor cells that can differentiate into normal endothelium. Rapid endothelialisation of the stent might allow safe short dual antiplatelet therapy. We aim to assess clinical outcomes in patients treated with this novel device at 2-year follow-up. METHODS: A total of 1000 patients were included in the REMEDEE Registry to evaluate clinical outcomes after treatment with the dual-therapy stent...
2017: Open Heart
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