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https://www.readbyqxmd.com/read/28500507/impact-of-severe-hematological-abnormalities-in-the-outcome-of-hospitalized-patients-with-influenza-virus-infection
#1
A Lalueza, H Trujillo, J Laureiro, B Ayuso, P Hernández-Jiménez, C Castillo, M Torres, D Folgueira, O Madrid, C Díaz-Pedroche, E Arrieta, C Arévalo, C Lumbreras
Although hematological abnormalities have been described among patients with influenza virus infection, little is known about their impact on the outcome of the patients. The aim of this study was to assess the frequency and clinical impact of severe hematological abnormalities in patients with confirmed influenza virus infection. This was an observational retrospective study including all adult patients with diagnosis of influenza virus infection hospitalized from January to May 2016 in our institution. Influenza virus infection was diagnosed by means of rRT-PCR assay performed on respiratory samples...
May 13, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28489423/is-rheumatoid-arthritis-associated-with-a-declined-immunogenicity-of-influenza-vaccination-a-systematic-review-and-meta-analysis
#2
Yafang Huang, Huili Wang, Wilson W S Tam
OBJECTIVE: To determine whether immunogenicity and safety of influenza vaccination in rheumatoid arthritis (RA) patients are significantly different from those in healthy population. METHODS: PubMed, MEDLINE, Embase, Cochrane Library and Web of Science were searched on 31 August 2016. Studies were included when they met the inclusion criteria. Two reviewers independently extracted data on study characteristics, methodological quality and outcomes. The primary outcome was seroprotection (SP) rate after immunization...
May 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28329354/clinical-significance-of-human-coronavirus-in-bronchoalveolar-lavage-samples-from-hematopoietic-cell-transplant-recipients-and-patients-with-hematologic-malignancies
#3
Chikara Ogimi, Alpana A Waghmare, Jane M Kuypers, Hu Xie, Cecilia C Yeung, Wendy M Leisenring, Sachiko Seo, Su-Mi Choi, Keith R Jerome, Janet A Englund, Michael Boeckh
Background.: The possible role of human coronavirus (HCoV) in lower respiratory tract disease (LRTD) in hematopoietic cell transplant (HCT) recipients and patients with hematologic malignancies (HM) has not been well studied. Methods.: We conducted a retrospective review of HCT/HM patients with HCoV detected in bronchoalveolar lavage (BAL). HCoV strains were identified in BAL samples using strain-specific polymerase chain reaction. Mortality rates were compared among HCT recipients with LRTD caused by HCoV, respiratory syncytial virus (RSV), influenza virus, or parainfluenza virus (PIV) by multivariable Cox regression analysis...
June 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28183847/human-rhinovirus-detection-in-the-lower-respiratory-tract-of-hematopoietic-cell-transplant-recipients-association-with-mortality
#4
Sachiko Seo, Alpana Waghmare, Emily M Scott, Hu Xie, Jane M Kuypers, Robert C Hackman, Angela P Campbell, Su-Mi Choi, Wendy M Leisenring, Keith R Jerome, Janet A Englund, Michael Boeckh
Human rhinoviruses are the most common respiratory viruses detected in patients after hematopoietic cell transplantation. Although rhinovirus appears to occasionally cause severe lower respiratory tract infection in immunocompromised patients, the clinical significance of rhinovirus detection in the lower respiratory tract remains unknown. We evaluated 697 recipients transplanted between 1993 and 2015 with rhinovirus in respiratory samples. As comparative cohorts, 273 recipients with lower respiratory tract infection caused by respiratory syncytial virus (N=117), parainfluenza virus (N=120), or influenza (N=36) were analyzed...
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28144057/respiratory-viruses-in-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#5
Parvaiz A Koul, Hyder Mir, Shabir Akram, Varsha Potdar, Mandeep S Chadha
OBJECTIVE: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) cause significant morbidity, mortality, and an inexorable decline of lung function. Data from developed countries have shown viruses to be important causes of AECOPD, but data from developing countries like India are scant. We set out to determine the contribution of viruses in the causation of hospitalized patients with AECOPD. METHODS: Twin nasopharyngeal/oropharyngeal swabs collected from 233 patients admitted with an acute AECOPD and tested for respiratory viruses including respiratory syncytial virus A and B, parainfluenza were (PIV) 1, 2, 3, and 4, human metapneumovirus (hMPV) A and B, influenza A and B, enterovirus, corona NL65, OC43, and 229E viruses, adenovirus 2 and 4, rhinovirus, and bocavirus, by duplex real time reverse-transcription polymerase chain reaction (qRT-PCR) using CDC approved primers and probes...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28120567/lower-respiratory-tract-diseases-caused-by-common-respiratory-viruses-among-stem-cell-transplantation-recipients-a-single-center-experience-in-korea
#6
Kyung Wook Hong, Su Mi Choi, Dong Gun Lee, Sung Yeon Cho, Hyo Jin Lee, Jae Ki Choi, Si Hyun Kim, Sun Hee Park, Jung Hyun Choi, Jin Hong Yoo, Jong Wook Lee
PURPOSE: To describe the incidence, clinical courses, and risk factors for mortality of lower respiratory tract diseases (LRDs) caused by common respiratory viruses (CRVs) in stem cell transplantation (SCT) recipients. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 1038 patients who received SCT between January 2007 and August 2011 at a single center in Korea. RESULTS: Seventy-one CRV-LRDs were identified in 67 (6...
March 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27885562/respiratory-syncytial-virus-and-influenza-are-the-key-viral-pathogens-in-children-2%C3%A2-years-hospitalized-with-bronchiolitis-and-pneumonia-in-islamabad-pakistan
#7
Uzma Bashir, Nadia Nisar, Yasir Arshad, Muhammad Masroor Alam, Asiya Ashraf, Hajra Sadia, Birjees Mazher Kazi, Syed Sohail Zahoor Zaidi
Pneumonia remains a leading cause of morbidity and mortality in developing countries. Comprehensive surveillance data are needed to review the prevention and control strategies. We conducted active surveillance of acute lower respiratory infections among children aged <2 years hospitalized at two hospitals of Islamabad, Pakistan. Viral etiology was determined using real-time PCR on respiratory specimens collected during March 2011-April 2012. The overall mean age was 7.83 ± 5.25 months while no statistical difference between age or sex distribution of patients with positive and negative viral etiology (p > 0...
March 2017: Archives of Virology
https://www.readbyqxmd.com/read/27833453/benign-acute-childhood-myositis-complicating-influenza-b-infection-in-a-boy-with-idiopathic-nephrotic-syndrome
#8
Piotr Skrzypczyk, Joanna Przychodzień, Małgorzata Pańczyk-Tomaszewska
INTRODUCTION: Benign acute childhood myositis (BACM) is an acute complication of an infection characterized by calf pain, limitation of lower limb mobility, an increase in serum creatine kinase, and a self-limiting course. No reports of BACM in children with idiopathic nephrotic syndrome (INS) can be found in the literature. CASE REPORT: A 5-year-old boy with steroid-sensitive INS presented with fever, leg pain, and problems with walking. Physical examination showed pharyngeal erythema, preserved movements in all joints, and weakness of leg muscles...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27725476/clinical-features-of-acute-and-fulminant-myocarditis-in-children%C3%A3-2nd-nationwide-survey-by-japanese-society-of-pediatric-cardiology-and-cardiac-surgery
#9
MULTICENTER STUDY
Hiroyuki Matsuura, Fukiko Ichida, Tsutomu Saji, Shunichi Ogawa, Kenji Waki, Masahide Kaneko, Masahiro Tahara, Takashi Soga, Yasuo Ono, Satoshi Yasukochi
BACKGROUND: The 1st nationwide survey by the Japanese Society of Pediatric Cardiology and Cardiac Surgery of acute or fulminant myocarditis (AMC/FMC) in children revealed that the survival rate of FMC was only 51.6%. The 2nd nationwide survey was performed to evaluate the recent outcomes of pediatric myocarditis.Methods and Results:Questionnaires regarding patients aged ≤18 years with AMC/FMC during the period from January 2006 to December 2011 were mailed. A total of 221 cases (age 6...
October 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27696462/an-early-innate-response-underlies-severe-influenza-induced-exacerbations-of-asthma-in-a-novel-steroid-insensitive-and-anti-il-5-responsive-mouse-model
#10
L Ravanetti, A Dijkhuis, Y S Sabogal Pineros, S M Bal, B S Dierdorp, T Dekker, A Logiantara, I M Adcock, N L Rao, L Boon, G Villetti, P J Sterk, F Facchinetti, R Lutter
BACKGROUND: Acute worsening of asthma symptoms (exacerbation) is predominantly triggered by respiratory viruses, with influenza causing the most severe exacerbations. The lack of an adequate animal model hampers mechanistic insight and the development of new therapeutics. AIM: We developed and characterized a robust, consistent, and reproducible mouse model of severe exacerbation of chronic allergic asthma. METHODS: Chronic allergic airway inflammation was induced following a house dust mite (HDM) sensitization protocol...
May 2017: Allergy
https://www.readbyqxmd.com/read/27686318/henoch-schonlein-purpura-without-typical-lesions-presenting-with-gastrointestinal-manifestations-and-kidney-involvement-following-influenza-a-case-report
#11
Chan Won Park, In Seok Lim, Sin Weon Yun, Soo Ahn Chae, Na Mi Lee, Dae Yong Yi
We report a case of Henoch-Schonlein purpura (HSP) presenting without typical skin lesion; atypical symptoms initially appeared following influenza infection. A 4-year-old girl with influenza presented with epigastric pain and vomiting. On physical examination, there was epigastric tenderness, but no other signs, such as skin rash. On the second day, she vomited blood 10 times. Ultrasonography indicated focal bowel wall thickening in the right upper quadrant. Esophagogastroduodenoscopy showed oedematous and purpuric mucosa in the gastric pylorus and duodenum...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27647011/antiviral-activities-of-compounds-from-aerial-parts-of-salvia-plebeia-r-br
#12
Sunghee Bang, Thi Kim Quy Ha, Changyeol Lee, Wei Li, Won-Keun Oh, Sang Hee Shim
ETHNOPHARMACOLOGICAL RELEVANCE: Salvia plebeia R. Br. is an edible plant widely spread in many countries. It has been used as a traditional medicine to treat common cold, flu, cough, hepatitis, hemorrhoids, etc. The purpose of the study is to explicate antiviral compounds responsible for its traditional use for the common cold or flu. MATERIALS AND METHODS: The methanolic extract of the aerial parts of S. plebeia was extracted with CHCl3, EtOAc, and n-BuOH, successively...
November 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27591118/reversible-splenial-lesion-syndrome-in-children-retrospective-study-and-summary-of-case-series
#13
REVIEW
Wen-Xiong Chen, Hong-Sheng Liu, Si-Da Yang, Si-Hui Zeng, Yuan-Yuan Gao, Zhi-Hong Du, Xiao-Jing Li, Hai-Sheng Lin, Hui-Ci Liang, Jian-Ning Mai
OBJECTIVE: To describe clinical features of reversible splenial lesion syndrome (RESLES) in children. METHODS: Retrospectively analyzed clinical features of RESLES in children and compared differences between severe and non-severe group, classified by clinical global impression-scale; summarized clinical features of children with mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) from case series. RESULTS: 16 episodes of RESLES occurring in 15 Chinese children were analyzed, with 13 episodes having MERS and 3 episodes with epilepsy...
November 2016: Brain & Development
https://www.readbyqxmd.com/read/27590634/factors-associated-with-hospitalization-for-seasonal-influenza-in-a-japanese-nonelderly-cohort
#14
Sachiko Ono, Yosuke Ono, Hiroki Matsui, Hideo Yasunaga
BACKGROUND: Nonelderly patients may require hospitalization if their symptoms of influenza are severe. However, little evidence is available about the risk factors for hospitalization for influenza. METHODS: We used a multicenter outpatient and inpatient database to obtain patients' characteristics and clinical procedures. We identified patients aged <65 years with a confirmed diagnosis of influenza between October 2013 and December 2014. We used a Cox regression model to identify the risk factors for hospitalization, using a comparison group of individuals with a confirmed diagnosis of influenza but who were not hospitalized...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27542581/-benign-acute-childhood-myositis-clinical-series-and-literature-review
#15
Felipe Cavagnaro S M, Ingrid Harwardt, Alejandra Aird G, Carmen Gloria Marambio Q
Benign acute childhood myositis (BACM) is a rare clinical condition that mainly affects pre-school and school age-children. It is usually preceded by a viral illness, particularly influenza virus infection. OBJECTIVE: To describe a cluster of BACM cases that were seen in a paediatric unit. PATIENTS AND METHODS: A retrospective series of cases that presented with a clinical picture suggestive of BACM between August and November 2012 in the paediatric emergency department of a private clinic...
August 16, 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/27505715/enterovirus-d68-in-critically-ill-children-a-comparison-with-pandemic-h1n1-influenza
#16
Suchitra Rao, Kevin Messacar, Michelle R Torok, Anne-Marie Rick, Jeffrey Holzberg, Aaron Montano, Dayanand Bagdure, Donna J Curtis, M Steven Oberste, W Allan Nix, Gina de Masellis, Christine C Robinson, Samuel R Dominguez
OBJECTIVE: In 2014, the Unites States experienced an outbreak of enterovirus D68 associated with severe respiratory illness. The clinical characteristics associated with severe illness from enterovirus D68 during this outbreak compared with those associated with the 2009 H1N1 influenza virus outbreak are unknown. DESIGN AND SETTING: In this retrospective cohort study, we characterized the clinical features of children with enterovirus D68 admitted to the PICU between August 1, 2014, and November 1, 2014, and compared them with critically ill children infected with H1N1 influenza during the pandemic admitted between May 1, 2009, and January 31, 2010...
November 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27448447/microrna-21-drives-severe-steroid-insensitive-experimental-asthma-by-amplifying-phosphoinositide-3-kinase-mediated-suppression-of-histone-deacetylase-2
#17
Richard Y Kim, Jay C Horvat, James W Pinkerton, Malcolm R Starkey, Ama T Essilfie, Jemma R Mayall, Prema M Nair, Nicole G Hansbro, Bernadette Jones, Tatt Jhong Haw, Krishna P Sunkara, Thi Hiep Nguyen, Andrew G Jarnicki, Simon Keely, Joerg Mattes, Ian M Adcock, Paul S Foster, Philip M Hansbro
BACKGROUND: Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently required, however, their development is hampered by a lack of understanding of the mechanisms of disease pathogenesis. Steroid-insensitive asthma is associated with respiratory tract infections and noneosinophilic endotypes, including neutrophilic forms of disease. However, steroid-insensitive patients with eosinophil-enriched inflammation have also been described. The mechanisms that underpin infection-induced, severe steroid-insensitive asthma can be elucidated by using mouse models of disease...
February 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27403242/pandemic-influenza-a-h1n1-in-oman-epidemiology-clinical-features-and-outcome-of-patients-admitted-to-sultan-qaboos-university-hospital-in-2009
#18
Mujahid Al-Busaidi, Khuloud Al Maamari, Badriya Al'Adawi, Fatma Ba Alawi, Adil Al-Wahaibi, Abdullah Belkhair
OBJECTIVES: Oman experienced the H1N1 pandemic in 2009 that initially started in Mexico and the United States. We present the epidemiology, clinical features, and outcome of cases admitted to Sultan Qaboos University Hospital. METHODS: We retrospectively reviewed all patients admitted with confirmed influenza A H1N1 infection from August to December 2009. The study included adults and pediatric patients. We looked at the clinical and laboratory factors associated with increased length of hospital stay...
July 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/27215504/self-reported-influenza-vaccination-and-protective-serum-antibody-titers-in-a-cohort-of-copd-patients
#19
T M Eagan, J A Hardie, Å Jul-Larsen, T B Grydeland, P S Bakke, R J Cox
BACKGROUND: COPD patients are advised vaccination against seasonal influenza, yet few studies have evaluated the protective antibody titers obtained in this patient group. AIMS: 1) To describe protective titers in COPD patients who self-reported influenza vaccination compared with vaccinated subjects without COPD and unvaccinated COPD patients, 2) analyze whether clinical parameters predicted influenza-specific antibody titers, and 3) whether antibody titers to influenza A at baseline could predict exacerbation risk or 5 years all-cause mortality...
June 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27129425/morning-vaccination-enhances-antibody-response-over-afternoon-vaccination-a-cluster-randomised-trial
#20
Joanna E Long, Mark T Drayson, Angela E Taylor, Kai M Toellner, Janet M Lord, Anna C Phillips
OBJECTIVES: Older adults are less able to produce a protective antibody response to vaccinations. One factor that contributes to this is immune ageing. Here we examined whether diurnal variations in immune responses might extend to the antibody response to vaccination. DESIGN: We utilised a cluster-randomised trial design. SETTING: 24 General Practices (GPs) across the West Midlands, UK who were assigned to morning (9-11am; 15 surgeries) or afternoon (3-5pm; 9 surgeries) vaccination times for the annual UK influenza vaccination programme...
May 23, 2016: Vaccine
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