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https://www.readbyqxmd.com/read/29053886/a-historical-perspective-and-evolution-of-the-treatment-of-male-urinary-incontinence
#1
Julio T Chong, Vannita Simma-Chiang
AIMS: To describe the historical changes from antiquity until present in the presentation and treatment of male urinary incontinence. METHODS: A literature review of PubMed articles in English pertaining to male incontinence was performed. RESULTS: Male urinary incontinence was first mentioned in Egyptian manuscripts in 1500 B.C. In 1564, Ambroise Pare designed portable urinals for incontinent males. Wilhem Hildanus created the first condom catheter with pig bladder in the 1600s and was also credited with fashioning the first penile clamp...
October 20, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29053402/what-are-we-missing-false-negative-cancers-at-multiparametric-mr-imaging-of-the-prostate
#2
Samuel Borofsky, Arvin K George, Sonia Gaur, Marcelino Bernardo, Matthew D Greer, Francesca V Mertan, Myles Taffel, Vanesa Moreno, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
Purpose To characterize clinically important prostate cancers missed at multiparametric (MP) magnetic resonance (MR) imaging. Materials and Methods The local institutional review board approved this HIPAA-compliant retrospective single-center study, which included 100 consecutive patients who had undergone MP MR imaging and subsequent radical prostatectomy. A genitourinary pathologist blinded to MP MR findings outlined prostate cancers on whole-mount pathology slices. Two readers correlated mapped lesions with reports of prospectively read MP MR images...
October 20, 2017: Radiology
https://www.readbyqxmd.com/read/29052761/does-surgical-delay-for-radical-prostatectomy-affect-biochemical-recurrence-a-retrospective-analysis-from-a-canadian-cohort
#3
Marc Zanaty, Mansour Alnazari, Khaled Ajib, Kelsey Lawson, Mounsif Azizi, Emad Rajih, Abdullah Alenizi, Pierre-Alain Hueber, Côme Tolmier, Malek Meskawi, Fred Saad, Raisa S Pompe, Pierre I Karakiewicz, Assaad El-Hakim, Kevin C Zorn
AIM: We sought to explore the impact of surgical wait time (SWT) to robot-assisted radical prostatectomy (RARP) on biochemical recurrence (BCR). METHOD: Retrospective review of a prospectively collected database between 2006 and 2015 was conducted on all RARP cases. SWT was defined as period from prostate biopsy to surgery. Primary outcome was the impact on BCR, which was defined as two consecutive PSA ≥ 0.2 ng/dl, or salvage external beam radiation therapy and/or salvage androgen deprivation therapy...
October 20, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29051001/episode-based-payment-variation-for-urological-cancer-surgery
#4
Chad Ellimoottil, Jonathan Li, Zaojun Ye, James M Dupree, Hye Sung Min, Deborah Kaye, Lindsey A Herrel, David C Miller
OBJECTIVE: To investigate payment variation for three common urological cancer surgeries and evaluate the potential for applying bundled payment programs to these procedures. METHODS: Using 2008-2011 Surveillance, Epidemiology, and End Results-Medicare linked data, we identified all beneficiaries aged greater than 65 years who underwent cystectomy, prostatectomy, or nephrectomy for cancer. Total episode payments were determined by aggregating hospital, professional, and post-acute care claims from the index surgical hospitalization through 90 days post-discharge...
October 16, 2017: Urology
https://www.readbyqxmd.com/read/29049492/association-of-hsd3b1-genotype-with-response-to-androgen-deprivation-therapy-for-biochemical-recurrence-after-radiotherapy-for-localized-prostate-cancer
#5
Jason W D Hearn, Wanling Xie, Mari Nakabayashi, Nima Almassi, Chad A Reichard, Mark Pomerantz, Philip W Kantoff, Nima Sharifi
Importance: The variant HSD3B1 (1245C) allele enhances dihydrotestosterone synthesis and predicts resistance to androgen-deprivation therapy (ADT) for biochemically recurrent prostate cancer after prostatectomy and for metastatic disease. Whether this is true after radiotherapy is unknown. Objective: To determine whether the HSD3B1 (1245C) allele predicts worse clinical outcomes from ADT for biochemical recurrence after radiotherapy. Design, Setting, and Participants: The Prostate Clinical Research Information System at Dana-Farber Cancer Institute was used to identify the study cohort, which included men treated with ADT for biochemical recurrence after primary radiotherapy between 1996 and 2013...
October 12, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29049468/nationwide-variation-in-rates-of-thyroidectomy-among-us-medicare-beneficiaries
#6
David O Francis, Gregory Randolph, Louise Davies
Importance: Research on variation in rates of procedures across otherwise similar geographic regions provides vital insight into practice patterns. It reveals the degree of consensus on how a particular condition is managed, shows areas where access to care may be inadequate, and other areas where the population may be receiving inappropriately high levels of care. Objective: To test the hypothesis that rates of thyroid surgery vary across US geographic regions...
October 12, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29048202/editorial-comment-for-zhang-et-al-end-2017-0095-or-r1
#7
Peter John Gilling
Since HoLEP was first described 20 years ago[1] there have been an increasing number of energy sources and techniques described to endoscopically enucleate the prostatic adenoma for BPH management [2]. Robotic-assisted laparoscopic techniques have developed in parallel, largely driven by Radical Prostatectomy for prostate cancer treatment, but recently applied to simple prostatectomy for BPH [3]. Both HoLEP and RASP are most compelling when applied to large prostates (>80g) when procedures such as TURP and Vaporization become less justifiable on both safety and efficacy grounds...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29045266/travel-distance-as-a-barrier-to-receipt-of-adjuvant-radiation-therapy-after-radical-prostatectomy
#8
David D Yang, Vinayak Muralidhar, Brandon A Mahal, Clair J Beard, Kent W Mouw, Neil E Martin, Peter F Orio, Martin T King, Paul L Nguyen
OBJECTIVES: Following radical prostatectomy (RP), adjuvant radiation therapy (RT) decreases biochemical recurrence and potentially improves metastasis-free and overall survival for patients with high-risk pathologic features. Since adjuvant RT typically occurs daily over several weeks, the logistical challenges of extensive traveling may be a significant barrier to its use. We examined the association between distance to treatment facility and use of adjuvant RT. MATERIALS AND METHODS: We identified 97,568 patients in the National Cancer Database diagnosed from 2004 through 2011 with cT1-4N0-xM0-x prostate cancer and found to have high-risk pathologic features (pT3-4 stage and/or positive surgical margins) at RP...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045185/apparent-diffusion-coefficient-values-of-prostate-cancer-comparison-of-2d-and-3d-rois
#9
Tsutomu Tamada, Chenchan Huang, Justin M Ream, Myles Taffel, Samir S Taneja, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study was to compare the reproducibility and diagnostic performance of 2D and 3D ROIs for prostate apparent diffusion coefficient (ADC) measurements. MATERIALS AND METHODS: The study included 56 patients with prostate cancer undergoing 3-T MRI including DWI (b = 50 and 1000 s/mm(2)) before radical prostatectomy. Histologic findings from prostatectomy specimens were reviewed to denote each patient's dominant tumor and a benign region with visually decreased ADC...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29042125/survival-outcomes-of-men-with-lymph-node-positive-prostate-cancer-after-radical-prostatectomy-a-comparative-analysis-of-different-postoperative-management-strategies
#10
Karim A Touijer, Robert Jeffery Karnes, Niccolo Passoni, Daniel D Sjoberg, Melissa Assel, Nicola Fossati, Giorgio Gandaglia, James A Eastham, Peter T Scardino, Andrew Vickers, Cesare Cozzarini, Francesco Montorsi, Alberto Briganti
BACKGROUND: Optimal management of patients with lymph node metastasis (LNM) after radical prostatectomy (RP) remains undefined. OBJECTIVE: We evaluated the association between three different management strategies and survival in prostate cancer with LNM after RP. DESIGN, SETTING, AND PARTICIPANTS: We analyzed data of 1338 patients with LNM after RP from three tertiary care centers. Three hundred and eighty-seven patients (28%) were observed, 676 (49%) received lifelong adjuvant androgen deprivation therapy (ADT), and 325 (23%) received adjuvant external beam radiation therapy (EBRT) and ADT...
October 14, 2017: European Urology
https://www.readbyqxmd.com/read/29039897/biochemical-recurrence-after-radical-prostatectomy-what-does-it-mean
#11
Rafael Tourinho-Barbosa, Victor Srougi, Igor Nunes-Silva, Mohammed Baghdadi, Gregory Rembeyo, Sophie S Eiffel, Eric Barret, Francois Rozet, Marc Galiano, Xavier Cathelineau, Rafael Sanchez-Salas
BACKGROUND: Radical prostatectomy (RP) has been used as the main primary treatment for prostate cancer (PCa) for many years with excellent oncologic results. However, approximately 20-40% of those patients has failed to RP and presented biochemical recurrence (BCR). Prostatic specific antigen (PSA) has been the pivotal tool for recurrence diagnosis, but there is no consensus about the best PSA threshold to define BCR until this moment. The natural history of BCR after surgical procedure is highly variable, but it is important to distinguish biochemical and clinical recurrence and to find the correct timing to start multimodal treatment strategy...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29039893/open-radical-prostatectomy-reproducing-robot-assisted-radical-prostatectomy-involving-antegrade-nerve-sparing-and-continuous-anastomosis
#12
Se Yun Kwon, Jun Nyung Lee, Yun-Sok Ha, Seock Hwan Choi, Tae-Hwan Kim, Tae Gyun Kwon
PURPOSE: To present modified RRP using the same method as RALP and compare its surgical outcomes with RALP. MATERIALS AND METHODS: Demographics, perioperative and functional outcomes of the 322 patients that underwent RRP (N=99) or RALP (N=223) at our institution from January 2011 through June 2013 were evaluated retrospectively. Postoperative incontinence and erectile dysfunction are involved functional outcomes. During the modified procedure, the bladder neck was dissected first as for RALP...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29037965/prostate-cancer-specific-pet-radiotracers-a-review-on-the-clinical-utility-in-recurrent-disease
#13
Jaden D Evans, Krishan R Jethwa, Piet Ost, Scott Williams, Eugene D Kwon, Val J Lowe, Brian J Davis
Prostate cancer-specific positron emission tomography (pcPET) has been shown to detect sites of disease recurrence at serum prostate-specific antigen (PSA) levels that are lower than those levels detected by conventional imaging. Commonly used pcPET radiotracers in the setting of biochemical recurrence are reviewed including carbon 11/fludeoxyglucose 18 (F-18) choline, gallium 68/F-18 prostate-specific membrane antigen (PSMA), and F-18 fluciclovine. Review of the literature generally favors PSMA-based agents for the detection of recurrence as a function of low PSA levels...
July 20, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29037803/prognostic-significance-and-biopsy-characteristics-of-prostate-cancer-with-seminal-vesicle-invasion-on-radical-prostatectomy-a-nationwide-population-based-study
#14
Anna Kristiansen, Linda Drevin, Brett Delahunt, Hemamali Samaratunga, David Robinson, Ingela Franck Lissbrant, Pär Stattin, Lars Egevad
The objective of this study was to evaluate the prognostic significance of seminal vesicle invasion (SVI, pT3b) compared with extraprostatic extension (EPE) alone (pT3a) after radical prostatectomy, and to correlate pre-operative biopsy pathology with SVI and EPE. The National Prostate Cancer Register includes all prostate cancers diagnosed in Sweden. We analysed 4063 cases with stage category pT3a and 1371 cases with pT3b at radical prostatectomy between 2000 and 2012. Associations between pT3a and pT3b and progression were evaluated and adjusted for year, age, biopsy grade and s-PSA...
October 13, 2017: Pathology
https://www.readbyqxmd.com/read/29034236/prognostic-value-of-the-new-prostate-cancer-international-society-of-urological-pathology-grade-groups
#15
Anne Offermann, Silke Hohensteiner, Christiane Kuempers, Julika Ribbat-Idel, Felix Schneider, Finn Becker, Marie Christine Hupe, Stefan Duensing, Axel S Merseburger, Jutta Kirfel, Markus Reischl, Verena Lubczyk, Rainer Kuefer, Sven Perner
Gleason grading is the best independent predictor for prostate cancer (PCa) progression. Recently, a new PCa grading system has been introduced by the International Society of Urological Pathology (ISUP) and is recommended by the World Health Organization (WHO). Following studies observed more accurate and simplified grade stratification of the new system. Aim of this study was to compare the prognostic value of the new grade groups compared to the former Gleason Grading and to determine whether re-definition of Gleason Pattern 4 might reduce upgrading from prostate biopsy to radical prostatectomy (RP) specimen...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29033190/3d-modelling-of-radical-prostatectomy-specimens-developing-a-method-to-quantify-tumor-morphometry-for-prostate-cancer-risk-prediction
#16
Marcus C Hovens, Kevin Lo, Michael Kerger, John Pedersen, Timothy Nottle, Natalie Kurganovs, Andrew Ryan, Justin S Peters, Daniel Moon, Anthony J Costello, Niall M Corcoran, Matthew K H Hong
Prostate cancer displays a wide spectrum of clinical behaviour from biological indolence to rapidly lethal disease, but we remain unable to accurately predict an individual tumor's future clinical course at an early curable stage. Beyond basic dimensions and volume calculations, tumor morphometry is an area that has received little attention, as it requires the analysis of the prostate gland and tumor foci in three-dimensions. Previous efforts to generate three-dimensional prostate models have required specialised graphics units and focused on the spatial distribution of tumors for optimisation of biopsy strategies rather than to generate novel morphometric variables such as tumor surface area...
September 27, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29032582/national-cohort-study-comparing-severe-medium-term-urinary-complications-following-radical-prostatectomy-robot-assisted-versus-laparoscopic-versus-retropubic-open-radical-prostatectomy
#17
A Sujenthiran, J Nossiter, M Parry, S C Charman, A Aggarwal, H Payne, P Dasgupta, N W Clarke, J van der Meulen, P Cathcart
OBJECTIVES: Despite the rapid adoption of robot-assisted radical prostatectomy (RARP), there is little evidence about the occurrence of medium-term urinary complications with this type of surgery compared to laparoscopic (LRP) or retropubic open radical prostatectomy (ORP). The aim of this study was to evaluate the occurrence of severe urinary complications within two years of surgery in men undergoing RARP, LRP or ORP. PATIENTS AND METHODS: Population-based cohort study of men who underwent RARP (n=4,947), LRP (n= 5,479), or ORP (n=6,873) between 2008 and 2012 in the English National Health Service (NHS) using national cancer registry records linked to Hospital Episodes Statistics - an administrative database of admissions to NHS hospitals...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/29032394/clinical-performance-of-68-ga-psma-11-pet-mri-for-the-detection-of-recurrent-prostate-cancer-following-radical-prostatectomy
#18
Benedikt Kranzbühler, Hannes Nagel, Anton S Becker, Julian Müller, Martin Huellner, Paul Stolzmann, Urs Muehlematter, Matthias Guckenberger, Philipp A Kaufmann, Daniel Eberli, Irene A Burger
PURPOSE: Sensitive visualization of recurrent prostate cancer foci is a challenge in patients with early biochemical recurrence (EBR). The recently established (68)Ga-PSMA-11 PET/CT has significantly improved the detection rate with published values of up to 55% for patients with a serum PSA concentration between 0.2-0.5 ng/mL. The increased soft tissue contrast in the pelvis using simultaneous (68)Ga-PSMA-11 PET/MRI might further improve the detection rate in patients with EBR and low PSA values over PET/CT...
October 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29032296/most-gleason-8-biopsies-are-downgraded-on-prostatectomy-does-4-4-7
#19
Ted Gansler, Stacey Fedewa, Robert Qi, Chun Chieh Lin, Ahmedin Jemal, Judd W Moul
PURPOSE: Non-representative biopsy sampling of prostate cancers with a biopsy Gleason score of 8 can adversely influence decisions regarding androgen deprivation among men receiving primary radiation therapy. The frequency of and factors associated with downgrading of Gleason 8 biopsies at prostatectomy are not well known. MATERIALS AND METHODS: Records from the National Cancer Database (a hospital-based registry in the United States) of 72,556 men with prostate cancer diagnosed 2010-2013, including 5,474 with Gleason 8 biopsies and no other high progression-risk criteria (per National Comprehensive Cancer Network guidelines)...
October 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29032238/psa-density-is-a-good-predictor-of-upstaging-and-upgrading-according-to-the-new-grading-system-the-keys-we-are-seeking-may-be-already-in-our-pocket
#20
Aldo Brassetti, Riccardo Lombardo, Paolo Emiliozzi, Antonio Cardi, De Vico Antonio, Iannello Antonio, Scapellato Aldo, Riga Tommaso, Pansadoro Alberto, D'Elia Gianluca
OBJECTIVES: To analyse the performance of Prostate specific antigen density (PSAD) as a predictor of upstaging and Prognostic Grade Group (PGG) upgrading. METHODS: we retrospectively evaluated data on men with prostate PCa treated with robotic radical prostatectomy (RALP) at our center in 2014-2015. Preoperative PSAD was calculated. Bioptic and pathologic PGGs were also considered in the analysis. We defined upgrading any increase in PGG after RALP; upstaging was the pathological diagnosis of a pT≥3a PCa clinically unsuspected...
October 12, 2017: Urology
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