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https://www.readbyqxmd.com/read/29470212/risk-of-heart-related-death-from-gout-medication
#1
Diane S Aschenbrenner
No abstract text is available yet for this article.
March 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29466287/comparison-of-inhibitory-capacities-of-6-8-and-10-gingerols-shogaols-on-the-canonical-nlrp3-inflammasome-mediated-il-1%C3%AE-secretion
#2
Su-Chen Ho, Yi-Huang Chang
Endogenous noninfectious substances that mediate the nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation and interleukin (IL)-1β secretion causes inappropriate sterile inflammation and is implicated in the pathogenesis of several chronic diseases, such as type 2 diabetes mellitus, gout, atherosclerosis and Alzheimer's disease. Consequently, dietary phytochemicals exhibiting capacities to suppress canonical NLRP3 inflammasome-mediated IL-1β secretion can be a reliable supplement to prevent such diseases...
February 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29465872/-acid-uric-key-player-in-a-recently-recognized-devastating-nephropathy-and-in-the-development-of-chronic-kidney-disease
#3
Antoine Humbert, Fabien Stucker
Uric acid has been known since long ago for its implication in gout and in certain kinds of nephrolithiasis. However, its role in models of acute and chronic nephropathies has been the focus of many new developments. The so called Mesoamerican nephropathy is a devastating disease that has caused more than 20'000 deaths in central America these last few years among sugarcane workers. Acid uric could play a key role in its physiopathology. Moreover, acid uric tends to be recognized as an independent factor of development and progression in chronic kidney disease, opening a way for new therapeutic targets...
February 21, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29465359/socio-economic-inequalities-in-occurrence-and-health-care-costs-in-rheumatic-and-musculoskeletal-diseases-results-from-a-spanish-population-based-study-including-1-9-million-persons
#4
Polina Putrik, Sofia Ramiro, Juan F Orueta, Andras Keszei, Edurne Alonso Moran, Roberto Nuño Solinis, Annelies Boonen
OBJECTIVES: To explore and compare the impact of socio-economic deprivation on the occurrence of the major rheumatic and musculoskeletal diseases (RMDs) and health care costs. METHODS: Data on diagnoses, socio-demographics and health care costs of the entire adult population of the Basque Country (Spain) was used. Area deprivation index included five categories (1 to 5 (most deprived)). Cost categories included primary and specialist care, emergency room, hospitalisations, and drug prescriptions...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29464350/nipa-like-domain-containing-1-is-a-novel-tumor-promoting-factor-in-oral-squamous-cell-carcinoma
#5
Tomonori Sasahira, Yukiko Nishiguchi, Miyako Kurihara-Shimomura, Chie Nakashima, Hiroki Kuniyasu, Tadaaki Kirita
PURPOSE: In our previous global gene expression analysis, we identified NIPA-like domain containing 1 (NIPAL1), which encodes a magnesium transporter, as one of the most overexpressed genes in recurrent oral squamous cell carcinoma (OSCC). Although has been NIPAL1 linked with gout pathogenesis, little is known about its expression and function in human malignancies. METHODS: In this study, we examined NIPAL1 expression in 192 cases of OSCC by immunohistochemistry and performed a functional analysis of human OSCC cells...
February 20, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29463518/relationship-between-serum-urate-concentration-and-clinically-evident-incident-gout-an-individual-participant-data-analysis
#6
Nicola Dalbeth, Amanda Phipps-Green, Christopher Frampton, Tuhina Neogi, William J Taylor, Tony R Merriman
OBJECTIVES: To provide estimates of the cumulative incidence of gout according to baseline serum urate. METHODS: Using individual participant data from four publicly available cohorts (Atherosclerosis Risk in Communities Study, Coronary Artery Risk Development in Young Adults Study, and both the Original and Offspring cohorts of the Framingham Heart Study), the cumulative incidence of clinically evident gout was calculated according to baseline serum urate category...
February 20, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29461958/gout-in-duke-federico-of-montefeltro-1422-1482-a-new-pearl-of-the-italian-renaissance
#7
Antonio Fornaciari, Valentina Giuffra, Emanuele Armocida, Davide Caramella, Frank J Rühli, Francesco Maria Galassi
The article examines the truthfulness of historical accounts claiming that Renaissance Duke Federico of Montefeltro (1422-1482) suffered from gout. By direct paleopathological assessment of the skeletal remains and by the philological investigation of historical and documental sources, primarily a 1461 handwritten letter by the Duke himself to his personal physician, a description of the symptoms and Renaissance therapy is offered and a final diagnosis of gout is formulated. The Duke's handwritten letter offers a rare testimony of ancient clinical self-diagnostics and Renaissance living-experience of gout...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29457379/levels-of-cytokines-and-micrornas-in-individuals-with-asymptomatic-hyperuricemia-and-ultrasonographic-findings-of-gout-a-bench-to-bedside-approach
#8
Irving O Estevez-Garcia, Selma Gallegos-Nava, Erika Vera-Pérez, Luis H Silveira, Lucio Ventura-Ríos, Gonzalo Vancini, Cristina Hernández-Díaz, Fausto Sánchez-Muñoz, Martha A Ballinas-Verdugo, Marwin Gutierrez, Carlos Pineda, Pedro Rodriguez-Henriquez, Diana Castillo-Martínez, Luis M Amezcua-Guerra
OBJECTIVE: To assess potential associations among serum cytokines and microRNA (miR) levels with ultrasound (US) findings suggestive of urate deposits in chronic asymptomatic hyperuricemia and gout. METHODS: All participants underwent musculoskeletal US and measurements of serum IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IFN-γ, TNF, MCP-1, and ENA-78, as well as miR-146a, miR-155, and miR-223 levels. RESULTS: Thirty individuals with asymptomatic hyperuricemia, 31 normouricemic controls, and 30 gouty patients were included...
February 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29453348/abcg2-contributes-to-the-development-of-gout-and-hyperuricemia-in-a-genome-wide-association-study
#9
Chung-Jen Chen, Chia-Chun Tseng, Jeng-Hsien Yen, Jan-Gowth Chang, Wen-Cheng Chou, Hou-Wei Chu, Shun-Jen Chang, Wei-Ting Liao
Although many genome-wide association studies (GWASs) of hyperuricemia or gout have been reported, the related genetic factors and the mechanisms from hyperuricemia to gouty attack remain unclear. This study aimed to identify genetic factors and pathogenesis of gout from hyperuricemia by genome-wide association study (GWAS). 747 gout patients, 747 hyperuricemia and 2071 age-matched controls were recruited and analyzed with Affymetrix 650 K chip to find the related genetic variants. The functions of the related genes were investigated in an endothelial cell (EC) with urate crystal stimulation...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452983/orchestration-of-nlrp3-inflammasome-activation-by-ion-fluxes
#10
REVIEW
Tao Gong, Yanqing Yang, Tengchuan Jin, Wei Jiang, Rongbin Zhou
The assembly of the NLRP3 inflammasome can promote the release of IL-1β/IL-18 and initiate pyroptosis. Accordingly, the dysregulation of NLRP3 inflammasome activation is involved in a variety of human diseases, including gout, diabetes, and Alzheimer's disease. NLRP3 can sense a variety of structurally unrelated pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) to trigger inflammation, but the unifying mechanism of NLRP3 activation is still poorly understood. Increasing evidence suggests that intracellular ions, such as K + , Ca 2+ , and Cl - , have a significant role in NLRP3 inflammasome activation...
February 13, 2018: Trends in Immunology
https://www.readbyqxmd.com/read/29450849/impaired-arterial-responsiveness-in-untreated-gout-patients-compared-with-healthy-non-gout-controls-association-with-serum-urate-and-c-reactive-protein
#11
Svetlana Krasnokutsky, Aaron Garza Romero, Daisy Bang, Virginia C Pike, Binita Shah, Talia F Igel, Irina Dektiarev, Yu Guo, Judy Zhong, Stuart D Katz, Michael H Pillinger
To determine whether arterial responsiveness is impaired among patients with gout, and whether arterial responsiveness inversely correlates with serum urate and inflammatory measures. This is a cross-sectional study of untreated gout subjects (n = 34) and non-gout healthy controls (n = 64). High-resolution dynamic ultrasound-measured flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) assessed endothelium-dependent and endothelium-independent arterial responsiveness respectively. Serum urate (sUA) and high-sensitivity C-reactive protein (hsCRP) were measured in the gout group, and correlated with FMD and NMD responses...
February 15, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29449500/the-cost-effectiveness-of-biannual-serum-urate-su-monitoring-after-reaching-target-in-gout-a-health-economic-analysis-comparing-su-monitoring
#12
Philip C Robinson, Nicola Dalbeth, Peter Donovan
OBJECTIVE: The 2012 American College of Rheumatology gout management guidelines recommend monitoring serum urate (SU) every 6 months after target SU has been achieved. Our objective was to determine through modeling whether this testing would be cost-effective, considering financial cost, quality of life, and estimated change in adherence. METHODS: A cost-utility analysis was completed with a 3-arm model: (1) no regular urate monitoring; (2) annual urate monitoring; and (3) biannual urate monitoring...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29447370/management-of-gout-by-uk-rheumatologists-a-british-society-for-rheumatology-national-audit
#13
Edward Roddy, Jon Packham, Karen Obrenovic, Ali Rivett, Joanna M Ledingham
Objectives: To assess the concordance of gout management by UK rheumatologists with evidence-based best-practice recommendations. Methods: Data were collected on patients newly referred to UK rheumatology out-patient departments over an 8-week period. Baseline data included demographics, method of diagnosis, clinical features, comorbidities, urate-lowering therapy (ULT), prophylaxis and blood tests. Twelve months later, the most recent serum uric acid level was collected...
February 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29446654/hypouricaemic-effects-of-yogurt-containing-lactobacillus-gasseri-pa-3-in-patients-with-hyperuricaemia-and-or-gout-a-randomized-double-blind-placebo-controlled-study
#14
Hisashi Yamanaka, Atsuo Taniguchi, Hiroshi Tsuboi, Hiroshi Kano, Yukio Asami
PURPOSE: Lactobacillus gasseri PA-3 (PA-3) has been previously shown to decrease serum uric acid (SUA) levels in subjects with increased SUA. In this study, we investigated whether PA-3 is also capable of decreasing SUA levels in patients with hyperuricaemia and/or gout. METHODS: Twenty-five patients with hyperuricaemia and/or gout completed this study. Urate-lowering drugs were discontinued for 12 weeks (week -4 to week 8). After flushing of urate-lowering drugs for 4 weeks (week 0), patients were randomized equally to receive diets containing yogurt beverages with PA-3 or without PA-3 for a duration of 8 weeks (week 8)...
February 15, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29442150/ultrasound-scans-and-dual-energy-ct-identify-tendons-as-preferred-anatomical-location-of-msu-crystal-depositions-in-gouty-joints
#15
Yuan Yuan, Chang Liu, Xi Xiang, Tong-Ling Yuan, Li Qiu, Yi Liu, Yu-Bin Luo, Y Zhao, Martin Herrmann
OBJECTIVE: The present study was performed to localize the articular deposition of monosodium urate (MSU) crystal in joints. We compare the detection efficiencies of dual-energy CT (DECT) and ultrasound scans. METHODS: Analyses by DECT and ultrasound were performed with 184 bilateral joints of the lower limbs of 54 consecutive gout patients. All joints were categorized into (1) knee, (2) ankle, (3) MTP1, and (4) MTP2, and sorted into those with and those without detectable MSU deposition...
February 13, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29441566/aneustat-omn54-has-aerobic-glycolysis-inhibitory-activity-and-also-immunomodulatory-activity-as-indicated-by-a-first-generation-pdx-prostate-cancer-model
#16
Sifeng Qu, Hui Xue, Xin Dong, Dong Lin, Rebecca Wu, Noushin Nabavi, Colin C Collins, Martin E Gleave, Peter W Gout, Yuzhuo Wang
Aneustat (OMN54) is a multivalent, botanical anticancer candidate therapeutic. A recent Phase-I clinical trial has indicated that it is well tolerated by patients and has immunomodulatory activity. In the present study, using in vitro and in vivo prostate cancer models, we investigated Aneustat with regard to effects on (i) cancer-generated immunosuppression based on aerobic glycolysis leading to acidification of the tumor microenvironment, and (ii) immune-related processes such as macrophage differentiation and shifts in the intratumoral levels of host immune cells...
February 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29438607/improved-gout-outcomes-in-primary-care-using-a-novel-disease-management-program-a-pilot-study
#17
David Bulbin, Alfred E Denio, Andrea Berger, Jason Brown, Carson Maynard, Tarun Sharma, H Lester Kirchner, William T Ayoub
OBJECTIVE: To pilot a primary care gout management improvement intervention. METHODS: Two large primary care sites were selected: one underwent the intervention, the other, a control, underwent no intervention. The intervention consisted of: engagement of intervention site staff, surveys of provider performance improvement preferences, and onsite live and enduring online education. Electronic Health Record reminders were constructed. Both the intervention and control sites had 3 quality measures assessed monthly: percent of gout patients treated with urate lowering therapy, percent of treated patients monitored with serum urate, and percent of treated patients at target serum urate ≤ 6...
February 13, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29438436/assessment-of-coronary-vascular-function-with-cardiac-pet-in-relation-to-serum-uric-acid
#18
Seoyoung C Kim, Nishant R Shah, James R Rogers, Courtney F Bibbo, Marcelo F Di Carli, Daniel H Solomon
BACKGROUND: Elevated serum uric acid (SUA) levels have been independently associated with cardiovascular disease. Stress myocardial perfusion positron emission tomography (PET) allows for measurement of absolute myocardial blood flow (MBF) and quantification of global left ventricular coronary flow reserve (CFR). A CFR <2.0 is considered impaired coronary vascular function, and it is associated with increased cardiovascular risk. We evaluated the relationship between SUA and PET-measured markers of coronary vascular function...
2018: PloS One
https://www.readbyqxmd.com/read/29437585/mr-phewas-exploring-the-causal-effect-of-sua-level-on-multiple-disease-outcomes-by-using-genetic-instruments-in-uk-biobank
#19
Xue Li, Xiangrui Meng, Athina Spiliopoulou, Maria Timofeeva, Wei-Qi Wei, Aliya Gifford, Xia Shen, Yazhou He, Tim Varley, Paul McKeigue, Ioanna Tzoulaki, Alan F Wright, Peter Joshi, Joshua C Denny, Harry Campbell, Evropi Theodoratou
OBJECTIVES: We aimed to investigate the role of serum uric acid (SUA) level in a broad spectrum of disease outcomes using data for 120 091 individuals from UK Biobank. METHODS: We performed a phenome-wide association study (PheWAS) to identify disease outcomes associated with SUA genetic risk loci. We then implemented conventional Mendelian randomisation (MR) analysis to investigate the causal relevance between SUA level and disease outcomes identified from PheWAS...
February 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29435850/managing-gout-in-the-patient-with-renal-impairment
#20
Eliseo Pascual, Francisca Sivera, Mariano Andrés
Hyperuricaemia is an independent risk factor for renal function decline. Evidence is emerging that urate-lowering therapy might be beneficial in subjects with renal impairment. We  review the association between renal impairment and gout, some of the related pathogenic processes and the possible impact of gout treatment on the progression of renal impairment. Nevertheless, the management of gout is more complex in the presence of chronic kidney disease. The main aim of gout therapy is to fully dissolve the urate crystals, thus curing the disease...
February 13, 2018: Drugs & Aging
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