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https://www.readbyqxmd.com/read/29684922/saliva-versus-plasma-therapeutic-drug-monitoring-of-pregabalin-in-jordanian-patients
#1
Nasir Idkaidek, Salim Hamadi, Manal El-Assi, Ahmad Al-Shalalfeh, Ahmad Al-Ghazawi
The objective is using saliva instead of plasma for pregabalin therapeutic drug monitoring (TDM) since saliva reflects the free non-protein bound drug concentration, simple and noninvasive sampling, cheaper and does not require the expertise of drawing blood. Forty four patients participated in this study, two samples of saliva and another two of blood were taken from each patient; first sample of both saliva and blood is the trough sample and was taken just before the first dose of the day and second sample is the peak sample and was taken 1 h after taking the first dose of the day...
April 23, 2018: Drug Research
https://www.readbyqxmd.com/read/29684908/chemometrics-assisted-investigation-of-interactions-of-tasmar-with-human-serum-albumin-at-a-glassy-carbon-disk-application-to-electrochemical-biosensing-of-electro-inactive-serum-albumin
#2
Ghobad Mohammadi, Elahe Faramarzi, Majid Mahmoudi, Sirous Ghobadi, Ali Reza Ghiasvand, Hector C Goicoechea, Ali R Jalalvand
In this work, voltammetric data recorded by a glassy carbon electrode (GCE) was used to investigate the interactions of tolcapone (Tasmar, TAS) with human serum albumin (HSA) at the electrode surface. The recorded voltammetric data was also combined with spectroscopic data to construct an augmented data matrix which was analysed by multivariate curve resolution-alternating least squares (MCR-ALS) as an efficient chemometric tool to obtain more information about TAS-HSA interactions. The results of MCR-ALS confirmed formation of one complex species (HSA-TAS2 ) and application of MCR-BANDS to the results of MCR-ALS confirmed the absence of rotational ambiguities and existing unambiguous and reliable results...
April 17, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684903/repurposing-itraconazole-to-the-benefit-of-skin-cancer-treatment-a-combined-azole-ddab-nanoencapsulation-strategy
#3
C Carbone, C Martins-Gomes, V Pepe, A M Silva, T Musumeci, G Puglisi, P M Furneri, E B Souto
In this work, we aimed at developing an improved topical SLN formulation combining itraconazole delivery with a coating layer of didodecyldimethylammonium bromide, thus repurposing the drug effectiveness by synergistic skin anticancer effectiveness. In order to obtain a stable SLN formulation with small homogeneously dispersed particles, a deep formulative study was developed screening three different solid lipids (Suppocire NB, Cetyl Palmitate and Dynasan 114) for the SLN preparation by the phase inversion temperature...
April 17, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29684900/generation-of-the-human-induced-pluripotent-stem-cell-hipsc-line-psmi003-a-from-a-patient-affected-by-an-autosomal-recessive-form-of-long-qt-syndrome-type-1
#4
Manuela Mura, Monia Ginevrino, Rita Zappatore, Federica Pisano, Marina Boni, Silvia Castelletti, Lia Crotti, Enza Maria Valente, Peter J Schwartz, Massimiliano Gnecchi
We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a 51years old female patient homozygous for the mutation c.535 G>A p.G179S on the KCNQ1 gene, causing a severe form of autosomal recessive Long QT Syndrome type 1 (AR-LQT1), not associated with deafness. The hiPSCs, generated using four retroviruses each encoding for a reprogramming factor OCT4, SOX2, KLF4, cMYC, are pluripotent and can differentiate into spontaneously beating cardiomyocytes (hiPSC-CMs).
April 6, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29684897/reproductive-and-developmental-changes-in-tree-swallows-tachycineta-bicolor-are-influenced-by-multiple-stressors-including-polycyclic-aromatic-compounds-in-the-athabasca-oil-sands
#5
K J Fernie, S C Marteinson, C Soos, D Chen, L Cruz-Martinez, J E G Smits
Mining in the Athabasca Oil Sands Region (AOSR) has contributed extensively to increased exposure of wildlife to naturally occurring polycyclic aromatic compounds (PACs), yet little is known about the toxicity of PACs to wildlife in this region. We identified reproductive and developmental changes in tree swallows (Tachycineta bicolor) breeding in close proximity to mining-related activities in the AOSR, and determined these changes in relation to the birds' exposure and accumulation of 41 PACs (parent-, alkylated-PAHs), dibenzothiophenes (DBTs; previously published), diet (carbon (δ13 C), nitrogen (δ15 N)), volatile organic compounds, and weather variables...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684894/synthesis-and-biological-evaluation-of-2-6-disubstituted-9h-purine-2-4-disubstitued-thieno-3-2-d-pyrimidine-and-7h-pyrrolo-2-3-d-pyrimidine-analogues-as-novel-chk1-inhibitors
#6
Chao Tian, Zifei Han, Yuanxin Li, Meng Wang, Jiajia Yang, Xiaowei Wang, Zhili Zhang, Junyi Liu
Checkpoint kinase 1 (CHK1) inhibitors can potentiate the effectiveness of deoxyribonucleic acid (DNA) damaging agents in the treatment of cancer. A novel series of 2,6-disubstituted-9H-purine (3a-p, 5a and 5b), 2,4-disubstituted-thieno[3,2-d]pyrimidine (8a-c) and 2,4-disbustituted-7H-pyrrolo[2,3-d]pyrimidine (11a-c) analogues were designed and synthesized as potent CHK1 inhibitors. Compounds (3a, 3d, 3f and 3j-l) with 9H-purine core displayed more potent inhibition against CHK1. The most potent compound (3l) also exhibited low anti-proliferative effects towards HT29 and Hek293 cell lines...
March 28, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29684888/degree-of-phenyl-chlorination-of-ddt-related-compounds-as-potential-molecular-indicator-for-industrial-ddt-emissions
#7
Sebastian Kucher, Larissa Dsikowitzky, Mathias Ricking, Sujatha C H, Jan Schwarzbauer
The pesticide DDT (1-chloro-4-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl]benzene) and its degradates are among the most persistent and abundant organochlorine contaminates in the environment, and DDT is still being produced in several Asian countries. In this study, we report for the first time on the detection of DDT-related compounds with one additional or missing chlorine atom at the phenyl group (DDX±Cl ) in sediment and soil samples taken in the vicinity of former and current DDT production sites. These congeneric compounds most likely originate from production residues disposed of into the environment...
April 11, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29684883/cadmium-stabilization-via-silicates-formation-efficiency-reaction-routes-and-leaching-behavior-of-products
#8
Minhua Su, Jinfeng Tang, Changzhong Liao, Lingjun Kong, Tangfu Xiao, Kaimin Shih, Gang Song, Diyun Chen, Hongguo Zhang
Stabilizing cadmium by incorporating it into crystalline products is an effective approach to detoxify cadmium-containing wastes. In this study, two Si-rich matrices in amorphous and crystalline forms (i.e., silica fume and α-quartz, respectively) were employed to incorporate Cd. The processing parameters, namely the type of Si-rich matrix, Cd/Si molar ratio (Г) and sintering temperature, were thoroughly investigated using quantitative X-ray diffraction technique. Cd incorporation was more energetically favored when silica fume was used rather than when α-quartz was used because of the lower Gibbs free energy of formation for silica fume...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684877/toxicity-and-mutagenicity-of-exhaust-from-compressed-natural-gas-could-this-be-a-clean-solution-for-megacities-with-mixed-traffic-conditions
#9
Avinash K Agarwal, Bushra Ateeq, Tarun Gupta, Akhilendra P Singh, Swaroop K Pandey, Nikhil Sharma, Rashmi A Agarwal, Neeraj K Gupta, Hemant Sharma, Ayush Jain, Pravesh C Shukla
Despite intensive research carried out on particulates, correlation between engine-out particulate emissions and adverse health effects is not well understood yet. Particulate emissions hold enormous significance for mega-cities like Delhi that have immense traffic diversity. Entire public transportation system involving taxis, three-wheelers, and buses has been switched from conventional liquid fuels to compressed natural gas (CNG) in the Mega-city of Delhi. In this study, the particulate characterization was carried out on variety of engines including three diesel engines complying with Euro-II, Euro-III and Euro-IV emission norms, one Euro-II gasoline engine and one Euro-IV CNG engine...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684873/seabird-colonies-as-relevant-sources-of-pollutants-in-antarctic-ecosystems-part-1-trace-elements
#10
C V Z Cipro, P Bustamante, M V Petry, R C Montone
Global distillation is classically pointed as the biggest responsible for contaminant inputs in Polar ecosystems. Mercury (Hg) and other trace elements (TEs) also present natural sources, whereas the biologically mediated input is typically ignored. However, bioaccumulation and biomagnification combined with the fact that seabirds gather in large numbers into large colonies and excrete on land might represent an important local TEs input. A previous work suggested these colonies as sources of not only nutrients, but also organic contaminants...
March 24, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684866/the-mediation-roles-of-discrepancy-stress-and-self-esteem-between-masculine-role-discrepancy-and-mental-health-problems
#11
Xue Yang, Joseph T F Lau, Zixin Wang, Yee-Ling Ma, Mason C M Lau
INTRODUCTION: Masculine role discrepancy and discrepancy stress occur when men perceive that they fail to live up to the ideal manhood derived from societal prescriptions. The present study examined the associations between masculine role discrepancy and two emotional and mental health problems (social anxiety and depressive symptoms), and potential mediation effects through discrepancy stress and self-esteem in a male general population. METHODS: Based on random population-based sampling, 2000 male residents in Hong Kong were interviewed...
April 16, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29684858/a-novel-triazine-ring-compound-md568-exerts-in-vivo-and-in-vitro-effects-on-lipid-metabolism
#12
Dan Jia, Ziwen Li, Ying Gao, Yifan Feng, Weimin Li
In this study, we investigated the toxicity and biological activity of a novel triazine ring compound named magnolol derivative 568 (MD568). The LD50 of MD568 was determined in Sprague-Dawley (SD) rats by intraperitoneal injection. Treatment of high fat diet-induced obese rats with MD568 demonstrated that MD568 displayed significant anti-obesity effects. MD568 markedly reduced body weight, blood lipid contents, white adipose tissue (WAT) and liver mass in obese rats. In addition, MD568 modulated lesions in WAT through regulating PPAR-Ɣ, C/EBP-a, SREBP-1c and FABP-4 proteins in the liver through regulating PPAR-α, SREBP-1c and FABP-4...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684853/naringenin-improve-hepatitis-c-virus-infection-induced-insulin-resistance-by-increase-pten-expression-via-p53-dependent-manner
#13
Benli Jia, Dongsheng Yu, Gang Yu, Yunsheng Cheng, Yang Wang, Xiaoqiang Yi, Xiaoping Li, Yong Wang
Hepatitis C virus (HCV) infection may finally lead to hepatocellular carcinoma (HCC), and also associated with insulin resistance (IR). Naringenin (NGEN), a flavonoid found in grapefruit, has anti-virus, anti-inflammation and insulin sensitization effects. In the present study we examined the effects of NGEN on HCV core protein (HCVCP) infection induced IR and investigated the mechanism involved. We found that NGEN ameliorated IR and glucose tolerance in HCVCP infected mice by increase the phosphorylation of Akt at both Ser473 and Thr308 site, and also inhibited the inflammation cytokine production and T-cell immune response...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684839/effects-of-sous-vide-method-at-different-temperatures-times-and-vacuum-degrees-on-the-quality-structural-and-microbiological-properties-of-pork-ham
#14
Kiyoung Jeong, Hyeonbin O, So Yeon Shin, Young-Soon Kim
This study evaluated the influence of different factors on pork hams cooked by sous-vide method. The quality and structural and microbiological properties of the treated samples were compared with those of controls. Samples were subjected to treatment at different combinations of temperature (61 °C or 71 °C), time (45 or 90 min), and vacuum degree (98.81% or 96.58%). The control sample was air packaged and boiled for 45 min in boiling water. Temperature and vacuum degree affected quality properties, while the effect of time was limited...
April 10, 2018: Meat Science
https://www.readbyqxmd.com/read/29684818/glut1-protects-prostate-cancer-cells-from-glucose-deprivation-induced-oxidative-stress
#15
Pedro Gonzalez-Menendez, David Hevia, Rebeca Alonso-Arias, Alejandro Alvarez-Artime, Aida Rodriguez-Garcia, Sandrina Kinet, Ivan Gonzalez-Pola, Naomi Taylor, Juan C Mayo, Rosa M Sainz
Glucose, chief metabolic support for cancer cell survival and growth, is mainly imported into cells by facilitated glucose transporters (GLUTs). The increase in glucose uptake along with tumor progression is due to an increment of facilitative glucose transporters as GLUT1. GLUT1 prevents cell death of cancer cells caused by growth factors deprivation, but there is scarce information about its role on the damage caused by glucose deprivation, which usually occurs within the core of a growing tumor. In prostate cancer (PCa), GLUT1 is found in the most aggressive tumors, and it is regulated by androgens...
April 12, 2018: Redox Biology
https://www.readbyqxmd.com/read/29684810/associations-between-dairy-cow-inter-service-interval-and-probability-of-conception
#16
J G Remnant, M J Green, J N Huxley, C D Hudson
Recent research has indicated that the interval between inseminations in modern dairy cattle is often longer than the commonly accepted cycle length of 18-24 days. This study analysed 257,396 inseminations in 75,745 cows from 312 herds in England and Wales. The interval between subsequent inseminations in the same cow in the same lactation (inter-service interval, ISI) were calculated and inseminations categorised as successful or unsuccessful depending on whether there was a corresponding calving event. Conception risk was calculated for each individual ISI between 16 and 28 days...
April 11, 2018: Theriogenology
https://www.readbyqxmd.com/read/29684801/evaluation-of-racial-disparities-in-pediatric-optic-pathway-glioma-incidence-results-from-the-surveillance-epidemiology-and-end-results-program-2000-2014
#17
Erin C Peckham-Gregory, Roberto E Montenegro, David A Stevenson, David H Viskochil, Michael E Scheurer, Philip J Lupo, Joshua D Schiffman
BACKGROUND: Racial predilection to pediatric cancer exists; however optic pathway glioma (OPG) risk differences by race/ethnicity are undefined. We estimated differences in OPG incidence across racial/ethnic groups in a multi-state cancer surveillance registry in the United States. METHODS: OPG data were obtained from the Surveillance, Epidemiology, and End Results (SEER-18) Program, 2000-2014. Race/ethnicity was categorized as: White; Black; Asian; Other; and Latino/a ("Spanish-Hispanic-Latino")...
April 20, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29684800/ethnic-disparity-in-breast-cancer-survival-in-southern-thai-women
#18
Shama Virani, Elizabeth C Wetzel, Suphawat Laohawiriyakamol, Pleumjit Boonyaphiphat, Alan Geater, Celina G Kleer, Judy Pang, Katie M Rentschler, Justin A Colacino, Carlos F Mendes de Leon, Laura S Rozek, Hutcha Sriplung
BACKGROUND: Breast cancer has the highest incidence in women of all cancers and its burden is expected to continue to increase worldwide, especially in middle-income countries such as Thailand. The southern region of Thailand is unique in that it is comprised of 30% Muslims, whereas the rest of Thailand is 95% Buddhist. Breast cancer incidence and survival differ between these religious groups, but the association between clinical subtype of breast cancer and survival has not yet been assessed...
April 20, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29684789/bipedal-hopping-timed-to-a-metronome-to-detect-impairments-in-anticipatory-motor-control-in-people-with-mild-multiple-sclerosis
#19
Megan C Kirkland, Alice Chen, Matthew B Downer, Brett J Holloway, Elizabeth M Wallack, Evan J Lockyer, Natasha C M Buckle, Courtney L Abbott, Michelle Ploughman
BACKGROUND: People with mild multiple sclerosis (MS) often report subtle deficits in balance and cognition but display no measurable impairment on clinical assessments. We examined whether hopping to a metronome beat had the potential to detect anticipatory motor control deficits among people with mild MS (Expanded Disability Status Scale ≤ 3.5). METHODS: Participants with MS (n = 13), matched controls (n = 9), and elderly subjects (n = 13) completed tests of cognition (Montreal Cognitive Assessment (MoCA)) and motor performance (Timed 25 Foot Walk Test (T25FWT))...
April 13, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29684785/photoreceptor-calcium-sensor-proteins-in-detergent-resistant-membrane-rafts-are-regulated-via-binding-to-caveolin-1
#20
Vasiliy I Vladimirov, Evgeni Yu Zernii, Viktoriia E Baksheeva, Hanna Wimberg, Alexey S Kazakov, Natalya K Tikhomirova, Ekaterina L Nemashkalova, Vladimir A Mitkevich, Andrey A Zamyatnin, Valery M Lipkin, Pavel P Philippov, Sergei E Permyakov, Ivan I Senin, Karl-W Koch, Dmitry V Zinchenko
Rod cell membranes contain cholesterol-rich detergent-resistant membrane (DRM) rafts, which accumulate visual cascade proteins as well as proteins involved in regulation of phototransduction such as rhodopsin kinase and guanylate cyclases. Caveolin-1 is the major integral component of DRMs, possessing scaffolding and regulatory activities towards various signaling proteins. In this study, photoreceptor Ca2+ -binding proteins recoverin, NCS1, GCAP1, and GCAP2, belonging to neuronal calcium sensor (NCS) family, were recognized as novel caveolin-1 interacting partners...
April 14, 2018: Cell Calcium
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