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https://www.readbyqxmd.com/read/29676939/diffusion-kurtosis-imaging-in-the-differential-diagnosis-of-parotid-gland-disease-and-parotid-adenolymphoma-preliminary-results
#1
Shun Yu, Zhongshuai Zhang, Bao Qiang, S U Jiawei, Mengxiao Liu, Qinglei Shi, Wenchao Cai
PURPOSE: To study the value of diffusion kurtosis imaging (DKI) in diagnosis of parotid gland disease (PGD) with different pathological patterns and parotid adenolymphoma (PAL). METHODS: Fifty-seven patients with different kinds of PGD were enrolled and underwent DKI and conventional diffusion-weighted imaging (DWI). All patients were categorized into different groups according to their pathological patterns. The result of calculating the value of DKI-derived parameters (Kmean, Krad, Kax, Dmean, Drad, Dax, and FA) and apparent diffusion coefficient (ADC) of DWI were used to study their diagnostic accuracy in PGD with different pathological patterns...
April 20, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29676425/mechanistic-insights-into-the-interaction-between-energetic-oxygen-ions-and-nanosized-znfe-2-o-4-xas-xmcd-investigations
#2
Jitendra Pal Singh, Baljeet Kaur, Aditya Sharma, So Hee Kim, Sanjeev Gautam, Ramesh Chandra Srivastava, Navdeep Goyal, Weol Cheol Lim, H-J Lin, J M Chen, K Asokan, D Kanjilal, Sung Ok Won, Ik-Jae Lee, Keun Hwa Chae
The interactions of energetic ions with multi-cation compounds and their consequences in terms of changes in the local electronic structure, which may facilitate intriguing hybridization between O 2p and metal d orbitals and magnetic ordering, are the subject of debate and require a deep understanding of energy transfer processes and magnetic exchange mechanisms. In this study, nanocrystals of ZnFe2O4 were exposed to O7+ ions with an energy of 100 MeV to understand, qualitatively and quantitatively, the metal-ligand field interactions, cation migration and magnetic exchange interactions by employing X-ray absorption fine structure measurements and X-ray magnetic circular dichroism to get deeper mechanistic insights...
April 20, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29675151/enantioselective-cellular-localisation-of-europium-iii-coordination-complexes
#3
Andrew T Frawley, Holly V Linford, Matthieu Starck, Robert Pal, David Parker
The selective mitochondrial localisation of the Λ enantiomer of three different emissive europium(iii) complexes in NIH 3T3 and MCF7 cells contrasts with the behaviour of the Δ enantiomer, for which a predominant lysosomal localisation was observed by confocal microscopy. In each case, cell uptake occurs via macropinocytosis.
January 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675031/exogenous-melatonin-application-delays-senescence-of-kiwifruit-leaves-by-regulating-the-antioxidant-capacity-and-biosynthesis-of-flavonoids
#4
Dong Liang, Yanqiu Shen, Zhiyou Ni, Qin Wang, Zhi Lei, Nengqin Xu, Qunxian Deng, Lijin Lin, Jin Wang, Xiulan Lv, Hui Xia
Melatonin, a multiple signal molecule, plays important roles in delaying senescence during the development of plants. Because few species have been studied for the effect of exogenous melatonin on anti-aging, the plausible mechanism of melatonin of anti-aging effects on other plant species has remained largely unknown. In the present study, the effects of exogenous melatonin on leaf senescence in kiwifruit were examined during natural aging after melatonin (200 μM) or water (Control) pretreatment. The decreased membrane damage and lower hydrogen peroxide (H2 O2 ) content due to the enhanced scavenging activity of antioxidant enzymes peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) demonstrated that melatonin effectively delayed the aging of kiwifruit leaves...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29674987/the-complex-interplay-between-depression-anxiety-and-executive-functioning-insights-from-the-ecas-in-a-large-als-population
#5
Laura Carelli, Federica Solca, Andrea Faini, Fabiana Madotto, Annalisa Lafronza, Alessia Monti, Stefano Zago, Alberto Doretti, Andrea Ciammola, Nicola Ticozzi, Vincenzo Silani, Barbara Poletti
Introduction: The observed association between depressive symptoms and cognitive performances has not been previously clarified in patients with amyotrophic lateral sclerosis (pALS). In fact, the use of cognitive measures often not accommodating for motor disability has led to heterogeneous and not conclusive findings about this issue. The aim of the present study was to evaluate the relationship between cognitive and depressive/anxiety symptoms by means of the recently developed Edinburgh Cognitive and Behavioral ALS Screen (ECAS), a brief assessment specifically designed for pALS...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674707/targeted-genomic-landscape-of-metastases-compared-to-primary-tumours-in-clear-cell-metastatic-renal-cell-carcinoma
#6
Guillermo de Velasco, Stephanie A Wankowicz, Russell Madison, Siraj M Ali, Craig Norton, Audrey Duquette, Jeffrey S Ross, Dominick Bossé, Aly-Khan A Lalani, Vincent A Miller, Philip J Stephens, Lauren Young, A Ari Hakimi, Sabina Signoretti, Sumanta K Pal, Toni K Choueiri
BACKGROUND: The genomic landscape of primary clear cell renal cell carcinoma (ccRCC) has been well described. However, little is known about cohort genomic alterations (GA) landscape in ccRCC metastases, or how it compares to primary tumours in aggregate. The genomic landscape of metastases may have biological, clinical, and therapeutic implications. METHODS: We collected targeted next-generation sequencing mutation calls from two independent cohorts and described the metastases GA landscape and descriptively compared it to the GA landscape in primary tumours...
April 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29674112/cadherin-profiling-for-therapeutic-interventions-in-epithelial-mesenchymal-transition-emt-and-tumorigenesis
#7
REVIEW
Mintu Pal, Sourya Bhattacharya, Gazal Kalyan, Saugata Hazra
The major hallmarks of Epithelial-Mesenchymal Transition (EMT) is the loss of epithelial cell polarity and loss of expression of the cell- cell adhesion molecule like E-cadherin and acquired mesenchymal cells marker called N-Cadherin. This phenotypical changes of E-M plasticity of cells is extensively considered to be a crucial factor for tumor cells invasion and cancer metastasis; landmark events for transforming a locally growing tumor (benign tumor) into a systemic and live-threatening disease (malignant tumor)...
April 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29672961/baicalin-is-a-substrate-of-oatp2b1-and-oatp1b3
#8
Bernadett Kalapos-Kovács, Viktória Juhász, Csilla Temesszentandrási-Ambrus, Balázs Magda, Pál T Szabó, István Antal, Imre Klebovich, Péter Krajcsi
No abstract text is available yet for this article.
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29672374/integrating-team-training-in-the-pediatric-life-support-program-an-effective-and-efficient-approach
#9
Mary J Fagan, Cynthia D Connelly, Brian S Williams, Erin Stucky Fisher
OBJECTIVE: The aim of this study was to examine the feasibility of integrating teamwork training into an established Pediatric Advanced Life Support (PALS) program to assess the effect on teamwork and collaboration among interprofessionals. BACKGROUND: Lack of teamwork and ineffective communication are common contributors to hospital sentinel events. Interprofessional teamwork training to support a culture of patient safety is advocated; however, training methods and related expenses vary widely...
May 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29671589/linear-mgcp-2-vs-bent-cacp-2-london-dispersion-ligand-induced-charge-localizations-and-pseudo-pregostic-c-h%C3%A2-%C3%A2-%C3%A2-ca-interactions
#10
Rumpa Pal, Stefan Mebs, Ming W Shi, Dylan Jayatilaka, Joanna M Krzeszczakowska, Lorraine A Malaspina, Michal Wiecko, Peter Luger, Malte Hesse, Yu-Sheng Chen, Jens Beckmann, Simon Grabowsky
In the family of metallocenes, MgCp*2 (Cp* = pentamethylcyclopentadienyl) exhibits a regular linear sandwich structure, whereas CaCp*2 is bent in both the gas phase and solid state. Bending is typically observed for metal ions which possess a lone pair. Here, we investigate which electronic differences cause the bending in complexes lacking lone pairs at the metal atoms. The bent gas-phase geometry of CaCp*2 suggests that the bending must have an intramolecular origin. Geometry optimizations with and without dispersion effects/d-type polarization functions on MCp2 and MCp*2 gas-phase complexes (M = Ca, Mg) establish that attractive methyl···methyl London dispersion interactions play a decisive role in the bending in CaCp*2 ...
April 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29670624/photochemical-internalization-of-peptide-antigens-provides-a-novel-strategy-to-realize-therapeutic-cancer-vaccination
#11
Markus Haug, Gaute Brede, Monika Håkerud, Anne Grete Nedberg, Odrun A Gederaas, Trude H Flo, Victoria T Edwards, Pål K Selbo, Anders Høgset, Øyvind Halaas
Effective priming and activation of tumor-specific CD8+ cytotoxic T lymphocytes (CTLs) is crucial for realizing the potential of therapeutic cancer vaccination. This requires cytosolic antigens that feed into the MHC class I presentation pathway, which is not efficiently achieved with most current vaccination technologies. Photochemical internalization (PCI) provides an emerging technology to route endocytosed material to the cytosol of cells, based on light-induced disruption of endosomal membranes using a photosensitizing compound...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670556/emotional-dissonance-and-sickness-absence-among-employees-working-with-customers-and-clients-a-moderated-mediation-model-via-exhaustion-and-human-resource-primacy
#12
Anne-Marthe R Indregard, Pål Ulleberg, Stein Knardahl, Morten B Nielsen
Emotional dissonance, i.e., a discrepancy between required and felt emotions, has been established as a predictor of sickness absence in studies, but little is known about mechanisms that can explain this association. In order to prevent and reduce the impact of emotional dissonance on sickness absence, there is a need for greater attention to variables explaining when and how emotional dissonance is related to sickness absence. The overarching aim of this study was to examine whether emotional dissonance has an indirect association with sickness absence through exhaustion...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29667754/estrogen-regulated-expression-of-p450arom-genes-in-the-brain-and-ovaries-of-adult-female-indian-climbing-perch-anabas-testudineus
#13
Puja Pal, Sujata Roy Moulik, Shreyasi Gupta, Payel Guha, Suravi Majumder, Sourav Kundu, Buddhadev Mallick, Kousik Pramanick, Dilip Mukherjee
Cytochrome P450arom (CYP19), a product of cyp19a1 gene, catalyzes the conversion of androgens to estrogens and is essential for regulation of reproductive function in vertebrates. In the present study, we isolated partial cDNA encoding the ovarian (cyp19a1a) and brain (cyp19a1b) P450arom genes from adult female perch, Anabas testudineus and investigated their regulation by estrogen in vivo. Results demonstrated that cyp19a1a and cyp19a1b predominate in ovary and brain respectively, with quantity of both attuned to reproductive cycle...
April 18, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29667108/5-hydroxytryptamine-receptor-6-antagonist-sb258585-exerts-neuroprotection-in-a-rat-model-of-streptozotocin-induced-alzheimer-s-disease
#14
Nasrin Hashemi-Firouzi, Siamak Shahidi, Sara Soleimani-Asl, Alireza Komaki
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory decline. It has been suggested that 5-hydroxytryptamine receptor 6 (5-HT6R) might be involved in AD pathology. The aim of this study was to evaluate the effect of a 5-HT6R antagonist on cognition, learning, memory, and hippocampal apoptosis in an experimental rat model of AD. AD was induced by intracerebroventricular (icv) administration of streptozotocin (STZ; 3 mg/kg, 10 μL, twice). Adult, male rats were divided into the following groups: control, sham, AD (saline treatment, 1 μL icv for 30 days), and AD + SB258585 (5-HT6R antagonist, 1 μg/μL icv for 30 days)...
April 17, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29666977/candidate-genes-of-flavonoid-biosynthesis-in-selaginella-bryopteris-l-baker-identified-by-rna-seq
#15
Ravi S Singh, Ravi Kesari, Ujjwal Kumar, Vikash Kumar Jha, Anjani Kumar, Tribhuwan Kumar, Awadhesh K Pal, Prabhash K Singh
In the present study, de novo transcriptome analysis of Selaginella bryopteris in frond and root was performed to understand the regulation of flavonoid (FL) biosynthesis. High-quality data of 5.84 and 5.86 Gb was generated for frond and root, respectively, that assembled into 94,713 and 81,567 transcripts. A total of 87,471 and 73,395 unigenes were obtained from frond and root, respectively. A total of 41,267 and 31,048 CDS of frond and root, respectively, were annotated by BLASTX, which showed maximum hits against S...
April 18, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29666708/nonphotodynamic-roles-of-methylene-blue-display-of-distinct-antimycobacterial-and-anticandidal-mode-of-actions
#16
Rahul Pal, Moiz A Ansari, Venkata Saibabu, Shrayanee Das, Zeeshan Fatima, Saif Hameed
Significance of methylene blue (MB) in photodynamic therapy against microbes is well established. Previously, we have reported the antifungal potential of MB against Candida albicans . The present study attempts to identify additional antimicrobial effect of MB against another prevalent human pathogen, Mycobacterium tuberculosis (MTB). We explored that MB is efficiently inhibiting the growth of Mycobacterium at 15.62  μ g/ml albeit in bacteriostatic manner similar to its fungistatic nature. We uncovered additional cell surface phenotypes (colony morphology and cell sedimentation rate) which were impaired only in Mycobacterium ...
2018: Journal of Pathogens
https://www.readbyqxmd.com/read/29666619/deletion-of-a-gene-encoding-a-putative-peptidoglycan-associated-lipoprotein-prevents-degradation-of-the-crystalline-region-of-cellulose-in-cytophaga-hutchinsonii
#17
Xifeng Wang, Zhiquan Wang, Xinfeng Bai, Yue Zhao, Weican Zhang, Xuemei Lu
Cytophaga hutchinsonii is a gliding Gram-negative bacterium in the phylum Bacteroidetes with the capability to digest crystalline cellulose rapidly, but the mechanism is unclear. In this study, deletion of chu_0125 , encoding a homolog of the peptidoglycan-associated lipoprotein (Pal), was determined to prevent degradation of the crystalline region of cellulose. We found that the chu_0125 deletion mutant grew normally in regenerated amorphous cellulose medium but displayed defective growth in crystalline cellulose medium and increased the degree of crystallinity of Avicel...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29666560/storage-stability-of-commonly-used-haematological-parameters-at-33-%C3%A2-c-electronic-supplementary-material-available-online-for-this-article
#18
Ashish Jain, Sanchit Jain, Neha Singh, Priyanka Aswal, Shweta Pal, Sushant Kumar Meinia, Nilotpal Chowdhury
Introduction: This study aimed to investigate the analytical bias in haematological parameters induced by storage at 33 ºC. Materials and methods: Blood from the diversion pouch of 20 blood donors were collected in K 2 EDTA vials and stored at 33 ºC. Readings from each vial were taken at 0, 4, 6, 12, 24, 48 and 72 hours after collection on the Sysmex XP-100 analyser (Sysmex Corporation, Kobe, Japan). The percent difference from the baseline readings were calculated and subjected to a Wilcoxon signed rank test at a Holm corrected significance level of 0...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29666533/purple-head-broccoli-brassica-oleracea-l-var-italica-plenck-a-functional-food-crop-for-antioxidant-and-anticancer-potential
#19
Ashun Chaudhary, Sonika Choudhary, Upendra Sharma, Adarsh Pal Vig, Bikram Singh, Saroj Arora
Natural foods are used in many folks and household treatments and have immense potential to treat a serious complication and health benefits, in addition to the basic nutritional values. These food products improve health, delay the aging process, increase life expectancy, and possibly prevent chronic diseases. Purple head Brassica oleracea L. var. italica Plenck is one of such foods and in current studies was explored for chemical compounds at different development stages by gas chromatography-mass spectrometry...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666341/genetic-testing-for-clinically-suspected-spinocerebellar-ataxias-report-from-a-tertiary-referral-centre-in-india
#20
Sowmya Devatha Venkatesh, Mahesh Kandasamy, Nagaraj S Moily, Radhika Vaidyanathan, Lakshmi Narayanan Kota, Syama Adhikarla, Ravi Yadav, Pramod Kumar Pal, Sanjeev Jain, Meera Purushottam
Spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative syndromes, characterized by a wide range of muscular weakness and motor deficits, caused due to cerebellar degeneration. The prevalence of the syndromes of SCA varies across the world and is known to be linked to the instability of trinucleotide repeats within the high-end normal alleles, along with susceptible haplotype. We estimated sizes of the CAG or GAA repeat expansions at the SCA1, SCA2, SCA3, SCA12 and frataxin loci among 864 referrals of subjects to genetic counselling and testing (GCAT) clinic, National Institute of Mental Health and Neurosciences, Bengaluru, India, with suspected SCA...
March 2018: Journal of Genetics
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