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https://www.readbyqxmd.com/read/26738855/anthocyanins-reversed-d-galactose-induced-oxidative-stress-and-neuroinflammation-mediated-cognitive-impairment-in-adult-rats
#1
Shafiq Ur Rehman, Shahid Ali Shah, Tahir Ali, Jong Il Chung, Myeong Ok Kim
Aging is a major factor involved in neurological impairments, decreased anti-oxidant activities, and enhanced neuroinflammation. D-galactose (D-gal) has been considered an artificial aging model which induces oxidative stress and inflammatory response resulting in memory and synaptic dysfunction. Dietary supplementation exerts valuable effects against oxidative stress and neuroinflammation. Polyphenolic flavonoids, such as anthocyanins, have been reported as an anti-inflammatory and anti-oxidant agents against various neurodegenerative diseases...
January 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/24978050/-the-role-of-alpha-synuclein-in-parkinson-s-disease
#2
REVIEW
Ildikó Miklya, Noémi Pencz, Florencia Hafenscher, Patricia Göltl
α-synuclein, a small protein (140 amino acids) encoded by the SNCA gene is the best known isoform of the synuclein protein family. Though its physiological role is still not fully clarified, there is growing experimental evidence for a causal role of α-synuclein in the so-called conformational-neurodegenerative diseases. Conformational changes in the structure of the native soluble protein form insoluble neurotoxic aggregates and finally contribute to the formation of inclusion Lewy-bodies and Lewy-neurites...
June 2014: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/24599628/indole-and-trans-chalcone-attenuate-amyloid-%C3%AE-plaque-accumulation-in-male-wistar-rat-in-vivo-effectiveness-of-two-anti-amyloid-scaffolds
#3
RANDOMIZED CONTROLLED TRIAL
Parichehreh Yaghmaei, Raheleh Kheirbakhsh, Mehrooz Dezfulian, Ali Haeri-Rohani, Bagher Larijani, Azadeh Ebrahim-Habibi
Alzheimer's disease (AD) is an irreversible neurodegenerative condition in which abnormal accumulation of amyloid plaques is observed, and for which no effective treatment still exist. In recent years, many aromatic small molecules have been observed to have anti-amyloid effect, and may have the potential to attenuate AD symptoms. The indole core and the flavonoid precursor trans-chalcone have been studied here as representative of these group of molecules. Formation of amyloid plaques has been induced in a rat model of AD, after what the two compounds were given to experimental groups...
September 2013: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/24398936/ischemia-reperfusion-injury-induces-occludin-phosphorylation-ubiquitination-and-retinal-vascular-permeability-in-a-vegfr-2-dependent-manner
#4
Arivalagan Muthusamy, Cheng-Mao Lin, Sumathi Shanmugam, Heather M Lindner, Steven F Abcouwer, David A Antonetti
Retinal ischemia-reperfusion (IR) induces neurodegenaration as well as blood-retinal barrier (BRB) breakdown causing vascular permeability. Whereas the neuronal death has been extensively studied, the molecular mechanisms related to BRB breakdown in IR injury remain poorly understood. In this study, we investigated the early changes in tight junctional (TJ) proteins in response to IR injury. Ischemia-reperfusion injury was induced in male rat retinas by increasing the intraocular pressure for 45 minutes followed by natural reperfusion...
March 2014: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/24167945/-homocysteine-and-its-role-in-pathogenesis-of-parkinson-s-disease-and-other-neurodegenerative-disorders
#5
Karol Szadejko, Krzysztof Szabat, Anna Ludwichowska, Jarosław Sławek
Homocysteine (Hcy) has recently become the focus of interest in the research on Parkinson's disease (PD) and other neurodegenarative disorders. Chronic treatment with levodopa (LD), considered the standard treatment for PD, leads to an increase in homocysteine concentration in serum and cerebro-spinal fluid. Independently from this effect, homocysteine is also regarded as a marker of neurodegenerative disorders. Main interest was focused on hyperhomocysteinemia (hHcy) as the potential risk factor for atheromatosis...
2013: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/23011427/-the-neurodegenerative-process-in-multiple-sclerosis-and-the-possible-neuroprotective-effect-of-treatment-with-%C3%AE-interferon-1a-avonex
#6
M V Davydovskaia, A N Boĭko, A E Podoprigora, I N Pronin, V N Kornienko, E I Gusev
The aim of the study was to investigate the change of NAA/Cr ratio in the brain parenchyma in patients with MS with the help of protonic multivoxel magnetic resonance spectroscopy (PMMRS) and to detect the correlation between this factor and clinical status of the patients. The study was also performed in order to investigate whether this method can be potentially used for monitoring of the severity of the disease and severity of the neurodegenerative process. On the basis of this knowledge potential neuroprotective effect of the interferon beta 1a (IFN Β1а) i...
2012: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/22297753/protective-effects-of-acetyl-l-carnitine-on-neurodegenarative-changes-in-chronic-cerebral-ischemia-models-and-learning-memory-impairment-in-aged-rats
#7
Moon-Jung Goo, Seul Min Choi, Soon-Hoe Kim, Byoung Ok Ahn
This study investigated the effects of acetyl-L-carnitine (ALC) in secondarily-induced cerebral chronic ischemia models using rats with permanent ligation of bilateral common carotid arteries (BCCL) and spontaneously hypertensive rats (SHR). Additionally, we used normal aged rats as a primary dementia model. Chronic ALC administration at 100 mg/kg (p.o.) for 4 weeks significantly attenuated neurodegenerative changes. In groups receiving 50 mg/kg or 100 mg/kg, ALC inhibited the active astrocyte increase in cerebral tissues of both BCCL and SHR models...
January 2012: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/22144773/neuroprotective-activity-of-wedelia-calendulacea-on-cerebral-ischemia-reperfusion-induced-oxidative-stress-in-rats
#8
Tigari Prakash, Dupadahalli Kotresha, Rama Rao Nedendla
OBJECTIVE: This study was undertaken to evaluate the neuroprotective activity of Wedelia calendulacea against cerebral ischemia/reperfusion induced oxidative stress in the rats. MATERIALS AND METHODS: The global cerebral ischemia was induced in male albino Wistar rats by occluding the bilateral carotid arteries for 30 min followed by 1 h and 4 h reperfusion. At various times of reperfusion, the histopathological changes and the levels of malondialdehyde (MDA), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-s-transferase (GST), and hydrogen peroxide (H(2)O(2)) activity and brain water content were measured...
November 2011: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/22138428/theaflavin-a-black-tea-polyphenol-protects-nigral-dopaminergic-neurons-against-chronic-mptp-probenecid-induced-parkinson-s-disease
#9
Annadurai Anandhan, Kuppusamy Tamilselvam, Thangaiyan Radhiga, Shalinee Rao, Musthafa Mohamed Essa, Thamilarasan Manivasagam
Parkinson's disease (PD) is a progressive neurodegenerative disorder, characterized by loss of dopominergic neurons in substantia nigra pars compacta, and can be experimentally induced by the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Chronic administration of MPTP/probenecid (MPTP/p) leads to oxidative stress, induction of apoptosis, and loss of dopominergic neurons which results in motor impairments. Epidemiological studies have shown an inverse relationship between tea consumption and susceptibility to PD...
January 18, 2012: Brain Research
https://www.readbyqxmd.com/read/21073741/nigrostriatal-neuronal-death-following-chronic-dichlorvos-exposure-crosstalk-between-mitochondrial-impairments-%C3%AE-synuclein-aggregation-oxidative-damage-and-behavioral-changes
#10
B K Binukumar, Amanjit Bal, Ramesh J L Kandimalla, Kiran Dip Gill
BACKGROUND: In recent years, several lines of evidence have shown an increase in Parkinson's disease prevalence in rural environments where pesticides are heavily used. Although, the underlying mechanism for neuronal degeneration in sporadic PD remains unknown, mitochondrial dysfunction, oxidative stress and proteasomal dysfunction are proposed as contributing factors. In this study rats were chronically and continuously exposed to the pesticide, dichlorvos to identify the molecular mechanism of nigrostaital neuronal degeneration...
2010: Molecular Brain
https://www.readbyqxmd.com/read/18683964/proteome-response-to-the-panneural-expression-of-human-wild-type-alpha-synuclein-a-drosophila-model-of-parkinson-s-disease
#11
Zhiyin Xun, Thomas C Kaufman, David E Clemmer
The alpha-synuclein protein is associated with several neurodegenarative diseases, including Parkinson's disease (PD). In humans, only mutated forms of alpha-synuclein are linked to PD; however, panneural expression of human wild-type (WT) alpha-synuclein induces Parkinson's like-symptoms in Drosophila. Here, we report a quantitative proteomic analysis of WT alpha-synuclein transgenic flies with age-matched controls at the presymptomatic stage utilizing a global isotopic labeling strategy combined with multidimensional liquid chromatographies and tandem mass spectrometry...
September 2008: Journal of Proteome Research
https://www.readbyqxmd.com/read/17613115/an-olfactory-bulbectomy-model-to-study-plasticity-of-the-nervous-system-in-rat-a-review-focused-on-published-data-from-the-slovak-republic
#12
REVIEW
Enikö Raceková, Judita Orendácová
This review surveys the main data published at the Institute of Neurobiology, Slovak Republic, pertaining to both morphological and functional observations in the olfactory bulbectomy model. The review utilized this experimental approach in homo- and heterotopic transplantations, in experiments for studying neurodegenaration/regeneration and phenomena of adult neurogenesis. The results, discussed in context of relevant literary data, indicate that the model of olfactory bulbectomy can be utilized to investigate problems not only related to the olfactory system but it can also address the problems of neuronal development, neuronal plasticity and interaction concerning the nervous system as a whole...
August 2007: International Journal of Neuroscience
https://www.readbyqxmd.com/read/17612594/protective-effect-of-erythropoietin-against-1-methyl-4-phenylpyridinium-induced-neurodegenaration-in-pc12-cells
#13
Yan Wu, You Shang, Sheng-Gang Sun, Ren-Gang Liu, Wen-Qiong Yang
OBJECTIVE: The neuroprotective effect of erythropoietin (EPO) against 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress in cultured PC12 cells, as well as the underlying mechanism, were investigated. METHODS: PC12 cells impaired by MPP(+) were used as the cell model of Parkinson's disease. Methyl thiazolyl tetrazolium (MTT) was used to assay the viability of the PC12 cells exposed to gradient concentrations of EPO, and the terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay was used to analyze the apoptosis ratio of PC12 cells...
May 2007: Neuroscience Bulletin
https://www.readbyqxmd.com/read/17584612/specific-inhibition-of-p300-hat-alters-global-gene-expression-and-represses-hiv-replication
#14
K Mantelingu, B A Ashok Reddy, V Swaminathan, A Hari Kishore, Nagadenahalli B Siddappa, G V Pavan Kumar, G Nagashankar, Nagashayana Natesh, Siddhartha Roy, Parag P Sadhale, Udaykumar Ranga, Chandrabhas Narayana, Tapas K Kundu
Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, diabetes, AIDS, and cardiac hypertrophy. We describe the synthesis and characterization of a set of p300-HAT-specific small-molecule inhibitors from a natural nonspecific HAT inhibitor, garcinol, which is highly toxic to cells. We show that the specific inhibitor selectively represses the p300-mediated acetylation of p53 in vivo...
June 2007: Chemistry & Biology
https://www.readbyqxmd.com/read/16828080/neuroprotective-effects-of-thymoquinone-against-transient-forebrain-ischemia-in-the-rat-hippocampus
#15
COMPARATIVE STUDY
Abdulhakeem A Al-Majed, Fadhel A Al-Omar, Mahmoud N Nagi
Increasing evidence demonstrates that oxidative stress plays an important role in brain injury in experimental models of brain ischemia. Thymoquinone, the main constituents of the volatile oil from Negella sativa seeds, is reported to possess strong antioxidant properties. Hence, the present study was undertaken to evaluate the neuroprotective effect of thymoquinone against transient forebrain ischemia-induced neuronal damage in the rat hippocampus. Rats were divided randomly into five groups: control, sham, ischemia, thymoquinone and ischemia+thymoquinone...
August 14, 2006: European Journal of Pharmacology
https://www.readbyqxmd.com/read/16515537/the-mechanism-of-1-2-3-4-tetrahydroisoquinolines-neuroprotection-the-importance-of-free-radicals-scavenging-properties-and-inhibition-of-glutamate-induced-excitotoxicity
#16
COMPARATIVE STUDY
Lucyna Antkiewicz-Michaluk, Jerzy W Lazarewicz, Antoni Patsenka, Malgorzata Kajta, Elzbieta Zieminska, Elzbieta Salinska, Agnieszka Wasik, Krystyna Golembiowska, Jerzy Vetulani
1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), unlike several other tetrahydroisoquinolines, displays neuroprotective properties. To elucidate this action we compared the effects of 1MeTIQ with 1,2,3,4-tetrahydroisoquinoline (TIQ), a compound sharing many activities with 1MeTIQ (among them reducing free radicals formed during dopamine catabolism), but offering no clear neuroprotection. We found that the compounds similarly inhibit free-radical generation in an abiotic system, as well as indices of neurotoxicity (caspase-3 activity and lactate dehydrogenase release) induced by glutamate in mouse embryonic primary cell cultures (a preparation resistant to NMDA toxicity)...
May 2006: Journal of Neurochemistry
https://www.readbyqxmd.com/read/16236368/protective-effects-of-erythropoietin-against-ethanol-induced-apoptotic-neurodegenaration-and-oxidative-stress-in-the-developing-c57bl-6-mouse-brain
#17
COMPARATIVE STUDY
Abdullah Kumral, Kazim Tugyan, Sevil Gonenc, Kursat Genc, Sermin Genc, Ulker Sonmez, Osman Yilmaz, Nuray Duman, Nazan Uysal, Hasan Ozkan
The developing central nervous system is extremely sensitive to ethanol, with well-defined temporal periods of vulnerability. Recent studies have shown that administration of ethanol to infant rats during the synaptogenesis period triggers extensive apoptotic neurodegeneration throughout many regions of the developing brain. Furthermore, acute ethanol administration produces lipid peroxidation in the brain as an indicator of oxidative stress. In recent years, it has been shown that erythropoietin (EPO) has a critical role in the development, maintenance, protection, and repair of the nervous system...
December 7, 2005: Brain Research. Developmental Brain Research
https://www.readbyqxmd.com/read/16215768/inhibitors-of-proprotein-convertases
#18
REVIEW
Ajoy Basak
The discovery of mammalian subtilases, proprotein convertases (PCs) or subtilisin-like proprotein convertases (SPCs), in 1990 was a result of sustained efforts in searching for enzyme/s responsible for maturation of inactive protein precursors. Since then, seven PCs have so far been discovered that cleave at the carboxy-terminal of a basic amino acid characterized by the consensus sequence Arg/Lys/His-X-X/Lys/Arg-Arg downward arrow, where X denotes any amino acid other than Cys. Two additional PC subtypes--called subtilisin kexin isozyme 1 (SKI-1) or site 1 protease (S1P) and neural apoptosis regulated convertase 1 (NARC-1), also known as PCSK9--that cleave at the carboxy terminus of nonbasic amino acids were discovered later...
November 2005: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/15248866/behavioural-profiles-of-inbred-mouse-strains-used-as-transgenic-backgrounds-i-motor-tests
#19
COMPARATIVE STUDY
S P Brooks, T Pask, L Jones, S B Dunnett
One of the characteristic manifestations in several neurodegenarative diseases is the loss of voluntary motor control and the development of involuntary movements. In order to determine the suitability of six mouse strains as transgenic background strains we investigated performance on a variety of tasks designed to identify subtle changes in motor control. On both the accelerating and the staggered speed rotarod all six mouse strains performed well. However, latency to fall from the rod was sensitive to both rotarod speed and repeated exposure to the apparatus...
August 2004: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/12804790/neurodegeneration-of-substantia-nigra-accompanied-with-macrophage-microglia-infiltration-after-intrastriatal-hemorrhage
#20
COMPARATIVE STUDY
Nobuki Imamura, Hideki Hida, Noritaka Aihara, Kazuto Ishida, Yoshie Kanda, Hitoo Nishino, Kazuo Yamada
Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the expression of both brain-derived neurotrophic factor (BDNF) mRNA and BDNF, suggesting that activated-p38 MAPK(+)/ED1(+) cells would produce BDNF and may exhibit trophic effect on the degenerating neurons in the SN...
July 2003: Neuroscience Research
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