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https://www.readbyqxmd.com/read/28945062/early-recanalization-of-veins-in-patients-with-dvt-treated-with-rivaroxaban-do-we-need-to-move-from-bedside-to-bench-again
#1
Eduardo Ramacciotti, Giuliano Giova Volpiani, Ronaldo Dávila, Valeria C Resende Aguiar, Jawed Fareed
Rivaroxaban is one of the direct non-vitamin K antagonists (DOACs) that is globally approved for single drug approach to treat venous thromboembolism (VTE). Its usage is growing quickly, given the practicality of single daily dose, no need for monitoring and a better safety profile compared with that of vitamin K antagonists (VKA). As real world experience with rivaroxaban accumulates, isolated reports regarding its ability to promote earlier and more intense venous recanalization compared with VKA treatment have been published...
September 22, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28945049/-standardization-of-names-in-prescriptions-of-traditional-chinese-medicines
#2
Chao-Feng Li, Yu-Jun Zhang, Dong-He Fan, Meng-Jie Zhang, Xue Bai, Wen-Hua Yang, Shu-Ya Qi, Zhi-Jie Zhang, Chun-Miao Xue, Liu-Ying Mao, Jun-Ling Cao
Chinese medicine prescriptions are a type of medical documents written by doctors after they understand the patients' conditions for syndrome differentiation. Chinese medicine prescriptions are also the basis for pharmacy personnel to dispense medicines and guide patients to use drugs. It has the legal, technical and economic significances. Chinese medicine prescriptions contain such information of names, quantity and usage. Whether the names of drugs in Chinese medicine prescriptions are standardized or not is directly related to the safety and efficacy of the drugs...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945045/-real-world-analysis-to-explore-clinical-features-of-shenxiong-glucose-injection-combined-with-other-medications
#3
Gui-Qian Wang, Yan-Ming Xie, Huan Liu, Yin Zhang, Ping-Ping Jia, Yan Zhuang
To explore the real world clinical medication and combination characteristics of Shenxiong glucose injection. The basic information of patients with Shenxiong glucose injection, traditional Chinese and western medicine diagnosis information, doctor advice information and laboratory test information from the hospital information system(HIS) of 19 tertiary hospitals in China. Apriori algorithm was adopted to establish the models, and Clementine 12.0 was used for correlation analysis to analyze the real world clinical medication and combination characteristics of Shenxiong glucose injection...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944983/oral-prolonged-release-oxycodone-naloxone-for-managing-pain-and-opioid-induced-constipation-a-review-of-the-evidence
#4
REVIEW
Bart J Morlion, Stefan A Mueller-Lissner, Renato Vellucci, Wojciech Leppert, Benoît C Coffin, Sara L Dickerson, Tony O'Brien
BACKGROUND: Opioids provide effective relief from moderate-to-severe pain and should be prescribed as part of a multifaceted approach to pain management when other treatments have failed. Fixed-dose oxycodone/naloxone prolonged-release tablets (OXN PR) were designed to address the opioid class effect of opioid-induced constipation (OIC) by combining the analgesic efficacy of oxycodone with the opioid receptor antagonist, naloxone, which has negligible systemic availability when administered orally...
September 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28944979/dosimetric-validation-of-monaco-treatment-planning-system-on-an-elekta-versahd-linear-accelerator
#5
Ganesh Narayanasamy, Daniel L Saenz, Dewayne Defoor, Niko Papanikolaou, Sotirios Stathakis
The purpose of this study is to perform dosimetric validation of Monaco treatment planning system version 5.1. The Elekta VersaHD linear accelerator with high dose rate flattening filter-free photon modes and electron energies was used in this study. The dosimetric output of the new Agility head combined with the FFF photon modes warranted this investigation into the dosimetric accuracy prior to clinical usage. A model of the VersaHD linac was created in Monaco TPS by Elekta using commissioned beam data including percent depth dose curves, beam profiles, and output factors...
September 25, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28944945/safety-and-efficacy-of-ventriculostomy-procedures-under-dual-antiplatelet-therapy-in-patients-treated-with-stent-assisted-coiling-in-subarachnoid-hemorrhage
#6
Soner Civi, Cagatay Andic, Ozgur Kardes, Halil İbrahim Suner, Emre Durdag, Ozlem Ozmete, Kadir Tufan
AIM: Stent assisted coilling (SAC) is an alternative in the treatment of ruptured aneurysms. Stenting requires the use of dual antiplatelet agents. Hydrocephaly is a complication of subarachnoid hemorrhage (SAH) requiring ventriculostomy. Antiplatelet treatment reveal a risk of hemorrhage in ventriculostomy. Anti-aggregant effect starts at least four hours after the initial doses of treatment. However, in many studies, ventriculostomy was performed before antiplatelet treatment and the hemorrhagic complications were related to the procedure...
July 16, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944738/an-industry-update-the-latest-developments-in-therapeutic-delivery
#7
Oliver C Steinbach
The present industry update covers the period 1-30 June 2017, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. The combination of drug and devices such as improved, safer injectables (see various market reports, companies Adamis and Baxter), patches (Microdermis) and (nano)carriers are moving increasingly from the R&D stage into clinical trials and toward the market. This addresses increased safety and effectiveness requirements, limiting physico-chemical properties of active ingredients, cost-effectiveness and patient comfort through ease of use...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944732/patient-centered-drug-approval-the-role-of-patient-advocacy-in-the-drug-approval-process
#8
T Joseph Mattingly, Linda Simoni-Wastila
Recent approval of eteplirsen for Duchenne muscular dystrophy (DMD), a rare disease with few treatment alternatives, has reignited the debate over the U.S. drug approval process. The evolution of legal and regulatory restrictions to the marketing and sale of pharmaceuticals has spanned more than a century, and throughout this history, patient advocacy has played a significant role. Scientific evidence from clinical trials serves as the foundation for drug approval, but the patient voice has become increasingly influential...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944694/tissue-plasminogen-activator-based-nanothrombolysis-for-ischemic-stroke
#9
Shan Liu, Xiaozhou Feng, Rong Jin, Guohong Li
Thrombolysis with intravenous tissue plasminogen activator (tPA) is the only FDA approved treatment for patients with acute ischemic stroke, but its use is limited by narrow therapeutic window, selective efficacy, and hemorrhagic complication. In the past two decades, extensive efforts have been undertaken to extend its therapeutic time window and explore alternative thrombolytic agents, but both show little progress. Nanotechnology has emerged as a promising strategy to improve the efficacy and safety of tPA...
September 23, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28944688/treatment-of-lichen-planopilaris-methotrexate-or-cyclosporine-a-therapy
#10
Emel Bulbul Baskan, Serkan Yazici
BACKGROUND: Because of irreversible outcome of the lichen planopilaris(LPP), systemic therapy should be used in early inflammatory stages of the disease, without allowing the irreversible scar formation and permanent hair loss. OBJECTIVE: We assessed the efficacy and safety of methotrexate(MTX) and cyclosporine A (CsA) in the management of recalcitrant, extensive LPP and compared their efficacy and safety profile. METHODS: We retrospectively analyzed the 16 LPP cases treated with either CsA or MTX therapy...
September 25, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28944613/propensity-score-matched-all-comers-population-treated-with-ultra-thin-strut-bare-metal-and-sirolimus-probucol-coated-drug-eluting-stents-of-identical-stent-architecture
#11
Florian Krackhardt, Mohd Ali Rosli, Matthias Leschke, André Schneider, Christian Sperling, Tay Mok Heang, Maxime Pons, Pedro Jerónimo Sousa, Behrouz Kherad, Matthias Waliszewski
OBJECTIVE: The objective of this study was to compare the safety and efficacy of a polymer-free sirolimus coated, ultrathin strut drug eluting stent (PF-SES) to its uncoated bare-metal stent (BMS) platform of identical stent architecture. BACKGROUND: Recently published randomized trials comparing BMS to DES with a focus on shortened dual-antiplatelet therapy reported incidences of stent thrombosis (ST) and bleeding complications (LEADERS FREE) in favor of drug eluting stents (DES)...
September 25, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28944572/sizing-of-patent-ductus-arteriosus-in-adults-for-transcatheter-closure-using-the-balloon-pull-through-technique
#12
Nabil A Shafi, Gagan D Singh, Thomas W Smith, Jason H Rogers
OBJECTIVES: To describe a novel balloon sizing technique used during adult transcatheter patent ductus arteriosus (PDA) closure. In addition, to determine the clinical and procedural outcomes in six patients who underwent PDA balloon sizing with subsequent deployment of a PDA occluder device. BACKGROUND: Transcatheter PDA closure in adults has excellent safety and procedural outcomes. However, PDA sizing in adults can be challenging due to variable defect size, high flow state, or anatomical complexity...
September 25, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28944519/a-15-year-overview-of-increasing-tramadol-utilisation-and-associated-mortality-and-the-impact-of-tramadol-classification-in-the-united-kingdom
#13
Teng-Chou Chen, Li-Chia Chen, Roger David Knaggs
PURPOSE: This study aimed to develop hypotheses to explain the increasing tramadol utilisation, evaluate the impact of tramadol classification, and explore the trend between tramadol utilisation and related deaths in the United Kingdom. METHODS: This cross-sectional study used individual patient data, the Clinical Practice Research Datalink from 1993 to 2015, to calculate monthly defined daily dose (DDD)/1000 registrants, monthly prevalence and incidence of tramadol users, annual supply days, and mean daily dose of tramadol...
September 24, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28944397/chronic-myeloid-leukemia-the-promise-of-tyrosine-kinase-inhibitor-discontinuation
#14
REVIEW
Ravi Kishore Narra, Kathryn E Flynn, Ehab Atallah
Some believe that tyrosine kinase inhibitor (TKI) therapy is as close to perfect as it gets in oncologic therapy. Patients diagnosed with chronic myeloid leukemia (CML) are treated with a daily oral therapy, through which most achieve remission. TKI therapy is not associated with classic chemotherapy side effects, and most patients are able to resume their normal activities of daily living. Moreover, recent data has demonstrated that CML does not affect the life expectancy of patients whose disease is well controlled with a TKI...
September 25, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28944206/comparison-of-fda-safety-and-efficacy-data-for-kamra-and-raindrop-corneal-inlays
#15
Majid Moshirfar, Jordan D Desautels, Ryan T Wallace, Nicholas Koen, Phillip C Hoopes
AIM: To provide a side-by-side analysis of the summary of safety and effectiveness data (SSED) submitted to the FDA for the KAMRA and Raindrop corneal inlays for the correction of presbyopia. METHODS: SSED reports submitted to the FDA for KAMRA and Raindrop were compared with respect to loss of corrected distance visual acuity (CDVA), adverse event rates, induction of astigmatism, retention of contrast sensitivity, stability of manifest refractive spherical equivalent (MRSE), and achieved monocular uncorrected near visual acuity (UNVA) at 24mo...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944205/clinical-outcomes-of-small-incision-lenticule-extraction-versus-femtosecond-laser-assisted-lasik-for-myopia-a-meta-analysis
#16
Huan Yan, Li-Yan Gong, Wei Huang, Yan-Li Peng
AIM: To evaluate the possible differences in visual quality between small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK) for myopia. METHODS: A Meta-analysis was performed. Patients were from previously reported comparative studies treated with SMILE versus FS-LASIK. The PubMed, EMBASE, Cochrane, Web of Science and Chinese databases (i.e. WANFANG and CNKI) were searched in Nov. of 2016 using RevMan 5.1 version software...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944198/long-term-outcome-of-highly-myopic-foveoschisis-treated-by-vitrectomy-with-or-without-gas-tamponade
#17
Li-Na Yun, Yi-Qiao Xing
AIM: To evaluate the long-term safety and efficacy of vitrectomy and internal limiting membrane (ILM) peeling with or without gas tamponade for highly myopic foveoschisis. METHODS: We performed an open-label, observer-blinded clinical trial of 85 patients with myopic foveoschisis between 2000 and 2012. Patients were randomly allocated to one of two groups, those who received vitrectomy and ILM peeling without gas tamponade (no-gas group) or those who with gas tamponade (gas group) and follow up at least 5y...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944196/long-term-efficacy-and-safety-of-express-implantation-for-treatment-of-open-angle-glaucoma
#18
Geun Young Lee, Chong Eun Lee, Kyoo Won Lee, Sam Seo
AIM: To compare the long-term efficacy and safety of ExPress implantation and standard trabeculectomy in patients with primary open angle glaucoma (POAG). METHODS: In this retrospective study, we compared 17 eyes treated by ExPress implantation with 23 eyes treated by trabeculectomy. Efficacy was assessed according to the relevant intraocular pressure (IOP) values and success rates during the first year of follow-up. Postoperative corneal endothelial cell loss was also compared...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944177/isolated-septal-myectomy-for-hypertrophic-obstructive-cardiomyopathy-an-update-on-the-toronto-general-hospital-experience
#19
Rachel D Vanderlaan, Anna Woo, Anthony Ralph-Edwards
BACKGROUND: Isolated septal myectomy is considered the gold standard for refractory left ventricular outflow tract (LVOT) obstruction at centers with dedicated hypertrophic obstructive cardiomyopathy (HOCM) surgeons. In this paper, we provide an update on the Toronto General Hospital (TGH) experience for isolated septal myectomy and comment on the safety and efficacy of myectomy in patients with thin basal septal thickness at our institution. METHODS: We retrospectively reviewed all patients undergoing surgical myectomy at our institution from January 2012 to August 2016...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944140/mucopolysaccharidosis-type-i-ii-and-vi-and-response-to-enzyme-replacement-therapy-results-from-a-single-center-case-series-study
#20
José Francisco da Silva Franco, Regina El Dib, Arnav Agarwal, Diogo Soares, Noala Vicensoto Moreira Milhan, Lilian Maria José Albano, Chong Ae Kim
Mucopolysaccharidoses (MPS) types I, II and VI are associated with deficiencies in alpha-L-iduronidase, iduronate-2-sulfatase and N-acetylgalactosamine-4-sulfatase, respectively, and generally involve progressive and multi-systemic clinical manifestations. Enzyme replacement therapy (ERT) appears to be reasonably well tolerated. The aim of this study was to examine clinical and diagnostic findings of a series of pediatric and adult MPS patients, and assess the safety and efficacy of ERT in children and adults with MPS type I, II and VI...
August 2017: Intractable & Rare Diseases Research
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