keyword
https://read.qxmd.com/read/38545743/a-meta-analysis-of-risk-factors-for-acute-kidney-injury-in-pneumonia-effectiveness-of-nursing-interventions
#1
REVIEW
Liangjuan Yuan, Arshad Mehmood, Lei Meng
INTRODUCTION: The spread of coronavirus disease 2019 (COVID-19) worldwide since November 2019 is of interest to understand its impact on various organs. COVID-19 patients experience a higher incidence of acute kidney injury (AKI) compared with non-COVID-19 patients. METHODS: A systematic literature search was conducted that covered the period from November 1, 2019 to February 28, 2021. RESULTS: The analysis incorporated a comprehensive review of 19 studies of 21 362 patients...
March 28, 2024: Therapeutic Apheresis and Dialysis
https://read.qxmd.com/read/38542410/biomarkers-in-contrast-induced-acute-kidney-injury-towards-a-new-perspective
#2
REVIEW
María Ángeles González-Nicolás, Cristian González-Guerrero, Marian Goicoechea, Lisardo Boscá, Lara Valiño-Rivas, Alberto Lázaro
Contrast-Induced Acute Kidney Injury (CI-AKI) remains a frequent iatrogenic condition since radiological procedures using intra-vascular iodinated contrast media (CM) are being widely administered for diagnostic and therapeutic purposes. Despite the improvement of the medical healthcare system worldwide, CI-AKI is still associated with direct short-term and indirect long-term outcomes including increased morbidity and mortality, especially in patients with underlying pre-existing renal function impairment, cardiovascular disease, or diabetes that could rapidly progress into Chronic Kidney Disease...
March 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541189/preoperative-age-and-its-impact-on-long-term-renal-functional-decline-after-robotic-assisted-partial-nephrectomy-insights-from-a-tertiary-referral-center
#3
JOURNAL ARTICLE
Cesare Saitta, Giuseppe Garofano, Giovanni Lughezzani, Margaret F Meagher, Kit L Yuen, Vittorio Fasulo, Pietro Diana, Alessandro Uleri, Andrea Piccolini, Stefano Mancon, Paola Arena, Federica Sordelli, Matilde Mantovani, Pier Paolo Avolio, Edoardo Beatrici, Rodolfo F Hurle, Massimo Lazzeri, Alberto Saita, Paolo Casale, Ithaar H Derweesh, Marco Paciotti, Nicolò M Buffi
Background and Objectives : to investigate the impact of age on renal function deterioration after robotic-assisted partial nephrectomy (RAPN) focusing on a decline to moderate and severe forms of chronic kidney disease (CKD). Materials and Methods : This is a single center prospective analysis of patients who underwent RAPN. The outcomes include the development of de novo CKD-S 3a [estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 )] and de novo CKD-S 3b (eGFR < 45 mL/min/1.73/m2 ). Multivariable analysis (MVA) via Cox regression identified predictors for CKD-S 3a/b...
March 11, 2024: Medicina
https://read.qxmd.com/read/38536864/sex-related-differences-in-pre-dialysis-trajectories-and-dialysis-initiation-a-french-nationwide-retrospective-study
#4
JOURNAL ARTICLE
Maxime Raffray, Louise Bourasseau, Cécile Vigneau, Cécile Couchoud, Clémence Béchade, François Glowacki, Sahar Bayat
BACKGROUND: In the last two decades, sex and gender differences have been documented in chronic kidney disease (CKD) management, including access to renal replacement therapy and its outcomes. The objectives of this study were to 1) compare the pre-dialysis healthcare utilization in men and women, and 2) examine the sex-specific factors associated with emergency dialysis start. METHODS: Adult patients with CKD who started dialysis in France in 2015 were extracted from the Renal Epidemiology and Information Network registry...
2024: PloS One
https://read.qxmd.com/read/38532586/-evaluation-of-safety-of-early-enteral-nutrition-in-patients-with-severe-intra-abdominal-infection-and-intestinal-fistulas
#5
JOURNAL ARTICLE
T Xie, C Chen, D L Yang, W Y Wang, F Chen, Y N He, P F Wang, Y S Li
Objective: To evaluate the safety of early enteral nutrition (EEN) support in patients with severe intra-abdominal infection and intestinal fistulas. Methods: This was a retrospective cohort study. We collected relevant clinical data of 204 patients with severe intra-abdominal infection and intestinal fistulas who had been managed in the No. 1 Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University between 1 January 2017 and 1 January 2020. The patients were allocated to EEN or delayed enteral nutrition (DEN) groups depending on whether enteral nutrition had been instituted within 48 hours of admission to the intensive care unit...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38531564/investigation-of-renal-perfusion-and-pathological-changes-in-patients-with-acute-kidney-disease-and-tubulointerstitial-nephritis-using-intravoxel-incoherent-motion-and-arterial-spin-labelling-mri-a-prospective-observational-study-protocol
#6
JOURNAL ARTICLE
Jiajia Liu, Rui Wang, Jianxing Qiu, Tao Su
INTRODUCTION: Acute kidney injury (AKI) is a critical condition with a complex aetiology and different outcomes, where haemodynamic dysfunction, renal hypoperfusion and inflammation serve as key contributors to its development and progression. Early and accurate diagnosis is vital for initiating targeted treatments like fluid resuscitation, vasoactive agents or steroid therapy, which are essential for improving patient outcomes. Intravoxel incoherent motion (IVIM) MRI assesses both capillary perfusion and tissue water diffusion, while arterial spin labelling (ASL) MRI measures renal blood flow without the need for contrast...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38529500/sexually-dimorphic-renal-expression-of-klotho-is-directed-by-a-kidney-specific-distal-enhancer-responsive-to-hnf1b
#7
Jakub Jankowski, Hye Kyung Lee, Chengyu Liu, Julia Wilflingseder, Lothar Hennighausen
Transcription enhancers are genomic sequences regulating common and tissue-specific genes and their disruption can contribute to human disease development and progression. Klotho , a sexually dimorphic gene specifically expressed in kidney, is well-linked to kidney dysfunction and its deletion from the mouse genome leads to premature aging and death. However, the sexually dimorphic regulation of Klotho is not understood. Here, we characterize two candidate Klotho enhancers using H3K27ac epigenetic marks and transcription factor binding and investigate their functions, individually and combined, through CRISPR-Cas9 genome engineering...
March 4, 2024: bioRxiv
https://read.qxmd.com/read/38527442/renal-progenitors-derived-from-urine-for-personalized-diagnosis-of-kidney-diseases
#8
REVIEW
Benedetta Mazzinghi, Maria Elena Melica, Laura Lasagni, Paola Romagnani, Elena Lazzeri
BACKGROUND: Chronic kidney disease affects 10% of the world population and it is associated with progression to end stage kidney disease and increased morbidity and mortality. The advent of multi-omics technologies has expanded our knowledge on the complexity of kidney diseases, revealing their frequent genetic etiology, particularly in young subjects. Genetic heterogeneity and drug screening require patient-derived disease models to establish a correct diagnosis and evaluate new potential treatments and outcome...
March 25, 2024: Kidney & Blood Pressure Research
https://read.qxmd.com/read/38525502/pyxinol-fatty-acid-ester-derivatives-j16-against-aki-by-selectively-promoting-m1-transition-to-m2c-macrophages
#9
JOURNAL ARTICLE
Yaru Wang, Changcheng Li, Jingyi Chen, Xiaoli Cui, Binghuan Wang, Yuezeng Wang, Dayu Wang, Jinping Liu, Jing Li
Acute kidney injury (AKI) is a common, multicause clinical condition that, if ignored, often progresses to chronic kidney disease (CKD) and end-stage kidney disease, with a mortality rate of 40-50%. However, there is a lack of universal treatment for AKI. Inflammation is the basic pathological change of early kidney injury, and inflammation can exacerbate AKI. Macrophages are the primary immune cells involved in the inflammatory microenvironment of kidney disease. Therefore, regulating the function of macrophages is a crucial breakthrough for the AKI intervention...
March 25, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38524235/associations-between-inflammatory-and-angiogenic-proteomic-biomarkers-and-cardiovascular-events-and-mortality-in-relation-to-kidney-function
#10
JOURNAL ARTICLE
Barbara Salzinger, Kristina Lundwall, Marie Evans, Josefin Mörtberg, Håkan Wallén, Tomas Jernberg, Thomas Kahan, Pia Lundman, Per Tornvall, David Erlinge, Bertil Lindahl, Tomasz Baron, Melinda Rezeli, Jonas Spaak, Stefan H Jacobson
BACKGROUND: The links between chronic kidney disease (CKD) and the high burden of cardiovascular disease remain unclear. We aimed to explore the association between selected inflammatory and angiogenic biomarkers, kidney function and long-term outcome in patients with an acute coronary syndrome (ACS) and to test the hypothesis that CKD status modifies this association. METHODS: A total of 1293 ACS patients hospitalized between 2008 and 2015 were followed until 31 December 2017...
March 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38523999/filling-in-the-gaps-ethylene-glycol-poisoning-presenting-with-isolated-lactate-and-osmolar-gaps
#11
Caden Quintanilla, Justin Panthappattu, Davood Hosseini, Karan Omidvari
Ethylene glycol (EG) is an organic compound used in antifreeze. In 2020 alone, there were 5,277 EG exposures, with only 617 reported as intentional ingestions. Therefore, encountering EG toxicity is rare; however, it is essential to identify it promptly based on a focused history, exam, and rapid identification of commonly associated EG-induced metabolic derangements. If the diagnosis is not made within 12 hours of ingestion or exposure, severe morbidity and mortality can occur. Previous reports of EG poisoning have occurred in the setting of a lactate gap (LG) and osmolar gap (OG); however, they also had commonly associated findings of EG toxicity such as high anion gap acidosis (HAGMA), acute kidney injury (AKI), hypocalcemia, calcium oxalate stones, and suggestive histories of EG ingestion...
February 2024: Curēus
https://read.qxmd.com/read/38523983/rapid-progression-of-aortitis-caused-by-methicillin-sensitive-staphylococcus-aureus-in-a-patient-with-pneumonia-a-case-report
#12
Hideya Itagaki, Tomoya Ooizumi, Chiho Sanada, Yoshinobu Abe, Tomoyuki Endo
Infected aortic aneurysm is a rare but fatal disease that occurs through various mechanisms. In this report, we describe the case of a patient who was hospitalized for acute pneumonia and developed an infected aortic aneurysm in the descending aorta during the hospitalization. A 73-year-old Japanese man presented to the emergency department with a chief complaint of fever. He had a history of chronic renal failure due to nephrosclerosis and was on regular hemodialysis three times a week. The patient presented with an elevated inflammatory response, anemia, and low platelet counts after various tests...
February 2024: Curēus
https://read.qxmd.com/read/38522954/the-association-between-monocyte-to-high-density-lipoprotein-cholesterol-ratio-and-chronic-kidney-disease-in-a-chinese-adult-population-a-cross-sectional-study
#13
JOURNAL ARTICLE
Lingling Xu, Dongling Li, Zongwei Song, Jin Liu, Yang Zhou, Junwei Yang, Ping Wen
BACKGROUND: Monocyte to high-density lipoprotein cholesterol ratio (MHR) was confirmed as a novel inflammatory marker and strongly associated with the risk of several diseases. This study aimed to investigate the relationship between MHR and chronic kidney disease (CKD) in a Chinese adult population. METHODS: In this cross-sectional study, 232,775 community-dwelling adults in Binhai who completed health checkups in 2021 were enrolled. Participants were categorized based on the MHR quartiles...
December 2024: Renal Failure
https://read.qxmd.com/read/38522819/effect-of-modified-citrus-pectin-on-galectin-3-inhibition-in-cisplatin-induced-cardiac-and-renal-toxicity
#14
JOURNAL ARTICLE
Diego D Santos, Nycole M Belote, Gisela R S Sasso, Rebeca D Correia-Silva, Paulo C Franco, Artur Francisco da Silva Neto, Fernanda T Borges, Lila M Oyama, Cristiane D Gil
This study evaluated the effect of pharmacological inhibition of galectin 3 (Gal-3) with modified citrus pectin (MCP) on the heart and kidney in a model of cisplatin-induced acute toxicity. Male Wistar rats were divided into four groups (n = 6/group): SHAM, which received sterile saline intraperitoneally (i.p.) for three days; CIS, which received cisplatin i.p. (10mg/kg/day) for three days; MCP, which received MCP orally (100mg/kg/day) for seven days, followed by sterile saline i.p. for three days; MCP+CIS, which received MCP orally for seven days followed by cisplatin i...
March 22, 2024: Toxicology
https://read.qxmd.com/read/38521286/serotonin-regulation-of-mitochondria-in-kidney-diseases
#15
REVIEW
Kevin Hurtado, Natalie E Scholpa, Jennifer G Schnellmann, Rick G Schnellmann
Serotonin, while conventionally recognized as a neurotransmitter in the CNS, has recently gained attention for its role in the kidney. Specifically, serotonin is not only synthesized in the kidney, but it also regulates glomerular function, vascular resistance, and mitochondrial homeostasis. Because of serotonin's importance to mitochondrial health, this review is focused on the role of serotonin and its receptors in mitochondrial function in the context of acute kidney injury, chronic kidney disease, and diabetic kidney disease, all of which are characterized by mitochondrial dysfunction and none of which has approved pharmacological treatments...
March 21, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38516472/nephrological-detrimental-impacts-resulting-from-novel-immunotherapy-drugs-used-in-the-treatment-of-cancer-a-systematic-review
#16
REVIEW
Amisha Jaiswal, Kainaat Shergill, Kusalik Boppana, Naiela E Almansouri, Saloni Bakkannavar, Youmna Faheem, Tuheen Sankar Nath
The most recent advancements in cancer therapy center on efficiently and conveniently enhancing a patient's natural immune system. Immune checkpoint inhibitors (ICIs) are antibodies that target cytotoxic thymus (T) lymphocyte antigen-4 (CTLA-4) and its receptor. They function by stimulating T-cell activity against malignancies. Immune-related adverse events (irAEs) are a distinct class of inflammatory side effects that are specific to a given organ. Antineoplastic medications can impact any part of the kidney, leading to the development of proteinuria, hypertension, electrolyte abnormalities, glomerulonephritis, and both acute and chronic interstitial nephritis...
February 2024: Curēus
https://read.qxmd.com/read/38516106/risk-of-acute-kidney-injury-in-critically-ill-patients-with-covid-19-compared-with-seasonal-influenza-a-retrospective-cohort-study
#17
JOURNAL ARTICLE
Pauline Yeung Ng, April Ip, Andrew Kei-Yan Ng, Simon Wai-Ching Sin, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Desmond Yat-Hin Yap
BACKGROUND: The SARS-CoV-2 virus can bind to angiotensin-converting enzyme 2 receptors on host renal cells and may cause acute kidney injury (AKI). The comparative risks of AKI in patients severely ill with COVID-19 and influenza A have not been examined. METHODS: This is a retrospective cohort study including patients with positive PCR results for SARS-CoV-2 or influenza A virus admitted to the intensive care units (ICUs) of 15 public hospitals in Hong Kong between 1st January 2013 and 30th April 2023...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38512840/acute-kidney-injury-in-hospitalized-children-with-proteinuria-a-multicenter-retrospective-analysis
#18
JOURNAL ARTICLE
Katelyn H Baggett, Tomas Manghi, Vonn Walter, Neal J Thomas, Michael A Freeman, Conrad Krawiec
BACKGROUND AND OBJECTIVE: Acute kidney injury (AKI) is a common complication in hospitalized pediatric patients. Previous studies focused on adults found that proteinuria detected during an admission urinalysis is fit to serve as an indicator for AKI and associated clinical outcomes. The objective of this study is to evaluate if proteinuria on the first day of hospital services in hospitalized children is associated with AKI, need for renal replacement therapy, shock and/or antibiotic use, critical care services, and all-cause mortality at 30 days, hypothesizing that it is associated with these outcomes...
2024: PloS One
https://read.qxmd.com/read/38511219/parental-obesity-predisposes-offspring-to-kidney-dysfunction-and-increased-susceptibility-to-ischemia-reperfusion-injury-in-a-sex-dependent-manner
#19
JOURNAL ARTICLE
Jussara M do Carmo, John E Hall, Xuemei Dai, Nikaela Aitken, Kylie Larson, Emilio M Luna-Suarez, Zhen Wang, Ana C M Omoto, Alan Mouton, Xuan Li, Luzia N S Furukawa, Viktoria Woronik, Alexandre A da Silva
Although obesity is recognized as a risk factor for cardiorenal and metabolic diseases, the impact of parental obesity on the susceptibility of their offspring to renal injury at adulthood is unknown. We examined the impact of parental obesity on offspring kidney function, morphology, and markers of kidney damage after acute kidney injury (AKI). Offspring from normal (N) diet-fed C57BL/6J parents were fed either N (NN) or a high fat (H) diet (NH) from weaning until adulthood. Offspring from obese H diet-fed parents were fed N (HN) or H diet (HH) after weaning...
March 21, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38510762/acute-kidney-injury-in-patients-undergoing-extracorporeal-membrane-oxygenation-a-retrospective-cohort-study
#20
JOURNAL ARTICLE
Aswin Surjit, Bipi Prasannan, Jobin Abraham, Anuroop Balagopal, Vavullipathy Narayanan Unni
AIMS AND BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is a mode of extracorporeal therapy to support oxygenation of patients with severe cardiac or respiratory failure. Studies have shown that acute kidney injury (AKI) can worsen the outcome in these patients. This study aims to assess the incidence and outcome of AKI in patients on ECMO support. MATERIALS AND METHODS: This retrospective study included 64 patients who underwent ECMO for more than 24 hours...
January 2024: Indian Journal of Critical Care Medicine
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