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https://www.readbyqxmd.com/read/28345493/genetic-risk-scores-sex-and-dietary-factors-interact-to-alter-serum-uric-acid-trajectory-among-african-american-urban-adults
#1
May A Beydoun, Jose-Atilio Canas, Marie T Fanelli-Kuczmarski, Salman M Tajuddin, Michele K Evans, Alan B Zonderman
Serum uric acid (SUA), a causative agent for gout among others, is affected by both genetic and dietary factors, perhaps differentially by sex. We evaluated cross-sectional (SUAbase) and longitudinal (SUArate) associations of SUA with a genetic risk score (GRS), diet and sex. We then tested the interactive effect of GRS, diet and sex on SUA. Longitudinal data on 766 African-American urban adults participating in the Healthy Aging in Neighborhood of Diversity across the Lifespan study were used. In all, three GRS for SUA were created from known SUA-associated SNP (GRSbase (n 12 SNP), GRSrate (n 3 SNP) and GRStotal (n 15 SNP))...
March 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28341808/protein-coalation-a-redox-regulated-protein-modification-by-coenzyme-ain-mammalian-cells
#2
Yugo Tsuchiya, Sew Peak-Chew, Clare Newell, Sheritta Miller-Aidoo, Sriyash Mangal, Alexander Zhyvoloup, Jovana Baković, Oksana Malanchuk, Gonçalo Pereira, Vassilios Kotiadis, Gyorgy Szabadkai, Michael Duchen, Mark Campbell, Sergio Rodriguez Cuenca, Antonio Vidal-Puig, Andrew James, Michael P Murphy, Valeriy Filonenko, Mark Skehel, Ivan Gout
Coenzyme A (CoA) is an obligatory cofactor in all branches of life. CoA and its derivatives are involved in major metabolic pathways, allosteric interactions and the regulation of gene expression. Abnormal biosynthesis and homeostasis of CoA and its derivatives have been associated with various human pathologies, including cancer, diabetes and neurodegeneration. Using an anti-CoA monoclonal antibody and mass spectrometry we identified a wide range of cellular proteins which are modified by covalent attachment of CoA to cysteine thiols (CoAlation)...
March 24, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28341038/acute-gout-following-dermofasciectomy-in-a-patient-with-dupuytren-disease
#3
Elliott Cochrane, Rosalyn Harper
A 62-year-old man underwent uncomplicated dermofasciectomy of the right little finger. In the week after surgery, he presented with erythema, tenderness, reduced range of movement, and a chalklike discharge from the suture line. Investigations revealed a raised serum urate level accompanied with a borderline rise in inflammatory markers. A diagnosis of acute gout was made. The patient was managed with nonsteroidal anti-inflammatory drugs. Clinicians should consider the diagnosis of gout when patients present after surgery with redness, pain, and swelling and also consider measuring urate levels before surgery and initiating colchicine prophylaxis when there is a known diagnosis of gout before surgery...
January 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28340785/an-automatic-chemiluminescence-method-based-on-the-multi-pumping-flow-system-coupled-with-the-fluidized-reactor-and-direct-injection-detector-determination-of-uric-acid-in-saliva-samples
#4
Christina Vakh, Stanislawa Koronkiewicz, Slawomir Kalinowski, Leonid Moskvin, Andrey Bulatov
A novel approach for the automatic chemiluminescence (CL) analysis of the complex samples is proposed. A multi-pumping flow system was successfully combined with fluidized reactor and direct-injection CL detector. The possibility of the approach was demonstrated on the determination of uric acid in saliva samples. Uric acid is clinically important analyte and its determination in biological fluids is related to human organism dysfunctions, such as gout. For the first time, the fast luminol - N-bromosuccinimide (NBS) reaction in an alkaline medium was used for the CL determination of uric acid in saliva samples...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28337320/discovery-and-assessment-of-atropisomers-of-%C3%A2-lesinurad
#5
Jianfei Wang, Wenqin Zeng, Shaohua Li, Liang Shen, Zhengxian Gu, Yang Zhang, Jian Li, Shuhui Chen, Xiangbo Jia
(+)- and (-)-Lesinurad were isolated as atropisomers from racemic lesinurad for the first time. No interconversion was observed between the two atropisomers under various conditions tested. The two atropisomers showed significant differences in hURAT1 highly expressed HEK293 cell-based inhibition assays, monkey pharmacokinetic studies, and in vitro human recombinant CYP2C9 stability studies. It was speculated that (+)-lesinurad might offer a better hyperuricemia/gout therapy than (-)-lesinurad or the racemate...
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28334624/simultaneous-monitoring-of-glucose-and-uric-acid-on-a-single-test-strip-with-dual-channels
#6
Jinhong Guo, Xing Ma
The conventional test strip has usually only one electrochemical reaction channel, which requires two times figure punctures for the self-management of patients suffering from both diabetes and gout. Considering the large number of such patients and for the sake of reducing their pains, we report an enzymatic test strip which can simultaneously monitor glucose and uric acid (UA) with only one fingertip blood droplet. The proposed test strip is composed of dual channels. The glucose in blood is detected in the 1st channel above on the substrate and the UA is characterized in the 2nd channel located at the bottom of the substrate...
March 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28330676/stromal-gene-expression-is-predictive-for-metastatic-primary-prostate-cancer
#7
Fan Mo, Dong Lin, Mandeep Takhar, Varune Rohan Ramnarine, Xin Dong, Robert H Bell, Stanislav V Volik, Kendric Wang, Hui Xue, Yuwei Wang, Anne Haegert, Shawn Anderson, Sonal Brahmbhatt, Nicholas Erho, Xinya Wang, Peter W Gout, James Morris, R Jeffrey Karnes, Robert B Den, Eric A Klein, Edward M Schaeffer, Ashley Ross, Shancheng Ren, S Cenk Sahinalp, Yingrui Li, Xun Xu, Jun Wang, Jian Wang, Martin E Gleave, Elai Davicioni, Yinghao Sun, Yuzhuo Wang, Colin C Collins
BACKGROUND: Clinical grading systems using clinical features alongside nomograms lack precision in guiding treatment decisions in prostate cancer (PCa). There is a critical need for identification of biomarkers that can more accurately stratify patients with primary PCa. OBJECTIVE: To identify a robust prognostic signature to better distinguish indolent from aggressive prostate cancer (PCa). DESIGN, SETTING, AND PARTICIPANTS: To develop the signature, whole-genome and whole-transcriptome sequencing was conducted on five PCa patient-derived xenograft (PDX) models collected from independent foci of a single primary tumor and exhibiting variable metastatic phenotypes...
March 19, 2017: European Urology
https://www.readbyqxmd.com/read/28330320/xanthine-oxidase-inhibitory-and-antioxidant-potential-of-indian-muscodor-species
#8
Neha Kapoor, Sanjai Saxena
Xanthine oxidase is a key enzyme responsible for hyperuricemia, a pre-disposing factor for Gout and oxidative stress-related diseases. Only two clinically approved xanthine oxidase inhibitors Allopurinol and Febuxostat are currently used for treatment of hyperuricemia. However, owing to their side effects there is a need for new non-purine-based selective inhibitors of xanthine oxidase. In the process of exploring novel xanthine oxidase inhibitors and anti-oxidants, we screened the culture filtrate of 07 novel species of Muscodor, a sterile endophytic fungi isolated from Cinnamomum and Aegle marmelos...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329594/perforating-gout-of-the-ear
#9
Leigh Sutton, Palak Parekh
Gout is the most common cause of inflammatory arthritis in men over 40 [1]. The prevalence of gout in the US is approximately 3.9%. Tophus is a characteristic sign of gout and results when monosodium urate deposits at the joint, skin, or cartilage. Tophi develop in 12-35% of patients who are diagnosed with gout [2]. We report a case of a 70-year-old man who was diagnosed with squamous cell carcinoma of the helix via shave biopsy. During Mohs micrographic surgery, a vigorous foreign-body reaction was noted. Review of the initial biopsy slides identified crystals with pseudoepitheliomatous hyperplasia (PEH) rendering a diagnosis of gout...
October 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28327188/allopurinol-and-the-risk-of-ventricular-arrhythmias-in-the-elderly-a-study-using-us-medicare-data
#10
Jasvinder A Singh, John Cleveland
BACKGROUND: There are no published human studies investigating whether the use of allopurinol, the most commonly used medication for the treatment of hyperuricemia in gout, the most common type of inflammatory arthritis in adults, has any beneficial effects on ventricular electrophysiology. The objective of our study was to assess whether allopurinol use is associated with a reduction in the risk of ventricular arrhythmias (VA). METHODS: We used the 5% random sample of Medicare beneficiaries from 2006-2012 to examine new allopurinol use and the risk of incident VA...
March 22, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28326103/bilateral-olecranon-tophaceous-gout-bursitis
#11
Güzelali Özdemir, Alper Deveci, Kemal Andıç, Niyazi Erdem Yaşar
In this case, we present a patient with the diagnosis of bilateral olecranon tophaceous gout. After the surgical treatment, there was no limitation of range of motion or wound problem at 6th month control.
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28321655/quantum-chemical-nmr-ft-ir-and-esi-ms-studies-of-complexes-of-colchicine-with-zn-ii
#12
Wojciech Jankowski, Joanna Kurek, Piotr Barczyński, Marcin Hoffmann
Colchicine is a tropolone alkaloid from Colchicinum autumnale. It shows antifibrotic, antimitotic, and anti-inflammatory activities, and is used to treat gout and Mediterranean fever. In this work, complexes of colchicine with zinc(II) nitrate were synthesized and investigated using DFT, (1)H and (13)C NMR, FT IR, and ESI MS. The counterpoise-corrected and uncorrected interaction energies of these complexes were calculated. We also calculated their (1)H, (13)C NMR, and IR spectra and compared them with the corresponding experimentally obtained data...
April 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28314986/false-positive-synovial-fluid-alpha-defensin-test-in-a-patient-with-acute-gout-affecting-a-prosthetic-knee
#13
D G Partridge, A Gordon, R Townsend
The alpha-defensin test has demonstrated promising results in studies evaluating it for the diagnosis of prosthetic joint infection. There are limited data in the literature regarding its use in patients with other inflammatory joint conditions, but a high specificity for infection has been reported. We describe a patient with a prosthetic knee joint, who had a positive alpha-defensin lateral flow assay but in whom subsequent results confirmed a diagnosis of acute gout with no evidence of infection.
March 17, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28314755/a-randomised-controlled-trial-of-the-efficacy-and-safety-of-allopurinol-dose-escalation-to-achieve-target-serum-urate-in-people-with-gout
#14
Lisa K Stamp, Peter T Chapman, Murray L Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake, Nicola Dalbeth
OBJECTIVES: To determine the efficacy and safety of allopurinol dose escalation using a treat-to-target serum urate (SU) approach. METHODS: A randomised, controlled, parallel-group, comparative clinical trial was undertaken. People with gout receiving at least creatinine clearance (CrCL)-based allopurinol dose for ≥1 month and SU ≥6 mg/dL were recruited. Participants were randomised to continue current dose (control) or allopurinol dose escalation for 12 months...
March 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28304005/cubital-tunnel-syndrome-secondary-to-gouty-tophi-a-case-report
#15
Hatice Resorlu, Coskun Zateri, Ayla Akbal, Ferhat Gokmen, Gurhan Adam, Serhad Bilim, Emre Bozkurt
Gout is a chronic rheumatic disease resulting from accumulation of monosodium urate crystals in tissues. The most important risk factor for the disease is hyperuricaemia. Precipitation of uric acid in the joint in the form of monosodium urate crystals is the main factor responsible for triggering attacks of arthritis. Tophi occur as a result of urate crystals that precipitate into joints and surrounding tissues. Tophi can erode the bone where they are located and cause compression in soft tissue due to a mass effect...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28303668/beliefs-about-medicines-among-older-hospital-outpatients-in-hong-kong
#16
Bosco K F Wan, Walter H K Cheung, Patrick A Ball, David M Jackson, Gregg J Maynard
OBJECTIVES: (1) To identify demographic characteristics associated with different patients' belief attitudes and assess any correlation between medication beliefs and adherence among older Hong Kong hospital outpatients. (2) To identify important implementation criteria for developing a more effective adherence-improving intervention. METHODS: Six hundred and ninety-eight patients completed a questionnaire consisting of demographic information, Morisky Medications Adherence Scale-8 (MMAS-8) and Belief about Medicines Questionnaire...
March 16, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28302506/xanthine-oxidase-inhibitory-activity-of-nicotino-isonicotinohydrazides-a-systematic-approach-from-in-vitro-in-silico-to-in-vivo-studies
#17
Humaira Zafar, Muhammad Hayat, Sumayya Saied, Momin Khan, Uzma Salar, Rizwana Malik, M Iqbal Choudhary, Khalid Mohammed Khan
Change in life style and eating habits has led to an increased prevalence of hyperuricemia worldwide. The role of hyperuricemia is no more restricted to gout, but it has a central role in progression of CVD, hypertension, metabolic syndrome, and arthritis. Among the different factors involved in regulation of serum uric acid, xanthine oxidase (XO) is the best pharmacological target to control the levels of serum uric acid as it catalyzes the final steps in uric acid production. In the current study, a systemic search for the inhibitors of xanthine oxidase, starting from synthesis to in vitro screening and leading to in vivo studies is presented...
February 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28302027/in-silico-design-and-admet-studies-of-natural-compounds-as-inhibitors-of-xanthine-oxidase-xo-enzyme
#18
Neelam Malik, Priyanka Dhiman, Anurag Khatkar
BACKGROUND: Xanthine oxidase a ubiquitous enzyme has been found to be involved in various pathological disorders including gout, hyperuricemia, inflammation, oxidative stress and cardiovascular diseases. Inhibitors of xanthine oxidase thus find a crucial role in the therapeutic treatment of these deadly diseases. OBJECTIVE: Considering the side effects of today's treatment regimen here we choose nature based compounds to act as xanthine oxidase inhibitors. In the present work, we performed in-silico docking of natural compounds to reveal the underlying mechanism of inhibition of xanthine oxidase...
March 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28296744/hypouricemic-and-arthritis-relapse-reducing-effects-of-compound-tufuling-oral-liquid-in-intercritical-and-chronic-gout-a-double-blind-placebo-controlled-multicenter-randomized-trial
#19
RANDOMIZED CONTROLLED TRIAL
Zhijun Xie, Huaxiang Wu, Xiaoqing Jing, Xiuyang Li, Yasong Li, Yongmei Han, Xiangfu Gao, Xiaopo Tang, Jing Sun, Yongshen Fan, Chengping Wen
TRIAL DESIGN: In the double-blind, randomized, controlled trial, we aimed to evaluate the effects of compound tufuling oral liquid (CoTOL) on serum uric acid (sUA) levels and recurrence of acute gouty arthritis in intercritical and chronic gout treatment. METHODS: A total of 210 patients with gout were screened from 8 hospitals to observe the sUA and acute gouty arthritis recurrence rate-reducing effects of CoTOL in intercritical and chronic gout during a 12-week treatment...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28294565/ankle-pathologies-in-patients-with-inflammatory-rheumatic-diseases-a-clinical-and-ultrasonographic-study
#20
Halil Harman, İbrahim Tekeoğlu
AIM: We determined ankle pathologies in patients with different types of inflammatory rheumatic diseases using high-resolution ultrasonographic (US) images, and compared the findings among the different patient groups. METHODS: The study included 142 randomly selected inflammatory rheumatic disease patients with clinically swollen or painful ankle joints; 69 patients had rheumatoid arthritis (RA), 58 had spondyloarthropathies (SpA) and 15 had gout. Ankle assessment on US included all of the important anatomical structures...
March 12, 2017: International Journal of Rheumatic Diseases
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