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https://www.readbyqxmd.com/read/28436051/a-novel-mass-spectrometry-based-method-for-simultaneous-determination-of-asymmetric-and-symmetric-dimethylarginine-l-arginine-and-l-citrulline-optimized-for-lc-ms-tof-and-lc-ms-ms
#1
Jerzy Wiśniewski, Mariusz G Fleszar, Joanna Piechowicz, Małgorzata Krzystek-Korpacka, Angelika Chachaj, Andrzej Szuba, Katarzyna Lorenc-Kukula, Leszek Masłowski, Wojciech Witkiewicz, Andrzej Gamian
Nitric oxide (NO) is a regulatory molecule involved in many biological processes. NO is produced by nitric oxide synthase by conversion of L-arginine to L-citrulline. L-arginine methylated derivatives, asymmetric and symmetric dimethylarginines (ADMA and SDMA), regulate L-arginine availability and the activity of nitric oxide synthase. As such, they have been frequently investigated as potential biomarkers in pathologies associated with dysfunctions in NO synthesis. Here, we present a new multistep analytical methodology based on liquid chromatography combined with mass spectrometry for the accurate identification of L-arginine, L-citrulline, ADMA, and SDMA...
April 24, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28411704/lymphoscintigraphic-abnormalities-in-the-contralateral-lower-limbs-of-patients-with-unilateral-lymphedema
#2
Camila Alcoforado de Almeida, Esdras Marques Lins, Simone Cristina Soares Brandão, Álvaro Antônio Bandeira Ferraz, Flavia Cristina Morone Pinto, Silvio Romero de Barros Marques
OBJECTIVE: The contralateral limbs of patients with unilateral lymphedema in the lower limbs (LLs) can exhibit abnormal lymphatic circulation, even in the absence of lymphedema. This idea is based on a number of reports that have studied isolated cases using lymphoscintigraphy. It is likely that these patients previously had some form of lymphopathy, and the lymphedema arose after the action of some external factor. However, there are no studies in the literature that adequately assess the asymptomatic contralateral limbs of these patients or address the prevalence and characteristics of the abnormal lymphatic circulation in these limbs...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28240041/credentialing-in-interventional-therapy-in-europe-comparison-of-curricula-including-endovascular-therapy-of-arterial-diseases
#3
Karl-Ludwig Schulte, Pia M Jungmann, Vladimir Makaloski, Lino Goncalves, Markus Steinbauer, Susanne Vonberg, Beatrix B Doerr, Ralf Langhoff, Frederic Baumann
 The prevalence of peripheral artery disease (PAD) is continuously increasing. In addition, the treatment of PAD has changed substantially over the last decades. Novel treatment modalities and diagnostic tools were developed and endovascular therapy was established as a first-line therapy. In consequence, vascular medicine has become an interdisciplinary field, involving different specialties such as internal medicine/cardiology, internal medicine/angiology, vascular surgery, and (interventional) radiology...
February 27, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28139902/the-undergraduate-teaching-of-vascular-surgery-in-greek-medical-schools-theory-and-clinical-practice
#4
Vasileios Bafitis, Christodoulos Keskinis, Foteini Katsikogianni, Ioannis Katsaros, Miltos K Lazarides, Efstratios Georgakarakos
BACKGROUND: The objective of this survey was to document and analyze the teaching methods of vascular surgery (VS) in the undergraduate curricula of the seven Greek medical schools. METHODS: The type of VS subject (core, selective, integrated in other subject), the type of clinical practice, and the specialty of the VS tutors were recorded from the curriculum of each medical school, as documented online. The information was cross-checked with the academic tutors of each Medical School via phone contact and verified by ten medical students of Medical School...
January 31, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28132132/impaired-vascular-function-in-sarcoidosis-patients
#5
I Tuleta, D Skowasch, L Biener, C Pizarro, R Schueler, G Nickenig, N Schahab, C Schaefer, S Pingel
A common feature of sarcoidosis and atherosclerosis is a chronic systemic inflammatory reaction. Our hypothesis was that sarcoidosis may negatively influence the vessel status. We addressed the issue by examining preatherosclerotic vascular alternations using an ultrasound-based speckle-tracking method in 72 sarcoidosis patients and 15 matched controls. To find potential factors which may have a deleterious influence on arterial performance, different subgroups of sarcoidosis, such as sarcoidosis with or without cortisone therapy, pulmonary sarcoidosis in early and advanced stages, pulmonary sarcoidosis alone or combined with extrapulmonary sarcoidosis, and sarcoidosis with or without elevated blood levels of angiotensin converting enzyme (ACE)/soluble interleukin 2 receptor (sIL-2R) were investigated...
January 29, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28053972/lower-extremity-and-carotid-artery-disease-in-copd
#6
Carmen Pizarro, Fabian Linnhoff, Fabian van Essen, Simon Pingel, Christian Alexander Schaefer, Nadjib Schahab, Rolf Fimmers, Georg Nickenig, Dirk Skowasch
In view of their common chronic inflammatory process, we sought to determine the linkage between peripheral artery disease and chronic obstructive pulmonary disease (COPD). 107 COPD patients (mean±sd age 64.6±10.4 years, 52.2% male) and 22 control smokers without previously diagnosed peripheral artery disease underwent standardised angiological examination for lower extremity artery disease (LEAD) and carotid artery disease. LEAD was significantly more prevalent in COPD patients than in controls (80.4% versus 54...
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/28043217/modulation-of-carotid-strain-by-statin-therapy-in-atherosclerosis-patients
#7
Christian Alexander Schaefer, Anna Katharina Blatzheim, Sebastian Gorgonius Passon, Kristin Solveig Pausewang, Nadjib Schahab, Georg Nickenig, Dirk Skowasch, Robert Schueler, Christoph Hammerstingl, Simon Pingel
BACKGROUND: The beneficial effect of statin therapy on the progress of atherosclerotic disease has been demonstrated by numerous studies. Vascular strain imaging is an arising method to evaluate arterial stiffness. Our study examined whether an influence of statin therapy on the vessel wall could be detected by vascular strain imaging. PATIENTS AND METHODS: 88 patients with recently detected atherosclerosis underwent an angiological examination including ankle-brachial index (ABI), pulse wave index (PWI), central puls ewave velocity and duplex ultrasound...
January 3, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27992028/measurement-of-the-area-of-venous-ulcers-using-two-software-programs
#8
Thaís Dresch Eberhardt, Suzinara Beatriz Soares de Lima, Luis Felipe Dias Lopes, Eline de Lima Borges, Teresinha Heck Weiller, Graziele Gorete Portella da Fonseca
Objective: to compare the measurement area of venous ulcers using AutoCAD(r) and Image Tool software. Method: this was an assessment of reproducibility tests conducted in a angiology clinic of a university hospital. Data were collected from 21 patients with venous ulcers, in the period from March to July of 2015, using a collection form and photograph of wounds. Five nurses (evaluators) of the hospital skin wound study group participated. The wounds were measured using both software programs...
December 19, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27935875/-modified-circulating-low-density-lipoproteins-pathogenetic-significance-in-angiology
#9
REVIEW
Ya D Babintseva, V P Karagodin, A N Orekhov
Low-density lipoproteins (LDLs) having various modifications are known to be atherogenic, i. e., possessing ability of inducing atherosclerosis. Circulating modified LDLs (cmLDLs) were found in blood of patients diagnosed with atherosclerosis confirmed angiographically. They appear to contain 2-3-fold less sialic acid as compared to LDLs in blood of apparently healthy people; cmLDLs differ by their physical properties: having higher density, smaller diameter, and greater electronegativity; by chemical properties: the amount of neutral sugars (N-acetyl-galactosamine, N-acetyl-glucosamine, galactose and glucose) in cmLSLs of patients with atherosclerosis is 1,5-2 times lower than in native lipoproteins, the levels of free and etherified cholesterol and triglycerides, monoglycerides and free fatty acids are higher, cmLDLs are oxidized and contain altered apolipoprotein B...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27927085/increased-vascular-occlusion-in-patients-with-pseudoxanthoma-elasticum
#10
Simon Pingel, Kristin Solveig Pausewang, Sebastian Gorgonius Passon, Anna Katharina Blatzheim, Martin Gliem, Peter Charbel Issa, Doris Hendig, Fritz Horlbeck, Izabela Tuleta, Georg Nickenig, Nadjib Schahab, Dirk Skowasch, Christian Alexander Schaefer
BACKGROUND: Pseudoxanthoma elasticum (PXE) is an autosomal recessive inherited multisystem disorder of the connective tissue caused by a loss-of-function mutation of the ABCC6 gene. It can affect the cardiovascular system, presumably leading to a high prevalence of atherosclerosis. PATIENTS AND METHODS: 46 PXE patients and 18 controls underwent an angiological examination consisting of measurement of ankle-brachial index (ABI), strain-gauge arterial reserve (SGAR), arterial resting perfusion, pulse wave index (PWI), central pulse wave velocity, and ultrasound examination...
December 8, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27844109/endovascular-therapy-research-in-lower-limb-peripheral-arterial-disease-published-over-a-5-year-period-who-is-publishing-and-where
#11
H Asadi, R J Lee, M Sheehan, P Thanaratam, D M Lee, A M Lee, M J Lee
INTRODUCTION: Peripheral arterial disease (PAD) is being increasingly managed by endovascular therapies. In this study, we identified the clinical services publishing research as well as the journals of publication over a 5-year period. METHODS: Twenty keywords and phrases related to endovascular intervention were identified, and a literature search was performed through the PubMed database from January 2009 to January 2014. Inclusion criteria were English language, study population more than five patients, and matching the keyword search...
March 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27695304/invasive-coronary-angiography-in-patients-with-acute-exacerbated-copd-and-elevated-plasma-troponin
#12
Carmen Pizarro, Neele Herweg-Steffens, Martin Buchenroth, Wolfgang Schulte, Christian Schaefer, Christoph Hammerstingl, Nikos Werner, Georg Nickenig, Dirk Skowasch
BACKGROUND: In acute exacerbation of COPD, increased plasma levels of cardiac troponin are frequent and associated with increased mortality. Thus, we aimed at prospectively determining the diagnostic value of coronary angiography in patients with exacerbated COPD and concomitantly elevated cardiac troponin. PATIENTS AND METHODS: A total of 88 patients (mean age 72.9±9.2 years, 56.8% male) hospitalized for acute exacerbation of COPD with elevated plasma troponin were included...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27626244/-pathophysiological-and-clinical-aspects-of-using-l-arginine-in-cardiology-and-angiology
#13
REVIEW
V V Valeev, A P Trashkov, A L Kovalenko, A G Vasil'ev
Presented herein is a review of scientific publications dedicated to studying the pharmacodynamics of L-arginine and possibilities of its clinical application. Interest to L-arginine is associated, first of all, with its role as a precursor in endogenous synthesis of nitric oxide (NO), playing an important role in regulation of the functional state of the vascular wall. According to numerous studies, oral and parenteral administration of L-arginine restores endothelial production of NO in such diseases as atherosclerosis, hypertension, type 2 diabetes mellitus, obliterating diseases of arteries of lower extremities...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27607889/-management-of-the-therapy-of-pulmonary-sequestration-a-retrospective-multicentre-study
#14
E Schlöricke, M Hoffmann, P Kujath, J Facklam, M Henning, C Wissgott, F Scheer, M Zimmermann, E Palade
BACKGROUND: Pulmonary sequestration is a rare pulmonary malformation whose complex pathogenesis is not completely understood. Extrapulmonary sequestrations are always hereditary malformations and are usually diagnosed during childhood. Some intralobar sequestrations in adults, by contrast, seem to be acquired. The clinical presentation is non-specific and often misinterpreted, which results in delayed diagnosis. Surgical resection continues to be the gold standard. Despite the low incidence, new technologies developed in the past few decades, e...
September 2016: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/27526424/-cardio-vascular-risk-factors-control-in-elderly-patients-with-peripheral-artery-disease
#15
Dorota Studzińska, Barbara Gryglewska, Maria Wojnarowska, Joanna Paleń, Bogusław Rudel, Tomasz Grodzicki
OBJECTIVE: The assessment of control of modifiable risk factors among elderly patients with peripheral artery disease (PAD) admitted to the hospital angiology ward. METHODS: The results of treatment of dyslipidemia (DL), hypertension (HT), diabetes mellitus (DM) and prevalence of cigarette smoking were assessed among older (>65 years old, group I) and younger patients (group II) with PAD in a admission day to hospital. RESULTS: The study population included 154 patients (I--92 and II--65 subjects) aged 67...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27481194/-angiology-is-moving-forward
#16
Debora Karetová
Vascular medicine treats many diseases - ischemic syndromes of different arterial bed (with the specifics of their territorial function), venous and lymphatic diseases. A number of states in angiology are urgent, potentially life-threating. Examples include aneurysm rupture, acute limb ischemia, or deep vein thrombosis and pulmonary embolism.On the other hand, chronic vascular disease (eg., peripheral arterial disease or chronic disease of superficial veins) require a differentiated approach according to the manifestation and the emphasis is given on prevention and treatment of disposing conditions...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27412797/new-semiquantitative-ultrasonographic-score-for-peripheral-arterial-disease-assessment-and-its-association-with-cardiovascular-risk-factors
#17
Luca Santoro, Pietro Manuel Ferraro, Andrea Flex, Antonio Nesci, Giuseppe De Matteis, Angela Di Giorgio, Vincenzo Zaccone, Giovanni Gambaro, Antonio Gasbarrini, Angelo Santoliquido
The data concerning the distribution, extent and progression of peripheral arterial disease (PAD), as well as its association with traditional cardiovascular (CV) risk factors, have generally been obtained from studies of patients in advanced stages of the disease undergoing surgical or endovascular treatment. In this study, we have introduced a new semiquantitative ultrasonographic score (ultrasonographic lower limb atherosclerosis (ULLA) score) that is able to categorize lower limb atherosclerotic lesions at all stages of PAD...
December 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27088792/-history-of-the-4th-department-of-internal-medicine-of-the-first-faculty-of-medicine-at-charles-university-and-the-general-university-hospital-in-prague
#18
Petr Bartůněk
In 2015, the doctors and nurses of the 4th Department of Internal Medicine of the First Faculty of Medicine, Charles University and the General University Hospital in Prague celebrated the 70th anniversary of its founding. The article summarizes the clinics contribution to the field of internal medicine, and particularly to angiology, hepatogastroenterology and lipidology. It comments the clinics current activities and the possibilities of its further development. Attention is also paid to the tradition of high ethical and professional standards of medical care in accordance with the norms established by the clinic's founder, prof...
2016: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/27052040/patterns-in-the-management-of-superficial-vein-thrombosis
#19
Christos Karathanos, Konstantinos Spanos, Vasileios Lachanas, Athanasios Athanasoulas, Athanasios D Giannoukas
OBJECTIVE: To highlight current practice patterns in management of superficial vein thrombosis. METHODS: An electronic survey was conducted using the mailing lists of the Mediterranean League of Angiology and Vascular Surgery and European Venous Forum regarding superficial vein thrombosis diagnosis, investigation, and treatment. RESULTS: The response rate was 41% (175/430) and the majority of the participants were vascular surgeons practicing in a hospital...
April 6, 2016: Phlebology
https://www.readbyqxmd.com/read/26946695/-news-in-angiology-and-hemostasis
#20
Françoise Boehlen, Marc Blondon, Pierre Fontana
This update describes contemporary studies of clinical relevance in angiology and hemostasis. We discuss newer developments for the treatment of haemophilia, with a focus on drugs with longer-half lives. Direct anticoagulants (DOAC: rivaroxaban, apixaban, edoxaban and dabigatran) and their approved prescription in Switzerland are summarized, with a description of antidotes that will be available in the near future. We will present new data on the utility of cancer screening at the diagnosis of idiopathic venous thromboembolism (VTE) and on the evaluation of DOAC in patients with cancer-related VTE...
January 13, 2016: Revue Médicale Suisse
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