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https://www.readbyqxmd.com/read/29232796/-four-cases-of-bacteremia-caused-by-helicobacter-cinaedi-in-the-urological-ward-at-about-the-same-time
#1
Yoshiki Hiyama, Satoshi Takahashi, Naotaka Nishiyama, Mami Nakae, Satoshi Fujii, Masaaki Shinagawa, Naoya Masumori
Here we report the outbreak of bacteremia caused by Helicobacter cinaedi (H. cinaedi) in the urology ward. Case 1 was a man in his seventies with prostate cancer. Bacteremia caused by H. cinaedi developed 6 days after robot-assisted radical prostatectomy. Case 2 was a man in his sixties with small cell carcinoma of the prostate. Bacteremia developed at 5 days of docetaxel therapy. Case 3 was a man in his fifties with left renal pelvis carcinoma. Bacteremia developed 3 days after laparoscopic left nephroureterectomy...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29232271/robotic-surgery-in-urology-facts-and-reality-what-are-the-real-advantages-of-robotic-approaches-for-prostate-cancer-patients
#2
Guillaume Ploussard
PURPOSE OF REVIEW: Despite the worldwile increasing use of robotic assistance for oncology surgery, no level 1 evidence-based benefit favoring robot-assisted radical prostatectomy (RARP) versus pure laparoscopic or open approaches has been demonstrated. We aimed to perform an update of the available evidence by evaluating most recent 2016-2017 data. RECENT FINDINGS: Population-based and prospective nonrandomized studies and one phase III randomised trial have been recently published...
December 9, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29232270/novel-focal-therapy-treatment-options-for-prostate-cancer
#3
Ryan P Werntz, Scott E Eggener
PURPOSE OF REVIEW: Examine and discuss novel focal therapy treatment options for prostate cancer. RECENT FINDINGS: With the widespread adoption of mpMRI-guided biopsies for prostate cancer, use of image-guided treatment of prostate cancer has increased. Focal therapies leading to partial gland ablation such as partial prostatectomy, focal laser ablation, irreversible electroporation, vascular targeted photodynamic therapy, and focal radiofrequency ablation have emerged and begun to be properly evaluated...
December 9, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29232247/salivary-gland-activity-obscures-mandibular-metastasis-of-prostate-carcinoma-on-68ga-prostate-specific-membrane-antigen-pet
#4
Thabo Lengana, Ismaheel Lawal, Tebatso Boshomane, Kehinde Ololade, Florette Reyneke, Chimbabantiu Kaoma, Neo Mokgoro, Mariza Vorster, Mike Sathekge
We report a case of a 65-year-old man with prostate cancer; his treatment history included radical prostatectomy followed by radiation therapy and subsequent androgen deprivation therapy for more than 5 years. He currently presented with a history of rising prostate-specific antigen and complained of jaw aches. Ga-prostate-specific membrane antigen PET/CT study performed for suspected biochemical recurrence demonstrated vertebral lesions and lesion in his jaw. Subsequent biopsy of jaw lesion demonstrated prostate cancer metastases...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29230586/comparison-of-the-diagnostic-efficacy-and-perioperative-outcomes-of-limited-versus-extended-pelvic-lymphadenectomy-during-robot-assisted-radical-prostatectomy-a-multi-institutional-retrospective-study-in-japan
#5
Shuichi Morizane, Masashi Honda, Satoshi Fukasawa, Atsushi Komaru, Junichi Inokuchi, Masatoshi Eto, Masaki Shimbo, Kazunori Hattori, Yoshiaki Kawano, Atsushi Takenaka
BACKGROUND: We conducted a retrospective study to compare the perioperative course and lymph node (LN) counts of patients undergoing limited pelvic lymphadenectomy (lPLND) or extended pelvic lymphadenectomy (ePLND) during robot-assisted radical prostatectomy in an initial Japanese series. METHODS: The cohort included 1333 patients who underwent either lPLND (n = 902) or ePLND (n = 431) during robot-assisted radical prostatectomy at five institutions in Japan...
December 11, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29230008/positive-margin-length-and-highest-gleason-grade-of-tumor-at-the-margin-predict-for-biochemical-recurrence-after-radical-prostatectomy-in-patients-with-organ-confined-prostate-cancer
#6
Brian F Chapin, Jenny N Nguyen, Mary F Achim, Neema Navai, Stephen B Williams, Ina N Prokhorova, Xuemei Wang, Elsa M Li Ning Tapia, John W Davis, Patricia Troncoso
BACKGROUND: To evaluate the pathologic features after radical prostatectomy to determine if the length of positive surgical margin (PSM) and the highest Gleason grade within the tumor at the PSM could risk stratify patients for biochemical recurrence (BCR). METHODS: We performed a retrospective, matched, cohort study to identify patients with pathologically organ-confined (pT2) tumors and negative nodes (pN0/Nx), receiving no adjuvant therapy. Specimens underwent single pathologist review...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29230007/elevated-preoperative-neutrophil-lymphocyte-ratio-predicts-upgrading-at-radical-prostatectomy
#7
Mehmet Özsoy, Marco Moschini, Harun Fajkovic, Francesco Soria, Christian Seitz, Tobias Klatte, Kilian Gust, Alberto Briganti, Pierre I Karakiewicz, Morgan Roupret, Gero Kramer, Shahrokh F Shariat
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a widely used, representative marker of systemic inflammatory response within the body. NLR can be calculated from simple, inexpensive peripheral blood samples. High NLR is a negative prognostic factor in a variety of malignancies including urological tumors. In this study, we aim to assess the prognostic value of preoperative neutrophil- lymphocyte ratio (NLR) in patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa)...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29229583/integrative-genomic-analysis-of-coincident-cancer-foci-implicates-ctnnb1-and-pten-alterations-in-ductal-prostate-cancer
#8
Marc Gillard, Justin Lack, Andrea Pontier, Divya Gandla, David Hatcher, Adam G Sowalsky, Jose Rodriguez-Nieves, Donald Vander Griend, Gladell Paner, David VanderWeele
BACKGROUND: Ductal adenocarcinoma of the prostate is an aggressive subtype, with high rates of biochemical recurrence and overall poor prognosis. It is frequently found coincident with conventional acinar adenocarcinoma. The genomic features driving evolution to its ductal histology and the biology associated with its poor prognosis remain unknown. OBJECTIVE: To characterize genomic features distinguishing ductal adenocarcinoma from coincident acinar adenocarcinoma foci from the same patient...
December 8, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29229176/use-of-concomitant-androgen-deprivation-therapy-in-patients-treated-with-early-salvage-radiotherapy-for-biochemical-recurrence-after-radical-prostatectomy-long-term-results-from-a-large-multi-institutional-series
#9
Giorgio Gandaglia, Nicola Fossati, R Jeffrey Karnes, Stephen A Boorjian, Michele Colicchia, Alberto Bossi, Thomas Seisen, Cesare Cozzarini, Nadia Di Muzio, Barbara Noris Chiorda, Emanuele Zaffuto, Thomas Wiegel, Shahrokh F Shariat, Gregor Goldner, Steven Joniau, Antonino Battaglia, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hendrick Van Poppel, Francesco Montorsi, Alberto Briganti
BACKGROUND: Hormonal manipulation concomitant to salvage radiotherapy (SRT) given for biochemical recurrence (BCR) after radical prostatectomy (RP) improved outcomes in two randomized trials. However, neither of these studies focused on men treated at low prostate-specific antigen (PSA) levels. OBJECTIVE: To test if the impact of androgen deprivation therapy (ADT) on metastasis in patients undergoing early SRT varies according to prostate cancer (PCa) features. DESIGN, SETTING, AND PARTICIPANTS: A total of 525 patients received SRT at PSA levels ≤2ng/ml...
December 8, 2017: European Urology
https://www.readbyqxmd.com/read/29228751/comparisons-of-health-related-quality-of-life-among-surgery-and-radiotherapy-for-localized-prostate-cancer-a-systematic-review-and-meta-analysis
#10
Cheng Chen, Zhen Chen, Kun Wang, Linkun Hu, Renfang Xu, Xiaozhou He
The objective of this study is to compare health-related quality of life (QOL) outcomes between radical prostatectomy (RP) and external beam radiation therapy (EBRT) for localized prostate cancer. PubMed, EMBASE, the Cochrane Library and Web of Science (to July 2017) were searched. Pooled analysis of each domain-specific score was calculated in relevant studies, and its change with follow-up time was explored by sub-group analysis. A total of six studies containing 4423 patients were included. Men underwent RP was associated with worse urinary and sexual domain score than EBRT (standardized mean difference (SMD) = -0...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228232/external-validation-of-two-web-based-postoperative-nomograms-predicting-the-probability-of-early-biochemical-recurrence-after-radical-prostatectomy-a-retrospective-cohort-study
#11
Kei Yoneda, Takanobu Utsumi, Takatoshi Somoto, Ken Wakai, Ryo Oka, Takumi Endo, Masashi Yano, Naoto Kamiya, Nobuyuki Hiruta, Hiroyoshi Suzuki
The present study aimed to validate and compare the predictive accuracies of the Memorial Sloan Kettering Cancer Center (MSKCC) and Johns Hopkins University (JHU) web-based postoperative nomograms for predicting early biochemical recurrence (BCR) after radical prostatectomy (RP) and to analyze clinicopathological factors to predict early BCR after RP using our dataset. The c-index was 0.72 (95% confidence (CI): 0.61-0.83) for the MSKCC nomogram and 0.71 (95% CI: 0.61-0.81) for the and JHU nomogram, demonstrating fair performance in the Japanese population...
December 8, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29226351/candidate-diagnostic-mirnas-that-can-detect-cancer-in-prostate-biopsy
#12
Agnieszka Paziewska, Michal Mikula, Michalina Dabrowska, Maria Kulecka, Krzysztof Goryca, Artur Antoniewicz, Jakub Dobruch, Andrzej Borowka, Piotr Rutkowski, Jerzy Ostrowski
BACKGROUND: While histopathological evaluation remains the gold standard for diagnosis of prostate cancer (PCa), sampling errors remain a frequent problem; therefore, use of tissue biomarkers that can distinguish between benign and malignant prostate disease is a potentially beneficial diagnostic strategy. METHODS: Deep sequencing of the miRNA transcriptome of 14 benign prostatic hyperplasia (BPH) and 60 cancerous and non-cancerous prostate samples extracted from 34 cancer-bearing prostates removed by prostatectomy was performed; of the latter 60 samples, 16, 21, and 23 samples contained <10%, >30%, and no dysplastic cells, respectively...
December 11, 2017: Prostate
https://www.readbyqxmd.com/read/29225060/functional-recovery-oncologic-outcomes-and-postoperative-complications-12-months-following-robot-assisted-radical-prostatectomy-follow-up-of-an-evidence-based-analysis-comparing-the-retzius-sparing-and-standard-approaches
#13
Mani Menon, Deepansh Dalela, Marcus Jamil, Mireya Diaz, Christopher Tallman, Firas Abdollah, Akshay Sood, Linda Lehtola, David Miller, Wooju Jeong
PURPOSE: To report 1-year update of functional (urinary and sexual) recovery, oncological outcomes, and postoperative complications in patients who completed a randomized controlled trial comparing posterior (Retzius-sparing) with anterior robot-assisted radical prostatectomy (RARP). MATERIAL AND METHODS: One-hundred twenty patients with clinically low-intermediate risk prostate cancer (PCa) were randomized to undergo posterior (n=60) or anterior RARP (n=60) by a single surgical team at an academic institution...
December 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29225057/comparison-of-pathological-and-oncologic-outcomes-in-favorable-risk-gs-3-4-and-low-risk-gs6-prostate-cancer-considerations-for-active-surveillance
#14
Derek J Gearman, Alessandro Morlacco, John C Cheville, Laureano J Rangel, R Jeffrey Karnes
PURPOSE: Recent NCCN guidelines report that patients with biopsy GS 3+4/GG2 but otherwise favorable features as active surveillance (AS) candidates. However, little is known about their long-term outcomes compared to low-risk GS6/GG1 group. This study aims to clarify the risk of adverse features and oncologic outcomes for surgically-treated favorable GG2 vs GG1 patients. MATERIAL AND METHODS: Our prospectively maintained RP database was queried for all patients with biopsy GG1 or GG2 PCa who otherwise fulfilled the NCCN "low risk" definition (PSA < 10 ng/ml, cT≤2a) and underwent radical prostatectomy (RP) from 1987 to 2014 (n = 8095)...
December 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29224914/nodal-metastases-at-radical-prostatectomy-more-aggressive-disease-warrants-consideration-of-multimodal-treatment
#15
EDITORIAL
Scott Eggener
No abstract text is available yet for this article.
December 7, 2017: European Urology
https://www.readbyqxmd.com/read/29224177/thinking-about-one-s-own-death-after-prostate-cancer-diagnosis
#16
Thordis K Thorsteinsdottir, Heiddis Valdimarsdottir, Johan Stranne, Ulrica Wilderäng, Eva Haglind, Gunnar Steineck
BACKGROUND: Prostate-cancer diagnosis increases the risk for psychiatric morbidity and suicide. Thoughts about one's own death could indicate need for psychiatric care among men with localized prostate cancer. We studied the prevalence and predictors of thoughts about own death among men with prostate cancer. METHODS: Of the 3930 men in the prospective, multi-centre LAPPRO-trial, having radical prostatectomy, 3154 (80%) answered two study-specific questionnaires, before and three months after surgery...
December 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29223469/oncological-and-functional-outcomes-of-elderly-men-treated-with-hifu-vs-minimally-invasive-radical-prostatectomy-a-propensity-score-analysis
#17
Paolo Capogrosso, Eric Barret, Rafael Sanchez-Salas, Igor Nunes-Silva, François Rozet, Marc Galiano, Eugenio Ventimiglia, Alberto Briganti, Andrea Salonia, Francesco Montorsi, Xavier Cathelineau
AIM: To assess outcomes of whole gland high-intensity focused ultrasound (HIFU) as compared with minimally-invasive radical prostatectomy (MIRP) in elderly patients. MATERIALS & METHODS: Patients aged ≥70 years with, cT1-cT2 disease, biopsy Gleason score (GS) 3 + 3 or 3 + 4 and preoperative PSA ≤10 ng/mL were submitted to either whole-gland HIFU or MIRP. Propensity-score matching analysis was performed to ensure the baseline equivalence of groups. Follow-up visits were routinely performed assessing PSA and urinary function according to the International Continence Score (ICS) and the International Prostatic Symptoms Score (IPSS) questionnaires...
December 1, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29221663/-long-term-outcomes-of-prostate-cancer-patients-with-lymph-nodes-metastasis-after-radical-prostatectomy-and-pelvic-lymph-node-dissection
#18
S De Vergie, N Gaschignard, M Baron, J Branchereau, F Luyckx, T Butel, M-A Perrouin-Verbe, O Bouchot, J Rigaud
INTRODUCTION: The aim of this study was to evaluate biochemical recurrence-free survival (RFS) and to identify useful predictors of such survival in localized prostate cancer patients (cN0) and pelvic lymph node metastasis (pN+) treated with radical prostatectomy and pelvic lymph node dissection. PATIENTS AND METHODS: This multicenter and retrospective study, assessed overall survival (OS), cancer specific survival (CSS) and biochemical recurrence-free survival (RFS), between January 2005 until December 2010 with 5 years of distance...
December 5, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29219284/does-a-previous-prostate-biopsy-related-acute-bacterial-prostatitis-affect-the-results-of-radical-prostatectomy
#19
Hakan Türk, Sitki Ün, Erkan Arslan, Ferruh Zorlu
OBJECTIVE: To The standard technique for obtaining a histologic diagnosis of prostatic carcinomas is transrectal ultrasound guided prostate biopsy. Acute prostatitis which might develop after prostate biopsy can cause periprostatic inflammation and fibrosis. In this study, we performed a retrospective review of our database to determine whether ABP history might affect the outcome of RP. MATERIALS AND METHODS: 441 RP patients who were operated in our clinic from 2002 to 2014 were included in our study group...
December 11, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29217354/prostate-magnetic-resonance-imaging-provides-limited-incremental-value-over-the-memorial-sloan-kettering-cancer-center-pre-radical-prostatectomy-nomogram
#20
John K Weaver, Eric H Kim, Joel M Vetter, Anup Shetty, Robert L Grubb, Seth A Strope, Gerald L Andriole
OBJECTIVES: To examine the incremental value of prostate MRI when used in combination with the currently available preoperative risk stratification tool the Memorial Sloan Kettering Cancer Center Pre-Radical Prostatectomy Nomogram (MSKCC). METHODS: We reviewed our institutional database of prostate MRI performed prior to radical prostatectomy between December 2014 and March 2016 (n=236). We generated a logistic regression model based on observed final pathology results and the MSKCC nomogram predictions for organ confined disease, extracapsular extension (ECE), seminal vesicle invasion (SVI), and lymph node (LN) involvement ('MSKCC Only')...
December 4, 2017: Urology
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