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https://www.readbyqxmd.com/read/29667926/proximal-tibia-stress-fracture-with-osteoarthritis-of-knee-radiological-and-functional-analysis-of-one-stage-tka-with-long-stem
#1
Dhanasekaran Soundarrajan, Natesan Rajkumar, Palanisamy Dhanasekararaja, Shanmuganathan Rajasekaran
INTRODUCTION: Proximal tibia stress fractures with knee osteoarthritis pose a challenging situation. We evaluated the radiological and functional outcome of one-stage total knee arthroplasty (TKA) and long stem for patients with varied grades of knee arthritis and proximal tibia stress fractures.  Methods: We analysed 20 patients from April 2012 to March 2017 with proximal tibia stress fractures associated with knee osteoarthritis of varied grades. Out of 20 patients, five were acute fresh fractures...
2018: SICOT-J
https://www.readbyqxmd.com/read/29667639/-a-change-in-the-direction-of-the-wound-channel-in-the-case-of-the-combined-injury-inflicted-by-a-shot-from-the-9-0-mm-makarov-pistol
#2
A A Gusarov, I Yu Makarov, V A Fetisov
The authors present an example from the expert practice demonstrating the influence of such factors as the properties of the ammunition fired from a weapon (including its weight, size, shape, and speed) as well as the anatomical features of the body tissues being affected on the mechanism of formation of a gunshot wound in the human body. The investigation of the suicide of subject P. has demonstrated the penetrating bullet wound of the neck and the head. The entrance wound was located at the anterior neck surface and the exit one in the left half of the occipital region...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667471/cost-effectiveness-analysis-of-suvorexant-for-the-treatment-of-japanese-elderly-patients-with-chronic-insnomnia-in-a-virtual-cohort
#3
Shinichi Nishimura, Mutsuhiro Nakao
AIMS: We assessed the cost effectiveness of the orexin receptor antagonist suvorexant against zolpidem, the most widely used hypnotic benzodiazepine receptor agonist in Japan. To this end, a model was used that factored in insomnia and the risk for hip fractures, which have devastating effects on the elderly. METHODS: Data were derived from published papers. The target population was a virtual cohort of elderly patients (≥65 years) with insomnia residing in Japan...
April 18, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29667227/effects-of-knockout-of-the-receptor-for-advanced-glycation-end-products-on-bone-mineral-density-and-synovitis-in-mice-with-intra-articular-fractures
#4
Dongrim Seol, Yuki Tochigi, Ashley M Bogner, Ino Song, Douglas C Fredericks, Gail L Kurriger, Sonja M Smith, Jessica E Goetz, Joseph A Buckwalter, James A Martin
Our group employed the mouse closed intra-articular fracture (IAF) model to test the hypothesis that the innate immune system plays a role in initiating synovitis and post-traumatic osteoarthritis (PTOA) in fractured joints. A transgenic strategy featuring knockout of the receptor for advanced glycation end-products (RAGE -/- ) was pursued. The 42 and 84 mJ impacts used to create fractures were in the range previously reported to cause PTOA at 60 days post-fracture. MicroCT (µCT) was used to assess fracture patterns and epiphyseal and metaphyseal bone loss at 30 and 60 days post-fracture...
April 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29667153/supplemented-amino-acids-may-enhance-the-walking-recovery-of-elderly-subjects-after-hip-fracture-surgery
#5
Roberto Aquilani, Carlo Zuccarelli Ginetto, Carla Rutili, Pietro Pisano, Evasio Pasini, Eleonora Baldissarro, Manuela Verri, Federica Boschi
The purpose of this study was to investigate whether supplemented essential amino acids (EAAs) could enhance rehabilitation therapy (Rehab) for recovery of walking capacity in subjects after hip fracture surgery (HFS). Eighty-three elderly subjects with HFS (20 ± 11 days after acute trauma) were eligible for the study and randomized to receive Rehab only (Rehab; n = 27), Rehab + placebo (RP; n = 28) or Rehab + EAAs (RE 8 g/day; n = 28). The patients' walking capacity (m) was measured by 6-min walking distance (6MWD) at admission and at discharge (median 66 days after admission)...
April 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29667152/falls-in-mexican-older-adults-aged-60-years-and-older
#6
Luis M Valderrama-Hinds, Soham Al Snih, Nai-Wei Chen, Martin A Rodriguez, Rebeca Wong
BACKGROUND: Falls are a major cause of disability, morbidity, institutionalization, and mortality in older adults. OBJECTIVES: The purpose of the study was to examine the risk factors for falls among Mexican older adults aged 60 years and older. METHODS: This study included 6247 participants and their spouse or partner aged 60 years and older from the Mexican Health and Aging Study, an ongoing longitudinal study (2001-2012) conducted in Mexico...
April 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29667007/failure-in-diagnosis-and-under-treatment-of-osteoporosis-in-elderly-patients-with-fragility-fractures
#7
Sofia Bougioukli, Panagoula Κollia, Theodora Koromila, Sokratis Varitimidis, Michael Hantes, Theofilos Karachalios, Κonstantinos Ν Malizos, Zoe H Dailiana
We evaluated whether osteoporosis is adequately managed and treated in patients suffering from fragility fractures. Factors that influenced osteoporosis diagnosis and treatment rates were also assessed. To this end, patients with the principal diagnosis of low-energy hip, vertebral, or distal radius fractures were recruited for the study. Collected data included risk factors for osteoporosis, history of previous fractures, known history of osteoporosis, and osteoporosis treatment at the time of admission. The patients' prefracture risk profile was also assessed to determine whether osteoporosis could have been identified prior to the index fracture...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29667005/the-bmp-2-mutant-l51p-a-bmp-receptor-ia-binding-deficient-inhibitor-of-noggin
#8
REVIEW
Hany Mohamed Khattab, Satoshi Kubota, Masaharu Takigawa, Takuo Kuboki, Walter Sebald
The antagonist-specific regulation in tissue engineering constitutes important attempts to achieve an improved and rapid bone regeneration by controlling the natural biological response of the natural body growth factors. L51P is molecularly engineered bone morphogentic protein-2 (BMP-2) variant with a substitution of the 51st leucine with a proline residue. L51P is deficient in BMP receptor binding, but maintains its structure and affinity for inhibitory proteins such as noggin, chordin, and gremlin. These modifications convert the BMP-2 variant L51P into a receptor-inactive inhibitor of BMP antagonists...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29666948/epidemiology-of-hip-fracture-in-belarus-development-of-a-country-specific-frax-model-and-its-comparison-to-neighboring-country-models
#9
H Ramanau, I Chernyanin, E Rudenka, O Lesnyak, A Zakroyeva, J P Bilezikian, H Johansson, N C Harvey, E V McCloskey, J A Kanis
Fracture probabilities resulting from the newly generated FRAX model for Belarus based on regional estimates of the hip fracture incidence were compared with FRAX models of neighboring countries. Differences between the country-specific FRAX patterns and the rank orders of fracture probabilities were modest. OBJECTIVE: This paper describes the epidemiology of hip fractures in Belarus that was used to develop the country-specific fracture prediction FRAX® tool and illustrates its features compared to models for the neighboring countries of Poland, Russia, and Lithuania...
April 17, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29666919/prevalence-of-vitamin-d-insufficiency-and-evidence-for-disease-prevention-in-the-older-population
#10
REVIEW
Julia Kühn, Paula Trotz, Gabriele I Stangl
The prevalence of vitamin D insufficiency, usually assessed by the analysis of circulating 25-hydroxyvitamin D (25[OH])D), is very high in the aging German population. An important factor that reduces endogenous vitamin D synthesis in older persons is physical inactivity or care-dependency that limits the time spent outside. Additionally, it has been suggested that the age-dependent decline in the glomerular filtration rate is associated with a reduced production of bioactive calcitriol. As this phenomenon is not detectable by the assessment of 25(OH)D, it is necessary to analyze the level of parathyroid hormone as a marker of calcitriol function...
April 17, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29666736/intra-articular-entrapment-of-the-medial-epicondyle-following-a-traumatic-fracture-dislocation-of-the-elbow-in-an-adult
#11
Hicham G Abdel Nour, George S El Rassi, Jack C Daoud, Youssef G Hassan, Rami A Ayoubi, Nabih I Joukhadar
Medial epicondyle entrapment after an acute fracture dislocation of the elbow is a common finding in the pediatric population, but a rare finding in adults. We present a case of an adult patient diagnosed with a traumatic fracture dislocation of the elbow joint with intra-articular entrapment of the medial epicondyle. After initial evaluation, closed reduction was done. Stability testing after reduction showed an unstable joint; thus, open reduction and internal fixation was decided.
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29666734/open-reduction-and-internal-fixation-of-a-proximal-femoral-shaft-fracture-in-a-patient-with-bilateral-congenital-hip-disease
#12
Stefania Kanata, Antonios Anastasiadis
We present a rare case of a femoral shaft fracture in a 74-year-old woman with a preexisting untreated bilateral congenital hip dislocation and with concomitant leg length discrepancy. Because of the marked deformity of the upper femur, a derivative of the congenital hip disease, an open reduction and internal fixation was performed, with the use of an anatomic femur plate originally designed for the treatment of periprosthetic fractures. The patient was treated successfully and returned to her previous status of activity...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29666603/long-term-factors-associated-with-falls-and-fractures-poststroke
#13
Emma J Foster, Raphae S Barlas, Joao H Bettencourt-Silva, Allan B Clark, Anthony K Metcalf, Kristian M Bowles, John F Potter, Phyo K Myint
Background: Risk factors for poststroke falls and fractures remain poorly understood. This study aimed to evaluate which factors increased risk of these events after stroke. Methods: Data from 7,267 hospitalized stroke patients were acquired from the Norfolk and Norwich University Hospital Stroke Register from 2003-2015. The impacts of multiple patient level and stroke characteristics and comorbidities on post-discharge falls and fractures were assessed. Univariate and multivariable models were constructed, adjusting for multiple confounders, using binary logistic regression for short-term analysis (up to 1-year post-discharge) and Cox-proportional hazard models for longer term analysis (1-3, 3-5, and 0-10 years follow-up)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29666099/collapse-in-the-elderly-rivastigmine-induced-heart-block-and-a-literature-review-of-the-pharmacology-of-acetylcholinesterase-inhibitors-used-in-alzheimer-s-disease
#14
Olushola Alonge, Fahad Mujtaba Iqbal, Elzbieta Cifonelli
Falls resulting in neck of femur fractures are common in the elderly. Often multiple comorbidities can make management and diagnosis of such a polyfactorial condition difficult, particularly with Alzheimer's dementia (AD). Indeed, poorly managed AD may contribute to falls. We present our management of an 87-year-old woman, on rivastigmine for AD, who presented with a collapse episode-attributed to rivastigmine-resulting in a neck of femur fracture. Furthermore, we perform a literature review of the pharmacology of acetylcholinesterase inhibitors and how their use in AD may contribute to bradyarrhythmias...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29666087/conservative-treatment-in-displaced-fractures-of-the-humeral-capitellum-a-reduction-technique-under-local-anaesthesia
#15
Takahisa Ogawa, Shinichi Shirasawa
We report the case of a 46-year-old woman who struck her right elbow on the ground after a fall on ice. Radiography showed a right humeral capitellar fracture, and CT further confirmed a Dubberley type 1A fracture. Closed reduction was performed under local anaesthesia, and an anatomical position was obtained. After the reduction, her right elbow was casted for 18 days. Three months after the injury, bone union was achieved without displacement, and the active range of motion of her right elbow recovered similar to the unaffected side...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29666001/distal-tibial-triplane-fracture-with-ipsilateral-tibial-shaft-fracture-a-case-series
#16
Timothy S Holland, Christopher P Prior, Roger Dm Walton
BACKGROUND & PURPOSE: Distal tibial Triplane fracture with ipsilateral tibial shaft fracture is a rare but important problem. This rarely reported combination of injuries if not recognised may lead to deleterious consequences. METHODS/PATIENTS: The local database of all emergency admissions was scrutinised to identify subjects before interrogation of the clinical notes and relevant radiographic imaging. FINDINGS: This paper reports a series of five children who were found to have triplane fracture of the distal tibia with concomitant ipsilateral fracture of the tibial shaft...
April 14, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29665839/the-efficiency-of-risedronate-in-reducing-bone-resorption-after-total-hip-arthroplasty-a-meta-analysis-of-randomized-control-trials-at-a-minimum-of-6-months-follow-up
#17
Liqing Yang
BACKGROUND: Recently risedronate is suggested to be effective for the prevention and treatment of for osteoporosis in total hip arthroplasty. This meta-analysis aimes to evaluate the efficacy of risedronate in reducing femoral periprosthetic bone mineral density loss in patients undergoing primary total hip arthroplasty. METHODS: A systematic search was performed in Medline (1966-31 October 2017), PubMed (1966-31 October 2017), Embase (1980-31 October 2017), ScienceDirect (1985-31 October 2017) and the Cochrane Library...
April 17, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29665749/early-and-mid-term-results-in-the-endovascular-treatment-of-popliteal-aneurysms-with-the-multilayer-flow-modulator
#18
Alessandro Ucci, Ruggiero Curci, Matteo Azzarone, Claudio Bianchini Massoni, Antonio Bozzani, Carla Marcato, Enrico Maria Marone, Paolo Perini, Tiziano Tecchio, Antonio Freyrie, Angelo Argenteri
Background The endovascular approach became an alternative to open surgical treatment of popliteal artery aneurysm over the last few years. Heparin-bonded stent-grafts have been employed for endovascular popliteal artery aneurysm repair, showing good and stable results. Only few reports about the use of multilayer flow modulator are available in literature, providing small patient series and short follow-up. The aim of this study is to report the outcomes of patients with popliteal artery aneurysm treated with the multilayer flow modulator in three Italian centres...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29665704/low-dose-ct-of-postoperative-pelvic-fractures-a-comparison-with-radiography
#19
Thomas Eriksson, Per Berg, Claes Olerud, Adel Shalabi, Mari Hänni
Background Computed tomography (CT) is superior to conventional radiography (CR) for assessing internal fixation of pelvic fractures, but with a higher radiation exposure. Low-dose CT (LDCT) could possibly have a sufficient diagnostic accuracy but with a lower radiation dose. Purpose To compare postoperative diagnostic accuracy of LDCT and CR after open reduction and internal fixation of pelvic fracture. Material and Methods Twenty-one patients were examined with LDCT and CR 0-9 days after surgery. The examinations were reviewed by two musculoskeletal radiologists...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29665618/pseudo-and-conditional-score-approach-to-joint-analysis-of-current-count-and-current-status-data
#20
Chi-Chung Wen, Yi-Hau Chen
We develop a joint analysis approach for recurrent and nonrecurrent event processes subject to case I interval censorship, which are also known in literature as current count and current status data, respectively. We use a shared frailty to link the recurrent and nonrecurrent event processes, while leaving the distribution of the frailty fully unspecified. Conditional on the frailty, the recurrent event is assumed to follow a nonhomogeneous Poisson process, and the mean function of the recurrent event and the survival function of the nonrecurrent event are assumed to follow some general form of semiparametric transformation models...
April 17, 2018: Biometrics
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