Lin-Yan Huang, Yi-de Zhang, Yi-Ning Liu, Zhi-Yan Liang, Jie Chen, Bin Wang, Qi-Long Yin, Pei-Pei Wang, Wan Wang, Su-Hua Qi
Neuronal death resulting from ischemic stroke is the primary cause of adult mortality and disability, and effective neuroprotective agents for poststroke intervention are still lacking. Remote ischemic postconditioning (RIPostC) has demonstrated significant protective effects against ischemia in various organs; however, the specific mechanisms are not fully understood. This study investigated the potential neuroprotective mechanisms of RIPostC in the context of ischemic stroke. Using a rat model of middle cerebral artery occlusion, we found that RIPostC mitigated neurological damage, improved movement in the open-field test, and protected against neuronal apoptosis...
April 18, 2024: ACS Chemical Neuroscience