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endoscopic mucosal resection

Farzan F Bahin, Steven J Heitman, Michael J Bourke
No abstract text is available yet for this article.
May 19, 2018: Gut
Kavel Visrodia, Liam Zakko, Kenneth K Wang
The management of Barrett's esophagus and early esophageal adenocarcinoma has shifted away from esophagectomy and toward endoscopic techniques, including endoscopic resection and ablative therapies. The most commonly used ablative therapies are radiofrequency ablation and cryotherapy. Radiofrequency ablation has risen to the top of the management algorithm due to its favorable safety profile and established track record of efficacy in patients with dysplastic Barrett's. Cryotherapy offers early promise as an alternatively safe and effective ablative modality...
May 17, 2018: Digestive Diseases and Sciences
Sergio Cadoni, Mauro Liggi, Paolo Gallittu, Donatella Mura, Lorenzo Fuccio, Malcolm Koo, Sauid Ishaq
Background: Endoscopic mucosal resection is well-established for resecting flat or sessile benign colon polyps. The novel underwater endoscopic mucosal resection eschews submucosal injection prior to endoscopic mucosal resection. Reports about underwater endoscopic mucosal resection were limited to small series of single and/or tertiary-care referral centers, with single or supervised operators. Objective: The purpose of this study was to determine feasibility and efficacy of underwater resection of polyps of any morphology (underwater polypectomy, here includes underwater endoscopic mucosal resection) in routine clinical practice...
April 2018: United European Gastroenterology Journal
Amir Klein, Zhengyan Qi, Farzan F Bahin, Halim Awadie, Dhruv Nayyar, Michael Ma, Rogier P Voermans, Stephen J Williams, Eric Lee, Michael J Bourke
BACKGROUND:  Endoscopic resection of ampullary adenomas is a safe and effective alternative to surgical resection. A subgroup of patients have large laterally spreading lesions of the papilla Vateri (LSL-P), which are frequently managed surgically. Data on endoscopic resection of LSL-P are limited and long-term outcomes are unknown. The aim of this study was to compare the outcomes of endoscopic resection of LSL-P with those of standard ampullary adenomas. METHODS:  A retrospective analysis of a prospectively collected and maintained database was conducted...
May 16, 2018: Endoscopy
Chao Cheng, Shuang Guo, Dakinah Eastman G B Kollie, Wanli Zhang, Jun Xiao, Jun Liu, Xiaoming Lu, Yong Xiao
RATIONALE: The mesenteric desmoid tumor requires special attention and the most demanding treatment. PATIENT CONCERNS: Here we present a rare case of a large mesenteric desmoid tumor secondary to familial adenomatous polyposis (FAP) in a 34-year-old man accepted the ex vivo resection, and intestinal autotransplantation. DIAGNOSES: A 34-year-old man was referred to our department with a 6-year history of intermittent hematochezia without any other discomfort after undergoing partial colectomy in February 2013, and 5 endoscopic mucosal resections of colon polyps between May 2012 and July 2015 due to pathological diagnosis of FAP...
May 2018: Medicine (Baltimore)
Heechan Kang, Mo Hameed Thoufeeq
Background an study aims:  Polypectomy and endoscopic mucosal resection (EMR) are effective and safe ways of removing polyps from the colon at endoscopy. Guidelines exist for advising the time allocation for diagnostic endoscopy but not for polypectomy and EMR. The aim of this study was to identify if time allocated for polypectomy and EMR at planned therapeutic lists in our endoscopy unit is sufficient for procedures to be carried out. We also wanted to identify factors that might be associated with procedures taking longer than the allocated time and to identify factors that might predict duration of these procedures...
May 2018: Endoscopy International Open
Hideharu Ogiyama, Shusaku Tsutsui, Yoko Murayama, Shingo Maeda, Shin Satake, Ayaka Nasu, Daisuke Umeda, Yoshio Miura, Kouhei Tominaga, Masashi Horiki, Tamana Sanomura, Kazuho Imanaka, Hiroyasu Iishi
Background and study aims : Endoscopic submucosal dissection (ESD) has a high en bloc resection rate and is widely performed for large superficial colorectal tumors, but delayed bleeding remains one of the most common complications of colorectal ESD. The aim of the present study was to evaluate the clinical efficacy of prophylactic clip closure of mucosal defects for the prevention of delayed bleeding after colorectal ESD. Patients and methods : We enrolled consecutive patients with colorectal lesions between January 2012 and May 2017 in this retrospective study...
May 2018: Endoscopy International Open
Tan Attila, Erkan Parlak, Emrah Alper, Selçuk Dişibeyaz, Bahattin Çiçek, Bülent Ödemiş
BACKGROUND/AIMS: Endoscopic papillectomy (EP) has emerged as an alternative to surgery in the management of ampullary lesions. The aim of this study is to evaluate feasibility, efficacy, safety, outcome, and impact of EP in the management of benign ampullary lesions. MATERIALS AND METHODS: This is a multicenter, retrospective study of 44 patients who had EP of benign ampullary lesions. RESULTS: Over the 11-year period, 44 (55.7%) of 79 patients underwent EP for benign ampullary lesions...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Naohisa Yahagi, Motohiko Kato, Yasutoshi Ocihai, Tadateru Maehata, Motoki Sasaki, Yoshiyuki Kiguchi, Teppei Akimoto, Atsushi Nakayama, Ai Fujimoto, Osamu Goto, Toshio Uraoka
BACKGROUND AND AIM: Pancreaticoduodenectomy is an invasive procedure, and endoscopic resection (ER) is an alternative therapy. However, details regarding the outcomes of ER are unknown, especially for superficial duodenal epithelial neoplasia (SDET). The aim of this study was to elucidate the outcomes of ER for SDET and to compare endoscopic mucosal resection (EMR) with endoscopic submucosal dissection (ESD). METHODS: This was a retrospective observational study...
May 9, 2018: Gastrointestinal Endoscopy
Shai Friedland, George Triadafilopoulos
Effective endoscopic treatments for dysplasia and early (intramucosal) cancer, together with expanded and rigorous screening programs to detect Barrett's esophagus, could help reverse the increase in the incidence of esophageal cancer and reduce esophageal cancer-related mortality. In this review, we discuss the long-term outcomes for mucosal resection for dysplasia and early cancer and compares them to esophagectomy as the standard of care choice. Eendoscopic resection for Barrett's dysplasia and early cancer can be curative but only when the lesion can be classified as: Paris type I (polypoid); Paris IIa (slightly elevated); Paris IIb (flat); Paris IIc (slightly depressed); histological grades G1 and G2; high-grade dysplasia...
May 11, 2018: Annals of the New York Academy of Sciences
Alessandro Repici, Michael Wallace, Prateek Sharma, Pradeep Bhandari, Gianluca Lollo, Roberta Maselli, Cesare Hassan, Douglas K Rex
BACKGROUND: SIC-8000 (Eleview) is a new FDA-approved solution for submucosal injection developed to provide long-lasting cushion to facilitate endoscopic resection maneuvers. Our aim was to compare the efficacy and safety of SIC-8000 with those of saline solution, when performing endoscopic mucosal resection (EMR) of large colorectal lesions. METHODS: In a randomized double-blind trial, patients undergoing EMR for ≥20 mm colorectal non-pedunculated lesions were randomized in a 1:1 ratio between SIC-8000 and saline solution as control solution in 5 tertiary centers...
May 8, 2018: Gastrointestinal Endoscopy
Amol Agarwal, Sidyarth Garimall, Caitlin Colling, Nuzhat A Ahmad, Michael L Kochman, Gregory G Ginsberg, Vinay Chandrasekhara
PURPOSE: To investigate advanced neoplasia (AN) after endoscopic mucosal resection (EMR) of colonic laterally spreading lesions (LSLs). METHODS: A retrospective study of patients who underwent injection-assisted EMR of colonic LSLs ≥ 10 mm was performed. Primary outcome was overall rate of AN at initial surveillance colonoscopy. Secondary outcomes were the rates of residual AN (rAN) at the EMR site and metachronous AN (mAN), and analysis of risk factors for AN, including effect of surveillance guidance...
May 10, 2018: International Journal of Colorectal Disease
Takeshi Setoyama, Shin' Ichi Miyamoto, Mitsuhiro Nikaido, Takahiro Horimatsu, Shigemi Matsumoto, Yasumasa Ezoe, Shuko Morita, Ikuo Aoyama, Chiharu Kawanami, Toshihiro Kusaka, Tsutomu Chiba, Manabu Muto, Hiroshi Seno
Endoscopic treatments, including endoscopic mucosal resection or endoscopic submucosal dissection, are well accepted as standard treatments for early gastric cancers. However, there are few studies evaluating the safety and efficacy of this approach for early gastric cancers in patients aged over 80 years, and the post-treatment prognosis remains unclear. Here, we retrospectively analyzed the medical records and evaluated the safety and efficacy of endoscopic treatment for early gastric cancers in patients aged over 80 years (group A) compared with non-elderly patients aged 65-79 years (group B) and under 65 years (group C)...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Rajaratnam Rameshshanker, Zacharias Tsiamoulos, Andrew Latchford, Morgan Moorghen, Brian P Saunders
No abstract text is available yet for this article.
May 9, 2018: Endoscopy
Airong Tang, Cuiyun Ma, Pei Deng, Hanqing Zhang, Yang Xu, Min Min, Yan Liu
BACKGROUND: Esophageal stricture caused by endoscopic submucosal dissection for a mucosal defect that covers more than three quarters of the circumference of the esophagus has a high incidence. To date, no method for preventing such strictures has been widely recognized as effective in clinical practice. AIMS: We examined whether esophageal stricture caused by circumferential endoscopic submucosal dissection could be prevented by autologous flap transfer. METHODS: Six pigs (N = 6) underwent circumferential esophageal endoscopic submucosal dissection under general anesthesia...
May 8, 2018: Digestive Diseases and Sciences
Tak Lit Derek Fung, Pak Tat Chan, Ha Man Lee, Kam Hung Kwok
INTRODUCTION: It is not uncommon to encounter colorectal polyps which could not be removed easily by simple polypectomy. Endoscopic submucosal dissection (ESD) has been a well-established method for doing so. We compared the result between ESD and surgical removal of these difficult colorectal polyps. MATERIALS AND METHOD: During the period between January 2013 and December 2016, patients who have failed endoscopic removal of colorectal polyp requiring second treatment, either by ESD or surgical removal, were matched into two groups and reviewed...
May 4, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Seung-Joo Nam, Gi Bong Chae, Seungkoo Lee, Sung Chul Park, Chang Don Kang, Sung Joon Lee
The incidence of rectal neuroendocrine tumor (NET), which is often diagnosed during routine surveillance endoscopy, is increasing. The majority of these tumors are small and asymptomatic, possessing benign features with favorable prognoses. At present, small rectal NETs without high-risk factors are typically treated by local resection, including endoscopic mucosal resection, endoscopic submucosal dissection, or transanal endoscopic microsurgery, with or without additional imaging follow-up by abdominal computed tomography or magnetic resonance imaging...
May 2018: Oncology Letters
Ryan W Stidham, Peter D R Higgins
Patients with inflammatory bowel disease (IBD) are at significantly increased risk of colorectal cancer (CRC), principally resulting from the pro-neoplastic effects of chronic intestinal inflammation. Epidemiologic studies continue to highlight the increased risk of CRC in IBD. However, the incidence has declined over the past 30 years, attributed to both successful CRC-surveillance programs and improved control of mucosal inflammation. Risk factors that further increase the risk of IBD-related CRC include disease duration, extent and severity, the presence of inflammatory pseudopolyps, coexistent primary sclerosing cholangitis, and a family history of CRC...
May 2018: Clinics in Colon and Rectal Surgery
Pietro Gambitta, Francesca Iannuzzi, Alessandro Ballerini, Alessandra D'Alessandro, Maurizio Vertemati, Emilia Bareggi, Stefano Pallotta, Paola Fontana, Paolo Aseni
Background: Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are increasingly used for the treatment of superficial gastrointestinal neoplasia. However, the limits and the indications for each technique are still debated. Our retrospective study aimed to compare these techniques in patients with gastric flat lesions larger than 20 mm without the non-lifting sign. Methods: Between January 2013 and July 2016, a total of 36 patients with early gastric flat lesions larger than 20 mm and without the non-lifting sign were resected by ESD and were followed up by endoscopy...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Maximilien Barret, Frédéric Prat
Endoscopy allows for the screening, early diagnosis, treatment and follow up of superficial esophageal cancer. Endoscopic submucosal dissection has become the gold standard for the resection of superficial squamous cell neoplasia. Combinations of endoscopic mucosal resection and radiofrequency ablation are the mainstay of the management of Barrett's associated neoplasia. However, protruded, non-lifting or large lesions may be better managed by endoscopic submucosal dissection. Novel ablation tools, such as argon plasma coagulation with submucosal lifting and cryoablation balloons, are being developed for the treatment of residual Barrett's esophagus, since iatrogenic strictures still hamper the development of extensive circumferential resections in the esophagus...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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