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https://www.readbyqxmd.com/read/27922336/abscopal-regression-following-sabr-for-non-small-cell-lung-cancer-a-case-report
#1
Yang Cong, Ge Shen, Shikai Wu, Ruimin Hao
Out-of-field tumor response, which is also called abscopal effect, bystander effect, or non-target effect, can be regarded as localized irradiation induced systemic antitumorigenic effects, indicating shrinkage of a tumor distant from the irradiated site. Although abscopal effect has been documented in several tumor types, it is a very rare phenomenon which is clinically reported in non-small-cell-lung carcinoma (NSCLC). Herein, we represent a rare case of patient with NSCLC with two lesions in the upper lobe of left lung who, after receiving stereotactic ablative radiation therapy (SABR) to one of the tumors, had an apparent spontaneous regression of the other mass in the lung, suggestive of a radiation-induced abscopal effect...
December 6, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27921123/local-control-and-intermediate-term-cosmetic-outcome-following-imrt-for-nasal-tumors-an-update
#2
Yuki Mukai, Stefan Janssen, Christoph Glanzmann, David Holzmann, Gabriela Studer
OBJECTIVE: This study aims to evaluate local control and intermediate-term cosmetic outcome in patients with cancer of the nose treated with intensity-modulated radiotherapy (IMRT). METHODS: From June 2008 to September 2015, 36 consecutive patients presenting with nasal cavity, ala of the nose, or nasal vestibule tumors were treated at the Department of Radiation Oncology, University Hospital Zurich either postoperatively (n = 14; 3/14 with nasal ablation) or with definitive IMRT (n = 22)...
December 5, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27920681/a-rare-case-of-mycosis-fungoides-in-the-oral-cavity-and-small-intestine-complicated-by-perforation
#3
Drew Arthur Emge, Juri Bassuner, Daniel J Lewis, Madeleine Duvic
Extracutaneous involvement in mycosis fungoides (MF) carries a poor prognosis. Oral and gastrointestinal (GI) tract lesions are both rare locations of disease. We describe the clinical findings of one case with oral and GI MF complicated by perforation after systemic antineoplastic treatment, and review the relevant literature. The patient had a 1-year history of MF before development of tongue and palate tumors. He was treated with local electron beam radiation, but re-presented to the hospital after what was found to be small intestine perforation following systemic antineoplastic therapy...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/27912833/treatment-of-locally-advanced-non-small-cell-lung-cancer
#4
REVIEW
Kit Tam, Megan Daly, Karen Kelly
Locally advanced non-small cell lung cancer is a heterogeneous disease with typically poor outcomes. Select patients may benefit from the integration of surgery, whereas patients with bulky, multistation, or contralateral (N3) mediastinal involvement are managed with definitive chemoradiation. Attempts to improve outcomes through induction, consolidation, or maintenance chemotherapy or radiation dose escalation have not demonstrated a survival benefit. Current research efforts focus on the integration of novel systemic agents that exploit tumor-specific driver mutations, augment antitumor immune response, or enhance radiation sensitivity...
February 2017: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/27910502/filterscope-diagnostic-system-on-the-experimental-advanced-superconducting-tokamak-east
#5
Z Xu, Z W Wu, W Gao, Y J Chen, C R Wu, L Zhang, J Huang, J F Chang, X J Yao, W Gao, P F Zhang, Z Jin, Y M Hou, H Y Guo
A filterscope diagnostic system has been mounted to observe the line emission and visible bremsstrahlung emission from plasma on the experimental advanced superconducting tokamak during the 2014 campaign. By this diagnostic system, multiple wavelengths including Dα (656.1 nm), Dγ (433.9 nm), He ii (468.5 nm), Li i (670.8 nm), Li ii (548.3 nm), C iii (465.0 nm), O ii (441.5 nm), Mo i (386.4 nm), W i (400.9 nm), and visible bremsstrahlung radiation (538.0 nm) are monitored with corresponding wavelength filters...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910411/design-and-characterization-of-a-prototype-divertor-viewing-infrared-video-bolometer-for-nstx-u
#6
G G van Eden, M L Reinke, B J Peterson, T K Gray, L F Delgado-Aparicio, M A Jaworski, J Lore, K Mukai, R Sano, S N Pandya, T W Morgan
The InfraRed Video Bolometer (IRVB) is a powerful tool to measure radiated power in magnetically confined plasmas due to its ability to obtain 2D images of plasma emission using a technique that is compatible with the fusion nuclear environment. A prototype IRVB has been developed and installed on NSTX-U to view the lower divertor. The IRVB is a pinhole camera which images radiation from the plasma onto a 2.5 μm thick, 9 × 7 cm(2) Pt foil and monitors the resulting spatio-temporal temperature evolution using an IR camera...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910347/electron-density-profile-measurements-from-hydrogen-line-intensity-ratio-method-in-versatile-experiment-spherical-torus
#7
YooSung Kim, Yue-Jiang Shi, Jeong-Hun Yang, SeongCheol Kim, Young-Gi Kim, Jeong-Jeung Dang, Seongmoo Yang, Jungmin Jo, Soo-Ghee Oh, Kyoung-Jae Chung, Y S Hwang
Electron density profiles of versatile experiment spherical torus plasmas are measured by using a hydrogen line intensity ratio method. A fast-frame visible camera with appropriate bandpass filters is used to detect images of Balmer line intensities. The unique optical system makes it possible to take images of Hα and Hβ radiation simultaneously, with only one camera. The frame rate is 1000 fps and the spatial resolution of the system is about 0.5 cm. One-dimensional local emissivity profiles have been obtained from the toroidal line of sight with viewing dumps...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908252/the-combination-of-new-immunotherapy-and-radiotherapy-a-new-potential-treatment-for-locally-advanced-non-small-cell-lung-cancer
#8
Paola Claudia Sacco, Paolo Maione, Cesare Guida, Cesare Gridelli
Lung cancer is the main reason of cancer death worldwide. About 30% of non-small-cell lung cancer (NSCLC) cases are diagnosed with locally advanced disease (stage III). This is a mixed population including patients who have far more extensive and bulky disease than others. Management of these patients continue to be a challenge; frequently, patients have both local recurrence and distant metastases in this stage and the prognosis is very poor with a 5-year overall survival estimated between 3% and 7% for inoperable disease...
December 1, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27908168/examining-credentialing-criteria-and-poor-performance-indicators-for-iroc-houston-s-anthropomorphic-head-and-neck-phantom
#9
Mallory E Carson, Andrea Molineu, Paige A Taylor, David S Followill, Francesco C Stingo, Stephen F Kry
PURPOSE: To analyze the most recent results of the Imaging and Radiation Oncology Core Houston Quality Assurance Center's (IROC-H) anthropomorphic head and neck (H&N) phantom to determine the nature of failing irradiations and the feasibility of altering credentialing criteria. METHODS: IROC-H's H&N phantom, used for intensity-modulated radiation therapy credentialing for National Cancer Institute-sponsored clinical trials, requires that an institution's treatment plan agrees within ±7% of measured thermoluminescent dosimeter (TLD) doses; it also requires that ≥85% of pixels pass ±4 mm distance to agreement (7%/4 mm gamma analysis for film)...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27903188/the-role-of-diffusion-tensor-imaging-tractography-for-gamma-knife-thalamotomy-planning
#10
João Gabriel Ribeiro Gomes, Alessandra Augusta Gorgulho, Amanda de Oliveira López, Crystian Wilian Chagas Saraiva, Lucas Petri Damiani, Anderson Martins Pássaro, João Victor Salvajoli, Ludmila de Oliveira Siqueira, Bernardo Peres Salvajoli, Antônio Afonso Ferreira De Salles
OBJECTIVE The role of tractography in Gamma Knife thalamotomy (GK-T) planning is still unclear. Pyramidal tractography might reduce the risk of radiation injury to the pyramidal tract and reduce motor complications. METHODS In this study, the ventralis intermedius nucleus (VIM) targets of 20 patients were bilaterally defined using Iplannet Stereotaxy Software, according to the anterior commissure-posterior commissure (AC-PC) line and considering the localization of the pyramidal tract. The 40 targets and tractography were transferred as objects to the GammaPlan Treatment Planning System (GP-TPS)...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27903179/gamma-knife-radiosurgery-for-brain-metastases-from-pulmonary-large-cell-neuroendocrine-carcinoma-a-japanese-multi-institutional-cooperative-study-jlgk1401
#11
Takuya Kawabe, Masaaki Yamamoto, Yasunori Sato, Shoji Yomo, Takeshi Kondoh, Osamu Nagano, Toru Serizawa, Takahiko Tsugawa, Hisayo Okamoto, Atsuya Akabane, Kazuyasu Aita, Manabu Sato, Hidefumi Jokura, Jun Kawagishi, Takashi Shuto, Hideya Kawai, Akihito Moriki, Hiroyuki Kenai, Yoshiyasu Iwai, Masazumi Gondo, Toshinori Hasegawa, Soichiro Yasuda, Yasuhiro Kikuchi, Yasushi Nagatomo, Shinya Watanabe, Naoya Hashimoto
OBJECTIVE In 1999, the World Health Organization categorized large cell neuroendocrine carcinoma (LCNEC) of the lung as a variant of large cell carcinoma, and LCNEC now accounts for 3% of all lung cancers. Although LCNEC is categorized among the non-small cell lung cancers, its biological behavior has recently been suggested to be very similar to that of a small cell pulmonary malignancy. The clinical outcome for patients with LCNEC is generally poor, and the optimal treatment for this malignancy has not yet been established...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27898173/an-update-on-larynx-cancer
#12
REVIEW
Conor E Steuer, Mark El-Deiry, Jason R Parks, Kristin A Higgins, Nabil F Saba
Answer questions and earn CME/CNE Laryngeal cancer remains one of the most common tumors of the respiratory tract. Fortunately, significant advancements have been made over the past decade in the treatment of laryngeal cancer. Although surgery has been the historical mainstay for localized disease and still is an integral part of treatment, nonsurgical options like radiation and systemic therapy have emerged as viable options. In addition, in the metastatic setting, novel agents are showing promise for this patient population...
November 29, 2016: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/27897235/stereotactic-body-radiation-therapy-induces-fast-tumor-control-and-symptom-relief-in-patients-with-iliac-lymph-node-metastasis
#13
Zhongqiu Wang, Jing Wang, Hongqing Zhuang, Ping Wang, Zhiyong Yuan
The CyberKnife is a robotic stereotactic body radiotherapy (SBRT) system which has shown promising results for many malignances with good efficacy and low toxicity. This study aims to evaluate the response and local control (LC) obtained with CyberKnife in the management of iliac lymph node metastases (ILNM). Twenty-two patients with 27 ILNM were treated by CyberKnife from May 2010 to May 2016. Median follow-up time was 33 months (8-97). The complete response, partial response, stable disease and progression disease rates were 37...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895964/half-fan-based-intensity-weighted-region-of-interest-imaging-for-low-dose-cone-beam-ct-in-image-guided-radiation-therapy
#14
Boyeol Yoo, Kihong Son, Rizza Pua, Jinsung Kim, Alexander Solodov, Seungryong Cho
OBJECTIVES: With the increased use of computed tomography (CT) in clinics, dose reduction is the most important feature people seek when considering new CT techniques or applications. We developed an intensity-weighted region-of-interest (IWROI) imaging method in an exact half-fan geometry to reduce the imaging radiation dose to patients in cone-beam CT (CBCT) for image-guided radiation therapy (IGRT). While dose reduction is highly desirable, preserving the high-quality images of the ROI is also important for target localization in IGRT...
October 2016: Healthcare Informatics Research
https://www.readbyqxmd.com/read/27890801/eus-guided-paclitaxel-injection-as-an-adjunctive-therapy-to-systemic-chemotherapy-and-concurrent-external-beam-radiation-before-surgery-for-localized-or-locoregional-esophageal-cancer-a-multicenter-prospective-randomized-trial
#15
John M DeWitt, S Krishna Murthy, Ramesh Ardhanari, G Aaron DuVall, Grzegorz Wallner, Paul Litka, Claire Daugherty, Kirk Fowers
BACKGROUND AND AIMS: OncoGel is paclitaxel (PTX) formulated in a thermosensitive, biodegradable copolymer for focused cytotoxicity and radiosensitization. A phase IIa study suggested EUS-guided PTX injection into esophageal tumors subsequently receiving radiation therapy (RT) was safe. METHODS: In an international multicenter, prospective randomized phase IIb study, patients with local or locoregional adenocarcinoma or squamous cell carcinoma (SCCA) of the esophagus/GE junction and eligible for neoadjuvant chemoradiotherapy (CRT) before surgery were randomized to standard of care (SOC) plus EUS-guided PTX injection or SOC alone...
November 24, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27889595/is-there-a-role-for-salvage-radiotherapy-in-locally-advanced-breast-cancer-refractory-to-neoadjuvant-chemotherapy
#16
R C Coelho, F M L Da Silva, I M L Do Carmo, B V Bonaccorsi, S M Hahn, L D Faroni
INTRODUCTION: Locally advanced breast cancer (LABC) is a major problem, especially in developing countries. The standard treatment for LABC is neoadjuvant chemotherapy, with or without anti-Her2 therapy, followed by surgery, radiotherapy, and adjuvant systemic treatment if appropriate. However, there are few data in the literature addressing alternatives when neoadjuvant chemotherapy fails to reduce the tumour for surgery. MATERIALS AND METHODS: We conducted a retrospective study including all patients who had non-metastatic LABC treated with neoadjuvant chemotherapy and who were not eligible for surgical resection; these patients were submitted to salvage radiotherapy (RTX) between January 2000 and December 2012 at the Brazilian National Cancer Institute...
November 24, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27886554/a-biomaterial-assisted-mesenchymal-stromal-cell-therapy-alleviates-colonic-radiation-induced-damage
#17
Lara Moussa, Girish Pattappa, Bastien Doix, Sarra-Louiza Benselama, Christelle Demarquay, Marc Benderitter, Alexandra Sémont, Radia Tamarat, Jérôme Guicheux, Pierre Weiss, Gildas Réthoré, Noëlle Mathieu
Healthy tissues surrounding abdomino-pelvic tumours can be impaired by radiotherapy, leading to chronic gastrointestinal complications with substantial mortality. Adipose-derived Mesenchymal Stromal Cells (Ad-MSCs) represent a promising strategy to reduce intestinal lesions. However, systemic administration of Ad-MSCs results in low cell engraftment within the injured tissue. Biomaterials, able to encapsulate and withstand Ad-MSCs, can overcome these limitations. A silanized hydroxypropylmethyl cellulose (Si-HPMC) hydrogel has been designed and characterized for injectable cell delivery using the operative catheter of a colonoscope...
November 16, 2016: Biomaterials
https://www.readbyqxmd.com/read/27886180/microrna-regulation-of-endothelial-trex1-reprograms-the-tumour-microenvironment
#18
RaeAnna Wilson, Cristina Espinosa-Diez, Nathan Kanner, Namita Chatterjee, Rebecca Ruhl, Christina Hipfinger, Sunil J Advani, Jie Li, Omar F Khan, Aleksandra Franovic, Sara M Weis, Sushil Kumar, Lisa M Coussens, Daniel G Anderson, Clark C Chen, David A Cheresh, Sudarshan Anand
Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we report a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death. Using gain-and-loss of function approaches, we show that miR-103 exacerbates DNA damage and inhibits angiogenesis in vitro and in vivo. Local, systemic or vascular-targeted delivery of miR-103 in tumour-bearing mice decreased angiogenesis and tumour growth...
November 25, 2016: Nature Communications
https://www.readbyqxmd.com/read/27881158/evaluation-of-daily-patient-positioning-for-radiotherapy-with-a-commercial-3d-surface-imaging-system-catalyst%C3%A2
#19
F Walter, P Freislederer, C Belka, C Heinz, M Söhn, F Roeder
BACKGROUND: To report our initial clinical experience with the novel surface imaging system Catalyst™ (C-RAD AB, Sweden) in connection with an Elekta Synergy linear accelerator for daily patient positioning in patients undergoing radiation therapy. METHODS: We retrospectively analyzed the patient positioning of 154 fractions in 25 patients applied to thoracic, abdominal, and pelvic body regions. Patients were routinely positioned based on skin marks, shifted to the calculated isocenter position and treated after correction via cone beam CT which served as gold standard...
November 24, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27880736/experimental-validation-of-a-multi-energy-x-ray-adapted-scatter-separation-method
#20
A Sossin, V Rebuffel, J Tabary, J M Létang, N Freud, L Verger
Both in radiography and computed tomography (CT), recently emerged energy-resolved x-ray photon counting detectors enable the identification and quantification of individual materials comprising the inspected object. However, the approaches used for these operations require highly accurate x-ray images. The accuracy of the images is severely compromised by the presence of scattered radiation, which leads to a loss of spatial contrast and, more importantly, a bias in radiographic material imaging and artefacts in CT...
December 21, 2016: Physics in Medicine and Biology
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