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Tropomyosin

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https://www.readbyqxmd.com/read/27903722/adenosine-kinase-deficiency-in-the-brain-results-in-maladaptive-synaptic-plasticity
#1
Ursula S Sandau, Mariana Colino-Oliveira, Abbie Jones, Bounmy Saleumvong, Shayla Q Coffman, Long Liu, Catarina Miranda-Lourenço, Cátia Palminha, Vânia L Batalha, Yiming Xu, Yuqing Huo, Maria J Diógenes, Ana M Sebastião, Detlev Boison
: Adenosine kinase (ADK) deficiency in human patients (OMIM:614300) disrupts the methionine cycle and triggers hypermethioninemia, hepatic encephalopathy, cognitive impairment, and seizures. To identify whether this neurological phenotype is intrinsically based on ADK deficiency in the brain or if it is secondary to liver dysfunction, we generated a mouse model with a brain-wide deletion of ADK by introducing a Nestin-Cre transgene into a line of conditional ADK deficient Adk(fl/fl) mice...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27885498/prognostic-predictive-value-of-gene-mutations-in-japanese-patients-with-hypertrophic-cardiomyopathy
#2
Ayako Chida, Kei Inai, Hiroki Sato, Eriko Shimada, Tsutomu Nishizawa, Mitsuyo Shimada, Michiko Furutani, Yoshiyuki Furutani, Yoichi Kawamura, Masaya Sugimoto, Jun Ishihara, Masako Fujiwara, Takashi Soga, Masatoshi Kawana, Shinya Fuji, Shigeru Tateno, Kenji Kuraishi, Shigetoyo Kogaki, Mitsuhiro Nishimura, Mamoru Ayusawa, Fukiko Ichida, Hirokuni Yamazawa, Rumiko Matsuoka, Shigeaki Nonoyama, Toshio Nakanishi
Although some studies have attempted to find useful prognostic factors in hypertrophic cardiomyopathy (HCM), those results are not fully helpful for use in actual clinical practice. Furthermore, several genetic abnormalities associated with HCM have been identified. However, the genotype-phenotype correlation in HCM remains to be elucidated. Here, we attempted to assess patients with different types of gene mutations causing HCM and investigate the prognosis. A total of 140 patients with HCM underwent a screening test for myofilament gene mutations by direct sequencing of eight sarcomeric genes...
November 24, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27878731/effect-of-cardiomyopathic-mutations-in-tropomyosin-on-calcium-regulation-of-the-actin-myosin-interaction-in-skeletal-muscle
#3
G V Kopylova, D V Shchepkin, D I Borovkov, A M Matyushenko
Tropomyosin plays an important role in the regulation of actin-myosin interaction in striated muscles. Mutations in the tropomyosin gene disrupt actin-myosin interaction and lead to myopathies and cardiomyopathies. Tropomyosin with mutations in the α-chain is expressed in both the myocardium and skeletal muscles. We studied the effect of mutations in the α-chain of tropomyosin related to hypertrophic (D175N and E180G) and dilated cardiomyopathies (E40K and E54K) on calcium regulation of the actin-myosin interaction in skeletal muscles...
November 23, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27878725/effect-of-cardiac-myosin-binding-protein-c-on-tropomyosin-regulation-of-actin-myosin-interaction-using-in-vitro-motility-assay
#4
D V Shchepkin, G V Kopylova, L V Nikitina
We studied the modulating role of cardiac myosin-binding protein C (cMyBP-C) in tropomyosin regulation of the actin-myosin interaction. The effect of cMyBP-C on the velocity of actin-tropomyosin filament sliding over cardiac and slow skeletal myosins was evaluated using in vitro motility assay. The effect of cMyBP-C on the actin-tropomyosin filaments sliding depended on the type of myosin. The regulatory effect of cMyBP-C differs for cardiac and slow skeletal myosin because of the presence of specific essential light chain (LC1sa) in slow skeletal myosin isoform...
November 23, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27875242/involvement-of-bdnf-trkb-and-erk-creb-axes-in-nitroglycerin-induced-rat-migraine-and-effects-of-estrogen-on-these-signals-in-the-migraine
#5
Jiu-Qing Guo, Hui-Hui Deng, Xiao Bo, Xiao-Su Yang
Migraine is a highly prevalent headache disorder especially in women. Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin receptor kinases (TrkB), as well as extracellular signal-regulated kinase (ERK) and its downstream target c-AMP-responsive element binding protein (CREB) are strongly associated with the transmission of nociceptive information. However, the involvement of these substances in migraine has rarely been examined. In the present study, intraperitoneal injection of nitroglycerin (NTC) successfully induced rat migraine attack, as evidenced by the behavioral testing...
November 14, 2016: Biology Open
https://www.readbyqxmd.com/read/27866892/tropomyosin-and-profilin-cooperate-to-promote-formin-mediated-actin-nucleation-and-drive-yeast-actin-cable-assembly
#6
Salvatore L Alioto, Mikael V Garabedian, Danielle R Bellavance, Bruce L Goode
Tropomyosins comprise a large family of actin-binding proteins with critical roles in diverse actin-based processes [1], but our understanding of how they mechanistically contribute to actin filament dynamics has been limited. We addressed this question in S. cerevisiae, where tropomyosins (Tpm1 and Tpm2), profilin (Pfy1), and formins (Bni1 and Bnr1) are required for the assembly of an array of actin cables that facilitate polarized vesicle delivery and daughter cell growth. Formins drive cable formation by promoting actin nucleation and by accelerating actin filament elongation together with profilin [2]...
November 15, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27866198/proteomic-analysis-and-identification-of-paracrine-factors-in-mesenchymal-stem-cell-conditioned-media-under-hypoxia
#7
Suk-Won Song, Kyung-Eun Kim, Jung-Won Choi, Chang Youn Lee, Jiyun Lee, Hyang-Hee Seo, Kyu Hee Lim, Soyeon Lim, Seahyong Lee, Sang Woo Kim, Ki-Chul Hwang
BACKGROUND/AIMS: We previously showed that a hypoxic environment modulates the antiarrhythmic potential of mesenchymal stem cells. METHODS: To investigate the mechanism by which secreted proteins contribute to the pathogenesis of antiarrhythmic potential in mesenchymal stem cells, we used two-dimensional electrophoresis combined with MALDI-TOF-MS to perform a proteomic analysis to compare the paracrine media produced by normoxic and hypoxic cells. RESULTS: The proteomic analysis revealed that 66 protein spots out of a total of 231 matched spots indicated differential expression between the normoxic and hypoxic conditioned media of mesenchymal stem cells...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27856252/the-interchain-disulfide-cross-linking-of-tropomyosin-alters-its-regulatory-properties-and-interaction-with-actin-filament
#8
Alexander M Matyushenko, Natalia V Artemova, Daniil V Shchepkin, Galina V Kopylova, Salavat R Nabiev, Larisa V Nikitina, Dmitrii I Levitsky, Sergey Y Bershitsky
Tropomyosin (Tpm) is an α-helical coiled-coil actin-binding protein that plays a key role in the Ca(2+)-regulated contraction of striated muscles. Two chains of Tpm can be cross-linked by formation of a disulfide bond between Cys-190 residues. Normally, the SH-groups of these residues in cardiac muscle are in reduced state but in heart pathologies the interchain cross-linking of Tpm was shown to occur. Previous studies have shown that this cross-linking increases the thermal stability of the C-terminal part of the Tpm molecule...
November 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27856237/synthesis-anticancer-and-docking-studies-of-salicyl-hydrazone-analogues-a-novel-series-of-small-potent-tropomyosin-receptor-kinase-a-inhibitors
#9
Mohammad Sayed Alam, Sang-Un Choi, Dong-Ung Lee
A series of novel salicyl-hydrazone analogues were synthesized and evaluated for their in vitro cytotoxic activities in five human cancer cell lines, namely, lung cancer (A549), ovarian cancer (SK-OV-3), skin cancer (SK-MEL-2), colon cancer (HCT15) and pancreatic cancer (MIA-PaCa-2) cells, and for their in vitro tropomyosin receptor kinase A (TrkA) inhibitory activities. Each of the compounds showed significant cytotoxicity against all cancer cells. Compound 3i was found to be most potent against all cancer cell lines with IC50 values of 2...
November 3, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27853755/differential-stress-response-mechanisms-in-right-and-left-ventricles
#10
Makhosazane Zungu-Edmondson, Yuichiro J Suzuki
Right ventricular (RV) failure is the major cause of death among patients with pulmonary hypertension. However, differences between the RV and left ventricle (LV) of the adult heart have not been defined, despite myocytes from these two ventricles originate from different progenitor cells. The lack of such knowledge interferes with developing therapeutic strategies to protect the RV. The goal of this study was to identify possible differences between stress responses in the RV and LV free walls of adult rats...
2016: Journal of Rare Diseases Research & Treatment
https://www.readbyqxmd.com/read/27853305/tropomyosin-receptor-kinase-c-targeted-delivery-of-a-peptidomimetic-ligand-photosensitizer-conjugate-induces-antitumor-immune-responses-following-photodynamic-therapy
#11
Chin Siang Kue, Anyanee Kamkaew, Siew Hui Voon, Lik Voon Kiew, Lip Yong Chung, Kevin Burgess, Hong Boon Lee
Tropomyosin receptor kinase C (TrkC) targeted ligand-photosensitizer construct, IYIY-diiodo-boron-dipyrromethene (IYIY-I2-BODIPY) and its scrambled counterpart YIYI-I2-BODIPY have been prepared. IYIY-I2-BODIPY binds TrkC similar to neurotrophin-3 (NT-3), and NT-3 has been reported to modulate immune responses. Moreover, it could be shown that photodynamic therapy (PDT) elevates antitumor immune responses. This prompted us to investigate the immunological impacts mediated by IYIY-I2-BODIPY in pre- and post-PDT conditions...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27852831/a-new-tropomyosin-for-oskar-mrna
#12
(no author information available yet)
No abstract text is available yet for this article.
November 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27846214/proteomic-profiling-for-identification-of-novel-biomarkers-differentially-expressed-in-human-ovaries-from-polycystic-ovary-syndrome-patients
#13
Li Li, Jiangyu Zhang, Qingshan Deng, Jieming Li, Zhengfen Li, Yao Xiao, Shuiwang Hu, Tiantian Li, Qiuxiao Tan, Xiaofang Li, Bingshu Luo, Hui Mo
OBJECTIVES: To identify differential protein expression pattern associated with polycystic ovary syndrome (PCOS). METHODS: Twenty women were recruited for the study, ten with PCOS as a test group and ten without PCOS as a control group. Differential in-gel electrophoresis (DIGE) analysis and mass spectroscopy were employed to identify proteins that were differentially expressed between the PCOS and normal ovaries. The differentially expressed proteins were further validated by western blot (WB) and immunohistochemistry (IHC)...
2016: PloS One
https://www.readbyqxmd.com/read/27843590/ntrk-gene-fusions-as-novel-targets-of-cancer-therapy-across-multiple-tumour-types
#14
REVIEW
Alessio Amatu, Andrea Sartore-Bianchi, Salvatore Siena
The tropomyosin receptor kinase (Trk) receptor family comprises 3 transmembrane proteins referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the NTRK1, NTRK2 and NTRK3 genes, respectively. These receptor tyrosine kinases are expressed in human neuronal tissue and play an essential role in the physiology of development and function of the nervous system through activation by neurotrophins. Gene fusions involving NTRK genes lead to transcription of chimeric Trk proteins with constitutively activated or overexpressed kinase function conferring oncogenic potential...
2016: ESMO Open
https://www.readbyqxmd.com/read/27834145/pharmacogenetics-and-pharmacotherapy-of-military-personnel-suffering-from-posttraumatic-stress-disorder
#15
Janine Naß, Thomas Efferth
BACKGROUND: Posttraumatic stress disorder (PTSD) is a severe problem among soldiers with combat experience and still difficult to treat. The pathogenesis is still not fully understood at the psychological level. Therefore, genetic research became a focus of interest. The identification of single nucleotide polymorphisms (SNPs) may help to predict, which persons are at high risk to develop PTSD as a starting point to develop novel targeted drugs for treatment. METHODS: We conducted a systematic review on SNPs in genes related to PTSD pathology and development of targeted pharmacological treatment options based on PubMed database searches...
November 11, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27833955/neuro-neoplastic-interrelationships-in-colorectal-level-immunohistochemical-aspect-in-three-cases-and-review-of-the-literature
#16
Cristina Florescu, Octavian Istrătoaie, Georgică Costinel Târtea, Daniel Pirici, Costin Teodor Streba, Bogdan Cătălin, Ileana Puiu, Elena Anca Târtea, Daniel Cosmin Caragea, Mirela Corina Ghiluşi, Maria Victoria Comănescu, Ion Rogoveanu, Cristin Constantin Vere
Colorectal cancer represents a severe public health issue. Recent studies have shown the essential role played by nerves and their neurotransmitters in tumor initiation and progression. The aim of this study is to asses the expression of beta 2-adrenergic receptors (β2A) for adrenaline and noradrenaline, and the expression of M3 muscarinic receptors (M3R) for acetylcholine (neurotransmitters produced and released by sympathetic and parasympathetic afferents of the digestive tract and also by the enteric nervous system) in different tumor gradings of colorectal adenocarcinoma, and also the tropomyosin receptor kinase A (TrkA) for the nerve growth factor produced by the cells of colorectal adenocarcinoma...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27833562/predicting-effects-of-tropomyosin-mutations-on-cardiac-muscle-contraction-through-myofilament-modeling
#17
Lorenzo R Sewanan, Jeffrey R Moore, William Lehman, Stuart G Campbell
Point mutations to the human gene TPM1 have been implicated in the development of both hypertrophic and dilated cardiomyopathies. Such observations have led to studies investigating the link between single residue changes and the biophysical behavior of the tropomyosin molecule. However, the degree to which these molecular perturbations explain the performance of intact sarcomeres containing mutant tropomyosin remains uncertain. Here, we present a modeling approach that integrates various aspects of tropomyosin's molecular properties into a cohesive paradigm representing their impact on muscle function...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27826102/the-trka-receptor-mediates-experimental-thermal-hyperalgesia-produced-by-nerve-growth-factor-modulation-by-the-p75-neurotrophin-receptor
#18
Alla Khodorova, Grant D Nicol, Gary Strichartz
The p75 neurotrophin receptor (p75(NTR)) and its activation of the sphingomyelin signaling cascade are essential for mechanical hypersensitivity resulting from locally injected nerve growth factor (NGF). Here the roles of the same effectors, and of the tropomyosin receptor kinase A (TrkA) receptor, are evaluated for thermal hyperalgesia from NGF. Sensitivity of rat hind paw plantar skin to thermal stimulation after local sub-cutaneous injection of NGF (500ng) was measured by the latency for paw withdrawal (PWL) from a radiant heat source...
November 5, 2016: Neuroscience
https://www.readbyqxmd.com/read/27824119/intake-of-7-8-dihydroxyflavone-during-juvenile-and-adolescent-stages-prevents-onset-of-psychosis-in-adult-offspring-after-maternal-immune-activation
#19
Mei Han, Ji-Chun Zhang, Wei Yao, Chun Yang, Tamaki Ishima, Qian Ren, Min Ma, Chao Dong, Xu-Feng Huang, Kenji Hashimoto
Prenatal infection and subsequent abnormal neurodevelopment of offspring is involved in the etiology of schizophrenia. Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the neurodevelopment. Pregnant mice exposed to polyriboinosinic-polyribocytidylic acid [poly(I:C)] causes schizophrenia-like behavioral abnormalities in their offspring at adulthood. Here we found that the juvenile offspring of poly(I:C)-treated mice showed cognitive deficits, as well as reduced BDNF-TrkB signaling in the prefrontal cortex (PFC)...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822248/proteomic-analysis-of-muscle-tissue-from-rainbow-trout-oncorhynchus-mykiss-fed-dietary-%C3%AE-glucan
#20
Gh Ghaedi, S Keyvanshokooh, H Mohammadi Azarm, M Akhlaghi
The aim of this study was to examine the changes in muscle proteome of the rainbow trout fed dietary β-glucan. The experimental diets contained 0 (control), 0.1% and 0.2% β-1,3/1,6 yeast glucan. First, feeding larvae were fed to apparent satiation nine times per day with their respective diets over two months. The percentage of body weight gain and feed efficiency of fish fed 0.2% diet was significantly higher than those of fish fed the control and 0.1% diets. Fish fed the control and 0.2% diets were subjected to proteomic analysis...
2016: Iranian journal of veterinary research
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