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Right heart failure

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https://www.readbyqxmd.com/read/29928764/inhomogeneous-down-regulation-of-i-na-underlies-piceatannol-pro-arrhythmic-mechanism-in-regional-ischemia-reperfusion
#1
Po-Cheng Chang, Yu-Chang Huang, Hui-Ling Lee, Gwo-Jyh Chang, Yen Chu, Ming-Shien Wen, Chung-Chuan Chou
BACKGROUND: Piceatannol, a grape-derived polyphenol, has been linked to pro-arrhythmic properties by aggravating inhomogeneous conduction delay in the ischemia-reperfusion (IR) zone to enhance arrhythmogenic alternans in heart failure (HF) rabbits. The underlying molecular mechanisms of piceatannol-induced conduction disturbance were unclear in this model. METHODS: HF was induced by 4-weeks rapid ventricular pacing. IR injury was induced in vivo using a protocol of left coronary artery ligation and release...
June 21, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29928642/pathophysiology-and-diagnosis-of-pulmonary-hypertension-due-to-left-heart-disease
#2
REVIEW
Athanasios Charalampopoulos, Robert Lewis, Peter Hickey, Charlotte Durrington, Charlie Elliot, Robin Condliffe, Ian Sabroe, David G Kiely
Pulmonary hypertension due to left heart disease (PH-LHD) is the most common type of pulmonary hypertension, although an accurate prevalence is challenging. PH-LHD includes PH due to systolic or diastolic left ventricular dysfunction, mitral or aortic valve disease and congenital left heart disease. In recent years a new and distinct phenotype of "combined post-capillary and pre-capillary PH," based on diastolic pulmonary gradient and pulmonary vascular resistance, has been recognized. The roles of right ventricular dysfunction and pulmonary vascular compliance in PH-LHD have also been elucidated recently and they appear to have significant clinical implications...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29928010/association-between-right-ventricle-two-and-three-dimensional-echocardiography-and-exercise-capacity-in-patients-with-reduced-left-ventricular-ejection-fraction
#3
Aleksandra Sljivic, Milena Pavlovic Kleut, Zoran Bukumiric, Vera Celic
INTRODUCTION: Echocardiography represents the most commonly performed noninvasive cardiac imaging test for patients with heart failure (HF). The aim of this study was to assess the relationship between exercise capacity parameters (peak oxygen consumption (VO2) and the minute ventilation-carbon dioxide production relationship (VE/VCO2)), two-dimensional speckle-tracking echocardiography (2D-STE) and three-dimensional echocardiography (3DE) imaging of right ventricular (RV) function in HF patients with reduced ejection fraction (EF)...
2018: PloS One
https://www.readbyqxmd.com/read/29925397/right-heart-catheterization-using-metallic-guidewires-and-low-sar-cardiovascular-magnetic-resonance-fluoroscopy-at-1-5-tesla-first-in-human-experience
#4
Adrienne E Campbell-Washburn, Toby Rogers, Annette M Stine, Jaffar M Khan, Rajiv Ramasawmy, William H Schenke, Delaney R McGuirt, Jonathan R Mazal, Laurie P Grant, Elena K Grant, Daniel A Herzka, Robert J Lederman
BACKGROUND: Cardiovascular magnetic resonance (CMR) fluoroscopy allows for simultaneous measurement of cardiac function, flow and chamber pressure during diagnostic heart catheterization. To date, commercial metallic guidewires were considered contraindicated during CMR fluoroscopy due to concerns over radiofrequency (RF)-induced heating. The inability to use metallic guidewires hampers catheter navigation in patients with challenging anatomy. Here we use low specific absorption rate (SAR) imaging from gradient echo spiral acquisitions and a commercial nitinol guidewire for CMR fluoroscopy right heart catheterization in patients...
June 21, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29925183/-analysis-on-the-factors-related-to-the-immediate-success-rate-of-radiofrequency-catheter-ablation-on-patients-with-idiopathic-right-ventricular-outflow-tract-ventricular-arrhythmia
#5
G Chen, X F Li, X H Fan, K J Zhang, F Z Wang, Y Yao
Objective: To analyze the clinical characteristics of patients with idiopathic right ventricular outflow tract (RVOT) ventricular arrhythmias (VA) and factors related to the immediate success rate of radiofrequency ablation. Methods: Patients diagnosed as idiopathic RVOT arrhythmia in Fuwai Hospital from February 2009 to January 2013 were retrospectively screened. Patients with structural heart disease or inherited arrhythmia were excluded. All patients underwent endocardial electrophysiological study and radiofrequency catheter ablation...
June 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29924941/therapeutic-targeting-of-vascular-remodeling-and-right-heart-failure-in-pah-with-hif-2%C3%AE-inhibitor
#6
Zhiyu Dai, Maggie M Zhu, Yi Peng, Narsa Machireddy, Colin E Evans, Roberto Machado, Xianming Zhang, You-Yang Zhao
RATIONALE: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive vasoconstriction and obliterative vascular remodeling that leads to right heart failure (RHF) and death. Current therapies do not target vascular remodeling and RHF, and only result in modest improvement of morbidity and mortality. OBJECTIVE: To determine whether targeting HIF-2α with a HIF-2α-selective inhibitor could reverse PAH and RHF in different rodent PAH models...
June 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29923888/human-myocardium-has-a-robust-%C3%AE-1a-subtype-adrenergic-receptor-inotropic-response
#7
Paul M L Janssen, Benjamin D Canan, Ahmet Kilic, Bryan A Whitson, Anthony J Baker
Recent studies report that a single subtype of α1-adrenergic receptor (α1-AR), the α1A-subtype, mediates robust cardioprotective effects in multiple experimental models of heart failure, suggesting that the α1A-subype is a potential therapeutic target for an agonist to treat heart failure. Moreover, we recently found that the α1A-subtype is present in human heart. The goal of this study was to assess the inotropic response mediated by the α1A-subtype in human myocardium, and to determine if the response is down-regulated in myocardium from failing human heart...
May 25, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29923339/cardiovascular-disease-in-diabetes-type-2-current-concepts
#8
REVIEW
A Rosengren
Type 2 diabetes is a major and accelerating public health challenge. Between 1980 and 2014, a period of just 35 years, the number of adults with diabetes globally is estimated to have increased from 108 million to 422 million, due not only to sharply rising obesity rates, but also to increasing population size, and longer life expectancy. The increase in numbers is due to an increasing prevalence of diabetes worldwide, increasing population size, and longer life expectancy. Overall, worldwide age-standardized adult diabetes prevalence doubled from 4...
June 20, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29922067/elevated-levels-of-vitamin-b12-in-chronic-stable-heart-failure-a-marker-for-subclinical-liver-damage-and-impaired-prognosis
#9
Onur Argan, Dilek Ural, Kurtuluş Karauzum, Serdar Bozyel, Mujdat Aktas, Irem Yilmaz Karauzum, Güliz Kozdag, Aysen Agacdiken Agir
Background: Elevated vitamin B12 is a sign for liver damage, but its significance in chronic stable heart failure (HF) is less known. The present study investigated the clinical correlates and prognostic significance of vitamin B12 levels in stable systolic HF. Methods: A total of 129 consecutive patients with HF and 50 control subjects were enrolled. Data regarding demographics, clinical signs, therapeutic and conventional echocardiographic measurements were recorded for all patients...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29922027/large-nonapical-right-ventricular-diverticulum-in-a-patient-with-atrioventricular-septal-defect
#10
Michael Weidenbach, Bardo Wannenmacher, Christian Paech, Robert Wagner
Congenital diveticula and aneurysm of the heart are rare and most often located at the apex of the left ventricle. They pose a significant risk for cardiac failure and arrhythmias. In contrast, nonapical diverticula of the right ventricle (RV) have a much more benign course. We present a child with Trisomy 21, atrioventricular septal defect, and large nonapical diverticulum of the RV that was neither addressed during surgery nor needed any medical treatment during 1-year follow-up.
May 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/29920745/evaluation-of-the-effectiveness-of-an-interactive-avatar-based-education-application-for-improving-heart-failure-patients-knowledge-and-self-care-behaviors-a-pragmatic-randomized-controlled-trial-protocol
#11
Parichat Wonggom, Huiyun DU, Robyn A Clark
AIM: The aim of this study is to evaluate the effectiveness of an avatar-based education application for improving knowledge and self-care behavior in patients with heart failure. BACKGROUND: Avatar-based technologies for supporting education are an innovative approach for patients with low literacy, low health literacy and English as a second language. The use of avatar technologies for patient education has shown benefits in improving knowledge, self-care behaviors and quality of life in chronic diseases such as cancer, diabetes and depression...
June 19, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29920539/clinical-phenotypes-and-outcomes-of-pulmonary-hypertension-due-to-left-heart-disease-role-of-the-pre-capillary-component
#12
Sergio Caravita, Andrea Faini, Sandy Carolino D'Araujo, Céline Dewachter, Laura Chomette, Antoine Bondue, Robert Naeije, Gianfranco Parati, Jean-Luc Vachiéry
BACKGROUND: In pulmonary hypertension (PH), both wedge pressure elevation (PAWP) and a precapillary component may affect right ventricular (RV) afterload. These changes may contribute to RV failure and prognosis. We aimed at describing the different haemodynamic phenotypes of patients with PH due to left heart disease (LHD) and at characterizing the impact of pulmonary haemodynamics on RV function and outcome PH-LHD. METHODS: Patients with PH-LHD were compared with treatment-naïve idiopathic/heritable pulmonary arterial hypertension (PAH, n = 35)...
2018: PloS One
https://www.readbyqxmd.com/read/29917260/does-obesity-affect-the-outcomes-in-takotsubo-cardiomyopathy-analysis-of-the-nationwide-inpatient-sample-database-2010-2014
#13
Rupak Desai, Sandeep Singh, Maryam Baikpour, Hemant Goyal, Abhijeet Dhoble, Abhishek Deshmukh, Gautam Kumar, Rajesh Sachdeva
BACKGROUND: It is well known that obesity can lead to increased oxidative stress, which is one of the proposed mechanisms in the etiopathogenesis of Takotsubo Cardiomyopathy (TCM). However, it is unknown if the presence of obesity affects the outcomes in patients with TCM. METHODS: We queried the National Inpatient Sample database from 2010-2014 to identify adult patients who admitted with a principal diagnosis of TCM with and without obesity. We compared the categorical and continuous variables by Pearson's chi-square and Student's t-test respectively in propensity-score matched cohorts...
June 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29914291/the-path-to-surgery-in-carcinoid-heart-disease-a-retrospective-study-and-a-multidisciplinary-proposal-of-a-new-algorithm
#14
Philippe Mortelmans, Marie-Christine Herregods, Filip Rega, Philippe Timmermans
BACKGROUND: Development of carcinoid heart disease (CHD) is the major negative prognostic factor in patients with the carcinoid syndrome. The only effective treatment is valve replacement. However, the selection of candidates and determination of optimal timing remain unclear. Considerable variability in local screening and treatment strategies exist. METHODS: In this single-centre study, we retrospectively analysed the diagnostic process and outcome of all CHD patients who underwent valve surgery between 2000 and 2016...
June 18, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29913923/national-guidelines-for-evaluating-pain-patients-legal-right-to-prioritised-health-care-at-multidisciplinary-pain-clinics-in-norway-implemented-2009
#15
Karen Walseth Hara, Petter Borchgrevink
Background All nations are posed with the challenge of deciding how to allocate limited health care resources. A Patients' Rights Law from 1999 gives patients in Norway with a serious health condition, for which there is efficacious and cost-effective treatment, a legal right to receive health care from the National Health Care system. Methods Recently national guidelines have been produced for implementing these legal rights within 32 fields of specialist health care. One of these fields deals with serious chronic pain conditions...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29912990/peptide-conjugated-phosphodiamidate-oligomer-mediated-exon-skipping-has-benefits-for-cardiac-function-in-mdx-and-cmah-mdx-mouse-models-of-duchenne-muscular-dystrophy
#16
Alison M Blain, Elizabeth Greally, Graham McClorey, Raquel Manzano, Corinne A Betts, Caroline Godfrey, Liz O'Donovan, Thibault Coursindel, Mike J Gait, Matthew J Wood, Guy A MacGowan, Volker W Straub
Cardiac failure is a major cause of mortality in patients with Duchenne muscular dystrophy (DMD). Antisense-mediated exon skipping has the ability to correct out-of-frame mutations in DMD to produce truncated but functional dystrophin. Traditional antisense approaches have however been limited by their poor uptake into cardiac muscle. The addition of cell-penetrating peptides to antisense molecules has increased their potency and improved their uptake into all muscles, including the heart. We have investigated the efficacy of the Peptide-conjugated phosphodiamidate morpholino oligomer (P-PMO) Pip6a-PMO, for restoration of cardiac dystrophin and functional rescue in DMD mice- the mdx mouse and the less well characterised Cmah-/-mdx mouse (which carry a human-like mutation in the mouse Cmah gene as well as a mutation in DMD)...
2018: PloS One
https://www.readbyqxmd.com/read/29911012/rupture-of-sinus-of-valsalva-aneurysm-into-left-atrium-in-a-patient-who-is-a-candidate-for-hepatic-transplantation
#17
Veysel Tosun, Necmettin Korucuk, Unal Guntekin
Sinus of valsalva aneurysm (SVA) is a rare cardiac disease. The most common complication of SVA is rupture into the right atrium or right ventricle. Rupture into the left chambers is very rare. Patients with ruptured SVA are likely to die of heart failure or endocarditis. We present a 29-year-old man who was hospitalized for hepatic transplantation with rupture of SVA. Transthoracic echocardiography and transesophageal echocardiography showed rupture of a noncoronary SVA into the left atrium. Mitral valve infective endocarditis developed and surgery was planned for the patient, but the patient died due to multiple organ dysfunction syndrome...
April 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29911007/elevated-mean-pulmonary-artery-pressure-and-right-ventricular-dysfunction-in-children-with-chronic-kidney-disease
#18
Igoche D Peter, Mustafa O Asani, Ibrahim Aliyu, Patience N Obiagwu
Background: Elevated mean pulmonary artery pressure (mPAP) and right heart failure increase mortality in patients with chronic kidney disease (CKD). Objectives: The objective of this study is to determine the prevalence of elevated mPAP in children with CKD compared with matched controls and to ascertain the relationship between elevated mPAP with right ventricular dysfunction and history of hemodialysis. Materials and Methods: A cross-sectional comparative study of mPAP and tricuspid annular plane systolic excursion of 21 children with CKD and age- and sex-matched controls asymptomatic for cardiac disease was conducted...
April 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29910054/treatment-of-sleep-disordered-breathing-in-heart-failure-impacts-cardiac-remodeling-insights-from-the-cat-hf-trial
#19
Melissa A Daubert, David J Whellan, Holger Woehrle, Gudaye Tasissa, Kevin J Anstrom, JoAnn Lindenfeld, Adam Benjafield, Amy Blase, Naresh Punjabi, Mona Fiuzat, Olaf Oldenburg, Christopher M O'Connor
BACKGROUND: Sleep-disordered breathing (SDB), including central and obstructive sleep apnea, is a marker of poor prognosis in heart failure (HF) and may worsen cardiac dysfunction over time. Treatment of SDB with adaptive servoventilation (ASV) may reverse pathologic cardiac remodeling in HF patients. METHODS: The Cardiovascular Improvements with Minute Ventilation-targeted Adaptive Servo-Ventilation Therapy in Heart Failure (CAT-HF) trial randomized patients with acute decompensated HF and confirmed SDB to either optimal medical therapy (OMT) or treatment with ASV and OMT...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909737/respirophasic-desaturation-in-multivalvar-rheumatic-heart-disease
#20
Krishna Kumar Mohanan Nair, Arun Gopalakrishnan, Ajitkumar Valaparambil
A 28-year-old lady with rheumatic heart disease presented with dyspnoea and overt right heart failure and was admitted for stabilization. She had respirophasic desaturation predominantly during inspiration. Trans-oesophageal echocardiography revealed the aetiology of the same and dictated the management strategy.
June 17, 2018: Acta Cardiologica
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