keyword
MENU ▼
Read by QxMD icon Read
search

Photoprotection

keyword
https://www.readbyqxmd.com/read/29156348/development-of-photoprotective-antiphototoxic-and-antiphotogenotoxic-formulations-of-ocular-drugs-with-fluoroquinolones
#1
Anna Zgadzaj, Joanna Kornacka, Anita Jastrzębska, Andrzej Parzonko, Sylwester Sommer, Grzegorz Nałęcz-Jawecki
The development of innovative solutions in photosafety of photolabile pharmaceutical products may help to reduce the adverse effects of these products, caused by light exposure. Providing new data in this area of study is particularly important in case of drugs applied topically on sensitive organs such as eyes. The main goal of this research is to investigate whether two potential excipients, namely: p-coumaric acid and benzophenone-4, affect the photodegradation, phototoxicity and photogenotoxicity of water solutions of four fluoroquinolones: ciprofloxacin, lomefloxacin, fleroxacin and clinafloxacin...
November 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29154200/uvr-and-par-absorbing-compounds-of-marine-brown-macroalgae-along-a-latitudinal-gradient-of-the-brazilian-coast
#2
Caroline Schmitz, Fernanda Ramlov, Leidson Allan Ferreira de Lucena, Virgilio Uarrota, Manuela Bernardes Batista, Marina Nasri Sissini, Iara Oliveira, Bruno Briani, Cintia D L Martins, José Marcos de Castro Nunes, Leonardo Rörig, Paulo Antunes Horta, Félix L Figueroa, Nathalie Korbee, Marcelo Maraschin, José Bonomi-Barufi
Absorption spectra are indicative of biological sample chemical composition and can be used as a basis for the construction of descriptive and predictive models for biotechnological screening or assays. In marine algae, chemical composition can vary due to species-specific differences in biochemistry, as well as intra-specific responses to unique environmental variables. Different indices (UVCi, UVB+Ai and PARi) were proposed and calculated to evaluate how photoprotective compounds vary in 18 species of Phaeophyceae...
October 31, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29152226/an-overview-of-the-cutaneous-porphyrias
#3
REVIEW
Robert Dawe
This is an overview of the cutaneous porphyrias. It is a narrative review based on the published literature and my personal experience; it is not based on a formal systematic search of the literature. The cutaneous porphyrias are a diverse group of conditions due to inherited or acquired enzyme defects in the porphyrin-haem biosynthetic pathway. All the cutaneous porphyrias can have (either as a consequence of the porphyria or as part of the cause of the porphyria) involvement of other organs as well as the skin...
2017: F1000Research
https://www.readbyqxmd.com/read/29146776/light-signaling-dependent-regulation-of-photoinhibition-and-photoprotection-in-tomato
#4
Feng Wang, Nan Wu, Luyue Zhang, Golam Jalal Ahammed, Xiaoxiao Chen, Xun Xiang, Jie Zhou, Xiaojian Xia, Kai Shi, Jingquan Yu, Christine H Foyer, Yanhong Zhou
Photoreceptor-mediated light signaling plays a critical role in plant growth, development, and stress responses but its contribution to the spatial regulation of photoinhibition and photoprotection within the canopy remains unclear. Here, we show that low red/far-red (L-R/FR) ratio light conditions significantly alleviate PSII and PSI photoinhibition in the shade leaves of tomato plants. This protection is accompanied by a phytochrome A (phyA)-dependent induction of LONG HYPOCOTYL 5 (HY5). HY5 binds to the promoter of ABA INSENSITIVE 5 (ABI5), triggering RESPIRATORY BURST OXIDASE HOMOLOG1 (RBOH1)-dependent H2O2 production in the apoplast...
November 16, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29146147/age-induced-and-photoinduced-changes-in-gene-expression-profiles-in-facial-skin-of-caucasian-females-across-6%C3%A2-decades-of-age
#5
Alexa B Kimball, Maria B Alora-Palli, Makio Tamura, Lisa A Mullins, Chieko Soh, Robert L Binder, Neil A Houston, Emily D Conley, Joyce Y Tung, Nikki E Annunziata, Charles C Bascom, Robert J Isfort, Bradley B Jarrold, Raghu Kainkaryam, Heather L Rocchetta, Dionne D Swift, Jay P Tiesman, Kazumi Toyama, Jun Xu, Xianghong Yan, Rosemarie Osborne
BACKGROUND: Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging. OBJECTIVE: We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age. METHODS: Histologic and transcriptomics profiling were conducted on skin biopsy samples of photoexposed (face and dorsal forearm) or photoprotected (buttocks) body sites from 158 women...
November 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29138423/the-photocycle-of-orange-carotenoid-protein-conceals-distinct-intermediates-and-asynchronous-changes-in-the-carotenoid-and-protein-components
#6
E G Maksimov, N N Sluchanko, Y B Slonimskiy, E A Slutskaya, A V Stepanov, A M Argentova-Stevens, E A Shirshin, G V Tsoraev, K E Klementiev, O V Slatinskaya, E P Lukashev, T Friedrich, V Z Paschenko, A B Rubin
The 35-kDa Orange Carotenoid Protein (OCP) is responsible for photoprotection in cyanobacteria. It acts as a light intensity sensor and efficient quencher of phycobilisome excitation. Photoactivation triggers large-scale conformational rearrangements to convert OCP from the orange OCP(O) state to the red active signaling state, OCP(R), as demonstrated by various structural methods. Such rearrangements imply a complete, yet reversible separation of structural domains and translocation of the carotenoid. Recently, dynamic crystallography of OCP(O) suggested the existence of photocycle intermediates with small-scale rearrangements that may trigger further transitions...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29131317/molecular-photoprotection-of-human-keratinocytes-in-vitro-by-the-naturally-occurring-mycosporine-like-amino-acid-maa-palythine
#7
K P Lawrence, R Gacesa, P F Long, A R Young
BACKGROUND: Solar ultraviolet radiation (UVR) induces molecular and genetic changes in the skin, which result in skin cancer, photoageing and photosensitivity disorders. The use of sunscreens is advocated to prevent such photodamage, however most formulations contain synthetic UVR filters that are non-biodegradable and can damage fragile marine ecosystems. Mycosporine-like amino acids (MAA) are natural UVR-absorbing compounds that have evolved in marine species for protection against chronic UVR exposure in shallow-water habitats...
November 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29129045/development-of-s-methylmethionine-sulfonium-derivatives-and-their-skin-protective-effect-against-ultraviolet-exposure
#8
Won-Serk Kim, Wang-Kyun Kim, Nahyun Choi, Wonhee Suh, Jinu Lee, Dae-Duk Kim, Ikyon Kim, Jong-Hyuk Sung
In a previous study, we have demonstrated that S-methylmethionine sulfonium (SMMS) confers wound-healing and photoprotective effects on the skin, suggesting that SMMS can be used as a cosmetic raw material. However, it has an unpleasant odor. Therefore, in the present study, we synthesized odor-free SMMS derivatives by eliminating dimethyl sulfide, which is the cause of the unpleasant odor and identified two derivatives that exhibited skin-protective effects: one derivative comprised (2S,4S)- and (2R,4S)-2-phenylthiazolidine-4-carboxylic acid and the other comprised (2S,4R)-, (2S,4S)-, (2R,4R)-, and (2R,4S)-2-phenyl-1,3-thiazinane-4-carboxylic acid...
November 13, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29124695/photodermatoses-in-the-pigmented-skin
#9
Vinod Kumar Sharma, Kanika Sahni
Skin colour (specifically in relation to its melanin content and composition) has a marked influence on its interaction with ultraviolet light. Eumelanin has mainly photoprotective properties while pheomelanin has the ability to cause formation of reactive oxygen species. This difference is responsible for the difference in incidence and presentation of various idiopathic photodermatoses in dark skinned patients compared to those with lighter skin types. Certain conditions are peculiar to darker skins including pin point popular variant of polymorphous light eruption...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29124693/ultraviolet-photobiology-in-dermatology
#10
Luisa Christensen, Amanda Suggs, Elma Baron
The effects of ultraviolet radiation on human skin have been studied for years, and both its harmful and therapeutic effects are well known. Exposure to UV light can lead to sunburn, immunosuppression, skin aging, and carcinogenesis, and photoprotection is strongly advocated. However, when used under controlled conditions, UV radiation can also be helpful in the diagnosis and treatment of many skin conditions.
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29124692/ultraviolet-radiations-skin-defense-damage-mechanism
#11
Dheeraj Mohania, Shikha Chandel, Parveen Kumar, Vivek Verma, Kumar Digvijay, Deepika Tripathi, Khushboo Choudhury, Sandeep Kumar Mitten, Dilip Shah
UV-radiations are the invisible part of light spectra having a wavelength between visible rays and X-rays. Based on wavelength, UV rays are subdivided into UV-A (320-400 nm), UV-B (280-320 nm) and UV-C (200-280 nm). Ultraviolet rays can have both harmful and beneficial effects. UV-C has the property of ionization thus acting as a strong mutagen, which can cause immune-mediated disease and cancer in adverse cases. Numbers of genetic factors have been identified in human involved in inducing skin cancer from UV-radiations...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29124118/chemical-analysis-and-evaluation-of-antioxidant-antimicrobial-and-photoprotective-activities-of-schinopsis-brasiliensis-engl-anacardiaceae
#12
Sarah Raquel Gomes de Lima-Saraiva, Fernanda Granja da Silva Oliveira, Raimundo Gonçalves de Oliveira Junior, Camila de Souza Araújo, Ana Paula de Oliveira, Alessandra Gomes Marques Pacheco, Larissa Araújo Rolim, Elba Lúcia Cavalcanti de Amorim, Francine Celise Siqueira César, Jackson Roberto Guedes da Silva Almeida
Schinopsis brasiliensis Engl. is a native plant of Caatinga which has high concentrations of compounds capable of absorbing ultraviolet light, suggesting its potential application for the development of sunscreen preparations. After its identification and collection, this vegetable drug was submitted to a physicochemical analysis through the preparation of ethanolic extract. The phytochemical screening and analysis of extracts were carried out by high-performance liquid chromatography (HPLC) evaluation. The antioxidant activity of the extract was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and β-carotene bleaching test...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/29123155/large-scale-in-vitro-production-refolding-and-dimerization-of-psbs-in-different-microenvironments
#13
Maithili Krishnan, Geri F Moolenaar, Karthick Babu Sai Sankar Gupta, Nora Goosen, Anjali Pandit
Plants adapt to fluctuating light conditions by a process called non-photochemical quenching (NPQ), where membrane protein PsbS plays a crucial role and transforms a change in the pH-gradient across the thylakoid membrane under excess light conditions into a photoprotective state, leading to de-excitation of antenna chlorophylls. The PsbS activation mechanism is elusive and has been proposed to involve a monomerization step and protonation of specific residues. To elucidate its function, it is essential to produce PsbS in large quantities, stabilize PsbS in a membrane-mimicking environment and analyze its pH-dependent conformational structure...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119916/cytoprotective-polyphenols-against-chronological-skin-aging-and-cutaneous-photodamage
#14
Sergio Davinelli, Juan Carlos Bertoglio, Ascanio Polimeni, Giovanni Scapagnini
BACKGROUND: Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations of skin structure, function and appearance. Polyphenols, which are secondary plant metabolites, represent one of the largest classes of compounds used in dermatology and nutricosmetics to combat skin aging. The main objective is to provide an overview of the existing literature linking skin aging and the ability of polyphenols as regulatory elements able to maintain skin homeostasis...
November 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29112891/a-novel-research-model-for-evaluating-sunscreen-protection-in-the-uv-a1
#15
Sônia Aparecida Figueiredo, Dayane Cristina de Moraes, Fernanda Maria Pinto Vilela, Amanda Natalina de Faria, Marcelo Henrique Dos Santos, Maria José Vieira Fonseca
The use of a broad spectrum sunscreen is considered one of the main and most popular measures for preventing the damaging effects of ultraviolet radiation (UVR) on the skin. In this study we have developed a novel in vitro method to assess sunscreens efficacy to protect calcineurin enzyme activity, a skin cell marker. The photoprotective efficacy of sunscreen products was assessed by measuring the UV-A1 radiation-induced depletion of calcineurin (Cn) enzyme activity in primary neonatal human dermal fibroblast (HDFn) cell lysates...
October 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29110298/long-term-genoprotection-effect-of-sechium-edule-fruit-extract-against-uva-irradiation-in-keratinocytes
#16
Elodie Metral, Walid Rachidi, Odile Damour, Frédéric Demarne, Nicolas Bechetoille
Photoprotection is essential to prevent the long-term deleterious effects of ultraviolet (UV), including skin cancer and photoaging. So far, there has been an increase in the use of natural bioactive phytochemicals for the development of more effective skin photoprotective agents. However, the molecular mechanisms underlying the photochemoprotection activity of such compounds remain largely unknown. The objective of this study was to investigate the effects of a Sechium edule fruit extract (SEE) in terms of photoprotection against UVA in primary human keratinocytes...
November 7, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29108541/cosmeceuticals-for-male-skin
#17
REVIEW
Zoe Diana Draelos
The male cosmeceutical market is still underdeveloped. Although women embrace skin care as a part of general health, this concept has not gained wide male acceptance. Shaving is probably the most beneficial daily grooming event men commonly undertake for skin appearance and may account for the failure of antiaging cosmeceuticals to attract attention in this segment. In addition, there are many physiologic differences between male and female skin, with less of a need for moisturization and photoprotection in men...
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29104718/topical-vitamin-c-and-the-skin-mechanisms-of-action-and-clinical-applications
#18
REVIEW
Firas Al-Niaimi, Nicole Yi Zhen Chiang
OBJECTIVE: This review article details the main mechanisms of action and clinical applications of topical vitamin C on the skin, including its antioxidative, photoprotective, antiaging, and antipigmentary effects. DESIGN: A PubMed search for the relevant articles on vitamin C and the skin was conducted using the following key words: "vitamin C," "ascorbic acid," "ascorbyl-6-palmitate,"and "magnesium ascorbyl phosphate." RESULTS: As one of the most powerful antioxidants in the skin, vitamin C has been shown to protect against photoaging, ultraviolet-induced immunosuppression, and photocarcinogenesis...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29103122/nitrogen-deposition-reduces-the-cover-of-biocrust-forming-lichens-and-soil-pigment-content-in-a-semiarid-mediterranean-shrubland
#19
Raúl Ochoa-Hueso, Tatiana Mondragon-Cortés, Laura Concostrina-Zubiri, Lilia Serrano-Grijalva, Belén Estébanez
Biocrusts are key drivers of the structure and functioning of drylands and are very sensitive to disturbance, including atmospheric nitrogen (N) deposition. We studied the impacts of simulated N deposition on biocrust community composition and soil photosynthetic and photoprotective pigment content after five years of N application in a European semiarid Mediterranean shrubland. The experiment consisted in six experimental blocks with four plots, each receiving 0, 10, 20, or 50 kg NH4NO3-N ha(-1) year(-1) + 6-7 kg N ha(-1) year(-1) background...
November 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29090371/cutaneous-manifestations-of-dermatomyositis-a-comprehensive-review
#20
REVIEW
Carlo Mainetti, Benedetta Terziroli Beretta-Piccoli, Carlo Selmi
Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by the presence of skin lesions and inflammation of skeletal muscles; however, this feature may be absent in amyopathic DM. DM is a rare disease, occurring at any age, and has two peaks of incidence: one in childhood between 5 and 15 years of age and one in adulthood between 40 and 60 years, with a female preponderance. DM has been associated with malignancy; therefore, every newly diagnosed patient should undergo screening investigations, but evidence-based guidelines on their extension are lacking...
October 31, 2017: Clinical Reviews in Allergy & Immunology
keyword
keyword
13408
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"