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Tropomyosin

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https://www.readbyqxmd.com/read/28440712/gelatin-albumin-hybrid-nanoparticles-as-matrix-metalloproteinases-degradable-delivery-systems-for-breast-cancer-therapy
#1
Vahid Heravi Shargh, Hubert Hondermarck, Mingtao Liang
AIM: To develop matrix metalloproteinase-responsive gelatin-albumin hybrid nanoparticles encapsulating a selective tropomyosin receptor kinase A (TrkA) inhibitor GNF-5837 (Gel-Alb-GNF HNPs) and to demonstrate their anticancer effects in breast cancer. METHODS: Gel-Alb-GNF HNPs were prepared using a pH-controlled complexation process from cationic gelatin, dextran sulfate and albumin-bound GNF-5837. The anticancer activities of Gel-Alb-GNF HNPs were tested in a panel of subtype-specific breast cancer cell lines...
April 25, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28434865/allergens-involved-in-the-cross-reactivity-of-aedes-aegypti-with-other-arthropods
#2
Jose Fernando Cantillo, Leonardo Puerta, Sylvie Lafosse-Marin, Jose Luis Subiza, Luis Caraballo, Enrique Fernandez-Caldas
BACKGROUND: Cross-reactivity between Aedes aegypti and mites, cockroaches, and shrimp has been previously suggested, but the involved molecular components have not been fully described. OBJECTIVE: To evaluate the cross-reactivity between A aegypti and other arthropods. METHODS: Thirty-four serum samples from patients with asthma and/or allergic rhinitis were selected, and specific IgE to A aegypti, Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis, Periplaneta americana...
April 20, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28433463/actin-regulation-by-tropomodulin-and-tropomyosin-in-neuronal-morphogenesis-and-function
#3
REVIEW
Kevin T Gray, Alla S Kostyukova, Thomas Fath
Actin is a profoundly influential protein; it impacts, among other processes, membrane morphology, cellular motility, and vesicle transport. Actin can polymerize into long filaments that push on membranes and provide support for intracellular transport. Actin filaments have polar ends: the fast-growing (barbed) end and the slow-growing (pointed) end. Depolymerization from the pointed end supplies monomers for further polymerization at the barbed end. Tropomodulins (Tmods) cap pointed ends by binding onto actin and tropomyosins (Tpms)...
April 19, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28431393/loss-of-tpm4-1-leads-to-disruption-of-cell-cell-adhesions-and-invasive-behavior-in-breast-epithelial-cells-via-increased-rac1-signaling
#4
SukYeong Jeong, SunYoung Lim, Galina Schevzov, Peter W Gunning, David M Helfman
Here we report the identification and characterization of a novel high molecular weight isoform of tropomyosin, Tpm4.1, expressed from the human TPM4 gene. Tpm4.1 expression is down-regulated in a subset of breast cancer cells compared with untransformed MCF10A breast epithelial cells and in highly metastatic breast cancer cell lines derived from poorly metastatic MDA-MD-231 cells. In addition, patients with invasive ductal breast carcinoma show decreased TPM4 expression compared with patients with ductal breast carcinoma in situ, and low TPM4 expression is associated with poor prognosis...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423707/tropomyosin-related-kinase-b-mediated-signaling-contributes-to-the-induction-of-malignant-phenotype-of-gallbladder-cancer
#5
Makoto Kawamoto, Hideya Onishi, Keigo Ozono, Akio Yamasaki, Akira Imaizumi, Sachiko Kamakura, Kenji Nakano, Yoshinao Oda, Hideki Sumimoto, Masafumi Nakamura
This study aims to demonstrate the clinical and biological significance of Brain derived neurotrophic factor (BDNF)/Tropomyosin-related kinase B (TrkB) signaling in gallbladder cancer (GBC) through a series of in vitro and in vivo experiments. TrkB expression was detected in 63 (91.3%) out of 69 surgically resected primary GBC specimens by immunohistochemistry. TrkB expression in the invasive front correlated with T factor (p=0.0391) and clinical staging (p=0.0391). Overall survival was lower in patients with high TrkB expression in the invasive front than in those with low TrkB expression (p=0...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417199/intake-of-7-8-dihydroxyflavone-from-pregnancy-to-weaning-prevents-cognitive-deficits-in-adult-offspring-after-maternal-immune-activation
#6
Mei Han, Ji-Chun Zhang, Xu-Feng Huang, Kenji Hashimoto
Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the brain neurodevelopment. The exposure of pregnant mice to polyinosinic-polycytidylic acid [poly(I:C)] causes cognitive deficits in adult offspring. Supplementation with a TrkB agonist, 7,8-dihydroxyflavone, in poly(I:C)-treated pregnant mice from pregnancy to weaning could prevent the onset of cognitive deficits and reduced BDNF-TrkB signaling in the prefrontal cortex of their adult offspring...
April 17, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28410370/a-systematic-screen-for-morphological-abnormalities-during-fission-yeast-sexual-reproduction-identifies-a-mechanism-of-actin-aster-formation-for-cell-fusion
#7
Omaya Dudin, Laura Merlini, Felipe O Bendezú, Raphaël Groux, Vincent Vincenzetti, Sophie G Martin
In non-motile fungi, sexual reproduction relies on strong morphogenetic changes in response to pheromone signaling. We report here on a systematic screen for morphological abnormalities of the mating process in fission yeast Schizosaccharomyces pombe. We derived a homothallic (self-fertile) collection of viable deletions, which, upon visual screening, revealed a plethora of phenotypes affecting all stages of the mating process, including cell polarization, cell fusion and sporulation. Cell fusion relies on the formation of the fusion focus, an aster-like F-actin structure that is marked by strong local accumulation of the myosin V Myo52, which concentrates secretion at the fusion site...
April 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28407590/exposure-to-lethal-levels-of-benzo-a-pyrene-or-cadmium-trigger-distinct-protein-expression-patterns-in-earthworms-eisenia-fetida
#8
Lihao Zhang, Xiaochen Duan, Nannan He, Xu Chen, Jinli Shi, Weiming Li, Li Xu, Huixin Li
Different pollutants induce distinct toxic responses in earthworms (Eisenia fetida). Here, we used proteomics techniques to compare the responses of E. fetida to exposure to the 10% lethal concentration (14d-LC10) of benzo[a]pyrene (BaP) or cadmium (Cd) in natural red soil (China). BaP exposure markedly induced the expression of oxidation-reduction proteins, whereas Cd exposure mainly induced the expression of proteins involved in transcription- and translation-related processes. Furthermore, calmodulin-binding proteins were differentially expressed upon exposure to different pollutants...
April 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28402887/the-closed-state-of-the-thin-filament-is-not-occupied-in-fully-activated-skeletal-muscle
#9
Sergey Y Bershitsky, Natalia A Koubassova, Michael A Ferenczi, Galina V Kopylova, Theyencheri Narayanan, Andrey K Tsaturyan
Muscle contraction is powered by actin-myosin interaction controlled by Ca(2+) via the regulatory proteins troponin (Tn) and tropomyosin (Tpm), which are associated with actin filaments. Tpm forms coiled-coil dimers, which assemble into a helical strand that runs along the whole ∼1 μm length of a thin filament. In the absence of Ca(2+), Tn that is tightly bound to Tpm binds actin and holds the Tpm strand in the blocked, or B, state, where Tpm shields actin from the binding of myosin heads. Ca(2+) binding to Tn releases the Tpm from actin so that it moves azimuthally around the filament axis to a closed, or C, state, where actin is partially available for weak binding of myosin heads...
April 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28392437/a-model-of-cardiac-contraction-based-on-novel-measurements-of-tension-development-in-human-cardiomyocytes
#10
Sander Land, So-Jin Park-Holohan, Nicolas P Smith, Cristobal G Dos Remedios, Jonathan C Kentish, Steven A Niederer
Experimental data from human cardiac myocytes at body temperature is crucial for a quantitative understanding of clinically relevant cardiac function and development of whole-organ computational models. However, such experimental data is currently very limited. Specifically, important measurements to characterize changes in tension development in human cardiomyocytes that occur with perturbations in cell length are not available. To address this deficiency, in this study we present an experimental data set collected from skinned human cardiac myocytes, including the passive and viscoelastic properties of isolated myocytes, the steady-state force calcium relationship at different sarcomere lengths, and changes in tension following a rapid increase or decrease in length, and after constant velocity shortening...
April 7, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28379313/early-sensitization-of-myofilaments-to-ca2-prevents-genetically-linked-dilated-cardiomyopathy-in-mice
#11
Marco L Alves, Chad M Warren, Jillian N Simon, Robert D Gaffin, Eric M Montminy, David F Wieczorek, R John Solaro, Beata M Wolska
Background: : Dilated cardiomoypathies (DCM) are a heterogeneous group of inherited and acquired diseases characterized by decreased contractility and enlargement of cardiac chambers and a major cause of morbidity and mortality. Mice with Glu54Lys mutation in α-tropomyosin (Tm54) demonstrate typical DCM phenotype with reduced myofilament Ca 2+ sensitivity. We tested the hypothesis that early sensitization of the myofilaments to Ca 2+ in DCM can prevent the DCM phenotype. Methods and Results: To sensitize Tm54 myofilaments, we used a genetic approach and crossbred Tm54 mice with mice expressing slow skeletal troponin I (ssTnI) that sensitizes myofilaments to Ca 2+ ...
April 3, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28378936/the-tumor-suppressor-tropomyosin-tpm2-1-regulates-sensitivity-to-apoptosis-beyond-anoikis-characterized-by-changes-in-the-levels-of-intrinsic-apoptosis-proteins
#12
Melissa Desouza-Armstrong, Peter W Gunning, Justine R Stehn
The actin cytoskeleton is a polymer system that acts both as a sensor and mediator of apoptosis. Tropomyosins (Tpm) are a family of actin binding proteins that form co-polymers with actin and diversify actin filament function. Previous studies have shown that elevated expression of the tropomyosin isoform Tpm2.1 sensitized cells to apoptosis induced by cell detachment (anoikis) via an unknown mechanism. It is not yet known whether Tpm2.1 or other tropomyosin isoforms regulate sensitivity to apoptosis beyond anoikis...
April 5, 2017: Cytoskeleton
https://www.readbyqxmd.com/read/28375203/the-serum-protein-levels-of-the-tpa-bdnf-pathway-are-implicated-in-depression-and-antidepressant-treatment
#13
H Jiang, S Chen, C Li, N Lu, Y Yue, Y Yin, Y Zhang, X Zhi, D Zhang, Y Yuan
Evidence demonstrates that brain-derived neurotrophic factor (BDNF) has a pivotal role in the pathogenesis of major depressive disorder (MDD). Precursor-BDNF (proBDNF) and mature BDNF (mBDNF) have opposing biological effects in neuroplasticity, and the tissue-type plasminogen activator (tPA)/plasmin system is crucial in the cleavage processing of proBDNF to mBDNF. However, very little is known about the role of the tPA-BDNF pathway in MDD. We examined serum protein concentrations in the tPA-BDNF pathway, including tPA, BDNF, tropomyosin receptor kinase B (TrkB), proBDNF and p75NTR, obtained from 35 drug-free depressed patients before and after 8 weeks of escitalopram (mean 12...
April 4, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28359939/tropomyosin-1-multiple-roles-in-the-developing-heart-and-in-the-formation-of-congenital-heart-defects
#14
Jennifer England, Javier Granados-Riveron, Luis Polo-Parada, Diji Kuriakose, Christopher Moore, J David Brook, Catrin S Rutland, Kerry Setchfield, Christopher Gell, Tushar K Ghosh, Frances Bu'Lock, Christopher Thornborough, Elisabeth Ehler, Siobhan Loughna
Tropomyosin 1 (TPM1) is an essential sarcomeric component, stabilising the thin filament and facilitating actin's interaction with myosin. A number of sarcomeric proteins, such as alpha myosin heavy chain, play crucial roles in cardiac development. Mutations in these genes have been linked to congenital heart defects (CHDs), occurring in approximately 1 in 145 live births. To date, TPM1 has not been associated with isolated CHDs. Analysis of 380 CHD cases revealed three novel mutations in the TPM1 gene; IVS1+2T>C, I130V, S229F and a polyadenylation signal site variant GATAAA/AATAAA...
March 27, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28352236/insights-and-challenges-of-multi-scale-modeling-of-sarcomere-mechanics-in-ctn-and-tm-dcm-mutants-genotype-to-cellular-phenotype
#15
REVIEW
Sukriti Dewan, Kimberly J McCabe, Michael Regnier, Andrew D McCulloch
Dilated Cardiomyopathy (DCM) is a leading cause of sudden cardiac death characterized by impaired pump function and dilatation of cardiac ventricles. In this review we discuss various in silico approaches to elucidating the mechanisms of genetic mutations leading to DCM. The approaches covered in this review focus on bridging the spatial and temporal gaps that exist between molecular and cellular processes. Mutations in sarcomeric regulatory thin filament proteins such as the troponin complex (cTn) and Tropomyosin (Tm) have been associated with DCM...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28351853/pharmaceutical-characterization-of-tropomyosin-receptor-kinase-b-agonistic-antibodies-on-human-ips-cell-derived-neurons
#16
Stefanie Traub, Heiko Stahl, Holger Rosenbrock, Eric Simon, Lore Florin, Lisa Hospach, Stefan Hoerer, Ralf Heilker
Brain-derived neurotrophic factor (BDNF) is a central modulator of neuronal development and synaptic plasticity in the central nervous system (CNS). This renders the BDNF-modulated tropomyosin receptor kinase B (TrkB) a promising drug target to treat synaptic dysfunctions. Using GRowth factor-driven expansion and INhibition of NotCH during maturation, the so-called GRINCH neurons were derived from human induced pluripotent stem (hiPS) cells. These GRINCH neurons were employed as model cells for pharmacological profiling of two TrkB-agonistic antibodies, hereafter referred to as AB2 and AB20...
March 28, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28349532/determining-the-effect-of-malondialdehyde-on-the-ige-binding-capacity-of-shrimp-tropomyosin-upon-in-vitro-digestion
#17
Liangtao Lv, Lin Hong, Zhenxing Li, Ishfaq Ahmed, Guanzhi Chen
BACKGROUND: Stability in simulated gastric fluids is considered an important parameter for the estimation of food allergenicity. Moreover, proteins in food are highly susceptible to lipid oxidation during processing and preservation. In this study, the change in the IgE-binding capacity of malondialdehyde (MDA)-treated shrimp tropomyosin (TM) following in vitro digestion was investigated by SDS-PAGE and Western blot. RESULTS: Shrimp TM treated with different concentrations of MDA was slightly degraded and became increasingly resistant to pepsin digestion over time...
March 28, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28345137/a-comparative-analysis-of-phosphoproteome-in-ovine-muscle-at-early-postmortem-in-relationship-to-tenderness-%C3%A2
#18
Xin Li, Lijuan Chen, Fan He, Meng Li, Qingwu Shen, Dequan Zhang
BACKGROUND: Tenderness is considered to be the most important quality characteristic of meat as it is the main cause of unacceptability of meat. Post-translational modification regulates protein functions that involve in postmortem changes in muscle and meat quality formation. Specifically, phosphorylation was proved to regulate postmortem glycolytic rates and meat tenderization. However, the relationship between protein phosphorylation and meat tenderness remains unclear. This study examined the phosphoproteomes found in ovine muscle with different degrees of tenderness over time (at 0...
March 26, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28344123/effects-of-campylobacter-jejuni-lipopolysaccharide-on-axonal-injury-in-the-spinal-cord-in-rats
#19
Xusheng Li, Haohao Chen, Hongmiao Tao, Ye Hu, Hongqiang Lou
To explore the effects of Campylobacter jejuni lipopolysaccharide (Cj-LPS) on axonal injury in the spinal cord. Wistar rats were divided into the control (NC) group, model group (Cj-LPS), and LPS antibody group (Anti-LPS). Rats in the NC group were injected with a mixture of normal saline and complete Freund's adjuvant (CFA) while those in Cj-LPS group were injected with Cj-LPS, composed of LPS, CFA, and saline. Rats were sacrificed at 4th week and 6th week after injection, and hematoxylin and eosin (HE) staining was performed on the spinal cord sections...
March 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28339033/role-of-tropomyosin-in-silkworm-allergy
#20
Kyoung Yong Jeong, In-Soo Han, June Yong Lee, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park
Silkworm pupae are widely consumed in Asian countries and allergic reactions following consumption have been described. However, false‑positive responses in skin prick allergy tests or non‑specific immunoglobulin E (IgE) responses to total extract of silkworm pupa make diagnosis difficult. Although improved allergy diagnosis is required, molecular characterization of silkworm allergens has not been performed to date, except for Bomb m 1, an arginine kinase. This study aimed to evaluate the allergenicity of tropomyosin, a well‑established invertebrate pan‑allergen, from silkworm pupa...
May 2017: Molecular Medicine Reports
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