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Bruce e. Mickey

Zhongxu An, Sandeep K Ganji, Vivek Tiwari, Marco C Pinho, Toral Patel, Samuel Barnett, Edward Pan, Bruce E Mickey, Elizabeth A Maher, Changho Choi
PURPOSE: To test the efficacy of triple-refocusing MR spectroscopy (MRS) for improved detection of 2-hydroxyglutarate (2HG) in brain tumors at 3T in vivo. METHODS: The triple-refocusing sequence parameters were tailored at 3T, with density-matrix simulations and phantom validation, for enhancing the 2HG 2.25-ppm signal selectivity with respect to the adjacent resonances of glutamate (Glu), glutamine (Gln), and gamma-aminobutyric acid (GABA). In vivo MRS data were acquired from 15 glioma patients and analyzed with LCModel using calculated basis spectra...
July 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Sandeep K Ganji, Zhongxu An, Vivek Tiwari, Sarah McNeil, Marco C Pinho, Edward Pan, Bruce E Mickey, Elizabeth A Maher, Changho Choi
PURPOSE: To test the efficacy of 7T MRS for in vivo detection of 2-hydroxyglutarate (2HG) in brain tumors. METHODS: The subecho times of point-resolved spectroscopy (PRESS) were optimized at 7T with density-matrix simulations and phantom validation to improve the 2HG signal selectivity with respect to the neighboring resonances of γ-aminobutyric acid (GABA), glutamate (Glu), and glutamine (Gln). MRS data were acquired from 12 subjects with gliomas in vivo and analyzed with LCModel using calculated basis spectra...
March 16, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Zabi Wardak, Alexander Augustyn, Hong Zhu, Bruce E Mickey, Louis A Whitworth, Christopher J Madden, Samuel L Barnett, Ramzi E Abdulrahman, Lucien A Nedzi, Robert D Timmerman, Kevin S Choe
The number of brain metastases identified on diagnostic magnetic resonance imaging (MRI) is a key factor in consideration of stereotactic radiosurgery (SRS). However, additional lesions are often detected on high-resolution SRS-planning MRI. We investigated pre-treatment clinical characteristics that are associated with finding additional metastases at SRS. Patients treated with SRS for brain metastases between the years of 2009-2014 comprised the study cohort. All patients underwent frame-fixed, 1 mm thick MRI on the day of SRS...
June 2016: Journal of Neuro-oncology
Shai M Rozen, Bridget L Harrison, Brandon Isaacson, J Walter Kutz, Peter S Roland, Patricia A Blau, Samuel L Barnett, Bruce E Mickey
BACKGROUND: Reconstructive surgeons may encounter patients presenting after intracranial facial nerve resection and grafting in the setting of skull base tumors, who inquire regarding progression, final facial function, and need for future operations. Study goals were to analyze global and regional facial function using established grading systems and videography, while examine variables possibly affecting outcomes. METHODS: Between 1997 and 2012, 28 patients underwent intracranial nerve grafting...
January 2016: Plastic and Reconstructive Surgery
Timothy E Richardson, Derek A Mathis, Bruce E Mickey, Jack M Raisanen, Dennis K Burns, Charles L White, Kimmo J Hatanpaa
Silent subtype III pituitary adenomas (SS-3) are nonfunctioning radiosensitive adenomas that may be associated with an increased risk of recurrence and invasion. The features that have been proposed to be diagnostically important are identifiable by electron microscopy (EM) and include an enlarged Golgi apparatus, along with several other ultrastructural features. The often limited availability of EM and the uncertainty about the relative importance of individual features pose practical challenges to the diagnosis...
December 2015: Journal of Neuropathology and Experimental Neurology
Elvis Camacho, Melissa A LoPresti, Sam Bruce, Derek Lin, Mickey Abraham, Geoff Appelboom, Blake Taylor, Michael McDowell, Byron DuBois, Mihika Sathe, E Sander Connolly
We aimed to identify the role of age in intracerebral hemorrhage (ICH), as well as characterize the most commonly used age cut off points in the literature, with the hope of understanding and guiding treatment. Strokes are one of the leading causes of death in the USA, and ICH is the deadliest type. Age is a strong risk factor, but it also affects the body in numerous ways, including changes to the cardiovascular and central nervous systems that interplay with the multiple risk factors for ICH. Understanding the role of age in risk and outcomes of ICH can guide treatment and future clinical trials...
December 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Paul Narayan Hein, Bryan Lieber, Eliza Bruce, Blake Taylor, Geoffrey Appelboom, Mickey Abraham, E Sander Connolly
We sought to assess the impact of neoadjuvant therapy on 30 day mortality and morbidity using data from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). Chemotherapy and radiotherapy are both often indicated for treatment of cranial or systemic malignancy but can have significant adverse effects in the postsurgical setting. Data from 2006 to 2012 were obtained from the national ACS-NSQIP database. A total of 1044 patients were identified who obtained surgery for removal of metastatic brain tumors, of whom 127 received neoadjuvant chemotherapy and 65 neoadjuvant radiotherapy...
June 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Tomoyuki Mashimo, Kumar Pichumani, Vamsidhara Vemireddy, Kimmo J Hatanpaa, Dinesh Kumar Singh, Shyam Sirasanagandla, Suraj Nannepaga, Sara G Piccirillo, Zoltan Kovacs, Chan Foong, Zhiguang Huang, Samuel Barnett, Bruce E Mickey, Ralph J DeBerardinis, Benjamin P Tu, Elizabeth A Maher, Robert M Bachoo
Glioblastomas and brain metastases are highly proliferative brain tumors with short survival times. Previously, using (13)C-NMR analysis of brain tumors resected from patients during infusion of (13)C-glucose, we demonstrated that there is robust oxidation of glucose in the citric acid cycle, yet glucose contributes less than 50% of the carbons to the acetyl-CoA pool. Here, we show that primary and metastatic mouse orthotopic brain tumors have the capacity to oxidize [1,2-(13)C]acetate and can do so while simultaneously oxidizing [1,6-(13)C]glucose...
December 18, 2014: Cell
Geoff Appelboom, Elvis Camacho, Mickey E Abraham, Samuel S Bruce, Emmanuel Lp Dumont, Brad E Zacharia, Randy D'Amico, Justin Slomian, Jean Yves Reginster, Olivier Bruyère, E Sander Connolly
BACKGROUND: Innovations in mobile and electronic healthcare are revolutionizing the involvement of both doctors and patients in the modern healthcare system by extending the capabilities of physiological monitoring devices. Despite significant progress within the monitoring device industry, the widespread integration of this technology into medical practice remains limited. The purpose of this review is to summarize the developments and clinical utility of smart wearable body sensors...
2014: Archives of Public Health, Archives Belges de Santé Publique
Koji Sagiyama, Tomoyuki Mashimo, Osamu Togao, Vamsidhara Vemireddy, Kimmo J Hatanpaa, Elizabeth A Maher, Bruce E Mickey, Edward Pan, A Dean Sherry, Robert M Bachoo, Masaya Takahashi
Glioblastoma multiforme (GBM), which account for more than 50% of all gliomas, is among the deadliest of all human cancers. Given the dismal prognosis of GBM, it would be advantageous to identify early biomarkers of a response to therapy to avoid continuing ineffective treatments and to initiate other therapeutic strategies. The present in vivo longitudinal study in an orthotopic mouse model demonstrates quantitative assessment of early treatment response during short-term chemotherapy with temozolomide (TMZ) by amide proton transfer (APT) imaging...
March 25, 2014: Proceedings of the National Academy of Sciences of the United States of America
Bruno C Flores, Benjamin P Boudreaux, Daniel R Klinger, Bruce E Mickey, Samuel L Barnett
Foramen magnum meningiomas (FMMs) are slow growing, most often intradural and extramedullary tumors that pose significant challenges to the skull base neurosurgeon. The indolent clinical course of FMMs and their insidious onset of symptoms are important factors that contribute to delayed diagnosis and relative large size at the time of presentation. Symptoms are often produced by compression of surrounding structures (such as the medulla oblongata, upper cervical spinal cord, lower cranial nerves, and vertebral artery) within a critically confined space...
December 2013: Neurosurgical Focus
Karin Stenberg, Henrik Axelson, Peter Sheehan, Ian Anderson, A Metin Gülmezoglu, Marleen Temmerman, Elizabeth Mason, Howard S Friedman, Zulfiqar A Bhutta, Joy E Lawn, Kim Sweeny, Jim Tulloch, Peter Hansen, Mickey Chopra, Anuradha Gupta, Joshua P Vogel, Mikael Ostergren, Bruce Rasmussen, Carol Levin, Colin Boyle, Shyama Kuruvilla, Marjorie Koblinsky, Neff Walker, Andres de Francisco, Nebojsa Novcic, Carole Presern, Dean Jamison, Flavia Bustreo
A new Global Investment Framework for Women's and Children's Health demonstrates how investment in women's and children's health will secure high health, social, and economic returns. We costed health systems strengthening and six investment packages for: maternal and newborn health, child health, immunisation, family planning, HIV/AIDS, and malaria. Nutrition is a cross-cutting theme. We then used simulation modelling to estimate the health and socioeconomic returns of these investments. Increasing health expenditure by just $5 per person per year up to 2035 in 74 high-burden countries could yield up to nine times that value in economic and social benefits...
April 12, 2014: Lancet
Derek A Mathis, Edward J Stehel, Joseph E Beshay, Bruce E Mickey, Andrew L Folpe, Jack Raisanen
Hypophosphatemia with osteomalacia may be due to a neoplasm that produces fibroblast growth factor 23 (FGF-23), which inhibits phosphate reabsorption in the kidneys. Most of these tumors occur in bone or soft tissue and occasionally in the head, although intracranial occurrence is very rare. This report describes a tumor that caused hypophosphatemia and osteomalacia and was located entirely in the right anterior cranial fossa. Radiologically, the tumor resembled a meningioma; histologically, it was a low-grade phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT)...
April 2013: Journal of Neurosurgery
Isaac Marin-Valencia, Chendong Yang, Tomoyuki Mashimo, Steve Cho, Hyeonman Baek, Xiao-Li Yang, Kartik N Rajagopalan, Melissa Maddie, Vamsidhara Vemireddy, Zhenze Zhao, Ling Cai, Levi Good, Benjamin P Tu, Kimmo J Hatanpaa, Bruce E Mickey, José M Matés, Juan M Pascual, Elizabeth A Maher, Craig R Malloy, Ralph J Deberardinis, Robert M Bachoo
Dysregulated metabolism is a hallmark of cancer cell lines, but little is known about the fate of glucose and other nutrients in tumors growing in their native microenvironment. To study tumor metabolism in vivo, we used an orthotopic mouse model of primary human glioblastoma (GBM). We infused (13)C-labeled nutrients into mice bearing three independent GBM lines, each with a distinct set of mutations. All three lines displayed glycolysis, as expected for aggressive tumors. They also displayed unexpected metabolic complexity, oxidizing glucose via pyruvate dehydrogenase and the citric acid cycle, and using glucose to supply anaplerosis and other biosynthetic activities...
June 6, 2012: Cell Metabolism
Evert A Eriksson, Jeffrey F Barletta, Bryan E Figueroa, Bruce W Bonnell, Chris A Sloffer, Wayne E Vanderkolk, Karen J McAllen, Mickey Ott
BACKGROUND: Utilization of brain tissue oxygenation (pBtO(2)) is an important but controversial variable in the treatment of traumatic brain injury. We hypothesize that pBtO(2) values over the first 72 hours of monitoring are predictive of mortality. METHODS: Consecutive, adult patients with severe traumatic brain injury and pBtO(2) monitors were retrospectively identified. Time-indexed measurements of pBtO(2), cerebral perfusion pressure (CPP), and intracranial pressure (ICP) were collected, and average values over 4-hour blocks were determined...
May 2012: Journal of Trauma and Acute Care Surgery
Elizabeth A Maher, Isaac Marin-Valencia, Robert M Bachoo, Tomoyuki Mashimo, Jack Raisanen, Kimmo J Hatanpaa, Ashish Jindal, F Mark Jeffrey, Changho Choi, Christopher Madden, Dana Mathews, Juan M Pascual, Bruce E Mickey, Craig R Malloy, Ralph J DeBerardinis
Glioblastomas and brain metastases demonstrate avid uptake of 2-[(18) F]fluoro-2-deoxyglucose by positron emission tomography and display perturbations of intracellular metabolite pools by (1) H MRS. These observations suggest that metabolic reprogramming contributes to brain tumor growth in vivo. The Warburg effect, excess metabolism of glucose to lactate in the presence of oxygen, is a hallmark of cancer cells in culture. 2-[(18) F]Fluoro-2-deoxyglucose-positive tumors are assumed to metabolize glucose in a similar manner, with high rates of lactate formation relative to mitochondrial glucose oxidation, but few studies have specifically examined the metabolic fates of glucose in vivo...
November 2012: NMR in Biomedicine
Changho Choi, Sandeep K Ganji, Ralph J DeBerardinis, Kimmo J Hatanpaa, Dinesh Rakheja, Zoltan Kovacs, Xiao-Li Yang, Tomoyuki Mashimo, Jack M Raisanen, Isaac Marin-Valencia, Juan M Pascual, Christopher J Madden, Bruce E Mickey, Craig R Malloy, Robert M Bachoo, Elizabeth A Maher
Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have been shown to be present in most World Health Organization grade 2 and grade 3 gliomas in adults. These mutations are associated with the accumulation of 2-hydroxyglutarate (2HG) in the tumor. Here we report the noninvasive detection of 2HG by proton magnetic resonance spectroscopy (MRS). We developed and optimized the pulse sequence with numerical and phantom analyses for 2HG detection, and we estimated the concentrations of 2HG using spectral fitting in the tumors of 30 subjects...
April 2012: Nature Medicine
Evert A Eriksson, Jeffrey F Barletta, Bryan E Figueroa, Bruce W Bonnell, Wayne E Vanderkolk, Karen J McAllen, Mickey M Ott
OBJECTIVE: Utilization of brain tissue oxygenation (pBtO(2)) is an important but controversial variable in the treatment of traumatic brain injury (TBI). We evaluated the correlation between pBtO(2)/CPP and pBtO(2)/ICP and determined the parameter most closely related to survival. METHODS: Consecutive, adult patients with severe TBI and pBtO(2) monitors were retrospectively identified. Time-indexed measurements of pBtO(2), CPP and ICP were collected and correlation coefficients were determined...
June 2012: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Felicia M T Lewis, Julia A Schillinger, Melanie Taylor, Toye H Brewer, Susan Blank, Tom Mickey, Bruce W Furness, Greta L Anschuetz, Melinda E Salmon, Thomas A Peterman
BACKGROUND: Screening for syphilis has been performed for decades, but it is unclear if the practice yields many cases at acceptable cost, and if so, at which venues. We attempted a retrospective study to determine the costs, yield, and feasibility of analyzing health department-funded syphilis outreach screening in 5 diverse US sites with significant disease burdens. METHODS: Data (venue, costs, number of tests, reactive tests, new diagnoses) from 2000 to 2007 were collected for screening efforts funded by public health departments from Philadelphia; New York City; Washington, District of Columbia; Maricopa County, Arizona (Phoenix); and the state of Florida...
November 2011: Journal of Public Health Management and Practice: JPHMP
Gregory S Simmons, Andrew R McKemey, Neil I Morrison, Sinead O'Connell, Bruce E Tabashnik, John Claus, Guoliang Fu, Guolei Tang, Mickey Sledge, Adam S Walker, Caroline E Phillips, Ernie D Miller, Robert I Rose, Robert T Staten, Christl A Donnelly, Luke Alphey
Pest insects harm crops, livestock and human health, either directly or by acting as vectors of disease. The Sterile Insect Technique (SIT)--mass-release of sterile insects to mate with, and thereby control, their wild counterparts--has been used successfully for decades to control several pest species, including pink bollworm, a lepidopteran pest of cotton. Although it has been suggested that genetic engineering of pest insects provides potential improvements, there is uncertainty regarding its impact on their field performance...
2011: PloS One
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