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https://www.readbyqxmd.com/read/29169231/evaluating-imaging-pathology-concordance-and-discordance-after-ultrasound-guided-breast-biopsy
#1
Vivian Youngjean Park, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Min Jung Kim
Ultrasound (US)-guided breast biopsy has become the main method for diagnosing breast pathology, and it has a high diagnostic accuracy, approaching that of open surgical biopsy. However, methods for confirming adequate lesion retrieval after US-guided biopsy are relatively limited and false-negative results are unavoidable. Determining imaging-pathology concordance after US-guided biopsy is essential for validating the biopsy result and providing appropriate management. In this review article, we briefly present the results of US-guided breast biopsy; describe general aspects to consider when establishing imaging-pathology concordance; and review the various categories of imaging-pathology correlations and corresponding management strategies...
August 19, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29168922/focused-ultrasound-tumor-ablation-and-its-potential-to-enhance-immunological-therapy-to-cancer
#2
Giovanni Mauri, Luca Nicosia, Zhen Xu, Salvatore Di Pietro, Lorenzo Monfardini, Guido Bonomo, Gianluca Maria Varano, Francesco Prada, Paolo Della Vigna, Franco Orsi
Various kind of image-guided techniques have been successfully applied in the last years for the treatment of tumours, as alternative to surgical resection. High Intensity focused ultrasound (HIFU) is a novel, totally non-invasive, image-guided technique that allow for achieving tissue destruction with the application of focused ultrasound at high intensity. This technique has been successfully applied for the treatment of a large variety of diseases, including oncological and non-oncological diseases. One of the most fascinating aspects of image-guided ablations, and particularly of HIFU, is the reported possibility of determining a sort of stimulation of the immune system, with an unexpected "systemic" response to treatments designed to be "local"...
November 23, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29168884/transformation-of-a-geriatric-department-in-china
#3
Birong Dong, Jirong Yue, Li Cao, Ming Yang, Ning Ge, Hao Qiukui, Lujia He, Ying Wang, Joseph H Flaherty
China has the world's largest elderly population, and the oldest-old population, with a current disability rate greater than 50%, will triple in the next 35 years. The field of geriatrics is young, because almost all geriatric departments were established after 2000, and so faces many challenges. Management of diseases and hospital care is the focus. Senior physicians were trained in other subspecialties, such as pulmonary or cardiology, and junior physicians entered geriatrics departments as masters or doctorate students after medical school...
November 23, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29168814/machinery-that-guides-immunity
#4
(no author information available yet)
No abstract text is available yet for this article.
November 23, 2017: Nature
https://www.readbyqxmd.com/read/29168763/micro-computed-tomography-guided-analysis-of-in-vitro-structural-modifications-in-two-types-of-45s5-bioactive-glass-based-scaffolds
#5
Fabian Westhauser, Francesca Ciraldo, Preethi Balasubramanian, Anne-Sophie Senger, Gerhard Schmidmaier, Arash Moghaddam, Aldo R Boccaccini
Three-dimensional 45S5 bioactive glass (BG)-based scaffolds are being investigated for bone regeneration. Besides structural properties, controlled time-dependent alteration of scaffold morphology is crucial to achieve optimal scaffold characteristics for successful bone repair. There is no in vitro evidence concerning the dependence between structural characteristics and dissolution behavior of 45S5 BG-based scaffolds of different morphology. In this study, the dissolution behavior of scaffolds fabricated by the foam replica method using polyurethane foam (Group A) and maritime sponge Spongia Agaricina (Group B) as sacrificial templates was analyzed by micro-computed-tomography (µCT)...
November 23, 2017: Materials
https://www.readbyqxmd.com/read/29168679/what-should-leaders-do-when-inefficiency-is-perceived-as-a-cost-of-inclusivity-in-strategic-planning-processes-in-health-care
#6
Aveena Kochar, Alia Chisty
During the development of new health care policies, quality improvement teams can face the challenge of weighing differing opinions within the group that can hinder progress. It is essential in such cases to refer to the four keys principles of quality improvement (QI) as a guide to enhance group cooperation and promote development of the mutual objective. Co-production is a model that emphasizes the participation of the patient-a service receiver-in the production of services being rendered by the health care professional...
November 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29168678/what-critical-ethical-values-guide-strategic-planning-processes-in-health-care-organizations
#7
Matthew Kucmanic, Amy R Sheon
This case explores a fictitious hospital's use of co-creation to make a decision about redesign of inpatient units as a first step in incorporating stakeholder input into creation of governing policies. We apply a "procedural fairness" framework to reveal that conditions required for an ethical decision about space redesign were not met by using clinician and patient focus groups to obtain stakeholder input. In this article, we identify epistemic injustices resulting from this process that could undermine confidence in leadership decisions...
November 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29168643/disruptive-therapeutic-innovation-and-the-opportunity-to-eliminate-a-chronic-disease-the-issue-of-chronic-hepatitis-c-in-spain
#8
Conrado M Fernández Rodríguez
Public funding decisions must be guided by criteria of scientific evidence, cost-effectiveness and economic evaluation. As an increase in health-effectiveness provided by therapeutic innovations can also substantially raise the cost, the cost-effectiveness analysis estimating this increase in the cost per unit of health gained compared to the previous technologies should be part of the economic evaluation. The measure of effectiveness most frequently used in health economic evaluations is the Quality Adjusted Life Year (QALY)...
November 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29168421/pet-ct-guided-interventions-indications-advantages-disadvantages-and-the-state-of-the-art
#9
Roberto Luigi Cazzato, Julien Garnon, Behnam Shaygi, Guillaume Koch, Georgia Tsoumakidou, Jean Caudrelier, Pietro Addeo, Philippe Bachellier, Izzie Jacques Namer, Afshin Gangi
Positron emission tomography/computed tomography (PET/CT) represents an emerging imaging guidance modality that has been applied to successfully guide percutaneous procedures such as biopsies and tumour ablations. The aim of the present narrative review is to report the indications, advantages and disadvantages of PET/CT-guided procedures in the field of interventional oncology and to briefly describe the experience gained with this new emerging technique while performing biopsies and tumor ablations.
November 23, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29168388/primer-in-genetics-and-genomics-article-6-basics-of-epigenetic-control
#10
Kristen L Fessele, Fay Wright
The epigenome is a collection of chemical compounds that attach to and overlay the DNA sequence to direct gene expression. Epigenetic marks do not alter DNA sequence but instead allow or silence gene activity and the subsequent production of proteins that guide the growth and development of an organism, direct and maintain cell identity, and allow for the production of primordial germ cells (PGCs; ova and spermatozoa). The three main epigenetic marks are (1) histone modification, (2) DNA methylation, and (3) noncoding RNA, and each works in a different way to regulate gene expression...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/29168322/biosynthetically-guided-structure-activity-relationship-studies-of-merochlorin%C3%A2-a-an-antibiotic-marine-natural-product
#11
Borja López-Pérez, Henry P Pepper, Rong Ma, Benjamin J Fawcett, Ashok D Pehere, Qi Wei, Zengchun Ji, Steven W Polyak, Huanqin Dai, Fuhang Song, Andrew D Abell, Lixin Zhang, Jonathan H George
The onset of new multidrug-resistant strains of bacteria demands continuous development of antibacterial agents with new chemical scaffolds and mechanisms of action. We present the first structure-activity relationship (SAR) study of 16 derivatives of a structurally novel antibiotic merochlorin A that were designed using a biosynthetic blueprint. Our lead compounds are active against several Gram-positive bacteria such as Staphylococcus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE) and Bacillus subtilis, inhibit intracellular growth of Mycobacterium bovis, and are relatively nontoxic to human cell lines...
November 23, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29168261/-impact-of-drug-reimbursement-policies-on-prescribing-a-case-study-of-a-newly-marketed-long-acting-injectable-antipsychotics-among-relapsed-schizophrenia-patients
#12
John W Jackson, Lisa Fulchino, James Rogers, Helen Mogun, Jennifer Polinski, David C Henderson, Sebastian Schneeweiss, Michael A Fischer
OBJECTIVE: To quantify and explain variation in use of long-acting injectable antipsychotics (LAIs) in the United States, and understand the relationship between patient characteristics, drug reimbursement policies, and LAI prescribing after relapse. METHODS: A cohort of recently relapsed patients with schizophrenia ages 18 to 64, identified immediately after discharge from a related inpatient hospitalization, partial hospitalization, or emergency room visit, drawn from 2004 to 2006 Medicaid claims, and followed for 90 days until LAI initiation...
November 23, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29168252/global-substrate-specificity-profiling-of-post-translational-modifying-enzymes
#13
REVIEW
Sam L Ivry, Nicole O Meyer, Michael B Winter, Markus F Bohn, Giselle M Knudsen, Anthony J O'Donoghue, Charles S Craik
Enzymes that modify the proteome, referred to as post-translational modifying (PTM) enzymes, are central regulators of cellular signaling. Determining the substrate specificity of PTM enzymes is a critical step in unraveling their biological functions both in normal physiological processes and in disease states. Advances in peptide chemistry over the last century have enabled the rapid generation of peptide libraries for querying substrate recognition by PTM enzymes. In this review, we highlight various peptide-based approaches for analysis of PTM enzyme substrate specificity...
November 23, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29168231/a-newly-hybrid-anchoring-balloon-for-direct-peroral-cholangioscopy-using-an-ultraslim-upper-endoscope
#14
Jian Li, Shao-Ju Guo, Jing-Chao Zhang, Hong-Yan Wang, Kai Li, She-Hui Niu
OBJECTIVES: Large impacted or residual invisible common bile duct (CBD) stones after mechanical lithotripsy are challenging. We aimed to evaluate the feasibility and success rate of a new hybrid anchoring balloon-guided direct peroral cholangioscopy (POC) for these conditions, using an ultraslim endoscope. METHODS: Sixty-five patients with large or residual invisible CBD stones for direct POC from July 2012 to July 2016 were identified, including 6 cases in whom an additional interventional procedure was required...
November 23, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29168230/routine-guide-wire-application-facilitates-cholangioscopy-in-the-management-of-postoperative-residual-hepatolithiasis
#15
Xu-Dong Wen, Le Xiao, Tao Wang, Nalu Navarro-Alvarez, Wei-Hui Liu
OBJECTIVES: Although postoperative cholangioscopy (POC) is considered to be an effective treatment for residual hepatolithiasis after surgery, its security and validity still needs to be improved. This study compared wire-guided POC (WG-POC) versus traditional POC (T-POC) in the management of patients with residual hepatolithiasis. METHODS: This retrospective study included a total of 203 patients who suffered from hepatolithiasis and underwent hepatectomy as initial intervention from January 1, 2016, to January 1, 2017...
November 23, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29168164/meeting-patient-expectations-patient-expectations-and-recovery-after-hip-or-knee-surgery
#16
B Wiering, D de Boer, D Delnoij
BACKGROUND: Although patient-centred care could help increase the value of healthcare, practice variations in hip and knee surgery suggest that physicians guide clinical decisions more than patients do. This raises the question whether treatment outcomes still meet patients' expectations. This study investigated whether treatment outcomes measured by patient-reported outcome measures fulfil patients' main expectations (i.e. decreased pain or improved functioning). METHODS: Patients who underwent hip or knee surgery in 20 Dutch hospitals in 2014 were invited to a survey consisting of the KOOS Physical Function Short Form or the HOOS Physical Function Short Form, the NRS pain and the EQ-5D...
November 22, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29168046/procalcitonin-guided-antibiotic-therapy-in-intensive-care-unit-patients-a-systematic-review-and-meta-analysis
#17
Hui-Bin Huang, Jin-Min Peng, Li Weng, Chun-Yao Wang, Wei Jiang, Bin Du
BACKGROUND: Serum procalcitonin (PCT) concentration is used to guide antibiotic decisions in choice, timing, and duration of anti-infection therapy to avoid antibiotic overuse. Thus, we performed a systematic review and meta-analysis to seek evidence of different PCT-guided antimicrobial strategies for critically ill patients in terms of predefined clinical outcomes. METHODS: We searched for relevant studies in PubMed, Embase, Web of Knowledge, and the Cochrane Library up to 25 February 2017...
November 22, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/29168005/a-survey-by-the-european-society-of-breast-imaging-on-the-utilisation-of-breast-mri-in-clinical-practice
#18
Paola Clauser, Ritse Mann, Alexandra Athanasiou, Helmut Prosch, Katja Pinker, Matthias Dietzel, Thomas H Helbich, Michael Fuchsjäger, Julia Camps-Herrero, Francesco Sardanelli, Gabor Forrai, Pascal A T Baltzer
OBJECTIVES: While magnetic resonance imaging (MRI) is considered a helpful diagnostic tool in breast imaging, discussions are ongoing about appropriate protocols and indications. The European Society of Breast Imaging (EUSOBI) launched a survey to evaluate the utilisation of breast MRI in clinical practice. METHODS: An online survey reviewed by the EUSOBI board and committees was distributed amongst members. The questions encompassed: training and experience; annual breast MRI and MRI-guided-intervention workload; examination protocols; indications; reporting habits and preferences...
November 22, 2017: European Radiology
https://www.readbyqxmd.com/read/29167995/ultrasound-guided-placement-of-ventricular-catheters-in-first-time-pediatric-vp-shunt-surgery
#19
Marcel Kullmann, Marina Khachatryan, Martin Ulrich Schuhmann
PURPOSE: Ventriculo-peritoneal (VP) shunts are effective for treatment of hydrocephalus in all age groups; however, they are associated with complications, a common one being ventricular catheter (VC) obstruction. VC position is likely to influence VC survival; however, most VCs are positioned freehand without guidance. This paper describes the accuracy of ultrasound guidance for VC placement and the impact of tip location on VC occlusion rate. METHODS: This is a retrospective cohort study of hydrocephalic children with first-time VP shunt and ultrasound-guided VC placement...
November 22, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29167989/tcne-modified-graphene-as-an-adsorbent-for-n2o-molecule-a-dft-study
#20
Somayeh F Rastegar, Noushin Osouleddini
Adsorption behavior of nitrous oxide (N2O) on pristine graphene (PG) and tetracyanoethylene (TCNE) modified PG surfaces is investigated using density functional theory. A number of initial adsorbate geometries are considered on both surfaces and the most stable ones are chosen upon calculation of the adsorption energies (Eads). N2O is found to adsorb in a weakly exoergic process (Eads ∼ -3.18 kJ mol(-1)) at the equilibrium distance of 3.52 Å on the PG surface. N2O adsorption can be greatly enhanced with the presence of a TCNE molecule (Eads = -87...
November 22, 2017: Journal of Molecular Modeling
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