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https://www.readbyqxmd.com/read/29054295/diagnostic-accuracy-of-ultrasound-in-patients-with-gout-a-meta-analysis
#1
REVIEW
Young Ho Lee, Gwan Gyu Song
OBJECTIVE: This study aimed to evaluate the diagnostic performance of ultrasound (US) for patients with gout. METHODS: We searched the Medline, Embase, Pubmed, and Cochrane Library databases, and performed a meta-analysis of the diagnostic accuracy of US according to the double contour sign, tophus, snowstorm, or bony erosion in patients with gout. RESULTS: In total, 11 studies including 938 patients with gout, and 788 controls (patients with nongout inflammatory arthritis) were available for the meta-analysis...
September 28, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29053564/gout-keratitis-a-case-of-peripheral-ulcerative-keratitis-secondary-to-gout-with-a-review-of-the-literature
#2
Amirfarbod Yazdanyar, Allison E Rizzuti, Elzbieta Mechel, Ksenia Denisova, Douglas R Lazzaro
PURPOSE: To report a case of peripheral ulcerative keratitis secondary to gout. METHODS: A 41-year-old man with a history of severe gout disease presented with pain and redness of the right eye. Physical examination revealed 2 areas of peripheral corneal thinning with overlying epithelial defects. Adjacent to these areas, reflective crystals were identified in the corneal stroma. Anterior segment optical coherence tomography demonstrated stromal corneal deposits...
October 17, 2017: Cornea
https://www.readbyqxmd.com/read/29051626/crystal-arthritis-febuxostat-reduces-synovitis-in-early-gout
#3
Joanna Collison
No abstract text is available yet for this article.
October 20, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29049401/risk-factors-for-intrahepatic-and-extrahepatic-cholangiocarcinoma-in-the-united-states-a-population-based-study-in-seer-medicare
#4
Jessica L Petrick, Baiyu Yang, Sean F Altekruse, Alison L Van Dyke, Jill Koshiol, Barry I Graubard, Katherine A McGlynn
OBJECTIVES: Intrahepatic (ICC) and extrahepatic (ECC) cholangiocarcinomas are rare tumors that arise from the epithelial cells of the bile ducts, and the etiology of both cancer types is poorly understood. Thus, we utilized the Surveillance, Epidemiology, and End Results (SEER)-Medicare resource to examine risk factors and novel preexisting medical conditions that may be associated with these cancer types. METHODS: Between 2000 and 2011, 2,092 ICC and 2,981 ECC cases and 323,615 controls were identified using the SEER-Medicare database...
2017: PloS One
https://www.readbyqxmd.com/read/29049247/increased-circulating-th22-cells-in-patients-with-acute-gouty-arthritis-a-consort-compliant-article
#5
Guangcheng Luo, Tingting Yi, Guoyuan Zhang, Xiaolan Guo, Xingliang Jiang
BACKGROUND: T-helper 22 (Th22) cells are involved in host immunity against pathogen invasion and have been implicated in the pathogenesis of inflammatory diseases. However, the roles of Th22 cells in acute gouty arthritis remain unclear. METHODS: A case-control study was employed to illustrate the clinical significance of Th22 cells in acute gouty arthritis. In this study, 27 patients with acute gouty arthritis, 22 patients with intercritical gout (IG), and 20 healthy controls were recruited, and peripheral blood cells and plasma were collected for the detection of Th22, Th17, and Th1 cells, and plasma interleukin (IL)-22...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29047359/thiazides-in-the-management-of-hypertension-in-older-adults-a-systematic-review
#6
REVIEW
Christina Sommerauer, Neha Kaushik, Adrine Woodham, Anna Renom-Guiteras, Yolanda V Martinez, David Reeves, Ilkka Kunnamo, Thekraiat Al Qur An, Steffen Hübner, Andreas Sönnichsen
BACKGROUND: Thiazides are commonly prescribed to older people for the management of hypertension. The objective of this study was to identify the evidence on the risks and benefits of their use among adults aged ≥65 years and to develop recommendations to reduce potentially inappropriate use. METHODS: Systematic review (SR) of the literature covering six databases. We applied a staged search approach, where each search was undertaken only if the previous one did not yield high quality results...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29047331/-i-can-t-bend-it-and-it-hurts-like-mad-direct-observation-of-gout-consultations-in-routine-primary-health-care
#7
Anthony Dowell, Caroline Morris, Lindsay Macdonald, Maria Stubbe
BACKGROUND: Gout is the most common form of inflammatory arthritis and is associated with considerable co-morbidity. It is usually managed in the primary care setting with a combination of lifestyle modification and pharmacological therapy. This study describes patterns of communication about gout observed in interactions between patients and primary care practitioners during routine consultations. METHODS: Secondary analysis of video-recordings of individual healthcare consultations between patients and a range of primary care practitioners (including general practitioners, practice nurses, podiatrists and dietitians) from an archived database...
October 18, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/29046164/colchicine-a-review-about-chemical-structure-and-clinical-using
#8
Hourieh Alkadi, Mohamad Jowad Khubeiz
For many years, colchicine has been used for therapeutic purposes and has been given considerable attention because of its association with tubulin and inhibition of small tubular polymerization. Colchicine is an alkaloids extracted from the colchicum autumnale plant, and it contains a molecular formula C22H25NO6, and it consists of three rings. Many studies have concerned with structural changes, in order to increase their pharmacological effectiveness and to reduce the side effects of toxicity arising from it...
October 17, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29045037/autoantibodies-targeting-ficolin-2-in-systemic-lupus-erythematosus-patients-with-active-nephritis
#9
Sophie Colliard, Noémie Jourde-Chiche, Giovanna Clavarino, Françoise Sarrot-Reynauld, Evelyne Gout, Alban Deroux, Mélanie Fougere, Nathalie Bardin, Laurence Bouillet, Jean-Yves Cesbron, Nicole M Thielens, Chantal Dumestre-Pérard
OBJECTIVE: Systemic lupus erythematosus (SLE) is a multi-system inflammatory disease characterized by production of various autoantibodies. The aim of this study was to investigate the presence of anti-ficolin-2 antibodies in SLE patients and to evaluate the association between the levels of these autoantibodies, clinical manifestations, and disease activity. METHODS: This is a comparative study using a cohort of 165 SLE patients and 48 healthy subjects. SLE patients were further divided into two groups, with "low disease activity" (SLEDAI score ≤ 4, n = 88) and with "high disease activity" (SLEDAI score > 4, n = 77)...
October 17, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29042386/effectiveness-of-an-electronic-patient-centred-self-management-tool-for-gout-sufferers-a-cluster-randomised-controlled-trail-protocol
#10
Richard O Day, Lauren J Frensham, Amy D Nguyen, Melissa T Baysari, Eindra Aung, Annie Y S Lau, Nicholas Zwar, Jennifer Reath, Tracey Laba, Ling Li, Andrew McLachlan, William B Runciman, Rachelle Buchbinder, Robyn Clay-Williams, Enrico Coiera, Jeffrey Braithwaite, H Patrick McNeil, David J Hunter, Kevin J Pile, Ian Portek, Kenneth Mapson WIlliams, Johanna I Westbrook
INTRODUCTION: Gout is increasing despite effective therapies to lower serum urate concentrations to 0.36 mmol/L or less, which, if sustained, significantly reduces acute attacks of gout. Adherence to urate-lowering therapy (ULT) is poor, with rates of less than 50% 1 year after initiation of ULT. Attempts to increase adherence in gout patients have been disappointing. We aim to evaluate the effectiveness of use of a personal, self-management, 'smartphone' application (app) to achieve target serum urate concentrations in people with gout...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29041963/is-gout-a-risk-equivalent-to-diabetes-for-stroke-and-myocardial-infarction-a-retrospective-claims-database-study
#11
Jasvinder A Singh, Rekha Ramachandaran, Shaohua Yu, Shuo Yang, Fenglong Xie, Huifeng Yun, Jie Zhang, Jeffrey R Curtis
BACKGROUND: Gout is a risk factor for cardiovascular disease, but associations with specific cardiovascular outcomes, myocardial infarction (MI), and stroke are unclear. Our objective in the present study was to assess whether gout is as strong a risk factor as diabetes mellitus (DM) for incident MI and incident stroke. METHODS: In this retrospective study, we used U.S. claims data from 2007 to 2010 that included a mix of private and public health plans. Four mutually exclusive cohorts were identified: (1) DM only, (2) gout only, (3) gout and DM, and (4) neither gout nor DM...
October 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29040733/decreased-incidence-of-gout-in-diabetic-patients-using-pioglitazone
#12
Sheng-Wen Niu, Kai-Ting Chang, Hugo You-Hsien Lin, I-Ching Kuo, Yu-Han Chang, Yu-Han Chen, Chi-Chih Hung, Yi-Wen Chiu, Shang-Jyh Hwang
Objective: The incidence and prevalence of gout are increasing, but the management is poor. Considering the increased prevalence of gout in the diabetic population, this study evaluated the effects of pioglitazone, an insulin resistance inhibitor, on the incidence of gout in the diabetic population. Methods: We used data from the National Health Insurance program in Taiwan. The pioglitazone cohort contained 30 100 patients and each patient was age and sex matched with three non-pioglitazone users who were randomly selected from the diabetic population...
October 10, 2017: Rheumatology
https://www.readbyqxmd.com/read/29034191/pharmacological-properties-of-salvia-officinalis-and-its-components
#13
Ahmad Ghorbani, Mahdi Esmaeilizadeh
Salvia officinalis (Sage) is a plant in the family of Labiatae/Lamiaceae. It is native to Middle East and Mediterranean areas, but today has been naturalized throughout the world. In folk medicine, S. officinalis has been used for the treatment of different kinds of disorders including seizure, ulcers, gout, rheumatism, inflammation, dizziness, tremor, paralysis, diarrhea, and hyperglycemia. In recent years, this plant has been a subject of intensive studies to document its traditional use and to find new biological effects...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033576/lumbar-spinal-stenosis-attributable-to-tophaceous-gout-case-report-and-review-of-the-literature
#14
Wei Wang, Qingbo Li, Lei Cai, Weijun Liu
OBJECTIVES: Tophaceous gout seldom affects the axial skeleton. Symptoms vary according to the differential localization of urate deposits and the diagnosis is often delayed. Here, we report an unusual case of lumbar spinal stenosis caused by extradural tophaceous deposits. METHODS: We retrospectively reviewed a case of a patient with tophaceous gout of the lumbar spine and reviewed the relevant literature. RESULTS: A 62-year-old man with a 2-year history of lower back pain and a 3-month history of lower limb radiation pain and intermittent claudication was admitted...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29029210/lesinurad-monotherapy-in-gout-patients-intolerant-to-a-xanthine-oxidase-inhibitor-a-6-month-phase-3-clinical-trial-and-extension-study
#15
Anne-Kathrin Tausche, Rieke Alten, Nicola Dalbeth, Jeff Kopicko, Maple Fung, Scott Adler, Nihar Bhakta, Chris Storgard, Scott Baumgartner, Kenneth Saag
Objective: To investigate the efficacy and safety of lesinurad, a selective uric acid reabsorption inhibitor, in a 6 month, phase 3 clinical trial and extension study. Methods: Patients with gout who cannot take a xanthine oxidase inhibitor (XOI) and have serum uric acid (sUA) ⩾6.5 mg/dl were randomized to receive oral lesinurad (400 mg daily) or placebo. The primary endpoint was the proportion of patients with sUA <6.0 mg/dl at month 6. Safety assessments included treatment-emergent adverse events (TEAEs) and laboratory data...
September 23, 2017: Rheumatology
https://www.readbyqxmd.com/read/29028079/potency-on-lowering-serum-uric-acid-in-gout-patients-a-pooled-analysis-of-registrative-studies-comparing-febuxostat-vs-allopurinol
#16
M Cutolo, M A Cimmino, F Perez-Ruiz
OBJECTIVE: Hyperuricemia leading to urate crystal formation in tissues represents the pathophysiological mechanism of gout. Guidelines recommend a therapeutic target of serum urate concentration (sUA) <6 mg/dL, or even lower (≤5 mg/dL) in patients with large deposits. We conducted an analysis with the aim to achieve additional insights into the urate-lowering efficacy of two xanthine oxidase inhibitors, allopurinol and febuxostat. PATIENTS AND METHODS: This was a pooled analysis of phase III trials on allopurinol and febuxostat, including 4101 patients with gout and hyperuricemia...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026858/chemical-constitute-and-larvicidal-activity-of-fractions-of-ajuga-chamaecistus-tomentella-plant-against-malaria-vector-anopheles-stephensi
#17
Mahnaz Khanavi, Behnaz Najafi, Seyede Nargess Sadati, Mohammad Reza Abai, Hassan Vatandoost
BACKGRAND: The genus Ajuga, belongs to Lamiaceae family, is one of the exclusive subspecies in the flora of Iran. The plants of this genus are used traditionally for treatment of joints pain, gout, jaundice, and as insecticide. METHODS: larvicidal activity of methanol 80% extract and partition fractions of hexane, chloroform, and ethyl acetate obtained from aerial parts of Ajuga chamaecistus subspecies tomentella against malaria vector An. stephensi was evaluated...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29025161/generalized-finger-clubbing-reveals-the-cause-of-secondary-gout
#18
Kanon Jatuworapruk
No abstract text is available yet for this article.
July 26, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29025052/ultrasound-double-contour-sign-and-gout
#19
Y-H Chen, C-C Lu, C-C Chang
No abstract text is available yet for this article.
July 21, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29023487/triggers-of-acute-attacks-of-gout-does-age-of-gout-onset-matter-a-primary-care-based-cross-sectional-study
#20
Abhishek Abhishek, Ana M Valdes, Wendy Jenkins, Weiya Zhang, Michael Doherty
OBJECTIVES: To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute attacks of gout. METHODS: Individuals with gout were asked to fill a questionnaire enquiring about triggers that precipitated their acute gout attacks. Binary logistic regression was used to compute odds ratio (OR) and 95% confidence intervals (CI) to examine the association between having ≥1 self-reported trigger of acute gout and disease and demographic risk factors and to adjust for covariates...
2017: PloS One
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