Muhammed Shariff, Aksharkumar Dobariya, Obada Albaghdadi, Jacob Awkal, Hadi Moussa, Gabriel Reyes, Mansur Syed, Robert Hart, Cameron Longfellow, Debra Douglass, Tarek Y El Ahmadieh, Levi B Good, Vikram Jakkamsetti, Gauri Kathote, Gus Angulo, Qian Ma, Ronnie Brown, Misha Dunbar, John M Shelton, Bret M Evers, Sourav Patnaik, Ulrike Hoffmann, Amy E Hackmann, Bruce Mickey, Matthias Peltz, Michael E Jessen, Juan M Pascual
Selective vascular access to the brain is desirable in metabolic tracer, pharmacological and other studies aimed to characterize neural properties in isolation from somatic influences from chest, abdomen or limbs. However, current methods for artificial control of cerebral circulation can abolish pulsatility-dependent vascular signaling or neural network phenomena such as the electrocorticogram even while preserving individual neuronal activity. Thus, we set out to mechanically render cerebral hemodynamics fully regulable to replicate or modify native pig brain perfusion...
August 25, 2023: Scientific Reports