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https://www.readbyqxmd.com/read/28229032/role-of-dual-energy-computed-tomography-imaging-in-the-diagnosis-of-gout
#1
REVIEW
Divya Jayakumar, Shiv T Sehra, Suneesh Anand, Gary W Stallings, Abhijeet Danve
Gout is a well-known inflammatory arthritis and affects four percent of the United States population. It results from the deposition of uric acid crystals in joints, tendons, bursae, and other surrounding tissues. Prevalence of gout has increased in the recent decade. Gout is usually seen in conjunction with other chronic comorbid conditions like cardiac disease, metabolic syndrome, and renal disease. The diagnosis of this inflammatory arthritis is confirmed by visualization of monosodium urate (MSU) crystals in the synovial fluid...
January 20, 2017: Curēus
https://www.readbyqxmd.com/read/28225966/chronic-tophaceous-gout-in-patients-with-psoriasis
#2
Laís Cruz Lobato, Jéssica Castiel Coutinho, Maria Zeli Moreira Frota, Antonio Pedro Mendes Schettini, Mônica Santos
Psoriasis is a chronic inflammatory disease of multifactorial etiology influenced by genetic, immunological, and environmental factors. We report the case of a patient with psoriasis for more than 25 years who developed hyperuricemia and chronic tophaceous gout with unusual appearance. In psoriasis, hyperuricemia may occur by increased epidermal cell turnover, which accelerates purine metabolism and has uric acid as the product of its catabolism. The association of psoriasis with hyperuricemia can trigger the onset of gouty arthritis, and pose a greater risk of developing other inflammatory comorbidities...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28223842/development-of-a-novel-algorithm-to-determine-adherence-to-chronic-pain-treatment-guidelines-using-administrative-claims
#3
Jay M Margolis, Nicole Princic, David M Smith, Lucy Abraham, Joseph C Cappelleri, Sonali N Shah, Peter W Park
OBJECTIVE: To develop a claims-based algorithm for identifying patients who are adherent versus nonadherent to published guidelines for chronic pain management. METHODS: Using medical and pharmacy health care claims from the MarketScan® Commercial and Medicare Supplemental Databases, patients were selected during July 1, 2010, to June 30, 2012, with the following chronic pain conditions: osteoarthritis (OA), gout (GT), painful diabetic peripheral neuropathy (pDPN), post-herpetic neuralgia (PHN), and fibromyalgia (FM)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28223818/an-evidence-based-review-on-urate-lowering-treatments-implications-for-optimal-treatment-of-chronic-hyperuricemia
#4
REVIEW
Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi
Several studies suggest that chronic hyperuricemia, the main precursor of gout, is involved in the pathogenesis of different systemic disorders that affect cardiovascular and renal systems, such as hypertension, obesity, hypercholesterolemia, atherosclerosis, metabolic syndrome, chronic heart failure, and chronic kidney disease. Recent epidemiological evidence has shown an increasing trend in the prevalence of hyperuricemia and gout in the Western world: a number of population-based studies estimate a prevalence of up to 21% for hyperuricemia and 1%-4% for gout...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28219882/incident-myocardial-infarction-associated-with-major-types-of-arthritis-in-the-general-population-a-systematic-review-and-meta-analysis
#5
Orit Schieir, Cedomir Tosevski, Richard H Glazier, Sheilah Hogg-Johnson, Elizabeth M Badley
OBJECTIVE: To synthesise, quantify and compare risks for incident myocardial infarction (MI) across five major types of arthritis in population-based studies. METHODS: A systematic search was performed in MEDLINE, EMBASE and CINAHL databases with additional manual/hand searches for population-based cohort or case-control studies published in English of French between January 1980 and January 2015 with a measure of effect and variance for associations between incident MI and five major types of arthritis: rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), gout or osteoarthritis (OA), adjusted for at least age and sex...
February 20, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28217895/serum-urate-levels-predict-joint-space-narrowing-in-non-gout-patients-with-medial-knee-osteoarthritis
#6
Svetlana Krasnokutsky, Charles Oshinsky, Mukundan Attur, Sisi Ma, Hua Zhou, Fangfei Zheng, Meng Chen, Jyoti Patel, Jonathan Samuels, Virginia C Pike, Ravinder Regatte, Jenny Bencardino, Leon Rybak, Steven Abramson, Michael H Pillinger
OBJECTIVE: OA pathogenesis includes both mechanical and inflammatory features. Studies have implicated synovial fluid urate (UA) as a potential OA biomarker, possibly reflecting chondrocyte damage. Whether serum urate (sUA) levels reflect/contribute to OA is unknown. We investigated whether sUA predicts OA progression in a non-gout knee OA population. METHODS: Eighty-eight subjects with medial knee OA (BMI <33) but without gout were included. Baseline sUA was measured in previously banked serum...
February 19, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28209629/burden-of-musculoskeletal-disorders-in-the-eastern-mediterranean-region-1990-2013-findings-from-the-global-burden-of-disease-study-2013
#7
Maziar Moradi-Lakeh, Mohammad H Forouzanfar, Stein Emil Vollset, Charbel El Bcheraoui, Farah Daoud, Ashkan Afshin, Raghid Charara, Ibrahim Khalil, Hideki Higashi, Mohamed Magdy Abd El Razek, Aliasghar Ahmad Kiadaliri, Khurshid Alam, Nadia Akseer, Nawal Al-Hamad, Raghib Ali, Mohammad AbdulAziz AlMazroa, Mahmoud A Alomari, Abdullah A Al-Rabeeah, Ubai Alsharif, Khalid A Altirkawi, Suleman Atique, Alaa Badawi, Lope H Barrero, Mohammed Basulaiman, Shahrzad Bazargan-Hejazi, Neeraj Bedi, Isabela M Bensenor, Rachelle Buchbinder, Hadi Danawi, Samath D Dharmaratne, Faiez Zannad, Maryam S Farvid, Seyed-Mohammad Fereshtehnejad, Farshad Farzadfar, Florian Fischer, Rahul Gupta, Randah Ribhi Hamadeh, Samer Hamidi, Masako Horino, Damian G Hoy, Mohamed Hsairi, Abdullatif Husseini, Mehdi Javanbakht, Jost B Jonas, Amir Kasaeian, Ejaz Ahmad Khan, Jagdish Khubchandani, Ann Kristin Knudsen, Jacek A Kopec, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Azeem Majeed, Reza Malekzadeh, Kedar Mate, Alem Mehari, Michele Meltzer, Ziad A Memish, Mojde Mirarefin, Shafiu Mohammed, Aliya Naheed, Carla Makhlouf Obermeyer, In-Hwan Oh, Eun-Kee Park, Emmanuel Kwame Peprah, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Vafa Rahimi-Movaghar, Rahman Shiri, Sajjad Ur Rahman, Rajesh Kumar Rai, Saleem M Rana, Sadaf G Sepanlou, Masood Ali Shaikh, Ivy Shiue, Abla Mehio Sibai, Diego Augusto Santos Silva, Jasvinder A Singh, Jens Christoffer Skogen, Abdullah Sulieman Terkawi, Kingsley N Ukwaja, Ronny Westerman, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Zoubida Zaidi, Maysaa El Sayed Zaki, Stephen S Lim, Haidong Wang, Theo Vos, Mohsen Naghavi, Alan D Lopez, Christopher J L Murray, Ali H Mokdad
OBJECTIVES: We used findings from the Global Burden of Disease Study 2013 to report the burden of musculoskeletal disorders in the Eastern Mediterranean Region (EMR). METHODS: The burden of musculoskeletal disorders was calculated for the EMR's 22 countries between 1990 and 2013. A systematic analysis was performed on mortality and morbidity data to estimate prevalence, death, years of live lost, years lived with disability and disability-adjusted life years (DALYs)...
February 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28209572/gout-medication-and-cardiovascular-risk-and-other-stories
#8
(no author information available yet)
No abstract text is available yet for this article.
February 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28208882/pbl-trigger-design-by-medical-students-an-effective-active-learning-strategy-outside-the-classroom
#9
Maya Roche, Indira Kakkunje Adiga, Akshatha G Nayak
INTRODUCTION: Problem Based Learning (PBL) is known world over as an effective, active learning strategy with many benefits for the student. Usually, in medical schools, PBL triggers are designed by a well-trained group of faculty from basic and clinical sciences. The challenge was whether this task could be given to students in the first year of their curriculum and be executed by them effectively. AIM: To enhance active learning, comprehension and critical thinking with a view to promote horizontal and vertical integration between subjects...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208602/a-review-of-the-strain-diversity-and-pathogenesis-of-chicken-astrovirus
#10
REVIEW
Victoria J Smyth
Although a relatively recently emerged virus, identified only in 2004 as a separate species of avian astrovirus, chicken astrovirus (CAstV) has been associated with poor growth of broiler flocks, enteritis and diarrhea and is a candidate pathogen in cases of runting stunting syndrome. More recently CAstV has been implicated in cases of two other diseases of broilers as the sole etiological agent, namely severe kidney disease of young broilers with visceral gout and the "White Chicks" hatchery disease. Examination of the strains of CAstV associated with the two latter diseases reveals they are closely related genetically...
February 10, 2017: Viruses
https://www.readbyqxmd.com/read/28205336/achieving-serum-urate-targets-in-gout-an-audit-in-a-gout-oriented-rheumatology-practice
#11
Elizabeth J M Corbett, Peta Pentony, Neil W McGill
AIM: To assess the proportion of patients with gout who achieve target serum urate levels, the drug regime required and the reasons for failing to do so. METHODS: We reviewed the files of all patients with gout who presented to a gout-oriented rheumatology practice between January 2010 and September 2014. RESULTS: Two hundred and thirty patients agreed to commence urate lowering therapy (ULT); 73% achieved their urate target, including 74% with non-tophaceous gout (target ≤ 0...
February 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28202946/association-of-serum-uric-acid-with-subsequent-arterial-stiffness-and-renal-function-in-normotensive-subjects
#12
Shiori Nagano, Maasa Takahashi, Nobuyuki Miyai, Mayumi Oka, Miyoko Utsumi, Mitsuru Shiba, Kanae Mure, Tatsuya Takeshita, Mikio Arita
Serum uric acid (SUA) is correlated with an increased risk of not only gout but also cardiovascular diseases. The present study aimed to longitudinally evaluate the effects of SUA level on renal function and arterial stiffness in a population-based sample of normotensive subjects. The subjects completed a health checkup in 2002 at baseline and in 2011 or 2012 at the end of the follow-up period. A total of 407 normotensive subjects (171 men and 236 women) aged 26-66 years were enrolled in this study. We measured blood pressure (BP), brachial-ankle pulse wave velocity (baPWV), central BP, intima-media thickness, SUA level and estimated glomerular filtration rate (eGFR)...
February 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28202399/the-epidemiology-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-the-uk
#13
Noel Frey, Janine Jossi, Michael Bodmer, Andreas Bircher, Susan S Jick, Christoph R Meier, Julia Spoendlin
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening mucocutaneous diseases. SJS/TEN mostly manifest as a reaction to new drug use, but little is known about their incidence and epidemiology. We conducted a large observational study on the epidemiology of SJS/TEN using data from the UK-based Clinical Practice Research Datalink. Among 551 validated SJS/TEN cases, we calculated an incidence rate of 5.76 SJS/TEN cases/million person-years between 1995 and 2013, which was consistent throughout the study period, and was highest in patients aged 1-10 years and ≥80 years...
February 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28202260/allopurinol-benzbromarone-and-risk-of-coronary-heart-disease-in-gout-patients-a-population-based-study
#14
Hsiu-Chen Lin, Masao Daimon, Ching-Hung Wang, Yi Ho, Yow-Shieng Uang, Shuo-Ju Chiang, Li-Hsuan Wang
BACKGROUND: The effect of gout on the risk of developing coronary artery disease (CAD) is uncertain. Some studies have found that gout is a risk factor for acute myocardial infarction. This study examined the changes in risk of CAD in gout patients taking allopurinol and/or benzbromarone, and analyzed the dose-response relationship of both drugs with CAD incidence. METHODS: The medical records of one million subjects from 2000 to 2011 were provided by the Taiwan National Health Insurance Research Database...
February 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28186844/prevalence-of-calcified-carotid-artery-atheromas-on-panoramic-images-of-older-men-with-gout-a-descriptive-retrospective-study
#15
Arthur H Friedlander, Lindsay L Graves, Shannon C Grabich, Nona Aghazadeh-Sanai, Tina I Chang
OBJECTIVES: Given the enhanced risk of ischemic stroke resulting from the direct effects of hyperuricemia on vascular plaque formation seen among older males with gout we sought to determine the prevalence of calcified carotid artery atheromas (CCAA) on their panoramic images. METHODS: Medical records librarians identified all male patients over age 45 who had a diagnosis of gout and a panoramic image incidentally obtained between 2000-2015. The prevalence rate of CCAA on technically appropriate images was determined as were these patients' atherogenic risk profiles including: age, BMI, hypertension, dyslipidemia...
February 10, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28178762/pet-trumps-surgical-staging-in-locally-advanced-cervical-cancer
#16
Leigh A Cantrell, Linda R Duska
Locally advanced cervical cancer (LACC) is a significant problem. The status of the para-aortic lymph nodes (PALN) in women with LACC is critical, as positive PALN dictate extended radiation fields and portend a dismal prognosis. Since 10-25% of women with LACC will have PALN metastases (S Gout, et al. Lancet Oncol 13(5) 2012), the ideal method to identify and treat them is paramount. This article is protected by copyright. All rights reserved.
February 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28164057/tubercular-tenosynovitis-of-hand-a-rare-presentation
#17
Aditya Jain, Rajesh Rohilla, Ashish Devgan, Jitendra Wadhwani
INTRODUCTION: Tuberculosis tenosynovitis of the wrist and hand is an unusual condition. It mimics a number of other clinical conditions such as ganglion, De quervan's disease, carpal tunnel syndrome, granulomatous gout, neurofibroma, and haemangioma. CASE REPORT: We present case of 58-year-old male patient with swelling over thenar region of left hand where the initial fine needle aspiration cytology (FNAC) report suggested diagnosis of ganglion/synovial cyst, but the patient did not improve with conservative treatment...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28163851/a-systematic-review-of-the-relationship-between-dystemprament-sue-mizaj-and-treatments-and-management-of-diseases-ilaj-and-eslah-e-mizaj
#18
REVIEW
Sepide Miraj, Samira Alesaeidi, Sara Kiani
BACKGROUND: Temperament refers to four different humors differentiating in individuals and, as a result, proposes specific therapy for diseases as well as special types of management (avoidance). OBJECTIVE: The aim of this study was to overview the relationship between dystemprament and treatment and management of diseases. METHODS: A computerized search of published articles was performed using PubMed, Scopus, Web of Science, and Medline databases as well as local sources from 1965 to 2016...
December 2016: Electronic Physician
https://www.readbyqxmd.com/read/28163535/lesinurad-a-significant-advancement-or-just-another-addition-to-existing-therapies-of-gout
#19
REVIEW
Ajay Gupta, Pramod Kumar Sharma, Arup Kumar Misra, Surjit Singh
Gout is a metabolic disorder that usually presents as recurrent episodes of acute arthritis due to deposition of crystals in joints and cartilages. Despite the availability of several drugs for gout, its management is still less than adequate. There is always a search for newer, safer, and more potent urate-lowering therapies for treating patients inadequately controlled with available drugs. Lesinurad in combination with a xanthine oxidase inhibitor provides an effective mode of therapy in the management of hyperuricemia associated with gout...
October 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28160246/hypogonadotropic-hypogonadism-in-males-with-glycogen-storage-disease-type-1
#20
Evelyn M Wong, Anna Lehman, Philip Acott, Jane Gillis, Daniel L Metzger, Sandra Sirrs
BACKGROUND: Glycogen storage disease type 1 is an autosomal recessive disorder with an incidence of 1 in 100,000. Long-term complications include chronic blood glucose lability, lactic academia, short stature, osteoporosis, delayed puberty, gout, progressive renal insufficiency, systemic or pulmonary hypertension, hepatic adenomas at risk for malignant transformation, anemia, vitamin D deficiency, hyperuricemic nephrocalcinosis, inflammatory bowel syndrome (type 1b), hypertriglyceridemia, and irregular menstrual cycles...
February 4, 2017: JIMD Reports
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