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Normal pressure hydrocephalus

Eduardo De Pablo-Fernandez, Raph Goldacre, Julia Pakpoor, Alastair J Noyce, Thomas T Warner
OBJECTIVE: To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD). METHODS: Linked English national Hospital Episode Statistics and mortality data (1999-2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk was estimated using Cox regression models. Individuals with a coded diagnosis of cerebrovascular disease, vascular parkinsonism, drug-induced parkinsonism, and normal pressure hydrocephalus were excluded from the analysis...
June 13, 2018: Neurology
Ricardo Krause Martinez de Souza, Samanta Fabrício Blattes da Rocha, Rodrigo Tomazini Martins, Pedro André Kowacs, Ricardo Ramina
INTRODUCTION: Normal pressure hydrocephalus (NPH), described by Hakim and Adams in 1965, is characterized by gait apraxia, urinary incontinence, and dementia. It is associated with normal cerebrospinal fluid (CSF) pressure and ventricular dilation that cannot be attributed to cerebral atrophy. OBJECTIVES: To evaluate gait characteristics in patients with idiopathic NPH and investigate the effect of the CSF tap test (CSF-TT) on gait. METHODS: Twenty-five patients diagnosed with probable idiopathic NPH were submitted to the CSF-TT...
May 2018: Arquivos de Neuro-psiquiatria
Benito P Damasceno
No abstract text is available yet for this article.
May 2018: Arquivos de Neuro-psiquiatria
Wei Wang, Maode Wang, Zhijin Li, Tuo Wang, Rong Da
PURPOSE: An accurate intracranial pressure (ICP) measurement is vital for patients with hydrocephalus. ICP is generally measured by lumbar puncture opening pressure, which is invasive and has potential adverse side effects. Intraocular pressure (IOP) was investigated to measure ICP indirectly; however, its accuracy was controversial. We conducted this retrospective study to investigate whether IOP can be used as a surrogate for ICP in hydrocephalus patients. METHODS: We performed a retrospective study enrolled 50 cases, including 32 patients with normal pressure hydrocephalus (NPH) and 18 patients with high pressure hydrocephalus (HPH)...
June 8, 2018: International Journal of Neuroscience
Ryan A Townley, Hugo Botha, Jonathan Graff-Radford, Bradley F Boeve, Ronald C Petersen, Matthew L Senjem, David S Knopman, Val Lowe, Clifford R Jack, David T Jones
Background: Idiopathic normal pressure hydrocephalus (iNPH) is an important and treatable cause of neurologic impairment. Diagnosis is complicated due to symptoms overlapping with other age related disorders. The pathophysiology underlying iNPH is not well understood. We explored FDG-PET abnormalities in iNPH patients in order to determine if FDG-PET may serve as a biomarker to differentiate iNPH from common neurodegenerative disorders. Methods: We retrospectively compared 18 F-FDG PET-CT imaging patterns from seven iNPH patients (mean age 74 ± 6 years) to age and sex matched controls, as well as patients diagnosed with clinical Alzheimer's disease dementia (AD), Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD), and behavioral variant frontotemporal dementia (bvFTD)...
2018: NeuroImage: Clinical
Aakash Desai, Gaurav Manek, Anand M Krishnan, Corina Iorgoveanu, Ahmed Zaghloul
Lyme disease is a tick-borne illness caused primarily by the spirochete Borrelia burgdorferi . The disease is most prevalent in forested areas endemic for Ixodes tick, which transmits the spirochete. Here, we describe a case of Lyme meningoencephalitis masquerading as normal pressure hydrocephalus (NPH) which initially presented with urinary incontinence, gait instability, and neurological decline. Due to its non-specific symptoms and low incidence, Lyme meningoencephalitis causing NPH like syndrome poses a diagnostic conundrum for clinicians...
April 3, 2018: Curēus
Wutthiseth Dhitinanmuang, Piriyaporn Chongtrakool, Anupop Jitmuang
BACKGROUND: Cryptococcus gattii is known to be an etiologic agent of human cryptococcosis, particularly in immunocompetent persons. C. gattii infection usually involves the central nervous system, the respiratory tract, or may be disseminated. Here we report an atypical manifestation of C. gattii infection in a patient who had C. gattii meningitis complicating the ventriculoperitoneal (VP) shunt infection and concurrent infected intraabdominal VP shunt pseudocyst. CASE PRESENTATION: A 66-year-old Thai female was initially diagnosed with normal pressure hydrocephalus (NPH) and underwent programmable VP shunt placement...
June 4, 2018: BMC Infectious Diseases
Ville Leinonen, Tuomas Rauramaa, Jarkko Johansson, Astrid Bottelbergs, Ina Tesseur, Peter van der Ark, Darrel Pemberton, Anne M Koivisto, Juha E Jääskeläinen, Mikko Hiltunen, Sanna-Kaisa Herukka, Kaj Blennow, Henrik Zetterberg, Pekka Jokinen, Johanna Rokka, Semi Helin, Merja Haaparanta-Solin, Olof Solin, Nobuyuki Okamura, Hartmuth C Kolb, Juha O Rinne
BACKGROUND: Detection of pathological tau aggregates could facilitate clinical diagnosis of Alzheimer's disease (AD) and monitor drug effects in clinical trials. S-[18F]THK-5117 could be a potential tracer to detect pathological tau deposits in brain. However, no previous study have correlated S-[18F]THK-5117 uptake in PET with brain biopsy verified tau pathology in vivo. OBJECTIVE: Here we aim to evaluate the association between cerebrospinal fluid (CSF) AD biomarkers, S-[18F]THK-5117, and [11C]PIB PET against tau and amyloid lesions in brain biopsy...
May 31, 2018: Journal of Alzheimer's Disease: JAD
Aryo Zare, Ali Jahanshahi, Mohammad-Sajjad Rahnama'i, Sandra Schipper, Gommert A van Koeveringe
The periaqueductal gray matter (PAG), as one of the mostly preserved evolutionary components of the brain, is an axial structure modulating various important functions of the organism, including autonomic, behavioral, pain, and micturition control. It has a critical role in urinary bladder physiology, with respect to storage and voiding of urine. The PAG has a columnar composition and has extensive connections with its cranially and caudally located components of the central nervous system (CNS). The PAG serves as the control tower of the detrusor and sphincter contractions...
May 26, 2018: Molecular Neurobiology
Alexander Verhaeghe, Stijn De Muynck, Jan W Casselman, Nikolaas Vantomme
BACKGROUND: Pneumocephalus is usually seen in trauma or cranial surgery. It is rarely reported as a delayed complication of ventriculoperitoneal (VP) shunt placement for hydrocephalus secondary to trauma, tumor or aqueduct stenosis. In this paper, we describe a case of intraventricular pneumocephalus (NPH) presenting 10 months after placement of a shunt for normal pressure hydrocephalus. CASE DESCRIPTION: Following the diagnosis of normal pressure hydrocephalus, a pressure-regulated VP shunt was implanted in an 81-year old patient...
May 24, 2018: World Neurosurgery
Lisa Nakamura, Ryuta Saito, Masayuki Kanamori, Takahiro Morita, Ryosuke Tashiro, Teiji Tominaga
INTRODUCTION: Ventriculoperitoneal(VP)shunts function because of the pressure differential between the intracranial space and the peritoneal cavity. Although chronic constipation is often a cause of VP shunt dysfunction in children, it is not well recognized in adults. We present a case of shunt dysfunction that not only resolved after resolution of constipation but also resulted in overdrainage. CASE REPORT: A 28-year-old woman who had a VP shunt placed 11 years prior for hydrocephalus was referred to our department because of an enlarged ventricle diagnosed with computed tomography(CT)...
May 2018: No Shinkei Geka. Neurological Surgery
Francesco Belotti, Isabella Lupi, Mirco Cosottini, Claudia Ambrosi, Roberto Gasparotti, Fausto Bogazzi, Marco M Fontanella, Francesco Doglietto
Context: The persisting embryonal infundibular recess (PEIR) is a rare anomaly of the floor of the third ventricle with a debated pathogenesis. It can be a cause of misdiagnosis in case of cystic lesions of the sellar and suprasellar area. Objective: To describe two recently evaluated cases and provide a systematic literature review. Evidence acquisition and Case Descriptions: PEIR has been previously reported in 6 adult patients. As in some cases it was associated to hydrocephalus and/or empty sella, a possible role of altered intracranial pressure in PEIR formation has been postulated...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
Vikas Kotagal, Elizabeth Walkowiak, Jason A Heth
OBJECTIVE: Recent Normal Pressure Hydrocephalus (NPH) practice guidelines describe a serious adverse event (SAE) rate following surgery of 11%. PATIENTS & METHODS: We conducted a retrospective review of 162 consecutive patients who have undergone work-up at our center's multidisciplinary NPH clinic over a 47 month time period (2/2014-12/2017). Of these, 22 ultimately underwent neurosurgical ventricular shunt surgery as treatment for NPH. Clinical records were reviewed for SAEs categorized as possibly/probably/definitely related to NPH surgery...
July 2018: Clinical Neurology and Neurosurgery
Nitin Agarwal, Ahmed Kashkoush, Michael M McDowell, William R Lariviere, Naveed Ismail, Robert M Friedlander
OBJECTIVE Ventricular shunt (VS) durability has been well studied in the pediatric population and in patients with normal pressure hydrocephalus; however, further evaluation in a more heterogeneous adult population is needed. This study aims to evaluate the effect of diagnosis and valve type-fixed versus programmable-on shunt durability and cost for placement of shunts in adult patients. METHODS The authors retrospectively reviewed the medical records of all patients who underwent implantation of a VS for hydrocephalus at their institution over a 3-year period between August 2013 and October 2016 with a minimum postoperative follow-up of 6 months...
May 11, 2018: Journal of Neurosurgery
Vasco Vanhala, Antti Junkkari, Ville E Korhonen, Mitja I Kurki, Mikko Hiltunen, Tuomas Rauramaa, Ossi Nerg, Anne M Koivisto, Anne M Remes, Jonna Perälä, Jaana Suvisaari, Soili M Lehto, Heimo Viinamäki, Hilkka Soininen, Juha E Jääskeläinen, Ville Leinonen
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a progressive and potentially treatable neurodegenerative disease affecting elderly people, characterized by gait impairment and ventricular enlargement in brain imaging. Similar findings are seen in some patients with schizophrenia (SCZ). OBJECTIVE: To determine the prevalence of SCZ among patients suffering from probable or possible iNPH and the specific effects of comorbid SCZ on the outcome of the cerebrospinal fluid (CSF) shunting...
May 8, 2018: Neurosurgery
Ping-Huei Tsai, Yung-Chieh Chen, Shih-Wei Chiang, Teng-Yi Huang, Ming-Chung Chou, Hua-Shan Liu, Hsiao-Wen Chung, Giia-Sheun Peng, Hsin-I Ma, Hung-Wen Kao, Cheng-Yu Chen
OBJECTIVES: To compare diffusion tensor (DT)-derived indices from the thalamic nuclei and cerebrospinal fluid (CSF) hydrodynamic parameters for the prediction of gait responsiveness to the CSF tap test in early iNPH patients. METHODS: In this study, 22 patients with iNPH and 16 normal controls were enrolled with the approval of an institutional review board. DT imaging and phase-contrast magnetic resonance imaging were performed in patients and controls to determine DT-related indices of the sensorimotor-related thalamic nuclei and CSF hydrodynamics...
May 7, 2018: European Radiology
Kurt Grahnke, Ignacio Jusue-Torres, Caroline Szujewski, Cara Joyce, Michael Schneck, Vikram Prabhu, Douglas Anderson
BACKGROUND: Diagnosing normal pressure hydrocephalus (NPH) and selecting patients who will experience a sustained benefit from fluid diversion surgery remains challenging. This study seeks to evaluate the association between the callosal angle (CA) and the long-term post-operative response to ventriculoperitoneal shunt (VPS) surgery in a different subgroup population than previously studied to assess its generalizability. METHODS: We studied 73 patients with idiopathic NPH who underwent VPS surgery and had at least 18 months of follow-up between 2000-2016...
April 30, 2018: World Neurosurgery
Alfonso Fasano, David F Tang-Wai
No abstract text is available yet for this article.
January 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Sami Abu Hamdeh, Ganna Shevchenko, Jia Mi, Sravani Musunuri, Jonas Bergquist, Niklas Marklund
The early molecular response to severe traumatic brain injury (TBI) was evaluated using biopsies of structurally normal-appearing cortex, obtained at location for intracranial pressure (ICP) monitoring, from 16 severe TBI patients. Mass spectrometry (MS; label free and stable isotope dimethyl labeling) quantitation proteomics showed a strikingly different molecular pattern in TBI in comparison to cortical biopsies from 11 idiopathic normal pressure hydrocephalus patients. Diffuse TBI showed increased expression of peptides related to neurodegeneration (Tau and Fascin, p < 0...
May 1, 2018: Scientific Reports
Chihiro Akiba, Madoka Nakajima, Masakazu Miyajima, Ikuko Ogino, Yumiko Motoi, Kaito Kawamura, Satoshi Adachi, Akihide Kondo, Hidenori Sugano, Takahiko Tokuda, Kazuhiro Irie, Hajime Arai
BACKGROUND: Alzheimer's disease (AD) pathology in idiopathic normal pressure hydrocephalus (iNPH) contributes to poor shunt responses. Amyloid-β 1- 42 (Aβ42) toxic conformer was recently identified with features of rapid oligomerization, strong neurotoxicity and synaptotoxicity. OBJECTIVE: This observational study points to Aβ42 toxic conformer as a biomarker for AD pathology and for poor postoperative prognosis in patients with iNPH. METHODS: The first cohort consisted of patients with AD (n = 17) and iNPH (n = 17), and cognitively normal individuals (CN, n = 12)...
April 25, 2018: Journal of Alzheimer's Disease: JAD
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