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Keywords (Irradiation or radiation or r...

(Irradiation or radiation or radiotherapy) and immune

https://read.qxmd.com/read/38534959/outcomes-of-patients-with-non-small-cell-lung-cancer-and-brain-metastases-treated-with-the-upfront-single-agent-pembrolizumab-a-retrospective-and-multicentric-study-of-the-esckeyp-gfpc-cohort
#1
MULTICENTER STUDY
Simon Nannini, Florian Guisier, Hubert Curcio, Charles Ricordel, Pierre Demontrond, Safa Abdallahoui, Seyyid Baloglu, Laurent Greillier, Christos Chouaid, Roland Schott
Non-small cell lung cancer (NSCLC) is the most common cause of brain metastasis (BM). Little is known about immune checkpoint inhibitor activity in the central nervous system, especially in patients receiving monotherapy for tumors with a tumor proportion score (TPS) ≥ 50%. This noninterventional, retrospective, multicenter study, conducted with the GFPC, included treatment-naïve patients strongly positive for PD-L1 (TPS ≥ 50%) with BM receiving first-line single-agent pembrolizumab treatment between May 2017 and November 2019...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38534035/adverse-jaw-outcomes-from-immune-checkpoint-inhibitors-for-head-and-neck-cancer-case-reports
#2
JOURNAL ARTICLE
Gayathri Subramanian, Vincent Yeung, Soly Baredes, Sung Kim, Tessa Bergsbaken, Samuel Quek
Radiation treatment plays a mainstream role in the management of head and neck squamous cell carcinomas (HNSCCs). Adverse effects from radiation therapy include osteoradionecrosis of the jaw, and rarely, pathologic fracture. Immune checkpoint inhibitors (ICI) such as pembrolizumab are of growing relevance to the management of metastatic and recurrent HNSCCs. Adverse impacts on bone secondary to medications such as pembrolizumab and nivolumab have been sporadically documented in the literature. The objective of this manuscript is to raise awareness of possible increase in risk for adverse jaw outcomes in patients with HNSCCs exposed to both radiation treatment to the jaws and ICI therapy...
March 27, 2024: Quintessence International
https://read.qxmd.com/read/38533510/redefining-the-battle-against-colorectal-cancer-a-comprehensive-review-of-emerging-immunotherapies-and-their-clinical-efficacy
#3
REVIEW
Salima Shebbo, Najat Binothman, Manar Darwaish, Hanan A Niaz, Rwaa H Abdulal, Jamilah Borjac, Anwar M Hashem, Ahmad Bakur Mahmoud
Colorectal cancer (CRC) is the third most common cancer globally and presents a significant challenge owing to its high mortality rate and the limitations of traditional treatment options such as surgery, radiotherapy, and chemotherapy. While these treatments are foundational, they are often poorly effective owing to tumor resistance. Immunotherapy is a groundbreaking alternative that has recently emerged and offers new hope for success by exploiting the body's own immune system. This article aims to provide an extensive review of clinical trials evaluating the efficacy of various immunotherapies, including CRC vaccines, chimeric antigen receptor T-cell therapies, and immune checkpoint inhibitors...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533032/metal-ion-stimulation-related-gene-signatures-correlate-with-clinical-and-immunologic-characteristics-of-glioma
#4
JOURNAL ARTICLE
Chengzhi Jiang, Binbin Zhang, Wenjuan Jiang, Pengtao Liu, Yujia Kong, Jianhua Zhang, Wenjie Teng
BACKGROUND: Environmental factors serve as one of the important pathogenic factors for gliomas. Yet people focus only on the effect of electromagnetic radiation on its pathogenicity, while metals in the environment are neglected. This study aimed to investigate the relationship between metal ion stimulation and the clinical characteristics and immune status of GM patients. METHODS: Firstly, mRNA expression profiles of GM patients and normal subjects were obtained from Chinese GM Genome Atlas (CGGA) and Gene Expression Omnibus (GEO) to identify differentially expressed metal ion stimulation-related genes(DEMISGs)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532884/0-263-terahertz-irradiation-induced-genes-expression-changes-in-caenorhabditis-elegans
#5
JOURNAL ARTICLE
Sen Shang, Fei Gao, Qi Zhang, Tao Song, Wei Wang, Diwei Liu, Yubin Gong, Xiaoyun Lu
The biosafety of terahertz (THz) waves has emerged as a new area of concern with the gradual application of terahertz radiation. Even though many studies have been conducted to investigate the influence of THz radiation on living organisms, the biological effects of terahertz waves have not yet been fully revealed. In this study, Caenorhabditis elegans ( C. elegans ) was used to evaluate the biological consequences of whole-body exposure to 0.263 THz irradiation. The integration of transcriptome sequencing and behavioral tests of C...
April 19, 2024: IScience
https://read.qxmd.com/read/38531422/h2-antihistamines-may-be-useful-for-combination-therapies-in-cancer
#6
REVIEW
Nora A Mohamad, Tamara E Galarza, Gabriela A Martín
Cancer morbimortality is still a great concern despite advances in research and therapies. Histamine and its receptors' ligands can modulate different biological responses according to the cell type and the receptor subtype involved. Besides the wide variety of histamine functions in normal tissues, diverse roles in the acquisition of hallmarks of cancer such as sustained proliferative signaling, resistance to cell death, angiogenesis, metastasis, altered immunity and modified microenvironment have been described...
March 24, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38531102/implementation-of-a-randomized-placebo-controlled-trial-of-live-attenuated-malaria-sporozoite-vaccines-in-an-indonesian-military-study-population
#7
JOURNAL ARTICLE
Khoriah Indrihutami, Krisin Chand, Rizka Fahmia, Mutia Rahardjani, Fitria Wulandari, Decy Subekti, Rintis Noviyanti, Amin Soebandrio, Noch T Mallisa, I Made Mardika, Waras Budiman, Irwan Suriswan, Yogi Ertanto, Mei-Chun Chen, Tooba Murshedkar, Yonas Abebe, B Kim Lee Sim, Stephen L Hoffman, Thomas L Richie, Sky Chen, Iqbal R F Elyazar, Lenny L Ekawati, J Kevin Baird, Erni J Nelwan
Malaria eradication efforts prioritize safe and efficient vaccination strategies, although none with high-level efficacy against malaria infection are yet available. Among several vaccine candidates, Sanaria® PfSPZ Vaccine and Sanaria PfSPZ-CVac are, respectively, live radiation- and chemo-attenuated sporozoite vaccines designed to prevent infection with Plasmodium falciparum, the leading cause of malaria-related morbidity and mortality. We are conducting a randomized normal saline placebo-controlled trial called IDSPZV1 that will analyze the safety, tolerability, immunogenicity, and efficacy of PfSPZ Vaccine and PfSPZ-CVac administered pre-deployment to malaria-naive Indonesian soldiers assigned to temporary duties in a high malaria transmission area...
March 26, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38528555/formononetin-reverses-treg-th17-imbalance-in-immune-mediated-bone-marrow-failure-mice-by-regulating-the-pi3k-akt-signaling-pathway
#8
JOURNAL ARTICLE
Huixuan Lan, Wei Qiu, Jie Wu, Zhijing Hu, Xiaomin Zhang, Lingling Zhu
BACKGROUND: Severe aplastic anemia (SAA) is a syndrome of bone marrow failure which is life-threatening. Recent studies have demonstrated that CD4 + T cell subsets, including T regulatory (Treg) and T helper 17 (Th17) cells, play a pivotal role in the pathogenesis of SAA. Formononetin (FMN) is a natural compound extracted from the traditional Chinese medicine Huangqi, which has the ability to regulate the imbalance of Treg/Th17 cells in some inflammatory diseases. Nevertheless, the therapeutic effect of FMN in SAA has yet to be definitively established...
March 25, 2024: Chinese Medicine
https://read.qxmd.com/read/38527557/dual-targeting-of-tigit-and-pd-1-with-a-novel-small-molecule-for-cancer-immunotherapy
#9
JOURNAL ARTICLE
Yang Li, Beibei Li, Qingchao Wang, Xiangrui Zhang, Qiongqiong Zhang, Xiuman Zhou, Ranran Shi, Yahong Wu, Wenjie Zhai, Zhenzhen Chen, Xiaowen Zhou, Wenshan Zhao
Immune checkpoint inhibitors have unveiled promising clinical prospects in cancer treatment. Nonetheless, their effectiveness remains restricted, marked by consistently low response rates and affecting only a subset of patients. The co-blockade of TIGIT with PD-1 has exhibited substantial anti-tumor effects. Notably, there is a dearth of reports on small-molecule inhibitors concurrently targeting both TIGIT and PD-1. In this study, we employed Microscale Thermophoresis (MST) to screen our laboratory's existing repository of small molecules...
March 23, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38526757/utility-of-molecular-markers-in-predicting-local-control-specific-to-lung-cancer-spine-metastases-treated-with-stereotactic-body-radiotherapy
#10
JOURNAL ARTICLE
Dana Shor, Alexander V Louie, Kang Liang Zeng, Ines B Menjak, Eshetu G Atenafu, Chia-Lin Tseng, Jay Detsky, Jeremie Larouche, Beibei Zhang, Hany Soliman, Sten Myrehaug, Pejman Maralani, David M Hwang, Arjun Sahgal, Hanbo Chen
BACKGROUND AND PURPOSE: We report outcomes following spine stereotactic body radiotherapy (SBRT) in metastatic non-small cell lung cancer (NSCLC) and the significance of programmed death-ligand 1 (PD-L1) status, epidermal growth factor receptor (EGFR) mutation and timing of immune check point inhibitors (ICI) on local failure (LF). MATERIALS AND METHODS: 165 patients and 389 spinal segments were retrospectively reviewed from 2009 to 2021. Baseline patient characteristics, treatment and outcomes were abstracted...
March 25, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38525374/extensive-stage-small-cell-lung-cancer-with-cystic-brain-metastases-a-report-of-two-cases
#11
Fei Cai, Di Wu, Junling Liu, Shuxi Song, Jingyu Li, Zhendong Zheng, Long Xu
OBJECTIVE: Cystic brain metastases (BMs) are rare in small cell lung cancer (SCLC), and there are limited data on the treatment and prognosis of cystic BMs. Whole brain radiotherapy has been the mainstay for BMs since several years. Immune checkpoint inhibitors in extensive stage small cell lung cancer (ES-SCLC) have been shown to be suitable for patients who experienced better overall survival and progress-free survival and have been approved as the first-line treatment for ES-SCLC. In this report, we described two ES-SCLC patients developed cystic BMs after immunotherapy, after which the patients continued to treat the primary lesion with immune checkpoint inhibitors and the cystic BMs with radiotherapy...
2024: Cancer Management and Research
https://read.qxmd.com/read/38525327/mri-guided-photothermal-photodynamic-immune-activation-combined-with-pd-1-inhibitor-for-the-multimodal-combination-therapy-of-melanoma-and-metastases
#12
JOURNAL ARTICLE
Changqiang Wu, Wei Chen, Shuang Yan, Jie Zhong, Liang Du, Chenwu Yang, Yu Pu, Yang Li, Jiafu Lin, Mei Zeng, Xiaoming Zhang
Non-invasive image-guided precise photothermal/photodynamic therapy (PTT/PDT) has been proven to be an effective local treatment modality but incompetent against metastases. Hence, the combination of local PTT/PDT and systemic immunotherapy would be a promising strategy for tumor eradication. Herein, a magnetic resonance imaging (MRI)-visualized PTT/PDT agent (SIDP NMs) was constructed, and the efficacy of its multimodal combination with a programmed cell death 1 (PD-1) inhibitor in the treatment of melanoma and metastases was studied...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38525013/nano-drug-delivery-systems-targeting-cafs-a-promising-treatment-for-pancreatic-cancer
#13
REVIEW
Mingjie Wang, Wenxiang Xue, Hanghang Yuan, Zhicheng Wang, Lei Yu
Currently, pancreatic cancer (PC) is one of the most lethal malignant tumors. PC is typically diagnosed at a late stage, exhibits a poor response to conventional treatment, and has a bleak prognosis. Unfortunately, PC's survival rate has not significantly improved since the 1960s. Cancer-associated fibroblasts (CAFs) are a key component of the pancreatic tumor microenvironment (TME). They play a vital role in maintaining the extracellular matrix and facilitating the intricate communication between cancer cells and infiltrated immune cells...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38524643/multidisciplinary-treatment-for-small-cell-carcinoma-of-the-bladder-a-case-report
#14
JOURNAL ARTICLE
Yoshie Mita, Jun Teishima, Akihisa Yao, Riku Uematsu, Takahiko Yoshii, Takuto Hara, Masato Fujisawa, Ichiro Nakamura
Small cell carcinoma (SCC) of the urinary bladder is a rare and highly aggressive subtype of bladder cancer. Most cases are diagnosed at advanced stages, and its therapeutic strategy remains unestablished. Here, we report a case of bladder SCC in which multidisciplinary treatment has resulted in relatively long-term survival. A 68-year-old man presented with gross hematuria. A cystoscopy revealed an invasive bladder tumor. A transurethral resection of bladder tumor (TURBT) was performed, and the pathological diagnosis was SCC...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524525/extended-survival-with-metastatic-pancreatic-cancer-under-fruquintinib-treatment-after-failed-chemotherapy-two-case-reports
#15
Dan Wu, Qiong Wang, Shuai Yan, Xia Sun, Ya Qin, Ming Yuan, Nan-Yao Wang, Xian-Ting Huang
BACKGROUND: Pancreatic cancer is a highly malignant disease. After decades of treatment progress, the current five-year survival rate for patients is still less than 10%. For later-line treatment, the treatment options are even more limited. Anti-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic cancer. Preclinical data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis, improving the abnormal vascular structure, and modulating the tumour immune microenvironment...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38524389/post-thymectomy-autoimmune-flare-up-with-new-onset-type-1-diabetes-mellitus
#16
Tareq Al-Bkoor, Fateen Ata, Ammara Bint I Bilal, Mohammed Abdulgayoom, Honar Cherif, Haval Surchi
The thymus gland aids in the maturation of the immune system. An overactive or malfunctioning thymus gland, as seen in thymomas, can lead to disrupted immune systems. Thymectomy, the usual treatment, can paradoxically lead to further derangements in the immune system, leading to new autoimmune disorders. Most of these reported disorders are rheumatological. Except preclinical studies, there are no reported cases of autoimmune diabetes post-thymectomy. A 25-year-old woman who had malignant thymoma underwent chemotherapy, followed by thymectomy and radiotherapy...
March 2024: JCEM Case Rep
https://read.qxmd.com/read/38524139/progression-of-notch-signaling-regulation-of-b-cells-under-radiation-exposure
#17
REVIEW
Xin Shu, Jie Wang, Huihong Zeng, Lijian Shao
With the continuous development of nuclear technology, the radiation exposure caused by radiation therapy is a serious health hazard. It is of great significance to further develop effective radiation countermeasures. B cells easily succumb to irradiation exposure along with immunosuppressive response. The approach to ameliorate radiation-induced B cell damage is rarely studied, implying that the underlying mechanisms of B cell damage after exposure are eager to be revealed. Recent studies suggest that Notch signaling plays an important role in B cell-mediated immune response...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38524124/neoadjuvant-therapy-with-chemotherapy-and-immune-checkpoint-inhibitor-for-laryngeal-function-preservation-in-locally-advanced-hypopharyngeal-cancer
#18
JOURNAL ARTICLE
San-Gang Wu, Run-Jie Wang, Yi Zhou, Xian-Yang Luo
PURPOSE: To evaluate the efficacy and laryngeal function preservation of neoadjuvant treatment with chemotherapy and immune checkpoint inhibitor for locally advanced hypopharyngeal cancer (LAHPC). METHODS: We retrospectively collected LAHPC patients who were diagnosed between February 2022 and June 2023. The patients received a combination of chemotherapy and immune checkpoint inhibitors as the neoadjuvant therapy. The response to treatment, laryngeal function preservation rate, and short-term survival were assessed...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523939/granulocyte-macrophage-colony-stimulating-factor-in-combination-with-chemoradiation-for-recurrent-or-metastatic-cervical-cancer
#19
Na Zhang, Ming-Fang Guo
Recurrent or metastatic cervical cancer carries a bleak prognosis and presents a formidable challenge in terms of treatment. Granulocyte-macrophage colony-stimulating factor (GM-CSF) increases the body's immune response by enhancing antigen presentation, which has been rarely reported in recurrent or metastatic cervical cancer. A 44-year-old woman presented to the hospital with vaginal bleeding four years after radical hysterectomy for stage IB2 squamous cell carcinoma (SCC) of the cervix (grade II-III)...
February 2024: Curēus
https://read.qxmd.com/read/38522774/targeting-tumor-intrinsic-slc16a3-to-enhance-anti-pd-1-efficacy-via-tumor-immune-microenvironment-reprogramming
#20
JOURNAL ARTICLE
Ting Yu, Zhaoyun Liu, Qingxu Tao, Xin Xu, Xinyang Li, Yang Li, Minxin Chen, Rufei Liu, Dawei Chen, Meng Wu, Jinming Yu
Immunotherapy, especially immune checkpoint inhibitors, has revolutionized clinical practice within the last decade. However, primary and secondary resistance to immunotherapy is common in patients with diverse types of cancer. It is well-acknowledged that tumor cells can facilitate the formation of immunosuppressive microenvironments via metabolism reprogramming, and lactic acid, the metabolite of glycolysis, is a significant contributor. SLC16A3 (also named as MCT4) is a transporter mediating lactic acid efflux...
March 22, 2024: Cancer Letters
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