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https://www.readbyqxmd.com/read/28633741/high-frequency-ultrasound-features-in-a-case-of-gouty-panniculitis
#1
P Maldonado Cid, C Rubio Flores, I Prats Caelles, V M Leis Dosil, F Alfageme Roldán, P Richi Alberti, C Santonja Garriga, R M Díaz Díaz
Gouty panniculitis is caused by the deposition of urate crystals in the subcutaneous tissue, accompanied by a lobular panniculitis. It presents as subcutaneous nodules, most commonly located on the lower extremities. Being an unusual clinical presentation of gout, the sonographic findings of gouty panniculitis have been scarcely described in the literature. Our report describes the ultrasound features we found in a case of gouty panniculitis and the usefulness of this technique for diagnosis and monitoring of this disease...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28632507/tibialis-posterior-tenosynovitis-a-unique-musculoskeletal-manifestation-of-gout
#2
Peter Shupper, Todd P Stitik
Extra-articular manifestations of gout can present in several ways, including tenosynovitis. We present a rare case of acute tibialis posterior gouty tenosynovitis. An 82-year-old man with a history of well-controlled gout presented with acute onset of left ankle pain, occurring without inciting event. The medial ankle was slightly erythematous with moderate dorsal-medial swelling and mild dorsal-lateral swelling, with severe tenderness to palpation over the medial retro-malleolar region. Range of motion and manual muscle testing were pain limited throughout...
June 20, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28631693/-independent-risk-factors-for-severe-cardiovascular-events-in-male-patients-with-gout-results-of-a-7-year-prospective-study
#3
M S Eliseev, I S Denisov, E I Markelova, S I Glukhova, E L Nasonov
AIM: To determine risk factors for severe cardiovascular (CV) events (CVEs) in male patients with crystal-verified gout. SUBJECTS AND METHODS: 251 male patients with crystal-verified gout were prospectively followed up in 2003 to 2013. The mean follow-up period was 6.9±2.0 years. New severe CVE cases and deaths were recorded. Logistic regression was used to analyze the impact of traditional and other risk factors and allopurinol use on the risk for severe CVEs...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28631197/prioritizing-future-research-on-allopurinol-and-febuxostat-for-the-management-of-gout-value-of-information-analysis
#4
Eric Jutkowitz, Fernando Alarid-Escudero, Hyon K Choi, Karen M Kuntz, Hawre Jalal
OBJECTIVES: The aim of this study was to quantify the value of conducting additional research and reducing uncertainty regarding the cost effectiveness of allopurinol and febuxostat for the management of gout. METHODS: We used a previously developed Markov model that evaluated the cost effectiveness of nine urate-lowering strategies: no treatment, allopurinol-only fixed dose (300 mg), allopurinol-only dose escalation (up to 800 mg), febuxostat-only fixed dose (80 mg), febuxostat-only dose escalation (up to 120 mg), allopurinol-febuxostat sequential therapy fixed dose, allopurinol-febuxostat sequential therapy dose escalation, febuxostat-allopurinol sequential therapy fixed dose, and febuxostat-allopurinol sequential therapy dose escalation...
June 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28630380/the-immunological-basis-in-the-pathogenesis-of-gout
#5
Junwei Chen, Meng Wu, Jinhua Yang, Jing Wang, Yue Qiao, Xiaofeng Li
Gout is an inflammatory arthritis characterized by red, tender, hot and tumid joints. The development cause and process of gout is very sophisticated; recent studies, notwithstanding, have offered novel perspectives on the mechanism from an immunological viewpoint. The pathological process of gout involves both innate and adaptive immune responses. Other studies have demonstrated that gout development is associated with the presence of monosodium urate (MSU) crystals which serve as a "danger signal" affecting certain immune cells, cytokine production, and effector molecule expression, triggering both types of immune responses...
June 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28623421/comparison-of-dual-energy-ct-ultrasound-and-surface-measurement-for-assessing-tophus-dissolution-during-rapid-urate-debulking
#6
Dodji V Modjinou, Svetlana Krasnokutsky, Soterios Gyftopoulos, Virginia C Pike, Elaine Karis, Robert T Keenan, Kristen Lee, Daria B Crittenden, Jonathan Samuels, Michael H Pillinger
Tophaceous gout is painful and impairs quality of life. The optimal modality for assessing tophus resolution in response to urate-lowering treatment remains poorly defined. Using pegloticase as a model system for resolving tophi, we compared multiple imaging and physical diagnostic strategies for assessing tophus resolution. A 32-year-old subject with chronic refractory tophaceous gout was enrolled and received 6 months of pegloticase treatment. Measurements of tophi using vernier calipers (monthly), photographs and musculoskeletal ultrasound (MSK-US; every 3 months), and dual-energy CT (DECT) were compared...
June 16, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28618105/factors-influencing-medication-adherence-in-patients-with-gout-a-descriptive-correlational-study
#7
Xin Hui Jasmine Chua, Siriwan Lim, Fui Ping Lim, Yee Nah Anita Lim, Hong-Gu He, Gim Gee Teng
AIMS AND OBJECTIVES: To examine the factors influencing adherence to urate-lowering therapy in patients with gout in Singapore. BACKGROUND: Gout is the most common type of chronic inflammatory arthritis. Urate-lowering therapy (ULT) is used to treat gout by reducing serum uric acid levels. However, adherence to ULT among patients remains poor. To date, there have been no available studies based on a conceptual framework that examined factors influencing medication adherence in patients with gout...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28617199/an-optimal-ultrasonographic-diagnostic-test-for-early-gout-a-prospective-controlled-study
#8
Eleonora Norkuviene, Mykolas Petraitis, Indre Apanaviciene, Dalia Virviciute, Asta Baranauskaite
Objective To identify the optimal sites for classification of early gout by ultrasonography. Methods Sixty patients with monosodium urate crystal-proven gout (25 with early gout [≤2-year symptom duration], 35 with late gout [>2-year symptom duration], and 36 normouricemic healthy controls) from one centre were prospectively evaluated. Standardized blinded ultrasound examination of 36 joints and the triceps and patellar tendons was performed to identify tophi and the double contour (DC) sign. Results Ultrasonographic sensitivity was lower in early than late gout...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28609463/uric-acid-an-important-antioxidant-contributing-to-survival-in-termites
#9
Eisuke Tasaki, Hiroki Sakurai, Masaru Nitao, Kenji Matsuura, Yoshihito Iuchi
Reactive oxygen species (ROS) are generated spontaneously in all organisms and cause oxidative damage to biomolecules when present in excess. Accumulated oxidative damage accelerates aging; enhanced antioxidant capacity may be a positive factor for longevity. Recently, numerous studies of aging and longevity have been performed using short-lived animals, however, longevity mechanisms remain unknown. Here we show that a termite Reticulitermes speratus that is thought to be long-lived eusocial insect than other solitary insects uses large quantities of uric acid as an antioxidant against ROS...
2017: PloS One
https://www.readbyqxmd.com/read/28605749/radiculopathy-in-a-patient-with-chronic-tophaceus-gout-vertebral-imaging
#10
Joana Borges, Cláudia Miguel, Susana Fernandes, Rui Leitão, Augusto Faustino
INTRODUCTION: Spinal involvement is infrequent in chronic gout. However, some cases of back pain with radiculopathy secondary to this etiology have been reported. CASE REPORT: 56-year old male patient, with history of arterial hypertension, hypertriglyceridemia, obesity, glucose intolerance and alcohol abuse, diagnosed with gout in his fifth decade of life. The patient was started on urate lowering therapy, with poor compliance, and evolved with sustained hyperuricemia, recurrent episodes of arthritis, and growth of gouty tophi on the elbows, wrists, hands and knees...
June 2, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28605531/the-british-society-for-rheumatology-guideline-for-the-management-of-gout
#11
Michelle Hui, Alison Carr, Stewart Cameron, Graham Davenport, Michael Doherty, Harry Forrester, Wendy Jenkins, Kelsey M Jordan, Christian D Mallen, Thomas M McDonald, George Nuki, Anthony Pywell, Weiya Zhang, Edward Roddy
No abstract text is available yet for this article.
June 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/28597604/lesinurad-a-selective-uric-acid-reabsorption-inhibitor-in-combination-with-febuxostat-in-patients-with-tophaceous-gout-a-phase-iii-clinical-trial
#12
Nicola Dalbeth, Graeme Jones, Robert Terkeltaub, Dinesh Khanna, Jeff Kopicko, Nihar Bhakta, Scott Adler, Maple Fung, Chris Storgard, Scott Baumgartner, Fernando Perez-Ruiz
OBJECTIVE: Investigate efficacy and safety of lesinurad in combination with febuxostat in patients with tophaceous gout in a 12-month, phase III trial. METHODS: Patients with serum urate (sUA) ≥8.0 mg/dl (≥6.0 mg/dl on urate-lowering therapy) and ≥1 measurable target tophus were given febuxostat 80mg daily for 3 weeks before randomization to lesinurad (200 or 400mg daily) or placebo added to febuxostat. Primary endpoint was proportion of patients achieving sUA <5...
June 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28597317/erratum-to-plasma-exchange-response-in-34-patients-with-severe-optic-neuritis
#13
Romain Deschamps, Antoine Gueguen, Nathalie Parquet, Samir Saheb, Francoise Driss, Malcie Mesnil, Catherine Vignal, Jennifer Aboab, Raphael Depaz, Olivier Gout
No abstract text is available yet for this article.
June 8, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28597134/digital-tomosynthesis-as-a-new-diagnostic-tool-for-assessing-of-chronic-gout-arthritic-feet-and-ankles-comparison-of-plain-radiography-and-computed-tomography
#14
Chang-Nam Son, Yoonah Song, Sang-Hyon Kim, Seunghun Lee, Jae-Bum Jun
This aimed to compare the three radiographic methods of digital tomosynthesis (DT), plain radiography, and computed tomography (CT) for evaluating changes in feet of patients with chronic gouty arthritis. Two independent radiologists read the plain radiography, DT, and CT images of 30 male patients with gout. The degrees of erosion and joint space narrowing were scored using the Sharp-van der Heijde scoring method in 18 foot joints, which consisted of four proximal interphalangeal and one interphalangeal joint of the first toe, five metatarsophalangeal, five tarsometatarsal, and three naviculo-cuneiform joints of the foot...
June 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28594873/oral-uricase-eliminates-blood-uric-acid-in-the-hyperuricemic-pig-model
#15
Paulina Szczurek, Nadia Mosiichuk, Jarosław Woliński, Tetiana Yatsenko, Danica Grujic, Liudmyla Lozinska, Marek Pieszka, Ewa Święch, Stefan Grzegorz Pierzynowski, Kateryna Goncharova
An elevated level of serum uric acid-hyperuricemia, is strongly associated with the development of gout and chronic kidney disease (CKD) which is often accompanied by a significantly reduced glomerular filtration rate (GFR). In the present study, we investigated the extra-renal elimination of uric acid via the intestine in a healthy pig model and the effect of oral uricase therapy on plasma uric acid concentrations in pigs with induced hyperuricemia and CKD. The experiment was conducted on eleven, ten-week-old pigs (n = 11)...
2017: PloS One
https://www.readbyqxmd.com/read/28592718/long-term-subclinical-hyperglycemia-and-hypoglycemia-as-independent-risk-factors-for-mild-cognitive-impairment-in-elderly-people
#16
Feng Wang, Minghui Zhao, Zhaoli Han, Dai Li, Shishuang Zhang, Yongqiang Zhang, Xiaodong Kong, Qiang Zhang, Ping Lei
Dementia is one of the most common geriatric diseases, and mild cognitive impairment (MCI) is considered to be incipient dementia. MCI patients have elevated risk of progressing to dementia. Multiple metabolic abnormalities have an unconfirmed effect on MCI risk, and taking adequate measures against metabolic abnormalities might prevent the developing of MCI. Thus, the present study explored the association of MCI risk with common metabolic abnormalities, such as hyperglycemia, hypoglycemia, hyperlipidemia and hypouricemia, and to provide the basis for MCI prevention...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28592419/serum-uric-acid-levels-and-multiple-health-outcomes-umbrella-review-of-evidence-from-observational-studies-randomised-controlled-trials-and-mendelian-randomisation-studies
#17
REVIEW
Xue Li, Xiangrui Meng, Maria Timofeeva, Ioanna Tzoulaki, Konstantinos K Tsilidis, P A Ioannidis, Harry Campbell, Evropi Theodoratou
Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels.Design Umbrella review.Data sources Medline, Embase, Cochrane Database of Systematic Reviews, and screening of citations and references.Eligibility criteria Systematic reviews and meta-analyses of observational studies that examined associations between SUA level and health outcomes, meta-analyses of randomised controlled trials that investigated health outcomes related to SUA lowering treatment, and Mendelian randomisation studies that explored the causal associations of SUA level with health outcomes...
June 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28587655/gout-and-subsequent-erectile-dysfunction-a-population-based-cohort-study-from-england
#18
Alyshah Abdul Sultan, Christian Mallen, Richard Hayward, Sara Muller, Rebecca Whittle, Matthew Hotston, Edward Roddy
BACKGROUND: An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level absolute and relative rate of ED reporting among men with gout over a decade in England. METHODS: We utilised the UK-based Clinical Practice Research Datalink to identify 9653 men with incident gout age- and practice-matched to 38,218 controls. Absolute and relative rates of incident ED were calculated using Cox regression models...
June 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28586902/management-of-gout
#19
Paul G Shekelle, Sydne J Newberry
No abstract text is available yet for this article.
June 6, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28586901/management-of-gout
#20
Jasvinder A Singh, Kenneth G Saag
No abstract text is available yet for this article.
June 6, 2017: Annals of Internal Medicine
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