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https://www.readbyqxmd.com/read/28719448/biopsy-proven-diffuse-mediastinal-prostate-cancer-metastases-negative-on-18f-fluorocholine-diagnosed-on-68ga-psma-and-18f-psma-pet-ct
#1
Guillaume Chaussé, Tamim Niazi, Gad Solomon Abikhzer, Stephan Michael Probst
A 72-year-old man with prostate cancer (stage T3b, Gleason score 7) treated by radical prostatectomy was found to have biochemical failure (prostate-specific antigen 8.5 ng/mL) and a suspicious growing nodularity at the left prostate bed on MRI. F-fluorocholine PET/CT failed to demonstrate any site of uptake suggestive of malignancy. A bone scan did exclude bone metastases. Ga-PSMA PET/CT revealed various positive lymph nodes in the supraclavicular, mediastinal, and hilar regions. This was confirmed on F-DCFPyl PET/CT, with the addition of a suspicious right axillary lymph node...
July 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28718690/predictors-of-short-term-and-long-term-incontinence-after-robot-assisted-radical-prostatectomy
#2
I-Hung Shao, Ying-Hsu Chang, Chun-Ming Hou, Zheng-Feng Lin, Chun-Te Wu
Purpose To determine retrospectively the prognostic factors for urinary incontinence following robot-assisted radical prostatectomy (RARP). Methods Altogether, 180 patients with localized prostate cancer underwent RARP (same surgeon). Preoperative physical status, disease characteristics, laboratory findings, and surgical technique were recorded and the patients checked 1, 6, 12, and 24 months after RARP regarding their contribution to predicting post-prostatectomy urinary incontinence (PPI). Results Overall, 114 (63...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28718165/surgical-techniques-to-optimize-early-urinary-continence-recovery-post-robot-assisted-radical-prostatectomy-for-prostate-cancer
#3
REVIEW
Ashwin N Sridhar, Mohammed Abozaid, Prabhakar Rajan, Prasanna Sooriakumaran, Greg Shaw, Senthil Nathan, John D Kelly, Tim P Briggs
PURPOSE OF REVIEW: A variety of different surgical techniques are thought to impact on urinary continence (UC) recovery in patients undergoing robot assisted radical prostatectomy (RARP) for prostate cancer. Herein, we review current evidence and propose a composite evidence-based technique to optimize UC recovery after RARP. RECENT FINDINGS: A literature search on studies reporting on surgical techniques to improve early continence recovery post robotic prostatectomy was conducted on PubMed and EMBASE...
September 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28717700/prostate-cancer-burden-at-the-uganda-cancer-institute
#4
Fred Okuku, Jackson Orem, George Holoya, Chris De Boer, Cheryl L Thompson, Matthew M Cooney
PURPOSE: In Uganda, the incidence of prostate cancer is increasing at a rate of 5.2% annually. Data describing presentation and outcomes for patients with prostate cancer are lacking. METHODS: A retrospective review of medical records for men with histologically confirmed prostate cancer at the Uganda Cancer Institute (UCI) from January 1 to December 17, 2012, was performed. RESULTS: Our sample included 182 men whose mean age was 69.5 years (standard deviation, 9...
August 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717538/assessment-of-prostate-cancer-with-integrated-ct-perfusion-using-a-sector-wise-approach
#5
Matteo Ferrari, Martin Huellner, Chantal Pauli, Burkhardt Seifert, Hansjörg Danuser, Patrick Veit-Haibach, Agostino Mattei
OBJECTIVE: The role of computed tomography perfusion (CTP) in characterizing primary prostate cancer (PCa) is not definitely known. The aim of the present study was to investigate the relationship between CTP parameters and histopathological features of PCa tissue, using a sector-wise approach. MATERIAL AND METHODS: Fifty-one patients with biopsy-proven PCa underwent prospectively a CTP scan prior to radical prostatectomy. Blood flow (BF), mean blood volume (BV) and mean transit time (MTT) were calculated, with the prostate being divided into eight sectors...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28715578/adverse-pathologic-findings-for-men-electing-immediate-radical-prostatectomy-defining-a-favorable-intermediate-risk-group
#6
Hiten D Patel, Jeffrey J Tosoian, H Ballentine Carter, Jonathan I Epstein
Importance: Active surveillance is recommended for patients with very low-risk (VLR) and low-risk (LR) prostate cancer. Despite controversy, recent clinical guidelines state surveillance may be considered for men with low-volume intermediate-risk (LVIR) disease. Objective: To compare rates of adverse pathologic findings among VLR, LR, and LVIR men electing immediate radical prostatectomy and evaluate criteria to define if a favorable intermediate-risk group minimizing risk exists...
July 13, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28712962/fenestrated-endograft-as-a-new-perspective-for-the-treatment-of-infra-renal-abdominal-aortic-aneurysm-with-a-congenital-pelvic-kidney-a-case-report-and-review-of-literature
#7
Barun Majumder, Anisha H Parera, Neil Browning, Mark MacGregor, Alex Chapman
The coexistence of Abdominal Aortic Aneurysm (AAA) and Congenital Pelvic Kidney (CPK) is infrequent. Various treatment modalities have been reported in literature for treatment of the above condition. We report a complete endovascular modality for the treatment of this association, especially for high-risk patients. Only one such treatment has been reported before. Compared to this previously reported case, we would like to share our experience with additional prototype testing, prior to surgery which provided us with more detailed information about the planning and deployment of the branched endograft...
July 13, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28712889/the-adjustable-transobturator-male-system-in-stress-urinary-incontinence-after-transurethral-resection-of-the-prostate
#8
Alexander Friedl, Jenifer Schneeweiss, Kathrin Stangl, Sandra Mühlstädt, Roman Zachoval, Stephan Hruby, Therese Gründler, Danijel Kivaranovic, Paolo Fornara, Lukas Lusuardi, Clemens Brössner
Objective To investigate the efficacy and safety of the adjustable transobturator male system (ATOMS) in males with stress urinary incontinence (SUI) after transurethral resection of the prostate (TURP). Materials and methods From a large international prospectively administrated ATOMS-register we identified 49 patients with an ATOMS device due to persistent SUI after TURP. For evaluation males were divided into standard TURP (sTURP) and palliative/post radiation TURP (pTURP). Baseline and follow-up measurements included continence parameters, urodynamics, quality of life surveys (PGI-I, ICIQ-SF) and pain ratings...
July 13, 2017: Urology
https://www.readbyqxmd.com/read/28710845/chitosan-membranes-application-on-the-prostatic-neurovascular-bundles-following-robot-assisted-radical-prostatectomy-a-phase-ii-study
#9
F Porpiglia, R Bertolo, C Fiori, M Manfredi, S De Cillis, S Geuna
OBJECTIVE: To evaluate the feasibility and the safety of the application of chitosan membranes on the neuro-vascular bundles after nerve-sparing Robot-Assisted Radical Prostatectomy (RARP). The secondary aim of the study was to report preliminary data and more particularly potency recovery data. MATERIALS AND METHODS: Single-center, single-arm prospective study. Enrolment from July 2015 to September 2016 of all patients with localized prostate cancer scheduled for RARP with IIEF-5 score > 17 after San Luigi Gonzaga Hospital Ethics Committee (Orbassano) approval (80/2015) and patient's acceptance...
July 15, 2017: BJU International
https://www.readbyqxmd.com/read/28710616/are-we-underestimating-the-rates-of-incontinence-after-prostate-cancer-treatment-results-from-nhanes
#10
Michael Daugherty, Raju Chelluri, Gennady Bratslavsky, Timothy Byler
PURPOSE: Local therapy for prostate cancer (PCa) includes radical prostatectomy (RP) and radiotherapy (XRT), both of which share a complication of urinary incontinence. Post-treatment incontinence has been reported to occur 6-69%, yet no truly patient-centered report has been compiled. We evaluated patient-reported incontinence rates and bother scores after treatment for prostate cancer. METHODS: The NHANES database was queried for all men who reported a diagnosis and treatment of PCa from 2001 to 2010...
July 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28709888/biopsy-detected-gleason-pattern-5-is-associated-with-recurrence-metastasis-and-mortality-in-a-cohort-of-men-with-high-risk-prostate-cancer
#11
Sean P Stroup, Daniel M Moreira, Zinan Chen, Lauren Howard, Jonathan H Berger, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane, Stephen J Freedland
PURPOSE: To evaluate the relative risk of biochemical recurrence (BCR), metastasis, and death from prostate cancer contributed by biopsy Gleason pattern 5 among high-risk men with Gleason 8-10 disease in the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. PATIENTS AND METHODS: Men with biopsy Gleason sum 8-10 prostate cancer treated with radical prostatectomy were evaluated. The cohort was divided: Gleason 4+4 vs. those with any pattern 5 (i.e., Gleason 3+5, 5+3, 4+5, 5+4, and 5+5)...
July 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28709851/waves-of-change-national-trends-in-surgical-management-of-male-stress-incontinence
#12
Susan MacDonald, Marc Colaco, Ryan Terlecki
OBJECTIVE: To determine the national trend in surgical management of male stress urinary incontinence (SUI) in the context of the rate of radical prostatectomy (RP) as reported by a national database. Traditionally the artificial urinary sphincter (AUS) has been the gold standard of surgical management, but the male sling represents a newer and popular alternative. Refinements in prostate surgery may reduce the incidence and degree of subsequent SUI. MATERIALS AND METHODS: A retrospective cross sectional analysis was performed using the National Inpatient Survey (NIS) database, which captures discharge data from inpatient and overnight admissions...
July 11, 2017: Urology
https://www.readbyqxmd.com/read/28707361/effect-of-climatic-parameters-on-acute-urinary-retention-incidence
#13
Kwang Suk Lee, Kyo Chul Koo, Seung Hwan Lee, Kang Su Cho, Chang-Hee Hong, Byung Ha Chung
OBJECTIVES: We investigated the effect of daily climatic parameters on spontaneous acute urinary retention (sAUR) and evaluated the risk factors for refractory/recurrent AUR. METHODS: A total of 4194 patients older than 40 years were diagnosed with AUR in the emergency department at Gangnam Severance Hospital, Seoul, from January 2007 to May 2016. To evaluate climatic parameters at sAUR onset, we included individuals living in the area around the hospital. We excluded patients with fever, who did not return to the hospital after the AUR episode or with AUR occurring within 2 weeks following admission for surgery or chemotherapy...
July 13, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28705708/perineural-invasion-by-prostate-cancer-on-mr-us-fusion-targeted-biopsy-is-associated-with-extraprostatic-extension-and-early-biochemical-recurrence-after-radical-prostatectomy
#14
Matthew Truong, Soroush Rais-Bahrami, Jeffrey W Nix, Edward M Messing, Hiroshi Miyamoto, Jennifer B Gordetsky
In recent years, multiparametric magnetic resonance imaging (MRI) and MR/ultrasound (US) fusion targeted biopsy (TB) have become more widely adopted to aid in prostate cancer (PCa) detection. Previously, TB has been found to increase the yield of clinically significant PCa and is more likely to sample the index tumor compared to traditional 12-core extended sextant biopsies. Currently the prognostic significance of perineural invasion (PNI) when identified on TB (PNI-TB) is unknown. We identified 95 men at two tertiary referral centers who underwent TB followed by radical prostatectomy between January 2014 and January 2017...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28702986/electromagnetic-field-in-control-tissue-regeneration-pelvic-pain-neuro-inflammation-and-modulation-of-non-neuronal-cells
#15
S E Aragona, G Mereghetti, G Gianazza, A Salsa, G Gianazza, J Lotti, A Vosa, T Lotti, E Canavesi
In scientific literature, magnetic fields are used both in basic science and clinical research. They are often used to treat pain and neuro-inflammation disorders thanks to their influence on cellular responses. Our project was born from the regenerative support that we wanted to give to those diseases characterized by neuro-inflammation, nerve lesion, muscles and tissues disorders that can transform the symptom (e.g. neuropathic pelvic pain) in disease. In this study, we examined the action of pulsed electromagnetic fields (PEMFs) on skin lesion regeneration and the repetitive trans-pelvic magnetic stimulation (rTPMS) on patients affected by incontinence and post-surgical problems, sexual dysfunction, and pelvic pain...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702364/robotic-assisted-common-sheath-ureteroneocystostomy-of-an-injured-ectopic-ureter-diagnosed-in-the-acute-post-operative-setting-after-robotic-assisted-radical-prostatectomy
#16
Matthew Rohloff, Cody Christensen, Thomas Maatman
Radical prostatectomies are one of the most commonly performed operations for the robotic urologist. When a rare anatomic anomaly leads to an unrecognized intraoperative injury, standard postoperative management becomes complicated. We present the case of a patient with an iatrogenic injury to an ectopic ureter that under went a robotic assisted common sheath ureteroneocystostomy three days post robotic assisted radical prostatectomy.
September 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28701587/prostate-cancer-diagnosis-using-epigenetic-biomarkers-3d-high-content-imaging-and-probabilistic-cell-by-cell-classifiers
#17
Darko Stefanovski, George Tang, Kolja Wawrowsky, Raymond C Boston, Nils Lambrecht, Jian Tajbakhsh
BACKGROUND: Prostate cancer (PCa) management can benefit from novel concepts/biomarkers for reducing the current 20-30% chance of false-negative diagnosis with standard histopathology of biopsied tissue. METHOD: We explored the potential of selected epigenetic markers in combination with validated histopathological markers, 3D high-content imaging, cell-by-cell analysis, and probabilistic classification in generating novel detailed maps of biomarker heterogeneity in patient tissues, and PCa diagnosis...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28701134/robotic-prostatectomy-took-off-despite-a-lack-of-evidence-and-risks-of-inequity
#18
Mark Frydenberg, Robert Frank A Gardiner
No abstract text is available yet for this article.
July 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28701133/robotic-prostatectomy-took-off-despite-a-lack-of-evidence-and-risks-of-inequity
#19
Katrina Hutchison, Drew Carter, Jane Johnson
No abstract text is available yet for this article.
July 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28700844/follow-up-of-prostatectomy-versus-observation-for-early-prostate-cancer
#20
Timothy J Wilt, Karen M Jones, Michael J Barry, Gerald L Andriole, Daniel Culkin, Thomas Wheeler, William J Aronson, Michael K Brawer
BACKGROUND: We previously found no significant differences in mortality between men who underwent surgery for localized prostate cancer and those who were treated with observation only. Uncertainty persists regarding nonfatal health outcomes and long-term mortality. METHODS: From November 1994 through January 2002, we randomly assigned 731 men with localized prostate cancer to radical prostatectomy or observation. We extended follow-up through August 2014 for our primary outcome, all-cause mortality, and the main secondary outcome, prostate-cancer mortality...
July 13, 2017: New England Journal of Medicine
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