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https://www.readbyqxmd.com/read/29232325/utility-of-electronic-medical-records-in-community-rheumatology-practice-for-assessing-quality-of-care-indicators-for-gout-a-feasibility-study
#1
Augusto Estrada, Nicole W Tsao, Alyssa Howren, John M Esdaile, Kamran Shojania, Mary A De Vera
OBJECTIVES: With comprehensive capture of information on patient encounters, electronic medical records (EMRs) may have utility for assessing adherence to quality indicators (QIs) in gout. Our objectives were to translate 10 previously established gout QIs into relevant EMR data and evaluate and describe the feasibility of using EMRs to assess gout QIs. METHODS: Using EMRs from 3 community rheumatology practices in Vancouver, British Columbia, Canada, we identified gout patients seen between January 1, 2012, and December 31, 2013...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29232321/elevated-interleukin-1%C3%AE-and-interleukin-6-levels-in-the-serum-of-children-with-hyperuricemia
#2
Yazhen Di, Jiapei Wang, Yuanling Chen, Nan Sun, Ling Wu, Xiahua Dai, Mengjiao Shen, Qianqian Ying, Shiwei Fu
PURPOSES: The aim of this study was to investigate the serum levels and clinical significance of interleukin 1β (IL-1β) and IL-6 in children with hyperuricemia (HUA). METHODS: We included 71 children with HUA and 71 children with no HUA as control subjects. Children with HUA were divided into groups I and II according to whether they had a history of acute gout-like attacks (including sudden monoarthritis of rapid onset with intense pain and swelling). Group I was examined twice (A, in the acute phase; B, in the remission phase)...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29225919/multiple-common-and-rare-variants-of-abcg2-cause-gout
#3
Toshihide Higashino, Tappei Takada, Hirofumi Nakaoka, Yu Toyoda, Blanka Stiburkova, Hiroshi Miyata, Yuki Ikebuchi, Hiroshi Nakashima, Seiko Shimizu, Makoto Kawaguchi, Masayuki Sakiyama, Akiyoshi Nakayama, Airi Akashi, Yuki Tanahashi, Yusuke Kawamura, Takahiro Nakamura, Kenji Wakai, Rieko Okada, Ken Yamamoto, Kazuyoshi Hosomichi, Tatsuo Hosoya, Kimiyoshi Ichida, Hiroshi Ooyama, Hiroshi Suzuki, Ituro Inoue, Tony R Merriman, Nariyoshi Shinomiya, Hirotaka Matsuo
Objective: Previous studies have suggested an association between gout susceptibility and common dysfunctional variants in ATP-binding cassette transporter subfamily G member 2/breast cancer resistance protein (ABCG2/BCRP), including rs72552713 (Q126X) and rs2231142 (Q141K). However, the association of rare ABCG2 variants with gout is unknown. Therefore, we investigated the effects of rare ABCG2 variants on gout susceptibility in this study. Methods: We sequenced the exons of ABCG2 in 480 patients with gout and 480 healthy controls (Japanese males)...
2017: RMD Open
https://www.readbyqxmd.com/read/29219814/cellulitis-current-insights-into-pathophysiology-and-clinical-management
#4
D R Cranendonk, A P M Lavrijsen, J M Prins, W J Wiersinga
Cellulitis is a bacterial skin and soft tissue infection which occurs when the physical skin barrier, the immune system and/or the circulatory system are impaired. Diabetes, obesity and old age are associated with defects in all of these areas and as a result are major predisposing factors for cellulitis. In this review, we summarise current insights into the pathophysiology of cellulitis and place the Dutch guidelines on the clinical management of cellulitis of the lower extremities in perspective. Recent evidence on diagnostic strategies is discussed, the importance of which is underscored by findings that venous insufficiency, eczema, deep vein thrombosis and gout are frequently mistaken for cellulitis...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29217890/nontubercular-mycobacterial-infection-in-a-renal-allograft-recipient
#5
U Anandh, K Jayanna
A 71-year-old male, a renal allograft recipient, presented to us with a history of fever and right palm swelling. He had a history of fever 7 years back when he was treated with antitubercular treatment (ATT). Three years back, he was diagnosed to have gout and he was started on allopurinol. He developed severe bone marrow toxicity and allopurinol was changed to febuxostat. On admission, routine investigations did not reveal any focus of infection. The fluid aspirate from the palm revealed acid-fast bacilli (AFB)...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29215084/variants-of-alpk1-with-abcg2-slc2a9-and-slc22a12-increased-the-positive-predictive-value-for-gout
#6
Hung-Pin Tu, Albert Min-Shan Ko, Su-Shin Lee, Chi-Pin Lee, Tzer-Min Kuo, Chung-Ming Huang, Ying-Chin Ko
We investigated the interactions of ALPK1 variants and the loci of ABCG2, SLC2A9, and SLC22A12 on gout risk. We conducted two case-control studies. Participants were recruited from hospitals (n = 410; 104 gout cases and 306 controls) and communities (n = 678; 373 gout cases and 305 controls) in Taiwan. The genotypes of ALPK1 (rs11726117 M861T, rs231247 R1084R, and rs231253 3' UTR), ABCG2 (rs2231142 Q141K and rs2231137 V12M), SLC2A9 (rs3733591 R265H and rs1014290), and SLC22A12 (rs3825016 H86H, rs11231825 H142H, and rs475688) were genotyped...
November 8, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29214511/managing-gout-flares-in-the-elderly-practical-considerations
#7
Abhishek Abhishek
Gout is common in the elderly, affecting an estimated 4.7 million people aged > 60 years in the USA alone. The incidence and prevalence of gout increases, and male predisposition to gout reduces, with increasing age. The elderly have more comorbidities, and gout manifests differently, with more frequent involvement of knees, ankles, and wrists at disease onset, systemic upset, and tophi. Comorbidities and polypharmacy make the management of gout flares challenging in this population. Intra-articular corticosteroid injection remains the treatment of choice for accessible joints, oral prednisolone is preferred over low-dose colchicine, and non-steroidal anti-inflammatory drugs (NSAIDs) are best avoided...
December 6, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29214345/an-investigation-of-the-independent-risk-factors-that-differentiate-gout-from-pseudogout-in-patients-with-crystal-induced-acute-arthritis-a-cross-sectional-study
#8
Chayawee Muangchan, Thitirat Bhurihirun
OBJECTIVES: To identify independent risk factors that differentiate gout from pseudogout in patients that present with crystal-induced acute arthritis. METHODS: This cross-sectional study was conducted at Siriraj Hospital (Bangkok, Thailand) during the 25 May 2014-28 November 2014 study period. Patients who presented with crystal-induced acute arthritis were eligible for inclusion. Diagnosis of gout or pseudogout was made by microscopic visualization and analysis of crystals in synovial fluid...
December 6, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29210196/ultrasonographic-detection-of-double-contour-sign-and-hyperechoic-aggregates-for-diagnosis-of-gout-two-sites-examination-is-as-good-as-six-sites-examination
#9
Danveer Bhadu, Siddharth K Das, Archana Wakhlu, Urmila Dhakad, Meha Sharma
OBJECTIVE: To compare ultrasound-detected abnormalities, namely double contour sign (DCS) and hyperechoic aggregates (HAGs), at two sites (knee and first metatarsophalangeal [1st MTP] joints) versus six sites (knee joint, 1st MTP joint, radiocarpal joint, talar joint, patellar tendon and triceps tendon) in gout patients. METHODS: Forty-seven clinically diagnosed gout patients and 50 subjects (serum uric acid < 7 mg/dL) as controls were included. DCS was looked for at three articular cartilage sites (first metatarsal, tibiotalar and femoral condyle), whereas HAGs were looked for at one joint site (radiocarpal joint) and two tendon sites (patellar tendon and triceps tendon)...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29209066/interaction-of-complement-defence-collagens-c1q-and-mannose-binding-lectin-with-bmp-1-tolloid-like-proteinases
#10
Monique Lacroix, Agnès Tessier, Chantal Dumestre-Pérard, Sandrine Vadon-Le Goff, Evelyne Gout, Leena Bruckner-Tuderman, Dimitra Kiritsi, Alexander Nyström, Sylvie Ricard-Blum, Catherine Moali, David J S Hulmes, Nicole M Thielens
The defence collagens C1q and mannose-binding lectin (MBL) are immune recognition proteins that associate with the serine proteinases C1r/C1s and MBL-associated serine proteases (MASPs) to trigger activation of complement, a major innate immune system. Bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases (BTPs) are metalloproteinases with major roles in extracellular matrix assembly and growth factor signalling. Despite their different functions, C1r/C1s/MASPs and BTPs share structural similarities, including a specific CUB-EGF-CUB domain arrangement found only in these enzymes that mediates interactions with collagen-like proteins, suggesting a possible functional relationship...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208730/rituximab-for-corticosteroid-resistant-relapsing-igg4-related-intracranial-pachymeningitis-report-of-two-cases
#11
Arthur Mageau, Natalia Shor, Matthieu Fisselier, Jennifer Aboab, Augustin Lecler, Celeste Rebours, Homa Adle-Biassette, Olivier Gout, Romain Deschamps
IgG4-related disease is now recognised as an important cause of intracranial and spinal hypertrophic pachymeningitis. Treatment with corticosteroids generally leads to significant clinical improvement. We present two cases of IgG4 pachymeningitis unresponsive to corticosteroids who improved with rituximab.
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29207340/xanthine-oxidase-inhibitory-activity-of-natural-and-hemisynthetic-flavonoids-from-gardenia-oudiepe-rubiaceae-in%C3%A2-vitro-and-molecular-docking-studies
#12
M D Santi, M Paulino Zunini, B Vera, C Bouzidi, V Dumontet, A Abin-Carriquiry, R Grougnet, M G Ortega
Xanthine oxidase (XO), an enzyme widely distributed among mammalian tissues, is associated with the oxidation of xanthine and hypoxanthine to form uric acid. Reactive oxygen species are also released during this process, leading to oxidative damages and to the pathology called gout. Available treatments mainly based on allopurinol cause serious side effects. Natural products such as flavonoids may represent an alternative. Thus, a series of polymethoxyflavones isolated and hemisynthesized from the bud exudates of Gardenia oudiepe has been evaluated for in vitro XO inhibitory activity...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29204974/effects-of-discontinuation-of-urate-lowering-therapy-a-systematic-review
#13
Virginie Beslon, Perrine Moreau, Annabel Maruani, Hubert Maisonneuve, Bruno Giraudeau, Jean-Pascal Fournier
BACKGROUND: Urate-lowering therapy (ULT) is associated with low rates of adherence, leading to a potential risk of relapse of gouty arthritis, tophi, or urolithiasis. Our main aim was to identify the recurrence of gouty arthritis, tophi, or urolithiasis after discontinuation of ULT. Secondary aims included an assessment of ULT reintroduction rates and factors associated with relapse. METHODS: We conducted a systematic literature review of clinical studies investigating the effect of discontinuing any ULT (allopurinol, febuxostat, probenecid, sulfinpyrazone, benzbromarone) in adults on long-term therapy...
December 4, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29204859/improvement-in-diagnosis-and-treat-to-target-management-of-hyperuricemia-in-gout-results-from-the-gema-2-transversal-study-on-practice
#14
Fernando Perez Ruiz, Carlos A Sanchez-Piedra, Jesus T Sanchez-Costa, Mariano Andrés, Cesar Diaz-Torne, Mercedes Jimenez-Palop, Eugenio De Miguel, Carmen Moragues, Francisca Sivera
INTRODUCTION: The objective of the study was to evaluate changes regarding main European League Against Rheumatism (EULAR) recommendations on diagnosis and treatment of gout compared to a previous assessment. METHODS: The GEMA-2 (Gout Evaluation and MAnagement) is a transversal assessment of practice for gout by rheumatologists. Main outcome variables were improvement of the previous GEMA assessment regarding the rate of crystal-proven diagnosis and that reaching therapeutic serum urate target below 6 mg/dl at last visit...
December 4, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29204266/pegloticase-in-gout-treatment-safety-issues-latest-evidence-and-clinical-considerations
#15
REVIEW
Allison Guttmann, Svetlana Krasnokutsky, Michael H Pillinger, Adey Berhanu
Gout is a common rheumatic condition, with increasing prevalence in recent decades. The mainstay of treatment for gout is oral urate-lowering therapy (ULT), typically with xanthine oxidase inhibitors (XOIs). Unfortunately, a proportion of patients have persistent gout that is refractory to ULT. Pegloticase, a recombinant pegylated uricase, has been approved by the US Food and Drug Administration for the treatment of refractory gout. However, concern has been raised regarding the risk of infusion reactions, which are now understood to be largely due to the development of antipegloticase antibodies...
December 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29201931/colchicine-induced-hepatotoxicity
#16
Collette E Abbott, Ruliang Xu, Samuel H Sigal
Drug-induced injury (DILI) is a frequent cause of abnormal liver tests and a leading cause of liver failure in the United States. Colchicine has long been used as a systemic anti-inflammatory agent for treatment of gout by inhibiting mitotic activity and neutrophil function. We present the first case of colchicine-induced hepatoxicity, supported by histopathologic findings characteristic of colchicine-induced injury and resolution of liver enzyme abnormalities after its discontinuation. Colchicine-associated DILI has implications for the evaluation of patients with abnormal liver tests and gout, especially for patients with alcoholism and non-alcoholic fatty liver disease, in whom there is an increased incidence of gout...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29199508/wrist-inflammation-a-retrospective-comparison-between-septic-and-non-septic-arthritis
#17
Gavrielle Kang, Mabel Q H Leow, Shian-Chao Tay
This study aims to identify differences in demographics, clinical and laboratory data between wrist septic arthritis and non-septic arthritis in patients admitted for wrist inflammation. A retrospective review of inpatients from May 2012 to April 2015 was conducted. Seventy-seven patients were included. Non-septic arthritis patients were more likely to have chronic kidney disease, pre-existing gout, or both. All septic arthritis patients had normal serum uric acid levels, and two or more raised inflammatory markers (white cell count, C-reactive protein, erythrocyte sedimentation rate)...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29198878/medication-adherence-among-patients-with-gout-a-systematic-review-and-meta-analysis
#18
REVIEW
Lieke E J M Scheepers, Marloes van Onna, Coen D A Stehouwer, Jasvinder A Singh, Ilja C W Arts, Annelies Boonen
OBJECTIVE: In the management of chronic gout, a large proportion of patients need long-term management with urate lowering therapy (ULT). This study reviews medication adherence to ULT and summarizes factors associated with adherence. METHODS: We performed a systematic literature search for studies on adherence to ULT among gout patients in PubMed, Embase, CINAHL, and PsycINFO. We conducted meta-analysis, with a random effect model, for the studies reporting the proportion of patients considered adherent to at least 80% of prescribed medication or time taken...
October 7, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29196385/characteristic-and-outcome-of-psoriatic-arthritis-patients-with-hyperuricemia
#19
Roa'A AlJohani, Ari Polachek, Justine Yang Ye, Vinod Chandran, Dafna D Gladman
OBJECTIVE: To determine the characteristics of patients with psoriatic arthritis (PsA) who have hyperuricemia (HUC) and their outcomes, especially cardiovascular (CVD) and kidney diseases. METHODS: Patients have been followed prospectively at the PsA clinic according to a standard protocol at 6- to 12-month intervals. We defined HUC in men > 450 μmol/l or women > 360 μmol/l. We matched patients with HUC based on sex and age ± 5 years with normal uric acid patients...
December 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29194109/crystalline-arthropathy-and-bone-health
#20
Ian Chang, David Gazeley
PURPOSE OF REVIEW: The purpose of this review is to provide insight on the proposed association between crystal arthritis and bone health. Crystal arthritis is the most common type of inflammatory arthritis, and fractures contribute to significant morbidity and mortality, therefore, the relationship between the two is of clinical importance. RECENT FINDINGS: There have been variable findings regarding hyperuricemia, low bone density and risk of fracture. A recent systematic review and meta-analysis of available literature showed a correlation between increased serum uric acid and lower risk of fracture...
November 30, 2017: Current Opinion in Rheumatology
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