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AKI on CKD

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https://www.readbyqxmd.com/read/29344507/definition-management-and-outcomes-of-acute-kidney-injury-an-international-survey-of-nephrologists
#1
Umar Farooq, Aaron Tober, Vernon Chinchilli, W Brian Reeves, Nasrollah Ghahramani
Background: Acute kidney injury (AKI) is a complex disease burdened by uncertainties of definition, management strategies, and prognosis. This study explores the relationship between demographic characteristics of nephrologists and their perceptions about the definition, management, and follow-up of AKI. Methods: We developed a Web-based survey, the International Survey on Acute Kidney Injury (ISAKI), consisting of 29 items in 4 categories: (1) demographic and practice characteristics, (2) definition of AKI, (3) management of renal replacement therapy (RRT) in AKI, and (4) sequelae of AKI...
December 2017: Kidney Diseases
https://www.readbyqxmd.com/read/29341864/comparison-of-acute-kidney-injury-of-different-aetiology-reveals-in-common-mechanisms-of-tissue-damage
#2
Michael Hultström, Mediha Becirovic-Agic, Sofia Jönsson
Acute kidney injury (AKI) is a syndrome of reduced glomerular filtration rate (GFR) and urine production caused by a number of different diseases. It is associated with renal tissue damage. This tissue damage can cause tubular atrophy and interstitial fibrosis that leads to nephron loss and progression of chronic kidney disease (CKD). This review describes the in-common mechanisms behind tissue damage in AKI caused by different underlying diseases. Comparing six high-quality microarray studies of renal gene expression after AKI in disease models (gram-negative sepsis, gram-positive sepsis, ischemia-reperfusion, malignant hypertension, rhabdomyolysis and cisplatin toxicity) identified 5254 differentially expressed genes in at least one of the AKI models...
December 20, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/29324683/pentoxifylline-and-methylprednisolone-additively-alleviate-kidney-failure-and-prolong-survival-of-rats-after-renal-warm-ischemia-reperfusion
#3
Grzegorz Wystrychowski, Wojciech Wystrychowski, Władysław Grzeszczak, Andrzej Więcek, Robert Król, Antoni Wystrychowski
Renal ischemia-reperfusion injury (IRI) induces local inflammation leading to kidney damage. Since pentoxifylline (PTX) and steroids have distinct immunomodulatory properties, we aimed to evaluate for the first time their combined use in IRI-induced acute kidney injury (AKI) and chronic kidney disease (CKD) in rats. In two experiments, PTX (100 mg/kg body weight subcutaneously) was administered 90 min prior to renal IRI or/and methylprednisolone (MP; 100 mg/kg body weight intramuscularly) was infused 60 min after reperfusion of a solitary kidney (AKI model: 45 min ischemia, 48 male Sprague-Dawley rats) or one kidney with excision of contralateral kidney 2 weeks later (CKD model: 90 min ischemia, 38 rats)...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29302904/acute-kidney-injury-in-pregnancy-with-special-reference-to-pregnancy-specific-disorders-a-hospital-based-study-2014-2016
#4
Jai Prakash, Vivek C Ganiger, Suraj Prakash, Mohammad Iqbal, Deba Prasad Kar, Usha Singh, Ashish Verma
INTRODUCTION: There are numerous reports in the literature describing acute kidney injury in pregnancy (P-AKI) due to various obstetric complications. However, there is a dearth of studies on AKI related to pregnancy-specific disorders from India. We aimed to analyze clinical features and outcome of P-AKI related to pregnancy-specific disorders compared to total pregnancy, in India. METHOD: All pregnant women attending the department of Obstetrics and Gynecology from November 2014 to July 2016 were screened for AKI based on: (1) sudden elevation of serum creatinine ≥ 1 mg/dl; (2) oligoanuria for > 12 h; and (3) need for dialysis...
January 4, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29286569/patterns-of-kidney-injury-in-pediatric-non-kidney-solid-organ-transplant-recipients
#5
C Williams, K Borges, T Banh, J Vasilevska-Ristovska, R Chanchlani, V L Ng, A I Dipchand, M Solomon, D Hebert, S J Kim, B C Astor, R S Parekh
The incidence of acute kidney injury (AKI) and its impact on chronic kidney disease (CKD) following pediatric non-kidney solid organ transplantation is unknown. We aimed to determine the incidence of AKI and CKD and examine their relationship among children who received a heart, lung, liver or multi-organ transplant at the Hospital for Sick Children between 2002 and 2011. AKI was assessed in the first year post-transplant. Among 303 children, perioperative AKI (within the first week) occurred in 67% of children, and AKI after the first week occurred in 36%, with the highest incidence among lung and multi-organ recipients...
December 29, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29285953/incidence-characteristics-and-prognosis-of-acute-kidney-injury-in-cameroon-a-prospective-study-at-the-douala-general-hospital
#6
Marie Patrice E Halle, Ndjifoum Moselle Chipekam, Gérard Beyiha, Hermine Fouda, Aminata Coulibaly, Romuald Hentchoya, Folefack Francois Kaze, Namme Henry Luma, Gloria Ashuntantang
OBJECTIVE: There are limited data on AKI in sub-Saharan Africa. We aim to determine the incidence, characteristics and prognosis of AKI in Cameroon. PATIENTS AND METHODS: A prospective study including all consenting acute admissions in the internal medicine and the ICU of a tertiary referral hospital in Cameroon from January 2015 to June 2016. Serum creatinine assay was done on admission, days 2 and 7 to diagnose AKI. For patients with AKI, serum creatinine was done on discharge, days 30, 60 and 90...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29283932/glomerular-filtration-rate-is-unchanged-by-ultramarathon
#7
Wojciech Wołyniec, Wojciech Ratkowski, Katarzyna Kasprowicz, Zbigniew Jastrzębski, Sylwia Małgorzewicz, Konrad Witek, Tomasz Grzywacz, Piotr Żmijewski, Marcin Renke
THE MAIN PROBLEM: Acute kidney injury (AKI) is reported as a common complication of marathon and ultramarathon running. In previous studies AKI was diagnosed on the basis of the creatinine level in serum and estimated glomerular filtration rate (eGFR). In the present study we calculated eGFR and also measured creatinine clearance after every 25 km of a 100 km run. METHODS: 20 healthy, amateur runners (males, mean age 40.75 ± 7.15 years, mean weight 76.87 ± 8.39 kg) took part in a 100 km run on a track...
December 27, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29283473/international-statistical-classification-of-diseases-and-related-health-problems-coding-underestimates-the-incidence-and-prevalence-of-acute-kidney-injury-and-chronic-kidney-disease-in-general-medical-patients
#8
Soe Ko, Sudharsan Venkatesan, Kushma Nand, Vicki Levidiotis, Craig Nelson, Edward Janus
BACKGROUND: The International classification of diseases (ICD) code is frequently used to identify renal impairment in epidemiologic research. However, Australian studies examining accuracy of this administrative data in coding kidney injury are lacking. AIMS: To compare the ICD 10 coding with the Kidney Disease: Improving Global Outcomes (KDIGO) criteria in diagnosing Acute Kidney Injury (AKI) and/or Chronic Kidney Disease (CKD). METHODS: A retrospective study of 325 patients admitted to General Medicine during January 2012 was performed...
December 28, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29282093/timing-of-renal-replacement-therapy-and-long-term-risk-of-chronic-kidney-disease-and-death-in-intensive-care-patients-with-acute-kidney-injury
#9
Søren Christiansen, Steffen Christensen, Lars Pedersen, Henrik Gammelager, J Bradley Layton, M Alan Brookhart, Christian Fynbo Christiansen
BACKGROUND: The optimal time to initiate renal replacement therapy (RRT) in intensive care unit (ICU) patients with acute kidney injury (AKI) is unclear. We examined the impact of early RRT on long-term mortality, risk of chronic kidney disease (CKD), and end-stage renal disease (ESRD). METHODS: This cohort study included all adult patients treated with continuous RRT in the ICU at Aarhus University Hospital, Skejby, Denmark (2005-2015). Data were obtained from a clinical information system and population-based registries...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29236211/association-of-whole-blood-tacrolimus-concentrations-with-kidney-injury-in-heart-transplantation-patients
#10
Maaike A Sikma, Claudine C Hunault, Johannes H Kirkels, Marianne C Verhaar, Jozef Kesecioglu, Dylan W de Lange
BACKGROUND AND OBJECTIVES: Acute kidney injury (AKI) is frequently observed after heart transplantation and is associated with morbidity and mortality. However, many confounding factors also contribute to the development of AKI in heart transplants. We hypothesized that supratherapeutic whole-blood tacrolimus trough concentrations are associated with AKI. METHODS: In a retrospective observational cohort from April 2005 to December 2012, all adult heart transplantation patients were included...
December 13, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29222395/extracellular-adenosine-stimulates-vacuolar-atpase-dependent-proton-secretion-in-medullary-intercalated-cells
#11
Maria A Battistone, Anil V Nair, Claire R Barton, Rachel N Liberman, Maria A Peralta, Diane E Capen, Dennis Brown, Sylvie Breton
Acidosis is an important complication of AKI and CKD. Renal intercalated cells (ICs) express the proton pumping vacuolar H+-ATPase (V-ATPase) and are extensively involved in acid-base homeostasis. H+ secretion in type A intercalated cells (A-ICs) is regulated by apical vesicle recycling and stimulated by cAMP. In other cell types, cAMP is increased by extracellular agonists, including adenosine, through purinergic receptors. Adenosine is a Food and Drug Administration-approved drug, but very little is known about the effect of adenosine on IC function...
December 8, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29212494/epidemiology-and-outcomes-of-children-with-renal-failure-in-the-pediatric-ward-of-a-tertiary-hospital-in-cameroon
#12
Marie Patrice Halle, Carine Tsou Lapsap, Esther Barla, Hermine Fouda, Hilaire Djantio, Beatrice Kaptue Moudze, Christophe Adjahoung Akazong, Eugene Belley Priso
BACKGROUND: Pediatric nephrology is challenging in developing countries and data on the burden of kidney disease in children is difficult to estimate due to absence of renal registries. We aimed to describe the epidemiology and outcomes of children with renal failure in Cameroon. METHODS: We retrospectively reviewed 103 medical records of children from 0 to 17 years with renal failure admitted in the Pediatric ward of the Douala General Hospital from 2004 to 2013...
December 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29212486/emerging-concepts-and-spectrum-of-renal-injury-following-intravesical-bcg-for-non-muscle-invasive-bladder-cancer
#13
Azharuddin Mohammed, Zubair Arastu
BACKGROUND: Intravesical Bacilli Calmette-Guerin (IVBCG) therapy for non-muscle invasive bladder cancer (NMIBC) has long been in use successfully. Albeit rarely, we still face with its safety concerns more than 25 years on since its approval by US Food and Drug Agency in 1990. Local and systemic infection following intravesical BCG is widely reported as compared to immune mediated local or systemic hypersensitivity reactions involving kidneys; acute kidney injury (AKI) and other renal manifestations are well reported but not of chronic kidney disease (CKD)...
December 6, 2017: BMC Urology
https://www.readbyqxmd.com/read/29202871/mesenchymal-stem-cell-derived-extracellular-vesicles-for-kidney-repair-current-status-and-looming-challenges
#14
REVIEW
Arash Aghajani Nargesi, Lilach O Lerman, Alfonso Eirin
Novel therapies are urgently needed to address the rising incidence and prevalence of acute kidney injury (AKI) and chronic kidney disease (CKD). Mesenchymal stem/stromal cells (MSCs) have shown promising results in experimental AKI and CKD, and have been used in the clinic for more than a decade with an excellent safety profile. The regenerative effects of MSCs do not rely on their differentiation and ability to replace damaged tissues, but are primarily mediated by the paracrine release of factors, including extracellular vesicles (EVs), composed of microvesicles and exosomes...
December 4, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29196746/diabetes-aggravates-post-ischaemic-renal-fibrosis-through-persistent-activation-of-tgf-%C3%AE-1-and-shh-signalling
#15
Dong-Jin Kim, Jun Mo Kang, Seon Hwa Park, Hyuk-Kwon Kwon, Seok-Jong Song, Haena Moon, Su-Mi Kim, Jung-Woo Seo, Yu Ho Lee, Yang Gyun Kim, Ju-Young Moon, So-Young Lee, Youngsook Son, Sang-Ho Lee
Diabetes is a risk factor for acute kidney injury (AKI) and chronic kidney disease (CKD). Diabetic patients are easy to progress to CKD after AKI. Currently, activation of fibrotic signalling including transforming growth factor-β1 (TGF-β1) is recognized as a key mechanism in CKD. Here, we investigated the influence of diabetes on CKD progression after AKI by using a unilateral renal ischaemia-reperfusion injury (IRI) model in diabetic mice. IRI induced extensive tubular injury, fibrosis and lymphocyte recruitment at 3 weeks after IRI, irrespective of diabetes...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29191959/clinical-translation-of-mesenchymal-stromal-cell-therapies-in-nephrology
#16
Norberto Perico, Federica Casiraghi, Giuseppe Remuzzi
Mesenchymal stromal cells have emerged as potential candidates for cell-based therapies to modulate the immune response in organ transplantation and repair tissues after acute or chronic injury. Preclinical studies have shown convincingly in rodent models that mesenchymal stromal cells can prolong solid organ graft survival and that they can induce immune tolerance, accelerate recovery from AKI, and promote functional improvement in chronic nephropathies. Multiple complex properties of the cells, including immunomodulatory, anti-inflammatory, and proregenerative effects, seem to contribute...
November 30, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29190600/hyaluronic-acid-as-a-new-biomarker-to-differentiate-acute-kidney-injury-from-chronic-kidney-disease
#17
Davut Akin, Sehmus Ozmen, Mehmet Emin Yilmaz
INTRODUCTION: It may be difficult to differentiate acute kidney injury from chronic kidney disease in patients with no past medical reports of kidney function. This study aimed to investigate the role of serum hyaluronic acid (HA), which is known as a marker of fibrosis, in differential diagnosis of kidney failure. MATERIALS AND METHODS: A total of 90 patients (52 women and 38 mne) admitted to our renal unit with uremia for the first time were included. Serum HA level was measured...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29184415/reversible-preoperative-renal-dysfunction-does-not-add-to-the-risk-of-postoperative-acute-kidney-injury-after-cardiac-valve-surgery
#18
Jia-Rui Xu, Ya-Min Zhuang, Lan Liu, Bo Shen, Yi-Mei Wang, Zhe Luo, Jie Teng, Chun-Sheng Wang, Xiao-Qiang Ding
Objective: To evaluate the impact of the renal dysfunction (RD) type and change of postoperative cardiac function on the risk of developing acute kidney injury (AKI) in patients who underwent cardiac valve surgery. Method: Reversible renal dysfunction (RRD) was defined as preoperative RD in patients who had not been initially diagnosed with chronic kidney disease (CKD). Cardiac function improvement (CFI) was defined as postoperative left ventricular ejection function - preoperative left ventricular ejection function (ΔEF) >0%, and cardiac function not improved (CFNI) as ΔEF ≤0%...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29179178/serum-cystatin-c-predicts-aki-and-the-prognosis-of-patients-in-coronary-care-unit-a-prospective-observational-study
#19
Yugang Hu, Huilan Liu, Liguo Du, Jing Wan, Xiaoning Li
BACKGROUND/AIMS: Acute Kidney Injury (AKI) is a serious clinical state associated with high morbidity and mortality, particularly in critical ill patients. We investigated the hypothesis that serum Cystatin C (sCysC) is a good predictor for AKI and may affect the short-term prognosis of coronary care unit (CCU) patients. METHODS: In this prospective, observational study, we screened 412 adults admitted to the CCU from January 1, 2014 to June 1, 2015 at Zhongnan Hospital of Wuhan University...
November 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29175613/chronic-kidney-disease-after-acute-kidney-injury-associated-with-intravenous-colistin-use-in-survivors-of-severe-infections-a-comparative-cohort-study
#20
Alejandro Meraz-Muñoz, Ismael Gomez-Ruiz, Ricardo Correa-Rotter, Juan C Ramirez-Sandoval
PURPOSE: The use of colistin for multi-drug resistant (MDR) infections has led to an increase of colistin-associated acute kidney injury (AKI). Nevertheless, information on long-term renal prognosis is scarce. We aimed to determine the predictors of chronic kidney disease (CKD) in survivors of MDR-infections with colistin-associated AKI. METHODS: A retrospective cohort of patients with colistin-associated AKI was compared with controls (survivors of severe infections who developed AKI matched by age, sex, diabetes, vancomycin exposure, and baseline kidney function)...
November 15, 2017: Journal of Critical Care
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