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Oseltamivir

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https://www.readbyqxmd.com/read/28633457/an-ha-stem-antibody-medi8852-prevents-and-controls-disease-and-limits-transmission-of-pandemic-influenza-viruses
#1
C I Paules, S Lakdawala, J M McAuliffe, M Paskel, L Vogel, N L Kallewaard, Q Zhu, K Subbarao
Background: MEDI8852 is a novel MAb which neutralizes both group I and group II influenza A viruses (IAV) in vitro. We evaluated whether MEDI8852 was effective for prophylaxis and therapy against representative group I (H5N1) and group II (H7N9) pandemic IAV in mice and ferrets and could be used to block transmission of influenza H1N1pdm09 in ferrets, compared to an irrelevant control MAb R347 and oseltamivir. Results: MEDI8852 was effective for prophylaxis and treatment of H7N9 and H5N1 infection in mice, with a clear dose-dependent response and treatment with MEDI8852 24, 48 or 72 h post-infection (hpi) was superior to oseltamivir for H5N1...
June 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28612701/neuraminidase-mediated-haemagglutination-of-recent-human-influenza-a-h3n2-viruses-is-determined-by-arginine-150-flanking-the-neuraminidase-catalytic-site
#2
Ramona Mögling, Mathilde J Richard, Stefan van der Vliet, Ruud van Beek, Eefje J A Schrauwen, Monique I Spronken, Guus F Rimmelzwaan, Ron A M Fouchier
Over the last decade, an increasing proportion of circulating human influenza A(H3N2) viruses exhibited haemagglutination activity that was sensitive to neuraminidase inhibitors. This change in haemagglutination as compared to older circulating A(H3N2) viruses prompted an investigation of the underlying molecular basis. Recent human influenza A(H3N2) viruses were found to agglutinate turkey erythrocytes in a manner that could be blocked with either oseltamivir or neuraminidase-specific antisera, indicating that agglutination was driven by neuraminidase, with a low or negligible contribution of haemagglutinin...
June 13, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28607038/who-downgrades-oseltamivir-on-drugs-list-after-reviewing-evidence
#3
Zosia Kmietowicz
No abstract text is available yet for this article.
June 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28592016/-efficacy-and-safety-of-oseltamivir-in-children-with-suspected-influenza-a-multicenter-randomized-open-label-trial
#4
C H He, C Y Liu, G Y Lin, Q Peng, J Y Liao, J H Lin, T Zhang, X F Zheng, C X Lin, S J Wang, R S Chen, L Deng, Y M Chen
Objective: To evaluate the efficacy and safety of oseltamivir in the treatment of suspected influenza in children. Method: A multicenter, randomized and open-label trial was conducted among 229 individuals with suspected influenza which were collected from the clinic of 5 hospitals in Guangdong province (Guangzhou Women and Children's Medical Center, Shenzhen Baoan District Maternity and Child Care Service Center, the Second Affiliated Hospital of Shantou University Medical College, Dongguan Maternity and Child Care Service Centre, Yuexiu District Children's Hospital of Guangzhou) from April to July 2015...
June 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28577016/clinical-and-epidemiological-characterization-of-influenza-a-h1n1pdm-and-b-among-hospitalized-children-georgia-season-2010-2011
#5
A Machablishvili, D Tsereteli, Kh Zakhashvili, I Karseladze, P Imnadze
The aim of the study was to describe, analyze and compare clinical and epidemiological characteristics of laboratory confirmed influenza A(H1N1)pdm and B cases in hospitalized children during post pandemic season. Between 1st January and 1st May, 2011 retrospective observational study was conducted in M. Iashvili Children's Central Hospital. From 1028 patients with influenza like illness hospitalized at Children's Hospital 871 specimens were collected and 360 tested positive for influenza: A(H1N1)pdm - 139 and B - 221...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28571763/effect-of-target-enriched-multiplex-polymerase-chain-reaction-on-patient-outcomes-and-costs-during-the-2013-14-influenza-season
#6
A Hassoun, M D Huff, E Asis, K Chahal, A Azarbal, S Lu
The US Centers for Disease Control and Prevention recommends the initial use of rapid antigen influenza diagnostic test (RIDT) for the detection of influenza A (H1N1-09). Nasopharyngeal samples were tested from 246 patients for H1N1-09 using target-enriched multiplex polymerase chain reaction (TEM-PCR), of which 163 were additionally tested via RIDT. RIDTs had a sensitivity of 18.7% compared with TEM-PCR as the reference standard. Patients with false-negative RIDTs were withheld from 111 days of oseltamivir and 65 days of isolation...
April 21, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28557785/updated-stability-data-for-midazolam-oseltamivir-phosphate-and-propranolol-hydrochloride-in-surspend-sf-and-minoxidil-in-espumil
#7
Eli Dijkers, Valerie Nanhekhan, Astrid Thorissen
No abstract text is available yet for this article.
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28550754/linear-polysialoside-outperforms-dendritic-analogs-for-inhibition-of-influenza-virus-infection-in%C3%A2-vitro-and-in%C3%A2-vivo
#8
Sumati Bhatia, Daniel Lauster, Markus Bardua, Kai Ludwig, Stefano Angioletti-Uberti, Nicole Popp, Ute Hoffmann, Florian Paulus, Matthias Budt, Marlena Stadtmüller, Thorsten Wolff, Alf Hamann, Christoph Böttcher, Andreas Herrmann, Rainer Haag
Inhibition of influenza A virus infection by multivalent sialic acid inhibitors preventing viral hemagglutinin binding to host cells of the respiratory tract is a promising strategy. However, optimal geometry and optimal ligand presentation on multivalent scaffolds for efficient inhibition both in vitro and in vivo application are still unclear. Here, by comparing linear and dendritic polyglycerol sialosides (LPGSA and dPGSA) we identified architectural requirements and optimal ligand densities for an efficient multivalent inhibitor of influenza virus A/X31/1 (H3N2)...
May 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/28548600/a-multi-spectroscopic-and-molecular-docking-approach-to-investigate-the-interaction-of-antiviral-drug-oseltamivir-with-ct-dna
#9
Neda Hosseinpour Moghadam, Sadegh Salehzadeh, Nahid Shahabadi, Reza Golbedaghi
The possible interaction between the antiviral drug oseltamivir and calf thymus DNA at physiological pH was studied by spectrophotometry, competitive spectrofluorimetry, differential pulse voltammogram (DPV), circular dichroism spectroscopy (CD), viscosity measurements, salt effect, and computational studies. Intercalation of oseltamivir between the base pairs of DNA was shown by a sharp increase in specific viscosity of DNA and a decrease of the peak current and a positive shift in differential pulse voltammogram...
May 26, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/28540991/comparison-of-efficacy-of-intravenous-peramivir-and-oral-oseltamivir-for-the-treatment-of-influenza-systematic-review-and-meta-analysis
#10
Jonghoo Lee, Ju Hee Park, Hyeyoung Jwa, Yee Hyung Kim
PURPOSE: Peramivir is the first intravenously administered neuramidase inhibitor for immediate delivery of an effective single-dose treatment in patients with influenza. However, limited data are available on intravenous (IV) peramivir treatment compared to oral oseltamivir for these patients. MATERIALS AND METHODS: With a systematic review and meta-analysis, we compared the efficacy of IV peramivir with oral oseltamivir for treatment of patients with seasonal influenza...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28539708/assessment-of-mexican-arnica-heterotheca-inuloides-cass-and-rosemary-rosmarinus-officinalis-extracts-on-dopamine-and-selected-biomarkers-of-oxidative-stress-in-stomach-and-brain-of-salmonella-typhimurium-infected-rats
#11
David Calderón Guzmàn, Maribel Ortiz Herrera, Norma Osnaya Brizuela, Gerardo Barragàn Mejía, Ernestina Hernàndez García, Hugo Juàrez Olguín, Armando Valenzuela Peraza, Norma Labra Ruíz, Daniel Santamaría Del Angel
BACKGROUND: The effects of some natural products on dopamine (DA) and 5-hydroxyindole acetic acid (5-HIAA) in brain of infected models are still unclear. OBJECTIVE: The purpose of this study was to measure the effect of Mexican arnica/rosemary (MAR) water extract and oseltamivir on both biogenic amines and some oxidative biomarkers in the brain and stomach of young rats under infection condition. METHODS: Female Wistar rats (weight 80 g) in the presence of MAR or absence (no-MAR) were treated as follows: group 1, buffer solution (controls); oseltamivir (100 mg/kg), group 2; culture of Salmonella typhimurium (S...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28535933/anti-inflammatory-effects-of-adjunctive-macrolide-treatment-in-adults-hospitalized-with-influenza-a-randomized-controlled-trial
#12
Nelson Lee, Chun-Kwok Wong, Martin C W Chan, Esther S L Yeung, Wilson W S Tam, Owen T Y Tsang, Kin-Wing Choi, Paul K S Chan, Angela Kwok, Grace C Y Lui, Wai-Shing Leung, Irene M H Yung, Rity Y K Wong, Catherine S K Cheung, David S C Hui
INTRODUCTION: - Macrolides can ameliorate inflammation in respiratory diseases, providing clinical benefits. Data in influenza is lacking. METHOD: - A randomized, open-label, multicenter trial among adults hospitalized for laboratory-confirmed influenza was conducted. Study treatments of oseltamivir and azithromycin (500 mg/day), or oseltamivir alone, both for 5 days, were allocated at 1:1 ratio. The primary outcome was plasma cytokine/chemokine concentration change over time (Day 0-10); secondary outcomes were viral load and symptom score changes...
May 20, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28506350/-a-preliminary-study-on-the-disappearance-time-of-influenza-virus-antigen
#13
Hao-Feng Chen, Li-Li Zhang, Yi-Bing Fang, Min Chen, Chun Guo, Hong-Ling Yi, Mei-Ting Tao, Yan Li, Chu-Feng Dai
OBJECTIVE: To investigate the antigen clearance time, time to symptom disappearance, and the association between them using immunofluorescence assay for dynamic monitoring of influenza virus antigen in children with influenza. METHODS: A total of 1 063 children suspected of influenza who visited the Hunan People's Hospital from March to April, 2016 were enrolled. The influenza A/B virus antigen detection kit (immunofluorescence assay) was used for influenza virus antigen detection...
May 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28499541/sequence-analysis-of-haemagglutinin-and-neuraminidase-of-h1n1-strain-from-a-patient-coinfected-with-mycobacterium-tuberculosis
#14
Ahmed N Alghamdi, Mohammad E Mahfouz, Fahd A Hamdi, Daifullah Al Aboud, Tawfiq Z Al-Laylah, Mohammed I Alotaibi, Khalid W A Al-Thomali, Ahmed S Abdel-Moneim
The 2009 H1N1 pandemic (H1N1pdm09) was associated with a considerable influenza-related morbidity and mortality. Among the complications, Mycobacterial tuberculosis was recorded as a coinfection with influenza in rare cases. The full-length sequences of the viral haemagglutinin and neuraminidase of H1N1pdm09 influenza A virus were analyzed from a recently infected patient. The patient was chronically infected with Mycobacterium tuberculosis. Molecular modelling and in-silico docking of the virus, and other selected strains with the drug oseltamivir were conducted and compared...
May 9, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28496342/sialylation-facilitates-self-assembly-of-3d-multicellular-prostaspheres-by-using-cyclo-rgdfk-tpp-peptide
#15
Sabah Haq, Vanessa Samuel, Fiona Haxho, Roman Akasov, Maria Leko, Sergey V Burov, Elena Markvicheva, Myron R Szewczuk
BACKGROUND: Prostaspheres-based three dimensional (3D) culture models have provided insight into prostate cancer (PCa) biology, highlighting the importance of cell-cell interactions and the extracellular matrix (EMC) in the tumor microenvironment. Although these 3D classical spheroid platforms provide a significant advance over 2D models mimicking in vivo tumors, the limitations involve no control of assembly and structure with only limited spatial or glandular organization. Here, matrix-free prostaspheres from human metastatic prostate carcinoma PC3 and DU145 cell lines and their respective gemcitabine resistant (GemR) variants were generated by using cyclic Arg-Gly-Asp-D-Phe-Lys peptide modified with 4-carboxybutyl-triphenylphosphonium bromide (cyclo-RGDfK(TPP))...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28494845/monitoring-influenza-virus-susceptibility-to-oseltamivir-using-a-new-rapid-assay-iart
#16
Larisa V Gubareva, Eric Fallows, Vasiliy P Mishin, Erin Hodges, Abdullah Brooks, John Barnes, Alicia M Fry, William Kramp, Roxanne Shively, David E Wentworth, Kristin Weidemaier, Ross Jacobson
A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as 'resistant'. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing...
May 4, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28494777/platelet-desialylation-is-a-novel-mechanism-and-a-therapeutic-target-in-thrombocytopenia-during-sepsis-an-open-label-multicenter-randomized-controlled-trial
#17
Mei-Feng Li, Xiao-Li Li, Kai-Liang Fan, Ying-Yi Yu, Jing Gong, Shu-Ying Geng, Ya-Feng Liang, Ling Huang, Ji-Hua Qiu, Xing-Han Tian, Wen-Ting Wang, Xiao-Lu Zhang, Qing-Xia Yu, Yuan-Feng Zhang, Peng Lin, Li-Na Wang, Xin Li, Ming Hou, Lu-Yi Liu, Jun Peng
BACKGROUND: Studies in murine models suggested that platelet desialylation was an important mechanism of thrombocytopenia during sepsis. METHODS: First, we performed a prospective, multicenter, observational study that enrolled septic patients with or without thrombocytopenia to determine the association between platelet desialylation and thrombocytopenia in patients with sepsis, severe sepsis, and septic shock. Gender- and age-matched healthy adults were selected as normal controls in analysis of the platelet desialylation levels (study I)...
May 11, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28483722/combined-interventions-for-mitigation-of-an-influenza-a-h1n1-2009-outbreak-in-a-physical-training-camp-in-beijing-china
#18
Chen-Yi Chu, U Chandimal de Silva, Jin-Peng Guo, Yong Wang, Liang Wen, Vernon J Lee, Shen-Long Li, Liu-Yu Huang
OBJECTIVES: Many studies have suggested the effectiveness of single control measures in the containment and mitigation of pandemic influenza A (H1N1) 2009. The effects of combined interventions by multiple control measures in reducing the impact of an influenza A (H1N1) 2009 outbreak in a closed physical training camp in Beijing, China were evaluated. METHODS: Oseltamivir was prescribed for the treatment of confirmed cases and possible cases and as prophylaxis for all other participants in this training camp...
May 5, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28483551/antiviral-activity-of-formyl-peptide-receptor-2-antagonists-against-influenza-viruses
#19
Noémie Courtin, Aurélien Fotso Fotso, Pierre Fautrad, Floriane Mas, Marie-Christine Alessi, Béatrice Riteau
Influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. The aim of the study was to evaluate the effect of FPR2 antagonists PBP10 and BOC2 on influenza virus replication. We determined that these molecules exhibit antiviral effects against influenza A (H1N1, H3N2, H6N2) and B viruses. FPR2 antagonists used in combination with oseltamivir showed additive antiviral effects. Mechanistically, the antiviral effect of PBP10 and BOC2 is mediated through early inhibition of virus-induced ERK activation...
May 5, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28480248/oseltamivir-use-among-children-and-adults-hospitalized-with-community-acquired-pneumonia
#20
Ikwo K Oboho, Anna Bramley, Lyn Finelli, Alicia Fry, Krow Ampofo, Sandra R Arnold, Wesley H Self, Derek J Williams, D Mark Courtney, Yuwei Zhu, Evan J Anderson, Carlos G Grijalva, Jonathan A McCullers, Richard G Wunderink, Andrew T Pavia, Kathryn M Edwards, Seema Jain
BACKGROUND: Data on oseltamivir treatment among hospitalized community-acquired pneumonia (CAP) patients are limited. METHODS: Patients hospitalized with CAP at 6 hospitals during the 2010-2012 influenza seasons were included. We assessed factors associated with oseltamivir treatment using logistic regression. RESULTS: Oseltamivir treatment was provided to 89 of 1627 (5%) children (<18 years) and 143 of 1051 (14%) adults. Among those with positive clinician-ordered influenza tests, 39 of 61 (64%) children and 37 of 48 (77%) adults received oseltamivir...
2017: Open Forum Infectious Diseases
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