keyword
MENU ▼
Read by QxMD icon Read
search

Pals

keyword
https://www.readbyqxmd.com/read/28821582/identification-of-%C3%AE-enolase-as-a-prognostic-and-diagnostic-precancer-biomarker-in-oral-submucous-fibrosis
#1
Swarnendu Bag, Debabrata Dutta, Amrita Chaudhary, Bidhan Chandra Sing, Mousumi Pal, Ajoy Kumar Ray, Rita Banerjee, Ranjan Rashmi Paul, Amit Basak, Amit Kumar Das, Jyotirmoy Chatterjee
AIMS: Diagnostic ambiguities regarding the malignant potentiality of oral submucous fibrosis (OSF), an oral precancerous condition having dysplastic and non-dysplastic isoforms are the major failure for early intervention of oral squamous cell carcinoma (OSCC) patients. Our goal is to identify proteomic signatures from biopsies that can be used as precancer diagnostic marker for patient suffering from OSF. METHODS: The high throughput techniques adopting de novo peptide sequencing (1D SDS-PAGE coupled nanoLC MALDI tandem mass spectrometry (MS/MS)-based peptide mass fingerprint), immunohistochemistry (IHC), Western blot (WB) and real-time PCR (RT-PCR) analysis are considered for such biomarker identification and multilevel validations...
August 18, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28819877/engineering-of-escherichia-coli-for-the-synthesis-of-n-hydroxycinnamoyl-tryptamine-and-serotonin
#2
Su Jin Lee, Geun-Young Sim, Youngshim Lee, Bong-Gyu Kim, Joong-Hoon Ahn
Plants synthesize various phenol amides. Among them, hydroxycinnamoyl (HC) tryptamines and serotonins exhibit antioxidant, anti-inflammatory, and anti-atherogenic activities. We synthesized HC-tryptamines and HC-serotonin from several HCs and either tryptamine or serotonin using Escherichia coli harboring the 4CL (4-coumaroyl CoA ligase) and CaHCTT [hydroxycinnamoyl-coenzyme A:serotonin N-(hydroxycinnamoyl)transferase] genes. E. coli was engineered to synthesize N-cinnamoyl tryptamine from glucose. TDC (tryptophan decarboxylase) and PAL (phenylalanine ammonia lyase) along with 4CL and CaHCTT were introduced into E...
August 17, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28817643/peripheral-clinic-versus-centralized-laboratory-based-xpert-mtb-rif-performance-experience-gained-from-a-pragmatic-stepped-wedge-trial-in-botswana
#3
Tefera Agizew, Rosanna Boyd, Ndwapi Ndwapi, Andrew Auld, Joyce Basotli, Sambayawo Nyirenda, Zegabriel Tedla, Anikie Mathoma, Unami Mathebula, Chawangwa Lesedi, Sherri Pals, Anand Date, Heather Alexander, Thomas Kuebrich, Alyssa Finlay
BACKGROUND: In 2011, the Botswana National Tuberculosis Program adopted World Health Organization guidelines and introduced Xpert MTB/RIF (Xpert) assay to support intensified case finding among people living with HIV enrolling in care. An evaluation was designed to assess performance under operational conditions to inform the national Xpert scale-up. METHODS: Xpert was implemented from August 2012 through November 2014 with 13 GeneXpert instruments (GeneXpert) deployed in a phased approach over nine months: nine centralized laboratory and four point-of-care (POC) peripheral clinics...
2017: PloS One
https://www.readbyqxmd.com/read/28817282/tnf-induced-switching-of-columnar-rectangular-to-hexagonal-assemblies-in-a-new-class-of-triphenylene-based-room-temperature-discotic-liquid-crystals
#4
Monika Gupta, Santosh Prasad Gupta, Santanu Kumar Pal
A straightforward synthesis of triphenylene-based oligomeric systems that self-organize into room temperature columnar structures is presented. The compounds with longer spacer length (m = 10 and 12) exhibit columnar rectangular (Colr) mesophase whereas the compound with m = 8 exists in glassy Colr state. Interestingly, the Colr self-assembly of these compounds switches to columnar hexagonal (Colh) on doping the compounds with 2, 4, 7-trinitrofluorenone (TNF). For the dopant concentration of 1:1 with respect to native compound, an intermediate transition state between Colr and Colh phase was observed which completely transformed into the hexagonal phase on increasing the concentration to 1:2 (compound: TNF) and afterwards...
August 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28816319/novel-multiple-phosphorescence-in-nanostructured-zinc-oxide-and-calculations-of-correlated-colour-temperature
#5
Sagnik Das, Uttam Kumar Ghorai, Rajib Dey, Chandan Kumar Ghosh, Mrinal Pal
The design and development of novel and high quantum efficiency luminescent materials, such as phosphors, having tuneability in properties, have received tremendous interest among scientists. In this paper, we have achieved for the first-time multiple phosphorescence (blue and green) having a life-time of ∼10 μs in nanostructured zinc oxide that was synthesized using an easy and facile sol-gel method. Importantly, the photoluminescence (PL) intensity and the phosphorescence life-time could be tuned by controlling the annealing temperature under a reducing atmosphere...
August 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28816066/stressing-the-epi-genome-dealing-with-ros-in-cancer
#6
Akshay V Bhat, Shainan Hora, Ananya Pal, Sudhakar Jha, Reshma Taneja
SIGNIFICANCE: Growing evidence indicates cross-talk between Reactive oxygen species (ROS) and several key epigenetic processes like DNA methylation, histone modifications and miRNAs in normal physiology and human pathologies including cancer. This review focuses on how ROS-induced oxidative stress, metabolic intermediates and epigenetic processes influence each other in various cancers. Recent Advances: ROS alters chromatin structure and metabolism which impact the epigenetic landscape in cancer cells...
August 17, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28815827/outer-membrane-lipid-homeostasis-via-retrograde-phospholipid-transport-in-escherichia-coli
#7
Rahul Shrivastava, Xiang'Er Jiang, Shu-Sin Chng
Biogenesis of the outer membrane (OM) in Gram-negative bacteria, which is essential for viability, requires the coordinated transport and assembly of proteins and lipids, including lipopolysaccharides (LPS) and phospholipids (PLs), into the membrane. While pathways for LPS and OM protein assembly are well-studied, how PLs are transported to and from the OM is not clear. Mechanisms that ensure OM stability and homeostasis are also unknown. The trans-envelope Tol-Pal complex, whose physiological role has remained elusive, is important for OM stability...
August 16, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28815542/long-noncoding-rnas-in-pluripotency-of-stem-cells-and-cell-fate-specification
#8
Debosree Pal, M R S Rao
Since the annotation of the mouse genome (FANTOM project) [Kawai J et al (2001) Functional annotation of a full-length mouse cDNA collection. Nature 409(6821):685-690] or the human genome [An integrated encyclopedia of DNA elements in the human genome. (2012) Nature 489(7414):57-74; Harrow J et al (2012) GENCODE: the reference human genome annotation for the ENCODE project. Genome Res 22(9):1760-1774], the roles of long noncoding RNAs in coordinating specific signaling pathways have been established in a wide variety of model systems...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28815536/long-noncoding-rna-genome-organization-and-mechanism-of-action
#9
Vijay Suresh Akhade, Debosree Pal, Chandrasekhar Kanduri
For the last four decades, we have known that noncoding RNAs maintain critical housekeeping functions such as transcription, RNA processing, and translation. However, in the late 1990s and early 2000s, the advent of high-throughput sequencing technologies and computational tools to analyze these large sequencing datasets facilitated the discovery of thousands of small and long noncoding RNAs (lncRNAs) and their functional role in diverse biological functions. For example, lncRNAs have been shown to regulate dosage compensation, genomic imprinting, pluripotency, cell differentiation and development, immune response, etc...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28814935/knowledge-and-attitude-of-dental-students-towards-hiv-aids-patients-in-melaka-malaysia
#10
Vijendra Pal Singh, Izni Syazana Osman, Nur Amanina Rahmat, Nur Ashikin Abu Bakar, Nurul Fathin Natasha Abdul Razak, Sowmya Nettem
BACKGROUND: Cross contamination of HIV is a real threat today. Dental treatment often includes direct contact with a patient's blood and saliva, therefore dental professionals can be easily exposed to HIV microorganisms. Hence, it is essential to gain insight into dental students' knowledge and attitude towards HIV patients. METHOD: A cross-sectional survey of 186 clinical year dental students (year 3, 4 and 5) in the 2015-2016 academic session at the Faculty of Dentistry, Melaka-Manipal Medical College (MMMC), Manipal University, Melaka volunteered to participate in the study...
May 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28814160/elucidation-of-molecular-mechanism-of-stability-of-the-heme-regulated-eif2%C3%AE-kinase-upon-binding-of-its-ligand-hemin-in-its-catalytic-kinase-domain
#11
Varsha Bhavnani, Kaviraj Swarnendu, Priyabrata Panigrahi, C G Suresh, SuneelShekar Yapara, Jayanta Pal
The eIF2α kinase activity of the heme-regulated inhibitor (HRI) is regulated by heme which makes it a unique member of the family of eIF2α kinases. Since heme concentrations create an equilibrium for the kinase to be active/inactive, it becomes important to study the heme binding effects upon the kinase and understanding its mechanism of functionality. In the present study, we report the thermostability achieved by the catalytic kinase domain of HRI (HRI.CKD) upon ligand (heme) binding. Our CD data demonstrates that the HRI...
August 17, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28812901/behavior-of-methylammonium-dipoles-in-mapbx3-x-br-and-i
#12
Sharada Govinda, Bhushan P Kore, Menno Bokdam, Pratibha Mahale, Abhinav Kumar, Somnath Pal, Biswajit Bhattacharyya, Jonathan Lahnsteiner, Georg Kresse, Cesare Franchini, Anshu Pandey, D D Sarma
Dielectric constants of MAPbX3 (X = Br, I) in the 1 kHz-1 MHz range show strong temperature dependence near room temperature, in contrast to the nearly temperature-independent dielectric constant of CsPbBr3. This strong temperature dependence for MAPbX3 in the tetragonal phase is attributed to the MA(+) dipoles rotating freely within the probing time scale. This interpretation is supported by ab initio molecular dynamics simulations on MAPbI3 that establish these dipoles as randomly oriented with a rotational relaxation time scale of ∼7 ps at 300 K...
August 18, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28812895/correlating-free-volume-hole-distribution-to-the-glass-transition-temperature-of-epoxy-polymers
#13
Amin Aramoon, Timothy D Breitzman, Christopher F Woodward, Jaafar A El-Awady
A new algorithm is developed to quantify the free-volume hole distribution and its evolution in coarse-grained molecular dynamics simulations of polymeric networks. This is achieved by analyzing the geometry of the network rather than a voxelized image of the structure to accurately and efficiently find and quantify free-volume hole distributions within large scale simulations of polymer networks. The free-volume holes are quantified by fitting the largest ellipsoids and spheres in the free-volumes between polymer chains...
August 16, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28812162/molecular-characterization-of-a-beet-ringspot-nepovirus-isolated-from-begonia-ricinifolia-in-hungary
#14
Szilvia Kis, Pál Salamon, Viktor Kis, György Szittya
A nepovirus was isolated from Begonia ricinifolia showing chlorotic ringspot and line pattern symptoms. The purified virus had spherical particles of ca. 30 nm and contained a single coat protein subunit of ca. 56 kDa. The complete nucleotide sequence of the bipartite viral genome was determined. RNA 1 is 7394 nucleotides long, flanked by 5' and 3' untranslated regions (UTR), and followed by a 3' poly-A tail. It contains a single 6810 nt long open reading frame (ORF), which is translated into a 255 kDa polyprotein composed of 2269 amino acids...
August 10, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28811888/performance-test-and-verification-of-an-off-the-shelf-automated-avian-radar-tracking-system
#15
Roel May, Yngve Steinheim, Pål Kvaløy, Roald Vang, Frank Hanssen
Microwave radar is an important tool for observation of birds in flight and represents a tremendous increase in observation capability in terms of amount of surveillance space that can be covered at relatively low cost. Based on off-the-shelf radar hardware, automated radar tracking systems have been developed for monitoring avian movements. However, radar used as an observation instrument in biological research has its limitations that are important to be aware of when analyzing recorded radar data. This article describes a method for exploring the detection capabilities of a dedicated short-range avian radar system used inside the operational Smøla wind-power plant...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28811689/expression-of-telomere-binding-proteins-rap1-and-pot1-in-renal-cell-carcinoma-and-their-correlation-with-clinicopathological-parameters
#16
Deeksha Pal, Shrawan Kumar Singh, Nandita Kakkar, Rajendra Prasad
Telomere stability is indispensable for continuous proliferation of cells. Telomere structure is maintained by group of six proteins termed as shelterin. RAP1 and POT1 proteins are significant members of shelterin complex. Expression of RAP1 and POT1 are crucial for telomere maintenance and hence uncontrolled division of cells. Notably, expression of RAP1 and POT1 is unknown in renal cell carcinoma (RCC). In view of these facts, the present study was initiated to investigate the expression of RAP1 and POT1 in RCC and their relationships with clinicopathological features...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28811489/high-temperature-stress-during-flowering-and-grain-filling-offsets-beneficial-impact-of-elevated-co2-on-assimilate-partitioning-and-sink-strength-in-rice
#17
Ashish K Chaturvedi, Rajeev N Bahuguna, Divya Shah, Madan Pal, S V Krishna Jagadish
Elevated [CO2] (e[CO2]) environments have been predicted to improve rice yields under future climate. However, a concomitant rise in temperature could negate e[CO2] impact on plants, presenting a serious challenge for crop improvement. High temperature (HT) stress tolerant NL-44 and high yielding basmati Pusa 1121 rice cultivars, were exposed to e[CO2] (from panicle initiation to maturity) and a combination of e[CO2] + HT (from heading to maturity) using field based open top chambers. Elevated [CO2] significantly increased photosynthesis, seed-set, panicle weight and grain weight across both cultivars, more prominently with Pusa 1121...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811200/globular-adiponectin-reverses-osteo-sarcopenia-and-altered-body-composition-in-ovariectomized-rats
#18
Shyamsundar Pal China, Subhashis Pal, Sourav Chattopadhyay, Konica Porwal, Sapana Kushwaha, Sharmishtha Bhattacharyya, Monika Mittal, Anagha A Gurjar, Tarun Barbhuyan, Abhishek K Singh, Arun K Trivedi, Jiaur R Gayen, Sabyasachi Sanyal, Naibedya Chattopadhyay
Adiponectin regulates various metabolic processes including glucose flux, lipid breakdown and insulin response. We recently reported that adiponectin receptor1 (adipoR1) activation by a small molecule reverses osteopenia in leptin receptor deficient db/db (diabetic) mice. However, the role of adiponectin in bone metabolism under the setting of post-menopausal (estrogen-deficiency) osteopenia and associated metabolic derangements has not been studied. Here, we studied the therapeutic effect of the globular form of adiponectin (gAd), which is predominantly an adipoR1 agonist, in aged ovariectomized (OVX) rats and compared it with standard-of-care anti-osteoporosis drugs...
August 12, 2017: Bone
https://www.readbyqxmd.com/read/28808992/a-photoaffinity-labeling-based-chemoproteomics-strategy-for-unbiased-target-deconvolution-of-small-molecule-drug-candidates
#19
Jason R Thomas, Scott M Brittain, Jennifer Lipps, Luis Llamas, Rishi K Jain, Markus Schirle
The combination of photoaffinity labeling (PAL) and quantitative chemoproteomics enables the comprehensive, unbiased determination of protein interaction profiles to support target identification of bioactive small molecules. This approach is amenable to cells in culture and compatible with pharmacologically relevant transmembrane target classes like G-protein coupled receptors and ions channels which have been notoriously hard to access by conventional chemoproteomics approaches. Here, we describe a strategy that combines PAL probe titration and competition with excess parental compounds with the goal of enabling the identification of specific interactors as well as assessing the functional relevance of a binding event for the phenotype under investigation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28807703/is-early-palliative-care-feasible-in-patients-with-multiple-myeloma
#20
Josep Porta-Sales, Maria Guerrero-Torrelles, Deborah Moreno-Alonso, Josep Sarra-Escarre, Victòria Clapés-Puig, Jordi Trelis-Navarro, Anna Sureda-Balarí, Alberto Fernández De Sevilla-Ribosa
CONTEXT: Evidence for the benefits of early palliative care (EPC) in patients with solid tumors is strong, but EPC has received scant attention in hematological malignancies. OBJECTIVE: To assess the benefits of outpatient-based EPC for symptom control in patients with multiple myeloma. METHODS: Retrospective study of patients attending the Multiple Myeloma Palliative Care Clinic (MM-PAL) at our hospital in the year 2013 (February 1 - December 31)...
August 11, 2017: Journal of Pain and Symptom Management
keyword
keyword
13411
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"