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Pregnancy complications

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https://www.readbyqxmd.com/read/29045485/alterations-in-the-placental-methylome-with-maternal-obesity-and-evidence-for-metabolic-regulation
#1
Kohzoh Mitsuya, Ashley N Parker, Lu Liu, Jianhua Ruan, Margreet C M Vissers, Leslie Myatt
The inflammatory and metabolic derangements of obesity in pregnant women generate an adverse intrauterine environment, increase pregnancy complications and adverse fetal outcomes and program the fetus for obesity and metabolic syndrome in later life. We hypothesized that epigenetic modifications in placenta including altered DNA methylation/hydroxymethylation may mediate these effects. Term placental villous tissue was collected following cesarean section from lean (prepregnancy BMI<25) or obese (BMI>30) women...
2017: PloS One
https://www.readbyqxmd.com/read/29045342/hypertensive-disorders-of-pregnancy-and-postpartum-readmission-in-the-united-states-national-surveillance-of-the-revolving-door
#2
Mulubrhan F Mogos, Jason L Salemi, Kiara K Spooner, Barbara L McFarlin, Hamisu H Salihu
OBJECTIVES: Hypertensive disorders of pregnancy (HDP) represent the most common cause of maternal-fetal morbidity and mortality. Yet, the prevalence and cost of postpartum (42-day) readmission (PPR) among HDP-complicated pregnancies in the United States remains unknown. This study provides national prevalence and cost estimates of HDP, and examine factors associated with potentially preventable PPR following HDP-complicated pregnancies. METHOD: The 2013 and 2014 Nationwide Readmissions Databases were used to investigate HDP and PPR among delivery hospitalizations to women aged 15-49 years...
October 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29044597/short-and-long-term-complications-of-in-utero-exposure-to-lamotrigine
#3
Merav Cohen-Israel, Itai Berger, Einat Y Martonovich, Gil Klinger, Bracha Stahl, Nehama Linder
AIM: The present study evaluates the effect of antenatal lamotrigine exposure, on short and long term pediatric outcome. METHODS: The study included the children of 83 epileptic women treated with lamotrigine during pregnancy, at a tertiary medical center between 2004-2014. All newborns were monitored for vital signs, congenital malformations and Finnegan score. In addition, the parents completed a questionnaire regarding child's development and health up to the age of 12 years...
October 18, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29044348/sonographically-abnormal-placenta-an-association-with-an-increased-risk-poor-pregnancy-outcomes
#4
W D Wan Masliza, M Y Bajuri, M R Hassan, N M Naim, A Shuhaila, S Das
BACKGROUND: The placenta is a most interesting but unfortunately often ignored and misunderstood organ. Placental abnormalities, therefore, can be an "early warning system" for fetal problems. A complete prenatal sonographic examination of the placenta is an essential component as its abnormalities can have a direct effect on fetal or maternal outcomes, obstetrical management and future fertility. OBJECTIVE: To determine whether any association exists between the finding of an increased thickness of placenta, abnormal placenta shape, placental calcification, placental lake and abnormal cord insertion site at 20-22 and 30-32 weeks gestation with an increased risk of uteroplacental complications or a poor pregnancy outcome...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29043829/postpartum-acute-hemolytic-transfusion-reactions-associated-with-anti-lea-in-two-pregnancies-complicated-by-preeclampsia
#5
Marcia Marchese
Lewis blood group antibodies, which are mostly naturally occurring and considered clinically insignificant, have rarely been documented as a cause of acute hemolytic transfusion reactions (AHTRs). This report presents two cases of AHTRs caused by anti-Lea occurring in postpartum black females (one group B, one group AB) whose pregnancies were complicated by preeclampsia. Neither anti-Lea was detected by automated solid-phase red cell adherence technology in pre-transfusion testing. Therefore, red blood cell units, compatible by electronic crossmatch, were issued and transfused...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29043280/prediction-of-adequate-prenatal-care-utilization-based-on-the-extended-parallel-process-model
#6
Sepideh Hajian, Fatemeh Imani, Hedyeh Riazi, Fatemeh Salmani
BACKGROUND: Pregnancy complications are one of the major public health concerns. One of the main causes of preventable complications is the absence of or inadequate provision of prenatal care. The present study was conducted to investigate whether Extended Parallel Process Model's constructs can predict the utilization of prenatal care services. METHODS: The present longitudinal prospective study was conducted on 192 pregnant women selected through the multi-stage sampling of health facilities in Qeshm, Hormozgan province, from April to June 2015...
October 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29041829/characteristics-and-outcome-of-severe-preeclampsia-eclampsia-concurrent-with-or-complicated-by-acute-pancreatitis-a-report-of-five-cases-and-literature-review
#7
Cuiqin Sang, Shuzhen Wang, Zhenyu Zhang, Junli Lu
OBJECTIVE: The objective of this study is to determine the rate of acute pancreatitis in preeclampsia/eclampsia patients and describe the clinical manifestations, treatment characteristics and outcome of five cases of severe preeclampsia concurrent with or complicated by acute pancreatitis. METHODS: The clinical data of pregnant women with preexisting or gestational hypertension who sought medical care between January 2002 and December 2015 at the Pregnant Women Critical Care Unit of Chaoyang Hospital, Capital Medical University, Beijing, China were retrieved...
October 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29040571/patient-centered-early-pregnancy-care-a-systematic-review-of-quantitative-and-qualitative-studies-on-the-perspectives-of-women-and-their-partners
#8
M M J van den Berg, E A F Dancet, T Erlikh, F van der Veen, M Goddijn, P J Hajenius
BACKGROUND: Early pregnancy complications, defined as miscarriage, recurrent miscarriage or ectopic pregnancy, affect the physical and psychological well-being of intended parents. Research in this field so far has focused mainly on improving accuracy of diagnostic tests and safety and effectiveness of therapeutic management. An overview of aspects of care valued by women and/or their partners is missing. OBJECTIVE AND RATIONALE: This systematic review aims to provide an overview of aspects of care valued by women and/or their partners faced with early pregnancy complications and to identify potential targets for improvement in early pregnancy healthcare...
October 11, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29040540/new-debate-is-it-time-for-infertility-weight-loss-programmes-to-be-couple-based
#9
Damian Best, Alison Avenell, Siladitya Bhattacharya, Gertraud Stadler
With obesity on the rise in the general population, it has also become more prevalent among people of reproductive age. Weight loss has shown benefits in overweight women and men experiencing fertility problems. However, the existing weight-loss interventions for individuals with infertility are associated with high drop-out rates and limited success. In this article, we argue for the development of weight-loss programmes targeting couples, as couples are routinely seen in fertility clinics, rather than individuals...
October 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040334/advanced-maternal-age-and-adverse-pregnancy-outcomes-a-systematic-review-and-meta-analysis
#10
Samantha C Lean, Hayley Derricott, Rebecca L Jones, Alexander E P Heazell
BACKGROUND: Advanced maternal age (AMA; ≥35 years) is an increasing trend and is reported to be associated with various pregnancy complications. OBJECTIVE: To determine the risk of stillbirth and other adverse pregnancy outcomes in women of AMA. SEARCH STRATEGY: Embase, Medline (Ovid), Cochrane Database of Systematic Reviews, ClinicalTrials.gov, LILACS and conference proceedings were searched from ≥2000. SELECTION CRITERIA: Cohort and case-control studies reporting data on one or more co-primary outcomes (stillbirth or fetal growth restriction (FGR)) and/or secondary outcomes in mothers ≥35 years and <35 years...
2017: PloS One
https://www.readbyqxmd.com/read/29040004/building-bridges-a-case-for-community-health-worker-provision-of-misoprostol-only-abortion-in-the-first-trimester
#11
Claire Tebbets, Diana Santana, José Ros Silvestre, Dee Redwine
INTRODUCTION: The consequences of unsafe abortion are devastating to women, their families, and their communities. Medication abortion presents an important alternative to harmful self-induction practices and surgical intervention under questionable circumstances. In settings where mifepristone is unavailable, the use of misoprostol alone is a safe and effective option for terminating an unwanted pregnancy. Studies have demonstrated the safety and efficacy of administration of misoprostol by community health workers (CHW) for indications such as postpartum hemorrhage and treatment of incomplete abortion...
October 17, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29039130/aspirin-for-prevention-of-preeclampsia
#12
A Atallah, E Lecarpentier, F Goffinet, M Doret-Dion, P Gaucherand, V Tsatsaris
Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular complications. The indications for the use of aspirin during pregnancy are, however, the subject of much controversy. Since the first evidence of the obstetric efficacy of aspirin in 1985, numerous studies have tried to determine the effect of low-dose aspirin on the incidence of preeclampsia, with very controversial results. Large meta-analyses including individual patient data have demonstrated that aspirin is effective in preventing preeclampsia in high-risk patients, mainly those with a history of preeclampsia...
October 16, 2017: Drugs
https://www.readbyqxmd.com/read/29038040/hysteroscopic-intrauterine-adhesiolysis-using-a-blunt-spreading-dissection-technique-with-a-double-action-forceps
#13
Huan Huang, Chunxia Cheng, Grace Johnson, Ruoyi Wang, Min Xue, Aiqian Zhang, Dabao Xu, Xiaoming Guan
STUDY OBJECTIVE: To demonstrate step by step the technique of hysteroscopic adhesiolysis (HA) by means of a blunt spreading technique using double action forceps to dissect and restore the layer between the anterior and posterior uterine walls in a patient with severe intrauterine adhesions (IUA), particularly in cases in which the endometrial lining is obscured on ultrasound imaging and the endometrial cavity is completely occluded on hysteroscopy. DESIGN: Step-by-step explanation of the technique using videos and pictures (educative video) (Canadian Task Force Classification III)...
October 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29037563/management-of-pregnancy-in-pancreas-alone-transplant-recipient-complicated-with-stage-4-chronic-renal-insufficiency-and-superimposed-pre-eclampsia-case-report-and-literature-review
#14
Yung-Shih Lee, Mei-Yu Peng, Chin-Ru Ker, Te-Fu Chan
OBJECTIVE: With the prolonged life expectancy in solid organ transplant recipients, their quality of life and fertility desire become of particular concern. Pregnancy in pancreas-alone transplantation, although rare and complicated to manage, is not impossible anymore. We here report such a case with literature review to address this issue. CASE REPORT: A 29-year-old, primigravida patient with underlying stage 4 chronic renal insufficiency and type 1 diabetes mellitus post pancreas-alone transplantation 5 years prior to her initial visit consulted our service...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29037561/repeated-pregnancy-with-concomitant-presence-of-ovarian-teratoma-a-case-report-and-literature-review
#15
Liang-Hsuan Chen, Shuenn-Dhy Chang, Hong-Yuan Huang, Hsin-Shih Wang, Yung-Kuei Soong, Hsien-Ming Wu
OBJECTIVE: Benign mature teratoma during pregnancy is common, mostly discovered incidentally by antenatal sonography. However, repeated pregnancy coincident with ovarian mature teratoma is rarely reported. The cases of teratoma with rapid growing characteristics are even more unique. CASE REPORT: A 17-year-old woman was pregnant at 6 weeks of gestation with a left ovarian teratoma. She underwent artificial abortion followed by surgical removal of the teratoma. However, eleven years after the surgery, a right ovarian teratoma was found incidentally by antepartum sonography at 21 weeks of gestation...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29037549/long-term-outcome-of-pregnancy-complicating-with-severe-aplastic-anemia-under-supportive-care
#16
Kuan-Ju Chen, Yao-Lung Chang, Horng Chang, Shen-Yuan Su, Hsiu-Huei Peng, Shuenn-Dyh Chang, An-Shine Chao
OBJECTIVES: Pregnancy associated with aplastic anemia (AA) is a rare and heterogeneous disorder. We aimed to identify and evaluate the maternal and pregnant outcomes of pregnancy-associated severe AA treated with supportive care. MATERIALS AND METHODS: A 25-year retrospective study was conducted at in a single center between 1990 and 2014 with pregnancy associated severe AA. In addition, relevant published cases of antenatally diagnosed pregnancy-associated severe AA after 1990 were identified by PubMed...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29037482/a-low-angiogenic-index-1-plgf-svegfr-1-ratio-at-24-28-weeks-of-gestation-is-a-biomarker-to-identify-the-patient-at-risk-for-subsequent-fetal-death
#17
Tinnakorn Chaiworapongsa, Roberto Romero, Offer Erez, Adi L Tarca, Agustin Conde-Agudelo, Piya Chaemsaithong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Bo Hyun Yoon, Sonia S Hassan, Lami Yeo, Steven J Korzeniewski
OBJECTIVE: To determine if maternal plasma concentrations of angiogenic and anti-angiogenic factors measured at 24-28 weeks of gestation can predict subsequent fetal death. METHODS: A case-cohort study was designed to include 1000 randomly selected subjects and all remaining fetal deaths (cases) from a cohort of 4006 women with a singleton pregnancy, enrolled at 6-22 weeks of gestation, in a pregnancy biomarker cohort study. The placentas of all fetal deaths were histologically examined by pathologists who used a standardized protocol and were blinded to patient outcomes...
October 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29037097/obstetrical-and-neonatal-outcomes-of-pregnancies-complicated-by-endometriosis
#18
Anat Shmueli, Lina Salman, Liran Hiersch, Eran Ashwal, Eran Hadar, Arnon Wiznitzer, Yariv Yogev, Amir Aviram
OBJECTIVE: Endometriosis is defined as the presence of endometrial-like tissue outside the uterus, associated with pelvic pain and subfertility, affecting 0.6-10% of the general female population. The association between endometriosis and obstetrical outcomes is not well established. We aimed to evaluate whether endometriosis is associated with a higher incidence of obstetrical and neonatal complications. STUDY DESIGN: A retrospective cohort study of all deliveries in a university-affiliated tertiary hospital (2007-2014)...
October 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29035901/ce-preeclampsia-current-approaches-to-nursing-management
#19
Cindy M Anderson, Mandy J Schmella
A clinical review of risk factors, diagnostic criteria, and patient care. ABSTRACT: Preeclampsia, one of four hypertensive disorders of pregnancy, has traditionally been characterized as new-onset hypertension and proteinuria developing after 20 weeks' gestation. It is, however, now understood to be a complex, progressive, multisystem disorder with a highly variable presentation and a number of potentially life-threatening complications. The American College of Obstetricians and Gynecologists Task Force on Hypertension in Pregnancy has refined preeclampsia diagnostic criteria accordingly, and as the disorder's pathogenesis has been more clearly defined, new targets for screening, diagnosis, prevention, and treatment have emerged...
October 13, 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/29035838/effect-of-two-treatment-protocols-for-ketosis-on-the-resolution-postpartum-health-milk-yield-and-reproductive-outcomes-of-dairy-cows
#20
Jae-Kwan Jeong, In-Soo Choi, Sung-Ho Moon, Soo-Chan Lee, Hyun-Gu Kang, Young-Hun Jung, Soo-Bong Park, Ill-Hwa Kim
We determined the effect of ketosis treatment with propylene glycol (PG) or PG plus l-carnitine and methionine (Metabolase(®), Fatro, Bologna, Italy) on the resolution, postpartum health, milk yield, and reproductive performances of dairy cows. Blood from 475 Holstein cows was collected weekly until 4 weeks after calving to measure blood β-hydroxybutyrate (BHBA) concentrations. Cows with blood BHBA concentration ≥1.2 mmol/L were diagnosed with ketosis and were enrolled. One hundred and fifty cows diagnosed with ketosis were randomly assigned to three treatment groups (Day 0): (1) PG (300 g, PO) for 3 days (PG group, n = 50), (2) PG (300 g, PO) plus l-carnitine (1...
September 25, 2017: Theriogenology
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