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https://www.readbyqxmd.com/read/29244947/a-new-strategy-for-in-vitro-determination-of-carbonic-anhydrase-activity-from-analysis-of-oxygen-18-isotopes-of-co2
#1
Chiranjit Ghosh, Santanu Mandal, Mithun Pal, Manik Pradhan
The oxygen-18 isotopic (18O) composition in CO2 provides important insight into the variation of rate in isotopic fractionation reaction regulated by carbonic anydrase (CA) metalloenzyme. This work aims to employ 18O-isotope ratio-based analytical method for quantitative estimation of CA activity in erythrocytes for clinical testing purposes. Here, a new method has been developed that contains the measurements of 18O/16Oisotope ratios during oxygen-18 isotopic exchange between 12C16O16O and H218O of in-vitro biochemical reaction controlled by erythrocytes CA and estimation of enzymatic activity of CA from the isotopic composition of CO2...
December 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29240760/novel-linear-motif-filtering-protocol-reveals-the-role-of-the-lc8-dynein-light-chain-in-the-hippo-pathway
#2
Gábor Erdős, Tamás Szaniszló, Mátyás Pajkos, Borbála Hajdu-Soltész, Bence Kiss, Gábor Pál, László Nyitray, Zsuzsanna Dosztányi
Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases. These types of interactions are usually characterized by a specific binding motif that captures the key amino acids shared among the interaction partners. However, the computational proteome-level identification of interaction partners based on the known motif is hindered by the huge number of randomly occurring matches from which biologically relevant motif hits need to be extracted...
December 14, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29240630/in-vitro-characterization-of-the-pittsburgh-pediatric-ambulatory-lung
#3
Ryan A Orizondo, Alexandra G May, Shalv P Madhani, Brian J Frankowski, Greg W Burgreen, Peter D Wearden, William J Federspiel
Acute and chronic respiratory failure are a significant source of pediatric morbidity and mortality. Current respiratory support options used to bridge children to lung recovery or transplantation typically render them bedridden and can worsen long-term patient outcomes. The Pittsburgh Pediatric Ambulatory Lung (P-PAL) is a wearable pediatric blood pump and oxygenator (0.3 m surface area) integrated into a single compact unit that enables patient ambulation. The P-PAL is intended for long-term use and designed to provide up to 90% of respiratory support in children weighing 5-25 kg...
December 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29240263/cytochemical-flow-analysis-of-intracellular-g6pd-and-aggregate-analysis-of-mosaic-g6pd-expression
#4
Michael Kalnoky, Germana Bancone, Maria Kahn, Cindy S Chu, Nongnud Chowwiwat, Pornpimon Wilaisrisak, Sampa Pal, Nicole LaRue, Brandon Leader, Francois Nosten, Gonzalo J Domingo
BACKGROUND: Medicines that exert oxidative pressure on red blood cells (RBC) can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Due to X-chromosome inactivation, females heterozygous for G6PD with one allele encoding a G6PD deficient protein and the other a normal protein produce two RBC populations each expressing exclusively one allele. The G6PD mosaic is not captured with routine G6PD tests. METHODS: An open-source software tool for G6PD cytofluorometric data interpretation is described...
December 14, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29239716/pseudomonas-fluvialis-sp-nov-a-novel-member-of-the-genus-pseudomonas-isolated-from-the-river-ganges-india
#5
Sarabjeet Kour Sudan, Deepika Pal, Bhawana Bisht, Narender Kumar, Vasvi Chaudhry, Prabhu Patil, Girish Sahni, Shanmugam Mayilraj, Srinivasan Krishnamurthi
A bacterial strain, designated ASS-1T, was isolated and identified from a sediment sample of the river Ganges, Allahabad, India. The strain was Gram-stain-negative, formed straw-yellow pigmented colonies, was strictly aerobic, motile with a single polar flagellum, and positive for oxidase and catalase. The major fatty acids were C16 : 1ω7c/ 16 : 1 C16 : 1ω6c, C18 : 1ω7c and C16 : 0. Sequence analysis based on the 16S rRNA gene revealed that strain ASS-1T showed high similarity to Pseudomonas guguanensis CC-G9AT (98...
December 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29239082/utility-of-early-transperineal-template-guided-prostate-biopsy-for-risk-stratification-in-men-undergoing-active-surveillance-for-prostate-cancer
#6
James Voss, Raj Pal, Shaista Ahmed, Magnus Hannah, Adil Jaulim, Thomas Walton
OBJECTIVE: To assess the accuracy and utility of routine multiparametric MRI (mp-MRI) and transperineal template-guided prostate biopsy (TPB) following enrolment on to active surveillance. PATIENTS AND METHODS: From April 2012 to December 2016 consecutive men from our single institution diagnosed with low or intermediate risk prostate cancer on TRUS biopsy were offered further staging with early mp-MRI and TPB within 12 months of diagnosis. Data was collected prospectively...
December 14, 2017: BJU International
https://www.readbyqxmd.com/read/29238688/second-branchial-anomalies-a-study-of-94-cases
#7
Vijay Kumar Kalra, Kamal Nain Rattan, Samar Pal Singh Yadav, Sandeep Bhukar, S Dheeraj
Ninety-four patients with second branchial anomalies were retrospectively analysed at a tertiary care centre from January 2006 to September 2016 to determine the demographical data and management. Branchial sinus and fistula presented earlier as compared to branchial cyst. The mean age at presentation in case of branchial sinuses, fistulae and cysts was 5.07, 5.79 and 7.31 years respectively. There was preponderance in males as compared to females, more so in bilateral cases. Male to female sex ratio was 2...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29237863/correction-to-a-phosphorus-threshold-for-mycoheterotrophic-plants-in-tropical-forests
#8
Merlin Sheldrake, Nicholas P Rosenstock, Daniel Revillini, Pål Axel Olsson, S Joseph Wright, Benjamin L Turner
No abstract text is available yet for this article.
December 20, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29236986/training-in-cardiac-computed-tomography-eacvi-certification-process
#9
Gianluca Pontone, Sarah Moharem-Elgamal, Pal Maurovich-Horvat, Oliver Gaemperli, Francesca Pugliese, Mark Westwood, Alexandros Stefanidis, Kevin F Fox, Bogdan A Popescu
No abstract text is available yet for this article.
December 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29234458/robust-genetic-transformation-of-sorghum-sorghum-bicolor-l-using-differentiating-embryogenic-callus-induced-from-immature-embryos
#10
Srinivas Belide, Thomas Vanhercke, James Robertson Petrie, Surinder Pal Singh
Background: Sorghum (Sorghum bicolor L.) is one of the world's most important cereal crops grown for multiple applications and has been identified as a potential biofuel crop. Despite several decades of study, sorghum has been widely considered as a recalcitrant major crop for transformation due to accumulation of phenolic compounds, lack of model genotypes, low regeneration frequency and loss of regeneration potential through sub-cultures. Among different explants used for genetic transformation of sorghum, immature embryos are ideal over other explants...
2017: Plant Methods
https://www.readbyqxmd.com/read/29234070/dielectric-barrier-discharge-based-mercury-free-plasma-uv-lamp-for-efficient-water-disinfection
#11
Ram Prakash, Afaque M Hossain, U N Pal, N Kumar, K Khairnar, M Krishna Mohan
A structurally simple dielectric barrier discharge based mercury-free plasma UV-light source has been developed for efficient water disinfection. The source comprises of a dielectric barrier discharge arrangement between two co-axial quartz tubes with an optimized gas gap. The outer electrode is an aluminium baked foil tape arranged in a helical form with optimized pitch, while the inner electrode is a hollow aluminium metallic rod, hermetically sealed. Strong bands peaking at wavelengths 172 nm and 253 nm, along with a weak band peaking at wavelength 265 nm have been simultaneously observed due to plasma radiation from the admixture of xenon and iodine gases...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234015/high-resolution-single-particle-zeta-potential-characterisation-of-biological-nanoparticles-using-tunable-resistive-pulse-sensing
#12
Robert Vogel, Anoop K Pal, Siddharth Jambhrunkar, Pragnesh Patel, Sachin S Thakur, Eduardo Reátegui, Harendra S Parekh, Paula Saá, Adonis Stassinopoulos, Murray F Broom
Physicochemical properties of nanoparticles, such as size, shape, surface charge, density, and porosity play a central role in biological interactions and hence accurate determination of these characteristics is of utmost importance. Here we propose tunable resistive pulse sensing for simultaneous size and surface charge measurements on a particle-by-particle basis, enabling the analysis of a wide spectrum of nanoparticles and their mixtures. Existing methodologies for measuring zeta potential of nanoparticles using resistive pulse sensing are significantly improved by including convection into the theoretical model...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233836/radiomic-features-are-superior-to-conventional-quantitative-computed-tomographic-metrics-to-identify-coronary-plaques-with-napkin-ring-sign
#13
Márton Kolossváry, Júlia Karády, Bálint Szilveszter, Pieter Kitslaar, Udo Hoffmann, Béla Merkely, Pál Maurovich-Horvat
BACKGROUND: Napkin-ring sign (NRS) is an independent prognostic imaging marker of major adverse cardiac events. However, identification of NRS is challenging because of its qualitative nature. Radiomics is the process of extracting thousands of quantitative parameters from medical images to create big-data data sets that can identify distinct patterns in radiological images. Therefore, we sought to determine whether radiomic analysis improves the identification of NRS plaques. METHODS AND RESULTS: From 2674 patients referred to coronary computed tomographic angiography caused by stable chest pain, expert readers identified 30 patients with NRS plaques and matched these with 30 non-NRS plaques with similar degree of calcification, luminal obstruction, localization, and imaging parameters...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29233632/rationale-and-design-of-the-worldwide-prospective-multicenter-registry-on-radiation-dose-estimates-of-cardiac-ct-angiography-in-daily-practice-in-2017-protection-vi
#14
Thomas J Stocker, Simon Deseive, Marcus Chen, Jonathon Leipsic, Martin Hadamitzky, Ronen Rubinshtein, Erik L Grove, Xiang-Ming Fang, John Lesser, Pál Maurovich-Horvat, Hugo Marques, Daniele Andreini, Ramzi Tabbalat, Joon-Won Kang, Joachim Eckert, Patricia Dickson, Signe H Forsdahl, Jess Lambrechtsen, Roberto C Cury, Jörg Hausleiter
BACKGROUND: Cardiac computed tomography angiography (cardiac CTA) is an increasingly used versatile imaging method to evaluate coronary and cardiac morphology. Owing to improvements in technology, image quality has continuously improved over the last 10-20 years. At the same time, numerous non-randomized and randomized studies have been performed to reduce the associated radiation exposure. Currently, it is unclear if the advances in technology and knowledge about radiation reduction translated into reduced levels of cardiac CTA radiation dose in daily clinical practice as well as a wide utilization of dose-saving strategies...
December 5, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29233499/the-role-of-the-carboxyl-ester-lipase-cel-gene-in-pancreatic-disease
#15
REVIEW
Bente B Johansson, Karianne Fjeld, Khadija El Jellas, Anny Gravdal, Monica Dalva, Erling Tjora, Helge Ræder, Rohit N Kulkarni, Stefan Johansson, Pål R Njølstad, Anders Molven
The enzyme carboxyl ester lipase (CEL), also known as bile salt-dependent or -stimulated lipase (BSDL, BSSL), hydrolyzes dietary fat, cholesteryl esters and fat-soluble vitamins in the duodenum. CEL is mainly expressed in pancreatic acinar cells and lactating mammary glands. The human CEL gene resides on chromosome 9q34.3 and contains a variable number of tandem repeats (VNTR) region that encodes a mucin-like protein tail. Although the number of normal repeats does not appear to significantly influence the risk for pancreatic disease, single-base pair deletions in the first VNTR repeat cause a syndrome of endocrine and exocrine dysfunction denoted MODY8...
December 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29233388/peer-teaching-as-an-educational-tool-in-pharmacy-schools-fruitful-or-futile
#16
REVIEW
Mona Hassan Aburahma, Heba Moustafa Mohamed
BACKGROUND: In the past decade, various health care programs have implemented diverse types of peer-assisted learning (PAL) programs, in particularly peer teaching (PT), due to their reported benefits for students (both those undertaking teaching and those being taught), teachers, and educational institutes. Unfortunately, peer teaching is still under-recognized in pharmacy programs worldwide when compared to other health care programs. The aim of this review is to provide an overview of the published literature centered on formal PT programs that are implemented in pharmacy schools...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29232285/cyclophosphamide-induced-hearing-loss-reversibility-and-preventive-strategies
#17
Ankita Tuknayat, Gurvinder Pal Thami, Pragati Gogia, Mohit Bhutani
No abstract text is available yet for this article.
November 22, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29229886/criticality-in-cell-differentiation
#18
Indrani Bose, Mainak Pal
Cell differentiation is an important process in living organisms. Differentiation is mostly based on binary decisions with the progenitor cells choosing between two specific lineages. The differentiation dynamics have both deterministic and stochastic components. Several theoretical studies suggest that cell differentiation is a bifurcation phenomenon, well-known in dynamical systems theory. The bifurcation point has the character of a critical point with the system dynamics exhibiting specific features in its vicinity...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29229201/recent-advances-in-degradation-of-chloronitrophenols
#19
REVIEW
Pankaj Kumar Arora, Alok Srivastava, Sanjay Kumar Garg, Vijai Pal Singh
Chloronitrophenols (CNPs) constitute a group of environmental pollutants that are widely distributed in our surrounding environment due to human based activities. This group of chemicals is highly toxic to living beings due to its mutagenic and carcinogenic nature. Examples include 2-chloro-4-nitrophenol, 4-chloro-2-nitrophenol, 2-chloro-5-nitrophenol, 4-chloro-3-nitrophenol and 2,6-dichloro-4-nitrophenol. Several methods including advanced oxidation processes, adsorption and bacterial degradation have been used for degradation of CNPs...
December 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29229010/relative-importance-of-phosphatidylinositol-3-kinase-pi3k-akt-and-mitogen-activated-protein-kinase-mapk3-1-signaling-during-maturational-steroid-induced-meiotic-g2-m1-transition-in-zebrafish-oocytes
#20
Debabrata Das, Poulomi Nath, Soumojit Pal, Sudip Hajra, Pritha Ghosh, Sudipta Maitra
Participation and relative importance of phosphatidylinositol-3 kinase (PI3K) and mitogen-activated protein kinase (MAPK) signalling, either alone or in combination, have been investigated during 17α,20β-dihydroxy-4-pregnen-3-one (DHP)-induced meiotic G2-M1 transition in denuded zebrafish oocyte. Results demonstrate that concomitant with rapid phosphorylation (activation) of Akt (Ser473) and MAPK (ERK1/2) at as early as 15 min of incubation, DHP stimulation promotes enhanced an GVBD response and histone H1 kinase activation between 1 and 5 h in full-grown oocytes in vitro...
December 12, 2017: Zygote: the Biology of Gametes and Early Embryos
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