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https://www.readbyqxmd.com/read/28818095/frequency-distribution-and-immunologic-nature-of-infusion-reactions-in-subjects-receiving-pegloticase-for-chronic-refractory-gout
#1
Leonard H Calabrese, Arthur Kavanaugh, Anthony E Yeo, Peter E Lipsky
BACKGROUND: To assess frequency and distribution of infusion reactions (IRs) in responders and nonresponders in randomized clinical trials (RCTs) of intravenous pegloticase and the utility of the National Institute of Allergy and Infectious Disease/Food and Allergy and Anaphylaxis Network (NIAID/FAAN) criteria for identifying anaphylaxis in subjects experiencing IRs. METHODS: IRs from two RCTs of pegloticase were evaluated and categorized as anaphylaxis, hypersensitivity, or other...
August 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28818081/what-makes-gouty-inflammation-so-variable
#2
REVIEW
Robert Terkeltaub
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem. Flares can be complex and expensive to treat, partly due to the frequent comorbidities. Unmet needs in gout management are more pressing given the markedly increasing gout flare hospital admission rates. In addition, chronic gouty arthritis can cause joint damage and functional impairment. This review addresses new knowledge on the basis for the marked, inherent variability of responses to deposited urate crystals, including the unpredictable and self-limited aspects of many gout flares...
August 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28816767/allopurinol-medication-adherence-as-a-mediator-of-optimal-outcomes-in-gout-management
#3
Brian W Coburn, Kayli A Bendlin, Harlan Sayles, Jane Meza, Cynthia L Russell, Ted R Mikuls
BACKGROUND: Patient and provider factors, including allopurinol medication adherence, affect gout treatment outcomes. OBJECTIVES: The aim of this study was to examine associations of patient and provider factors with optimal gout management. METHODS: Linking longitudinal health and pharmacy dispensing records to questionnaire data, we assessed patient and provider factors among 612 patients with gout receiving allopurinol during a recent 1-year period...
August 14, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28816765/the-needle-or-knife-pegloticase-for-refractory-crippling-gout-in-a-nonagenarian
#4
Noah Choi, Jeffrey Eickhoff, Michael Keith
No abstract text is available yet for this article.
August 14, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28812408/calcium-pyrophosphate-deposition-disease-a-frequent-finding-in-patients-with-long-standing-erosive-gout
#5
B Ankli, D Kyburz, A Hirschmann, T Hügle, T Manigold, C T Berger, T Daikeler
OBJECTIVE: To characterize patients with both monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals in their synovial fluid (SF). METHOD: Forty-nine gout patients with acute arthritis were included. Those patients with MSU crystals only in their SF were compared to those patients with both MSU and CPP crystals in their SF. RESULTS: A total of 36 out of 49 patients (73.5%) had only MSU crystals, whereas 13 out of 49 (26.5%) had both MSU and CPP crystals in their SF...
August 16, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28809954/the-burden-of-septic-arthritis-on-the-u-s-inpatient-care-a-national-study
#6
Jasvinder A Singh, Shaohua Yu
OBJECTIVE: To assess the health care burden of septic arthritis in the U.S. and examine the associated factors. METHODS: We used the U.S. Nationwide Emergency Department Sample (NEDS) data of patients hospitalized with septic arthritis as the primary diagnosis from 2009-12 to assess time-trends. Multivariable-adjusted models assessed demographics, comorbidity and hospital characteristics as potential predictors of duration of hospitalization, total hospital (inpatient and ED) charges and discharge to home...
2017: PloS One
https://www.readbyqxmd.com/read/28808190/cholesterol-crystal-embolization-following-plaque-rupture-a-systemic-disease-with-unusual-features
#7
Firas Ghanem, Deepthi Vodnala, Jagadeesh K Kalavakunta, Sridevi Durga, Noah Thormeier, Prem Subramaniyam, Scott Abela, George S Abela
Cholesterol crystal embolic (CCE) syndrome is often a clinically challenging condition that has a poor prognostic implication. It is a result of plaque rupture with release of cholesterol crystals into the circulation that embolize into various tissue organs. Plaque rupture seems to be triggered by an expanding necrotic core during cholesterol crystallization forming sharp tipped crystals that perforate and tear the fibrous cap. Embolizing cholesterol crystals then initiate both local and systemic inflammation that eventually lead to vascular fibrosis and obstruction causing symptoms that can mimic other vasculitic conditions...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28807230/global-identification-of-chemical-constituents-and-rat-metabolites-of-si-miao-wan-by-liquid-chromatography-electrospray-ionization-quadrupole-time-of-flight-mass-spectrometry
#8
Jin-Jin Lu, Xue-Wen Hu, Ping Li, Jun Chen
Si-Miao-Wan (SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-flight mass spectrometry (LC-Q-TOF/MS) method was established to identify the multiple constituents of SMW and its metabolites in rat biological samples after oral administration. A total of 48 compounds in SMW, including 21 alkaloids, 12 organic acids, 2 terpenes, 3 lactones, 2 phytosterols, and 8 other compounds, were tentatively characterized with the diagnostic-ion filtering strategy...
July 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28806836/-complication-of-an-elbow-prosthesis-screw-breakage-of-the-ulnar-cap-and-gout-arthropathy
#9
Marion Mühldorfer-Fodor, Thomas Pillukat, Jörg van Schoonhoven, Karl Josef Prommersberger
No abstract text is available yet for this article.
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28803339/dual-energy-computed-tomography-has-limited-diagnostic-sensitivity-for-short-term-gout
#10
Ertao Jia, Junqing Zhu, Wenhui Huang, Xiaoguang Chen, Juan Li
The aim of this study was to discuss the diagnostic value of dual-energy computed tomography (DECT) in patients with gout during different disease phases. Two hundred twenty-one patients (136 with gout and 85 with other arthritic diseases) were recruited to the study. Arthrosis pain was evaluated in all patients by DECT scans. We calculated the sensitivity and specificity of DECT for the diagnosis of gout, including the first onset period, less than 24 months period, and more than 24 months period. We then investigated the related risk factors of urate crystals volume in the foot...
August 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28801728/arctium-minus-crude-extract-presents-antinociceptive-effect-in-a-mice-acute-gout-attack-model
#11
Susana Paula Moreira Fischer, Indiara Brusco, Camila Camponogara, Mariana Piana, Henrique Faccin, Luciana Assis Gobo, Leandro Machado de Carvalho, Sara Marchesan Oliveira
Gout is a disorder that triggers a severe inflammatory reaction which generates episodes of intense pain and discomfort to the patient. Arctium minus (Hill) Bernh. (Asteraceae) is known as "burdock" and displays anti-inflammatory, antinociceptive, against rheumatic pain and radical-scavenging activities. Species of the genus Arctium have been used in assistant therapy of gout and other inflammatory processes. We investigated the antinociceptive and anti-edematogenic effects of the crude extract of A. minus seeds in an acute gout attack model induced by intra-articular injection of monosodium urate (MSU) crystals in adult male Swiss mice (25-30 g)...
August 11, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28797283/incident-gout-and-erectile-dysfunction-is-hyperuricaemia-the-elephant-in-the-room
#12
EDITORIAL
Abhishek Abhishek, Michael Doherty
The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have a 31% higher risk of erectile dysfunction than matched controls, although the absolute increase in risk is small. Of interest, the incidence of erectile dysfunction reported in this study is tenfold higher than those reported in nation-wide cohort studies from Taiwan. There is a need for further prospective cohort studies to examine the possible mechanistic association between gout, hyperuricaemia and erectile dysfunction...
August 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28797095/single-nucleotide-polymorphisms-associated-with-p2x7r-function-regulate-the-onset-of-gouty-arthritis
#13
Jin-Hui Tao, Miao Cheng, Jiang-Ping Tang, Xiao-Juan Dai, Yong Zhang, Xiang-Pei Li, Qin Liu, Ya-Ling Wang
BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1β (IL-1β) stimulated by monosodium urate (MSU) crystals. However, some hyperuricemia patients, even gouty patients with tophi in the joints, never experience gout attack, which indicates that pathogenic pathways other than MSU participate in the secretion of IL-1β in the pathogenesis of acute gouty arthritis. The ATP-P2X7R-IL-1β axis may be one of these pathways. OBJECTIVE: This study examines the role of Adenosine triphosphate (ATP) in the pathogenesis of gout and the association of ATP receptor (P2X7R) function with single nucleotide polymorphisms and gout arthritis...
2017: PloS One
https://www.readbyqxmd.com/read/28796049/tophaceous-gout-causing-lumbar-stenosis-a-case-report
#14
Huigen Lu, Jianming Sheng, Jiaping Dai, Xuqi Hu
RATIONALE: Gout in the spine is very rare. The clinical symptoms of the spinal gout are various and lack of specificity. The authors report a case of spinal gout causing lumbar stenosis. We never find such wide-invasive spinal gouty lesion in the published studies. PATIENT CONCERNS: A 68-year-old male had low back pain radiating to bilateral lower limbs, accompanying with intermittent claudication that lasted for 3 months and aggravated 5 days ago. DIAGNOSES: Spinal gout, lumbar stenosis...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28794514/discordant-american-college-of-physicians-and-international-rheumatology-guidelines-for-gout-management-consensus-statement-of-the-gout-hyperuricemia-and-crystal-associated-disease-network-g-can
#15
REVIEW
Nicola Dalbeth, Thomas Bardin, Michael Doherty, Frédéric Lioté, Pascal Richette, Kenneth G Saag, Alexander K So, Lisa K Stamp, Hyon K Choi, Robert Terkeltaub
In November 2016, the American College of Physicians (ACP) published a clinical practice guideline on the management of acute and recurrent gout. This guideline differs substantially from the latest guidelines generated by the American College of Rheumatology (ACR), European League Against Rheumatism (EULAR) and 3e (Evidence, Expertise, Exchange) Initiative, despite reviewing largely the same body of evidence. The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) convened an expert panel to review the methodology and conclusions of these four sets of guidelines and examine possible reasons for discordance between them...
August 10, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28793914/performance-of-gout-definitions-for-genetic-epidemiological-studies-analysis-of-uk-biobank
#16
Murray Cadzow, Tony R Merriman, Nicola Dalbeth
BACKGROUND: Many different combinations of available data have been used to identify gout cases in large genetic studies. The aim of this study was to determine the performance of case definitions of gout using the limited items available in multipurpose cohorts for population-based genetic studies. METHODS: This research was conducted using the UK Biobank Resource. Data, including genome-wide genotypes, were available for 105,421 European participants aged 40-69 years without kidney disease...
August 9, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28793879/septic-arthritis-significantly-increased-the-long-term-mortality-in-geriatric-patients
#17
Chia-Jung Wu, Chien-Cheng Huang, Shih-Feng Weng, Ping-Jen Chen, Chien-Chin Hsu, Jhi-Joung Wang, How-Ran Guo, Hung-Jung Lin
BACKGROUND: The elderly are predisposed to septic arthritis (SA) because of the aging nature and increasing comorbidities. SA may in turn increase the long-term mortality in the geriatric patients; however, it remains unclear. We conducted this prospective nationwide population-based cohort study to clarify this issue. METHODS: Using Taiwan National Health Insurance Research Database (NHIRD), we identified 1667 geriatric participants (≥ 65 years) with SA and 16,670 geriatric participants without SA matched at a ratio of 1:10 by age, sex, and index date between 1999 and 2010...
August 9, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28793332/stromal-cell-markers-are-differentially-expressed-in-the-synovial-tissue-of-patients-with-early-arthritis
#18
Ivy Y Choi, Olga N Karpus, Jason D Turner, Debbie Hardie, Jennifer L Marshall, Maria J H de Hair, Karen I Maijer, Paul P Tak, Karim Raza, Jörg Hamann, Christopher D Buckley, Danielle M Gerlag, Andrew Filer
INTRODUCTION: Previous studies have shown increased expression of stromal markers in synovial tissue (ST) of patients with established rheumatoid arthritis (RA). Here, ST expression of stromal markers in early arthritis in relationship to diagnosis and prognostic outcome was studied. METHODS: ST from 56 patients included in two different early arthritis cohorts and 7 non-inflammatory controls was analysed using immunofluorescence to detect stromal markers CD55, CD248, fibroblast activation protein (FAP) and podoplanin...
2017: PloS One
https://www.readbyqxmd.com/read/28791038/association-genetics-in-plant-pathogens-minding-the-gap-between-the-natural-variation-and-the-molecular-function
#19
Anne Genissel, Johann Confais, Marc-Henri Lebrun, Lilian Gout
No abstract text is available yet for this article.
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28785346/asymptomatic-papules-and-subcutaneous-nodules-as-first-sign-of-gout
#20
Serena Gianfaldoni, Roberto Gianfaldoni, Georgi Tchernev, Uwe Wollina, Claudio Guarneri, Massimo Fioranelli, Maria Grazia Roccia, Torello Lotti
The authors describe a case report characterised by asymptomatic papules and non-tender subcutaneous nodules as the isolated manifestations of gout.
July 25, 2017: Open Access Macedonian Journal of Medical Sciences
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