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https://www.readbyqxmd.com/read/29232399/maternal-white-blood-cell-count-cannot-identify-the-presence-of-microbial-invasion-of-the-amniotic-cavity-or-intra-amniotic-inflammation-in-women-with-preterm-prelabor-rupture-of-membranes
#1
Ivana Musilova, Lenka Pliskova, Romana Gerychova, Petr Janku, Ondrej Simetka, Petr Matlak, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: The main aim of this study was to determine the relationship between the maternal white blood cell (WBC) count at the time of hospital admission in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) and the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI). The second aim was to test WBC diagnostic indices with respect to the presence of MIAC and/or IAI. METHODS: Four hundred and seventy-nine women with singleton pregnancies complicated by PPROM, between February 2012 and June 2017, were included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29231960/prospective-validation-of-a-screening-tool-to-identify-older-adults-in-need-of-a-driving-evaluation
#2
Marian E Betz, Jason S Haukoos, Robert Schwartz, Carolyn DiGuiseppi, Deepika Kandasamy, Brenda Beaty, Elizabeth Juarez-Colunga, David B Carr
OBJECTIVES: To prospectively validate and refine the 5-item "CRASH" screening tool for identifying older drivers needing a behind-the-wheel (BTW) test. DESIGN: Prospective observational study. SETTING: Geriatric and internal medicine primary care clinics affiliated with a tertiary care hospital and a local BTW program. PARTICIPANTS: Cognitively intact drivers aged 65 and older (N = 315). MEASUREMENTS: Participants completed baseline questionnaire (including CRASH tool) and assessments and BTW test (evaluator blinded to questionnaire results) and participated in 1-month telephone follow-up...
December 12, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29231957/eating-disorders-in-non-dance-performing-artists-a-systematic-literature-review
#3
REVIEW
Marianna E Kapsetaki, Charlie Easmon
PURPOSE: Previous literature on dancers and athletes has shown a large impact of eating disorders (EDs) on these individuals, but there is limited research on EDs affecting non-dance performing artists (i.e., musicians, actors, etc.). This systematic review aimed to identify and evaluate the literature on EDs in non-dance performing artists. METHODS: A systematic review of the literature was performed on 24 databases, using search terms related to EDs and non-dance performing artists...
December 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/29231186/-psychometric-properties-of-postpartum-depression-predictors-inventory-revised-prenatal-version-in-a-sample-of-spanish-pregnant-women
#4
María de la Fe Rodríguez-Muñoz, Laura Vallejo Slocker, María Eugenia Olivares Crespo, Nuria Izquierdo Méndez, Cristina Soto, Huynh-Nhu Le
OBJECTIVE: Prenatal depression is a major public health problem, therefore predicting and preventing it is a relevant objective for public health agendas. Consequently, it is important to have adequate screening tools to detect risk factors associated with prenatal depression. The aim of this study was to evaluate the psychometric properties reliability and factor structure of the Spanish version of the Postpartum Depression Predictors Inventory- Revised- Prenatal Version (PDI-R) in pregnant women who attend prenatal care in an urban hospital in Spain...
December 4, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/29231164/lapatinib-plus-capecitabine-in-patients-with-her2-positive-metastatic-breast-cancer-a%C3%A2-systematic-review%C3%A2
#5
Rebecca Madden, Sam Kosari, Gregory M Peterson, Nasser Bagheri, Jackson Thomas
OBJECTIVE: Human epidermal growth factor receptor 2 (HER2)-positive breast cancer, which accounts for 20 - 25% of cases of breast cancers, is highly aggressive. Due to cardiotoxicity and increasing resistance associated with trastuzumab, the first-line treatment, there is a need for effective second-line therapies in treating HER2-positive breast cancer. In this context, there has been increasing interest in the combination of lapatinib plus capecitabine. The aim of this systematic review was to assess the efficacy of lapatinib plus capecitabine for HER2-positive breast cancer after progression with trastuzumab therapy, in comparison with capecitabine monotherapy and other agents such as vinorelbine and trastuzumab emtansine...
December 12, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29231143/complex-network-study-of-the-immune-epitope-database-for-parasitic-organisms
#6
Severo Vazquez-Prieto, Esperanza Paniagua, Hugo Solana, Florencio M Ubeira
Complex network approach allows the representation and analysis of complex systems of interacting agents in an ordered and effective manner, increasing thus the probability of discovering significant properties of them. In the present study, we defined and built for the first time a complex network based on data obtained from Immune Epitope Database for parasitic organisms. We then considered the general topology, the node degree distribution, and the local structure (triadic census) of this network. In addition, we calculated 9 node centrality measures for observed network and reported a comparative study of the real network with three theoretical models to detect similarities or deviations from these ideal networks...
December 11, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29230877/neonatal-mouse-cortical-but-not-isogenic-human-astrocyte-feeder-layers-enhance-the-functional-maturation-of-induced-pluripotent-stem-cell-derived-neurons-in-culture
#7
Fritz W Lischka, Anastasia Efthymiou, Qiong Zhou, Michael D Nieves, Nikki M McCormack, Matthew D Wilkerson, Gauthaman Sukumar, Clifton L Dalgard, Martin L Doughty
Human induced pluripotent stem (iPS) cell-derived neurons and astrocytes are attractive cellular tools for nervous system disease modeling and drug screening. Optimal utilization of these tools requires differentiation protocols that efficiently generate functional cell phenotypes in vitro. As nervous system function is dependent on networked neuronal activity involving both neuronal and astrocytic synaptic functions, we examined astrocyte effects on the functional maturation of neurons from human iPS cell-derived neural stem cells (NSCs)...
December 12, 2017: Glia
https://www.readbyqxmd.com/read/29230802/measurement-properties-of-instruments-that-assess-participation-in-young-people-with-autism-spectrum-disorder-a-systematic-review
#8
REVIEW
Francesca Lami, Kristine Egberts, Alexandra Ure, Rowena Conroy, Katrina Williams
AIM: To systematically review the measurement properties of instruments assessing participation in young people with autism spectrum disorder (ASD). METHOD: A search was performed in MEDLINE, PsycINFO, and PubMed combining three constructs ('ASD', 'test of participation', 'measurement properties'). Results were restricted to articles including people aged 6 to 29 years. The 2539 identified articles were independently screened by two reviewers. For the included articles, data were extracted using standard forms and their risk of bias was assessed...
December 12, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29230310/applying-systems-thinking-to-task-shifting-for-mental-health-using-lay-providers-a-review-of-the-evidence
#9
REVIEW
D Javadi, I Feldhaus, A Mancuso, A Ghaffar
Objective: This paper seeks to review the available evidence to determine whether a systems approach is employed in the implementation and evaluation of task shifting for mental health using lay providers in low- and middle-income countries, and to highlight system-wide effects of task-shifting strategies in order to better inform efforts to strength community mental health systems. Methods: Pubmed, CINAHL, and Cochrane Library databases were searched. Articles were screened by two independent reviewers with a third reviewer resolving discrepancies...
2017: Global Mental Health
https://www.readbyqxmd.com/read/29229743/meta-analysis-and-systematic-review-to-assess-the-role-of-soluble-fms-like-tyrosine-kinase-1-and-placenta-growth-factor-ratio-in-prediction-of-preeclampsia-the-sappphire-study
#10
Swati Agrawal, Ana Sofia Cerdeira, Christopher Redman, Manu Vatish
Preeclampsia is a major cause of morbidity and mortality worldwide. Numerous candidate biomarkers have been proposed for diagnosis and prediction of preeclampsia. Measurement of maternal circulating angiogenesis biomarker as the ratio of sFlt-1 (soluble FMS-like tyrosine kinase-1; an antiangiogenic factor)/PlGF (placental growth factor; an angiogenic factor) reflects the antiangiogenic balance that characterizes incipient or overt preeclampsia. The ratio increases before the onset of the disease and thus may help in predicting preeclampsia...
December 11, 2017: Hypertension
https://www.readbyqxmd.com/read/29229658/effectiveness-of-acupuncture-for-cancer-pain-protocol-for-an-umbrella-review-and-meta-analyses-of-controlled-trials
#11
Yihan He, Yihong Liu, Brian H May, Anthony Lin Zhang, Haibo Zhang, ChuanJian Lu, Lihong Yang, Xinfeng Guo, Charlie Changli Xue
INTRODUCTION: The National Comprehensive Cancer Network guidelines for adult cancer pain indicate that acupuncture and related therapies may be valuable additions to pharmacological interventions for pain management. Of the systematic reviews related to this topic, some concluded that acupuncture was promising for alleviating cancer pain, while others argued that the evidence was insufficient to support its effectiveness. METHODS AND ANALYSIS: This review will consist of three components: (1) synthesis of findings from existing systematic reviews; (2) updated meta-analyses of randomised clinical trials and (3) analyses of results of other types of clinical studies...
December 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/29228998/capturing-health-and-eating-status-through-a-nutritional-perception-screening-questionnaire-npsq9-in-a-randomised-internet-based-personalised-nutrition-intervention-the-food4me-study
#12
Rodrigo San-Cristobal, Santiago Navas-Carretero, Carlos Celis-Morales, Katherine M Livingstone, Barbara Stewart-Knox, Audrey Rankin, Anna L Macready, Rosalind Fallaize, Clare B O'Donovan, Hannah Forster, Clara Woolhead, Marianne C Walsh, Christina P Lambrinou, George Moschonis, Yannis Manios, Miroslaw Jarosz, Hannelore Daniel, Eileen R Gibney, Lorraine Brennan, Thomas E Gundersen, Christian A Drevon, Mike Gibney, Cyril F M Marsaux, Wim H M Saris, Julie A Lovegrove, Lynn J Frewer, John C Mathers, J Alfredo Martinez
BACKGROUND: National guidelines emphasize healthy eating to promote wellbeing and prevention of non-communicable diseases. The perceived healthiness of food is determined by many factors affecting food intake. A positive perception of healthy eating has been shown to be associated with greater diet quality. Internet-based methodologies allow contact with large populations. Our present study aims to design and evaluate a short nutritional perception questionnaire, to be used as a screening tool for assessing nutritional status, and to predict an optimal level of personalisation in nutritional advice delivered via the Internet...
December 11, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29228985/investigating-the-burden-of-antibiotic-resistance-in-ethnic-minority-groups-in-high-income-countries-protocol-for-a-systematic-review-and-meta-analysis
#13
Hannah Lishman, Paul Aylin, Vivian Alividza, Enrique Castro-Sanchez, Anuja Chatterjee, Victor Mariano, Alan P Johnson, Samir Jeraj, Céire Costelloe
BACKGROUND: Antibiotic resistance (ABR) is an urgent problem globally, with overuse and misuse of antibiotics being one of the main drivers of antibiotic-resistant infections. There is increasing evidence that the burden of community-acquired infections such as urinary tract infections and bloodstream infections (both susceptible and resistant) may differ by ethnicity, although the reasons behind this relationship are not well defined. It has been demonstrated that socioeconomic status and ethnicity are often highly correlated with each other; however, it is not yet known whether accounting for deprivation completely explains any discrepancy seen in infection risk...
December 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29228932/narratives-of-community-engagement-a-systematic-review-derived-conceptual-framework-for-public-health-interventions
#14
Ginny Brunton, James Thomas, Alison O'Mara-Eves, Farah Jamal, Sandy Oliver, Josephine Kavanagh
BACKGROUND: Government policy increasingly supports engaging communities to promote health. It is critical to consider whether such strategies are effective, for whom, and under what circumstances. However, 'community engagement' is defined in diverse ways and employed for different reasons. Considering the theory and context we developed a conceptual framework which informs understanding about what makes an effective (or ineffective) community engagement intervention. METHODS: We conducted a systematic review of community engagement in public health interventions using: stakeholder involvement; searching, screening, appraisal and coding of research literature; and iterative thematic syntheses and meta-analysis...
December 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29228189/a-snapshot-of-3649-web-based-services-published-between-1994-and-2017-shows-a-decrease-in-availability-after-2-years
#15
Ágnes Osz, Lorinc Sándor Pongor, Danuta Szirmai, Balázs Gyorffy
Background: The long-term availability of online Web services is of utmost importance to ensure reproducibility of analytical results. However, because of lack of maintenance following acceptance, many servers become unavailable after a short period of time. Our aim was to monitor the accessibility and the decay rate of published Web services as well as to determine the factors underlying trends changes. Methods: We searched PubMed to identify publications containing Web server-related terms published between 1994 and 2017...
December 8, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29228026/rapid-analyses-of-dry-matter-content-and-carotenoids-in-fresh-cassava-roots-using-a-portable-visible-and-near-infrared-spectrometer-vis-nirs
#16
Ugochukwu N Ikeogu, Fabrice Davrieux, Dominique Dufour, Hernan Ceballos, Chiedozie N Egesi, Jean-Luc Jannink
Portable Vis/NIRS are flexible tools for fast and unbiased analyses of constituents with minimal sample preparation. This study developed calibration models for dry matter content (DMC) and carotenoids in fresh cassava roots using a portable Vis/NIRS system. We examined the effects of eight data pre-treatment combinations on calibration models and assessed calibrations on processed and intact root samples. We compared Vis/NIRS derived-DMC to other phenotyping methods. The results of the study showed that the combination of standard normal variate and de-trend (SNVD) with first derivative calculated on two data points and no smoothing (SNVD+1111) was adequate for a robust model...
2017: PloS One
https://www.readbyqxmd.com/read/29227955/developing-and-validating-a-perinatal-depression-screening-tool-in-kenya-blending-western-criteria-with-local-idioms-a-mixed-methods-study
#17
Eric P Green, Hawa Tuli, Edith Kwobah, D Menya, Irene Chesire, Christina Schmidt
BACKGROUND: Routine screening for perinatal depression is not common in most primary health care settings. The U.S. Preventive Services Task Force only recently updated their recommendation on depression screening to specifically recommend screening during the pre- and postpartum periods. While practitioners in high-income countries can respond to this new recommendation by implementing one of several existing depression screening tools developed in Western contexts, such as the Edinburgh Postnatal Depression Scale (EPDS) or the Patient Health Questionnaire-9 (PHQ-9), these tools lack strong evidence of cross-cultural equivalence, validity for case finding, and precision in measuring response to treatment in developing countries...
December 2, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29227800/assessment-of-the-neuropsychiatric-comorbidities-in-chinese-children-with-epilepsy-using-the-mini-kid-tool
#18
Taoli Li, Hao Zhou, Yijie Li, Chunpei Li, Yunjian Zhang, Yuanfeng Zhou, Yi Wang
This study aimed to assess neuropsychiatric comorbidities and analyze risk factors in Chinese children with epilepsy. Children with epilepsy aged between 6 and 16 years from the Children's Hospital of Fudan University were included. Children with asthma and typically developing children were matched for age and gender, and served as control groups. Neuropsychiatric disorders were assessed by interviewing the parents or guardians using the Mini International Neuropsychiatric Interview for children (MINI-KID) (parent version)...
November 24, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29227795/divergent-effects-of-levetiracetam-and-tiagabine-against-spontaneous-seizures-in-adult-rats-following-neonatal-hypoxia
#19
Raymond Dunn, Bridget N Queenan, Daniel T S Pak, Patrick A Forcelli
Animal models are valuable tools for screening novel therapies for patients who suffer from epilepsy. However, a wide array of models are necessary to cover the diversity of human epilepsies. In humans, neonatal hypoxia (or hypoxia-ischemia) is one of the most common causes of epilepsy early in life. Hypoxia-induced seizures (HS) during the neonatal period can also lead to spontaneous seizures in adulthood. This phenomenon, i.e., early-life hypoxia leading to adult epilepsy - is also seen in experimental models, including rats...
December 5, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29227678/an-old-story-in-the-parallel-synthesis-world-an-approach-to-hydantoin-libraries
#20
Andrey Bogolubsky, Yurii S Moroz, Olena Savych, Sergey Pipko, Angelika Konovets, Maxim O Platonov, Oleksandr V Vasylchenko, Vasyl V Hurmach, Oleksandr O Grygorenko
An approach to the parallel synthesis of hydantoin libraries by reaction of in situ generated 2,2,2-trifluoroethylcarbamates and α-amino esters was developed. To demonstrate utility of the method, a library of 1158 hydantoins designed according to the lead-likeness criteria (MW 200…350, cLogP -1…3) was prepared. The success rate of the method was analyzed as a function of physico-chemical parameters of the products, and it was found that the method can be considered as a tool for lead-oriented synthesis...
December 11, 2017: ACS Combinatorial Science
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