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Giant cell arteritis

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https://www.readbyqxmd.com/read/28099197/relative-frequencies-of-arteritic-and-nonarteritic-anterior-ischemic-optic-neuropathy-in-an-arab-population
#1
Anna M Gruener, Jessica R Chang, Thomas M Bosley, Zakeya M Al-Sadah, Clarissa Kum, Timothy J McCulley
BACKGROUND: To evaluate the relative frequencies of arteritic and nonarteritic anterior ischemic optic neuropathy (AION) in an Arab population and to compare and contrast these findings with known epidemiological data from Caucasian populations. METHODS: A retrospective review of the medical records of all patients diagnosed with AION at the King Khaled Eye Specialist Hospital (KKESH) in Riyadh, Saudi Arabia, between 1997 and 2012. RESULTS: Of 171 patients with AION, 4 had biopsy-proven giant-cell arteritis (GCA)...
January 17, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28089985/giant-cell-arteritis-related-stroke-a-retrospective-multicenter-case-control-study
#2
Hubert de Boysson, Eric Liozon, Delphine Larivière, Maxime Samson, Jean-Jacques Parienti, Jonathan Boutemy, Gwénola Maigné, Nicolas Martin Silva, Kim Ly, Emmanuel Touzé, Bernard Bonnotte, Achille Aouba, Karim Sacré, Boris Bienvenu
OBJECTIVE: Our aim was to describe patients with giant cell arteritis (GCA)-related stroke and to compare them with a control group of GCA patients without stroke. METHODS: We created a retrospective multicenter cohort of patients with (1) GCA diagnosed according to the American College of Rheumatology criteria between 1995 and 2015, and (2) stroke occurring at the time of GCA diagnosis or occurring within 4 weeks of starting GCA therapy. The control group consisted of GCA patients without stroke...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28077689/giant-cell-arteritis-and-vascular-disease-risk-factors-and-outcomes-a-cohort-study-using-uk-clinical-practice-research-datalink
#3
Lin Li, Tuhina Neogi, Susan Jick
OBJECTIVE: To evaluate the associations between GCA and vascular diseases and other comorbidities in patients with GCA compared with non-vasculitis patients. METHODS: Using the UK-based Clinical Practice Research Datalink we identified 9778 newly diagnosed GCA patients in 1990-2014, and up to 10 non-vasculitis patients randomly matched to each case on age, sex, practice and years of history before cohort entry. We compared the distributions of 9 different pre-existing vascular diseases and 11 other comorbidities, and risks of incident vascular diseases and other comorbidities after cohort entry between GCA and non-vasculitis patients...
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28074266/fever-of-unknown-origin-giant-cell-arteritis-and-aortic-dissection
#4
K Hofheinz, S Bertz, J Wacker, G Schett, B Manger
Giant cell arteritis is one of the most frequent causes of pyrexia of unknown origin after infectious or malignant causes have been ruled out. In this case report we describe a 66-year old female patient, who after five weeks of remitting fever developed a life-threatening, painless severe aortic dissection. The timely use of modern imaging technologies such as magnetic resonance angiography or positron emission computed tomography could in the future be of help to recognize aortic involvement early and to avoid this devastating complication in patients with fever of unknown origin...
January 10, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28067080/-recent-advances-in-the-treatment-of-large-vessel-vasculitides
#5
Melinda Zsuzsanna Szabó, Emese Kiss
Giant cell arteritis and Takayasu arteritis classified to large vessel vasculitides have similar histopathology in the vascular wall proposing that these entities can be different phenotypes on a spectrum of a single disorder. Glucocorticoids are the mainstay of therapy combined with cyclophosphamide, azatioprine and mycofenolate mofetil, when it is required. However, a significant proportion of patients are glucocorticoid-dependent despite of the conventional disease-modifying antirheumatic drugs and suffer from serious side effects of the steroids, therefore alternate options for more effective disease management are needed...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28064210/characteristics-of-autoantibodies-targeting-14-3-3-proteins-and-their-association-with-clinical-features-in-newly-diagnosed-giant-cell-arteritis
#6
Anne Kistner, Marc B Bigler, Kathrin Glatz, Simon B Egli, Fabian S Baldin, Florian A Marquardsen, Matthias Mehling, Katharina M Rentsch, Daniel Staub, Markus Aschwanden, Mike Recher, Thomas Daikeler, Christoph T Berger
OBJECTIVES: Autoantibodies are useful biomarkers for diagnosing and monitoring treatment in some autoimmune diseases. Antibodies against isoforms of 14-3-3 protein have been proposed as biomarkers for the presence of aortic aneurysm in large-vessel vasculitis (LVV). Here, we aimed to evaluate the diagnostic role and potential immunopathological involvement of anti-14-3-3 antibodies in newly diagnosed LVV patients. METHODS: Antibodies against three isoforms of 14-3-3 (γ, ε and ζ) were measured in 90 subjects: 48 GCA and 3 Takayasu's arteritis (TA) patients, and 39 controls (non-inflammatory and inflammatory diseases), using a multiplexed bead-based immunoassay and immunoprecipitation studies...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28041642/a-genome-wide-association-study-identifies-risk-alleles-in-plasminogen-and-p4ha2-associated-with-giant-cell-arteritis
#7
F David Carmona, Augusto Vaglio, Sarah L Mackie, José Hernández-Rodríguez, Paul A Monach, Santos Castañeda, Roser Solans, Inmaculada C Morado, Javier Narváez, Marc Ramentol-Sintas, Colin T Pease, Bhaskar Dasgupta, Richard Watts, Nader Khalidi, Carol A Langford, Steven Ytterberg, Luigi Boiardi, Lorenzo Beretta, Marcello Govoni, Giacomo Emmi, Francesco Bonatti, Marco A Cimmino, Torsten Witte, Thomas Neumann, Julia Holle, Verena Schönau, Laurent Sailler, Thomas Papo, Julien Haroche, Alfred Mahr, Luc Mouthon, Øyvind Molberg, Andreas P Diamantopoulos, Alexandre Voskuyl, Elisabeth Brouwer, Thomas Daikeler, Christoph T Berger, Eamonn S Molloy, Lorraine O'Neill, Daniel Blockmans, Benedicte A Lie, Paul Mclaren, Timothy J Vyse, Cisca Wijmenga, Yannick Allanore, Bobby P C Koeleman, Jennifer H Barrett, María C Cid, Carlo Salvarani, Peter A Merkel, Ann W Morgan, Miguel A González-Gay, Javier Martín
Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50 years in Western countries. To shed light onto the genetic background influencing susceptibility for GCA, we performed a genome-wide association screening in a well-powered study cohort. After imputation, 1,844,133 genetic variants were analyzed in 2,134 case subjects and 9,125 unaffected individuals from ten independent populations of European ancestry. Our data confirmed HLA class II as the strongest associated region (independent signals: rs9268905, p = 1...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28041616/giant-cell-arteritis
#8
REVIEW
Hyeon Jeong Cho, Justin Bloomberg, Jeffrey Nichols
No abstract text is available yet for this article.
December 29, 2016: Disease-a-month: DM
https://www.readbyqxmd.com/read/28040246/risk-of-mortality-in-patients-with-giant-cell-arteritis-a-systematic-review-and-meta-analysis
#9
REVIEW
Catherine L Hill, Rachel J Black, Johannes C Nossent, Carlee Ruediger, Leanne Nguyen, Jem V Ninan, Susan Lester
BACKGROUND: Previous studies of mortality associated with GCA have shown conflicting results. We conducted a systematic review and meta-analysis to determine the mortality risk in GCA patients compared to the general population. METHODS: We searched for published studies indexed in MEDLINE and EMBASE and the Cochrane database from inception to June 18, 2015 using the terms "giant cell arteritis" and "temporal arteritis" combined with the terms for death, mortality, and survival...
August 25, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28040244/serious-adverse-effects-associated-with-glucocorticoid-therapy-in-patients-with-giant-cell-arteritis-gca-a-nested-case-control-analysis
#10
Jessica C Wilson, Khaled Sarsour, Neil Collinson, Katie Tuckwell, David Musselman, Micki Klearman, Pavel Napalkov, Susan S Jick, John H Stone, Christoph R Meier
OBJECTIVE: Giant cell arteritis (GCA) is an inflammatory vasculitis preferentially affecting large and medium-sized arteries. High-dose oral glucocorticoids (GCs) are the mainstay of GCA therapy. Using data from the UK Clinical Practice Research Datalink (CPRD), we examined the risk of oral GC-related serious adverse events (SAEs) in a UK population of patients with giant cell arteritis (GCA). METHODS: We conducted a series of nested case-control analyses in GCA patients to examine the effect of increasing dose of prednisolone on the risk of developing diabetes, glaucoma, osteoporosis, fractures, serious infection requiring hospitalization, and death...
November 28, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28029908/pathology-of-ischemic-optic-neuropathy
#11
Hershel R Patel, Curtis E Margo
Ischemic optic neuropathy (ION) describes a state of hypoxic injury of the optic nerve. Clinically, ION is divided into anterior and posterior forms defined by the presence or absence of optic disc swelling, respectively. It is further classified as arteritic when secondary to vasculitis, and nonarteritic when not. The site of vascular occlusion for anterior ION from giant cell arteritis is the short posterior ciliary arteries, but mechanical vascular obstruction does not play a role in most nonarteritic cases...
January 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28029235/editorial-defining-and-refining-the-risk-of-venous-thromboembolism-in-giant-cell-arteritis
#12
EDITORIAL
Paul A Monach
No abstract text is available yet for this article.
January 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28029234/temporal-trends-of-venous-thromboembolism-risk-before-and-after-diagnosis-of-giant-cell-arteritis
#13
Sebastian Unizony, Na Lu, Gunnar Tomasson, Yuqing Zhang, Peter A Merkel, John H Stone, J Antonio Aviña-Zubieta, Hyon K Choi
OBJECTIVE: Giant cell arteritis (GCA) and the use of glucocorticoids have both been associated with increased risk of venous thromboembolism (VTE). However, the possibility of confounding by indication has not been investigated. We undertook this study to examine the temporal risk of VTE in GCA patients before and after GCA diagnosis, accounting for confounders including glucocorticoid treatment. METHODS: We conducted a matched cohort study using an electronic medical record database representative of the UK population (1990-2013)...
January 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27998620/newly-diagnosed-vs-relapsing-giant-cell-arteritis-baseline-data-from-the-giacta-trial
#14
Katie Tuckwell, Neil Collinson, Sophie Dimonaco, Micki Klearman, Daniel Blockmans, Elisabeth Brouwer, Maria C Cid, Bhaskar Dasgupta, Juergen Rech, Carlo Salvarani, Sebastian H Unizony, John H Stone
OBJECTIVE: To report entry criteria and clinical features of patients with newly diagnosed and relapsing giant cell arteritis (GCA) enrolled in a randomized trial of tocilizumab, an interleukin-6 receptor-alpha inhibitor. METHODS: Newly diagnosed GCA was defined as diagnosis ≤6 weeks before baseline. Relapsing GCA was defined as diagnosis >6 weeks before baseline with ≥2 consecutive weeks of prednisone ≥40mg/day. All patients had active GCA within 6 weeks of baseline...
November 15, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27994267/widespread-headache-as-the-first-clinical-manifestation-of-giant-cell-arteritis-in-patients-affected-by-polymyalgia-rheumatica
#15
Ciro Manzo
INTRODUCTION: In giant cell arteritis (GCA) headache of new onset due to inflammatory involvement of the temporal artery (TA) represents a diagnostic criterion. A widespread headache (WH) with scalp tenderness due to cranial arteritis can represent another manifestation of GCA. MATERIAL AND METHODS: In 225 elderly patients with polymyalgia rheumatica (PMR) followed in our rheumatologic outpatient clinic from 2004 until June 2016, the frequency of WH as the first clinical manifestation of GCA was evaluated...
2016: Reumatologia
https://www.readbyqxmd.com/read/27988436/a-scoping-review-of-the-use-of-non-biologic-disease-modifying-anti-rheumatic-drugs-in-the-management-of-large-vessel-vasculitis
#16
REVIEW
Durga Prasanna Misra, Aman Sharma, Tamilarasu Kadhiravan, Vir Singh Negi
Takayasu's arteritis (TA) and Giant cell arteritis (GCA) comprise the large vessel vasculitides (LVV). Patients with LVV are treated with disease-modifying anti-rheumatic drugs (DMARDs), both conventional (cDMARDs) and biologic (bDMARDs). We undertook a scoping review to assess the effectiveness of cDMARDs in TA and GCA. We could identify 11 studies in TA and 18 studies in GCA. There were only 3 randomized controlled trials on methotrexate, one on hydroxychloroquine and two on cyclosporine in GCA, the others being case series (including all studies on TA)...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27974093/serum-immunoglobulin-g4-in-giant-cell-arteritis-and-polymyalgia-rheumatica
#17
Mara Burkel, Fabian Arndt, Jan-Henrik Schirmer, Frank Moosig, Julia Holle
OBJECTIVES: To date, no specific serum marker for giant cell arteritis and polymyalgia rheumatica has been established in routine practice. Therefore, the aim of this study was to examine whether immunoglobulin G4 serum concentrations could be a potential biomarker for the differentiation of both diseases. METHODS: Serum immunoglobulin G4 (IgG4) concentrations were measured in patients with giant cell arteritis (n=41) and polymyalgia rheumatica (n=27) by an in-house enzyme-linked immunosorbent assay...
December 2, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27940595/the-association-of-vascular-risk-factors-with-visual-loss-in-giant-cell-arteritis
#18
Max Yates, Alex J MacGregor, Joanna Robson, Anthea Craven, Peter A Merkel, Raashid A Luqmani, Richard A Watts
OBJECTIVE: Blindness is a recognized complication of GCA; however, the frequency of and risk factors for this complication have not been firmly established. The aim of this study was to examine the incidence and determinants of blindness in patients with GCA, using a large international cohort. METHODS: The analysis was conducted among subjects recruited into the Diagnosis and Classification Criteria in Vasculitis Study. The study captures consecutive patients presenting to clinic-based physicians...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27938961/clinical-predictors-of-positive-temporal-artery-biopsy
#19
Andrew Toren, Ezekiel Weis, Vivek Patel, Bethany Monteith, Steven Gilberg, David Jordan
OBJECTIVE: We investigated the ability of known clinical signs and symptoms, as well as common laboratory tests, to correctly predict a positive temporal artery biopsy. DESIGN: A prospective cohort study. PARTICIPANTS: Consecutive patients in a tertiary referral centre undergoing temporal artery biopsy. METHODS: Clinical information was collected using a predesigned questionnaire. Pathology results and laboratory information were collected from digital patient records...
December 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27927642/an-expanded-population-of-pathogenic-regulatory-t-cells-in-giant-cell-arteritis-is-abrogated-by-il-6-blockade-therapy
#20
Chie Miyabe, Yoshishige Miyabe, Klemen Strle, Nancy D Kim, John H Stone, Andrew D Luster, Sebastian Unizony
OBJECTIVES: Randomised-controlled trials have recently proven the efficacy of the interleukin (IL)-6 receptor antagonist tocilizumab (TCZ) in giant cell arteritis (GCA). However, the mechanism of action of IL-6 blockade in this disease is unknown. Moreover, the role of regulatory T (Treg) cells in the pathogenesis of GCA remains underexplored. Given the plasticity of Tregs and the importance of IL-6 in their biology, we hypothesised that TCZ might modulate the Treg response in GCA. We therefore characterised the Treg compartment of patients with GCA treated with TCZ...
December 7, 2016: Annals of the Rheumatic Diseases
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