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https://www.readbyqxmd.com/read/28735300/caveolin-1-expression-as-a-prognostic-marker-in-triple-negative-breast-cancers-of-asian-women
#1
Joe Yeong, Aye Aye Thike, Murasaki Ikeda, Jeffrey Chun Tatt Lim, Bernett Lee, Seigo Nakamura, Jabed Iqbal, Puay Hoon Tan
BACKGROUND: Triple-negative breast cancers (TNBCs) are defined by their lack of oestrogen receptor, progesterone receptor and epidermal growth factor receptor 2. Although heterogeneous, the majority are aggressive and treatment options are limited. Caveolin acts as tumour suppressor or promoter depending on the cancer type. AIM: In this study, we aimed to determine if the expression levels of the candidate biomarker caveolin-1 on stromal or tumour cells were associated with clinicopathological parameters and disease outcomes in TNBCs from an ethnically diverse cohort of Asian women...
July 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28735273/relationship-between-trying-an-electronic-cigarette-and-subsequent-cigarette-experimentation-in-scottish-adolescents-a-cohort-study
#2
Catherine Best, Farhana Haseen, Dorothy Currie, Gozde Ozakinci, Anne Marie MacKintosh, Martine Stead, Douglas Eadie, Andy MacGregor, Jamie Pearce, Amanda Amos, John Frank, Sally Haw
BACKGROUND: This study examines whether young never smokers in Scotland, UK, who have tried an e-cigarette are more likely than those who have not, to try a cigarette during the following year. METHODS: Prospective cohort survey conducted in four high schools in Scotland, UK during February/March 2015 (n=3807) with follow-up 1 year later. All pupils (age 11-18) were surveyed. Response rates were high in both years (87% in 2015) and 2680/3807 (70.4%) of the original cohort completed the follow-up survey...
July 22, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28735257/prognostic-factors-of-overall-survival-and-cancer-specific-survival-in-patients-with-resected-early-stage-rectal-adenocarcinoma-a-seer-based-study
#3
Ko-Chao Lee, Kuan-Chih Chung, Hong-Hwa Chen, Chia-Cheng Liu, Chien-Chang Lu
The benefits of radiotherapy for colorectal cancer are well documented, but the impact of adjuvant radiotherapy on early-stage rectal adenocarcinoma remains unclear. This study aimed to identify predictors of overall survival (OS) and cancer-specific survival (CSS) in patients with stage II rectal adenocarcinoma treated with preoperative or postoperative radiation therapy. Patients with early-stage rectal adenocarcinoma in the postoperative state were identified using the Surveillance, Epidemiology, and End Results database...
July 21, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28735180/cell-phone-use-while-driving-does-peer-reported-use-predict-emerging-adult-use
#4
Neha Trivedi, Denise Haynie, Joe Bible, Danping Liu, Bruce Simons-Morton
Secondary task engagement such as cell phone use while driving is a common behavior among adolescents and emerging adults. Texting and other distracting cell phone use in this population contributes to the high rate of fatal car crashes. Peer engagement in similar risky driving behaviors, such as texting, could socially influence driver phone use behavior. The present study investigates the prospective association between peer and emerging adult texting while driving the first year after high school. Surveys were conducted with a national sample of emerging adults and their nominated peers...
July 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28734908/why-transition-risk-to-psychosis-is-not-declining-at-the-oasis-ultra-high-risk-service-the-hidden-role-of-stable-pretest-risk-enrichment
#5
P Fusar-Poli, E Palombini, C Davies, D Oliver, I Bonoldi, V Ramella-Cravaro, P McGuire
BACKGROUND: The reason for declining risk to psychosis across individuals assessed and meeting Ultra High Risk (UHR) criteria is still unclear. No studies have investigated the potential substantial role of the underlying risk enrichment across all the individuals undergoing an UHR assessment. METHODS: Cohort study including all non-psychotic subjects who were assessed on suspicion of psychosis risk by the OASIS UHR service in the period 2001 to 2015. Posttest (after UHR assessment) and pretest risk (before UHR assessment) of psychosis were stratified and compared across three time periods (2001-2005, 2006-2010, 2011-2015) with Cox analysis and modulating factors were investigated...
July 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28734894/glce-rs3865014-val597ile-polymorphism-is-associated-with-breast-cancer-susceptibility-and-triple-negative-breast-cancer-in-siberian-population
#6
Valentina A Belyavskaya, Tatiana Y Prudnikova, Natalya V Domanitskaya, Nikolay V Litviakov, Vladimir N Maksimov, Nadezhda V Cherdyntseva, Elvira V Grigorieva
d-Glucuronyl C5-epimerase (GLCE) is one of key enzymes in heparan sulfate biosynthesis and possesses tumour-suppressor function in breast carcinogenesis. Here, we investigated a potential involvement of GLCE polymorphism(s) in breast cancer development in Siberian women population. Comprehensive analysis of SNP databases revealed GLCE rs3865014 (Val597Ile) missense polymorphism as the main significantly present in human populations. According the TaqMan-based SNP assay, allele distributions for the rs3865014 (A>G) were similar in healthy Siberian women (n=136) and cancer patients (n=129) (A0,73:G0,27) and intermediate between the European and Asian populations, while genotype distributions were different, with the increase of AG rate in breast cancer patients (OR=1...
July 19, 2017: Gene
https://www.readbyqxmd.com/read/28734861/low-food-allergy-prevalence-despite-delayed-introduction-of-allergenic-foods-data-from-the-gusto-cohort
#7
Elizabeth Huiwen Tham, Bee Wah Lee, Yiong Huak Chan, Evelyn Xiu Ling Loo, Jia Ying Toh, Anne Goh, Oon Hoe Teoh, Fabian Yap, Kok Hian Tan, Keith M Godfrey, Mary Foong Fong Chong, Hugo P S Van Bever, Yap Seng Chong, Lynette Pei-Chi Shek
BACKGROUND: There is mounting evidence that early introduction of allergenic food decreases the risk of food allergy development, especially in high-risk infants with eczema. However, there is a lack of data to suggest whether this association holds true in Asian populations. OBJECTIVE: To investigate the relationship between the timing of introduction of allergenic foods and food allergy outcomes in infants in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28734663/mtdna-sequence-diversity-of-hazara-ethnic-group-from-pakistan
#8
Allah Rakha, Fatima, Min-Sheng Peng, Atif Adan, Rui Bi, Memona Yasmin, Yong-Gang Yao
The present study was undertaken to investigate mitochondrial DNA (mtDNA) control region sequences of Hazaras from Pakistan, so as to generate mtDNA reference database for forensic casework in Pakistan and to analyze phylogenetic relationship of this particular ethnic group with geographically proximal populations. Complete mtDNA control region (nt 16024-576) sequences were generated through Sanger Sequencing for 319 Hazara individuals from Quetta, Baluchistan. The population sample set showed a total of 189 distinct haplotypes, belonging mainly to West Eurasian (51...
July 10, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28734496/endometrial-cancer-surveillance-adherence-reduces-utilization-and-subsequent-costs
#9
Zachary P Schwartz, Melissa K Frey, Sarah Philips, John P Curtin
OBJECTIVES: In June 2011, the SGO recommended that physical exam and symptoms be the primary surveillance methods in patients with endometrial cancer. We sought to evaluate adherence to these guidelines by comparing the use of CT scans, paps and serum CA125 ordered for endometrial cancer surveillance before and after publication of these guidelines. METHODS: A retrospective review was performed for all patients undergoing surveillance for endometrial cancer at a single institution between June 2009 and June 2013...
July 19, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28734239/stigma-resistance-and-its-association-with-internalised-stigma-and-psychosocial-outcomes-among-psychiatric-outpatients
#10
Ying Wen Lau, Louisa Picco, Shirlene Pang, Anitha Jeyagurunathan, Pratika Satghare, Siow Ann Chong, Mythily Subramaniam
Studies have suggested that stigma resistance plays an important role in the recovery from mental illness. However, there has been limited research in Asian countries that has examined the benefits of stigma resistance among the mentally ill in Asian populations. Hence, this study aimed to assess the prevalence of stigma resistance and establish the socio-demographic correlates of stigma resistance, as well as its association with internalised stigma and psychosocial outcomes among a multi-ethnic population of 280 outpatients with obsessive compulsive disorder (OCD), schizophrenia, depressive disorders and anxiety disorders in Singapore...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734231/weight-misperception-and-disordered-weight-control-behaviors-among-u-s-high-school-students-with-overweight-and-obesity-associations-and-trends-1999-2013
#11
Vivienne M Hazzard, Samantha L Hahn, Kendrin R Sonneville
OBJECTIVE: To examine prevalence of weight misperception (incongruence between one's perceived weight status and one's actual weight status) and disordered weight control behaviors (DWCBs; unhealthy behaviors aiming to control or modify weight), associations between weight misperception and DWCBs, and temporal trends in prevalence and associations among adolescents with overweight and obesity from 1999 to 2013. METHODS: Self-reported data from eight biennial cycles (1999-2013) of the cross-sectional national Youth Risk Behavior Survey were used in analyses restricted to respondents with overweight/obesity...
July 13, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28734192/trajectories-of-risk-behaviors-across-adolescence-and-young-adulthood-the-role-of-race-and-ethnicity
#12
Eunhee Park, Thomas P McCoy, Jennifer Toller Erausquin, Robin Bartlett
INTRODUCTION: Despite important advances of longitudinal research in substance use behaviors, most studies stratify analyses by gender or race, which limits the ability to directly compare the likelihood of a particular developmental pathway across demographic groups. Thus, there is critical need for well-designed research to examine the associations of race/ethnicity with developmental trajectories of substance use behaviors across adolescence through adulthood. METHODS: Using an accelerated longitudinal design, we examined behaviors across ages 12-31 from Waves I-IV of the National Longitudinal Study of Adolescent to Adult Health...
July 15, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734020/molecular-analysis-of-brazilian-patients-with-combined-pituitary-hormone-deficiency-and-orthotopic-posterior-pituitary-lobe-reveals-eight-different-prop1-alterations-with-three-novel-mutations
#13
Joao L O Madeira, Mirian Y Nishi, Marilena Nakaguma, Anna F Benedetti, Isabela Peixoto Biscotto, Thamiris Fernandes, Thiago Pequeno, Thalita Figueiredo, Marcela M Franca, Fernanda A Correa, Aline P Otto, Milena Abrão, Mirta B Miras, Silvana Santos, Alexander A L Jorge, Everlayny F Costalonga, Berenice B Mendonca, Ivo J P Arnhold, Luciani R Carvalho
BACKGROUND: Mutations in PROP1, HESX1, and LHX3 are associated with combined pituitary hormone deficiency (CPHD) and orthotopic posterior pituitary lobe (OPP). OBJECTIVE: To identify mutations in PROP1, HESX1, and LHX3 in a large cohort of patients with CPHD and OPP (35 Brazilian, 2 Argentinian). DESIGN AND METHODS: We studied 23 index patients with CPHD and OPP (6 familial and 17 sporadic) as well as 14 relatives. PROP1 was sequenced by the Sanger method in all except one sporadic case studied using a candidate gene panel...
July 22, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28733957/a-review-of-biomarkers-for-alzheimer-s-disease-in-down-syndrome
#14
REVIEW
Ni-Chung Lee, Yin-Hsiu Chien, Wuh-Liang Hwu
Down syndrome (Trisomy 21; DS) is a unique disease known to be associated with early-onset Alzheimer's disease (AD). The initial presentation of AD in DS is usually difficult to recognize, owing to the underlying intellectual disabilities. Using biomarkers as a prediction tool for detecting AD in at-risk people with DS may benefit patient care. The objective of this review is to discuss the utility of biomarkers in DS on the basis of the pathophysiology of the disease and to provide an update on recent studies in this field...
July 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28733936/an-examination-of-the-association-of-multiple-acculturation-measures-with-asthma-status-among-elementary-school-students-in-el-paso-texas
#15
Mónica Siañez, Linda Highfield, Héctor Balcazar, Timothy Collins, Sara Grineski
Some researchers posit that the lower prevalence of asthma among those of Mexican descent may result from an under-diagnosis and recommend a critical appraisal of factors related to race/ethnicity, like acculturation, and its influence on asthma status. Survey data were analyzed using multinomial logistic regression to examine the association of child's asthma status (no wheezing/no asthma symptoms, possible undiagnosed and diagnosed asthma) with measures of acculturation among Hispanic students (n = 1095)...
July 21, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28733797/population-genetic-analysis-of-a-21-plex-dip-panel-in-seven-chinese-ethnic-populations
#16
Youjing Jiang, Wang He, Hui Wang, Dan Chen, Xiaogang Bai, Jienan Li, Weibo Liang, Lin Zhang
A 21-plex DIP (deletion and insertion polymorphism) panel has a good performance in analyzing biogeographic ancestry in three main global population groups (European, African, and Asian). This panel was used to investigate 450 unrelated individuals in seven Chinese ethnic groups (Han, Dong, Miao, Zhuang, Uyghur, Tibetan, and Mongolian). Allele frequencies were calculated. Mho (mean value of observed heterozygosity) ranged from 0.3019 to 0.4367, MHe (mean value of expected heterozygosity) ranged from 0.31175 to 0...
July 21, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28733772/state-minority-health-officers-perceptions-of-their-successes-and-barriers-to-reducing-racial-and-ethnic-health-disparities
#17
Aaron J Diehr, Timothy R Jordan, James H Price, Jiunn-Jye Sheu, Joseph A Dake
BACKGROUND: Minimal research has been conducted to examine the impact and reach of state offices of minority health (SOMH) and their role in reducing racial and ethnic health disparities within their states. Accordingly, the purpose of this study was to describe the shared experiences of SOMH officers to provide context for why these individuals believe that state organizational efforts have not yielded much success in reducing racial and ethnic health disparity gaps. METHODS: Using a telephone interview guide, the investigators conducted telephone interviews with SOMH officers...
July 21, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28733223/sequencing-of-fic1-bsep-and-mdr3-in-a-large-cohort-of-patients-with-cholestasis-revealed-a-high-number-of-different-genetic-variants
#18
Carola Dröge, Michele Bonus, Ulrich Baumann, Caroline Klindt, Elke Lainka, Simone Kathemann, Florian Brinkert, Enke Grabhorn, Eva-Doreen Pfister, Daniel Wenning, Alexander Fichtner, Daniel N Gotthardt, Karl Heinz Weiss, Patrick McKiernan, Ratna Dua Puri, I C Verma, Stefanie Kluge, Holger Gohlke, Lutz Schmitt, Ralf Kubitz, Dieter Häussinger, Verena Keitel
BACKGROUND&AIMS: The bile salt export pump (BSEP, ABCB11), multidrug resistance protein 3 (MDR3, ABCB4) and the ATPase familial intrahepatic cholestasis 1 (FIC1, ATP8B1) mediate bile formation. Mutations in these genes underlie cholestatic liver diseases ranging from intrahepatic cholestasis of pregnancy, benign recurrent intrahepatic cholestasis or low phospholipid-associated cholelithiasis to progressive familial intrahepatic cholestasis. METHODS: Coding exons with flanking intron regions of ATP8B1, ABCB11, and ABCB4 were sequenced in cholestatic patients with assumed genetic cause...
July 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28732350/the-prevalence-of-polycystic-ovary-syndrome-in-reproductiveaged-women-of-different-ethnicity-a-systematic-review-and-meta-analysis
#19
Tao Ding, Paul J Hardiman, Irene Petersen, Fang-Fang Wang, Fan Qu, Gianluca Baio
The prevalence of PCOS was investigated in many studies in different continents. However, there is no established prevalence of PCOS for distinct ethnic groups. In the current analysis, we conducted searches in PubMed, The Cochrane Library, EMBASE, CINAHL up to Jan. 2017 to identify studies reporting prevalence of PCOS in the general female population. Forty-two studies were identified, with 13 eligible for evidence synthesis. The prevalence among different ethnicity was estimated using random effect modelling...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732138/involving-citizens-in-priority-setting-for-public-health-research-implementation-in-infection-research
#20
Timothy M Rawson, Enrique Castro-Sánchez, Esmita Charani, Fran Husson, Luke S P Moore, Alison H Holmes, Raheelah Ahmad
BACKGROUND: Public sources fund the majority of UK infection research, but citizens currently have no formal role in resource allocation. To explore the feasibility and willingness of citizens to engage in strategic decision making, we developed and tested a practical tool to capture public priorities for research. METHOD: A scenario including six infection themes for funding was developed to assess citizen priorities for research funding. This was tested over two days at a university public festival...
July 21, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
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