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Pregnancy complications

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https://www.readbyqxmd.com/read/28544689/class-ii-obese-and-healthy-pregnant-controls-exhibit-indistinguishable-pro-and-anti-inflammatory-immune-responses-to-caesarian-section
#1
Caroline Graham, Mullein Thorleifson, William P Stefura, Duane J Funk, Kent T HayGlass
INTRODUCTION: Obesity during pregnancy is associated with meta-inflammation and an increased likelihood of clinical complications. Surgery results in intense, acute inflammatory responses in any individual. Because obese individuals exhibit constitutive inflammatory responses and high rates of Caesarian section, it is important to understand the impact of surgery in such populations. Whether more pronounced pro-inflammatory cytokine responses and/or counterbalancing changes in anti-inflammatory immune modulators occurs is unknown...
May 25, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28544499/preventing-progression-from-gestational-diabetes-mellitus-to-diabetes-a-thought-filled-review
#2
REVIEW
Michal Kasher-Meron, Martin M Grajower
Women with a history of gestational diabetes (GDM) are at high risk for developing type 2 diabetes mellitus (T2DM). In studies with long periods of follow up, diabetes incidence of up to 70% has been reported. The appropriate follow up of women following a pregnancy complicated by GDM has not been studied. Published guidelines recommend that obstetrician/gynecologists, who are often the de facto primary care physicians for these otherwise healthy young women, make glucose monitoring in the post-partum period part of their annual examinations...
May 19, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28543690/smokeless-tobacco-consumption-and-stillbirth-population-based-case-control-study-in-rural-bangladesh
#3
Mohammad Shakhawat Hossain, Kypros Kypri, Bayzidur Rahman, Abul Hasnat Milton
INTRODUCTION AND AIMS: To investigate the association between smokeless tobacco consumption (STC) during pregnancy and risk of stillbirth. DESIGN AND METHODS: We conducted a population-based case-control study of 253 cases and 759 randomly selected control women in Madaripur, Bangladesh. We conducted a survey of two rural local government areas, including 8082 women, and identified cases based on self-report of a stillbirth outcome of each participant's first pregnancy...
May 25, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28542791/pregnancy-outcomes-among-syrian-refugee-and-jordanian-women-a-comparative-study
#4
K Alnuaimi, M Kassab, R Ali, K Mohammad, K Shattnawi
AIM: To compare pregnancy outcomes of Syrian refugee women and Jordanian women. BACKGROUND AND INTRODUCTION: In the past few years, thousands of Syrians fled Syria to neighbouring countries such as Jordan as a result of the continuing conflict in their country. Pregnant refugee women are facing many difficulties that increase the prevalence of antenatal complications. However, there is limited awareness of whether Syrian refugee women have different risks of pregnancy outcomes than Jordanian women...
May 25, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28542650/interdependence-of-jak-stat-and-mapk-signaling-pathways-during-egf-mediated-htr-8-svneo-cell-invasion
#5
Ankita Malik, Rahul Pal, Satish Kumar Gupta
Invasion of trophoblast cells is spatio-temporally regulated by various cytokines and growth factors. In pregnancy, complications like preeclampsia, shallow invasion of trophoblast cells and low amounts of epidermal growth factor (EGF) have been reported. In the present study, regulatory mechanisms associated with EGF-mediated invasion in HTR-8/SVneo trophoblastic cells have been delineated. Treatment of HTR-8/SVneo cells with EGF (10 ng/ml) led to eight fold increase (p < 0.05) in invasion. Increased invasion of HTR-8/SVneo cells by EGF was associated with an increase in phosphorylation of ERK½...
2017: PloS One
https://www.readbyqxmd.com/read/28542561/impaired-functional-capacity-of-fetal-endothelial-cells-in-preeclampsia
#6
Lars Brodowski, Jennifer Burlakov, Sarah Hass, Constantin von Kaisenberg, Frauke von Versen-Höynck
OBJECTIVES: Preeclampsia is one of the main contributers to maternal and fetal morbidity and mortality during pregnancy. A history of preeclampsia puts mother and offspring at an increased cardiovascular risk in later life. We hypothesized that at the time of birth functional impairments of fetal endothelial cells can be detected in pregnancies complicated by preeclampsia and that a therapeutic intervention using 1,25 (OH)2 vitamin D3 can reverse the adverse effects of preeclampsia on cell function...
2017: PloS One
https://www.readbyqxmd.com/read/28542047/inferior-vena-cava-thrombus-in-a-postpartum-patient-with-fontan-physiology-a-case-report
#7
Jessica A Tashjian, Hannah Fraint, James DiNardo, Kathryn Rouine-Rapp
Women with complex congenital heart disease, such as those with single-ventricle physiology, are surviving into adulthood and becoming pregnant. Because of their complex physiology, common peripartum complications pose unique risks. We describe a patient with a single ventricle who underwent an external vascular conduit, nonfenestrated Fontan procedure in childhood and then presented during the postpartum period with extensive thrombosis in her lower extremity deep venous system and inferior vena cava. In this article, we will discuss single-ventricle physiology and the implications of pregnancy, anesthetic considerations, and data for maternal and fetal outcomes in this population...
May 23, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28540849/pre-eclampsia-overview-on-the-role-of-biomarkers-in-2016
#8
Henry Paridaens, Damien Gruson
Preeclampsia which affects approximatively 2% of pregnancies is a major cause of maternal and perinatal morbidity and mortality. Pathogenesis of pre-eclampsia is nowadays increasingly understood. It implies multiple actors and biomarkers appear to be playing a major role. New uses of those biomarkers for risk stratification and diagnosis of predisposed preeclamptic patients followed by obstetricians is an hot topic. The combined approach of biomarkers, medical history and obstetrical ultrasounds enables risk estimation in the first quarter and later on...
June 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28540575/the-yield-and-complications-of-amniocentesis-performed-after-24-weeks-of-gestation
#9
Keren Tzadikevitch Geffen, Ohad Ben-Zvi, Omer Weitzner, Amir Peleg, Tal Biron-Shental, Rivka Sukenik-Halevy
PURPOSE: This study assessed the use and complications of late amniocentesis (AC) and analyzed factors that affect complication rate. METHODS: A retrospective analysis of 167 genetic AC performed after 24 weeks during a 10-year period in two medical centers was conducted. Data regarding the indications for AC, genetic work-up, and pregnancy outcomes were retrieved from patient medical records and telephone-based questionnaires. RESULTS: Mean gestational age (GA) at the time of AC was 31...
May 24, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28540262/inactive-hepatitis-b-carrier-and-pregnancy-outcomes-a-systematic-review-and-meta-analysis
#10
REVIEW
Afsaneh Keramat, Masud Younesian, Mohammad Gholami Fesharaki, Maryam Hasani, Samaneh Mirzaei, Elham Ebrahimi, Seyed Moaed Alavian, Fatemeh Mohammadi
BACKGROUND: We aimed to explore whether maternal asymptomatic hepatitis B (HB) infection effects on pre-term rupture of membranous (PROM), stillbirth, preeclampsia, eclampsia, gestational hypertension, or antepartum hemorrhage. METHODS: We searched the PubMed, Scopus, and ISI web of science from 1990 to Feb 2015. In addition, electronic literature searches supplemented by searching the gray literature (e.g., conference abstracts thesis and the result of technical reports) and scanning the reference lists of included studies and relevant systematic reviews...
April 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28540049/outcome-of-misoprostol-and-oxytocin-in-induction-of-labour
#11
Trishna Acharya, Ramesh Devkota, Bimbishar Bhattarai, Radha Acharya
BACKGROUND: Induction of labour is the process of initiating the labour by artificial means from 24 weeks of gestation. The main aim of this study is to find out the maternal and foetal outcomes after induction of labour with misoprostol and oxytocin beyond 37 weeks of gestation. METHODS: This was a hospital-based observational study carried out at Paropakar Maternity and Women's Hospital, Nepal. Misoprostol of 25 µg was inserted in posterior fornix of vagina or oxytocin infusion was started from 2...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28539276/-expectant-therapy-versus-curettage-for-retained-products-of-conception-after-second-trimester-termination-of-pregnancy-analysis-of-outcomes-and-complications
#12
Wen-Juan Zeng, Sheng-Li An, Hao Huang, Qi-Tao Huang, Fei-Feng Li, Hai-Zhen Wang, Dan-Chun Cai, Yun-Fei Gao
OBJECTIVE: To evaluate the prognosis and complications of expectant therapy and curettage for retained product of conception (RPOC) after second trimester termination of pregnancy (TOP). METHODS: A total of 270 patients with RPOC following second trimester TOP in Nanfang Hospital between January, 2014 and December, 2015 were included in this study. The duration of vaginal bleeding time and menstruation recovery interval were compared between patients receiving expectant therapy and curettage for RPOC, and binary logistic regression was used to assess the risk factors for complications in bivariate and multivariate analyses...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28539207/effect-of-maternal-age-and-cardiac-disease-severity-on-outcome-of-pregnancy-in-women-with-congenital-heart-disease
#13
Eva Furenäs, Peter Eriksson, Ulla-Britt Wennerholm, Mikael Dellborg
BACKGROUND: There is an increasing prevalence of women with congenital heart defects reaching childbearing age. In western countries women tend to give birth at a higher age compared to some decades ago. We evaluated the CARdiac disease in PREGnancy (CARPREG) and modified World Health Organization (mWHO) risk classifications for cardiac complications during pregnancies in women with congenital heart defects and analyzed the impact of age on risk of obstetric and fetal outcome. METHODS: A single-center observational study of cardiac, obstetric, and neonatal complications with data from cardiac and obstetric records of pregnancies in women with congenital heart disease...
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28538012/antiphospholipid-syndrome-an-update-for-clinicians-and-scientists
#14
Andrew P Vreede, Paula L Bockenstedt, Jason S Knight
PURPOSE OF REVIEW: Antiphospholipid syndrome (APS) is a leading acquired cause of thrombosis and pregnancy loss. Upon diagnosis (which is unlikely to be made until at least one morbid event has occurred), anticoagulant medications are typically prescribed in an attempt to prevent future events. This approach is not uniformly effective and does not prevent associated autoimmune and inflammatory complications. The goal of this review is to update clinicians and scientists on mechanistic and clinically relevant studies from the past 18 months, which have especially focused on inflammatory aspects of APS pathophysiology...
May 22, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28537456/angiogenic-profile-and-smoking-in-the-finnish-genetics-of-pre-eclampsia-consortium-finnpec-cohort
#15
Tiina Jääskeläinen, Sanna Suomalainen-König, Esa Hämäläinen, Kari Pulkki, Jarkko Romppanen, Seppo Heinonen, Hannele Laivuori
Objectives The biological mechanism by which smoking reduces the risk of pre-eclampsia (PE) is unresolved. We studied serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and their ratio, in addition to soluble endoglin (sEng) in early and late pregnancy to ascertain whether these factors are altered in women who smoke. Subjects and Methods First trimester serum samples were available from 217 women who later developed PE and 238 women who did not develop PE. Second/third trimester serum samples were available from 174 PE and 54 non-PE women...
May 24, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28537347/adnexal-torsion-in-the-first-trimester-of-pregnancy-diagnosis-laparoscopic-management-and-review-of-the-literature
#16
Rafael Bras, Jorge Braga, António Tomé, Helder Ferreira
We report a case of an adnexal torsion in a 27-year-old woman in her 12th week of gestation. She presented with hypogastric and lumbar pain with biliary vomiting and nausea. Upon physical examination, tenderness in the right lower quadrant with rebound tenderness was apparent, and gynecological examination revealed right adnexal tenderness with absence of abnormal cervical discharge. The transvaginal ultrasonography demonstrated an enlarged cystic right ovary with no flow detected on color and power Doppler mode...
May 24, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28536980/a-retrospective-cohort-study-of-obstetric-outcomes-in-opioid-dependent-women-treated-with-implant-naltrexone-oral-methadone-or-sublingual-buprenorphine-and-non-dependent-controls
#17
Erin Kelty, Gary Hulse
BACKGROUND: Opioid pharmacotherapies play an important role in the treatment of opioid-dependent women; however, very little is known about the safety of naltrexone in pregnant patients. OBJECTIVE: This study examined the obstetric health of opioid-dependent women who were treated with implant naltrexone during pregnancy, and compared them with women treated with methadone and/or buprenorphine and a cohort of non-opioid-dependent controls. METHODS: Women treated with implant naltrexone, oral methadone or sublingual buprenorphine between 2001 and 2010, along with a cohort of age-matched controls, were linked with records from midwives, hospital and emergency departments (EDs) and the death registry to identify pregnancy and health events that occurred during pregnancy and in the post-partum period...
May 23, 2017: Drugs
https://www.readbyqxmd.com/read/28536812/maternal-ascites-an-independent-prognostic-factor-in-severe-preeclampsia-a-matched-cohort-study
#18
J Yavana Suriya, Anish Keepanasseril, K Manikandan, Dilip Kumar Maurya, P Veena, S Soundara Raghavan
BACKGROUND: Preeclampsia is a multi-systemic, multi-organ dysfunction associated with increased maternal and perinatal complications. The presence of maternal ascites, a manifestation of endothelial dysfunction and increased capillary permeability, is shown to be associated with adverse outcomes. We aim to investigate the impact of maternal ascites on pregnancy outcome in women with severe preeclampsia. METHODS: A matched cohort study was conducted in a tertiary care teaching hospital in South India between March 2014 and March 2015...
May 23, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28536761/-anticoagulation-direct-oral-anticoagulants
#19
B Kemkes-Matthes
Since direct oral anticoagulants (DOAC) have become available, use of anticoagulant treatment has become easier and safer-for patients suffering from thromboembolic diseases as well as for patients with atrial fibrillation: Because of constant bioavailability, fixed dose regimen treatment is possible, monitoring not necessary and severe bleeding complications-particularly intracranial hemorrhages-rare in comparison to vitamin K anticoagulants. To gain all these advantages, it is essential to give DOAC in the correct dosage...
May 23, 2017: Der Internist
https://www.readbyqxmd.com/read/28534997/reduced-expression-of-follicle-stimulating-hormone-receptor-mrna-and-protein-in-pregnancies-complicated-by-pre%C3%A2-eclampsia
#20
Mo Li, Yifan Jia, Yan Ling, Yilu Chen, Lu Zhang, Dan Luo, Lidan Lai, Meijun Guo, Dalei Zhang, Min Ren, Hong Xu, Haibin Kuang
Expression and function of the follicle‑stimulating hormone receptor (FSHR) are traditionally thought to be limited to the ovary in females. However, recent studies have indicated that the FSHR is also expressed in endothelial cells of the placental vasculature, and that the haploinsufficiency of the feto‑placental FSHR impaired the growth of the mouse placenta. The aim of the current study was to investigate the placental expression of FSH and FSHR in pregnancies complicated by pre‑eclampsia. Placental tissue samples were collected from 20 pregnancies with pre‑eclampsia and 25 normal pregnancies...
May 18, 2017: Molecular Medicine Reports
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