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Giant cell arteritis

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https://www.readbyqxmd.com/read/29685012/evaluating-the-utility-of-autoantibodies-for-disease-activity-and-relapse-in-giant-cell-arteritis
#1
T Kuret, K Lakota, A Hočevar, B Burja, S Čučnik, S Sodin-Semrl
In patients with giant cell arteritis (GCA), autoantibodies against cytoskeletal elements, cardiolipin, neutrophil cytoplasmic antigens, ferritin, endothelial and smooth muscle cells have been reported, however no updated reviews are available evaluating their clinical utility. Methodology of detection is important, especially for quantitative assays, e.g. enzyme-linked immunoassays and multiplex beadbased immunoassays, while semiquantitative assays contribute valuable data on isoforms, epitope mapping and cellular localization...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29680850/temporal-headache-and-jaw-claudication-may-be-the-key-for-the-diagnosis-of-giant-cell-arteritis
#2
B Peral-Cagigal, Á Perez-Villar, L-M Redondo-Gonzalez, C Garcia-Sierra, M Morante-Silva, B Madrigal-Rubiales, A Verrier-Hernandez
BACKGROUND: Temporal artery biopsy (TAB) is a surgical procedure with a low positive yield. The purpose of this study is to determine which variables are the most important in the giant cell arteritis (GCA) diagnosis. The objective of this evaluation is to improve the percentage of positive temporal artery biopsy and if possible, avoid the biopsy in some cases. MATERIAL AND METHODS: A retrospective clinical study consisted of 90 patients who had undergone TAB at the Rio Hortega Hospital (Spain) from January 2009 to December 2016...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29676602/tocilizumab-for-the-treatment-of-giant-cell-arteritis
#3
Michael Schirmer, Francesco Muratore, Carlo Salvarani
Giant cell arteritis (GCA) is the most frequent type of vasculitis, occurring in people older than 50 years. So far, treatment has been limited to corticosteroids and methotrexate only. Areas covered: Interleukin-6 (IL-6) plays a role in the pathophysiology of GCA. This review covers recent advances in the treatment of GCA with tocilizumab (TCZ), which specifically binds to both soluble and membrane-bound IL-6R and inhibits IL-6R-mediated signaling. Expert commentary: Two randomized controlled trials recently showed the efficacy of the IL-6 receptors inhibitor monoclonal antibody TCZ for the induction and maintenance of remission in patients with new-onset and relapsing GCA...
April 20, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29676318/diagnostic-positron-emission-tomography-computed-tomography-in-clinically-elusive-giant-cell-arteritis
#4
Ryian Mohamed, Deyl Djama, Tariq Ayoub
No abstract text is available yet for this article.
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676201/prognosis-and-monitoring-of-giant-cell-arteritis-and-associated-complications
#5
Tanaz A Kermani, Kenneth J Warrington
Giant cell arteritis (GCA) is the most common systemic vasculitis in people over the age of 50 years. Prospective imaging studies in GCA highlight the systemic nature of this vasculitis. Areas covered: This review summarizes literature using PubMed on complications of GCA and its treatment. Emphasis was placed on articles published within the past 5 years. Disease associated complications including vision loss from arteritic anterior ischemic optic neuropathy, large-artery stenoses and ischemia, and, aortic aneurysms and dissections...
April 20, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29673627/transient-monocular-blindness-vascular-causes-and-differential-diagnoses
#6
REVIEW
S Bidot, D Biotti
Transient monocular blindness is an acute episode of ischemic origin in which one eye has profound visual loss, followed by full recovery within one hour. Transient monocular blindness most often occurs in the setting of retinal ischemia secondary to carotid embolism, but other mechanisms have been reported, including thrombosis (most often in the setting of giant cell arteritis), hemodynamic disorders (secondary to severe carotid stenosis), or vasospasm. Transient monocular blindness is considered a transient ischemic attack originating in the carotid arteries, and must be managed the same as transient ischemic attack involving the brain, in order to prevent a subsequent stroke...
April 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29671039/three-days-of-high-dose-glucocorticoid-treatment-attenuates-large-vessel-18f-fdg-uptake-in-large-vessel-giant-cell-arteritis-but-with-a-limited-impact-on-diagnostic-accuracy
#7
Berit Dalsgaard Nielsen, Lars Christian Gormsen, Ib Tønder Hansen, Kresten Krarup Keller, Philip Therkildsen, Ellen-Margrethe Hauge
PURPOSE: To evaluate the in-treatment diagnostic accuracy of FDG PET/CT in large-vessel giant cell arteritis (LV-GCA) by serial scans before and after a short course of high-dose glucocorticoid treatment. METHODS: Twenty-four glucocorticoid-naïve patients with new-onset PET/CT verified LV-GCA (pre-treatment baseline PET) were prospectively included. Excluded were patients with a previous history of GCA or polymyalgia rheumatica, LV-GCA-mimicking conditions and patients on immunosuppressive therapy...
April 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29667308/diagnosis-and-management-of-giant-cell-arteritis-an-asia-pacific-perspective
#8
Jem V Ninan, Susan Lester, Catherine L Hill
No abstract text is available yet for this article.
April 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29666047/comparison-of-magnetic-resonance-angiography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-in-large-vessel-vasculitis
#9
Kaitlin A Quinn, Mark A Ahlman, Ashkan A Malayeri, Jamie Marko, Ali Cahid Civelek, Joel S Rosenblum, Armin A Bagheri, Peter A Merkel, Elaine Novakovich, Peter C Grayson
OBJECTIVES: To assess agreement between interpretation of magnetic resonance angiography (MRA) and 18 F-fluorodeoxyglucose positron emission tomography (PET) for disease extent and disease activity in large-vessel vasculitis (LVV) and determine associations between imaging and clinical assessments. METHODS: Patients with giant cell arteritis (GCA), Takayasu's arteritis (TAK) and comparators were recruited into a prospective, observational cohort. Imaging and clinical assessments were performed concurrently, blinded to each other...
April 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29665349/isolated-arteritis-of-both-lower-limbs
#10
Miroslav Průcha, Alena Šnajdrová, Pavel Zdráhal
Isolated arteritis of the lower limb vessels is an extremely rare condition. The use of modern vascular imaging techniques substantially facilitates and accelerates the diagnostics. In the isolated lower limb arteritis, it is always necessary to exclude Takayasu's and giant-cell arteritis. We present the case of a female patient with an isolated lower extremity arteritis without any other symptoms of systemic vascular damage or systemic autoimmune disease. Immunosuppressive therapy is obligatory in this case...
2018: Prague Medical Report
https://www.readbyqxmd.com/read/29650638/-actinomyces-cavernous-sinus-infection-a-case-and-systematic-literature-review
#11
Michal Lubomski, James Dalgliesh, Kenneth Lee, Omprakash Damodaran, Genevieve McKew, Stephen Reddel
A 63-year-old man presented with a 2-month history of progressive right-sided exophthalmos, painful ophthalmoplegia and fevers. As more features developed, he was diagnosed with giant cell arteritis then Tolosa-Hunt syndrome and transiently responded to corticosteroids. A bland cerebrospinal fluid and highly metabolically active brain (18 F)-fluoro-D-glucose-positron emission tomography suggested lymphoma. Biopsy of the mass showed sulphur granules with Gram-positive filamentous bacteria with Actinomyces -like colonies...
April 12, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29648680/what-is-the-current-evidence-for-disease-subsets-in-giant-cell-arteritis
#12
REVIEW
Kornelis S M van der Geest, Maria Sandovici, Yannick van Sleen, Jan-Stephan Sanders, Nicolaas A Bos, Wayel H Abdulahad, Coen A Stegeman, Peter Heeringa, Abraham Rutgers, Cees G M Kallenberg, Annemieke M H Boots, Elisabeth Brouwer
Giant cell arteritis (GCA) is an autoimmune vasculitis affecting large and medium-sized arteries. Ample evidence indicates that GCA is a heterogeneous disease in terms of symptoms, immune pathology and response to treatment. In the current review, we discuss the evidence for disease subsets in GCA. We describe clinical and immunological characteristics that may impact the risk for cranial ischemic symptoms, relapse rates and long-term glucocorticoid requirements in GCA patients. In addition, we discuss both proven and putative immunological targets for therapy in GCA patients with an unfavourable prognosis...
April 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29624864/takayasu-arteritis-and-giant-cell-arteritis-are-they-a-spectrum-of-the-same-disease
#13
Tanaz A Kermani
No abstract text is available yet for this article.
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29614532/-current-trends-in-diagnosis-and-treatment-of-giant-cell-arteritis
#14
Michael Czihal, Christian Lottspeich, Ulrich Hoffmann
Giant cell arteritis (GCA) is the most common form of the primary large vessel vasculitides and typically occurs in individuals aged ≥ 50 years. This concise review article discusses current trends in the management of GCA, including important developments in sonographic assessment (B-mode sonography, contrast enhanced ultrasound) and medical treatment (biological treatment with the interleukin-6 receptor alpha inhibitor tocilizumab).
April 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29611005/recent-advances-in-giant-cell-arteritis
#15
REVIEW
M Guevara, C S Kollipara
PURPOSE OF REVIEW: Giant cell arteritis (GCA) is the most common systemic vasculitis. GCA is categorized as a granulomatous vasculitis of large and medium size vessels. Majority of the symptoms and signs of GCA result from involvement of the aorta and its branches intra- and extracranial. Temporal artery biopsy continues to be the cardinal diagnostic procedure despite new imaging modalities for diagnosing GCA with cranial involvement. Great advances in awareness have led to improvement in preventing irreversible vision loss due to early diagnosis...
April 2, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29600479/ct-analysis-of-the-aorta-in-giant-cell-arteritis-a-case-control-study
#16
Pierre Emmanuel Berthod, Serge Aho-Glélé, Paul Ornetti, Olivier Chevallier, Hervé Devilliers, Frédéric Ricolfi, Bernard Bonnotte, Romaric Loffroy, Maxime Samson
OBJECTIVES: Giant cell arteritis (GCA) is a large-vessel vasculitis whose diagnosis is confirmed by temporal artery biopsy. However, involvement of large vessels, especially the aorta, can be shown by imaging, which plays an increasing role in GCA diagnosis. The threshold above which aortic wall thickening, as measured by computed tomography (CT), is considered pathological is controversial, with values ranging from 2 to 3 mm. This study assessed aortic morphology by CT scan and its diagnostic value in GCA...
March 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29595283/-polymyalgia-rheumatica
#17
Petr Němec, Andrea Šprláková-Puková, Zdeněk Řehák
Polymyalgia rheumatica is the most frequent inflammatory disease of people over 50 years of age. It mainly affects the Caucasian race and roughly 2-3 times as many women. From the viewpoint of etiology, polymyalgia rheumatica is a complex disease. Involved in its origin is genetic predisposition, factors of age and outer environment. 16-21 % of patients with polymyalgia rheumatica may at the same time have symptoms of giant cell arteritis. Diagnosis is made primarily on the basis of clinical symptoms and it is supported by the presence of laboratory signs of inflammation...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29589398/pathogenesis-of-polymyalgia-rheumatica
#18
G Guggino, A Ferrante, F Macaluso, G Triolo, F Ciccia
Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance between Th17 and Treg cells...
March 27, 2018: Reumatismo
https://www.readbyqxmd.com/read/29570475/tocilizumab-in-giant-cell-arteritis
#19
Vincent J Mariano, William H Frishman
Giant cell arteritis is a granulomatous immune-mediated vasculitis of medium and large vessels. It most commonly affects Caucasian females over the age of 50 and is the most common primary vasculitis in the United States. Treatment of this disease has classically been with high-dose corticosteroids, but this therapy has been associated with severe morbidity and mortality. Tocilizumab, a humanized monoclonal antibody targeting the interleukin-6 receptor, has been used with great efficacy and safety in rheumatoid arthritis and systemic-onset juvenile idiopathic arthritis...
March 22, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29561471/secondary-syphilis-mimicking-giant-cell-arteritis
#20
Nehal Narayan, Poppy Bennett, Cathleen Chan, Ben Rhodes
No abstract text is available yet for this article.
March 21, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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