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https://www.readbyqxmd.com/read/29666893/pitfalls-in-bone-density-monitoring-in-prostate-cancer-during-anti-resorptive-treatment
#1
Y-M Cheung, S K Ramchand, M Grossmann
A 74-year-old man presented to the Andrology Clinic for management of potential complications of androgen deprivation therapy for prostate cancer. He had a rising prostate-specific antigen with a concurrent rise in alkaline phosphatase and bone remodeling markers. This was despite treatment with a radical prostatectomy, androgen deprivation, and anti-resorptive therapy. A follow-up dual-energy X-ray absorptiometry scan revealed a marked increase in his bone mineral density at both the lumbar spine and femoral neck...
April 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29666747/symphysis-pubis-osteomyelitis-an-uncommon-complication-after-robotic-assisted-radical-prostatectomy-case-description-with-literature-review
#2
Jad A Degheili, Mazen M Mansour, Rami W Nasr
Prostate cancer is the most common solid cancer among American men. Although there are various modalities for treatment, including radical prostatectomy among many others, the former is, nevertheless, not without any accompanied complications. Other than the well-known surgical complications such as erectile dysfunction, urinary incontinence, and voiding dysfunction, osteomyelitis of the symphysis pubis is not a well-understood complication, with various hypotheses explaining its pathogenesis. Although osteomyelitis of the pubis symphysis has been reported after endoscopic urological procedures such as transurethral resection of the prostate, it has rarely been reported after robotic surgeries...
2018: Case Reports in Urology
https://www.readbyqxmd.com/read/29665832/volumetric-and-dosimetric-comparison-of-organs-at-risk-between-the-prone-and-supine-positions-in-postoperative-radiotherapy-for-prostate-cancer
#3
Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe, Keiichi Nakagawa
BACKGROUND: The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radiotherapy for prostate cancer after prostatectomy. METHODS: Seventeen patients who received intensity-modulated radiation therapy (66 Gy in 33 fractions) as adjuvant or salvage therapy after prostatectomy were evaluated. All patients underwent CT scans in both the prone (on a belly board) and supine positions...
April 17, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29664244/the-role-of-68ga-psma-pet-ct-scan-in-biochemical-recurrence-after-primary-treatment-for-prostate-cancer-a-systematic-review-of-literature
#4
Ahmed Eissa, Ahmed El Sherbiny, Rafael F Coelho, Jens Rassweiler, John W Davis, Francesco Porpiglia, Vipul R Patel, Napoleone Prandini, Salvatore Micali, Maria C Sighinolfi, Stefano Puliatti, Bernardo Rocco, Giampaolo Bianchi
INTRODUCTION: Recurrence after primary treatment of prostate cancer is one of the major challenges facing urologists. Biochemical recurrence is not rare and occurs in up to one third of the patients undergoing radical prostatectomy. Management of biochemical recurrence is tailored according to the site and the burden of recurrence. Therefore, developing an imaging technique to early detect recurrent lesions represents an urgent need. Positron emission tomography (PET) of 68Ga-labelled prostate-specific membrane antigen (68Ga-PSMA) is an emerging imaging modality that seems to be a promising tool with capability to localize recurrent prostate cancer...
April 17, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29663462/survival-benefit-of-local-versus-no-local-treatment-for-metastatic-prostate-cancer-impact-of-baseline-psa-and-metastatic-substages
#5
Raisa S Pompe, Derya Tilki, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Marco Bandini, Michele Marchioni, Philipp Gild, Zhe Tian, Nicola Fossati, Luca Cindolo, Shahrokh F Shariat, Hartwig Huland, Markus Graefen, Alberto Briganti, Pierre I Karakiewicz
BACKGROUND: To test whether local treatment (LT), namely radical prostatectomy (RP) or brachytherapy (BT) still confers a survival benefit versus no local treatment (NLT), when adjusted for baseline PSA (bPSA). To further examine whether the effect of LT might be modulated according to bPSA and M1 substages. METHODS: Of 13 906 mPCa patients within the SEER (2004-2014), 375 underwent RP, 175 BT, and 13 356 NLT. Multivariable competing risks regression (MVA CRR) analyses after 1:2 propensity score matching assessed the impact of LT versus NLT on cancer specific mortality (CSM)...
April 16, 2018: Prostate
https://www.readbyqxmd.com/read/29663179/the-impact-of-obesity-on-pulmonary-deterioration-in-patients-undergoing-robotic-assisted-laparoscopic-prostatectomy
#6
Sebastian Blecha, Marion Harth, Florian Zeman, Timo Seyfried, Matthias Lubnow, Maximilian Burger, Stefan Denzinger, Michael T Pawlik
Obesity affects respiratory and hemodynamic function in anesthetized patients. The aim of this study was to evaluate the influence of the body mass index (BMI) on pulmonary changes in a permanent 45° steep Trendelenburg position (STP) during robotic-assisted laparoscopic prostatectomy (RALP). 51 patients undergoing RALP under standardized anesthesia were included. Perioperative pulmonary function and oxygenation were measured in awake patients (T0 ), 20 min after the induction of anesthesia (T1 ), after insufflation of the abdomen in supine position (T2 ), after 30 min in STP (T3 ), when controlling Santorini's plexus in STP (T4 ), before awakening while supine (T5 ), and after 45 min in the recovery room (T6 )...
April 16, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29663110/neutrophil-lymphocyte-and-platelet-counts-and-risk-of-prostate-cancer-outcomes-in-white-and-black-men-results-from-the-search-database
#7
Adriana C Vidal, Lauren E Howard, Amanda de Hoedt, Matthew R Cooperberg, Christopher J Kane, William J Aronson, Martha K Terris, Christopher L Amling, Emanuela Taioli, Jay H Fowke, Stephen J Freedland
PURPOSE: Systemic inflammation, as measured by C-reactive protein, has been linked with poor prostate cancer (PC) outcomes, predominantly in white men. Whether other immune measures like white blood cell counts are correlated with PC progression and whether results vary by race is unknown. We examined whether complete blood count (CBC) parameters were associated with PC outcomes and whether these associations varied by race. METHODS: Analyses include 1,826 radical prostatectomy patients from six VA hospitals followed through medical record review for biochemical recurrence (BCR)...
April 17, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29662622/quantitative-parameters-in-dynamic-contrast-enhanced-magnetic-resonance-imaging-for-the-detection-and-characterization-of-prostate-cancer
#8
Cheng Wei, Bowen Jin, Magdalena Szewczyk-Bieda, Stephen Gandy, Stephen Lang, Yilong Zhang, Zhihong Huang, Ghulam Nabi
Objectives: to assess the diagnostic accuracy of quantitative parameters of DCE-MRI in multi-parametric MRI (mpMRI) in comparison to the histopathology (including Gleason grade) of prostate cancer. Patients and methods: 150 men with suspected prostate cancer (abnormal digital rectum examination and or elevated prostate-specific antigen) received pre-biopsy 3T mpMRI and were recruited into peer-reviewed, protocol-based prospective study. The DCE-MRI quantitative parameters ( Ktrans (influx transfer constant) and kep (efflux rate constant)) of the cancerous and normal areas were recorded using four different kinetic models employing Olea Sphere (Olea Medical, La Ciotat, France)...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662542/meta-analysis-of-studies-comparing-oncologic-outcomes-of-radical-prostatectomy-and-brachytherapy-for-localized-prostate-cancer
#9
Gabriele Cozzi, Gennaro Musi, Roberto Bianchi, Danilo Bottero, Antonio Brescia, Antonio Cioffi, Giovanni Cordima, Maurizio Delor, Ettore Di Trapani, Matteo Ferro, Deliu Victor Matei, Andrea Russo, Francesco Alessandro Mistretta, Ottavio De Cobelli
Background: The aim of this study was to compare oncologic outcomes of radical prostatectomy (RP) with brachytherapy (BT). Methods: A literature review was conducted according to the 'Preferred reporting items for systematic reviews and meta-analyses' (PRISMA) statement. We included studies reporting comparative oncologic outcomes of RP versus BT for localized prostate cancer (PCa). From each comparative study, we extracted the study design, the number and features of the included patients, and the oncologic outcomes expressed as all-cause mortality (ACM), PCa-specific mortality (PCSM) or, when the former were unavailable, as biochemical recurrence (BCR)...
November 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29661963/obesity-suppresses-tumor-attributable-psa-affecting-risk-categorization
#10
Ken Chow, Stefano Mangiola, Jaideep Vazirani, Justin S Peters, Anthony J Costello, Christopher M Hovens, Niall M Corcoran
Obesity is linked with more aggressive prostate cancer and higher rates of disease recurrence post treatment. It is unclear if this is due to specific tumor-promoting effects of obesity or diagnostic bias. Patients undergoing prostatectomy were categorized according to their body mass index (BMI). Expected prostate-specific antigen (PSA) levels were calculated for each patient based on tumor characteristics. The effect of obesity on the accuracy of pre-treatment risk categorization was determined, and mediation analysis was used to identify the contribution of biologic vs non-biologic mechanisms to the observed increased risk of biochemical recurrence...
May 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29661718/the-gleason-pattern-4-in-radical-prostatectomy-specimens-in-current-practice-quantification-morphology-and-concordance-with-biopsy
#11
Maiara Ferreira de Souza, André Luis Cardoso de Azevedo Araujo, Mariana Trindade da Silva, Daniel Abensur Athanazio
PURPOSE: The upgrading of a prostate acinar adenocarcinoma grade group 1 (GG1) between needle biopsy and prostatectomy is common. The extent of high-grade tumor and cribriform morphology are currently suggested as prognostic factors. METHODS: We reviewed 159 prostatectomy specimens from a private laboratory and an academic/public institution in Salvador, Bahia. RESULTS: Tumors signed as GG1 at biopsy were upgraded in 59% of all cases. These tumors showed a low frequency of non-focal extraprostatic extension (one case, 3%), extensive positive surgical margins (two cases, 6%) and seminal vesicle invasion (one case, 3%)...
December 18, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29660918/contrast-enhanced-ultrasound-ceus-with-mri-image-fusion-for-monitoring-focal-therapy-of-prostate-cancer-with-high-intensity-focused-ultrasound-hifu-1
#12
M Apfelbeck, D-A Clevert, J Ricke, C Stief, B Schlenker
INTRODUCTION: Reduced acceptance of radical prostatectomy in patients with low risk or intermediate risk prostate cancer has significantly changed treatment strategies in prostate cancer (PCa) during the last years. Focal therapy of the prostate with high intensity focused ultrasound (HIFU) is an organ-preserving treatment for prostate cancer with less impairment of health-related quality of life. Follow-up after HIFU therapy by imaging modalities remains a major problem as eg. MRI performs poorly...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660795/symptom-and-function-profiles-of-men-with-localized-prostate-cancer
#13
Bryce B Reeve, Xianming Tan, Ronald C Chen, Deborah S Usinger, Laura C Pinheiro
BACKGROUND: Men diagnosed with localized prostate cancer seek information on how treatment options may impact their health-related quality of life (HRQOL). The authors used latent profile analysis (LPA) to group men according to their symptom burden and functional status and to identify patient characteristics associated with each HRQOL profile. METHODS: Patients completed the Patient-Reported Outcomes Measurement Information System and the Expanded Prostate Index Composite measures 3 months after treatment initiation...
April 16, 2018: Cancer
https://www.readbyqxmd.com/read/29658683/extrafascial-robot-assisted-laparoscopic-radical-prostatectomy-ef-ralp-in-locally-advanced-prostate-cancer
#14
Vito Pansadoro, Aldo Brassetti
INTRODUCTION: Up to 26.5% of new dewly diagnosed prostate cancers (PCa) are locally advanced (LA). Although traditionally discouraged in this setting, radical prostatectomy (RP) lowers the risk of metastatic progression and cancer-specific death. We report a review of the available evidences and describe our surgical technique of Extrafascial robot-assisted RP. EVIDENCE ACQUISITION: The PubMed/Medline database was searched for "prostate cancer", "high-risk", "locally advanced", "prostatectomy"...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29658681/laparoscopic-radical-prostatectomy-in-2018-20-years-of-worldwide-experiences-experimentations-researches-and-refinements
#15
Aldo Brassetti, Renaud Bollens
INTRODUCTION: After the first feasibility report in 1997, a growing interest has risen in the urologic community for laparoscopic radical prostatectomy (LRP) and several authors have contributed to the evolution of the technique. We attempt a review of the available evidences and provide a broad framework of different technical refinements considering their impact on pentafecta. EVIDENCE ACQUISITION: The PubMed/Medline database was searched. Duplicates and "Expert opinion" papers were removed...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29656854/radical-prostatectomy-in-metastatic-castration-resistant-prostate-cancer-feasibility-safety-and-quality-of-life-outcomes
#16
Chad A Reichard, Justin R Gregg, Mary F Achim, Ana M Aparicio, Curtis A Pettaway, Louis L Pisters, John F Ward, John W Davis, Brian F Chapin
Ongoing prospective studies are evaluating treatment of the primary tumor in men with de novo metastatic prostate cancer (PCa). One potential benefit is prevention of morbidity from local progression. Thus, local therapy may be best applied selectively to men with local progression once resistance to first-line therapies has occurred. Here, we gather support for the hypothesis that radical prostatectomy (RP) is safe and preserves quality of life (QOL) when applied in men with metastatic castration-resistant PCa (mCRPC)...
April 12, 2018: European Urology
https://www.readbyqxmd.com/read/29656065/penile-prosthesis-in-solid-organ-transplant-recipients-a-matched-cohort-study
#17
Andrew Y Sun, Paurush Babbar, Bradley C Gill, Kenneth W Angermeier, Drogo K Montague
OBJECTIVES: To determine whether solid organ transplant (SOT) patients are at higher risk of developing complications after inflatable penile prosthesis (IPP) implantation. METHODS: We retrospectively reviewed outcomes data for all patients with SOT who underwent IPP placement at our institution. A cohort of age-matched IPP recipients without SOT were used as controls. RESULTS: We identified 26 patients who underwent SOT and IPP between 1999-2015, and 26 controls...
April 12, 2018: Urology
https://www.readbyqxmd.com/read/29653121/integration-and-diagnostic-accuracy-of-3t-non-endorectal-coil-prostate-mri-in-the-context-of-active-surveillance
#18
Nicole E Curci, Brian R Lane, Prasad R Shankar, Sabrina L Noyes, Andrew K Moriarty, Anthony Kubat, Chris Brede, Jeffrey S Montgomery, Gregory B Auffenberg, David C Miller, James E Montie, Arvin K George, Matthew S Davenport
OBJECTIVE: To evaluate the integration of 3T non-endorectal-coil multiparametric prostate MRI (mpMRI) at two high-volume practices that routinely use mpMRI in the setting of active surveillance. MATERIALS AND METHODS: This was an IRB-approved, HIPAA-compliant, dual-institution retrospective cohort study. Subjects undergoing 3T mpMRI without endorectal coil at either study institution over a 13-month period (8/1/2015-8/31/2016) were selected based on pre-defined criteria: clinical T1/T2 Gleason 6 prostate cancer, PSA<15 ng/mL, ≥40 years-old, mpMRI within 2 years of prostate biopsy, PI-RADS v2 score assigned...
April 10, 2018: Urology
https://www.readbyqxmd.com/read/29651763/computer-aided-diagnosis-prior-to-conventional-interpretation-of-prostate-mpmri-an-international-multi-reader-study
#19
Matthew D Greer, Nathan Lay, Joanna H Shih, Tristan Barrett, Leonardo Kayat Bittencourt, Samuel Borofsky, Ismail Kabakus, Yan Mee Law, Jamie Marko, Haytham Shebel, Francesca V Mertan, Maria J Merino, Bradford J Wood, Peter A Pinto, Ronald M Summers, Peter L Choyke, Baris Turkbey
OBJECTIVES: To evaluate if computer-aided diagnosis (CAD) prior to prostate multi-parametric MRI (mpMRI) can improve sensitivity and agreement between radiologists. METHODS: Nine radiologists (three each high, intermediate, low experience) from eight institutions participated. A total of 163 patients with 3-T mpMRI from 4/2012 to 6/2015 were included: 110 cancer patients with prostatectomy after mpMRI, 53 patients with no lesions on mpMRI and negative TRUS-guided biopsy...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29645348/retzius-sparing-robot-assisted-radical-prostatectomy-using-revo-i-robotic-surgical-system-surgical-technique-and-results-of-the-first-human-trial
#20
Ki Don Chang, Ali Abdel Raheem, Young Deuk Choi, Byung Ha Chung, Koon Ho Rha
PURPOSE: Recently, Revo-i® robotic surgical system has been proved to be safe in the preclinical animal studies. Our aim was to evaluate the safety and proficiency of Revo-i® robotic platform in the treatment of prostate cancer (PCa). PATIENTS AND METHODS: A prospective study was carried out on 17 male patients with clinically localized PCa from August 17, 2016, to Feb 23, 2017 at our urology department using Revo-i® . Patients underwent Retzius-sparing robot-assisted radical prostatectomy (RP-RARP)...
April 12, 2018: BJU International
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