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https://www.readbyqxmd.com/read/28823022/long-term-bisphosphonate-therapy-in-osteogenesis-imperfecta
#1
REVIEW
A Biggin, C F Munns
PURPOSE OF REVIEW: Osteogenesis imperfecta (OI) is a genetic bone disorder resulting in bone fragility. It has a heterogeneous phenotype which typically includes reduced bone mass, multiple fractures, deformity, and chronic disability. Bisphosphonate treatment remains the first-line medical management, but there is still debate on aspects of its effectiveness. This review summarizes current knowledge about long-term bisphosphonate use in OI with recommendations on clinical application...
August 19, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28822998/spontaneous-shrinkage-of-solitary-osteochondromas
#2
Hisaki Aiba, Satoshi Yamada, Norio Yamamoto, Katsuhiro Hayashi, Shinji Miwa, Hiroyuki Tsuchiya, Takanobu Otsuka
OBJECTIVE: Osteochondromas are the most common benign bone tumors, and thus far, their spontaneous shrinkage is considered a rare phenomenon. This study was designed to investigate the exact ratio of remission to progressive or stable cases and analyze the mechanism of tumor regression on the basis of existing theories. MATERIALS AND METHODS: We retrospectively collected images of solitary osteochondromas in patients from 1992 to 2013, excluding cases involving short-term follow-up periods and follow-up periods that ended before growth plate closure...
August 19, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28822791/acute-unilateral-hip-pain-in-fibrodysplasia-ossificans-progressiva-fop
#3
Frederick S Kaplan, Mona Al Mukaddam, Robert J Pignolo
BACKGROUND: Flare-ups of the hips are among the most feared and disabling complications of fibrodysplasia ossificans progressiva (FOP) and are poorly understood. In order to better understand the nature of hip flare-ups in FOP, we evaluated 25 consecutive individuals with classic FOP (14 males, 11 females; 3-56years old, median age, 17years old) who presented with acute unilateral hip pain. RESULTS: All 25 individuals were suspected of having a flare-up of the hip based on clinical history and a favorable response to a four day course of high-dose oral prednisone...
August 16, 2017: Bone
https://www.readbyqxmd.com/read/28822737/printing-nature-unraveling-the-role-of-nacre-s-mineral-bridges
#4
Grace X Gu, Flavia Libonati, Susan D Wettermark, Markus J Buehler
Creating materials with strength and toughness has been a long-sought goal. Conventional engineering materials often face a trade-off between strength and toughness, prompting researchers seeking to overcome these limitations to explore more sophisticated materials, such as composites. This paradigm shift in material design is spurred by nature, which exhibits a plethora of heterogeneous materials that offer outstanding material properties, and many natural materials are widely regarded as examples of high-performing hybrid materials...
May 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28822375/novel-management-for-distal-radius-fracture-after-trauma
#5
Bryan Brown, Kenneth Koval, Joshua Langford, Indermeet S Bhullar
No abstract text is available yet for this article.
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822360/the-role-of-diverting-colostomy-in-traumatic-blunt-open-pelvic-fractures
#6
Caitlin A Fitzgerald, Thomas J Moore, Bryan C Morse, Anuradha Subramanian, Christopher J Dente, Dipan C Patel, William M Reisman, Mara L Schenker, Rondi B Gelbard
No abstract text is available yet for this article.
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28821231/novel-mutations-in-pank2-and-pla2g6-genes-in-patients-with-neurodegenerative-disorders-two-case-reports
#7
Hassan Dastsooz, Hamid Nemati, Mohammad Ali Farazi Fard, Majid Fardaei, Mohammad Ali Faghihi
BACKGROUND: Neurodegeneration with brain iron accumulation (NBIA) is a genetically heterogeneous group of disorders associated with progressive impairment of movement, vision, and cognition. The disease is initially diagnosed on the basis of changes in brain magnetic resonance imaging which indicate an abnormal brain iron accumulation in the basal ganglia. However, the diagnosis of specific types should be based on both clinical findings and molecular genetic testing for genes associated with different types of NBIA, including PANK2, PLA2G6, C19orf12, FA2H, ATP13A2, WDR45, COASY, FTL, CP, and DCAF17...
August 18, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28822222/biomechanical-comparison-of-a-novel-monocortical-and-two-common-bicortical-external-fixation-systems-regarding-rigidity-and-dynamic-stability
#8
Patrick A Varady, Markus Greinwald, Peter Augat
AIM: To biomechanically compare a monocortical single frame external fixator (Orthofix UNYCO) with two bicortical fixator systems (dual frame: Stryker Hoffmann and single frame: Synthes LEF) with respect to system rigidity and stability under cyclic loading. METHODS: The fixator systems were assessed for axial rigidity under loads which would occur clinically during fixator application and dynamic stability (cyclic fatigue) under loads which would occur in the first week postoperatively...
August 19, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28821936/minimally-invasive-plate-augmentation-in-the-treatment-of-long-bone-non-unions
#9
Ki-Chul Park, Chang-Wug Oh, Joon-Woo Kim, Kyeong-Hyeon Park, Jong-Keon Oh, Il-Hyung Park, Hee-Soo Kyung, Jeong Heo
INTRODUCTION: Exchange nailing is most acceptable for treating hypertrophic non-union of the long bones, requiring the removal of previously fixed implant. However, its main effect of mechanical stabilization is controversial in non-isthmal area. We hypothesized that minimally invasive plate augmentation over the non-union site may have a better option, without the need of bone grafting or removing pre-existing implants. MATERIALS AND METHODS: Seventeen patients with hypertrophic non-union of the long bones between 2010 and 2014 on radiography who previously underwent intramedullary (IM) nailing or plate osteosynthesis for long-bone fractures were included...
August 18, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28821915/risk-and-outcomes-of-fracture-in-peripheral-arterial-disease-patients-two-nationwide-cohort-studies
#10
F-L Liu, C-S Lin, C-C Yeh, C-C Shih, Y-G Cherng, C-H Wu, T-L Chen, C-C Liao
Using national insurance claims data of Taiwan, we found that patients with peripheral arterial disease (PAD) had increased risk of fracture during the follow-up period of 2000-2013. History of PAD was also associated with adverse outcomes in hospitalized fracture patients. Prevention strategies were needed in this susceptible population. INTRODUCTION: Limited information was available on the association between PAD and fracture. The purpose of this study is to evaluate fracture risk and post-fracture outcomes in patients with PAD...
August 18, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28821906/comparing-pain-reduction-following-kyphoplasty-and-vertebroplasty-a-meta-analysis-of-randomized-and-non-randomized-controlled-trials
#11
Chen Chen, Xiaofeng Shen, Jiangping Wang, Zhigang Zhang, Yuwei Li, Hua Chen
PURPOSE: The aim of the study was to compare the extent of pain reduction with kyphoplasty (KP) and vertebroplasty (VP) in the treatment of osteoporotic vertebral compression fractures (OVCF) using a visual analog scale (VAS). METHODS: A computerized database search was performed to compare pain relief from VP and KP in OVCF. The available literature was analysed to quantify the amount of pain reduction using VAS as the primary outcome. RESULTS: A total of 10 studies encompassing 902 patients met the inclusion criteria...
August 18, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28821502/overweight-and-obese-children-do-not-consult-their-general-practitioner-more-often-than-normal-weight-children-for-musculoskeletal-complaints-during-a-2-year-follow-up
#12
Janneke van Leeuwen, Marienke van Middelkoop, Winifred D Paulis, Herman J Bueving, Patrick J E Bindels, Bart W Koes
BACKGROUND: Childhood obesity is associated with self-reported musculoskeletal complaints, injuries and fractures. In the current study, we investigated the association between weight status of children and the frequency and type of musculoskeletal consultations at the general practitioner (GP) during a 2-year follow-up. METHODS: Data from a prospective longitudinal cohort study including children aged 2-18 years presenting in general practices in the Netherlands were used...
August 18, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28821456/hyperglycemia-is-associated-with-increased-bone-mineral-density-and-decreased-trabecular-bone-score-in-elderly-japanese-men-the-fujiwara-kyo-osteoporosis-risk-in-men-formen-study
#13
Masayuki Iki, Yuki Fujita, Katsuyasu Kouda, Akiko Yura, Takahiro Tachiki, Junko Tamaki, Renaud Winzenrieth, Yuho Sato, Jong-Seong Moon, Nozomi Okamoto, Norio Kurumatani
PURPOSE: Patients with type 2 diabetes mellitus (T2DM) have an increased fracture risk despite having higher areal bone mineral density (aBMD). This study aimed to clarify the association between glycemic and insulin resistance status and bone microarchitecture, and whether pentosidine and bone turnover markers play any roles in the association. METHODS: A total of 2012 community-dwelling men aged ≥65years completed baseline measurements of spine aBMD, fasting plasma glucose (FPG) and serum insulin, hemoglobin A1c (HbA1c), osteocalcin, type I procollagen N-terminal propeptide, type I collagen C-terminal crosslinking telopeptide, tartrate-resistant acid phosphatase isoenzyme 5b, pentosidine, height and weight and an interview regarding past disease history...
August 15, 2017: Bone
https://www.readbyqxmd.com/read/28821134/graphene-cyclodextrin-based-nanocomposite-hydrogel-with-enhanced-strength-and-thermo-responsive-ability
#14
Pang Zhu, Yonghong Deng, Chaoyang Wang
Dual crosslinked system has been proved to be an efficient method to obtain tough and high strength hydrogels. Herein, we synthesized a novel graphene oxide/p(acrylamide-co-poly(ethylene glycol) methyl ether methacrylate)/α-cyclodextrin (GO/P(AM-co-PEGMA)/CD) physical dual crosslinked hydrogel via copolymerization of AM and PEGMA in the α-CD/GO solution. The polymer main chains adsorb onto the GO surface resulting in the first crosslinked system and multiple hydrogen bonds between α-CDs that thread on the PEGMA side chains establish the second crosslinked system...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820570/engineering-of-micro-to-nano-structured-3d-printed-drug-releasing-titanium-implants-for-enhanced-osseointegration-and-localized-delivery-of-anticancer-drugs
#15
Shaheer Maher, Gagandeep Kaur, Luis Lima-Marques, Andreas Evdokiou, Dusan Losic
Primary and secondary bone cancers are major causes of pathological bone fractures and their treatment through implant fixation and conventional chemotherapy has many limitations. These implants may suffer from poor osseointegration and their rejection is causing repeated surgery, patient's suffering and extensive expenses. On the other hand, there are severe systemic adverse effects of toxic chemotherapeutics administrated using conventional drug delivery. In this paper to address these two problems we present new type of localized drug-releasing titanium implants with enhanced implants' bio-integration and drug release capabilities that could provide high concentration of toxic anticancer drugs locally to treat bone cancers...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28820364/patterns-of-c-2-fracture-in-the-elderly-comparison-of-etiology-treatment-and-mortality-among-specific-fracture-types
#16
Ingrid Radovanovic, Jennifer C Urquhart, Parham Rasoulinejad, Kevin R Gurr, Fawaz Siddiqi, Christopher S Bailey
OBJECTIVE Previous studies have focused on Type II odontoid fractures and have failed to report on the effect of other C-2 fracture types on treatment and outcome. The purpose of this study was to compare patient characteristics, cause of injury, predisposing factors to fracture, treatments, and mortality rates among C-2 fracture types in a cohort of elderly patients 70 years of age and older. METHODS A retrospective cohort study design was used. Patients who sustained a C-2 fracture between 2002 and 2011 and who were admitted to the authors' Level 1 trauma center were identified using the Discharge Abstract Database and the International Statistical Classification of Diseases and Related Health Problems (ICD-10) code S12...
August 18, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28820180/osteogenesis-imperfecta
#17
REVIEW
Joan C Marini, Antonella Forlino, Hans Peter Bächinger, Nick J Bishop, Peter H Byers, Anne De Paepe, Francois Fassier, Nadja Fratzl-Zelman, Kenneth M Kozloff, Deborah Krakow, Kathleen Montpetit, Oliver Semler
Skeletal deformity and bone fragility are the hallmarks of the brittle bone dysplasia osteogenesis imperfecta. The diagnosis of osteogenesis imperfecta usually depends on family history and clinical presentation characterized by a fracture (or fractures) during the prenatal period, at birth or in early childhood; genetic tests can confirm diagnosis. Osteogenesis imperfecta is caused by dominant autosomal mutations in the type I collagen coding genes (COL1A1 and COL1A2) in about 85% of individuals, affecting collagen quantity or structure...
August 18, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28820172/timing-of-surgery-in-traumatic-globe-dislocation
#18
Md Shahid Alam, Olma Veena Noronha, Bipasha Mukherjee
Traumatic globe dislocation into the maxillary sinus is a rare event and usually associated with a poor visual outcome if not managed appropriately. We report a 45-year-old female patient who presented to the emergency after blunt injury to her face with a door. Initial evaluation revealed nil perception of light and an apparently anophthalmic socket. Neuroimaging revealed large floor and medial wall fracture with dislocation of the globe into the maxillary sinus. The patient underwent exploration with repositioning of the globe and fracture repair...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28819829/surgical-treatment-for-symptomatic-non-ossifying-fibromas-of-the-lower-extremity-with-calcium-sulfate-grafts-in-skeletally-immature-patients
#19
Antonio Andreacchio, Flavia Alberghina, Gianluca Testa, Federico Canavese
BACKGROUND: Non-ossifying fibromas (NOFs) are common benign bone lesions found in children and adolescents. They usually involve metaphysis of long bones, tend to gradually disappear with age and usually do not require surgery, while they are not associated with pathological fractures. The aim of this study was to evaluate the outcome and efficacy of a single-stage procedure, comprising curettage of the lesion and calcium sulfate pellet (CaSP) grafting, in skeletally immature patients with large, symptomatic NOF of the lower extremity, and the possible limitations of the procedure...
August 17, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28819815/-pediatric-finger-and-hand-injuries-an-epidemiological-study
#20
M Voth, Th Lustenberger, J Frank, I Marzi
BACKGROUND: The hand is the second most frequently injured region of the body in children. The aim of this study was to evaluate age-related injury patterns, trauma mechanisms, as well as the need for surgery in pediatric patients with injuries to the hand. PATIENTS AND METHODS: This was a retrospective study analyzing the data between January 2008 and December 2014 at Frankfurt University Hospital. All patients were younger than 18 years old. All patients suffering trauma to the hand or the fingers were included...
August 17, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
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