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https://www.readbyqxmd.com/read/30231244/analysis-of-oral-microbiota-revealed-high-abundance-of-prevotella-intermedia-in-gout-patients
#1
Juan Liu, Li Cui, Xinmin Yan, Xinyuan Zhao, Jinluo Cheng, Lei Zhou, Jianbo Gao, Zhong Cao, Xinhua Ye, Shen Hu
BACKGROUND/AIMS: Microbes reside in a number of body sites, including the oral cavity, and are associated with the progression of many systemic diseases. In this study, we aimed to investigate the effects of gout and hyperuricemia (HUA) on the composition of oral microbiomes. METHODS: Analysis of the oral microbiota from 12 gout patients, 11 HUA patients, and 19 healthy control subjects was performed using a deep sequencing approach, and validation of significant changes in Prevotella intermedia and Serratia marcescens in new patient cohorts was performed using quantitative PCR (qPCR)...
September 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30228306/15d-pgj-2-loaded-nanocapsules-ameliorate-experimental-gout-arthritis-by-reducing-pain-and-inflammation-in-a-ppar-gamma-sensitive-manner-in-mice
#2
Kenji W Ruiz-Miyazawa, Larissa Staurengo-Ferrari, Felipe A Pinho-Ribeiro, Victor Fattori, Tiago H Zaninelli, Stephanie Badaro-Garcia, Sergio M Borghi, Ketlem C Andrade, Juliana T Clemente-Napimoga, Jose C Alves-Filho, Thiago M Cunha, Leonardo F Fraceto, Fernando Q Cunha, Marcelo H Napimoga, Rubia Casagrande, Waldiceu A Verri
Gout arthritis (GA) is a painful inflammatory disease in response to monosodium urate (MSU) crystals in the joints. 15deoxy-Δ12,14 -prostaglandin J2 (15d-PGJ2 ) is a natural activator of PPAR-γ with analgesic, anti-inflammatory, and pro-resolution properties. Thus, we aimed to evaluate the effect and mechanisms of action of 15d-PGJ2 nanocapsules (NC) in the model of GA in mice, since a reduction of 33-fold in the dose of 15d-PGJ2 has been reported. Mice were treated with 15d-PGJ2 -loaded NC, inert NC, free 15d-PGJ2 (without NC), or 15d-PGJ2 -loaded NC+ GW9662, a PPAR-γ inhibitor...
September 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30225600/combining-non-contrast-and-dual-energy-ct-improves-diagnosis-of-early-gout
#3
Seul Ki Lee, Joon-Yong Jung, Won-Hee Jee, Jennifer Jooha Lee, Sung-Hwan Park
OBJECTIVES: To determine the incremental value of non-contrast CT (NCCT) on dual-energy CT (DECT) in symptomatic first metatarsophalangeal (MTP) joints in early gout. METHODS: One hundred and fifteen painful joints were consecutively enrolled and gout was diagnosed based on the 2015 EULAR/ACR criteria and/or arthrocentesis. Two readers independently evaluated DECT alone and combined NCCT and DECT (NCCT+DECT) based on four semiquantitative scales. Sensitivities and specificities were compared using McNemar's test...
September 17, 2018: European Radiology
https://www.readbyqxmd.com/read/30223875/monosodium-urate-burden-assessed-with-dual-energy-computed-tomography-predicts-the-risk-of-flares-in-gout-a-12-month-observational-study-msu-burden-and-risk-of-gout-flare
#4
Tristan Pascart, Agathe Grandjean, Benoist Capon, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, Hélène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak, Jean-François Budzik
BACKGROUND: Predicting the risk of flares in patients with gout is a challenge and the link between urate burden and the risk of gout flare is unclear. The objective of this study was to determine if the extent of monosodium urate (MSU) burden measured with dual-energy computed tomography (DECT) and ultrasonography (US) is predictive of the risk of gout flares. METHODS: This prospective observational study recruited patients with gout to undergo MSU burden assessment with DECT (volume of deposits) and US (double contour sign) scans of the knees and feet...
September 17, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/30220609/manufacture-of-a-high-definition-ocular-prosthesis
#5
E Walshaw, T Zoltie, P Bartlett, T Gout
No abstract text is available yet for this article.
September 13, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/30219951/multicenter-open-label-study-of-long-term-topiroxostat-fyx-051-administration-in-japanese-hyperuricemic-patients-with-or-without-gout
#6
Tatsuo Hosoya, Tomohiko Ishikawa, Yoshimi Ogawa, Ryusuke Sakamoto, Tetsuo Ohashi
BACKGROUND AND OBJECTIVES: Topiroxostat-a novel selective xanthine oxidoreductase inhibitor-has been reported to reduce serum urate levels. The purpose of this study was to assess the efficacy and safety of long-term topiroxostat administration in Japanese hyperuricemic patients with or without gout. METHODS: This multicenter, open-label study evaluated the efficacy and safety of long-term twice-daily oral topiroxostat administration in patients with or  without gout...
September 15, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/30219188/the-role-of-dual-energy-computed-tomography-in-musculoskeletal-imaging
#7
REVIEW
Takeshi Fukuda, Kunihiko Fukuda
Dual-energy computed tomography (DECT) enables material decomposition and virtual monochromatic images by acquiring 2 different energy X-ray data sets. DECT can detect musculoskeletal pathologic conditions that CT alone cannot, and that would otherwise require MR imaging. In this review, the authors discuss several useful techniques and applications of DECT in musculoskeletal research: virtual monochromatic images, virtual noncalcium images, gout, iodine map, and tendons.
October 2018: PET Clinics
https://www.readbyqxmd.com/read/30214650/pulmonary-artery-pseudoaneurysms-in-the-setting-of-gout-polyarthropathy-a-case-report
#8
Amelia Bai, Ling Lan, Karl Poon, Varghese Pynadath Joseph, Rachael O'Rourke, Khurrum Aftab
Pulmonary artery pseudoaneurysm is a dangerous pathology often missed as a differential and on imaging. With a 50% mortality rate early detection and intervention are critical to patient outcome, rendering diagnosis based on clinical grounds to be of paramount importance. A high index of suspicion should be placed on patients presenting with unprovoked hemoptysis, hemorrhage or hemothorax. Knowledge of the common causes of pulmonary artery pseudoaneurysms is also important; however, it is integral to note spontaneous occurrences in patients with no known risk factors...
October 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/30213692/nutritional-recommendations-for-gout-an-update-from-clinical-epidemiology
#9
REVIEW
Sabrina Mai Nielsen, Kristian Zobbe, Lars Erik Kristensen, Robin Christensen
OBJECTIVE: To present the evidence for nutritional lifestyle changes recommended for gout patients; an explicit focus will be on the evidence for weight loss in overweight gout patients based on a recent systematic review and to describe methodological details for a coming weight loss trial. METHODS: We did a pragmatic but systematic search in MEDLINE for current guidelines that had made an attempt to make nutritional recommendations for gout. The quality of the evidence for the nutritional recommendations was evaluated based on the guidelines' own ratings and converted into a common simple version based on the GRADE system...
September 10, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/30211208/chronic-carpal-tunnel-syndrome-caused-by-covert-tophaceous-gout-a-case-report
#10
Peng-Bo Luo, Chang-Qing Zhang
Carpal tunnel syndrome (CTS) is well recognized as the most common type of peripheral neuropathy. A rare cause of CTS is tophaceous gout. Tophi deposits can accumulate in various structures including the flexor tendons, tendon sheaths, the carpal tunnel floor, transverse carpal ligament, and even the median nerve, causing various symptoms such as pain, numbness, and weakness. Tophi forming in the carpal canal can compress the median nerve, leading to CTS. Here, we describe a 25-year-old male with a family history of tophaceous gout who presented with typical CTS symptoms...
September 6, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/30203749/the-efficacy-of-febuxostat-and-allopurinol-in-the-treatment-of-gout-with-hyperuricemia
#11
Sufang Wang
The aim of this research work was to observe and analyze the efficacy of febuxostat and allopurinol in the treatment of gout with hyperuricemia. The 160 patients who has been diagnosed with gout and hyperuricemia in our hospital were selected as research objects. They were randomly divided into research group and control group, each containing 80. The control group received conventional allopurinol treatment, while the research group was treated with febuxostat. Then, the treatment efficacy was compared between the two groups...
July 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30202096/urate-transporter-inhibitor-lesinurad-is-a-selective-peroxisome-proliferator-activated-receptor-gamma-modulator-sppar%C3%AE-m-in-vitro
#12
Pascal Heitel, Leonie Gellrich, Jan Heering, Tamara Goebel, Astrid Kahnt, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk
Gout is the most common arthritic disease in human but was long neglected and therapeutic options are not satisfying. However, with the recent approval of the urate transporter inhibitor lesinurad, gout treatment has experienced a major innovation. Here we show that lesinurad possesses considerable modulatory potency on peroxisome proliferator-activated receptor γ (PPARγ). Since gout has a strong association with metabolic diseases such as type 2 diabetes, this side-activity appears as very valuable contributing factor to the clinical efficacy profile of lesinurad...
September 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30201038/monosodium-urate-crystals-reduce-osteocyte-viability-and-indirectly-promote-a-shift-in-osteocyte-function-towards-a-proinflammatory-and-proresorptive-state
#13
Ashika Chhana, Bregina Pool, Karen E Callon, Mei Lin Tay, David Musson, Dorit Naot, Geraldine McCarthy, Susan McGlashan, Jillian Cornish, Nicola Dalbeth
BACKGROUND: Bone erosion is a frequent complication of gout and is strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are important cellular mediators of bone remodeling. The aim of this study was to investigate the direct effects of MSU crystals and indirect effects of MSU crystal-induced inflammation on osteocytes. METHODS: For direct assays, MSU crystals were added to MLO-Y4 osteocyte cell line cultures or primary mouse osteocyte cultures...
September 10, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/30201030/correction-to-comorbidity-in-gout-at-the-time-of-first-diagnosis-sex-differences-that-may-have-implications-for-dosing-of-urate-lowering-therapy
#14
Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd, Lennart T H Jacobsson, Mats Dehlin
Unfortunately, after publication of this article [1], it was noticed that Fig. 2 is incorrect.
September 10, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/30200166/risk-of-diabetes-mellitus-in-hiv-infected-patients-receiving-highly-active-antiretroviral-therapy-a-nationwide-population-based-study
#15
Shih Ping Lin, Chun-Ying Wu, Chang-Bi Wang, Tsai-Chung Li, Nai-Ying Ko, Zhi-Yuan Shi
Previous studies have shown that the incidence of diabetes mellitus (DM) has increased in human immunodeficiency virus (HIV)-infected patients with long-term exposure to highly active antiretroviral therapy (HAART). However, the factors associated with DM among HIV-infected patients in Asia remain unclear in the HAART era.A nationwide cohort studyData from Taiwan's National Health Insurance Research Database (NHIRD) between 2000 and 2010 were used to investigate the incidence of and factors associated with DM among HIV-infected patients...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30196323/febuxostat-in-the-treatment-of-gout-patients-with-low-serum-uric-acid-level-1-year-finding-of-efficacy-and-safety-study
#16
Minning Shen, Junyu Zhang, Kai Qian, Chunmei Li, Wenyu Xu, Bingjie Gu, Xiaoqin Wang, Qijie Ren, Leilei Yang, Hai Yuan, Dinglei Su, Xingguo Chen
To retrospectively analyze the efficacy and safety of febuxostat on gout patients with low serum uric acid level. A study was conducted in Nanjing First Hospital from October 2015 to September 2016. Thirty nine acute gouty arthritis patients from the emergency and outpatient department were included. Patients met the 2015 Gout Classification Criteria revised by American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) and had urate deposition around the joints detected by dual-energy computerized tomography (DECT)...
September 9, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30194450/vegf-165-b-a-splice-variant-of-vegf-a-promotes-lung-tumor-progression-and-escape-from-anti-angiogenic-therapies-through-a-%C3%AE-1-integrin-vegfr-autocrine-loop
#17
Asma Boudria, Cherine Abou Faycal, Tao Jia, Stephanie Gout, Michelle Keramidas, Chloé Didier, Nicolas Lemaître, Sandra Manet, Jean-Luc Coll, Anne-Claire Toffart, Denis Moro-Sibilot, Corinne Albiges-Rizo, Véronique Josserand, Eva Faurobert, Christian Brambilla, Elisabeth Brambilla, Sylvie Gazzeri, Beatrice Eymin
Vascular endothelial growth factor-A (VEGF-A) is highly subjected to alternative pre-mRNA splicing that generates several splice variants. The VEGFxxx and VEGFxxx b families encode splice variants of VEGF-A that differ only at the level of six amino acids in their C-terminal part. The expression level of VEGFxxx splice variants and their function as pro-angiogenic factors during tumor neo-angiogenesis have been well-described. The role of VEGFxxx b isoforms is less well known, but they have been shown to inhibit VEGFxxx -mediated angiogenesis, while being partial or weak activators of VEGFR receptors in endothelial cells...
September 7, 2018: Oncogene
https://www.readbyqxmd.com/read/30192150/intramolecular-diels-alder-reaction-of-a-silyl-substituted-vinylimidazole-en-route-to-the-fully-substituted-cyclopentane-core-of-oroidin-dimers
#18
Abhisek Ray, Muhammed Yousufuddin, Delphine Gout, Carl J Lovely
An intramolecular Diels-Alder reaction of a silyl-substituted vinylimidazole delivers a diastereomeric mixture of C4-silyl functionalized dihydrobenzimidazoles. Subsequent diastereoselective reduction and elaboration of the lactone gives rise to a polysubstituted tetrahydrobenzimidazole, which, upon oxidative rearrangement, affords a single spirofused imidazolone containing all of the relevant functionality for an approach to the oroidin dimers axinellamine, massadine, and palau'amine.
September 7, 2018: Organic Letters
https://www.readbyqxmd.com/read/30190520/calcium-crystal-deposition-diseases-beyond-gout
#19
REVIEW
Geraldine M McCarthy, Aisling Dunne
The most common types of calcium-containing crystals that are associated with joint and periarticular disorders are calcium pyrophosphate dihydrate (CPP) and basic calcium phosphate (BCP) crystals. Several diverse but difficult-to-treat acute and chronic arthropathies and other clinical syndromes are associated with the deposition of these crystals. Although the pathogenic mechanism of calcium crystal deposition is partially understood, much remains to be investigated, as no drug is available to prevent crystal deposition, permit crystal dissolution or specifically target the pathogenic effects that result in the clinical manifestations...
September 6, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30189890/arhalofenate-acid-inhibits-monosodium-urate-crystal-induced-inflammatory-responses-through-activation-of-amp-activated-protein-kinase-ampk-signaling
#20
Charles McWherter, Yun-Jung Choi, Ramon L Serrano, Sushil K Mahata, Robert Terkeltaub, Ru Liu-Bryan
BACKGROUND: Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arthritis flares in arhalofenate-treated gout compared with allopurinol alone. Hence, we investigated the anti-inflammatory effects and mechanisms of arhalofenate and its active acid form for responses to monosodium urate (MSU) crystals. METHODS: We assessed in-vivo responses to MSU crystals in murine subcutaneous air pouches and in-vitro responses in murine bone marrow-derived macrophages (BMDMs) by enzyme-linked immunosorbent assay (ELISA), SDS-PAGE/Western blot, immunostaining, and transmission electron microscopy analyses...
September 6, 2018: Arthritis Research & Therapy
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