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https://www.readbyqxmd.com/read/29331960/pregnancy-loss-and-carotid-intima-media-thickness-in-mexican-women
#1
Sandra A Hartasanchez, Mario Flores-Torres, Adriana Monge, Elsa Yunes, Beatriz Rodriguez, Carlos Cantu-Brito, Daniela Colaci, Hector Lamadrid-Figueroa, Ruy Lopez-Ridaura, Martin Lajous
BACKGROUND: Cardiovascular disease in women often develops without conventional risk factors. Prenatal loss is a common pregnancy outcome that may result in physiological changes can increase the potential future risk of cardiovascular disease. Insufficient information exists regarding the impact of pregnancy loss on early markers of cardiovascular disease risk. METHODS AND RESULTS: Cross-sectional analysis of 1767 disease-free women from the MTC (Mexican Teachers' Cohort) who had been pregnant was used to evaluate the relationship between pregnancy loss and carotid intima-media thickness (IMT)...
January 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29331534/perinatal-palliative-care-integration-in-a-united-states-nurse-midwifery-education-program
#2
Jenna A LoGiudice, Eileen O'Shea
Midwifery students with perinatal palliative care education develop a skillset to provide holistic midwifery care to women and families who are experiencing stillbirth or life-limiting fetal diagnoses. This paper presents a model of perinatal palliative care in a United States midwifery education program. By utilizing evidence based practices and national programs, perinatal palliative care can be threaded through midwifery curricula to achieve international standards of practice and competencies. Most importantly, enhancing perinatal palliative care education will better prepare future midwives for when a birth outcome is not what was expected at the outset of a pregnancy...
December 28, 2017: Midwifery
https://www.readbyqxmd.com/read/29329078/schmallenberg-virus-non-structural-protein-nsm-intracellular-distribution-and-role-of-non-hydrophobic-domains
#3
Franziska Kraatz, Kerstin Wernike, Sven Reiche, Andrea Aebischer, Ilona Reimann, Martin Beer
Schmallenberg virus (SBV) induces fetal malformation, abortions and stillbirth in ruminants. While the non-structural protein NSs is a major virulence factor, the biological function of NSm, the second non-structural protein which consists of three hydrophobic transmembrane (I, III, V) and two non-hydrophobic regions (II, IV), is still unknown. Here, a series of NSm mutants displaying deletions of nearly the entire NSm or of the non-hydrophobic domains was generated and the intracellular distribution of NSm was assessed...
January 9, 2018: Virology
https://www.readbyqxmd.com/read/29326197/parents-2-study-protocol-pilot-of-parents-active-role-and-engagement-in-the-review-of-their-stillbirth-perinatal-death
#4
Danya Bakhbakhi, Dimitrios Siassakos, Claire Storey, Alexander Heazell, Mary Lynch, Laura Timlin, Christy Burden
BACKGROUND: The perinatal mortality review meeting that takes place within the hospital following a stillbirth or neonatal death enables clinicians to learn vital lessons to improve care for women and their families for the future. Recent evidence suggests that parents are unaware that a formal review following the death of their baby takes place. Many would welcome the opportunity to feedback into the meeting itself. Parental involvement in the perinatal mortality review meeting has the potential to improve patient satisfaction, drive improvements in patient safety and promote an open culture within healthcare...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29325773/how-safe-is-metformin-when-initiated-in-early-pregnancy-a-retrospective-5-year-study-of-pregnant-women-with-gestational-diabetes-mellitus-from-india
#5
Vanlalhruaii, Riddhi Dasgupta, Roshna Ramachandran, Jiji E Mathews, Annie Regi, Niranjan Thomas, Vijay Gupta, P Visalakshi, H S Asha, Thomas Paul, Nihal Thomas
BACKGROUND: The initiation of metformin in early pregnancy in Gestational Diabetes mellitus(GDM) remains controversial. The aim of our study was to assess the influence of Metformin on maternal and fetal outcomes when initiated within the first trimester of pregnancy in GDM. METHODS AND MATERIALS: A retrospective analysis of 540 women with diabetes complicating pregnancy (IADPSG criteria) over five years(January 2011 to May 2016)was done. The study population comprised of patients initiated on a)metformin within the first trimester (Group A:n=186),b) metformin after the first trimester(Group B:n=203) and c)insulin at any time during their pregnancy(Group C:n=151)...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29325266/-analysis-of-649-cases-of-stillbirth-in-third-trimester
#6
M N Hu, Y Zhang, W Zhao
Objective: To analyze the risk factors of stillbirth in third trimester. Methods: Clinical data of 649 cases of stillbirth in third trimester were analyzed retrospectively in 22 hospitals of Haidian district from October 2011 to September 2016, including the incidence, the maternal profile, the perinatal care during pregnancy and the causes of stillbirth. Results: (1) The incidence of stillbirth in third trimester in Haidian district from October 2011 to September 2016 was 0.293%(649/221 845). While the incidence in floating pregnant women (0...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29325264/-high-risk-factors-analysis-of-stillbirth
#7
Y Xiong, H X Xia, Y S Wang, X L Lin, T T Zhu, Y Zhao, X T Li
Objective: To explore the high risk factors of stillbirth. Methods: 176 cases of stillbirth were collected in the Obstetrics and Gynecology Hospital of Fudan University from January 1(st), 2010 to December 31(st), 2016. All cases were analyzed retrospectively, including general profile, high risk factors of stillbirth in different years and pregnancy periods. Results: (1) The incidence of stillbirth was 0.178%(176/98 785). Stillbirth occured mostly at 28-28(+6) gestational weeks (10.8%,19/176), and the second peak was 29-29(+6) weeks(10...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29325263/-analysis-of-2-204-stillbirths-in-11-hospitals-of-guangdong-province
#8
L Yu, M Tang, X H Fan, H M Du, H Tang, P Chen, S L Xing, C H Su, D J Chen
Objective: To analyze the incidence and causes of stillbirth in 11 hospitals of Guangdong province, and to explore the appropriate interventions. Methods: Clinical data of stillbirth in 11 hospitals of Guangdong province were collected from January 2014 to December 2016. The gestational weeks, causes, maternal conditions and other factors were analyzed. Results: (1) From 2014 to 2016, 103 472 newborns were delivered in the 11 hospitals, and the number of stillbirth was 2 204, with the incidence of 2.13%. Among them, 0...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29325262/-strengthen-the-management-of-pregnancy-decrease-the-stillbirth-incidence-of-china
#9
(no author information available yet)
No abstract text is available yet for this article.
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29324621/immediate-delivery-compared-with-expectant-management-in-late-preterm-prelabor-rupture-of-membranes-an-individual-participant-data-meta-analysis
#10
Johanna Quist-Nelson, Annemijn A de Ruigh, Anna Lene Seidler, David P van der Ham, Christine Willekes, Vincenzo Berghella, Eva Pajkrt, Jillian Patterson, David Espinoza, Jonathan Morris, Ben Mol, Lisa Askie
OBJECTIVE: To compare the effects of immediate delivery an expectant management among women whose pregnancies were complicated by preterm prelabor rupture of membranes (PROM) in the late preterm period (from 34 0/7 weeks until 36 6/7 weeks of gestation). DATA SOURCES: PubMed, Scopus, ClinicalTrials.gov, EMBASE, and the Cochrane Central Register of Controlled Trials were searched from inception until December 2016. METHODS OF STUDY SELECTION: We included all randomized controlled trials with individual participant data reporting on late preterm PROM with randomization to immediate delivery or expectant management...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29324606/obstetric-outcomes-after-failed-hysteroscopic-and-laparoscopic-sterilization-procedures
#11
Kristyn Brandi, Jake R Morgan, Michael K Paasche-Orlow, Rebecca B Perkins, OʼConnell Katharine White
OBJECTIVE: To compare obstetric outcomes after failed hysteroscopic and laparoscopic sterilization. METHODS: This retrospective cohort study examined pregnancy outcomes including live birth, preterm birth, stillbirth, spontaneous abortion, therapeutic abortion, ectopic pregnancies, and gestational trophoblastic disease using a commercial claims administrative database for the years 2007-2013. We used a Z-test to compare pregnancy outcomes per 100 person-years based on type of sterilization...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29324601/potentially-preventable-stillbirth-in-a-diverse-u-s-cohort
#12
Jessica M Page, Vanessa Thorsten, Uma M Reddy, Donald J Dudley, Carol J Rowland Hogue, George R Saade, Halit Pinar, Corette B Parker, Deborah Conway, Barbara J Stoll, Donald Coustan, Radek Bukowski, Michael W Varner, Robert L Goldenberg, Karen Gibbins, Robert M Silver
OBJECTIVE: To estimate the proportion of potentially preventable stillbirths in the United States. METHODS: We conducted a secondary analysis of 512 stillbirths with complete evaluation enrolled in the Stillbirth Collaborative Research Network from 2006 to 2008. The Stillbirth Collaborative Research Network was a multisite, geographically, racially, and ethnically diverse, population-based case-control study of stillbirth in the United States. Cases of stillbirth underwent standard evaluation that included maternal interview, medical record abstraction, biospecimen collection, postmortem examination, placental pathology, and clinically recommended evaluation...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29322220/diabetes-and-pregnancy-national-trends-over-a-15%C3%A2-year-period
#13
Sharon T Mackin, Scott M Nelson, Joannes J Kerssens, Rachael Wood, Sarah Wild, Helen M Colhoun, Graham P Leese, Sam Philip, Robert S Lindsay
AIMS/HYPOTHESIS: We aimed to examine time trends in national perinatal outcomes in pregnancies complicated by pre-existing type 1 or type 2 diabetes. METHODS: We analysed episode-level data on all obstetric inpatient delivery events (live or stillbirth) between 1 April 1998 and 31 March 2013 (n = 813,921) using the Scottish Morbidity Record (SMR02). Pregnancies to mothers with type 1 (n = 3229) and type 2 (n = 1452) diabetes were identified from the national diabetes database (Scottish Care Information-Diabetes), and perinatal outcomes were compared among women with type 1 diabetes, type 2 diabetes and those without diabetes...
January 11, 2018: Diabetologia
https://www.readbyqxmd.com/read/29321000/care-quality-following-intrauterine-death-in-spanish-hospitals-results-from-an-online-survey
#14
Paul Richard Cassidy
BACKGROUND: The objective of the study was to evaluate practices in Spanish hospitals after intrauterine death in terms of medical/ technical care and bereavement support care. METHODS: A cross-sectional descriptive study using an online self-completion questionnaire. The population was defined as women who had experienced an intrauterine fetal death between sixteen weeks and birth, either through spontaneous late miscarriage/stillbirth or termination of pregnancy for medical reasons...
January 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29319210/the-safety-of-quinolones-and-fluoroquinolones-in-pregnancy-a-meta-analysis
#15
Enav Yefet, Naama Schwartz, Bibiana Chazan, Raed Salim, Shabtai Romano, Zohar Nachum
BACKGROUND: Quinolones were contraindicated during pregnancy due to concerns regarding fetal malformations and carcinogenesis in animals. The literature is conflicted regarding their safety in humans. OBJECTIVES: To conducted a meta-analysis evaluating the risk for fetal malformations and pregnancy complications following exposure to quinolones during pregnancy. SEARCH STRATEGY: We searched Embase, PubMed, Medline, the Cochrane database, clinicaltrials...
January 10, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29318613/a-facility-based-study-of-factors-associated-with-perinatal-mortality-in-tigray-northern-ethiopia
#16
Gelila K Goba, Hailesilassie Tsegay, Gebremedhin Berhe, Mengistu Mitiku, Kimberly A Kim, Mussie Alemayehu
OBJECTIVE: To identify perinatal mortality risk factors in the Southern Zone of Tigray, northern Ethiopia. METHODS: The present unmatched case-control study included data from 20 health facilities; stillbirths and neonatal deaths were included as a case group and patients with neonates who survived until discharge or day 7 postpartum were included as a control group. Perinatal mortality risk factors were investigated using bivariate and multivariate logistic regression analyses...
January 9, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29311619/in-situ-immune-response-and-mechanisms-of-cell-damage-in-central-nervous-system-of-fatal-cases-microcephaly-by-zika-virus
#17
Raimunda S S Azevedo, Jorge R de Sousa, Marialva T F Araujo, Arnaldo J Martins Filho, Bianca N de Alcantara, Fernanda M C Araujo, Maria G L Queiroz, Ana C R Cruz, Beatriz H Baldez Vasconcelos, Jannifer O Chiang, Lívia C Martins, Livia M N Casseb, Eliana V da Silva, Valéria L Carvalho, Barbara C Baldez Vasconcelos, Sueli G Rodrigues, Consuelo S Oliveira, Juarez A S Quaresma, Pedro F C Vasconcelos
Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been proposed as ZIKV congenital syndrome. This study aimed to investigate the in situ immune response profile and mechanisms of neuronal cell damage in fatal Zika microcephaly cases. Brain tissue samples were collected from 15 cases, including 10 microcephalic ZIKV-positive neonates with fatal outcome and five neonatal control flavivirus-negative neonates that died due to other causes, but with preserved central nervous system (CNS) architecture...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306181/maternal-race-ethnicity-as-a-risk-factor-for-cervical-insufficiency
#18
Lisette D Tanner, Lue-Yen Tucker, Debbie Postlethwaite, Mara Greenberg
BACKGROUND: Preterm birth (PTB) affects 1 in 9 pregnancies in the United States. There are well known but poorly understood racial/ethnic disparities in PTB rates. The role that racial/ethnic disparities in cervical insufficiency (CI) may play in the overall disparities in preterm birth rates is unknown. OBJECTIVE: The primary objective of this study was to examine racial/ethnic differences in risk of CI. STUDY DESIGN: We conducted a retrospective cohort study of singleton pregnant women in 2012 who were members of Kaiser Permanente Northern California (KPNC), excluding elective termination, delivery outside KPNC, and loss to follow-up...
December 11, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29305138/musk-myasthenia-gravis-and-pregnancy
#19
Ernestina Santos, Antonio Braga, Denis Gabriel, Sara Duarte, Ana Martins da Silva, Ilda Matos, Marta Freijo, Joao Martins, Fernando Silveira, Goreti Nadais, Filipa Sousa, Carla Fraga, Rosa Santos Silva, Carlos Lopes, Guilherme Gonçalves, Clara Pinto, Jorge Sousa Braga, Maria Isabel Leite
Muscle specific kinase (MuSK) myasthenia gravis (MG, MuSK-MG) is a rare subgroup of MG affecting mainly women during childbearing years. We investigated the influence of pregnancy in the course of MuSK-MG and pregnancy outcomes in females with MuSK-MG. A multicentre cohort of 17 women with MuSK-MG was studied retrospectively; 13 of them with ≥1 pregnancy. MuSK-MG onset age was 35,4 years; 23,0% had other autoimmune disorder; 46,2% were treatment refractory. Thirteen women experienced 27 pregnancies, either after MG onset (group I) (n = 4; maternal age at conception = 29...
November 28, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29304545/prenatal-diagnosis-of-congenital-diaphragmatic-hernia-does-laterality-predict-perinatal-outcomes
#20
Jeffrey D Sperling, Teresa N Sparks, Victoria K Berger, Jody A Farrell, Kristen Gosnell, Roberta L Keller, Mary E Norton, Juan M Gonzalez
OBJECTIVE:  The objective of this study was to examine laterality as a predictor of outcomes among fetuses with prenatally diagnosed congenital diaphragmatic hernia (CDH). METHODS:  This is a retrospective cohort study of pregnancies with CDH evaluated at our center from 2008 to 2016 compared cases with right-sided CDH (RCDH) versus left-sided CDH (LCDH). The primary outcome was survival to discharge. Secondary outcomes included ultrasound predictors of poor prognosis (liver herniation, stomach herniation, lung area-to-head circumference ratio [LHR]), concurrent anomalies, hydrops, stillbirth, preterm birth, mode of delivery, small for gestational age, use of extracorporeal membrane oxygenation, and length of stay...
January 5, 2018: American Journal of Perinatology
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