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Cognitive Behavioral Therapy

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https://www.readbyqxmd.com/read/29341070/personality-changes-during-the-transition-from-cognitive-health-to-mild-cognitive-impairment
#1
Richard J Caselli, Blake T Langlais, Amylou C Dueck, Bruce R Henslin, Travis A Johnson, Bryan K Woodruff, Charlene Hoffman-Snyder, Dona E C Locke
BACKGROUND/OBJECTIVES: Behavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether personality changes that predispose to behavioral disorders arise during the transition from preclinical AD to mild cognitive impairment (MCI). DESIGN: Longitudinal observational cohort study...
January 17, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29338610/cns-side-effects-of-immune-checkpoint-inhibitors-preclinical-models-genetics-and-multimodality-therapy
#2
Gwendolyn J McGinnis, Jacob Raber
Following cancer treatment, patients often report behavioral and cognitive changes. Novel cancer immunotherapeutics have the potential to produce sustained cancer survivorship, meaning patients will live longer with the side effects of treatment. Given the role of inflammatory pathways in mediating behavioral and cognitive impairments seen in cancer, we aim in this review to discuss emerging evidence for the contribution of immune checkpoint blockade to exacerbate these CNS effects. We discuss ongoing studies regarding the ability of immune checkpoint inhibitors to reach the brain and how treatment responses to checkpoint inhibitors may be modulated by genetic factors...
September 2017: Immunotherapy
https://www.readbyqxmd.com/read/29335846/cotinine-a-therapy-for-memory-extinction-in-post-traumatic-stress-disorder
#3
REVIEW
Cristhian Mendoza, George E Barreto, Alexandre Iarkov, Vadim V Tarasov, Gjumrakch Aliev, Valentina Echeverria
Post-traumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally threatening or unescapable horrifying events. Actual therapies fail to alleviate the emotional suffering and cognitive impairment associated with this disorder, mostly because they are ineffective in treating the failure to extinguish trauma memories in a great percentage of those affected. In this review, current behavioral, cellular, and molecular evidence supporting the use of cotinine for treating PTSD are reviewed...
January 15, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29335826/high-salt-and-cholesterol-diet-associated-cognitive-impairment-attenuated-by-tannins-enriched-fraction-of-emblica-officinalis-via-inhibiting-nf-kb-pathway
#4
Ibraheem Husain, Mohd Akhtar, Mohammad Shaharyar, Mohammad Islamuddin, Malik Zainul Abdin, Mohd Jawaid Akhtar, Abul Kalam Najmi
Metabolic disorders are closely associated with dietary habits and seem to be related to neuroinflammation and neurodegenerative disease in humans. Emblica officinalis (EOT) fruits not only have good nutritional value but also have excellent therapeutic potential. We used a tannins-enriched fraction of EOT fruit with the expectation of controlling diet-induced neuroinflammation and cognitive impairment in rats. A high-salt and cholesterol diet (HSCD) was used to induce neuroinflammation and cognitive impairment in rats...
January 15, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29335360/activity-in-the-ventral-medial-prefrontal-cortex-is-necessary-for-the-therapeutic-effects-of-extinction-in-rats
#5
Elizabeth A Fucich, Denisse Paredes, Madeleine O Saunders, David A Morilak
Poor response and high relapse rates remain problematic in the treatment of stress-related psychiatric disorders like depression and posttraumatic stress disorder (PTSD). While mechanisms of pharmacotherapies are intensely studied, little is known about mechanisms of behavioral therapy that could inform improved treatments. We have previously demonstrated the therapeutic effects of extinction learning as a behavioral intervention modeling exposure therapy in rats. In the present study, we tested the hypothesis that activity in the ventral medial prefrontal cortex (vmPFC) during extinction is necessary for its therapeutic effects...
January 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29335233/internet-based-group-intervention-for-ovarian-cancer-survivors-feasibility-and-preliminary-results
#6
Ellen M Kinner, Jessica S Armer, Bonnie A McGregor, Jennifer Duffecy, Susan Leighton, Marya E Corden, Janine Gauthier Mullady, Frank J Penedo, Susan K Lutgendorf
BACKGROUND: Development of psychosocial group interventions for ovarian cancer survivors has been limited. Drawing from elements of cognitive-behavioral stress management (CBSM), mindfulness-based stress reduction (MBSR), and acceptance and commitment therapy (ACT), we developed and conducted preliminary testing of an Internet-based group intervention tailored specifically to meet the needs of ovarian cancer survivors. The Internet-based platform facilitated home delivery of the psychosocial intervention to a group of cancer survivors for whom attending face-to-face programs could be difficult given their physical limitations and the small number of ovarian cancer survivors at any one treatment site...
January 15, 2018: JMIR Cancer
https://www.readbyqxmd.com/read/29335209/chameleon-like-behavior-of-indolylpiperidines-in-complex-with-cholinesterases-targets-potent-butyrylcholinesterase-inhibitors
#7
Talita P C Chierrito, Susimaire Pedersoli-Mantoani, Carlos Roca, Victor Sebastian-Pérez, Loreto Martínez-Gonzalez, Daniel I Pérez, Concepción Perez, Angeles Canales, F Javier Cañada, Nuria E Campillo, Ivone Carvalho, Ana Martinez
Alzheimer's disease (AD) is the most common form of dementia worldwide with an increasing prevalence for the next years. The multifactorial nature of AD precludes the design of new drugs directed to a single target being probably one of the reasons for recent failures. Therefore, dual binding site acetylcholinesterase (AChE) inhibitors have been revealed as cognitive enhancers and β-amyloid modulators offering an alternative in AD therapy field. Based on the dual ligands NP61 and donepezil, the present study reports the synthesis of a series of indolylpiperidines hybrids to optimize the NP61 structure preserving the indole nucleus, but replacing the tacrine moiety of NP61 by benzyl piperidine core found in donepezil...
January 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29333504/community-based-physical-activity-as-adjunctive-smoking-cessation-treatment-rationale-design-and-baseline-data-for-the-lifestyle-enhancement-program-leap-randomized-controlled-trial
#8
Mark W Vander Weg, Mace Coday, Michelle B Stockton, Barbara McClanahan, George Relyea, Mary C Read, Nancy Wilson, Stephanie Connelly, Phyllis Richey, Karen C Johnson, Kenneth D Ward
Despite advances in behavioral and pharmacological treatment for tobacco use and dependence, quit rates remain suboptimal. Increasing physical activity has shown some promise as a strategy for improving cessation outcomes. However, initial efficacy studies focused on intensive, highly structured exercise programs that may not be applicable to the general population of smokers. We describe the rationale and study design and report baseline participant characteristics from the Lifestyle Enhancement Program (LEAP), a two-group, randomized controlled trial...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29331692/memory-performance-predicts-response-to-psychotherapy-for-depression-in-bipolar-disorder-a-pilot-randomized-controlled-trial-with-exploratory-functional-magnetic-resonance-imaging
#9
Thilo Deckersbach, Amy T Peters, Conor Shea, Aishwarya Gosai, Jonathan P Stange, Andrew D Peckham, Kristen K Ellard, Michael W Otto, Scott L Rauch, Darin D Dougherty, Andrew A Nierenberg
OBJECTIVE: This pilot randomized controlled trial compared Cognitive Behavior Therapy (CBT) and Supportive Psychotherapy (SP) for the treatment of depression in bipolar I disorder. We also examined whether exploratory verbal memory, executive functioning, and neural correlates of verbal memory during functional magnetic resonance imaging (fMRI) predicted change in depression severity. METHODS: Thirty-two adults (ages 18-65) with DSM-IV bipolar I disorder meeting current criteria for a major depressive episode were randomized to 18 weeks of CBT or SP...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331172/blood-phenylalanine-reduction-corrects-cns-dopamine-and-serotonin-deficiencies-and-partially-improves-behavioral-performance-in-adult-phenylketonuric-mice
#10
Shelley R Winn, Tanja Scherer, Beat Thöny, Ming Ying, Aurora Martinez, Sydney Weber, Jacob Raber, Cary O Harding
Central nervous system (CNS) deficiencies of the monoamine neurotransmitters dopamine and serotonin have been implicated in the pathophysiology of neuropsychiatric dysfunction in human phenylketonuria (PKU). In this study, we confirmed the occurrence of brain dopamine and serotonin deficiencies in association with severe behavioral alterations and cognitive impairments in hyperphenylalaninemic C57BL/6-Pahenu2/enu2 mice, a model of human PKU. Phenylalanine-reducing treatments, including either dietary phenylalanine restriction or liver-directed gene therapy, initiated during adulthood were associated with increased brain monoamine content along with improvements in nesting behavior but without a change in the severe cognitive deficits exhibited by these mice...
January 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29329597/does-cognitive-behavioral-therapy-alter-mental-defeat-and-cognitive-flexibility-in-patients-with-panic-disorder
#11
Shinobu Nagata, Yoichi Seki, Takayuki Shibuya, Mizue Yokoo, Tomokazu Murata, Yoichi Hiramatsu, Fuminori Yamada, Hanae Ibuki, Noriko Minamitani, Naoki Yoshinaga, Muga Kusunoki, Yasushi Inada, Nobuko Kawasoe, Soichiro Adachi, Keiko Oshiro, Daisuke Matsuzawa, Yoshiyuki Hirano, Kensuke Yoshimura, Michiko Nakazato, Masaomi Iyo, Akiko Nakagawa, Eiji Shimizu
OBJECTIVE: Mental defeat and cognitive flexibility have been studied as explanatory factors for depression and posttraumatic stress disorder. This study examined mental defeat and cognitive flexibility scores in patients with panic disorder (PD) before and after cognitive behavioral therapy (CBT), and compared them to those of a gender- and age-matched healthy control group. RESULTS: Patients with PD (n = 15) received 16 weekly individual CBT sessions, and the control group (n = 35) received no treatment...
January 12, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29326098/cognitive-and-behavioral-skills-exercises-completed-by-patients-with-major-depression-during-smartphone-cognitive-behavioral-therapy-secondary-analysis-of-a-randomized-controlled-trial
#12
Toshi A Furukawa, Masaru Horikoshi, Hirokazu Fujita, Naohisa Tsujino, Ran Jinnin, Yuki Kako, Sei Ogawa, Hirotoshi Sato, Nobuki Kitagawa, Yoshihiro Shinagawa, Yoshio Ikeda, Hissei Imai, Aran Tajika, Yusuke Ogawa, Tatsuo Akechi, Mitsuhiko Yamada, Shinji Shimodera, Norio Watanabe, Masatoshi Inagaki, Akio Hasegawa
BACKGROUND: A strong and growing body of evidence has demonstrated the effectiveness of cognitive behavioral therapy (CBT), either face-to-face, in person, or as self-help via the Internet, for depression. However, CBT is a complex intervention consisting of several putatively effective components, and how each component may or may not contribute to the overall effectiveness of CBT is poorly understood. OBJECTIVE: The aim of this study was to investigate how the users of smartphone CBT use and benefit from various components of the program...
January 11, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29324745/proof-of-concept-study-of-an-at-home-engaging-digital-intervention-for-pediatric-adhd
#13
Naomi O Davis, Jeffrey Bower, Scott H Kollins
OBJECTIVE: Pharmacological and behavioral therapies have limited impact on the distinct neurocognitive impairments associated with ADHD, and existing cognitive training programs have shown limited efficacy. This proof-of-concept study assessed treatment acceptability and explored outcomes for a novel digital treatment targeting cognitive processes implicated in ADHD. METHOD: Participants included 40 children with ADHD and 40 children without ADHD. Following psychiatric screening, ADHD ratings, and baseline neuropsychological measures, participants completed 28-days of at-home treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29323626/a-scenario-based-cognitive-behavioral-therapy-mobile-app-to-reduce-dysfunctional-beliefs-in-individuals-with-depression-a-randomized-controlled-trial
#14
Ji-Won Hur, Boram Kim, Dasom Park, Sung-Won Choi
INTRODUCTION: While self-administered mobile app-based cognitive behavioral therapy (CBT) has shown efficiency and effectiveness over the past decade, attempts to address automatic and negative beliefs have been lacking. The purpose of this study was to introduce and verify a mobile app that directly intervenes in dysfunctional thoughts. This app-based treatment includes recognizing automatic and negative thoughts of the protagonist of scenarios, writing advice directly to the main character, and sharing advice provided by other participants...
January 11, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29320382/two-new-psychotherapy-studies-back-to-the-future
#15
Eric M Plakun
This column reviews 2 recent high-quality psychotherapy research studies. One study by Steinert and colleagues suggests that psychodynamic therapy is equivalent to cognitive behavioral therapy (CBT) (or medication when this was the comparator) for a range of disorders. A second study by Barlow and colleagues finds Unified Protocol CBT targeting underlying emotional dysregulation to be equivalent to single disorder-specific CBT for a range of anxiety disorders. Taken together, these studies help bridge the gap between CBT and psychodynamic therapy and refocus us on the realities of clinical settings, where most patients present with multiple comorbid disorders...
January 2018: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29318978/cognitive-rehabilitation-of-cerebellar-deficits
#16
Peter Marien, Kim van Dun, Frank Van Overwalle
During the past 3 decades numerous neurophysiological, neuroimaging, experimental and clinical studies have evidenced a crucial role for the cerebellum in cognitive, affective and behavioral functions. As a result of the acknowledged modulatory role of the cerebellum upon remote structures such as the cerebral cortex, cerebellar injury may give rise to a constellation of behavioral, affective and cognitive symptoms (Schmahmann's Syndrome). In sharp contrast to the wide range of therapeutical interventions to treat cognitive and affective disorders following cerebral cortical lesions and despite the consequences of Schmahmann's syndrome upon daily life activities, the literature is surprisingly only scantly documented with studies investigating the impact of cognitive therapies on cerebellar induced cognitive and affective disorders...
January 10, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29315132/self-help-cognitive-behavior-therapy-for-working-women-with-problematic-hot-flushes-and-night-sweats-menos-work-a-multicenter-randomized-controlled-trial
#17
Claire Hardy, Amanda Griffiths, Sam Norton, Myra S Hunter
OBJECTIVE: The aim of the study was to examine the efficacy of an unguided, self-help cognitive behavior therapy (SH-CBT) booklet on hot flush and night sweat (HFNS) problem rating, delivered in a work setting. METHODS: Women aged 45 to 60 years, having 10 or more problematic HFNS a week, were recruited to a multicenter randomized controlled trial, via the occupational health/human resources departments of eight organizations. Participants were 1:1 randomized to SH-CBT or no treatment waitlist control (NTWC)...
January 8, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29313400/gofar-improving-attention-behavior-and-adaptive-functioning-in-children-with-fetal-alcohol-spectrum-disorders-brief-report
#18
Claire D Coles, Julie A Kable, Elles Taddeo, Dorothy Strickland
OBJECTIVE: This brief report describes the GoFAR intervention designed to improve attention, behavior, and adaptive functioning in children with FASD, ages 5 to 10 years. METHODS: Thirty children were randomized to one of three conditions: GoFAR; FACELAND, and CONTROL; 25 completed the interventions. Over 10 sessions children and caregivers learned a metacognitive strategy (FAR) designed to improve cognitive control of behavior and adaptive functioning and practiced it during behavior analog therapy...
January 9, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29309954/impaired-theory-of-mind-in-chinese-children-and-adolescents-with-idiopathic-generalized-epilepsy-association-with-behavioral-manifestations-of-executive-dysfunction
#19
Ting Zhang, Lingyan Chen, Yu Wang, Mengmeng Zhang, Lanlan Wang, Xiangjun Xu, Gairong Xiao, Jing Chen, Yeru Shen, Nong Zhou
BACKGROUND: Epilepsy is a common neurological disorder with a core feature of cognitive impairments. Previous studies showed that patients with focal epilepsy have deficits in both theory of mind (ToM) and executive function (EF). However, there are few studies of ToM in patients with idiopathic generalized epilepsy (IGE), especially in populations with pediatric epilepsy. The aim of this study was to examine the characteristics of ToM and EF, including some of their subcomponents, and explore the relationship between them in Chinese children with IGE...
January 5, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29309797/treatment-of-pandas-and-pans-a-systematic-review
#20
REVIEW
Sofia Sigra, Eva Hesselmark, Susanne Bejerot
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are a subtype of acute-onset obsessive-compulsive disorder (OCD) thought to be caused by an autoimmune response to group A streptococcal infection. Based on this proposed pathophysiology, alternative treatments for acute-onset OCD have been introduced, including antibiotics and immunomodulatory interventions. However, the literature on treatment of PANDAS is diverse, and clinical consensus regarding optimal treatment strategy is lacking...
January 5, 2018: Neuroscience and Biobehavioral Reviews
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