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alcohol withdrawal syndrome

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https://www.readbyqxmd.com/read/29658504/-alcohol-withdrawal-syndrome-dynamics-during-treatment-with-nooclerin-deanoli-aceglumas
#1
T V Agibalova, O Zh Buzik, O V Rychkova, A V Smyshlyaev, V V Rumbesht
AIM: To study the efficacy of nooclerin (deanoli aceglumas) in alcohol withdrawal syndrome assessed by clinical and biochemical characteristics. MATERIAL AND METHODS: A multicenter, open, randomized, comparative study of nooclerin in the complex treatment of alcohol withdrawal syndrome included 90 patients. The patients were randomized into nooclerin group (n=55) and control group (n=35). RESULTS AND CONCLUSION: Nooclerin reduced alcohol withdrawal symptoms more significantly throughout the whole study period...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29604618/an-open-prospective-pilot-study-of-a-herbal-combination-relief-as-a-supportive-dietetic-measure-during-alcohol-withdrawal
#2
Kenza Mansoor, Fadi Qadan, Andreas Hinum, Caroline Schneider, Klaus Hechenbichler, Mathias Schmidt, Georg Linsinger, Khalid Matalka
OBJECTIVE: A herbal combination (saffron extract, passion flower herb extract, cocoa seed extract, radish extract and black cumin extract) called "Relief" was designed as a supportive therapy of alcohol withdrawal syndrome (AWS). This combination was based on the scientific evidence of each constituent effect on AWS-like symptoms. In addition, our preclinical studies have shown the effectiveness of Relief on AWS detoxification. The rationale of the study was to document whether the oral intake of the designed content of Relief could have a positive effect on the course of alcohol detoxification by reducing some of the AWS in hospitalized patients...
March 1, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29595541/co-administration-of-amphetamine-with-alcohol-results-in-decreased-alcohol-withdrawal-severity-in-adolescent-rats
#3
Shayna Popkin, Alex Nanchanatt, Madelyn I Mauterer, Dennis E Rhoads
Simultaneous use of stimulants and alcohol is a growing problem, particularly among older adolescents already prone to binge alcohol consumption. Adolescent rats consume high levels of alcohol when administered in a liquid diet and develop a strong alcohol withdrawal syndrome. We exploited this system to administer amphetamine in combination with alcohol and to test the effect of co-administration of amphetamine on alcohol withdrawal-induced hypoactivity and overall withdrawal severity. The presence of dietary amphetamine (≤40 mg/l) had no effect on consumption of control or alcohol-containing diets...
March 27, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29593851/acupuncture-for-alcohol-use-disorder
#4
Pei Chen, Jing Li, Xiao Han, Dennis Grech, Ming Xiong, Alex Bekker, Jiang-Hong Ye
Alcohol use disorder (AUD) is a common medical and social problem, affecting about 240 million people in the world. To address this major health concern, the currently available treatments for AUD need to be improved. Acupuncture, a popular form of complementary and alternative therapy, is emerging as an effective treatment for AUD. This review summarizes how preclinical and clinical studies are related to the application of acupuncture for AUD. These studies suggest that if used correctly, acupuncture may effectively reduce alcohol intake, attenuate alcohol withdrawal syndrome, and rebalance AUD-induced maladaptation in neurotransmitters and hormones in related brain areas...
2018: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29574507/new-steps-for-treating-alcohol-use-disorder
#5
REVIEW
Erin J Campbell, Andrew J Lawrence, Christina J Perry
Alcohol use disorder is a complex syndrome with multiple treatment points including drug-induced pathology, withdrawal management, behavioral/cognitive strategies, and relapse prevention. These different components may be complicated by genotype and phenotype. A huge milestone for the treatment of alcohol use disorder across several countries in the last 10 years was the introduction of practice guidelines integrating clinical expertise and research evidence. These provide a summary of interventions that have been shown to be effective following rigorous and replicated clinical trials...
March 25, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29573476/the-multidisciplinary-support-in-preventing-alcohol-relapse-after-liver-transplantation-a-single-centre-experience
#6
M L Attilia, B Lattanzi, R Ledda, A Galli, A Farcomeni, C Rotondo, V Di Gregorio, G Mennini, E Poli, F Attilia, S Ginanni Corradini, M Rossi, M Merli
BACKGROUND AND AIM: Alcoholic liver disease (ALD) represents a frequent indication for liver transplantation(LT). Since 2004, we have adopted a program of multidisciplinary support(MS) to assist patients undergoing LT for ALD. We aimed at analysing the relapse rate and the risk factors for relapse. The relapse rate was also compared with that of a historical group of patients who underwent transplantation. Their survival rate was also analysed. PATIENTS AND METHODS: Consecutive patients with ALD transplanted from 2004 were included...
March 24, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29543325/pharmacological-interventions-for-benzodiazepine-discontinuation-in-chronic-benzodiazepine-users
#7
REVIEW
Lone Baandrup, Bjørn H Ebdrup, Jesper Ø Rasmussen, Jane Lindschou, Christian Gluud, Birte Y Glenthøj
BACKGROUND: Prolonged treatment with benzodiazepines is common practice despite clinical recommendations of short-term use. Benzodiazepines are used by approximately 4% of the general population, with increased prevalence in psychiatric populations and the elderly. After long-term use it is often difficult to discontinue benzodiazepines due to psychological and physiological dependence. This review investigated if pharmacological interventions can facilitate benzodiazepine tapering. OBJECTIVES: To assess the benefits and harms of pharmacological interventions to facilitate discontinuation of chronic benzodiazepine use...
March 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29529713/routine-screening-and-related-interventions-significantly-improve-the-effectiveness-of-emergency-department-detection-and-management-of-alcohol-withdrawal-syndrome
#8
Julia M Lappin, Muhammad H Ayub, David Rogers, Madeleine Morgan, Jean-Yves Kanyamibwa, Anthony Shakeshaft
OBJECTIVE: To evaluate the effectiveness of a routine screening and triage tool for alcohol withdrawal syndrome (AWS) in improving clinical care delivery in an ED setting. METHODS: In a regional ED in Australia, a screening and triage tool for AWS was introduced to routine ED assessment for a 13 week period. Subjects were all presentations to ED aged 16 and above with relevant presenting problems during the pre-intervention phase (1 January 2015-31 December 2016) and the post-intervention phase (8 August 2016-4 November 2016)...
March 12, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29517626/weekend-effect-in-acute-pancreatitis-related-hospital-admissions-in-the-united-states-an-analysis-of-the-nationwide-inpatient-sample
#9
Prabin Sharma, Rodrigo Aguilar, Mark Abi Nader, Shaheryar Siddiqui, Ramkaji Baniya, Sanjeeb Sudarshan Bhandari, Carmen Elena Cervantes, Ricardo Correa, Amir Masoud
OBJECTIVE: This study aimed to assess the difference in overall outcomes between weekend admissions for acute pancreatitis (AP) and weekday admissions. METHODS: Between 2005 and 2012, data were extracted from the Nationwide Inpatient Sample on adult patients with AP. Exclusion criteria were applied for chronic pancreatitis and other pancreatic and biliary malignancies. In-hospital mortality, length of stay, hospitalization costs, comorbidities, complications, and intervention rates were compared between the weekend and weekday admissions...
April 2018: Pancreas
https://www.readbyqxmd.com/read/29491698/current-practice-patterns-in-the-management-of-alcohol-withdrawal-syndrome
#10
Yoonsun Mo, Michael C Thomas, Corey S Laskey, Natalia Shcherbakova, Megan L Bankert, Robert H Halloran
Objective: The aim of this study was to examine current practice patterns surrounding the management of alcohol withdrawal syndrome (AWS) in the Northeast region of the United States. Methods: A survey questionnaire with several treatment options related to current practice in the management of AWS was developed. All hospitals with 100 beds or more located in the Northeast region were selected, and 512 surveys were mailed to pharmacy directors of those hospitals...
March 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29478862/an-exploratory-study-of-candidate-gene-s-for-delirium-tremens-adding-the-new-cholinergic-dimension-to-the-conundrum
#11
Savita Malhotra, Debasish Basu, Abhishek Ghosh, Madhu Khullar, Neera Chugh, Neeraj Kakkar
BACKGROUND AND AIMS: Delirium Tremens (DT) is the most severe form of alcohol withdrawal syndrome, with a potential risk of mortality. Search for the predictors of DT led to study of candidate genes, with inconsistent and inconclusive results. This study aimed to explore the association of various candidate gene polymorphisms and DT in a case-control design. METHODS: This was a genetic association study with a case control design. Two hundred ten Alcohol dependent (AD) male subjects and 200 age matched controls were recruited...
February 12, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29462108/disulfiram-attenuates-morphine-or-methadone-withdrawal-syndrome-in-mice
#12
Anna de Cordé, Paweł Krząścik, Renata Wolińska, Patrycja Kleczkowska, Małgorzata Filip, Magdalena Bujalska-Zadrożny
Taking opioids is often accompanied by the development of dependence. Unfortunately, treatment of opioid dependence is difficult, particularly because of codependence - for example, on alcohol or other drugs of abuse. In the presented study, we analyzed the potential influence of disulfiram, a drug used to aid the management of alcoholism, on opioid abstinence syndrome, which occurs as a result of opioid withdrawal. Opioid dependence in mice was induced by subcutaneous administration of either morphine or methadone at a dose of 48 mg/kg for 10 consecutive days...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29336434/acg-clinical-guideline-alcoholic-liver-disease
#13
Ashwani K Singal, Ramon Bataller, Joseph Ahn, Patrick S Kamath, Vijay H Shah
Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver, alcoholic hepatitis (AH), and cirrhosis with its complications. Most patients are diagnosed at advanced stages and data on the prevalence and profile of patients with early disease are limited. Diagnosis of ALD requires documentation of chronic heavy alcohol use and exclusion of other causes of liver disease. Prolonged abstinence is the most effective strategy to prevent disease progression. AH presents with rapid onset or worsening of jaundice, and in severe cases may transition to acute on chronic liver failure when the risk for mortality, depending on the number of extra-hepatic organ failures, may be as high as 20-50% at 1 month...
February 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29317849/is-medical-treatment-of-alcohol-withdrawal-syndrome-a-stag-hunt-challenges-and-opportunities-in-managing-risk-and-uncertainty-in-addiction-cessation
#14
Roger Lee Mendoza
Purpose: While the individual and social costs of alcoholism or alcohol use disorder are well established, few are aware that medical problems can arise during detoxification, some of which can be life-threatening. This study determines if sustained treatment for Alcohol Withdrawal Syndrome (AWS) might be based on the strategic choices and expectations of patients and health care providers alike, as well as the risk mitigation options available to them. Design/approach: AWS was modeled as a Stag Hunt to explain both risk and decision-making in medical treatments for detoxification, since it can deduce a set of equilibrium strategies available to both patient and provider...
2018: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/29302560/benzodiazepine-maintenance-for-alcohol-dependence-a-case-series
#15
Shivanand Kattimani, Balaji Bharadwaj, Anand Babu Arun
Alcohol addiction is a chronic relapsing syndrome. Benzodiazepines remain as the mainstay for detoxification, taking care of the acute withdrawal syndrome. There is fear of dependence and abuse of benzodiazepines on prolonged use. Here, we selectively interviewed ten cases who were on longer duration of benzodiazepines to elicit their potential perceived benefits, attitudes, and any adverse effect. Three patients experienced adverse effects. None of them had features of benzodiazepine dependence. We opine that in select cases, benzodiazepine use should persist beyond detox period, and its benefits continue beyond the acute withdrawal phase while monitoring their safety/adverse effects...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29276297/patient-outcomes-associated-with-phenobarbital-use-with-or-without-benzodiazepines-for-alcohol-withdrawal-syndrome-a-systematic-review
#16
Drayton A Hammond, Jordan M Rowe, Adrian Wong, Tessa L Wiley, Kristen C Lee, Sandra L Kane-Gill
Purpose: Benzodiazepines are the drug of choice for alcohol withdrawal syndrome (AWS); however, phenobarbital is an alternative agent used with or without concomitant benzodiazepine therapy. In this systematic review, we evaluate patient outcomes with phenobarbital for AWS. Methods: Medline, Cochrane Library, and Scopus were searched from 1950 through February 2017 for controlled trials and observational studies using ["phenobarbital" or "barbiturate"] and ["alcohol withdrawal" or "delirium tremens...
October 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29274671/incidence-rates-of-admissions-associated-with-alcohol-withdrawal-syndrome-in-spain-analysis-of-minimum-basic-data-set-1999-2010
#17
Raquel Gómez-Méndez, Rafael Monte-Secades, Pablo Ventura-Valcárcel, Ramón Rabuñal-Rey, Héctor Guerrero-Sande, Antonio J Chamorro-Fernández, Sonia Pértega-Díaz
BACKGROUND: There are no data on the incidence of admissions associated with alcohol withdrawal syndrome (AWS) or about its trend over time in Spain. OBJECTIVE: To analyze the characteristics, incidence rates and trends over time of hospital admissions associated with AWS in Spanish public hospitals. MATERIAL AND METHOD: Analysis from the Spanish public hospitals minimum basic data set of hospital admissions with AWS (CIE9-MC 291.81), alcohol withdrawal delirium (CIE9-MC 291...
December 20, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29219048/sodium-oxybate-therapy-for-the-treatment-of-alcohol-withdrawal-syndrome-and-the-maintenance-of-alcohol-abstinence
#18
Carmen Mannucci, Simona Pichini, Elvira Ventura Spagnolo, Fabrizio Calapai, Sebastiano Gangemi, Michele Navarra, Gioacchino Calapai
BACKGROUND: Gamma-hydroxybutyrate (GHB or sodium oxybate) is both an exogenous and endogenous molecule with neuromodulator properties. In the United States, GHB is an approved drug for the treatment of narcolepsy and narcolepsy with cataplexy in adults. In some European Union countries, sodium oxybate is applied for the treatment of opioid and alcohol withdrawal. OBJECTIVE: The aim of the present review was to describe the state of art of the pre-clinical research and the clinical evidence related to GHB used alone or in combination with other treatments in alcohol withdrawal syndrome and alcohol abstinence maintenance...
December 7, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29200566/opioid-withdrawal-presenting-as-delirium-and-role-of-buprenorphine-a-case-series
#19
Sourav Das, Divyashree Sah, Shiladitya Nandi, Payel Das
Opioid withdrawal is very rarely characterized by delirium unlike alcohol or benzodiazepine withdrawal. PubMed search through October 2016 reveals only two case series on delirium as feature of withdrawal in opioid dependence syndrome. We report two cases of opioid withdrawal (heroin) presenting with delirium when low-dose buprenorphine (2 mg/day) was added. Both the cases had no other substance abuse history and nil contributory past and family history. Both of them were improved after increasing the buprenorphine dosage to 6-8 mg/day...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29200055/the-addition-of-dexmedetomidine-as-an-adjunctive-therapy-to-benzodiazepine-use-in-alcohol-withdrawal-syndrome-a-literature-review
#20
Tarenne A Ferenchak
Alcohol withdrawal syndrome (AWS) is commonly encountered in the intensive care unit population. Currently, the mainstay treatment for AWS is the use of benzodiazepines. However, some patients are refractory to benzodiazepine treatment due to heavy alcohol abuse. In addition, escalating doses of benzodiazepines can lead to respiratory depression, requiring intubation and mechanical ventilation. Intubation and mechanical ventilation increase both intensive care unit and hospital length of stay. The addition of pharmacological agents to reduce the amount of benzodiazepine use in AWS has recently been studied...
October 2017: Journal of Addictions Nursing
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